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WO1995011300A3 - Identification et traitement de l'azoospermie - Google Patents

Identification et traitement de l'azoospermie Download PDF

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Publication number
WO1995011300A3
WO1995011300A3 PCT/GB1994/002344 GB9402344W WO9511300A3 WO 1995011300 A3 WO1995011300 A3 WO 1995011300A3 GB 9402344 W GB9402344 W GB 9402344W WO 9511300 A3 WO9511300 A3 WO 9511300A3
Authority
WO
WIPO (PCT)
Prior art keywords
azf
gene
polypeptide
azoospermia
identification
Prior art date
Application number
PCT/GB1994/002344
Other languages
English (en)
Other versions
WO1995011300A2 (fr
Inventor
Ann Chester Chandley
Ma Kun
Andrew Mark Sharkey
Timothy Bruce Hargreave
Howard John Cooke
Original Assignee
Medical Res Council
Ann Chester Chandley
Ma Kun
Andrew Mark Sharkey
Timothy Bruce Hargreave
Howard John Cooke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939321857A external-priority patent/GB9321857D0/en
Priority claimed from GB9413760A external-priority patent/GB9413760D0/en
Application filed by Medical Res Council, Ann Chester Chandley, Ma Kun, Andrew Mark Sharkey, Timothy Bruce Hargreave, Howard John Cooke filed Critical Medical Res Council
Priority to AU79477/94A priority Critical patent/AU7947794A/en
Publication of WO1995011300A2 publication Critical patent/WO1995011300A2/fr
Publication of WO1995011300A3 publication Critical patent/WO1995011300A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention se rapporte à un gène du facteur de l'azoospermie (AZF) (nos d'id. de séquence 1 & 2), à des sondes de polynucléotides se fixant notamment sur ce gène ou sur des variantes de celui-ci survenant naturellement, ainsi qu'à des sondes de polypeptidiques se fixant spécifiquement au polypeptide de l'AZF ou à des variantes de celui-ci survenant naturellement. L'expression de ce gène dans un hôte est également utile pour constituer des moyens servant à évaluer des médicaments destinés à augmenter ou diminuer l'expression du gène de l'AZF ou du polypeptide de l'AZF.
PCT/GB1994/002344 1993-10-22 1994-10-24 Identification et traitement de l'azoospermie WO1995011300A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU79477/94A AU7947794A (en) 1993-10-22 1994-10-24 Azoospermia identification and treatment

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9321857.6 1993-10-22
GB939321857A GB9321857D0 (en) 1993-10-22 1993-10-22 Azoospermia identification treatment
GB9413760.1 1994-07-07
GB9413760A GB9413760D0 (en) 1994-07-07 1994-07-07 Azoospermia identification and treatment

Publications (2)

Publication Number Publication Date
WO1995011300A2 WO1995011300A2 (fr) 1995-04-27
WO1995011300A3 true WO1995011300A3 (fr) 1995-07-20

Family

ID=26303732

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1994/002344 WO1995011300A2 (fr) 1993-10-22 1994-10-24 Identification et traitement de l'azoospermie

Country Status (2)

Country Link
AU (1) AU7947794A (fr)
WO (1) WO1995011300A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840549A (en) * 1995-06-07 1998-11-24 Promega Corporation Male infertility Y-deletion detection battery
US5783390A (en) * 1995-06-07 1998-07-21 Promega Corporation Male infertility Y-deletion detection battery
WO1998046747A2 (fr) * 1997-04-11 1998-10-22 Whitehead Institute For Biomedical Research Genes de la region de non-recombinaison du chromosome y

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
K. MA ET AL.: "Towards the molecular localisation of the AZF locus: mapping of microdeletions in azoospermic men within 14 subintervals of interval 6 of the human Y chromosome", HUMAN MOLECULAR GENETICS, vol. 1, no. 1, April 1992 (1992-04-01), pages 29 - 33 *
KUN MA ET AL.: "A Y chromosome gene family with RNA-binding protein homology: Candidates for the azoospermia factr AZF controlling human spermatogenesis", CELL, vol. 75, no. 7, 31 December 1993 (1993-12-31), CAMBRIDGE, NA US, pages 1287 - 1295 *
VOGT P. ET AL.: "Towards the molecular localization of AZF, a male infertility gene on the human Y chromosome by comparative mapping of microdeletions in the Y chromosome of men with idiopathic infertility", PROCEEDINGS OF THE 8TH INTERNATIONAL CONGRESS OF HUMAN GENETICS, vol. 49, no. 4, October 1991 (1991-10-01), WASHINGTON, D.C., U.S.A., pages 390 *

Also Published As

Publication number Publication date
AU7947794A (en) 1995-05-08
WO1995011300A2 (fr) 1995-04-27

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