+

WO1995011300A3 - Azoospermia identification and treatment - Google Patents

Azoospermia identification and treatment Download PDF

Info

Publication number
WO1995011300A3
WO1995011300A3 PCT/GB1994/002344 GB9402344W WO9511300A3 WO 1995011300 A3 WO1995011300 A3 WO 1995011300A3 GB 9402344 W GB9402344 W GB 9402344W WO 9511300 A3 WO9511300 A3 WO 9511300A3
Authority
WO
WIPO (PCT)
Prior art keywords
azf
gene
polypeptide
azoospermia
identification
Prior art date
Application number
PCT/GB1994/002344
Other languages
French (fr)
Other versions
WO1995011300A2 (en
Inventor
Ann Chester Chandley
Ma Kun
Andrew Mark Sharkey
Timothy Bruce Hargreave
Howard John Cooke
Original Assignee
Medical Res Council
Ann Chester Chandley
Ma Kun
Andrew Mark Sharkey
Timothy Bruce Hargreave
Howard John Cooke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939321857A external-priority patent/GB9321857D0/en
Priority claimed from GB9413760A external-priority patent/GB9413760D0/en
Application filed by Medical Res Council, Ann Chester Chandley, Ma Kun, Andrew Mark Sharkey, Timothy Bruce Hargreave, Howard John Cooke filed Critical Medical Res Council
Priority to AU79477/94A priority Critical patent/AU7947794A/en
Publication of WO1995011300A2 publication Critical patent/WO1995011300A2/en
Publication of WO1995011300A3 publication Critical patent/WO1995011300A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides an AZF gene (seq ID Nos 1 & 2), and polynucleotide probes specifically binding to this gene or to naturally occurring variants thereof, as well as polypeptide probes specifically binding to the AZF polypeptide or to naturally occurring variants thereof. Expression of the gene in a host is also useful for providing means for use in the evaluation of drugs for use in increasing or decreasing expression of the AZF gene or AZF polypeptide.
PCT/GB1994/002344 1993-10-22 1994-10-24 Azoospermia identification and treatment WO1995011300A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU79477/94A AU7947794A (en) 1993-10-22 1994-10-24 Azoospermia identification and treatment

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9321857.6 1993-10-22
GB939321857A GB9321857D0 (en) 1993-10-22 1993-10-22 Azoospermia identification treatment
GB9413760A GB9413760D0 (en) 1994-07-07 1994-07-07 Azoospermia identification and treatment
GB9413760.1 1994-07-07

Publications (2)

Publication Number Publication Date
WO1995011300A2 WO1995011300A2 (en) 1995-04-27
WO1995011300A3 true WO1995011300A3 (en) 1995-07-20

Family

ID=26303732

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1994/002344 WO1995011300A2 (en) 1993-10-22 1994-10-24 Azoospermia identification and treatment

Country Status (2)

Country Link
AU (1) AU7947794A (en)
WO (1) WO1995011300A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840549A (en) * 1995-06-07 1998-11-24 Promega Corporation Male infertility Y-deletion detection battery
US5783390A (en) * 1995-06-07 1998-07-21 Promega Corporation Male infertility Y-deletion detection battery
WO1998046747A2 (en) * 1997-04-11 1998-10-22 Whitehead Institute For Biomedical Research Genes in the non-recombining region of the y chromosome

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
K. MA ET AL.: "Towards the molecular localisation of the AZF locus: mapping of microdeletions in azoospermic men within 14 subintervals of interval 6 of the human Y chromosome", HUMAN MOLECULAR GENETICS, vol. 1, no. 1, April 1992 (1992-04-01), pages 29 - 33 *
KUN MA ET AL.: "A Y chromosome gene family with RNA-binding protein homology: Candidates for the azoospermia factr AZF controlling human spermatogenesis", CELL, vol. 75, no. 7, 31 December 1993 (1993-12-31), CAMBRIDGE, NA US, pages 1287 - 1295 *
VOGT P. ET AL.: "Towards the molecular localization of AZF, a male infertility gene on the human Y chromosome by comparative mapping of microdeletions in the Y chromosome of men with idiopathic infertility", PROCEEDINGS OF THE 8TH INTERNATIONAL CONGRESS OF HUMAN GENETICS, vol. 49, no. 4, October 1991 (1991-10-01), WASHINGTON, D.C., U.S.A., pages 390 *

Also Published As

Publication number Publication date
WO1995011300A2 (en) 1995-04-27
AU7947794A (en) 1995-05-08

Similar Documents

Publication Publication Date Title
CA2181548A1 (en) Zinc finger protein derivatives and methods therefor
WO1994001548A3 (en) Human nucleic acid fragments, isolated from brain adrenal tissue, placenta or bone narrow
WO1998055607A3 (en) Tumor targeted vector
AU670843B2 (en) Methods for sequencing synthetic oligonucleotides containing non-phosphodiester internucleotide linkages
EP1005540A4 (en) Ikk-beta proteins, nucleic acids and methods
CA2295999A1 (en) Nik proteins, nucleic acids and methods
WO1999053061A3 (en) Tumor associated nucleic acids and uses therefor
CA2177827A1 (en) Novel apoptosis-modulating proteins, dna encoding the proteins and methods of use thereof
IL135688A0 (en) Human checkpoint kinase, hcds1, compositions and methods
AR244544A1 (en) Amino acid beta-lyase enzyme inhibitors as deodorants
EP1449849A3 (en) Protease-resistant thrombomodulin analog
EP1005539A4 (en) IKK-$g(a) PROTEINS, NUCLEIC ACIDS AND METHODS
EP1037999A4 (en) Porphorymonas gingivalis polypeptides and nucleotides
AU7001994A (en) Mutant polypeptide of protein kinase c, nucleic acid sequences coding for said polypeptide and use thereof
EP0614970A3 (en) Hydroxyphenylpyruvate-dioxygenase inhibitors and assay for the identification of the enzyme.
WO1995011300A3 (en) Azoospermia identification and treatment
EP0363436A4 (en) Cloned protein g variant genes and the protein g variants expressed therefrom.
EP1146124A3 (en) Gustducin materials and methods
EP0816504A3 (en) Platelet activating factor acetylhdrolase, and gene thereof
IL98273A0 (en) Dna sequences,proteins having esterase activity coded by them,and use of such proteins
WO1994029447A3 (en) Dna coding for the human thyrotropin-releasing hormone receptor
EP1260228A3 (en) Human growth gene and short stature gene region. Therapeutic uses
EP0732398A4 (en) Novel tyrosine kinase
ATE312179T1 (en) AGENT CONTAINING SERINE-THREONINE KINASE FOR TUMOR THERAPY AND TUMOR DIAGNOSIS
CA2135200A1 (en) Canine coronavirus s gene and uses therefor

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU JP KE KG KP KR KZ LK LR LT LU LV MD MG MN MW NL NO NZ PL PT RO RU SD SE SI SK TJ TT UA US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): KE MW SD SZ AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU JP KE KG KP KR KZ LK LR LT LU LV MD MG MN MW NL NO NZ PL PT RO RU SD SE SI SK TJ TT UA US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): KE MW SD SZ AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载