SE9003665D0 - Morphine prodrugs - Google Patents
Morphine prodrugsInfo
- Publication number
- SE9003665D0 SE9003665D0 SE9003665A SE9003665A SE9003665D0 SE 9003665 D0 SE9003665 D0 SE 9003665D0 SE 9003665 A SE9003665 A SE 9003665A SE 9003665 A SE9003665 A SE 9003665A SE 9003665 D0 SE9003665 D0 SE 9003665D0
- Authority
- SE
- Sweden
- Prior art keywords
- pct
- morphine
- date
- sec
- prodrugs
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 5
- 229960005181 morphine Drugs 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000037317 transdermal delivery Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9003665A SE9003665D0 (sv) | 1990-11-16 | 1990-11-16 | Morphine prodrugs |
IE368291A IE913682A1 (en) | 1990-11-16 | 1991-10-21 | Morphine prodrugs |
NZ240349A NZ240349A (en) | 1990-11-16 | 1991-10-25 | Topical compositions for transdermal delivery of morphine prodrugs |
ZA918512A ZA918512B (en) | 1990-11-16 | 1991-10-25 | Morphine prodrugs |
IL9990591A IL99905A (en) | 1990-11-16 | 1991-10-30 | Topical compositions for transdermal delivery of morphine prodrugs |
JP50056892A JP3493434B2 (ja) | 1990-11-16 | 1991-11-11 | モルヒネのプロドラッグ誘導体の経皮供給用の局所組成物 |
CA002095223A CA2095223C (fr) | 1990-11-16 | 1991-11-11 | Compositions topiques pour l'administration transdermique de derives de precurseurs de morphine |
AT91920399T ATE168560T1 (de) | 1990-11-16 | 1991-11-11 | Topische mittel zur transdermalen verabreichung von prodrugderivaten des morphins |
EP91920399A EP0557385B1 (fr) | 1990-11-16 | 1991-11-11 | Compositions a administration locale destinees a l'asministration transdermique de derives de promedicament de morphine |
DE69129861T DE69129861T2 (de) | 1990-11-16 | 1991-11-11 | Topische mittel zur transdermalen verabreichung von prodrugderivaten des morphins |
DK91920399T DK0557385T3 (da) | 1990-11-16 | 1991-11-11 | Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin |
ES91920399T ES2121793T3 (es) | 1990-11-16 | 1991-11-11 | Composiciones de uso local para la administracion transdermica de derivados profarmacos de morfina. |
AU89381/91A AU655612B2 (en) | 1990-11-16 | 1991-11-11 | Topical compositions for transdermal delivery of produg derivatives of morphine |
US08/050,336 US5908846A (en) | 1990-11-16 | 1991-11-11 | Topical compositions for transdermal delivery of prodrug derivatives of morphine |
PCT/SE1991/000760 WO1992008459A1 (fr) | 1990-11-16 | 1991-11-11 | Compositions a administration locale destinees a l'asministration transdermique de derives de promedicament de morphine |
PT99513A PT99513B (pt) | 1990-11-16 | 1991-11-14 | Processo para a preparacao de composicoes farmaceuticas contendo profarmacos de morfina para administracao topica por via transdermica |
NO931766A NO931766D0 (no) | 1990-11-16 | 1993-05-14 | Topiske preparater for transdermal avlevering av forloeperlegemiddelderivater av morfin |
FI932212A FI932212A0 (fi) | 1990-11-16 | 1993-05-14 | Topikal kompositioner foer transdermal transmission av morfinets prodrugderivat |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9003665A SE9003665D0 (sv) | 1990-11-16 | 1990-11-16 | Morphine prodrugs |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9003665D0 true SE9003665D0 (sv) | 1990-11-16 |
Family
ID=20380936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9003665A SE9003665D0 (sv) | 1990-11-16 | 1990-11-16 | Morphine prodrugs |
Country Status (18)
Country | Link |
---|---|
US (1) | US5908846A (fr) |
EP (1) | EP0557385B1 (fr) |
JP (1) | JP3493434B2 (fr) |
AT (1) | ATE168560T1 (fr) |
AU (1) | AU655612B2 (fr) |
CA (1) | CA2095223C (fr) |
DE (1) | DE69129861T2 (fr) |
DK (1) | DK0557385T3 (fr) |
ES (1) | ES2121793T3 (fr) |
FI (1) | FI932212A0 (fr) |
IE (1) | IE913682A1 (fr) |
IL (1) | IL99905A (fr) |
NO (1) | NO931766D0 (fr) |
NZ (1) | NZ240349A (fr) |
PT (1) | PT99513B (fr) |
SE (1) | SE9003665D0 (fr) |
WO (1) | WO1992008459A1 (fr) |
ZA (1) | ZA918512B (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5607691A (en) * | 1992-06-12 | 1997-03-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
DE4403709A1 (de) * | 1994-02-07 | 1995-08-10 | Lohmann Therapie Syst Lts | Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid |
JPH07267862A (ja) * | 1994-03-29 | 1995-10-17 | Sekisui Chem Co Ltd | 経皮吸収貼付剤 |
AU5108596A (en) * | 1995-03-14 | 1996-10-02 | Mundipharma Gmbh | Morphine-3-esters |
DE19508664C2 (de) * | 1995-03-14 | 2001-08-23 | Christian Mignat | Verwendung von Morphin-3-estern, Morphin-3-ester als solche und Verfahren zu deren Herstellung |
GB9519363D0 (en) | 1995-09-22 | 1995-11-22 | Euro Celtique Sa | Pharmaceutical formulation |
DE19602962A1 (de) * | 1995-12-20 | 1997-07-31 | Nycomed Arzneimittel Gmbh | Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung |
DE19923551A1 (de) * | 1999-05-21 | 2000-11-30 | Lohmann Therapie Syst Lts | Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
MXPA02004293A (es) | 1999-10-29 | 2002-10-31 | Euro Celtique Sa | Formulaciones de hidrocodona de liberacion controlada.. |
US20020013331A1 (en) | 2000-06-26 | 2002-01-31 | Williams Robert O. | Methods and compositions for treating pain of the mucous membrane |
KR20030051760A (ko) | 2000-10-30 | 2003-06-25 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
US6569449B1 (en) * | 2000-11-13 | 2003-05-27 | University Of Kentucky Research Foundation | Transdermal delivery of opioid antagonist prodrugs |
US20040097472A1 (en) * | 2000-11-14 | 2004-05-20 | West Simon Michael | Complexes of phosphate derivatives |
AUPR549901A0 (en) | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
US20110104214A1 (en) | 2004-04-15 | 2011-05-05 | Purdue Pharma L.P. | Once-a-day oxycodone formulations |
CA2448665C (fr) * | 2001-06-05 | 2013-01-29 | Control Delivery Systems | Composes analgesiques a liberation continue |
EP1420797A4 (fr) * | 2001-07-27 | 2005-03-02 | Vital Health Sciences Pty Ltd | Therapie dermique mettant en oeuvre des derives de phosphate d'agents de transfert electroniques |
JP4624673B2 (ja) * | 2001-12-13 | 2011-02-02 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | 化合物の経皮輸送 |
AU2002950713A0 (en) | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
WO2004039317A2 (fr) * | 2002-10-25 | 2004-05-13 | Euro-Celtique S.A. | Analogues et promedicaments de buprenorphine |
US20040152769A1 (en) * | 2002-11-09 | 2004-08-05 | Ekwuribe Nnochiri Nkem | Modified carbamate-containing prodrugs and methods of synthesizing same |
BRPI0406484A (pt) * | 2003-01-17 | 2005-12-06 | Vital Health Sciences Pty Ltd | Método de inibição da ocorrência de uma ou mais das seguintes condições: a proliferação de monócitos/macrófagos; ou a proliferação de células do músculo liso; ou a expressão de receptores de cd36; ou a absorção de lipoproteìna de baixa densidade - ldl oxidada, método de alìvio de sintomas de tratamento ou prevenção de aterosclerose; de diabetes; do mal de alzheimer, método de inibição da ocorrência da formação de placas no sistema vascular, método de alìvio da inflamação associada a ocorrência de uma ou de mais das seguintes condições: a proliferação de monócitos, a proliferação de células do músculo liso, a expressão de ldl oxidadas ou de receptor descontaminante, composição farmacêutica, uso de uma quantidade eficaz de um ou mais derivados ou fosfato de um ou mais agentes de transferência de elétrons conjuntamente com um veìculo ou um diluente apropriado, uso de uma quantidade eficaz de um ou mais derivados de fosfato de (alfa)-tocoferol conjuntamente com um veìculo ou um diluente apropriado e uso de uma quantidade eficaz de um ou mais derivados de fosfato de um ou mais agentes de transferência de elétrons selecionados do grupo que consiste em fosfato mono-tocoferila, fosfato de di-tocoferila e as misturas destes conjuntamente com um veìculo ou um diluente apropriado |
AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
KR20060054346A (ko) * | 2003-07-25 | 2006-05-22 | 유로-셀띠끄 소시에떼 아노님 | 수술후 통증의 수술전 치료 |
ATE406372T1 (de) | 2004-02-06 | 2008-09-15 | Euro Celtique Sa | Verfahren zur herstellung von 3-o-geschützten morphinonen und 3-o-geschützten morphinondienolcarboxylaten |
WO2005081825A2 (fr) | 2004-02-23 | 2005-09-09 | Euro-Celtique S.A. | Dispositif de distribution transdermique d'opioides empechant une utilisation abusive et contenant des microspheres d'antagonistes d'opioides |
WO2005084678A1 (fr) | 2004-03-03 | 2005-09-15 | Vital Health Sciences Pty Ltd | Formulations alcaloides |
EP2548581A3 (fr) | 2005-06-17 | 2013-02-20 | Vital Health Sciences Pty Ltd. | Support comprenant un ou plusieurs dérivés de di et/ou monophosphate (agent de transfert d'électrons) ou des complexes de ceux-ci |
BRPI0621081A2 (pt) * | 2005-12-23 | 2011-11-29 | Vital Health Sciences Pty Ltd | método de modulação de uma ou mais citocinas imuno-reguladoras, uso de um ou mais derivados de fosfato de um ou mais hidróxi cromanos ou complexos dos mesmos, método de inibição de uma resposta inflamatória e/ou de estimulação de uma resposta anti-inflamatória, método de tratamento e/ou de profilaxia de distúbios imunológicos, distúrbios inflamatórios e/ou distúrbios proliferativos celulares, agente imuno-modulador, agente anti-inflamatório ou agente anti-cáncer e um ou mais derivado de fosfato de um ou mais hidróxi cromanos ou complexos dos mesmos |
JP5313868B2 (ja) | 2007-03-02 | 2013-10-09 | テイカ製薬株式会社 | 経皮吸収医薬組成物、医薬組成物貯蔵ユニットおよびこれを利用する経皮吸収製剤 |
US9511016B2 (en) * | 2007-06-12 | 2016-12-06 | Epicentrx, Inc. | Topical composition for treating pain |
US8354116B2 (en) * | 2007-06-18 | 2013-01-15 | Biochemics, Inc. | Bifunctional synthetic molecules |
US8784872B2 (en) | 2007-11-19 | 2014-07-22 | Comgenrx, Inc. | Formulation for decreasing tobacco, alcohol, drug or food consumption |
US20090130048A1 (en) * | 2007-11-19 | 2009-05-21 | Oronsky Bryan Todd | Topical Composition for Treating Pain |
US20100104614A1 (en) * | 2008-06-27 | 2010-04-29 | Oronsky Bryan T | Providone compositions for wound healing |
US10849981B2 (en) | 2009-07-02 | 2020-12-01 | KemPham, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof |
UA102916C2 (uk) * | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань |
AU2010266209B2 (en) | 2009-07-02 | 2013-09-26 | Kempharm, Inc. | Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof |
EP2531047B1 (fr) | 2010-02-05 | 2024-11-13 | Phosphagenics Limited | Vecteur comprenant du phosphate de tocophéryle non neutralisé |
BR112012024835A2 (pt) | 2010-03-30 | 2016-06-07 | Phosphagenics Ltd | adesivo de distribuição transdérmica |
WO2011130455A1 (fr) | 2010-04-13 | 2011-10-20 | Najib Babul | Compositions pharmaceutiques dermiques de 1-méthyl-2',6'-pipécoloxylidide et méthode d'utilisation |
TWI590821B (zh) | 2011-01-18 | 2017-07-11 | 輝瑞有限公司 | 固體分子分散液 |
EP2685992A4 (fr) | 2011-03-15 | 2014-09-10 | Phosphagenics Ltd | Amino-quinoléines en tant qu'inhibiteurs de kinase |
CN106999486A (zh) | 2014-11-25 | 2017-08-01 | 凯姆制药公司 | 羟考酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物 |
WO2017096427A1 (fr) | 2015-12-09 | 2017-06-15 | Phosphagenics Limited | Formulation pharmaceutique |
WO2018112512A1 (fr) | 2016-12-21 | 2018-06-28 | Phosphagenics Limited | Procédé |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4626539A (en) * | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
US4673679A (en) * | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
US4908389A (en) * | 1986-08-27 | 1990-03-13 | Warner-Lambert Company | Penetration enhancement system |
US4940586A (en) * | 1987-02-26 | 1990-07-10 | Alza Corporation | Skin permeation enhancer compositions using sucrose esters |
US4879297A (en) * | 1987-06-01 | 1989-11-07 | Warner-Lambert Company | Fatty acids and their small chain esters as penetration enhancers in aqueous systems |
US4891377A (en) * | 1988-12-02 | 1990-01-02 | Board Of Regents Acting For And On Behalf Of University Of Michigan | Transdermal delivery of the narcotic analgesics etorphine and analogs |
EP0480054B1 (fr) * | 1990-03-30 | 1996-10-02 | Morimoto, Yasunori | Composition absorbable par voie percutanee du chlorhydrate de morphine |
US5069909A (en) * | 1990-06-20 | 1991-12-03 | Cygnus Therapeutic Systems | Transdermal administration of buprenorphine |
-
1990
- 1990-11-16 SE SE9003665A patent/SE9003665D0/xx unknown
-
1991
- 1991-10-21 IE IE368291A patent/IE913682A1/en not_active IP Right Cessation
- 1991-10-25 NZ NZ240349A patent/NZ240349A/en not_active IP Right Cessation
- 1991-10-25 ZA ZA918512A patent/ZA918512B/xx unknown
- 1991-10-30 IL IL9990591A patent/IL99905A/en not_active IP Right Cessation
- 1991-11-11 JP JP50056892A patent/JP3493434B2/ja not_active Expired - Fee Related
- 1991-11-11 DE DE69129861T patent/DE69129861T2/de not_active Expired - Fee Related
- 1991-11-11 EP EP91920399A patent/EP0557385B1/fr not_active Expired - Lifetime
- 1991-11-11 WO PCT/SE1991/000760 patent/WO1992008459A1/fr active IP Right Grant
- 1991-11-11 US US08/050,336 patent/US5908846A/en not_active Expired - Fee Related
- 1991-11-11 ES ES91920399T patent/ES2121793T3/es not_active Expired - Lifetime
- 1991-11-11 DK DK91920399T patent/DK0557385T3/da active
- 1991-11-11 AU AU89381/91A patent/AU655612B2/en not_active Ceased
- 1991-11-11 AT AT91920399T patent/ATE168560T1/de not_active IP Right Cessation
- 1991-11-11 CA CA002095223A patent/CA2095223C/fr not_active Expired - Fee Related
- 1991-11-14 PT PT99513A patent/PT99513B/pt not_active IP Right Cessation
-
1993
- 1993-05-14 NO NO931766A patent/NO931766D0/no unknown
- 1993-05-14 FI FI932212A patent/FI932212A0/fi unknown
Also Published As
Publication number | Publication date |
---|---|
IL99905A0 (en) | 1992-08-18 |
NZ240349A (en) | 1993-07-27 |
FI932212L (fi) | 1993-05-14 |
JP3493434B2 (ja) | 2004-02-03 |
CA2095223C (fr) | 2002-12-17 |
ZA918512B (en) | 1992-08-26 |
CA2095223A1 (fr) | 1992-05-17 |
IE913682A1 (en) | 1992-05-20 |
ES2121793T3 (es) | 1998-12-16 |
US5908846A (en) | 1999-06-01 |
DE69129861T2 (de) | 1999-04-01 |
NO931766L (no) | 1993-05-14 |
EP0557385B1 (fr) | 1998-07-22 |
NO931766D0 (no) | 1993-05-14 |
IL99905A (en) | 1995-06-29 |
WO1992008459A1 (fr) | 1992-05-29 |
PT99513A (pt) | 1992-09-30 |
AU655612B2 (en) | 1995-01-05 |
DE69129861D1 (de) | 1998-08-27 |
EP0557385A1 (fr) | 1993-09-01 |
AU8938191A (en) | 1992-06-11 |
FI932212A0 (fi) | 1993-05-14 |
ATE168560T1 (de) | 1998-08-15 |
DK0557385T3 (da) | 1999-04-26 |
PT99513B (pt) | 1999-04-30 |
JPH06502422A (ja) | 1994-03-17 |
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