+

WO1993017723A1 - Desinfectant de surfaces biodegradable - Google Patents

Desinfectant de surfaces biodegradable Download PDF

Info

Publication number
WO1993017723A1
WO1993017723A1 PCT/US1993/001695 US9301695W WO9317723A1 WO 1993017723 A1 WO1993017723 A1 WO 1993017723A1 US 9301695 W US9301695 W US 9301695W WO 9317723 A1 WO9317723 A1 WO 9317723A1
Authority
WO
WIPO (PCT)
Prior art keywords
percent
weight
alcohol
surface disinfectant
surfactant
Prior art date
Application number
PCT/US1993/001695
Other languages
English (en)
Inventor
Paul L. Simmons
Original Assignee
Simmons Paul L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Simmons Paul L filed Critical Simmons Paul L
Priority to AU37782/93A priority Critical patent/AU3778293A/en
Publication of WO1993017723A1 publication Critical patent/WO1993017723A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/06—Inactivation or attenuation by chemical treatment

Definitions

  • a non-toxic hypocompatible biodegradable surface disinfectant effective against a wide range of pathogenic organisms.
  • cleaners include a germicide so that the surface is disinfected.
  • Common disinfecting compounds used in cleaners are the quaternary ammonium compounds, phenols and alcohols.
  • U.S, 4,689,168 describes a hard surface cleaning composition suitable for glass, chrome, plastic, enamel and other hard surfaces.
  • the composition is applied to the hard surface as an emulsion of an aqueous phase and an oil phase.
  • the bubbling action is caused by the evaporation of volatile constituents from the film or layer of applied compositions, as well as the desire for the aqueous and oil phase components to reform.
  • the bubbling action characterized by small bubbles of volatile components erupting from the surface of the composition film aids in lifting soil from the hard surface. As an apparent consequence, the rate of cleaning is accelerated.
  • the composition comprises a polar organic solvent or mixture of solvents, a nonvolatile surfactant, a volatile surfactant such asn an acetylenic alcohol or diol, a volatile organosiloxane oligomer and water.
  • U.S. 4,983,317 teaches a liquid composition for cleaning a wide variety of hard surfaces,. particularly metallic, plastic, tile, porcelain, glass and mirrored surfaces comprising a polyacrylic acid or a polyacrylate resin builder in combination with a hydrotrope which is an alkali metal salt of a C ⁇ . dicarboxylic acid.
  • the organic solvent may be selected from the group consisting of alk lene and polyalkylene glycols of from 2 to 6 carbon atoms and lower alkyl ethers of alkylene and polyalkylene glycols of from 3 to 8 carbon atoms, the alkyl ether having from 1 to 4 carbon atoms.
  • a lower aliphatic alcohol of from 2 to 4 carbon atoms may also be included in the composition to adjust evaporation rate of the composition.
  • U.S. 5,064,635 describes a mixture of one or more surfactants (detergents) with the pH sensitive dye.
  • the surfactant can be diluted with water to give the desired cleaning strength.
  • the surfactant can be an anionic, nonionic, amphoteric or mixtures of the three types.
  • Typical anionic surfactants used are petroleum sulfonates, such as sodium dodecylbenzene sulfonate, alcohol sulfates such as sodium lauryl sulfate and ethoxylated higher fatty alcohol sulfates such as sodium lauryl ether sulfate.
  • Typical nonionic surfactants are primary alcohol ethoxylates, secondary alcohol ethoxylates, alkyl phenol ethoxylates and alkanolamides.
  • the amphoteric surfactants include a number of types of carboxylates derived from fatty imidazolines such as sodium dicarboxyethylcoco phosphoethyl imidazoline or fatty proprionates such as cocoamphoproprionate or cocoamphodipropionate.
  • the composition of a basic cleaner includes the surfactant or mixture of surfactants at about 0.1 percent to about 20.0 percentage by weight. This range of surfactant is for usage in a nondiluted product for household use. Thymolphthalein in the range of about 0.01 percent to about 1 percent by weight will give a broad range of blue color when varying intensity using an alkali system to adjust the pH of the composition.
  • U.S. 4,329,334 shows a homogeneous liquid anionic-amphoteric based antimicrobial conditioning shampoo which includes about 0.5 to 2.5 percent of the antimicrobial agent, l-imidazolyl-l-(4-chlorophenoxy)-3, 3-dimethylbutan-2, one, solubilized in an aqueous solution of critical amounts of a mixture of the following specific ingredients: about 10-40 percent by weight of an anionic sulfate or sulfonate surface active agent; about 0.1-7.5 percent by weight of an amphoteric surfactant selected from the group consisting of cocobetaine, cocosulfobetaine, cocoamidopropylbetaine, cocoamidopropylsulfobetaine or combinations thereof; a nonionic surface active agent selected from the group consisting of a tertiary amine oxide, a polyoxyethylene hexitan mono-higher fatty acid ester and mixtures thereof; and about 0.5-2 percent by weight of a lower
  • U.S. 3,654,165 teaches a cleaner-sanitizer for use on telephone instruments including a fast-acting, penetrative, quick-drying bacteriocidal detergent solution which leaves a safe, active residue of selected proportions of sodium lauryl sulfate, dimethyl sulfone, isopropanol and iodine in solution.
  • U.S. 4 793,988 describes a composition for disinfecting a surface, such as a public restroom facility or telephone. The composition and delivery of the composition provides for the placement of a thin layer of disinfectant including a dye. The dye disappears as the thin layer effects the germicidal activity of the disinfectant.
  • a sample of the germicidal composition was prepared with 400 mg of sodium dodecyl sulfate (SDS), 400 mg of octyl phenoxy polyethoxyethanol marketed as Triton X-100 and 100 mg of blue dye thymophthalein.
  • SDS sodium dodecyl sulfate
  • octyl phenoxy polyethoxyethanol marketed as Triton X-100
  • This composition was tested for germicide effectiveness against Herpes simplex virus type 2, Neisseria gonorrhaeae, Staphylococcus aureus, Escherichia coli 011K58, Shigela sonnei, Salmonella typhimurium and Candida albicans.
  • U.S. 4,975,217 describes germicidal compositions for direct application to human skin including an organic acid, e.g., malic acid, and an anionic surfactant, e.g., a sodium alpha-olefin sulfonate, as active ingredients, and can optionally include an alcohol, e.g., specially denatured ethyl alcohol, as an additional active ingredient.
  • an organic acid e.g., malic acid
  • an anionic surfactant e.g., a sodium alpha-olefin sulfonate
  • an alcohol e.g., specially denatured ethyl alcohol
  • Organic acids and anionic surfactants e.g., malic acid and a sodium alpha-olefin sulfonate surfactant, are used as active ingredients in germicidal products which are applied directly to the skin, such as hand-washing soaps, skin-care lotions, soapy-lotions, or wipes containing these materials.
  • the products can include an alcohol, such as. specially denatured ethyl alcohol, ethyl alcohol and isopropyl alcohol as an additional active ingredient.
  • These formulations in addition to killing viruses, also effecctively kill bacteria and yeasts.
  • the formulations have been found to kill a variety of microorganisms both in vitro experiments performed in test tubes and, even more importantly, in in vivo experiments performed on human hands. Moreover, notwithstanding their germicidal activity, the formulations have been found to be non-irritating to human skin.
  • U.S. 4,046,706 shows a composition for cleaning contact lenses comprising a poly(oxyethylene)-poly(oxypropylene) block copolymer having a molecular weight between 1900 and 15,500, a water solubility in excess of about 10 gms per 100 nl, a cloud point in 1 percent aqueous solutions above about 30 degrees C, and a foam height in excess of 30 mm; a microbial growth inhibitor; ethyl or isopropyl alcohol; an amphoteric surfactant and water.
  • U.S. 3,578,499 teaches a powder composition containing a gelling agent, a neutral diluent, a wetting agent and a dye or " coloring additive.
  • the powder gelling composition when added to water forms a gel.
  • Acid or alkaline materials are added for cleaning, biocidal agents for sanitizing or other materials to produce a desired effect.
  • the significant advantage of this method is the increased residence time and hence contact time between agents in the gel and the surface to be acted on.
  • a third component included in the gelling composition is a wetting agent exemplified by a linear alkyl benzene sulfonate type material wherein the alkyl group may include from about 12 to 14 carbon atoms.
  • the wetting agent should be desirably characterized as a anionic agent although it is recognized that nonionic surfactants may also be employed.
  • One wetting agent found useful herein is the commercially available sulfonate of dodecylbenzene.
  • U.S. 2,333,124 describes a method for sterilizing air laden with bacteria or other pathogenic organisms comprising contacting the air with a mixture of glycols in vapor form in proportions to provide about 1 gram of such glycols in vapor form to not more than about 5 to 7 million cubic centimeters of air.
  • U.S. 2,857,315 shows a stable anti-perspirant stick having a base comprising a sodium stearate-propylene glycol soap gel having an active anti-perspirant agent sodium zirconium lactate.
  • the sodium stearate-propylene glycol soap gel may contain alcohol in an amount not substantially greater than the propylene glycol by weight.
  • Various spray germicides for sanitizing such surfaces is typified by in U.S. 3,445,564.
  • U.S. 3,445,564 is directed to a method, compositions and articles for sanitizing public or communal facilities prior to individual use. The method consists of applying a thin layer of a rapidly drying liquid germicidal composition to a surface such as a toilet seat.
  • the rapidly drying germicidal compositions consist essentially of a lower eliphatic alcohol and at least about 5 percent of a volatizing agent therefor, such as acetone.
  • a volatizing agent such as acetone.
  • Isopropyl alcohol has excellent germicidal activity and sufficiently volatile to give a satisfactory drying rate when blended with suitable proportions of a volatizing agent.
  • the lower eliphatic alcohols are not sufficiently volatile to afford usefully short drying times for practical purposes in the method and articles of the Kirschner invention it was necessary to include a volatizing agent in the germicidal composition.
  • the proportion of volatizing agent to lower aliphatic alcohol in the rapidly drying germicidal compositions employed in the invention may vary widely depending upon a number of factors, which include among others, the volatility of the alcohol employed, the volatility of the volatilizing agent, the desired drying rate of the germicidal composition, the amount of germicidal agent applied to the surface to be treated and the method of application of the germicide, not to mention the prevailing conditions of temperature and relative humidity under which the product is to be employed.
  • U.S. 3,445,564 has germicidal activity against bacteria, fungi and other lower organisms, additional antibacterial, antifungal or other active ingredients may be incorporated to enhance the overall germicidal effectiveness. Suitable germicidal additives include the well known antibacterial quaternary ammonium compound. In essence, U.S. 3,445,564 teaches the use of isopropyl alcohol to kill a limited number of germs on a dry toilet seat with the addition of acetone to volatize an already highly volatile chemical to rapidly dry the toilet seat for use within 30 seconds.
  • U.S. 4,678,658 shows an aerosol spray for use in disinfecting a surface for personal use such as a public restroom facility or telephone.
  • the composition and delivery of the compositions provides for the placement of a spray of disinfectant which includes a dye that disappears as the spray effects the germicidal activity of the disinfectant.
  • the composition is also rapidly drying, so that the dye disappears as well as the disinfecting composition leaving the surface dry.
  • the spray is corrosive and environmentally unsafe.
  • 3,821,413 discloses a formulation of materials which permits an effective, uniform rate of evaporation of glycols from an air circulator device to reduce airborne bacteria in the surrounding atmosphere. It was observed that the relative amounts and identities of the components of the invention are critical to the attainment of the desired continuous evaporation of glycols over a prolonged period of time.
  • the composition of U.S. 3,821,413 is a single phase liquid composition especially adapted for volatilization at a substantially uniform rate from the air circulator device.
  • the composition includes three essential components (1) a glycol, (2) an organic polar coupling compound for maintaining the homogeneity prevents the glycol from separating from the mixture during evaporation of the mixture into the atmosphere and (3) an organic, relatively non-polar compound for forming hydrophobic micelles with the glycol molecules in the resulting mixture for reducing the affinity of the glycol to atmospheric moisture and thereby increasing the rate at which the glycol may be evaporated into the atmosphere.
  • the composition contains the glycol germicide. If desired, other suitable germicides or antiseptic agents can be added provided, however, that the glycol concentration of the composition does not fall below 5 percent by weight of the total mixture.
  • germicides include quaternary ammonium compounds, phanols, bisphenols, salicylanilides, carbanilides, formaldehyde and chloride.
  • the required glycol evaporation rate for attaining the desired air sanitizing performance depends on the satisfactory stability and uniform nature of the liquid composition during evaporation from the mixture. Accordingly, the compositions of the invention include from about 2 percent to about 40 percent by weight of an organic polar coupling compound for maintaining the homogeneity of the mixture to prevent the glycol from separating from the mixture during the evaporation process.
  • compositions of the invention include from about 5 percent to about 80 percent by weight of an organic, relatively non-polar compound for forming hydrophobic micelles surrounding the glycol molecules in the mixture for reducing the affinity of the glycol to atmospheric moisture and thereby increase the rate of evaporation of the glycol. Without this micelle formation, it was found that the glycol or mixture of glycols in the mixture cannot evaporate appreciably in an air circulator device containing a wick immersed in the liquid composition.
  • U.S. 3,806,593 is directed to an acne treatment medication applied to the skin for preventing the formation of acne or decreasing already established acne.
  • An important factor for the occurrence of acne is the presence of bacteria in the sebaceous glands in the skin. It is known that the bacteria in the sebaceous glands form esterases which hydrolyze the sebum fats to alcohols and free fatty acids.
  • the medicinal acne-preventing or acne-diminishing composition of U.S. 3,806,593 is based on the bacterial esterase activity in the sebaceous glands which together with the water already present in the skin can hydrolyze an ester having a good penetration capacity into the sebaceous glands to form one and preferably two antibacterially active components, viz. an acid and an alcohol, which are harmless to the skin.
  • the active compound in the composition is one or more esters chosen from the group consisting of ethyl lactate, isopropyl lactate and/or glycerol mono or dilactate.
  • the esters hydrolyze in the sebaceous glands due to the esterases present in the glands to form the corresponding acids and alcohols.
  • - Lactic acid and the lower alcohols and also glycerol to a certain extent exert a good antibacterialactivity when formed in situ in the sebaceous glands.
  • the esters are lipophilic and can thus penetrate into the said glands. Even if a beneficial action can be achieved by application of the ester or esters per se, it has been found to be suitable to apply the ester in the form of a solution in ethyls alcohol or isopropyl alcohol.
  • the alcohol prevents hydrolysis of the ester already in the composition, the alcohol moves the hydrolysis equilibrium towards ester formation.
  • the alcohol can also facilitate the penetration of the ester into the skin.
  • the composition may include a moisture-retaining agent such as a lower, suitably water-free polyol, viz. propylene glycol or glycerol.
  • a moisture-retaining agent such as a lower, suitably water-free polyol, viz. propylene glycol or glycerol.
  • the content of propylene glycol or glycerol in the composition according to the invention may be up to 25 percent, suitably not more than 10 percent by weight and preferably 1-5 percent. High levels of polyol tend to make the composition smeary upon application on the skin and should thus be avoided.
  • the preferred composition according to the invention consists of about 15 percent by weight of ethyl lactate, about 2 percent by weight of propylene glycol, the remainder being ethyl alcohol.
  • U.S. 3,806,593 relates to acne medication comprising esters that hydrolize in the sebaceous glands in combination with an alcohol to prevent hydrolysis of the esters as well facilitate the penetration of the ester into the skin, and propylene glycol or glycerol to prevent drying of the skin.
  • the preferred ration of the constituents is 15 percent to 83 percent to 2 percent respectively.
  • U.S. 4,664,909 discloses a stable, fast drying pituitous powder deodorant suspension in an alcohol media containing a minimal amount of water and a critical amount of the essential hydroxyethyl cellulose as the suspending agent.
  • the fast drying pituitous suspension of particulate material in an aqueous alcohol media contains hydroxyethyl cellulose at levels above its normal solubility limit by polyhydric.
  • U.S. 4,664,909 relates to stable pituitous suspensions of particulate material, preferably about 1-20 percent, uniformly suspended in alcohol/aqueous media containing a high alcohol content and a lower water content.
  • the alcohol media may be a lower monohydric alcohol selected from the group consisting of ethanol, ethanol, isopropanol and mixtures thereof.
  • polyhydric alcohols such as propylene glycol, butylene glycol and polyols thereof, and glycerin decreases the critical water level required in the hydroxyethyl cellulose-containing alcohol media.
  • powders can be suspended in alcoholic/aqueous media containing a high alcohol content and a lower water content by using the water soluble polymer hydroxyethyl cellulose at critical levels above its ethanol solubility range which may be broadened by specified polyhydric alcohols.
  • This polymer is unique in its property to form stable suspensions.
  • polyhydric alcohols can be partially substituted for the monohydric alcohol, not to exceed the monohydric alcohol content.
  • the monohydric alcohol content such as ethanol, must exceed the upper solubility level for the water soluble polymer hydroxyethyl cellulose in ethanolor other lower alkanol.
  • the reported upper solubility level of this water soluble polymer in ethanol is 70 percent. Below this level and within normal soluble use ranges, a uniformly viscous liquid is obtained which pours evenly. Although, it appears aesthetically desirable, it will not support suspended powder and segregation occurs. However, at ethanol concentrations above its solubility range, the polymer becomes less soluble and forms the desired pititious type liquid.
  • the monchydric alcohol constitutes about 55-85 percent; and the water content may be as low as 5 percent if at least 10 percent polyhydric alcohol is also present in the suspension.
  • the combined water and polyhydric alcohol content is at least 15 percent and may be up to about 25 percent.
  • U.S. 4,664,909 teaches a fast-drying deodorant comprising a critical amount of hydroxyethyl eellose as the deodorant to encapsulate or isolate bacteria to prevent growth of the bacteria, suspended in a solution of monohydric alcohol to provide the fast drying characteristics and polyhydric alcohol to improve the overall soluability of the solution to allow the use of increased levels of monohydric alcohol.
  • the relative proportions of themonohydric alcohol, water and polyhydric alcohol are driven or determined by the desired solubility and therefore are interdependent.
  • U.S. 3,821,413 teaches a disinfectant consisting of propylene glycol to stabilize the composition and retard evaporation. This disinfectant is toxic, corrosive and non-biodegradable.
  • U.S. 3,966,902 disclosed various polymer complex carriers such as propylene glycol for use with an active ingredient such as a disinfectant or fragrance.
  • U.S. 4,690,779 refers to the use of propylene glycol in combination with alcohol and fragrances. This composition is both toxic and non-biodegradable.
  • U.S. 4,209,500 teaches a composition suitable for use in aerosol sprays including an anhydrous alcohol and fragrance or perfume. This composition is corrosive, non-biodegradable and non-evaporative.
  • Disinfectants today should be non-toxic and biodegradable and capable of killing or inactivating both pathogenic organisms. Further, such disinfectants should be chemically compatible with the numerous surfaces found in modern healthcare facilities.
  • the instant invention is directed to an environmentally safe surface disinfectant capable of killing anaerobic and aerobic bacteria, viruses including the HIV virus, mildew, mold and fungus.
  • the principal active anti-microbial, anti-viral ingredients of the invention are selected from a group of monohydric alcohols and polyhydric alcohols.
  • alcohols have had limited use outside the laboratory due to various undesirable characteristics of alcohol.
  • alcohol has very limited application as a widely used disinfectant because alcohol is unable to penetrate protein rich material, evaporates quickly, has limited stability and shelf life, has a pungent odor and tends to form a glaze on hard surfaces possibly hiding or covering visible contamination.
  • the instant invention has evolved from an extensive development program involving the unexpected formulation of certain chemicals to reduce or inhibit those undesirable features of alcohol and to make alcohol safe and effective for use outside the laboratory.
  • the present invention relates to a non-toxic hypocompatible biodegradable surface disinfectant for application to inanimate surfaces to kill a wide range of pathogenic organisms.
  • the surface disinfectant comprises a composition including an anionic, nonionic or cationic surfactant or mixture thereof, a monohydric alcohol and a polyhydric alcohol.
  • the anionic surfactants may be selected from the group consisting of petroleum sulfonates, such as sodium dodecylbenzene sulfonate, alcohol sulfates such as sodium lauryl sulfate and ethoxylated higher fatty alcohol sulfates such as sodium lauryl ether sulfate and the like.
  • the nonionic surfactant may be selected from the group consisting of primary alcohol ethoxylates, secondary alcohol ethoxylates, alkyl phenol ethoxylates, alkanolamides and the like.
  • the cationic surfactant may be selected from the group consisting of cetypyridinium, methylbenzethonium chloride, dodecylamine, hexadecylamine, hexadecylamine hydrochloride, dodecylaniline, oleylmethylamine, ethylenediethylamine, methyl sulfate, oleylbenzylaminoethylenediethylamine hydrochloride, sulfate of lauryl pyridinium, octadecyl- me hylenepyridinium acetate, methyl sulfate of dimethyloctadecylsulfonium, betaine compound of diethyl- aminoacetic acid and octadecylchloromethyl ether and the like.
  • the monohydric alcohol is selected from the group consisting of isopropyl, methyl, ethyl, n-propyl, n-butyl, tert-butyl alcohol or allyl alcohol and/or mixtures thereof.
  • the polyhydric alcohol is selected from the group consisting of propylene glycol; 1,3 propanediol; 1,2 butanediol, PEG 400; glycerol or.1,4 butanediol and/or mixtures thereof.
  • the proportion by weight is such that the polyhydric alcohol reduces the surface glaze formed by the monohydric alcohol and surface tension formed by water or water-based body fluids enabling the germicide to kill the pathogenic organisms and act equally effective on a patient or inanimate surface without deleterious effect to either.
  • the monohydric alcohol provides the primary disinfecting or killing effect on the pathogenic organisms; while, the polyhydric alcohol lowers the flash point of the composition and soothes the skin.
  • the polyhydric alcohol also slows the rate of evaporation, reduces or eliminates the intersurface glazing effect of monohydric alcohol and homogenizes the interactive ingredients.
  • the relative proportions by weight of interactive ingredients chemically reduces the tensile strength of the surface liquids on the surface permitting the surface disinfectant effect to act directly on the pathogenic organisms.
  • the non-toxic hypocompatible biodegradable surface disinfectant in liquid form may be dispensed in various delivery systems including spray, foam, pour and squirt for a aerosol or non-aerosol product.
  • Alternate systems may include a towelette or an absorbent wipe containing the product in an airtight enveloping material such as sealed foil or other wrapping material could be used for a single application.
  • the invention accordingly comprises the features of construction, combination of elements, and arrangement of parts which will be exemplified in the construction hereinafter set forth, and the scope of the invention will be indicated in the claims.
  • the present invention relates to a non-toxic hypocompatible surface disinfectant for application on hard surfaces such as floors, restrooms or tables effective against a wide range of pathogenic organisms such as bacteria including staphylococcus aureus, pseudomonas aeruginosa and salmonella coleraesuis and viruses including HIV-I, HIV-II, tuberculosis, polio and herpes simplex type 2 as well as fungi (trichophyton mentagrophytus), mold, mildew and spores through alternate delivery means.
  • pathogenic organisms such as bacteria including staphylococcus aureus, pseudomonas aeruginosa and salmonella coleraesuis and viruses including HIV-I, HIV-II, tuberculosis, polio and herpes simplex type 2 as well as fungi (trichophyton mentagrophytus), mold, mildew and spores through alternate delivery means.
  • the surface disinfectant comprises a non-toxic hypocompatible biodegradable composition of selected surfactants, selected monohydric alcohols, selected polyhydric alcohols and inert ingredients combined in relative proportions by weight to disinfect various surfaces through direct application without deleterious effect to the surfaces to be disinfected.
  • the surfactant may be anionic, nonionic or cationic or mixtures thereof.
  • the anionic surfactant may be selected from the group consisting of petroleum sulfonates, such as sodium dodecylbenzene sulfonate, alcohol sulfates such as sodium lauryl sulfate and ethoxylated higher fatty alcohol sulfates such as sodium lauryl ether sulfate and the like.
  • the nonionic may be selected from the group consisting of primary alcohol ethoxylates, secondary alcohol ethoxylates, alkyl phenol ethoxylates, alkanolamides and the like.
  • the cationic may be selected from the group consisting of cetylpyridium, methylbenzethinium, chloride, dodecylamine, hexadecylamine, hexadecylamine hydrochloride, dodecyl aniline, oleyl methylamine ethylene diethylamine methyl sulfate, oleyl benzylamino ethylene diethyamine hydrochloride, sulfate of lauryl pyridinium, octudecyl methyleno pyridinium acetate, methyl sulfate of dimethyloctadecyl sulfonium, betaine compound of diethyl aminoacetic acid and octadecyl chloromethyl ether and the like.
  • the monohydric alcohol is selected from the group consisting of isopropyl, methyl, ethyl, n-propyl, n-butyl, tert-butyl or allyl or mixtures thereof.
  • the polyhydric alcohol is selected from the group consisting of propylene glycol; 1,3 propanediol; 1,2 butanediol, PEG 400; glycerol or 1,4 butanediol or mixtures thereof.
  • non-toxic refers to the requirements of the LD 50 Oral Toxicity Test; that is, non-toxic, non-poison, to rate at 50 times the lethal dose.
  • biodegradable refers to decomposition in the presence of 25 percent organic material within 90 days at 69 degrees F (Standard Temperature) with moisture content of 100 parts per million.
  • hypocompatible shall mean no material degradation efforts associated with surfaces to include, for example, discoloration, corrosion, cracking, crazing and embrittlement.
  • the specific monohydric alcohols and polyhydric alcohols and relative ratios thereof optimize the particular characteristics of solubility, specific gravity, conductivity, pH, flash point, boiling point and evaporation essential to the effective use of the instant germicide against the challenge as defined herein on pathogens as described herein with a nontoxic effect as defined herein on patients, and with a hypocompatible effect as defined herein on the surfaces described herein.
  • the presence of the polyhydric alcohol raises the boiling point of the surface disinfectant slowing the rate of evaporation of the surface disinfectant.
  • the polyhydric alcohol prevents the tendency of monohydric alcohol to form a glaze on the target surface that masks the pathogenic organisms and breaks the barrier formed by surface tension of water and water-based body fluids enabling the surface disinfectant to act on the pathogens more rapidly.
  • the polyhydric alcohol serves as an emulsifier to assure that the composition remains homogenized during storage and use.
  • the polyhydric alcohol reduces the harmful effects of monohydric alcohol if swallowed or sprayed into the eyes or on mucus membranes as well as soothing the skin upon contact. Since the polyhydric alcohol reduces toxicity to human cells the need to dilute the surface disinfectant has been eliminated. Polyhydric alcohol also acts as a secondary disinfectant useful to disinfect air. In the preferred percentage used, tests indicate that the polyhydric alcohol increases the overall effectiveness of the germicide against most viruses, mold and mildew. Since the surface disinfectant was developed for use on a wide variety of surfaces and dispensed from a number of dispensing modes or means of dispersant materials the measure of chemical resistance is important to permit broad use and application. To be effective, the surface disinfectant must be hypocompatable with CPVC, Epoxy, Polypropylene, PVC, Cyolac
  • the composition should have a pH of between about 7 and 5, virtually evaporate before about 6 and 20 minutes to have an effective kill time of about 8 to 12 minutes and prevent surface residue, a specific gravity of about .85, viscosity below 4 and relatively no conductivity.
  • the effective proportional relationship of the ingredients by weight for the surfactant as described herein is about between 0.005 and 1.0, for the monohydric alcohol as described herein is between about 65 percent to 75 percent and for the polyhydric alcohol as described herein is between about 4 percent and 16 percent.
  • the most preferred proportional relationship of the active ingredients by weight is about 70 percent for the monohydric alcohol and between 8 to 12 percent for the polyhydric alcohol.
  • the preferable amount of polyhydric alcohol is 6 to 14 percent by weight. Less than 4 percent of polyhydric alcohol by weight does not provide adequate kill and exhibits an excessive alkaline pH; while, more than 16 percent of polyhydric alcohol by weight leaves a residue to attract and harbor pathogens.
  • This surface disinfectant is capable of absorbing and lifting 25 percent (by weight) of organic matter relative to the weight of the surface disinfectant.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne un désinfectant de surfaces biodégradable, hypocompatible et non toxique, efficace pour lutter contre une large gamme d'organismes pathogènes, pouvant absorber des matières organiques en les décollant des surfaces. Ce désinfectant est composé de constituants interactifs comprenant un tensioactif, un alcool monovalent proportionné en poids de telle façon que l'alcool polyvalent réduise l'enduit de la surface formé par l'alcool monovalent et la tension superficielle formée par l'eau ou les fluides biologiques à base d'eau, permettant au désinfectant de surfaces de tuer les organismes pathogènes sans qu'il y ait d'effets nocifs au niveau de la surface.
PCT/US1993/001695 1992-03-02 1993-03-02 Desinfectant de surfaces biodegradable WO1993017723A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37782/93A AU3778293A (en) 1992-03-02 1993-03-02 Biodegradable surface disinfectant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84412592A 1992-03-02 1992-03-02
US844,125 1992-03-02

Publications (1)

Publication Number Publication Date
WO1993017723A1 true WO1993017723A1 (fr) 1993-09-16

Family

ID=25291885

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/001695 WO1993017723A1 (fr) 1992-03-02 1993-03-02 Desinfectant de surfaces biodegradable

Country Status (1)

Country Link
WO (1) WO1993017723A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025426A1 (fr) * 1993-04-28 1994-11-10 Alcon Laboratories, Inc. Diamines utiles comme agents antimicrobiens et leur utilisation dans des compositions ophtalmiques
WO1999027784A1 (fr) * 1997-11-28 1999-06-10 Reckitt Benckiser, Inc. Compositions bactericides aqueuses basees sur des alkylbenzenesulfonates et du n-propanol
WO2000027438A1 (fr) * 1998-11-06 2000-05-18 Universite De Montreal Solutions bactericides et non bactericides servant a eliminer des films biologiques
WO2022069715A1 (fr) 2020-10-02 2022-04-07 Helm Ag Chlorures de trialkyl sulfonium utilisés comme fongicides
US20220166565A1 (en) * 2017-04-28 2022-05-26 Panasonic Intellectual Property Corporation Of America Measurement apparatus and measurement method
CN116709915A (zh) * 2020-10-02 2023-09-05 汉姆股份公司 作为杀真菌剂的三烷基氯化锍
US12258540B2 (en) 2017-10-30 2025-03-25 Takeda Pharmaceutical Company Limited Environmentally compatible detergents for inactivation of lipid-enveloped viruses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511486A (en) * 1981-11-02 1985-04-16 Richardson-Vicks Inc. Method of cleaning dentures using aerated foams

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511486A (en) * 1981-11-02 1985-04-16 Richardson-Vicks Inc. Method of cleaning dentures using aerated foams

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025426A1 (fr) * 1993-04-28 1994-11-10 Alcon Laboratories, Inc. Diamines utiles comme agents antimicrobiens et leur utilisation dans des compositions ophtalmiques
US5900213A (en) * 1993-04-28 1999-05-04 Alcon Laboratories, Inc. Use of diamines to disinfect and clean contact lenses and preserve ophthalmic compositions
WO1999027784A1 (fr) * 1997-11-28 1999-06-10 Reckitt Benckiser, Inc. Compositions bactericides aqueuses basees sur des alkylbenzenesulfonates et du n-propanol
US6083994A (en) * 1997-11-28 2000-07-04 Reckitt Benckiser Inc. Aqueous bactericidal compositions based on synergistic combination of linear alkylbenzenesulfonates and n-propanol
AU747739B2 (en) * 1997-11-28 2002-05-23 Reckitt Benckiser Inc. Aqueous bactericidal compositions based on alkylbenzenesulfonates and N-propanol
WO2000027438A1 (fr) * 1998-11-06 2000-05-18 Universite De Montreal Solutions bactericides et non bactericides servant a eliminer des films biologiques
US20220166565A1 (en) * 2017-04-28 2022-05-26 Panasonic Intellectual Property Corporation Of America Measurement apparatus and measurement method
US11711178B2 (en) * 2017-04-28 2023-07-25 Panasonic Intellectual Property Corporation Of America Measurement apparatus and measurement method
US12258540B2 (en) 2017-10-30 2025-03-25 Takeda Pharmaceutical Company Limited Environmentally compatible detergents for inactivation of lipid-enveloped viruses
WO2022069715A1 (fr) 2020-10-02 2022-04-07 Helm Ag Chlorures de trialkyl sulfonium utilisés comme fongicides
WO2022069714A1 (fr) 2020-10-02 2022-04-07 Helm Ag Sels de trialkyl sulfonium
CN116709915A (zh) * 2020-10-02 2023-09-05 汉姆股份公司 作为杀真菌剂的三烷基氯化锍

Similar Documents

Publication Publication Date Title
AU667930B2 (en) Nonaqueous cold sterilant
CA2166810C (fr) Germicide hypocompatible, biodegradable, non toxique
US5403587A (en) Disinfectant and sanitizing compositions based on essential oils
JP5587094B2 (ja) マイコバクテリアを制御するための、芳香族アルコールとグリセロールエーテルの混合液に基づく相乗的製剤
EP1406494A2 (fr) Composition bactericide comprenant de la polylysin et d'huiles naturelles
US20070281039A1 (en) Essential oils based disinfecting compositions having tuberculocidal and fungicidal efficacies
CA1337329C (fr) Desinfectant biodegradable
US5985929A (en) Cold chemical sterilant
US5637307A (en) Method of immersion sterilization and organic cold chemical sterilant
US11871749B2 (en) Alcohol-free hydrogen peroxide disinfectant compositions and methods of use thereof
EP0609106B1 (fr) Une composition de glutaraldehyde
WO1993017723A1 (fr) Desinfectant de surfaces biodegradable
CN111184658A (zh) 一种手部消毒液及其制备方法
WO2022038630A1 (fr) Composition de nettoyage de surface et son utilisation
WO1993016737A1 (fr) Germicide biodegradable
US5674829A (en) Stable aqueous glutaraldehyde solutions containing sodium acetate and a nonionic detergent
EP3764975B1 (fr) Composition de désinfectant
US20100249247A1 (en) Antimicrobial compositions
TR202021525A1 (tr) Böceklere karşi etki̇li̇ anti̇mi̇krobi̇yal temi̇zleme ürünü

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU BG BR CA DE DK GB HU JP KP KR NO RO RU SE

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载