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WO1995006764A3 - Oligonucleotides ayant une activite de segmentation de l'arn - Google Patents

Oligonucleotides ayant une activite de segmentation de l'arn Download PDF

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Publication number
WO1995006764A3
WO1995006764A3 PCT/IB1994/000288 IB9400288W WO9506764A3 WO 1995006764 A3 WO1995006764 A3 WO 1995006764A3 IB 9400288 W IB9400288 W IB 9400288W WO 9506764 A3 WO9506764 A3 WO 9506764A3
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WO
WIPO (PCT)
Prior art keywords
oligonucleotides
cleavage activity
rna cleavage
rna
activity
Prior art date
Application number
PCT/IB1994/000288
Other languages
English (en)
Other versions
WO1995006764A2 (fr
Inventor
Larry W Mclaughlin
Dong-Jing Fu
Fritz Benseler
Gerd Kotzorek
Janos Ludwig
Original Assignee
Ribonetics Gmbh
Larry W Mclaughlin
Fu Dong Jing
Fritz Benseler
Gerd Kotzorek
Janos Ludwig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribonetics Gmbh, Larry W Mclaughlin, Fu Dong Jing, Fritz Benseler, Gerd Kotzorek, Janos Ludwig filed Critical Ribonetics Gmbh
Priority to AU76231/94A priority Critical patent/AU7623194A/en
Publication of WO1995006764A2 publication Critical patent/WO1995006764A2/fr
Publication of WO1995006764A3 publication Critical patent/WO1995006764A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3183—Diol linkers, e.g. glycols or propanediols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3527—Other alkyl chain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3535—Nitrogen

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention se rapporte à de nouveaux oligonucléotides, notamment aux oligonucléotides ayant une activité de segmentation de l'ARN.
PCT/IB1994/000288 1993-09-03 1994-09-05 Oligonucleotides ayant une activite de segmentation de l'arn WO1995006764A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU76231/94A AU7623194A (en) 1993-09-03 1994-09-05 Oligonucleotides with rna cleavage activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11629193A 1993-09-03 1993-09-03
US08/116,291 1993-09-03

Publications (2)

Publication Number Publication Date
WO1995006764A2 WO1995006764A2 (fr) 1995-03-09
WO1995006764A3 true WO1995006764A3 (fr) 1995-10-19

Family

ID=22366298

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1994/000288 WO1995006764A2 (fr) 1993-09-03 1994-09-05 Oligonucleotides ayant une activite de segmentation de l'arn

Country Status (2)

Country Link
AU (1) AU7623194A (fr)
WO (1) WO1995006764A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998193A (en) * 1994-06-24 1999-12-07 Gene Shears Pty., Ltd. Ribozymes with optimized hybridizing arms, stems, and loops, tRNA embedded ribozymes and compositions thereof
US5716824A (en) * 1995-04-20 1998-02-10 Ribozyme Pharmaceuticals, Inc. 2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
US6277634B1 (en) * 1995-06-07 2001-08-21 Commonwealth Scientific And Industrial Research Organization Optimized minizymes and miniribozymes and uses thereof
US6127159A (en) 1997-06-06 2000-10-03 The Board Of Trustees Of The Leland Stanford Junior University Mitofusin genes and their uses
PT1119349E (pt) 1998-08-18 2008-10-14 Univ California Antagonistas de receptor de factor de crescimento epidérmico para tratamento de hipersecreção de muco nos pulmões
US6379931B1 (en) * 1999-08-12 2002-04-30 City Of Hope Chimeric DNA/RNA ribozymes containing propanediol
WO2001025274A1 (fr) 1999-10-06 2001-04-12 The Board Of Trustees Of The Leland Stanford Junior University Mitofusines, homologues fzo, et derives fonctionnels de celles-ci
AU785425B2 (en) 2001-03-30 2007-05-17 Genetic Technologies Limited Methods of genomic analysis
JP2005516917A (ja) 2001-12-12 2005-06-09 アメリカ合衆国 細胞外アデノシン阻害剤およびアデノシン受容体阻害剤を用いて免疫応答および炎症を増強するための方法
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
EP1958964A3 (fr) 2004-02-24 2009-01-07 The Government of the United States of America, as represented by The Secretary, Department of Health and Human Services RAB9A, RAB11A, et modulateurs correspondants liés à une maladie infectieuse
US20090087854A1 (en) 2007-09-27 2009-04-02 Perlegen Sciences, Inc. Methods for genetic analysis
EP1812597A2 (fr) 2004-10-27 2007-08-01 Vanderbilt University Genes mammaliens intervenant dans une infection
EP2029157A4 (fr) 2006-05-19 2009-11-18 Georgia Tech Res Inst Ligand des transporteurs abc
WO2008008873A2 (fr) 2006-07-14 2008-01-17 Georgia Tech Research Corporation Ligand du canal clc
WO2012102793A2 (fr) 2010-12-10 2012-08-02 Zirus, Inc. Gènes de mammifère impliqués dans la toxicité et l'infection
WO2016025629A1 (fr) 2014-08-12 2016-02-18 The Regents Of The University Of California Composition moléculaire permettant d'améliorer et de renouveler l'entretien et la réparation des tissus de mammifère
AU2016265948B2 (en) 2015-05-18 2018-12-06 Alkahest, Inc. Methods and compositions for treating aging-associated impairments

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007065A1 (fr) * 1990-10-12 1992-04-30 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Ribozymes modifies
WO1993015187A1 (fr) * 1992-01-31 1993-08-05 Massachusetts Institute Of Technology Nucleoenzymes
WO1994013789A2 (fr) * 1992-12-04 1994-06-23 Ribonetics Gmbh Oligonucleotides presentant une activite de clivage de l'arn
WO1994013793A1 (fr) * 1992-12-04 1994-06-23 Apollon, Inc. Composes et methodes de traitement des leucemies
WO1994013688A1 (fr) * 1992-12-08 1994-06-23 Gene Shears Pty. Limited Ribozymes avec bras d'adn et minizymes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007065A1 (fr) * 1990-10-12 1992-04-30 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Ribozymes modifies
WO1993015187A1 (fr) * 1992-01-31 1993-08-05 Massachusetts Institute Of Technology Nucleoenzymes
WO1994013789A2 (fr) * 1992-12-04 1994-06-23 Ribonetics Gmbh Oligonucleotides presentant une activite de clivage de l'arn
WO1994013793A1 (fr) * 1992-12-04 1994-06-23 Apollon, Inc. Composes et methodes de traitement des leucemies
WO1994013688A1 (fr) * 1992-12-08 1994-06-23 Gene Shears Pty. Limited Ribozymes avec bras d'adn et minizymes

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
D. B. OLSEN ET AL.: "Study of a hammerhead ribozyme containing 2'-modified adenosine residues", BIOCHEMISTRY, vol. 30, pages 9735 - 41 *
D. M. WILLIAMS ET AL.: "Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2'-modifications", P.N.A.S., vol. 89, pages 918 - 21 *
F. BENSELER ET AL.: "Hammerhead-like molecules containing non-nucleoside linkers are active RNA catalysts", J. AM. CHEM. SOC., vol. 115, pages 8483 - 4 *
M. Y.-X. MA ET AL.: "Design and Synthesis of RNA miniduplexes via a synthetic linker approach", BIOCHEMISTRY, vol. 32, pages 1751 - 58 *
O. HEIDENREICH, F. ECKSTEIN: "Hammerhead ribozyme-mediated cleavage of the long terminal repeat RNA of human immunodeficiency virus type I", J. BIOL. CHEM., vol. 267, pages 1904 - 9 *
W. A. PIEKEN ET AL.: "Kinetic characterization of ribonuclease-resistant 2'-modified hammerhead-ribozymes", SCIENCE, vol. 253, pages 314 - 7 *

Also Published As

Publication number Publication date
AU7623194A (en) 1995-03-22
WO1995006764A2 (fr) 1995-03-09

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