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WO1994008578A3 - Activite tumoricide des ansamycines benzoquinonoides contre le cancer de la prostate et les malignites neurales primitives - Google Patents

Activite tumoricide des ansamycines benzoquinonoides contre le cancer de la prostate et les malignites neurales primitives Download PDF

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Publication number
WO1994008578A3
WO1994008578A3 PCT/US1993/009858 US9309858W WO9408578A3 WO 1994008578 A3 WO1994008578 A3 WO 1994008578A3 US 9309858 W US9309858 W US 9309858W WO 9408578 A3 WO9408578 A3 WO 9408578A3
Authority
WO
WIPO (PCT)
Prior art keywords
malignancies
prostate cancer
against prostate
tumoricidal activity
primitive neural
Prior art date
Application number
PCT/US1993/009858
Other languages
English (en)
Other versions
WO1994008578A2 (fr
Inventor
Luke Whitesell
Leonard Neckers
Jane Trepel
Charles Myers
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Priority to EP93923891A priority Critical patent/EP0664702A1/fr
Priority to CA002146668A priority patent/CA2146668A1/fr
Priority to AU53606/94A priority patent/AU5360694A/en
Priority to JP6510285A priority patent/JPH08502488A/ja
Publication of WO1994008578A2 publication Critical patent/WO1994008578A2/fr
Publication of WO1994008578A3 publication Critical patent/WO1994008578A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procédés et compositions pour le traitement de certains malignités chez l'homme, comprenant l'utilisation de certains ansamycine-benzoquinones.
PCT/US1993/009858 1992-10-14 1993-10-14 Activite tumoricide des ansamycines benzoquinonoides contre le cancer de la prostate et les malignites neurales primitives WO1994008578A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP93923891A EP0664702A1 (fr) 1992-10-14 1993-10-14 Activite tumoricide des ansamycines benzoquinonoides contre le cancer de la prostate et les malignites neurales primitives
CA002146668A CA2146668A1 (fr) 1992-10-14 1993-10-14 Activite tumoricide d'ansamycines benzoquinonoides contre le cancer de la prostate et les tumeurs malignes primitives du systeme nerveux
AU53606/94A AU5360694A (en) 1992-10-14 1993-10-14 Tumoricidal activity of benzoquinonoid ansamycins against prostate cancer and primitive neural malignancies
JP6510285A JPH08502488A (ja) 1992-10-14 1993-10-14 前立腺癌および初期神経悪性疾患に対するベンゾキノイドアンサマイシンの殺腫瘍活性

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96125092A 1992-10-14 1992-10-14
US07/961,250 1992-10-14

Publications (2)

Publication Number Publication Date
WO1994008578A2 WO1994008578A2 (fr) 1994-04-28
WO1994008578A3 true WO1994008578A3 (fr) 1994-06-23

Family

ID=25504242

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/009858 WO1994008578A2 (fr) 1992-10-14 1993-10-14 Activite tumoricide des ansamycines benzoquinonoides contre le cancer de la prostate et les malignites neurales primitives

Country Status (5)

Country Link
EP (1) EP0664702A1 (fr)
JP (1) JPH08502488A (fr)
AU (1) AU5360694A (fr)
CA (1) CA2146668A1 (fr)
WO (1) WO1994008578A2 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0974052B1 (fr) * 1997-04-02 2004-06-30 Takeda Chemical Industries, Ltd. Substances pour corriger la fonction d'un produit genique aberrant
AU3378599A (en) * 1998-04-03 1999-10-25 University Of Pittsburgh Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke
WO2000045805A2 (fr) * 1999-02-08 2000-08-10 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methodes d'inhibition du reseau de hgf-met-upa-plasmine
US6174875B1 (en) 1999-04-01 2001-01-16 University Of Pittsburgh Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke
US7312244B2 (en) 1999-04-30 2007-12-25 Cellgate, Inc. Polyamine analog-amino acid conjugates useful as anticancer agents
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
WO2000066175A2 (fr) 1999-04-30 2000-11-09 Slil Biomedical Corporation Nouveaux conjugues d'analogue de polyamine et conjugues de quinone, utilises pour le traitement de cancers et de maladies de la prostate
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
WO2005009345A2 (fr) 2003-06-13 2005-02-03 Kosan Biosciences, Inc. Composes de 2-desmethyl ansamycine
US6855705B1 (en) 2003-11-12 2005-02-15 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6887993B1 (en) 2003-11-12 2005-05-03 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
WO2005056531A1 (fr) 2003-11-12 2005-06-23 Kosan Biosciences, Inc. Composes 11-o-methylgeldanamycine
US6875863B1 (en) 2003-11-12 2005-04-05 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
EP1737825A1 (fr) * 2004-03-26 2007-01-03 Van Andel Research Institute Geldanamycine et ses derives pouvant inhiber une proliferation cancereuse et identifier de nouvelles cibles
US7259156B2 (en) 2004-05-20 2007-08-21 Kosan Biosciences Incorporated Geldanamycin compounds and method of use
US7608611B2 (en) * 2005-03-11 2009-10-27 The Regents Of The University Of Colorado Hsp90 inhibitors, methods of making and uses therefor
CN101213178A (zh) * 2005-06-29 2008-07-02 协和发酵工业株式会社 苯环型安莎霉素衍生物
GB0606554D0 (en) * 2006-03-31 2006-05-10 Biotica Tech Ltd Novel compounds and methods for their production
GB0606542D0 (en) * 2006-03-31 2006-05-10 Biotica Tech Ltd Novel compounds and methods for their production
GB0609117D0 (en) * 2006-05-09 2006-06-21 Biotica Tech Ltd Novel compounds
CA2669820A1 (fr) * 2006-11-15 2008-05-22 Abraxis Bioscience, Llc Derives d'analogues de l'hydroquinone de geldamycine substitues par 18-amino presentant une activite cytotoxique pour le traitement du cancer
WO2009026548A1 (fr) 2007-08-23 2009-02-26 The Regents Of The University Of Colorado Inhibiteurs de hsp90 avec toxicité modifiée
CN101854955B (zh) 2007-09-10 2012-07-18 马萨诸塞大学 靶向线粒体的抗肿瘤剂
US9603829B2 (en) 2011-11-14 2017-03-28 The Regents Of The University Of Colorado, A Body Corporate HSP90 inhibitors with modified toxicity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2042523A (en) * 1979-02-19 1980-09-24 Kaken Chemical Co Geldanamycin derivatives and anti-tumor drug
DE3234203A1 (de) * 1981-09-17 1983-07-07 Takeda Chemical Industries, Ltd., Osaka Macbecin-derivate und deren herstellung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2042523A (en) * 1979-02-19 1980-09-24 Kaken Chemical Co Geldanamycin derivatives and anti-tumor drug
DE3234203A1 (de) * 1981-09-17 1983-07-07 Takeda Chemical Industries, Ltd., Osaka Macbecin-derivate und deren herstellung

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
L.WHITESELL ET AL.: "Benzoquinonoid Ansamycins Possess Selective Tumoricidal Activity Unrelated to src Kinase Inhibition", CANCER RES., vol. 52, no. 7, 1 April 1992 (1992-04-01), pages 1721 - 1728 *
M. MATSUMOTO: "Inhibitors for Protein Tyrosine Kinases, Erbstatin, Genistein and Hernimycin A, Induce Differentiation of Human Neural Tumor Cell Lines", NIPPON GEKA HOKAN (ARCH. JPN. CHIR.), vol. 60, no. 2, 1 March 1991 (1991-03-01), pages 113 - 121 *
P.N.PREIS ET AL.: "Neuronal Cell Differentiation of Human Neuroblastoma Cells by Retinoic Acid plus Herbimycin A", CANCER RES., vol. 48, no. 22, 15 November 1988 (1988-11-15), pages 6530 - 6534 *

Also Published As

Publication number Publication date
AU5360694A (en) 1994-05-09
JPH08502488A (ja) 1996-03-19
EP0664702A1 (fr) 1995-08-02
WO1994008578A2 (fr) 1994-04-28
CA2146668A1 (fr) 1994-04-28

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