PT81393B - Processo para a preparacao de agentes anti-inflamatorios oxindolicos - Google Patents
Processo para a preparacao de agentes anti-inflamatorios oxindolicosInfo
- Publication number
- PT81393B PT81393B PT81393A PT8139385A PT81393B PT 81393 B PT81393 B PT 81393B PT 81393 A PT81393 A PT 81393A PT 8139385 A PT8139385 A PT 8139385A PT 81393 B PT81393 B PT 81393B
- Authority
- PT
- Portugal
- Prior art keywords
- oxindolic
- preparation
- inflammatory agents
- inflammatory
- agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/666,953 US4644005A (en) | 1984-10-31 | 1984-10-31 | Oxindole antiinflammatory agents |
| US06/762,998 US4686224A (en) | 1984-10-31 | 1985-08-06 | Oxindole antiinflammatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT81393A PT81393A (en) | 1985-11-01 |
| PT81393B true PT81393B (pt) | 1988-02-17 |
Family
ID=27099577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT81393A PT81393B (pt) | 1984-10-31 | 1985-10-29 | Processo para a preparacao de agentes anti-inflamatorios oxindolicos |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4686224A (pt) |
| EP (1) | EP0181136B1 (pt) |
| KR (1) | KR870001269B1 (pt) |
| AU (1) | AU555051B2 (pt) |
| CA (1) | CA1247099A (pt) |
| DE (1) | DE3585719D1 (pt) |
| DK (1) | DK163990C (pt) |
| ES (1) | ES8707731A1 (pt) |
| FI (1) | FI81340C (pt) |
| GR (1) | GR852629B (pt) |
| HU (1) | HU194168B (pt) |
| IE (1) | IE58207B1 (pt) |
| IL (1) | IL76854A (pt) |
| PH (3) | PH20985A (pt) |
| PL (2) | PL150842B1 (pt) |
| PT (1) | PT81393B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU215112B (hu) * | 1989-01-10 | 1998-12-28 | Pfizer Inc. | Eljárás gyulladáscsökkentő 1-heteroaril-3-acil-2-oxindol-származékok előállítására |
| US5128352A (en) * | 1989-01-10 | 1992-07-07 | Pfizer Inc. | Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides |
| JPH0717589B2 (ja) * | 1990-01-22 | 1995-03-01 | ファイザー製薬株式会社 | 新規１，３―ジカルボニル化合物およびその組成物 |
| CH687764A5 (de) * | 1992-07-02 | 1997-02-14 | Lonza Ag Gampel Wallis Geschof | Verfahren zur Herstellung von 7-Acylindolen. |
| US5449788A (en) * | 1994-01-28 | 1995-09-12 | Catalytica, Inc. | Process for preparing 2-oxindole-1-carboxamides |
| GB9414139D0 (en) * | 1994-07-13 | 1994-08-31 | Smithkline Beecham Plc | Novel compounds |
| CN102050758A (zh) * | 2000-09-14 | 2011-05-11 | 田边三菱制药株式会社 | 酰胺衍生物及其制备药物的用途 |
| US7186745B2 (en) | 2001-03-06 | 2007-03-06 | Astrazeneca Ab | Indolone derivatives having vascular damaging activity |
| ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
| WO2005041957A1 (en) * | 2003-10-29 | 2005-05-12 | Pfizer Products Inc. | Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors |
| SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
| KR20090071598A (ko) | 2006-09-18 | 2009-07-01 | 랩터 파마슈티컬 인코포레이티드 | 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료 |
| NZ616673A (en) | 2009-02-20 | 2014-08-29 | To Bbb Holding B V | Glutathione-based drug delivery system |
| MX376331B (es) | 2009-05-06 | 2025-03-07 | Laboratory Skin Care Inc | Composiciones de administracion dermica que comprenden complejos de particulas de fosfato de calcio-agente activo y metodos para utilizar las mismas |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| CN104130176A (zh) * | 2014-06-13 | 2014-11-05 | 天津科技大学 | 一种1,5-二取代吲哚酮类衍生物及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE756447A (fr) * | 1969-10-15 | 1971-03-22 | Pfizer | Oxindolecarboxamides |
| US3749731A (en) * | 1971-07-08 | 1973-07-31 | Warner Lambert Co | 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide |
| DE3114351A1 (de) * | 1981-04-09 | 1982-11-04 | Hoechst Ag, 6000 Frankfurt | "oxindol-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit neuroanaboler wirkung" |
| AU8509882A (en) * | 1981-06-30 | 1983-01-06 | Merck & Co., Inc. | Tricyclic derivatives of substituted pyrrole acids |
| DE3568776D1 (en) * | 1984-02-07 | 1989-04-20 | Pfizer | 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents |
| US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
| CA1250832A (en) * | 1984-03-19 | 1989-03-07 | Pfizer | Process for making 2-oxindole-1-carboxamides and intermediates therefor |
-
1985
- 1985-08-06 US US06/762,998 patent/US4686224A/en not_active Expired - Lifetime
- 1985-10-28 IL IL76854A patent/IL76854A/xx not_active IP Right Cessation
- 1985-10-29 PT PT81393A patent/PT81393B/pt not_active IP Right Cessation
- 1985-10-29 PL PL1985262327A patent/PL150842B1/pl unknown
- 1985-10-29 DE DE8585307794T patent/DE3585719D1/de not_active Expired - Lifetime
- 1985-10-29 EP EP85307794A patent/EP0181136B1/en not_active Expired - Lifetime
- 1985-10-29 PL PL1985255990A patent/PL145239B1/pl unknown
- 1985-10-30 KR KR1019850008037A patent/KR870001269B1/ko not_active Expired
- 1985-10-30 CA CA000494220A patent/CA1247099A/en not_active Expired
- 1985-10-30 HU HU854158A patent/HU194168B/hu not_active IP Right Cessation
- 1985-10-30 FI FI854258A patent/FI81340C/fi not_active IP Right Cessation
- 1985-10-30 DK DK497685A patent/DK163990C/da active
- 1985-10-30 AU AU49189/85A patent/AU555051B2/en not_active Ceased
- 1985-10-31 PH PH33000A patent/PH20985A/en unknown
- 1985-10-31 GR GR852629A patent/GR852629B/el unknown
- 1985-11-01 IE IE270385A patent/IE58207B1/en not_active IP Right Cessation
-
1986
- 1986-04-30 ES ES554609A patent/ES8707731A1/es not_active Expired
- 1986-12-05 PH PH34562A patent/PH23130A/en unknown
- 1986-12-05 PH PH34563A patent/PH24091A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK497685D0 (da) | 1985-10-30 |
| FI81340C (fi) | 1990-10-10 |
| PH20985A (en) | 1987-06-18 |
| KR860003260A (ko) | 1986-05-21 |
| AU555051B2 (en) | 1986-09-11 |
| IL76854A (en) | 1989-05-15 |
| ES8707731A1 (es) | 1987-08-16 |
| HUT39428A (en) | 1986-09-29 |
| KR870001269B1 (ko) | 1987-06-30 |
| EP0181136B1 (en) | 1992-03-25 |
| DK497685A (da) | 1986-05-01 |
| IE58207B1 (en) | 1993-07-28 |
| FI81340B (fi) | 1990-06-29 |
| EP0181136A2 (en) | 1986-05-14 |
| FI854258L (fi) | 1986-05-01 |
| PT81393A (en) | 1985-11-01 |
| GR852629B (pt) | 1986-03-04 |
| DK163990C (da) | 1992-09-21 |
| PH23130A (en) | 1989-05-05 |
| AU4918985A (en) | 1986-05-08 |
| IL76854A0 (en) | 1986-02-28 |
| HU194168B (en) | 1988-01-28 |
| PH24091A (en) | 1990-03-05 |
| PL262327A1 (en) | 1987-11-02 |
| ES554609A0 (es) | 1987-08-16 |
| PL145239B1 (en) | 1988-08-31 |
| DE3585719D1 (de) | 1992-04-30 |
| PL255990A1 (en) | 1987-03-23 |
| EP0181136A3 (en) | 1987-10-28 |
| IE852703L (en) | 1986-04-30 |
| FI854258A0 (fi) | 1985-10-30 |
| US4686224A (en) | 1987-08-11 |
| PL150842B1 (en) | 1990-07-31 |
| DK163990B (da) | 1992-04-27 |
| CA1247099A (en) | 1988-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20000229 |