SE9003665D0 - Morphine prodrugs - Google Patents
Morphine prodrugsInfo
- Publication number
- SE9003665D0 SE9003665D0 SE9003665A SE9003665A SE9003665D0 SE 9003665 D0 SE9003665 D0 SE 9003665D0 SE 9003665 A SE9003665 A SE 9003665A SE 9003665 A SE9003665 A SE 9003665A SE 9003665 D0 SE9003665 D0 SE 9003665D0
- Authority
- SE
- Sweden
- Prior art keywords
- pct
- morphine
- date
- sec
- prodrugs
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 5
- 229960005181 morphine Drugs 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000037317 transdermal delivery Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9003665A SE9003665D0 (sv) | 1990-11-16 | 1990-11-16 | Morphine prodrugs |
IE368291A IE913682A1 (en) | 1990-11-16 | 1991-10-21 | Morphine prodrugs |
NZ240349A NZ240349A (en) | 1990-11-16 | 1991-10-25 | Topical compositions for transdermal delivery of morphine prodrugs |
ZA918512A ZA918512B (en) | 1990-11-16 | 1991-10-25 | Morphine prodrugs |
IL9990591A IL99905A (en) | 1990-11-16 | 1991-10-30 | Topical compositions for transdermal delivery of morphine prodrugs |
ES91920399T ES2121793T3 (es) | 1990-11-16 | 1991-11-11 | Composiciones de uso local para la administracion transdermica de derivados profarmacos de morfina. |
DE69129861T DE69129861T2 (de) | 1990-11-16 | 1991-11-11 | Topische mittel zur transdermalen verabreichung von prodrugderivaten des morphins |
DK91920399T DK0557385T3 (da) | 1990-11-16 | 1991-11-11 | Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin |
AU89381/91A AU655612B2 (en) | 1990-11-16 | 1991-11-11 | Topical compositions for transdermal delivery of produg derivatives of morphine |
CA002095223A CA2095223C (fr) | 1990-11-16 | 1991-11-11 | Compositions topiques pour l'administration transdermique de derives de precurseurs de morphine |
PCT/SE1991/000760 WO1992008459A1 (fr) | 1990-11-16 | 1991-11-11 | Compositions a administration locale destinees a l'asministration transdermique de derives de promedicament de morphine |
AT91920399T ATE168560T1 (de) | 1990-11-16 | 1991-11-11 | Topische mittel zur transdermalen verabreichung von prodrugderivaten des morphins |
US08/050,336 US5908846A (en) | 1990-11-16 | 1991-11-11 | Topical compositions for transdermal delivery of prodrug derivatives of morphine |
JP50056892A JP3493434B2 (ja) | 1990-11-16 | 1991-11-11 | モルヒネのプロドラッグ誘導体の経皮供給用の局所組成物 |
EP91920399A EP0557385B1 (fr) | 1990-11-16 | 1991-11-11 | Compositions a administration locale destinees a l'asministration transdermique de derives de promedicament de morphine |
PT99513A PT99513B (pt) | 1990-11-16 | 1991-11-14 | Processo para a preparacao de composicoes farmaceuticas contendo profarmacos de morfina para administracao topica por via transdermica |
FI932212A FI932212L (fi) | 1990-11-16 | 1993-05-14 | Topikal kompositioner foer transdermal transmission av morfinets prodrugderivat |
NO931766A NO931766D0 (no) | 1990-11-16 | 1993-05-14 | Topiske preparater for transdermal avlevering av forloeperlegemiddelderivater av morfin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9003665A SE9003665D0 (sv) | 1990-11-16 | 1990-11-16 | Morphine prodrugs |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9003665D0 true SE9003665D0 (sv) | 1990-11-16 |
Family
ID=20380936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9003665A SE9003665D0 (sv) | 1990-11-16 | 1990-11-16 | Morphine prodrugs |
Country Status (18)
Country | Link |
---|---|
US (1) | US5908846A (fr) |
EP (1) | EP0557385B1 (fr) |
JP (1) | JP3493434B2 (fr) |
AT (1) | ATE168560T1 (fr) |
AU (1) | AU655612B2 (fr) |
CA (1) | CA2095223C (fr) |
DE (1) | DE69129861T2 (fr) |
DK (1) | DK0557385T3 (fr) |
ES (1) | ES2121793T3 (fr) |
FI (1) | FI932212L (fr) |
IE (1) | IE913682A1 (fr) |
IL (1) | IL99905A (fr) |
NO (1) | NO931766D0 (fr) |
NZ (1) | NZ240349A (fr) |
PT (1) | PT99513B (fr) |
SE (1) | SE9003665D0 (fr) |
WO (1) | WO1992008459A1 (fr) |
ZA (1) | ZA918512B (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5607691A (en) * | 1992-06-12 | 1997-03-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
DE4403709A1 (de) * | 1994-02-07 | 1995-08-10 | Lohmann Therapie Syst Lts | Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid |
JPH07267862A (ja) * | 1994-03-29 | 1995-10-17 | Sekisui Chem Co Ltd | 経皮吸収貼付剤 |
AU5108596A (en) * | 1995-03-14 | 1996-10-02 | Mundipharma Gmbh | Morphine-3-esters |
DE19508664C2 (de) * | 1995-03-14 | 2001-08-23 | Christian Mignat | Verwendung von Morphin-3-estern, Morphin-3-ester als solche und Verfahren zu deren Herstellung |
GB9519363D0 (en) | 1995-09-22 | 1995-11-22 | Euro Celtique Sa | Pharmaceutical formulation |
DE19602959A1 (de) * | 1995-12-20 | 1997-07-31 | Nycomed Arzneimittel Gmbh | Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung |
DE19923551A1 (de) * | 1999-05-21 | 2000-11-30 | Lohmann Therapie Syst Lts | Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
MXPA02004293A (es) | 1999-10-29 | 2002-10-31 | Euro Celtique Sa | Formulaciones de hidrocodona de liberacion controlada.. |
US20020013331A1 (en) * | 2000-06-26 | 2002-01-31 | Williams Robert O. | Methods and compositions for treating pain of the mucous membrane |
KR101167465B1 (ko) | 2000-10-30 | 2012-07-27 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
US6569449B1 (en) * | 2000-11-13 | 2003-05-27 | University Of Kentucky Research Foundation | Transdermal delivery of opioid antagonist prodrugs |
AUPR549901A0 (en) | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
WO2002040034A1 (fr) * | 2000-11-14 | 2002-05-23 | Vital Health Sciences Pty Ltd. | Complexes de derives de phosphate |
US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
JP4814486B2 (ja) * | 2001-06-05 | 2011-11-16 | シヴィダ・インコーポレイテッド | 持続放出性鎮痛性化合物 |
AU2002317053B2 (en) * | 2001-07-27 | 2004-08-05 | Vital Health Sciences Pty Ltd | Dermal therapy using phosphate derivatives of electron transfer agents |
AU2002350272B1 (en) * | 2001-12-13 | 2003-06-23 | Vital Health Sciences Pty Ltd | Transdermal transport of compounds |
AU2002950713A0 (en) * | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
US7084150B2 (en) * | 2002-10-25 | 2006-08-01 | Euro-Celtique S.A. | Analogs and prodrugs of buprenorphine |
US20040152769A1 (en) * | 2002-11-09 | 2004-08-05 | Ekwuribe Nnochiri Nkem | Modified carbamate-containing prodrugs and methods of synthesizing same |
ATE534384T1 (de) * | 2003-01-17 | 2011-12-15 | Vital Health Sciences Pty Ltd | Verbindungen mit proliferationshemmenden eigenschaften |
AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
CN1829489B (zh) * | 2003-07-25 | 2010-12-15 | 欧洲凯尔特公司 | 丁丙诺啡在制备术后疼痛的术前治疗药物中的用途 |
ES2313299T3 (es) * | 2004-02-06 | 2009-03-01 | Euro-Celtique S.A. | Procedimientos para producir morfinonas 3 o protegidas y carboxilatos de morfinona dienol 3 o protegidos. |
CA2556624C (fr) | 2004-02-23 | 2011-11-08 | Euro-Celtique S.A. | Dispositif de distribution transdermique d'opioides empechant une utilisation abusive et contenant des microspheres d'antagonistes d'opioides |
BRPI0508125A (pt) | 2004-03-03 | 2007-07-17 | Vital Health Sciences Pty Ltd | formulação de alcalóide, método para melhorar a eficácia de um alcalóide, uso do produto da reação de um ou mais alcalóides com um mais derivados de fosfato de um ou mais agentes de transferência de elétrons, junto com excipientes e composição farmacêutica |
WO2006133506A1 (fr) | 2005-06-17 | 2006-12-21 | Vital Health Sciences Pty Ltd | Charge comprenant un ou plusieurs dérivés de di- et/ou monophosphate d’agent de transfert d’électrons ou des complexes de ceux-ci |
WO2007070981A1 (fr) * | 2005-12-23 | 2007-06-28 | Vital Health Sciences Pty Ltd | Composés ayant des propriétés modulatrices de la cytokine |
KR101612901B1 (ko) | 2007-03-02 | 2016-04-15 | 테이카 세이야쿠 가부시키가이샤 | 경피흡수 의약조성물, 의약조성물 저장유닛 및 이것을 이용하는 경피흡수제제 |
US9511016B2 (en) * | 2007-06-12 | 2016-12-06 | Epicentrx, Inc. | Topical composition for treating pain |
US8354116B2 (en) * | 2007-06-18 | 2013-01-15 | Biochemics, Inc. | Bifunctional synthetic molecules |
US20090130048A1 (en) * | 2007-11-19 | 2009-05-21 | Oronsky Bryan Todd | Topical Composition for Treating Pain |
US8784872B2 (en) | 2007-11-19 | 2014-07-22 | Comgenrx, Inc. | Formulation for decreasing tobacco, alcohol, drug or food consumption |
US20100104614A1 (en) * | 2008-06-27 | 2010-04-29 | Oronsky Bryan T | Providone compositions for wound healing |
US10849981B2 (en) | 2009-07-02 | 2020-12-01 | KemPham, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof |
UA102916C2 (uk) * | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань |
CA2765836C (fr) | 2009-07-02 | 2014-10-07 | Kempharm, Inc. | Conjugues d'acide phenylethanoique, d'acide phenylpropanoique et d'acide phenylpropenoique et promedicaments d'hydrocodone, leurs procedes de fabrication et d'utilisation |
EP2531047B1 (fr) | 2010-02-05 | 2024-11-13 | Phosphagenics Limited | Vecteur comprenant du phosphate de tocophéryle non neutralisé |
KR20130010473A (ko) | 2010-03-30 | 2013-01-28 | 포스파제닉스 리미티드 | 경피 전달 패치 |
DK2557924T3 (da) | 2010-04-13 | 2019-09-23 | Relmada Therapeutics Inc | Dermale farmaceutiske sammensætninger af 1-methyl-2',6'-pipecoloxylidid og fremgangsmåde til deres anvendelse |
TWI590821B (zh) | 2011-01-18 | 2017-07-11 | 輝瑞有限公司 | 固體分子分散液 |
WO2012122586A1 (fr) | 2011-03-15 | 2012-09-20 | Phosphagenics Limited | Nouvelle composition |
KR20190049944A (ko) | 2014-11-25 | 2019-05-09 | 켐팜 인코포레이티드 | 옥시코돈의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트 |
US10973761B2 (en) | 2015-12-09 | 2021-04-13 | Phosphagenics Limited | Pharmaceutical formulation |
CA3045702A1 (fr) | 2016-12-21 | 2018-06-28 | Phosphagenics Limited | Procede de phosphorylation d'alcools complexes |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4626539A (en) * | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
US4673679A (en) * | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
US4908389A (en) * | 1986-08-27 | 1990-03-13 | Warner-Lambert Company | Penetration enhancement system |
US4940586A (en) * | 1987-02-26 | 1990-07-10 | Alza Corporation | Skin permeation enhancer compositions using sucrose esters |
US4879297A (en) * | 1987-06-01 | 1989-11-07 | Warner-Lambert Company | Fatty acids and their small chain esters as penetration enhancers in aqueous systems |
US4891377A (en) * | 1988-12-02 | 1990-01-02 | Board Of Regents Acting For And On Behalf Of University Of Michigan | Transdermal delivery of the narcotic analgesics etorphine and analogs |
US5240932A (en) * | 1990-03-30 | 1993-08-31 | Yasunori Morimoto | Percutaneously absorbable compositions of morphine or analogous analgesics of morphine |
US5069909A (en) * | 1990-06-20 | 1991-12-03 | Cygnus Therapeutic Systems | Transdermal administration of buprenorphine |
-
1990
- 1990-11-16 SE SE9003665A patent/SE9003665D0/xx unknown
-
1991
- 1991-10-21 IE IE368291A patent/IE913682A1/en not_active IP Right Cessation
- 1991-10-25 ZA ZA918512A patent/ZA918512B/xx unknown
- 1991-10-25 NZ NZ240349A patent/NZ240349A/en not_active IP Right Cessation
- 1991-10-30 IL IL9990591A patent/IL99905A/en not_active IP Right Cessation
- 1991-11-11 DK DK91920399T patent/DK0557385T3/da active
- 1991-11-11 JP JP50056892A patent/JP3493434B2/ja not_active Expired - Fee Related
- 1991-11-11 CA CA002095223A patent/CA2095223C/fr not_active Expired - Fee Related
- 1991-11-11 EP EP91920399A patent/EP0557385B1/fr not_active Expired - Lifetime
- 1991-11-11 AU AU89381/91A patent/AU655612B2/en not_active Ceased
- 1991-11-11 DE DE69129861T patent/DE69129861T2/de not_active Expired - Fee Related
- 1991-11-11 AT AT91920399T patent/ATE168560T1/de not_active IP Right Cessation
- 1991-11-11 WO PCT/SE1991/000760 patent/WO1992008459A1/fr active IP Right Grant
- 1991-11-11 US US08/050,336 patent/US5908846A/en not_active Expired - Fee Related
- 1991-11-11 ES ES91920399T patent/ES2121793T3/es not_active Expired - Lifetime
- 1991-11-14 PT PT99513A patent/PT99513B/pt not_active IP Right Cessation
-
1993
- 1993-05-14 FI FI932212A patent/FI932212L/fi unknown
- 1993-05-14 NO NO931766A patent/NO931766D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
ES2121793T3 (es) | 1998-12-16 |
PT99513A (pt) | 1992-09-30 |
EP0557385A1 (fr) | 1993-09-01 |
IL99905A (en) | 1995-06-29 |
ZA918512B (en) | 1992-08-26 |
NO931766L (no) | 1993-05-14 |
FI932212A0 (fi) | 1993-05-14 |
AU8938191A (en) | 1992-06-11 |
FI932212L (fi) | 1993-05-14 |
AU655612B2 (en) | 1995-01-05 |
IL99905A0 (en) | 1992-08-18 |
PT99513B (pt) | 1999-04-30 |
CA2095223C (fr) | 2002-12-17 |
JP3493434B2 (ja) | 2004-02-03 |
CA2095223A1 (fr) | 1992-05-17 |
DE69129861D1 (de) | 1998-08-27 |
US5908846A (en) | 1999-06-01 |
NO931766D0 (no) | 1993-05-14 |
DE69129861T2 (de) | 1999-04-01 |
ATE168560T1 (de) | 1998-08-15 |
NZ240349A (en) | 1993-07-27 |
DK0557385T3 (da) | 1999-04-26 |
EP0557385B1 (fr) | 1998-07-22 |
JPH06502422A (ja) | 1994-03-17 |
WO1992008459A1 (fr) | 1992-05-29 |
IE913682A1 (en) | 1992-05-20 |
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