WO1993003841A1 - Ion exchanger, production thereof, and process for separating biopolymer by using same - Google Patents
Ion exchanger, production thereof, and process for separating biopolymer by using same Download PDFInfo
- Publication number
- WO1993003841A1 WO1993003841A1 PCT/JP1992/001061 JP9201061W WO9303841A1 WO 1993003841 A1 WO1993003841 A1 WO 1993003841A1 JP 9201061 W JP9201061 W JP 9201061W WO 9303841 A1 WO9303841 A1 WO 9303841A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cross
- linked
- ion exchanger
- production
- pores
- Prior art date
Links
- 229920001222 biopolymer Polymers 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000011148 porous material Substances 0.000 abstract 3
- 239000002131 composite material Substances 0.000 abstract 2
- 239000000499 gel Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000011347 resin Substances 0.000 abstract 2
- 229920005989 resin Polymers 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 1
- 238000003795 desorption Methods 0.000 abstract 1
- 238000005342 ion exchange Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/16—Organic material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
An ion exchanger comprising a composite having a degree of swelling in water of 2 to 7 ml/g of resin, said composite being prepared by holding a cross-linked gel, which comprises a hydrophilic natural macromolecule having a three-dimensional cross-linked network structure and has ion-exchange groups, in the pores of a porous particle of a hydrophilic cross-linked copolymer having pores with a diameter of 0.01 to less than 1 νm, a pore volume of 30 to 70 % of the resin volume and preferably a particle diameter of 5 to 500 νm; a process for the production thereof; and a process for separating biopolymers such as proteins by using the ion exchanger. This exchanger undergoes little volume change, serves to remedy the shortcomings of conventional cross-linked gels in passing various liquids, and has merits of being free from nonspecific adsorption and having high adsoprtion and desorption rates in the separation of biopolymers such as proteins.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21229691 | 1991-08-23 | ||
| JP3/212296 | 1991-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1993003841A1 true WO1993003841A1 (en) | 1993-03-04 |
Family
ID=16620234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP1992/001061 WO1993003841A1 (en) | 1991-08-23 | 1992-08-24 | Ion exchanger, production thereof, and process for separating biopolymer by using same |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO1993003841A1 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013011632A (en) * | 2012-10-19 | 2013-01-17 | Sekisui Chem Co Ltd | Measurement method of hemoglobin a1c |
| JP2013515258A (en) * | 2009-12-22 | 2013-05-02 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | Method for dry-packing chromatography columns |
| JP2017125796A (en) * | 2016-01-15 | 2017-07-20 | 日立化成株式会社 | Separation material and column |
| JP2017125814A (en) * | 2016-01-15 | 2017-07-20 | 日立化成株式会社 | Separation material and column |
| JP2019177509A (en) * | 2018-03-30 | 2019-10-17 | 株式会社リコー | Hydrogel structure, production method and organ model |
| JP2021069991A (en) * | 2019-10-31 | 2021-05-06 | 昭和電工株式会社 | Method for producing filler for glycosylated hemoglobin analysis column |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01254247A (en) * | 1988-04-01 | 1989-10-11 | Mitsubishi Kasei Corp | Composite separation agent and its manufacturing method |
-
1992
- 1992-08-24 WO PCT/JP1992/001061 patent/WO1993003841A1/en active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01254247A (en) * | 1988-04-01 | 1989-10-11 | Mitsubishi Kasei Corp | Composite separation agent and its manufacturing method |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013515258A (en) * | 2009-12-22 | 2013-05-02 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | Method for dry-packing chromatography columns |
| US9958421B2 (en) | 2009-12-22 | 2018-05-01 | Ge Healthcare Bioprocess R&D Ab | Method for dry packing chromatography columns |
| JP2013011632A (en) * | 2012-10-19 | 2013-01-17 | Sekisui Chem Co Ltd | Measurement method of hemoglobin a1c |
| JP2017125796A (en) * | 2016-01-15 | 2017-07-20 | 日立化成株式会社 | Separation material and column |
| JP2017125814A (en) * | 2016-01-15 | 2017-07-20 | 日立化成株式会社 | Separation material and column |
| JP2019177509A (en) * | 2018-03-30 | 2019-10-17 | 株式会社リコー | Hydrogel structure, production method and organ model |
| JP2021069991A (en) * | 2019-10-31 | 2021-05-06 | 昭和電工株式会社 | Method for producing filler for glycosylated hemoglobin analysis column |
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