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WO1995026183A1 - Composition cosmetique et pharmaceutique a base d'extrait de germes de ble - Google Patents

Composition cosmetique et pharmaceutique a base d'extrait de germes de ble Download PDF

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Publication number
WO1995026183A1
WO1995026183A1 PCT/FI1995/000161 FI9500161W WO9526183A1 WO 1995026183 A1 WO1995026183 A1 WO 1995026183A1 FI 9500161 W FI9500161 W FI 9500161W WO 9526183 A1 WO9526183 A1 WO 9526183A1
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WO
WIPO (PCT)
Prior art keywords
ointment
wheat shoot
shoot extract
extract
preparation
Prior art date
Application number
PCT/FI1995/000161
Other languages
English (en)
Inventor
Heikki Juhani Vuorela
Raimo Vilho Kari Hiltunen
Original Assignee
Helsinki University Licensing Ltd Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helsinki University Licensing Ltd Oy filed Critical Helsinki University Licensing Ltd Oy
Priority to AU20747/95A priority Critical patent/AU2074795A/en
Publication of WO1995026183A1 publication Critical patent/WO1995026183A1/fr
Priority to FI955718A priority patent/FI955718A0/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations

Definitions

  • the present invention generally relates to compositions for cosmetic and pharmaceutical use comprising wheat shoot extract and/or thyme oil and to methods and materials for the preparation, stabilization, and use thereof.
  • the present invention relates to compositions comprising wheat shoot extract and/or thyme oil. Such compositions are useful for cosmetic and pharmaceutical purposes and may be formulated inexpensively.
  • the present invention also provides methods for manufacturing and using the above-mentioned compositions. Also provided are methods of stabilizing such compositions.
  • Wheat shoot is very versatile, having a high percentage of raw protein. Amino acid analyses have shown that wheat shoot contains particularly large amounts of aspartic acid, lysine, threonine, valine, leucine, isoleucine, methionine, phenylalanine, tryptophan, arginine, proline, serine, tyrosine, and cysteine.
  • the chlorophyll content of wheat shoot is also high and wheat shoot contains numerous vitamins, minerals, and enzymes. Specifically, it has a very high concentration of vitamin A, vitamin K, and vitamin E.
  • Wheat shoot also contains significant amounts of vitamin C, choline, thiamine, riboflavin, pyridoxine, vitamin B12, niacin, pantothenic acid, biotin, and folic acid. Wheat shoot also contains particularly large amounts of calcium, phosphorus, and potassium; whereas the sodium content is small. Finally, wheat shoot contains a considerable amount of copper, zinc, and selenium, all of which are proposed to be excellent antioxidants. Wheat shoot extract is usually prepared by compressing fresh wheat shoot in, for example, a juice press. The extract must be used immediately after pressing because it spoils very quickly. Mold colonies may form and oxidation may occur, resulting in a loss of potency. Mold colonies are an indication of the extent of spoilage. Wheat shoot extract also may have an unpleasant odor. Because of its rapid deterioration, it has been difficult to develop satisfactory commercial products containing wheat shoot. An attempt has been made to sell wheat shoot extract in the form of ice cubes, but without significant success.
  • British Patent Application GB 1 358 052 which reports a method for preparing an edible powder from unripened grain, such as barley or wheat.
  • a solution to the general problem of lack of stability in grains consists of adjusting the pH of the grain extract to pH 6 - 9, and then jet drying or lyophilizing the extract.
  • the pH may be adjusted by using an alkali metal carbonate or bicarbonate, ammoniumhydroxide, calcium hydroxide, calcium carbonate, or calcium glutamate.
  • GB 1 358 052 reports heating the extract to 90 - 150°C.
  • chemical preservatives such as benzoic acid, methylparahydroxybenzoate or sodium benzoate may be added to stabilize the product. Heating and using chemical preservatives are not generally recommended for food and pharmaceutical products, however.
  • EP Application 279 984 describes pharmaceutical and cosmetic preparations which contain an extract obtained from grasses and especially grain plants combined with a pharmaceutically-acceptable carrier or filler.
  • a suggested carrier or filler is an antimicrobic substance in aqueous solution, possibly with the addition of ascorbic acid or 3-carotene.
  • the extract be sterilized before mixing with the carrier.
  • Patent application FR 1 039 340 describes the extraction of wheat embryos by alcohol and use of the extract obtained in hygienic products. In that procedure, alcohol functions as both a dissolvent and a preservative. No increase in stability is reported, however.
  • Thyme a common plant, of which there are many different varieties and species.
  • the most common species is Thymus v lgaris L. which contains approximately 0.8 - 2.6 g of evaporating oils, the quality and amount of which may vary considerably.
  • Thyme contains phenols, terpene derivatives such as para-cymene and 7- terpinene, and alcohols such as linalol, ⁇ -terpineol and 4-tujanol.
  • the main phenol component is usually thymol, while karvachrolin appears in smaller amounts.
  • thyme also contains tannin, flavonoids, coffee acid, ursolic acid and oleanolic acid.
  • Thyme has been used in cosmetic substances and in pharmaceutical preparations. It has been used in both its fresh and dried forms as an anthelmintic, to treat spasms and flatulence, as a sedative, a sudorific, and as a cough medicine (mainly as a tincture or extract). Thyme has also been used in the treatment of gastritis and diarrhea and as an appetite stimulant. In addition, thyme has been used externally in health baths to relief symptoms of rheumatism and skin problems.
  • compositions according to the present invention display improved storage stability and improved clinical and cosmetic effectiveness with respect to the prior art.
  • Thyme oil in addition to stabilizing the composition, conceals the odor of wheat shoot.
  • Thyme also increases the clinical effectiveness of composition according to the present invention and is effective even in the absence of wheat shoot extract.
  • Compositions according to the invention may be formulated as various cosmetic and pharmaceutical preparations by using known carriers, as well as by using auxiliary and filler substances. On the basis of the desired use of the end-product, the skilled artisan is able to choose components that are suitable in each case.
  • a composition for example, may be a waterless or aqueous cream, lotion, cleansing milk, facial fluid, or a product suitable for treating hair, such as balsam.
  • other components may also be included in compositions according to the invention, such as other active agents, vitamins, minerals, fat components, aromatic substances and the like depending on the use to which the composition is put.
  • a composition according to the present invention comp' --es an effective amount of wheat shoot extract or an effective amount of thy ⁇ .e oil.
  • the composition comprises an effective amount of wheat shoot extract and thyme oil.
  • An effective amount of wheat shoot extract or thyme oil according to the present invention is an amount necessary to achieve a desired therapeutic effect.
  • compositions according to the invention are effective as cosmetics and therapeutics in a variety of applications, some of which are provided herein for exemplification the skilled artisan, depending upon the specific application to which the invention is put, is able to determine an effective amount of wheat shoot extract, thyme oil, or other components without undue experimentation in light of the guidance provided herein.
  • compositions according to the invention comprise wheat shoot extract, thyme oil, and vitamin supplements, preferably vitamins A and/or E.
  • Preferred compositions according to the invention may also comprise a mineral component and may preferably comprise a chelated metal, most preferably zinc.
  • a preferred composition comprises from about 1 g to about 2 g of vitamin A palmitate, from about 20 g to about 60 g zinc sulphate, from about 5 g to about 15 g of 7-tocopherolacetate, from about 10 g to about 25 g freeze-dried wheat shoot extract, from about 5 g to about 12 g of thyme oil, and about 1000 g ointment base.
  • compositions and methods for stabilizing wheat shoot extract including stabilization of biological activity and control of the formation of mold colonies within the extract or composition comprising it.
  • Such compositions comprise members of the group consisting of phenols, terpenes, and alcohols. More particularly, such compositions are selected from the group consisting of para-cymene, ⁇ -terpinene, linalol, ⁇ -terpinol, 4-tujanol, and thymol. Most preferably, such compositions comprise thyme oil. While thyme oil or a related compound may be used as a preservative, it is also effective alone to relieve the various skin disorders described below.
  • the present invention also provides methods for treating skin disorders comprising use of compositions according to the invention.
  • skin disorders include, but are not limited to, eczema, psoriasis, hives, rashes, allergic discoloration, itching, dryness, acne, and others. Additional aspects of the invention are apparent to the skilled artisan upon consideration of the following detailed description thereof.
  • compositions according to the present invention are useful in both pharmaceutical and cosmetic applications.
  • Compositions according to the invention revive and rejuvenate tissue and improve the regeneration of skin and the elimination of dead tissue.
  • such compositions are bactericidal due to the presence of thyme.
  • Claimed compositions additionally have an astringent and antiseptic property and are useful in alleviating various rashes and in healing small wounds.
  • compositions according to the invention nourish and revive skin tissue and are useful as cosmetic skin-care products, to soothe sunburned skin and cure sunburns, and as a pharmaceutical substance in the treatment of minor wounds, injuries and rashes. Composition according to the invention are also useful in the treatment of scalp diseases.
  • Wheat shoot extract for use in compositions and methods according to the invention may be manufactured by growing wheat in a standard manner. Wheat shoots are harvested when they are 10 - 18 cm in length and an extract is made by pressing the shoots in a juicer or similar device. Due to the fact that the extract may become spoiled very quickly, it is advisable to keep it cold. Wheat shoot extract may be concentrated or freeze-dried. Due to the fact that the extract spoils rapidly, lyophilization is often beneficial.
  • compositions according to the invention are mixed with a carrier or filler and other possible components.
  • a carrier or filler may be any suitable for hair treatment, such as a balsam.
  • compositions according to the invention may contain common carrier substances, or other active substances, such as vitamins, minerals, fat components, and aromatic substances.
  • the carrier or cream base used may be an ordinary commercial or basic ointment.
  • An ointment base may be important in releasing the claimed compositions for absorption through the skin into the blood system.
  • the skilled artisan may choose an ointment base for a desired purpose by taking into account such factors as whether one wishes to create a systemic or local effect or if the timing of release is critical and whether the ointment should have an occlusive (i.e. , moisturizing) effect.
  • the precise nature of the compositions of the invention may be determined by the skilled artisan on the basis of the desired therapeutic effect.
  • active substances are released more quickly from aqueous preparations (emulsion ointments), than from ointments which contain only lipid.
  • Fatty ointment bases may improve the absorption of an active ingredient through the skin.
  • Solubility Another factor to be taken into account in the formulation of compositions of the invention, is the solubility of the active ingredient or ingredients into the ointment base. Solubility largely determines the type of ointment to be formulated; i.e. , an emulsion ointment (water/oil or oil/water), a solution ointment, or a suspension ointment. Most medical substances have a poor lipid solubility. Accordingly, a suspension ointment may be more beneficial than a solution ointment in those cases due to its superior rate of release.
  • compositions may be used as ointment bases containing wheat shoot extract and thyme oil.
  • the ointment type may be a 'pure' suspension ointment or may contain both water and lipid phases, and possibly also various auxiliary substances, such as preservatives and emulsifying agents.
  • a lotion may be prepared by using wheat shoot extract as the water phase in combination with a suitable carrier.
  • composition according to the invention was manufactured comprising:
  • Vitamin A-palmitate 0.825 g Zinc sulphate 22.0 g ⁇ -tocopherol acetate 5.0 g
  • Thyme oil 4.0 g Ointment base 500.0 g
  • Vitamin A-palmitate is a powder which must be kept cool and which, though it mixes with water, does not dissolve into it.
  • Zinc sulphate is added in the form of a powder, which dissolves into water in the proportion of 1:0.6.
  • ⁇ -tocopherol acetate is an oil-like liquid, which does not dissolve into water.
  • Sodium selenite is in the form of a powder with large crystals and is very water-soluble. Sodium selenite is added to a few of the compositions. However, compositions without sodium selenite may also be made. In performing tests on stability, no difference was found between compositions containing sodium selenite and those without.
  • the resulting wheat shoot extract was a lyophilized, flaky substance, which did not dissolve well in water.
  • Thyme oil is an oily liquid, which does not dissolve into water. Water used in claimed compositions is preferably distilled and at room temperature.
  • compositions according to the present invention A number of commercially-available ointment bases may be used as an ointment base component in compositions according to the present invention. Representative commercial bases, their water content and manufacturer are provide below. Compositions were prepared as described above by simple mixing using any suitable mixing device, including hand mixing, each with only one of the bases provided below. Thus, preparation numbers 1 - 6 refer to a composition as described above using the indicated base.
  • a representative composition according to the present invention was manufactured as follows: Zinc sulphate and, optionally, sodium selenite were dissolved in a separate vessel into 20 g of distilled water at room temperature.
  • Wheat shoot extract particles were pulverized, if necessary, to obtain a maximum particle size of 300 ⁇ m.
  • the sifted ingredients were manually mixed into a homogeneous ointment paste using 50 g of the ointment base, after which about 150 g of the ointment base were added and mixed for a few minutes in a Kenwood mixer at maximum speed. Thyme oil and ⁇ -tocopherol were added to the resulting composition, which was again mixed at high speed for a few minutes. The zinc sulphate solution described above was then added to the composition, and likewise mixed at high speed for a few minutes. The remaining quantity (500 g) of the ointment base was then added and mixed at high speed for a few minutes.
  • composition of the wheat shoot extract ointment was the same as in Example 1.
  • the formulated ointment bases used in the preparations were as follows:
  • the sifted ingredients were manually mixed into a homogeneous ointment paste using about 50 g of the ointment base, after which about 150 g of ointment base was added and mixed a few minutes in a Kenwood mixer at maximum speed.
  • Thyme oil and ⁇ -tocopherol were added to the resulting compositions, which was again mixed at high speed for a few minutes.
  • the remaining quantity (500 g) of the ointment base was then added and mixed at high speed for a few minutes.
  • Example 1 The basic ointment was prepared from individual raw materials, with the solid substances in the composition being added during the preparation of the ointment base. A 3% solution of wheat shoot extract was used instead of dry powder extract, with a 3 % extract solution being used as the water phase of the emulsion ointment base to be prepared.
  • a Lipid phase preparation (80 g white vaseline, 80 g stearic acid, 80 g cetaceum, 420 g peanut oil and 0.2 g propylparahydroxbentsoate) was weighed into one vessel and wheat shoot extract and the other substances to be added to the aqueous phase (20 g glycerol, 0.3 g triethanolamine, possibly sodium selenite and zinc sulphate) were weighed into a separate vessel. Amounts of ingredients were calculated for a preparation of 1000 g, which also contains water. The solid substances were melted into the lipid phase on a water bath, the temperature of which was adjusted to be the same as that of the lipid phase.
  • the lipid phase was transferred to the ointment mixer vessel, to which vitamin A- palmitate and ⁇ -tocopherol were added.
  • the mixer was turned on and the water phase added, after which they were mixed for about 5 minutes. Finally, thyme oil was added and mixed for about 5 minutes, after which Preparation 9 was obtained.
  • the cooling speed of the phases may also be controlled to prevent separation. This can be done by either using a heat jacket around the mixing vessel or by heat infusion, whereby the phase in the mixing vessel remains constant at the desired temperature.
  • the composition of the wheat shoot extract ointment was the same as in Example 1.
  • the basic ointment was prepared from individual raw materials, with the solid substances in the composition being added during the preparation of the ointment base.
  • the dried wheat shoot extract powder was added by suspension.
  • a lipid phase 120 g white vaseline, 120 g stearic acid, 80 g cetaceum, 420 g peanut oil and 0.2 g propylparahydroxbentsoate
  • Distilled water and other substances to be added to the aqueous phase 240 g glycerol, 0.3 g triethanolamine, possibly sodium selenite and zinc sulphate
  • the solid substances were melted into the lipid phase in a water bath with temperature adjusted to approximately 60-70° C.
  • the solid substances were suspended into the aqueous p.-.ase and the temperature was adjusted to be the same as that of the lipid phase.
  • the lipid phase was transferred to the ointment mixer vessel, to which vitamin A-palmitate and ⁇ -tocopherol were added.
  • the mixer was turned on and the aqueous phase added, after which they were mixed for about 5 minutes.
  • the dried wheat shoot extract powder was then added and mixed for about 5 minutes, and finally the thyme oil was added and mixed for about 5 minutes, after which Preparation 10 was obtained.
  • the cooling speed of the phases may also be controlled to prevent separation. This can be done by either using a heat jacket around the mixing vessel or by heat infusion, whereby the phase in the mixing vessel remains constantly at the desired temperature.
  • the ointment base used in this case was Celestobase, to which a 3% wheat shoot extract was added instead of sprout extract powder.
  • Preparation 11 Although the ointment obtained in Preparation 11 only contained about half the quantity of extract used in the other preparations, it was still very liquid. It is also possible to use the same amount of extract as in the other preparations, in which case a lotion version of Preparation 11 is obtained.
  • compositions according to the invention were tested by dermal application in human subjects with various skin disorders.
  • Clinical experiments were carried out by local application of the composition on patients twice a day.
  • the patients were men and women of different ages, whose diseases varied from different kinds of eczemas, psoriasis, allergic symptoms, including systemic lupus erythematosus, to various wounds, rheumatoid arthritis and shingles.
  • the appearance and extent and color of the eczema areas were observed and notes kept of each patient's symptoms.
  • composition according to the invention was noted after only a few applications (usually after 2 - 3 days). On average, symptoms in nearly all cases were alleviated in two weeks. Eczema areas had clearly become smaller or totally disappeared, the color of the skin had changed and it was thicker and more supple. In addition to the recovery from eczema and other skin symptoms, the nearly immediate cessation of itching was observed. In most cases, patients remained asymptomatic for a few weeks or even for months after terminating use of composition according to the invention. However, in severe cases of allergy or eczema, other symptoms returned along with the appearance of the allergy upon cessation of treatment.
  • compositions were found to be efficacious in the treatment of all the diseases examined (see above).
  • compositions of the invention were discovered to relieve and cure, among other things, allergic symptoms, Besnier's prurigo, infantile atopic dermatitis and stopic skin, and mild burns and wounds, including serious varicose ulcers.
  • Table 1 provides representative results.
  • compositions according to the invention Approximately 30 additional patients with various skin disorders were treated with compositions according to the invention. Each of those cases showed significant improvement in symptoms after treatment in relation to patients with the same or similar disorders who were not treated with compositions according to the invention. In the most severe cases (severe eczema, blotching, etc.) symptoms returned upon cessation of treatment with compositions according to the invention. However, in no case was treatment with such compositions wholly ineffective. In one case, a 56-year-old female patient diagnosed with Eczema E. farmasis manus et pedis aborum was treated with a composition comprising wheat shoot extract according to the present invention. Although the patient had been treated with cephalosporin, the eczema had become progressively worse.
  • compositions according to the invention also have alleviated symptoms of patients presenting with allergic rashes, acne, chronic dry skin, and allergic reactions characterized by discoloration of the skin. In numerous patients in the aforementioned clinical trials, compositions according to the invention relieved itching associated with the above-mentioned skin disorders. Overall, all patients treated with compositions according to the invention showed substantial improvement in the appearance of the skin and in conditions such as itching and scaling.
  • Tests were conducted to determine the effect of thyme oil on various properties of wheat shoot extract.
  • a cold cream-type ointment was prepared, containing varying quantities of thyme oil.
  • the composition of the ointment was as follows: Lanolin 500 g
  • the ointment was prepared by first mixing the lanolin, almond oil, and thyme oil and then adding wheat shoot extract to the ensuing mixture, thus forming a green, cold cream-type ointment.
  • the ointment was kept in a 10 g dish at room temperature with the lid sealed for 2 or 4 weeks. After storage, the ointment's odor and color were determined, as well as the growth of molds (to determine the extent of degradation). The results are presented in Tables 2 and 3. TABLE 2
  • thyme oil prevents the growth of molds and conceals the unpleasant and strong odor which may result in wheat shoot extract.
  • thyme oil prevents the change in the surface color of a wheat shoot ointment from green to yellow.
  • microbiological purity of wheat shoot extract and lyophilized wheat shoot extract powder was also examined by determining the growth of whole microbes and molds. The tests were carried out in the following manner:
  • the sample to be examined (5 - 10 g) and the required quantity of sterilized phosphate buffer (pH 6.8 - 7.4) and approximately 5% of sterile Tween ® 40 were placed into a sterile lasierlenmeyer. The quantities of the ingredients used were recorded for checking future sample dilution factors. Sample were extracted at about 40 degrees centigrade by frequent shaking over a period of about an hour.
  • Preparation 11 contained only half the quantity of extract used in the other preparations. It is likely that the smaller quantity of extract had an effect on the microbiological purity of that preparation.
  • compositions were kept in closed, nearly full, 50 ml glass dishes at room temperature and at an increased temperature (1 week at 37° C).
  • preparations that were packed in glass dishes were subjected to freezing-melting three times during a week.
  • the preparations that had been subjected to heating and freezing-melting were compared to those that had been kept at room temperature all the time.
  • the following pharmaceutic-technological features were checked: isolation of phases, breakdown of emulsive state, recrystallization or separation of solid substances, as well as the odor of the preparation.

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Abstract

La présente invention concerne des compositions comprenant de l'extrait de germes de blé et/ou de l'huile de thym. Ces compositions servent de produits cosmétiques et pharmaceutiques. Cette invention a aussi pour objet des moyens permettant la préparation de compositions comprenant de l'extrait de germes de blé pour en accroître la stabilité.
PCT/FI1995/000161 1994-03-29 1995-03-27 Composition cosmetique et pharmaceutique a base d'extrait de germes de ble WO1995026183A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU20747/95A AU2074795A (en) 1994-03-29 1995-03-27 Cosmetic and pharmaceutical composition containing wheat shoot extract
FI955718A FI955718A0 (fi) 1994-03-29 1995-11-27 Vehnänorasuutetta sisältävä kosmeettinen ja farmaseuttinen koostumus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21957594A 1994-03-29 1994-03-29
US08/219,575 1994-03-29

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Cited By (5)

* Cited by examiner, † Cited by third party
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FR2755858A1 (fr) * 1996-11-20 1998-05-22 Harajon Isabelle Compositions dermocosmetiques, a base de produits d'origine vegetale et animale et d'essences de plantes, destines, notamment, au traitement de l'erytheme fessier des nouveaux-nes
FR2763504A1 (fr) * 1997-05-21 1998-11-27 Herve Ntsourankoua Pommade cosmetique et pharmaceutique destinee au traitement simultane des gercures, engelures, crevasses, mains abimees et irritations de la peau
EP1353552B1 (fr) * 2001-01-23 2007-02-28 Van Beek Global, LLC Composes et compositions pesticides
WO2008104570A2 (fr) * 2007-03-01 2008-09-04 Labo Cosprophar Ag Formulation visant à accroître l'activité d'un extrait végétal pour usage cosmétique et préparation cosmétique contenant cette formulation
JP2012508707A (ja) * 2008-11-14 2012-04-12 ピエール、ファブレ、デルモ‐コスメティーク 低アレルギー性皮膚用組成物

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FR2755858A1 (fr) * 1996-11-20 1998-05-22 Harajon Isabelle Compositions dermocosmetiques, a base de produits d'origine vegetale et animale et d'essences de plantes, destines, notamment, au traitement de l'erytheme fessier des nouveaux-nes
FR2763504A1 (fr) * 1997-05-21 1998-11-27 Herve Ntsourankoua Pommade cosmetique et pharmaceutique destinee au traitement simultane des gercures, engelures, crevasses, mains abimees et irritations de la peau
EP1353552B1 (fr) * 2001-01-23 2007-02-28 Van Beek Global, LLC Composes et compositions pesticides
WO2008104570A2 (fr) * 2007-03-01 2008-09-04 Labo Cosprophar Ag Formulation visant à accroître l'activité d'un extrait végétal pour usage cosmétique et préparation cosmétique contenant cette formulation
WO2008104570A3 (fr) * 2007-03-01 2008-10-30 Labo Cosprophar Ag Formulation visant à accroître l'activité d'un extrait végétal pour usage cosmétique et préparation cosmétique contenant cette formulation
JP2012508707A (ja) * 2008-11-14 2012-04-12 ピエール、ファブレ、デルモ‐コスメティーク 低アレルギー性皮膚用組成物
US8999402B2 (en) 2008-11-14 2015-04-07 Pierre Fabre Dermo-Cosmetique Hypoallergenic dermatological composition

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