+

WO1994008578A3 - Tumoricidal activity of benzoquinonoid ansamycins against prostate cancer and primitive neural malignancies - Google Patents

Tumoricidal activity of benzoquinonoid ansamycins against prostate cancer and primitive neural malignancies Download PDF

Info

Publication number
WO1994008578A3
WO1994008578A3 PCT/US1993/009858 US9309858W WO9408578A3 WO 1994008578 A3 WO1994008578 A3 WO 1994008578A3 US 9309858 W US9309858 W US 9309858W WO 9408578 A3 WO9408578 A3 WO 9408578A3
Authority
WO
WIPO (PCT)
Prior art keywords
malignancies
prostate cancer
against prostate
tumoricidal activity
primitive neural
Prior art date
Application number
PCT/US1993/009858
Other languages
French (fr)
Other versions
WO1994008578A2 (en
Inventor
Luke Whitesell
Leonard Neckers
Jane Trepel
Charles Myers
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Priority to EP93923891A priority Critical patent/EP0664702A1/en
Priority to AU53606/94A priority patent/AU5360694A/en
Priority to JP6510285A priority patent/JPH08502488A/en
Priority to CA002146668A priority patent/CA2146668A1/en
Publication of WO1994008578A2 publication Critical patent/WO1994008578A2/en
Publication of WO1994008578A3 publication Critical patent/WO1994008578A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

The invention provides methods and compositions for treating selected human malignancies including use of certain ansamycin benzoquinones.
PCT/US1993/009858 1992-10-14 1993-10-14 Tumoricidal activity of benzoquinonoid ansamycins against prostate cancer and primitive neural malignancies WO1994008578A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP93923891A EP0664702A1 (en) 1992-10-14 1993-10-14 Tumoricidal activity of benzoquinonoid ansamycins against prostate cancer and primitive neural malignancies
AU53606/94A AU5360694A (en) 1992-10-14 1993-10-14 Tumoricidal activity of benzoquinonoid ansamycins against prostate cancer and primitive neural malignancies
JP6510285A JPH08502488A (en) 1992-10-14 1993-10-14 Tumoricidal activity of benzoquinoid ansamycin against prostate cancer and early neurological malignancies
CA002146668A CA2146668A1 (en) 1992-10-14 1993-10-14 Tumoricidal activity of benzoquinonoid ansamycins against prostate cancer and primitive neural malignancies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96125092A 1992-10-14 1992-10-14
US07/961,250 1992-10-14

Publications (2)

Publication Number Publication Date
WO1994008578A2 WO1994008578A2 (en) 1994-04-28
WO1994008578A3 true WO1994008578A3 (en) 1994-06-23

Family

ID=25504242

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/009858 WO1994008578A2 (en) 1992-10-14 1993-10-14 Tumoricidal activity of benzoquinonoid ansamycins against prostate cancer and primitive neural malignancies

Country Status (5)

Country Link
EP (1) EP0664702A1 (en)
JP (1) JPH08502488A (en)
AU (1) AU5360694A (en)
CA (1) CA2146668A1 (en)
WO (1) WO1994008578A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2284264A1 (en) * 1997-04-02 1998-10-08 Takeda Chemical Industries, Ltd. Substances to correct aberrant gene product fonction
AU3378599A (en) * 1998-04-03 1999-10-25 University Of Pittsburgh Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke
WO2000045805A2 (en) * 1999-02-08 2000-08-10 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methods of inhibiting the hgf-met-upa-plasmin network with geldanamycin derivates
US6174875B1 (en) 1999-04-01 2001-01-16 University Of Pittsburgh Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
JP2002543163A (en) 1999-04-30 2002-12-17 スリル バイオメディカル コーポレイション Conjugates as treatments for cancer and prostate disease
WO2002091989A2 (en) 2000-11-08 2002-11-21 Slil Biomedical Corporation Antiviral therapies using polyamine or polyamine analog-amino acid conjugates
WO2005009345A2 (en) 2003-06-13 2005-02-03 Kosan Biosciences, Inc. 2-desmethyl ansamycin compounds
US6855705B1 (en) 2003-11-12 2005-02-15 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
WO2005056531A1 (en) 2003-11-12 2005-06-23 Kosan Biosciences, Inc. 11-o-methylgeldanamycin compounds
US6887993B1 (en) 2003-11-12 2005-05-03 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6875863B1 (en) 2003-11-12 2005-04-05 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
EP1737825A1 (en) * 2004-03-26 2007-01-03 Van Andel Research Institute Geldanamycin and derivatives inhibit cancer invasion and identify novel targets
US7259156B2 (en) 2004-05-20 2007-08-21 Kosan Biosciences Incorporated Geldanamycin compounds and method of use
US7608611B2 (en) * 2005-03-11 2009-10-27 The Regents Of The University Of Colorado Hsp90 inhibitors, methods of making and uses therefor
EP2361903A1 (en) * 2005-06-29 2011-08-31 Kyowa Hakko Kirin Co., Ltd. Benzenoid ansamycin derivative
GB0606542D0 (en) * 2006-03-31 2006-05-10 Biotica Tech Ltd Novel compounds and methods for their production
GB0606554D0 (en) * 2006-03-31 2006-05-10 Biotica Tech Ltd Novel compounds and methods for their production
GB0609117D0 (en) * 2006-05-09 2006-06-21 Biotica Tech Ltd Novel compounds
ES2367876T3 (en) * 2006-11-15 2011-11-10 Abraxis Bioscience, Llc DERIVATIVES OF 18-AMINO ANALOGS REPLACED FROM GELDAMICINE HYDROQUINONE WITH CYTOTOXIC ACTIVITY FOR CANCER TREATMENT.
US8551964B2 (en) 2007-08-23 2013-10-08 The Regents Of The University Of Colorado Hsp90 inhibitors with modified toxicity
EP2200653A2 (en) 2007-09-10 2010-06-30 University of Massachusetts Mitochondria-targeted anti-tumour agents
WO2013074695A1 (en) 2011-11-14 2013-05-23 The Regents Of The University Of Colorado, A Body Corporate Hsp90 inhibitors with modified toxicity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2042523A (en) * 1979-02-19 1980-09-24 Kaken Chemical Co Geldanamycin derivatives and anti-tumor drug
DE3234203A1 (en) * 1981-09-17 1983-07-07 Takeda Chemical Industries, Ltd., Osaka MACBECIN DERIVATIVES AND THEIR PRODUCTION

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2042523A (en) * 1979-02-19 1980-09-24 Kaken Chemical Co Geldanamycin derivatives and anti-tumor drug
DE3234203A1 (en) * 1981-09-17 1983-07-07 Takeda Chemical Industries, Ltd., Osaka MACBECIN DERIVATIVES AND THEIR PRODUCTION

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
L.WHITESELL ET AL.: "Benzoquinonoid Ansamycins Possess Selective Tumoricidal Activity Unrelated to src Kinase Inhibition", CANCER RES., vol. 52, no. 7, 1 April 1992 (1992-04-01), pages 1721 - 1728 *
M. MATSUMOTO: "Inhibitors for Protein Tyrosine Kinases, Erbstatin, Genistein and Hernimycin A, Induce Differentiation of Human Neural Tumor Cell Lines", NIPPON GEKA HOKAN (ARCH. JPN. CHIR.), vol. 60, no. 2, 1 March 1991 (1991-03-01), pages 113 - 121 *
P.N.PREIS ET AL.: "Neuronal Cell Differentiation of Human Neuroblastoma Cells by Retinoic Acid plus Herbimycin A", CANCER RES., vol. 48, no. 22, 15 November 1988 (1988-11-15), pages 6530 - 6534 *

Also Published As

Publication number Publication date
CA2146668A1 (en) 1994-04-28
AU5360694A (en) 1994-05-09
EP0664702A1 (en) 1995-08-02
JPH08502488A (en) 1996-03-19
WO1994008578A2 (en) 1994-04-28

Similar Documents

Publication Publication Date Title
WO1994008578A3 (en) Tumoricidal activity of benzoquinonoid ansamycins against prostate cancer and primitive neural malignancies
AU2592600A (en) Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
IL189132A0 (en) Pharmaceutical compositions for the treatment of prostate hypertrophy and prostate cancer
AU6276194A (en) Use of monoterpenes, sesquiterpernes and diterpernes for the treatment of cancer
HUP9902068A3 (en) Methods and compositions for the diagnosis and treatment of cancer
HK1022301A1 (en) Conjugates of cisdocosahexaenoic acid and paclitaxel
ZA957483B (en) Compounds and methods for the treatment of cancer
WO1996035784A3 (en) Chromatin-regulator genes
GB2344532A (en) Electromagnetic radiation therapy
WO1999015167A3 (en) Use of citrus limonoids and flavonoids as well as tocotrienols for the treatment of cancer
AU7012496A (en) Compounds and methods for treatment and diagnosis of prostate cancer
MX9707570A (en) USE OF 'alpha'1L AGONISTS IN THE TREATMENT OF INCONTINENCE.
PL323798A1 (en) Application of derivatives of vitamin d4 in treating skin diseases
PL328858A1 (en) Immunogenous peptides
AU4473596A (en) Methods of human prostate cancer diagnosis
NZ297040A (en) Mono- or polyfunctional polylysine conjugates
ZA973622B (en) Use of forms of hyaluronic acid (HA) for the treatment of cancer.
WO1998030585A3 (en) Use of pea3 in tumor suppression
AU2476200A (en) Ribozyme therapy for the treatment and/or prevention of restenosis
IL101410A0 (en) Formulation for the treatment of cancer
BG102667A (en) Diosgenine-containing composition
CA2282682A1 (en) Tazarotene and corticosteroid treatment for psoriasis
AU7105498A (en) Combination therapy for the prevention and treatment of osteoporosis
AU1278600A (en) Novel therapeutic application of nicergoline
EP0733365A3 (en) Use of benzoquinolin-3-ones for the treatment and prevention of prostatic cancer

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2146668

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1993923891

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1993923891

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1993923891

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载