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WO1987005703A1 - Anticorps antiparatypiques, leur utilisation pour la detection et le traitement de maladies d'auto-immunite - Google Patents

Anticorps antiparatypiques, leur utilisation pour la detection et le traitement de maladies d'auto-immunite Download PDF

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Publication number
WO1987005703A1
WO1987005703A1 PCT/EP1987/000149 EP8700149W WO8705703A1 WO 1987005703 A1 WO1987005703 A1 WO 1987005703A1 EP 8700149 W EP8700149 W EP 8700149W WO 8705703 A1 WO8705703 A1 WO 8705703A1
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
autoimmune
diseases
antibody
thyroid
Prior art date
Application number
PCT/EP1987/000149
Other languages
German (de)
English (en)
Inventor
Klaus-Henning Usadel
Josef Volker Teuber
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of WO1987005703A1 publication Critical patent/WO1987005703A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Definitions

  • Antiparatypical antibodies its use in the detection and treatment of autoimmune diseases.
  • the physiological importance of idiotypic-antiidiotypic or paratypical-antiparatypic antibodies lies in their functional property of maintaining the immune balance.
  • the termination of an antibody response or cellular reactions with specific receptors against an antigen is mediated by the anti-response of anti-idiotypic antibodies which are directed against the antigen-specific antibodies or the antigen-specific receptors of these lymphocytes.
  • the presence of an anti-response with highly selective properties towards the antigen-induced antibody is necessary.
  • the balanced interaction of different antibodies may therefore protect our organism from the development of autoagressive diseases.
  • autoimmune diseases are essentially of the following forms: autoimmune thyroid diseases, type I diabetes mellitus, myasthenia gravis, Crohn's disease, ulcerative colitis, autoimmune hepatitis, autoimmune diseases of the hemopoietic system, uveitis, immune vasculitis, autoimmune nephropathy disorders and other generalized autoimmune diseases Connective tissue diseases.
  • the autoimmune thyroid diseases are in particular the following two forms:
  • the detection method according to the invention is based on the surprising finding that antibodies can be obtained which have such a high selectivity that a detection method can be made available by which the prognosis of the treatment with regard to the duration and dose of therapy and the expectation of remission in thyroid diseases also Use of thyrostatics, is calculable.
  • Solid carriers are e.g. B. starch, lactose, mannitol, methyl cellulose, talc, highly disperse silica, higher molecular weight fatty acids (such as stearic acid), gelatin, agar, calcium phosphate, magnesium stearate, animal and vegetable fats or solid high molecular weight polymers (such as polyethylene glycols).
  • Preparations suitable for oral administration can, if desired, contain flavorings and sweeteners.
  • the monoclonal antibodies provoked in this way were expanded in the same way to an ELISA system, which allows reliable detection of different TSH receptor autoantibody specificities, both qualitatively and quantitatively.
  • an antibody can be produced experimentally by sensitization in animals, which, analogous to the preliminary experiments on the TSH receptor antibody and antiparatypical antibodies by antiparatypical-paratypical binding, has ophthalmopathy-antigen specificity.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rehabilitation Therapy (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

On emploie à des fins de diagnostic pour la détermination spécifique des maladies d'auto-immunité, en particulier de la thyropathie auto-immunitaire, des anticorps antiparatypiques. De plus, lesdits anticorps antiparatypiques sont utilisés, pour le traitement de maladies d'auto-immunité, contre des cellules auto-réactives et des auto-anticorps pertinents.
PCT/EP1987/000149 1986-03-19 1987-03-13 Anticorps antiparatypiques, leur utilisation pour la detection et le traitement de maladies d'auto-immunite WO1987005703A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863609271 DE3609271A1 (de) 1986-03-19 1986-03-19 Verfahren und reagenz zum nachweis von autoimmunerkrankungen, arzneimittel zur behandlung von autoimmunerkrankungen sowie hierzu geeignete antiparatypische antikoerper
DEP3609271.1 1986-03-19

Publications (1)

Publication Number Publication Date
WO1987005703A1 true WO1987005703A1 (fr) 1987-09-24

Family

ID=6296775

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1987/000149 WO1987005703A1 (fr) 1986-03-19 1987-03-13 Anticorps antiparatypiques, leur utilisation pour la detection et le traitement de maladies d'auto-immunite

Country Status (5)

Country Link
EP (1) EP0263135A1 (fr)
JP (1) JPS63502928A (fr)
AU (1) AU7160887A (fr)
DE (2) DE3609271A1 (fr)
WO (1) WO1987005703A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0325847A1 (fr) * 1987-11-30 1989-08-02 Idec Pharmaceuticals Corporation Procédé pour la sélection d'anticorps anti-idiotypiques, et leur utilisation pour le diagnostic, la surveillance, et le traitement de maladie
WO1991009121A2 (fr) 1989-12-14 1991-06-27 Henning Berlin Gmbh Chemie- Und Pharmawerk Polypeptides possedant de recepteurs actifs de thyrotropine, sequences d'acide nucleique codant pour ces recepteurs et polypetides, et applications de ces polypeptides
WO1991010735A3 (fr) * 1990-01-15 1991-10-03 Inst Nat Sante Rech Med Recepteur humain de la tsh. sequence codant pour ce recepteur
WO1991018628A1 (fr) * 1990-06-08 1991-12-12 Symbicom Aktiebolag Therapie et prophylaxie de maladies auto-immunes
WO1996012189A3 (fr) * 1994-10-07 1996-04-25 Cedars Sini Medical Ct PROCEDES DE DEPISTAGE DE LA RECTOCOLITE HEMORRAGIQUE ET DE LA MALADIE DE CROHN PAR DETECTION DE L'AUTOANTICORPS VH3-15 ET DE pANCA

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007058A1 (fr) * 1987-03-16 1988-09-22 Biosolutions Pty. Ltd. Anticorps antiparatopique servant d'immunogene

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0113431A2 (fr) * 1982-12-03 1984-07-18 Yeshiva University Anticorps monoclonaux, réactifs avec des idiotypes communs aux anticorps humains de ADN native provenant de patients atteints de lupus érythémateux systémique
EP0133540A1 (fr) * 1983-08-03 1985-02-27 E.I. Du Pont De Nemours And Company Déterminations d'un récepteur employant des anticorps marqués monoclonaux et anti-idiotypiques
EP0139389A1 (fr) * 1983-08-24 1985-05-02 Synbiotics Corporation Réactifs contenant des anticorps monoclonaux et anti-idiotypiques et immunoessais les employant
WO1986001222A1 (fr) * 1984-08-06 1986-02-27 Centre National De La Recherche Scientifique (Cnrs Nouvelles cellules hybrides secretant des anticorps anti-idiotypiques, nouveaux anticorps monoclonaux secretes par lesdites cellules hybrides, leur preparation et leur application
WO1986001539A1 (fr) * 1984-08-27 1986-03-13 The Trustees Of Columbia University In The City Of Procede de production d'anticorps monoclonaux anti-idiotypiques
EP0176355A2 (fr) * 1984-09-25 1986-04-02 Immunomedics, Inc. Essai immunologique indépendant des antigènes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0113431A2 (fr) * 1982-12-03 1984-07-18 Yeshiva University Anticorps monoclonaux, réactifs avec des idiotypes communs aux anticorps humains de ADN native provenant de patients atteints de lupus érythémateux systémique
EP0133540A1 (fr) * 1983-08-03 1985-02-27 E.I. Du Pont De Nemours And Company Déterminations d'un récepteur employant des anticorps marqués monoclonaux et anti-idiotypiques
EP0139389A1 (fr) * 1983-08-24 1985-05-02 Synbiotics Corporation Réactifs contenant des anticorps monoclonaux et anti-idiotypiques et immunoessais les employant
WO1986001222A1 (fr) * 1984-08-06 1986-02-27 Centre National De La Recherche Scientifique (Cnrs Nouvelles cellules hybrides secretant des anticorps anti-idiotypiques, nouveaux anticorps monoclonaux secretes par lesdites cellules hybrides, leur preparation et leur application
WO1986001539A1 (fr) * 1984-08-27 1986-03-13 The Trustees Of Columbia University In The City Of Procede de production d'anticorps monoclonaux anti-idiotypiques
EP0176355A2 (fr) * 1984-09-25 1986-04-02 Immunomedics, Inc. Essai immunologique indépendant des antigènes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Biological Abstracts, Band 76, Nr. 5, Mai 1983, (Philadelphia, PA., US), M. ZANETTI et al.: "Anti-Idiotypic Immunity and Autoimmunity: 2. Idiotypic Determinants of Autoimmunity: 2. Idiotypic Determinants of Autoantibodies and Lymphocytes in Spontaneous and Experimentally Induced Autoimmune Thyroiditis", siehe seite 3703, Zusammenfassung 34125, & Cell. Immunol. 75(2): 292-299, 1983 *
CHEMICAL ABSTRACTS, Band 104, Nr. 15, 14. April 1986, (Columbus, Ohio, US), N.R. FARID: "Anti-Thyrotropin-Anti-Idiotypes as Probes for Thyrotropin Receptor Structure and Function", siehe seite 80, Zusammenfassung 123173g, & Ucla Symp. Mol. Cell. Biol., New Ser. 1985, 27(Monoclonal Antibodies Cancer Ther.), 299-316 *
The Journal of Immunology, Band 133, Nr. 5, November 1984, The American Association of Immunologists, (Baltimore, Maryland, US), M. LAURIE PHILIPPS et al.: "Idiotypic Analysis of Anti-I-A Monoclonal Antibodies", pages 2587-2594 siehe den ganzen artikel *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0325847A1 (fr) * 1987-11-30 1989-08-02 Idec Pharmaceuticals Corporation Procédé pour la sélection d'anticorps anti-idiotypiques, et leur utilisation pour le diagnostic, la surveillance, et le traitement de maladie
WO1991009121A2 (fr) 1989-12-14 1991-06-27 Henning Berlin Gmbh Chemie- Und Pharmawerk Polypeptides possedant de recepteurs actifs de thyrotropine, sequences d'acide nucleique codant pour ces recepteurs et polypetides, et applications de ces polypeptides
EP0433509A3 (en) * 1989-12-14 1991-07-24 Henning Berlin Gmbh Chemie- Und Pharmawerk Polypeptides having thyrotropin receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides
WO1991009121A3 (fr) * 1989-12-14 1991-09-19 Henning Berlin Gmbh Polypeptides possedant de recepteurs actifs de thyrotropine, sequences d'acide nucleique codant pour ces recepteurs et polypetides, et applications de ces polypeptides
WO1991010735A3 (fr) * 1990-01-15 1991-10-03 Inst Nat Sante Rech Med Recepteur humain de la tsh. sequence codant pour ce recepteur
WO1991018628A1 (fr) * 1990-06-08 1991-12-12 Symbicom Aktiebolag Therapie et prophylaxie de maladies auto-immunes
WO1996012189A3 (fr) * 1994-10-07 1996-04-25 Cedars Sini Medical Ct PROCEDES DE DEPISTAGE DE LA RECTOCOLITE HEMORRAGIQUE ET DE LA MALADIE DE CROHN PAR DETECTION DE L'AUTOANTICORPS VH3-15 ET DE pANCA
US5691151A (en) * 1994-10-07 1997-11-25 Regents Of University Of California Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca

Also Published As

Publication number Publication date
AU7160887A (en) 1987-10-09
JPS63502928A (ja) 1988-10-27
DE3790139D2 (en) 1988-08-25
DE3609271A1 (de) 1987-09-24
EP0263135A1 (fr) 1988-04-13

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