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SE9003665D0 - Morphine prodrugs - Google Patents

Morphine prodrugs

Info

Publication number
SE9003665D0
SE9003665D0 SE9003665A SE9003665A SE9003665D0 SE 9003665 D0 SE9003665 D0 SE 9003665D0 SE 9003665 A SE9003665 A SE 9003665A SE 9003665 A SE9003665 A SE 9003665A SE 9003665 D0 SE9003665 D0 SE 9003665D0
Authority
SE
Sweden
Prior art keywords
pct
morphine
date
sec
prodrugs
Prior art date
Application number
SE9003665A
Other languages
English (en)
Swedish (sv)
Inventor
H Bundgaard
Original Assignee
Kabivitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabivitrum Ab filed Critical Kabivitrum Ab
Priority to SE9003665A priority Critical patent/SE9003665D0/xx
Publication of SE9003665D0 publication Critical patent/SE9003665D0/xx
Priority to IE368291A priority patent/IE913682A1/en
Priority to NZ240349A priority patent/NZ240349A/en
Priority to ZA918512A priority patent/ZA918512B/xx
Priority to IL9990591A priority patent/IL99905A/en
Priority to CA002095223A priority patent/CA2095223C/fr
Priority to DK91920399T priority patent/DK0557385T3/da
Priority to AU89381/91A priority patent/AU655612B2/en
Priority to DE69129861T priority patent/DE69129861T2/de
Priority to PCT/SE1991/000760 priority patent/WO1992008459A1/fr
Priority to AT91920399T priority patent/ATE168560T1/de
Priority to US08/050,336 priority patent/US5908846A/en
Priority to JP50056892A priority patent/JP3493434B2/ja
Priority to EP91920399A priority patent/EP0557385B1/fr
Priority to ES91920399T priority patent/ES2121793T3/es
Priority to PT99513A priority patent/PT99513B/pt
Priority to FI932212A priority patent/FI932212L/fi
Priority to NO931766A priority patent/NO931766D0/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
SE9003665A 1990-11-16 1990-11-16 Morphine prodrugs SE9003665D0 (sv)

Priority Applications (18)

Application Number Priority Date Filing Date Title
SE9003665A SE9003665D0 (sv) 1990-11-16 1990-11-16 Morphine prodrugs
IE368291A IE913682A1 (en) 1990-11-16 1991-10-21 Morphine prodrugs
NZ240349A NZ240349A (en) 1990-11-16 1991-10-25 Topical compositions for transdermal delivery of morphine prodrugs
ZA918512A ZA918512B (en) 1990-11-16 1991-10-25 Morphine prodrugs
IL9990591A IL99905A (en) 1990-11-16 1991-10-30 Topical compositions for transdermal delivery of morphine prodrugs
ES91920399T ES2121793T3 (es) 1990-11-16 1991-11-11 Composiciones de uso local para la administracion transdermica de derivados profarmacos de morfina.
DE69129861T DE69129861T2 (de) 1990-11-16 1991-11-11 Topische mittel zur transdermalen verabreichung von prodrugderivaten des morphins
DK91920399T DK0557385T3 (da) 1990-11-16 1991-11-11 Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin
AU89381/91A AU655612B2 (en) 1990-11-16 1991-11-11 Topical compositions for transdermal delivery of produg derivatives of morphine
CA002095223A CA2095223C (fr) 1990-11-16 1991-11-11 Compositions topiques pour l'administration transdermique de derives de precurseurs de morphine
PCT/SE1991/000760 WO1992008459A1 (fr) 1990-11-16 1991-11-11 Compositions a administration locale destinees a l'asministration transdermique de derives de promedicament de morphine
AT91920399T ATE168560T1 (de) 1990-11-16 1991-11-11 Topische mittel zur transdermalen verabreichung von prodrugderivaten des morphins
US08/050,336 US5908846A (en) 1990-11-16 1991-11-11 Topical compositions for transdermal delivery of prodrug derivatives of morphine
JP50056892A JP3493434B2 (ja) 1990-11-16 1991-11-11 モルヒネのプロドラッグ誘導体の経皮供給用の局所組成物
EP91920399A EP0557385B1 (fr) 1990-11-16 1991-11-11 Compositions a administration locale destinees a l'asministration transdermique de derives de promedicament de morphine
PT99513A PT99513B (pt) 1990-11-16 1991-11-14 Processo para a preparacao de composicoes farmaceuticas contendo profarmacos de morfina para administracao topica por via transdermica
FI932212A FI932212L (fi) 1990-11-16 1993-05-14 Topikal kompositioner foer transdermal transmission av morfinets prodrugderivat
NO931766A NO931766D0 (no) 1990-11-16 1993-05-14 Topiske preparater for transdermal avlevering av forloeperlegemiddelderivater av morfin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9003665A SE9003665D0 (sv) 1990-11-16 1990-11-16 Morphine prodrugs

Publications (1)

Publication Number Publication Date
SE9003665D0 true SE9003665D0 (sv) 1990-11-16

Family

ID=20380936

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9003665A SE9003665D0 (sv) 1990-11-16 1990-11-16 Morphine prodrugs

Country Status (18)

Country Link
US (1) US5908846A (fr)
EP (1) EP0557385B1 (fr)
JP (1) JP3493434B2 (fr)
AT (1) ATE168560T1 (fr)
AU (1) AU655612B2 (fr)
CA (1) CA2095223C (fr)
DE (1) DE69129861T2 (fr)
DK (1) DK0557385T3 (fr)
ES (1) ES2121793T3 (fr)
FI (1) FI932212L (fr)
IE (1) IE913682A1 (fr)
IL (1) IL99905A (fr)
NO (1) NO931766D0 (fr)
NZ (1) NZ240349A (fr)
PT (1) PT99513B (fr)
SE (1) SE9003665D0 (fr)
WO (1) WO1992008459A1 (fr)
ZA (1) ZA918512B (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
DE4403709A1 (de) * 1994-02-07 1995-08-10 Lohmann Therapie Syst Lts Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid
JPH07267862A (ja) * 1994-03-29 1995-10-17 Sekisui Chem Co Ltd 経皮吸収貼付剤
AU5108596A (en) * 1995-03-14 1996-10-02 Mundipharma Gmbh Morphine-3-esters
DE19508664C2 (de) * 1995-03-14 2001-08-23 Christian Mignat Verwendung von Morphin-3-estern, Morphin-3-ester als solche und Verfahren zu deren Herstellung
GB9519363D0 (en) 1995-09-22 1995-11-22 Euro Celtique Sa Pharmaceutical formulation
DE19602959A1 (de) * 1995-12-20 1997-07-31 Nycomed Arzneimittel Gmbh Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung
DE19923551A1 (de) * 1999-05-21 2000-11-30 Lohmann Therapie Syst Lts Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
MXPA02004293A (es) 1999-10-29 2002-10-31 Euro Celtique Sa Formulaciones de hidrocodona de liberacion controlada..
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
KR101167465B1 (ko) 2000-10-30 2012-07-27 유로-셀티크 소시에떼 아노뉨 서방성 하이드로코돈 제형
US6569449B1 (en) * 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
AUPR549901A0 (en) 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
WO2002040034A1 (fr) * 2000-11-14 2002-05-23 Vital Health Sciences Pty Ltd. Complexes de derives de phosphate
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
JP4814486B2 (ja) * 2001-06-05 2011-11-16 シヴィダ・インコーポレイテッド 持続放出性鎮痛性化合物
AU2002317053B2 (en) * 2001-07-27 2004-08-05 Vital Health Sciences Pty Ltd Dermal therapy using phosphate derivatives of electron transfer agents
AU2002350272B1 (en) * 2001-12-13 2003-06-23 Vital Health Sciences Pty Ltd Transdermal transport of compounds
AU2002950713A0 (en) * 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
US7084150B2 (en) * 2002-10-25 2006-08-01 Euro-Celtique S.A. Analogs and prodrugs of buprenorphine
US20040152769A1 (en) * 2002-11-09 2004-08-05 Ekwuribe Nnochiri Nkem Modified carbamate-containing prodrugs and methods of synthesizing same
ATE534384T1 (de) * 2003-01-17 2011-12-15 Vital Health Sciences Pty Ltd Verbindungen mit proliferationshemmenden eigenschaften
AU2003901815A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
CN1829489B (zh) * 2003-07-25 2010-12-15 欧洲凯尔特公司 丁丙诺啡在制备术后疼痛的术前治疗药物中的用途
ES2313299T3 (es) * 2004-02-06 2009-03-01 Euro-Celtique S.A. Procedimientos para producir morfinonas 3 o protegidas y carboxilatos de morfinona dienol 3 o protegidos.
CA2556624C (fr) 2004-02-23 2011-11-08 Euro-Celtique S.A. Dispositif de distribution transdermique d'opioides empechant une utilisation abusive et contenant des microspheres d'antagonistes d'opioides
BRPI0508125A (pt) 2004-03-03 2007-07-17 Vital Health Sciences Pty Ltd formulação de alcalóide, método para melhorar a eficácia de um alcalóide, uso do produto da reação de um ou mais alcalóides com um mais derivados de fosfato de um ou mais agentes de transferência de elétrons, junto com excipientes e composição farmacêutica
WO2006133506A1 (fr) 2005-06-17 2006-12-21 Vital Health Sciences Pty Ltd Charge comprenant un ou plusieurs dérivés de di- et/ou monophosphate d’agent de transfert d’électrons ou des complexes de ceux-ci
WO2007070981A1 (fr) * 2005-12-23 2007-06-28 Vital Health Sciences Pty Ltd Composés ayant des propriétés modulatrices de la cytokine
KR101612901B1 (ko) 2007-03-02 2016-04-15 테이카 세이야쿠 가부시키가이샤 경피흡수 의약조성물, 의약조성물 저장유닛 및 이것을 이용하는 경피흡수제제
US9511016B2 (en) * 2007-06-12 2016-12-06 Epicentrx, Inc. Topical composition for treating pain
US8354116B2 (en) * 2007-06-18 2013-01-15 Biochemics, Inc. Bifunctional synthetic molecules
US20090130048A1 (en) * 2007-11-19 2009-05-21 Oronsky Bryan Todd Topical Composition for Treating Pain
US8784872B2 (en) 2007-11-19 2014-07-22 Comgenrx, Inc. Formulation for decreasing tobacco, alcohol, drug or food consumption
US20100104614A1 (en) * 2008-06-27 2010-04-29 Oronsky Bryan T Providone compositions for wound healing
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
UA102916C2 (uk) * 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
CA2765836C (fr) 2009-07-02 2014-10-07 Kempharm, Inc. Conjugues d'acide phenylethanoique, d'acide phenylpropanoique et d'acide phenylpropenoique et promedicaments d'hydrocodone, leurs procedes de fabrication et d'utilisation
EP2531047B1 (fr) 2010-02-05 2024-11-13 Phosphagenics Limited Vecteur comprenant du phosphate de tocophéryle non neutralisé
KR20130010473A (ko) 2010-03-30 2013-01-28 포스파제닉스 리미티드 경피 전달 패치
DK2557924T3 (da) 2010-04-13 2019-09-23 Relmada Therapeutics Inc Dermale farmaceutiske sammensætninger af 1-methyl-2',6'-pipecoloxylidid og fremgangsmåde til deres anvendelse
TWI590821B (zh) 2011-01-18 2017-07-11 輝瑞有限公司 固體分子分散液
WO2012122586A1 (fr) 2011-03-15 2012-09-20 Phosphagenics Limited Nouvelle composition
KR20190049944A (ko) 2014-11-25 2019-05-09 켐팜 인코포레이티드 옥시코돈의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트
US10973761B2 (en) 2015-12-09 2021-04-13 Phosphagenics Limited Pharmaceutical formulation
CA3045702A1 (fr) 2016-12-21 2018-06-28 Phosphagenics Limited Procede de phosphorylation d'alcools complexes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4673679A (en) * 1986-05-14 1987-06-16 E. I. Du Pont De Nemours And Company Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
US4940586A (en) * 1987-02-26 1990-07-10 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4879297A (en) * 1987-06-01 1989-11-07 Warner-Lambert Company Fatty acids and their small chain esters as penetration enhancers in aqueous systems
US4891377A (en) * 1988-12-02 1990-01-02 Board Of Regents Acting For And On Behalf Of University Of Michigan Transdermal delivery of the narcotic analgesics etorphine and analogs
US5240932A (en) * 1990-03-30 1993-08-31 Yasunori Morimoto Percutaneously absorbable compositions of morphine or analogous analgesics of morphine
US5069909A (en) * 1990-06-20 1991-12-03 Cygnus Therapeutic Systems Transdermal administration of buprenorphine

Also Published As

Publication number Publication date
ES2121793T3 (es) 1998-12-16
PT99513A (pt) 1992-09-30
EP0557385A1 (fr) 1993-09-01
IL99905A (en) 1995-06-29
ZA918512B (en) 1992-08-26
NO931766L (no) 1993-05-14
FI932212A0 (fi) 1993-05-14
AU8938191A (en) 1992-06-11
FI932212L (fi) 1993-05-14
AU655612B2 (en) 1995-01-05
IL99905A0 (en) 1992-08-18
PT99513B (pt) 1999-04-30
CA2095223C (fr) 2002-12-17
JP3493434B2 (ja) 2004-02-03
CA2095223A1 (fr) 1992-05-17
DE69129861D1 (de) 1998-08-27
US5908846A (en) 1999-06-01
NO931766D0 (no) 1993-05-14
DE69129861T2 (de) 1999-04-01
ATE168560T1 (de) 1998-08-15
NZ240349A (en) 1993-07-27
DK0557385T3 (da) 1999-04-26
EP0557385B1 (fr) 1998-07-22
JPH06502422A (ja) 1994-03-17
WO1992008459A1 (fr) 1992-05-29
IE913682A1 (en) 1992-05-20

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