+

WO1996017865A3 - Gene und genprodukte zur diagnostik von degenerativer nervenschädigung - Google Patents

Gene und genprodukte zur diagnostik von degenerativer nervenschädigung Download PDF

Info

Publication number
WO1996017865A3
WO1996017865A3 PCT/EP1995/004777 EP9504777W WO9617865A3 WO 1996017865 A3 WO1996017865 A3 WO 1996017865A3 EP 9504777 W EP9504777 W EP 9504777W WO 9617865 A3 WO9617865 A3 WO 9617865A3
Authority
WO
WIPO (PCT)
Prior art keywords
genes
gene products
diagnosis
nerve damage
degenerative nerve
Prior art date
Application number
PCT/EP1995/004777
Other languages
English (en)
French (fr)
Other versions
WO1996017865A2 (de
Inventor
Hans-Werner Mueller
Clemens Gillen
Marc Gleichmann
Original Assignee
Boehringer Mannheim Gmbh
Mueller Hans Werner
Clemens Gillen
Marc Gleichmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19502525A external-priority patent/DE19502525A1/de
Application filed by Boehringer Mannheim Gmbh, Mueller Hans Werner, Clemens Gillen, Marc Gleichmann filed Critical Boehringer Mannheim Gmbh
Priority to AU43023/96A priority Critical patent/AU693982B2/en
Priority to EP95941669A priority patent/EP0796275A2/de
Priority to JP8517317A priority patent/JPH10511544A/ja
Publication of WO1996017865A2 publication Critical patent/WO1996017865A2/de
Publication of WO1996017865A3 publication Critical patent/WO1996017865A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Die Erfindung betrifft neue Gene und Genprodukte, die in degenerierenden und/oder regenerierenden peripheren Nerven exprimiert werden, sowie deren Anwendung zur Diagnose und/oder Therapie. Die in SEQ ID NO:1 bis 30 genannten Nukleinsäuren hybridisieren mit den erfindungsgemäßen Nukleinsäuren.
PCT/EP1995/004777 1994-12-05 1995-12-05 Gene und genprodukte zur diagnostik von degenerativer nervenschädigung WO1996017865A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU43023/96A AU693982B2 (en) 1994-12-05 1995-12-05 Genes and gene products for use in the diagnosis of degenerative nerve damage
EP95941669A EP0796275A2 (de) 1994-12-05 1995-12-05 Gene und genprodukte zur diagnostik degenerativer nervenschädigungen
JP8517317A JPH10511544A (ja) 1994-12-05 1995-12-05 変性神経損傷の診断及び再生のための新規遺伝子及び遺伝子産物

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEP4443159.7 1994-12-05
DE4443159 1994-12-05
DE19502525.3 1995-01-27
DE19502525A DE19502525A1 (de) 1994-12-05 1995-01-27 Neue Gene und Genprodukte zur Diagnostik und Regeneration degenerativer Nervenschädigungen

Publications (2)

Publication Number Publication Date
WO1996017865A2 WO1996017865A2 (de) 1996-06-13
WO1996017865A3 true WO1996017865A3 (de) 1996-09-19

Family

ID=25942564

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/004777 WO1996017865A2 (de) 1994-12-05 1995-12-05 Gene und genprodukte zur diagnostik von degenerativer nervenschädigung

Country Status (5)

Country Link
EP (1) EP0796275A2 (de)
JP (1) JPH10511544A (de)
AU (1) AU693982B2 (de)
CA (1) CA2206994A1 (de)
WO (1) WO1996017865A2 (de)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003569A1 (en) * 1989-08-30 1991-03-21 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Neurotrophin-3, a novel neurotrophic factor related to nerve growth factor and brain derived neurotrophic factor
WO1992020797A1 (en) * 1991-05-20 1992-11-26 Case Western Reserve University Neurotrophic factor, preparation and uses thereof
WO1994021670A1 (en) * 1993-03-15 1994-09-29 The Scripps Research Institute Human serotonin receptors, dna encoding the receptors, and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003569A1 (en) * 1989-08-30 1991-03-21 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Neurotrophin-3, a novel neurotrophic factor related to nerve growth factor and brain derived neurotrophic factor
WO1992020797A1 (en) * 1991-05-20 1992-11-26 Case Western Reserve University Neurotrophic factor, preparation and uses thereof
WO1994021670A1 (en) * 1993-03-15 1994-09-29 The Scripps Research Institute Human serotonin receptors, dna encoding the receptors, and uses thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
A.E.FEUCHTER ET AL.: "Strategy for detecting cellular transcripts promoted by human endogenous long terminal repeats : identific<tion of a novel gene (cdc4l) with homology to yeast CDC4", GENOMICS, vol. 13, pages 1237 - 46, XP000568626 *
DE LEON M ET AL: "IDENTIFICATION OF TRANSCRIPTIONALLY REGULATED GENES AFTER SCIATIC NERVE INJURY", JOURNAL OF NEUROSCIENCE RESEARCH, 29 (4). 1991. 437-448. *
FISCHER I. ET AL.: "Moelcular cloning of plasmolipin", THE JOURNAL OF BIOCHEMICAL CHEMISTRY, vol. 269, no. 40, pages 24912 - 24919 *
GILLEN C ET AL: "Differentially expressed genes after peripheral nerve injury", JOURNAL OF NEUROSCIENCE RESEARCH, 42 (2). 1995. 159-171., XP000568934 *
K.HAYASAKA ET AL.: "Mutation of the myelin Po gene in Charcot-Marie-Tooth neuropathy type 1B", HUMAN MOLECULAR GENETICS, vol. 2, no. 9, pages 1369 - 1372, XP000566482 *
N.H.LEE ET AL.: "Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growt factor treatment", PNAS, vol. 92, pages 8303 - 8307 *
RAUTENSRAUSS B. ET AL.: "Identification of a de novo insertional mutation in P0 in a patient with Dejerine-Sottas syndrome (DSS) phenotype", HUMAN MOLECULAR GENETICS, vol. 3, no. 9, pages 1701 - 1702, XP000266483 *

Also Published As

Publication number Publication date
AU4302396A (en) 1996-06-26
EP0796275A2 (de) 1997-09-24
AU693982B2 (en) 1998-07-09
JPH10511544A (ja) 1998-11-10
CA2206994A1 (en) 1996-06-13
WO1996017865A2 (de) 1996-06-13

Similar Documents

Publication Publication Date Title
CA2177357A1 (en) PNA-DNA-PNA Chimeric Macromolecules
CA2294516A1 (en) Ikk-.beta. proteins, nucleic acids and methods
CA2205382A1 (en) Enzymatic dna molecules
CA2274581A1 (en) Oligonucleotide compositions and methods for the modulation of the expression of b7 protein
CA2200371A1 (en) Human npik gene
WO1998020165A3 (en) Biallelic markers
CA2295999A1 (en) Nik proteins, nucleic acids and methods
PL328563A1 (en) Oligonucleotides of modified sugar residues
CA2194761A1 (en) Immunomodulatory oligonucleotides
DE69829287D1 (de) Verbesserung der verabreichung der nukleinsäure in zellen der plurizellulären eukaryotischen organismen und kombination zur durchführung des verfahrens
WO1999053061A3 (en) Tumor associated nucleic acids and uses therefor
CA2221448A1 (en) Antisense oligonucleotide modulation of raf gene expression
WO2001047944A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO1998018932A3 (en) Novel pesticidal toxins and nucleotide sequences which encode these toxins
AU2299999A (en) Dnas or genes participating in parkinson&#39;s disease
WO2000029623A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
CA2304926A1 (en) Robo: a family of polypeptides and nucleic acids involved in nerve guidance
WO1998054313A3 (en) Dna methyltransferase genomic sequences and antisense oligonucleotides
CA2294476A1 (en) Semaphorin receptors
AU5137498A (en) Iga nephropathy-associated gene
CA2340934A1 (en) Novel collectin
WO1997024974A3 (en) Compositions and methods for diagnosis of mutation in the von hippel-lindau tumor suppressor gene
CA2146320A1 (en) Antisense oligonucleotide inhibition of the ras gene
WO2000004156A3 (en) SEROTYPE-SPECIFIC PROBES FOR $i(LISTERIA MONOCYTOGENES)
WO1996017865A3 (de) Gene und genprodukte zur diagnostik von degenerativer nervenschädigung

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TT UA UG US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TT UA UG US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 1995941669

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2206994

Country of ref document: CA

Ref country code: CA

Ref document number: 2206994

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref country code: US

Ref document number: 1997 849134

Date of ref document: 19970728

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 1995941669

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1995941669

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载