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WO1993002700A1 - Utilisation du collagene dans la prophylaxie d'infections herpetiques labiales - Google Patents

Utilisation du collagene dans la prophylaxie d'infections herpetiques labiales Download PDF

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Publication number
WO1993002700A1
WO1993002700A1 PCT/DE1992/000631 DE9200631W WO9302700A1 WO 1993002700 A1 WO1993002700 A1 WO 1993002700A1 DE 9200631 W DE9200631 W DE 9200631W WO 9302700 A1 WO9302700 A1 WO 9302700A1
Authority
WO
WIPO (PCT)
Prior art keywords
collagen
prophylaxis
skin
herpes labialis
infections
Prior art date
Application number
PCT/DE1992/000631
Other languages
German (de)
English (en)
Inventor
Edwin Klaus
Original Assignee
Edwin Klaus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edwin Klaus filed Critical Edwin Klaus
Publication of WO1993002700A1 publication Critical patent/WO1993002700A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]

Definitions

  • herpes in humans An example of this is blister lichen, herpes simplex, a virus-related, harmless skin condition in which grouped, millet-sized blisters, for example, appear on the mouth (herpes labialis), which dry up after a few days. It shows up in febrile illnesses (especially with pneumonia or kidney infections or malaria), after heavy tanning and in women during menstruation.
  • Collagens are long-fiber, linear-colloidal, high-molecular Skieroproteins of the extracellular matrix, which occur in connective tissues (e.g. skin, cartilage, tendons, ligaments and blood vessels), in the protein-containing basic substance of the bone (ossein) and in dentin (dentin) together with proteoglycans. With a share of 25 to 30%, they are the most common animal proteins in terms of quantity.
  • the basic structural unit of collagen, tropo-collagen (MW approx. 300,000), consists of three polypeptide chains in the form of special left-handed helices, which - in accordance with a technique also known in rope making - are in turn turned to the right (triple helix).
  • the tropo-collagen molecule is a "rope" of 280 nm in length with a diameter of 1.4 nm; the fibrils measure a cross-section of 200-500 nm (see Römpps Chemielexikon, Vol. 3, p. 2297, 1990).
  • Modified collagen is being tested in medicine as a temporary skin replacement, as a replacement for cornea and vitreous fluid in the eye, as a replacement for tendons, tendon sheaths, hollow organs and veins, as a blood plasma substitute and in wound healing (EP-B 52288, .TP-A-52 -076416).
  • Collagen sponge is used as a hemostatic agent.
  • Medicines containing collagen are used to improve expandable skin deformations, such as those associated with scars, skin loss caused by different causes, and age-related skin folds. These collagen-containing medicines are injected under the skin to be filled in and for this reason usually contain a local anesthetic.
  • collagen is used for the manufacture of a medicament for the prophylaxis of herpes labialis infections.
  • the collagen used is insoluble collagen, which can be obtained from calf or bovine skin, for example; however, collagen from bovine skin is preferred.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

On utilise le collagène pour préparer un médicament prophylactique d'infections herpétiques labiales. On prépare de préférence une suspension injectable qui contient du collagène et le cas échéant un anesthésique local. La suspension injectable est administrée par injection dans la zone de transition entre la peau et la muqueuse dans la région des lèvres.
PCT/DE1992/000631 1991-07-31 1992-07-28 Utilisation du collagene dans la prophylaxie d'infections herpetiques labiales WO1993002700A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4125393.0 1991-07-31
DE19914125393 DE4125393A1 (de) 1991-07-31 1991-07-31 Verwendung von kollagen zur prophylaxe von herpes labialis-infektionen

Publications (1)

Publication Number Publication Date
WO1993002700A1 true WO1993002700A1 (fr) 1993-02-18

Family

ID=6437430

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1992/000631 WO1993002700A1 (fr) 1991-07-31 1992-07-28 Utilisation du collagene dans la prophylaxie d'infections herpetiques labiales

Country Status (2)

Country Link
DE (1) DE4125393A1 (fr)
WO (1) WO1993002700A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE701570A (fr) * 1963-12-12 1968-01-19

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE701570A (fr) * 1963-12-12 1968-01-19

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIOLOGICAL ABSTRACTS vol. 68, no. 9 , 1979, Philadelphia, PA, US; abstract no. 52353, TENNICAN ,PATRICK O. ET AL. 'THE DIVERSE EFFECTS OF TOPICAL AND SYSTEMIC ADMINISTRATION OF ZINC ON THE VIRULENCE OF HERPES SIMPLEX GENITALIS.' Seite 5243 ; *

Also Published As

Publication number Publication date
DE4125393A1 (de) 1993-02-04

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