SE9003665D0 - Morphine prodrugs - Google Patents

Morphine prodrugs

Info

Publication number: SE9003665D0
Authority: SE; Sweden
Prior art keywords: pct; morphine; date; sec; prodrugs
Prior art date: 1990-11-16

Application number

SE9003665A

Other languages

English (en)

Inventor

H Bundgaard

Original Assignee

Kabivitrum Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-16

Filing date

1990-11-16

Publication date

1990-11-16

1990-11-16 Application filed by Kabivitrum Ab filed Critical Kabivitrum Ab

1990-11-16 Priority to SE9003665A priority Critical patent/SE9003665D0/sv

1990-11-16 Publication of SE9003665D0 publication Critical patent/SE9003665D0/sv

1991-10-21 Priority to IE368291A priority patent/IE913682A1/en

1991-10-25 Priority to ZA918512A priority patent/ZA918512B/xx

1991-10-25 Priority to NZ240349A priority patent/NZ240349A/en

1991-10-30 Priority to IL9990591A priority patent/IL99905A/en

1991-11-11 Priority to ES91920399T priority patent/ES2121793T3/es

1991-11-11 Priority to US08/050,336 priority patent/US5908846A/en

1991-11-11 Priority to CA002095223A priority patent/CA2095223C/en

1991-11-11 Priority to EP91920399A priority patent/EP0557385B1/en

1991-11-11 Priority to AU89381/91A priority patent/AU655612B2/en

1991-11-11 Priority to DE69129861T priority patent/DE69129861T2/de

1991-11-11 Priority to DK91920399T priority patent/DK0557385T3/da

1991-11-11 Priority to JP50056892A priority patent/JP3493434B2/ja

1991-11-11 Priority to PCT/SE1991/000760 priority patent/WO1992008459A1/en

1991-11-11 Priority to AT91920399T priority patent/ATE168560T1/de

1991-11-14 Priority to PT99513A priority patent/PT99513B/pt

1993-05-14 Priority to NO93931766A priority patent/NO931766L/no

1993-05-14 Priority to FI932212A priority patent/FI932212A0/fi

Links

BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 5
229960005181 morphine Drugs 0.000 title abstract 2
229940002612 prodrug Drugs 0.000 title 1
239000000651 prodrug Substances 0.000 title 1
239000000203 mixture Substances 0.000 abstract 3
241000124008 Mammalia Species 0.000 abstract 1
230000037317 transdermal delivery Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

SE9003665A 1990-11-16 1990-11-16 Morphine prodrugs SE9003665D0 (sv)

Priority Applications (18)

Application Number	Priority Date	Filing Date	Title
SE9003665A SE9003665D0 (sv)	1990-11-16	1990-11-16	Morphine prodrugs
IE368291A IE913682A1 (en)	1990-11-16	1991-10-21	Morphine prodrugs
ZA918512A ZA918512B (en)	1990-11-16	1991-10-25	Morphine prodrugs
NZ240349A NZ240349A (en)	1990-11-16	1991-10-25	Topical compositions for transdermal delivery of morphine prodrugs
IL9990591A IL99905A (en)	1990-11-16	1991-10-30	Topical compositions for transdermal delivery of morphine prodrugs
AT91920399T ATE168560T1 (de)	1990-11-16	1991-11-11	Topische mittel zur transdermalen verabreichung von prodrugderivaten des morphins
EP91920399A EP0557385B1 (en)	1990-11-16	1991-11-11	Topical compositions for transdermal delivery of produg derivatives of morphine
US08/050,336 US5908846A (en)	1990-11-16	1991-11-11	Topical compositions for transdermal delivery of prodrug derivatives of morphine
CA002095223A CA2095223C (en)	1990-11-16	1991-11-11	Topical compositions for transdermal delivery of prodrug derivatives of morphine
ES91920399T ES2121793T3 (es)	1990-11-16	1991-11-11	Composiciones de uso local para la administracion transdermica de derivados profarmacos de morfina.
AU89381/91A AU655612B2 (en)	1990-11-16	1991-11-11	Topical compositions for transdermal delivery of produg derivatives of morphine
DE69129861T DE69129861T2 (de)	1990-11-16	1991-11-11	Topische mittel zur transdermalen verabreichung von prodrugderivaten des morphins
DK91920399T DK0557385T3 (da)	1990-11-16	1991-11-11	Topiske sammensætninger til transdermal afgivelse af prodrug-derivater af morfin
JP50056892A JP3493434B2 (ja)	1990-11-16	1991-11-11	モルヒネのプロドラッグ誘導体の経皮供給用の局所組成物
PCT/SE1991/000760 WO1992008459A1 (en)	1990-11-16	1991-11-11	Topical compositions for transdermal delivery of produg derivatives of morphine
PT99513A PT99513B (pt)	1990-11-16	1991-11-14	Processo para a preparacao de composicoes farmaceuticas contendo profarmacos de morfina para administracao topica por via transdermica
NO93931766A NO931766L (no)	1990-11-16	1993-05-14	Topiske preparater for transdermal avlevering av forloeperlegemiddelderivater av morfin
FI932212A FI932212A0 (fi)	1990-11-16	1993-05-14	Topikal kompositioner foer transdermal transmission av morfinets prodrugderivat

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9003665A SE9003665D0 (sv)	1990-11-16	1990-11-16	Morphine prodrugs

Publications (1)

Publication Number	Publication Date
SE9003665D0 true SE9003665D0 (sv)	1990-11-16

Family

ID=20380936

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE9003665A SE9003665D0 (sv)	1990-11-16	1990-11-16	Morphine prodrugs

Country Status (18)

Country	Link
US (1)	US5908846A (sv)
EP (1)	EP0557385B1 (sv)
JP (1)	JP3493434B2 (sv)
AT (1)	ATE168560T1 (sv)
AU (1)	AU655612B2 (sv)
CA (1)	CA2095223C (sv)
DE (1)	DE69129861T2 (sv)
DK (1)	DK0557385T3 (sv)
ES (1)	ES2121793T3 (sv)
FI (1)	FI932212A0 (sv)
IE (1)	IE913682A1 (sv)
IL (1)	IL99905A (sv)
NO (1)	NO931766L (sv)
NZ (1)	NZ240349A (sv)
PT (1)	PT99513B (sv)
SE (1)	SE9003665D0 (sv)
WO (1)	WO1992008459A1 (sv)
ZA (1)	ZA918512B (sv)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5607691A (en) *	1992-06-12	1997-03-04	Affymax Technologies N.V.	Compositions and methods for enhanced drug delivery
DE4403709A1 (de) *	1994-02-07	1995-08-10	Lohmann Therapie Syst Lts	Pharmazeutische Zusammensetzung zur systemischen transdermalen Verabreichung mit dem Wirkstoff Morphin-6-glucuronid
JPH07267862A (ja) *	1994-03-29	1995-10-17	Sekisui Chem Co Ltd	経皮吸収貼付剤
AU5108596A (en) *	1995-03-14	1996-10-02	Mundipharma Gmbh	Morphine-3-esters
DE19508664C2 (de) *	1995-03-14	2001-08-23	Christian Mignat	Verwendung von Morphin-3-estern, Morphin-3-ester als solche und Verfahren zu deren Herstellung
GB9519363D0 (en)	1995-09-22	1995-11-22	Euro Celtique Sa	Pharmaceutical formulation
DE19602968A1 (de) *	1995-12-20	1997-07-31	Nycomed Arzneimittel Gmbh	Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung
DE19923551A1 (de) *	1999-05-21	2000-11-30	Lohmann Therapie Syst Lts	Pharmazeutisches Präparat mit dem Wirkstoff Diamorphin und seine Verwendung in einem Verfahren zur Behandlung der Opiatsucht
EP1623703B1 (en)	1999-10-29	2011-10-05	Euro-Celtique S.A.	Controlled release hydrocodone formulations
US10179130B2 (en)	1999-10-29	2019-01-15	Purdue Pharma L.P.	Controlled release hydrocodone formulations
US20020013331A1 (en)	2000-06-26	2002-01-31	Williams Robert O.	Methods and compositions for treating pain of the mucous membrane
AU2002227383B2 (en)	2000-10-30	2004-07-08	Euro-Celtique S.A.	Controlled release hydrocodone formulations
US6569449B1 (en) *	2000-11-13	2003-05-27	University Of Kentucky Research Foundation	Transdermal delivery of opioid antagonist prodrugs
CA2426885C (en) *	2000-11-14	2010-06-29	Vital Health Sciences Pty Ltd	Complexes of phosphate derivatives
AUPR549901A0 (en)	2001-06-06	2001-07-12	Vital Health Sciences Pty Ltd	Topical formulation containing tocopheryl phosphates
US20110104214A1 (en)	2004-04-15	2011-05-05	Purdue Pharma L.P.	Once-a-day oxycodone formulations
BR0210179A (pt) *	2001-06-05	2004-04-27	Control Delivery Sys Inc	Compostos analgésicos de liberação sustentada
EP1420797A4 (en) *	2001-07-27	2005-03-02	Vital Health Sciences Pty Ltd	DERMAL THERAPY USING PHOSPHATE DERIVATIVES OF ELECTRONIC TRANSFER AGENTS
ATE487456T1 (de) *	2001-12-13	2010-11-15	Vital Health Sciences Pty Ltd	Transdermaler transport von verbindungen
AU2002950713A0 (en)	2002-08-09	2002-09-12	Vital Health Sciences Pty Ltd	Carrier
DE60329515D1 (de) *	2002-10-25	2009-11-12	Euro Celtique Sa	Analoga und prodrugs von buprenorphin
US20040152769A1 (en) *	2002-11-09	2004-08-05	Ekwuribe Nnochiri Nkem	Modified carbamate-containing prodrugs and methods of synthesizing same
MXPA05007278A (es) *	2003-01-17	2005-09-30	Vital Health Sciences Pty Ltd	Compuestos que tienen propiedades anti-proliferativas.
AU2003901815A0 (en) *	2003-04-15	2003-05-01	Vital Health Sciences Pty Ltd	Phosphate derivatives
BRPI0412924A (pt) *	2003-07-25	2006-09-26	Euro Celtique Sa	tratamento pré-operatório de dor pós-operatória
KR100921695B1 (ko) *	2004-02-06	2009-10-15	유로-셀띠끄 소시에떼 아노님	3-ｏ-보호된 모르피논 및 3-ｏ-보호된 모르피논 디엔올카르복실레이트 제조방법
DE602005013490D1 (de)	2004-02-23	2009-05-07	Euro Celtique Sa	Missbrauchsichere transdermale abgabevorrichtung für opioide, enthaltend opioidantagonist in form von mikrokügelchen
RU2477136C2 (ru)	2004-03-03	2013-03-10	Вайтал Хэлф Сайнсис Пти Лтд	Алкалоидные составы
CA2611831C (en)	2005-06-17	2014-09-16	Vital Health Sciences Pty Ltd.	A carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
WO2007070981A1 (en) *	2005-12-23	2007-06-28	Vital Health Sciences Pty Ltd	Compounds having cytokine modulating properties
RU2428186C2 (ru)	2007-03-02	2011-09-10	Теика Фармасьютикал Ко., Лтд.	Лекарственная композиция для чрескожной абсорбции, изделие, сохраняющее лекарственную композицию, и содержащий ее препарат для чрескожной абсорбции
US9511016B2 (en) *	2007-06-12	2016-12-06	Epicentrx, Inc.	Topical composition for treating pain
US8354116B2 (en) *	2007-06-18	2013-01-15	Biochemics, Inc.	Bifunctional synthetic molecules
US8784872B2 (en)	2007-11-19	2014-07-22	Comgenrx, Inc.	Formulation for decreasing tobacco, alcohol, drug or food consumption
US20090130048A1 (en) *	2007-11-19	2009-05-21	Oronsky Bryan Todd	Topical Composition for Treating Pain
WO2009158667A2 (en) *	2008-06-27	2009-12-30	Comgenrx, Inc.	Povidone compositions for wound healing
UA102916C2 (uk)	2009-07-02	2013-08-27	Кемфарм, Інк.	Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en)	2009-07-02	2020-12-01	KemPham, Inc.	Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
CA2765836C (en)	2009-07-02	2014-10-07	Kempharm, Inc.	Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof
US10071030B2 (en)	2010-02-05	2018-09-11	Phosphagenics Limited	Carrier comprising non-neutralised tocopheryl phosphate
CN102821791B (zh)	2010-03-30	2015-06-17	磷肌酸有限公司	透皮递送贴剂
KR101955175B1 (ko)	2010-04-13	2019-03-06	나지브 바불	1-메틸-2'-6'-피페콜옥실리디드의 피부 약제학적 조성물 및 사용 방법
TWI520732B (zh)	2011-01-18	2016-02-11	輝瑞有限公司	固體分子分散液
US9561243B2 (en)	2011-03-15	2017-02-07	Phosphagenics Limited	Composition comprising non-neutralised tocol phosphate and a vitamin A compound
US9850252B2 (en)	2014-11-25	2017-12-26	Kempharm, Inc.	Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone, prodrugs, methods of making and use thereof
JP6882321B2 (ja)	2015-12-09	2021-06-02	フォスファージニクスリミテッド	医薬製剤
US20190330260A1 (en)	2016-12-21	2019-10-31	Avecho Biotechnology Limited	Process

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4626539A (en) *	1984-08-10	1986-12-02	E. I. Dupont De Nemours And Company	Trandermal delivery of opioids
US4673679A (en) *	1986-05-14	1987-06-16	E. I. Du Pont De Nemours And Company	Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
US4908389A (en) *	1986-08-27	1990-03-13	Warner-Lambert Company	Penetration enhancement system
US4940586A (en) *	1987-02-26	1990-07-10	Alza Corporation	Skin permeation enhancer compositions using sucrose esters
US4879297A (en) *	1987-06-01	1989-11-07	Warner-Lambert Company	Fatty acids and their small chain esters as penetration enhancers in aqueous systems
US4891377A (en) *	1988-12-02	1990-01-02	Board Of Regents Acting For And On Behalf Of University Of Michigan	Transdermal delivery of the narcotic analgesics etorphine and analogs
ATE143603T1 (de) *	1990-03-30	1996-10-15	Yasunori Morimoto	Transdermal absorbierbares mittel mit morphin hydrochlorid
US5069909A (en) *	1990-06-20	1991-12-03	Cygnus Therapeutic Systems	Transdermal administration of buprenorphine

1990
- 1990-11-16 SE SE9003665A patent/SE9003665D0/sv unknown
1991
- 1991-10-21 IE IE368291A patent/IE913682A1/en not_active IP Right Cessation
- 1991-10-25 ZA ZA918512A patent/ZA918512B/xx unknown
- 1991-10-25 NZ NZ240349A patent/NZ240349A/en not_active IP Right Cessation
- 1991-10-30 IL IL9990591A patent/IL99905A/en not_active IP Right Cessation
- 1991-11-11 DE DE69129861T patent/DE69129861T2/de not_active Expired - Fee Related
- 1991-11-11 AU AU89381/91A patent/AU655612B2/en not_active Ceased
- 1991-11-11 AT AT91920399T patent/ATE168560T1/de not_active IP Right Cessation
- 1991-11-11 WO PCT/SE1991/000760 patent/WO1992008459A1/en active IP Right Grant
- 1991-11-11 ES ES91920399T patent/ES2121793T3/es not_active Expired - Lifetime
- 1991-11-11 CA CA002095223A patent/CA2095223C/en not_active Expired - Fee Related
- 1991-11-11 JP JP50056892A patent/JP3493434B2/ja not_active Expired - Fee Related
- 1991-11-11 DK DK91920399T patent/DK0557385T3/da active
- 1991-11-11 US US08/050,336 patent/US5908846A/en not_active Expired - Fee Related
- 1991-11-11 EP EP91920399A patent/EP0557385B1/en not_active Expired - Lifetime
- 1991-11-14 PT PT99513A patent/PT99513B/pt not_active IP Right Cessation
1993
- 1993-05-14 NO NO93931766A patent/NO931766L/no unknown
- 1993-05-14 FI FI932212A patent/FI932212A0/fi unknown

Also Published As

Publication number	Publication date
ATE168560T1 (de)	1998-08-15
JP3493434B2 (ja)	2004-02-03
CA2095223A1 (en)	1992-05-17
WO1992008459A1 (en)	1992-05-29
IL99905A (en)	1995-06-29
DK0557385T3 (da)	1999-04-26
CA2095223C (en)	2002-12-17
US5908846A (en)	1999-06-01
AU8938191A (en)	1992-06-11
FI932212L (fi)	1993-05-14
DE69129861T2 (de)	1999-04-01
AU655612B2 (en)	1995-01-05
EP0557385A1 (en)	1993-09-01
IE913682A1 (en)	1992-05-20
FI932212A0 (fi)	1993-05-14
IL99905A0 (en)	1992-08-18
DE69129861D1 (de)	1998-08-27
PT99513A (pt)	1992-09-30
NO931766D0 (no)	1993-05-14
ES2121793T3 (es)	1998-12-16
NZ240349A (en)	1993-07-27
JPH06502422A (ja)	1994-03-17
ZA918512B (en)	1992-08-26
EP0557385B1 (en)	1998-07-22
NO931766L (no)	1993-05-14
PT99513B (pt)	1999-04-30

Publication	Publication Date	Title
SE9003665D0 (sv)	1990-11-16	Morphine prodrugs
MY107158A (en)	1995-09-30	3-arylcarbonyl; -1h-indoles useful as therapeutic agents.
CY2431B1 (en)	2004-11-12	Novel phenanthridines substituted in the 6 position.
GB2270075B (en)	1995-01-04	Substituted 2-phenyl-3-methoxypropenoate fungicides
FI954963A0 (sv)	1995-10-18	Poly-1-n-alkenaminer och dessa innehållande bränsle- och smörjmedelskompositioner
MX9700886A (es)	1998-04-30	Nuevas oxazolidinonas sustituidas.
ATE185548T1 (de)	1999-10-15	Verwendung von n-arylmethylen ethylendiamintriacetate, n-arylmethylen iminodiacetat oder n,n'-diarylmethylen ethylendiamindiacetat gegen oxidativen stress
SI0882021T1 (en)	2003-10-31	New phenanthridines
ZA913213B (en)	1992-02-26	Nail enamels containing glyceryl,glycol or citrate esters
IL104489A0 (en)	1993-05-13	Carbamates and crop protection agents containing them
MX9203319A (es)	1992-07-31	Metodo para la preparacion de cristales de alfa-2 interferona.
BR0009524A (pt)	2002-02-19	Uso de um composto, e, composição farmacêutica ou veterinaria
MY106109A (en)	1995-03-31	3-arylcarbonyl-1-aminoalkyl-1h-indole-containing antiglaucoma compositions
GEP20032953B (en)	2003-04-25	Antitumor Agents
NZ332215A (en)	2000-09-29	Transdermally administered dextromethorphan as antitussive agent
MX9709398A (es)	1998-07-31	N-aril-1,2,4-triazolin-5-onas.
TR199900951T2 (xx)	1999-07-21	G��s kanserinin engellenmesi i�in y�ntemler.
DE69104448D1 (de)	1994-11-10	Faserbehandlungsmittelzusammensetzung.
IT1243193B (it)	1994-05-24	Composizioni farmaceutiche orali a base di melatonina
DK0662837T3 (da)	1999-11-08	Anvendelse af IL-10 til forhindring af insulinafhængig diabetes mellitus
DK0550580T3 (da)	2000-12-04	Inaktivator for uracilreduktase
DK0458589T3 (da)	1995-04-03	Behandling af okulær hypertension med en okulær synergistisk kombination
DE59000613D1 (de)	1993-02-04	Pflaster zur transdermalen anwendung.
DE69426021D1 (de)	2000-11-02	Xamonelin-Tartrat
DK0669826T3 (da)	1999-05-25	(-)-Metrifonatholdigt lægemiddel

SE9003665D0 - Morphine prodrugs - Google Patents

Info

Links

Classifications

Landscapes

Priority Applications (18)

Applications Claiming Priority (1)

Publications (1)

Family

ID=20380936

Family Applications (1)

Country Status (18)

Families Citing this family (47)

Family Cites Families (8)

Also Published As

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