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KR20210148232A - 조작된 캡시드를 갖는 아데노-연관 바이러스 - Google Patents

조작된 캡시드를 갖는 아데노-연관 바이러스 Download PDF

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KR20210148232A
KR20210148232A KR1020217035010A KR20217035010A KR20210148232A KR 20210148232 A KR20210148232 A KR 20210148232A KR 1020217035010 A KR1020217035010 A KR 1020217035010A KR 20217035010 A KR20217035010 A KR 20217035010A KR 20210148232 A KR20210148232 A KR 20210148232A
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크리스토퍼 에이. 레이드
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테나야 테라퓨틱스, 인코포레이티드
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Abstract

본 개시는, 고처리량 서열분석 스크린 또는 합리적 디자인을 사용하여 동정된 조작된 캡시드 단백질을 갖는 재조합 아데노-연관 바이러스(rAAV) 비리온을 제공한다. 특히, 본 개시는, 심장 세포에서 형질도입 효율의 증가, 세포 유형 선택성의 증가, 및/또는 다른 바람직한 특성을 갖는 AAV5 비리온 및 캡시드 단백질을 제공한다.

Description

조작된 캡시드를 갖는 아데노-연관 바이러스
본 개시는, 일반적으로 아데노-연관 바이러스 벡터를 사용한 유전자 요법에 관한 것이다. 특히, 본 개시는 조작된(engineered) 캡시드 단백질(capsid protein)을 갖는 재조합 아데노-연관 바이러스(recombinant adeno-associated virus) 비리온(virion)에 관한 것이다.
관련 출원에 대한 상호 참조
본 출원은, 2020년 3월 2일에 출원된 미국 가출원 번호 제62/984,197호 및 2019년 4월 1일에 출원된 미국 가출원 번호 제62/827,576호에 대한 우선권의 이익을 주장하고, 이들의 개시는 모든 목적을 위해 그 전체가 참조로 도입된다.
서열 목록에 대한 참조
이 출원은 EFS-Web을 통해 전자적으로 제출되고, 전자적으로 제출된 서열 목록이 .txt 형식으로 포함되어 있다. .txt 파일에는 2020년 3월 31일에 작성된 크기 약 2,590킬로바이트의 "TENA_012_02WO_SeqList_ST25.txt"라는 제목의 서열 목록이 포함되어 있다. 이 .txt 파일에 포함된 서열 목록은 본 명세서의 일부이고, 참조에 의해 그 전체가 본원에 도입된다.
아데노-연관 바이러스(AAV)는 유전자 치료 및 기타 생의학 응용 분야에 유망하다. 특히, AAV는 시험관내 및 생체내 모두에서 다양한 조직 및 세포에 유전자 산물(gene product)을 전달하기 위해 사용될 수 있다. AAV의 캡시드 단백질은 주로 AAV 벡터의 면역원성과 향성을 결정한다.
일부 조직의 경우, AAV 서브타입 5(AAV5)는, 인간 집단(population)에서 AAV5에 대한 중화 항체의 유병률이 낮기 때문에, 바람직한 AAV 벡터이다. 그러나, AAV5는 다른 AAV 서브타입보다 심장 조직을 덜 효과적으로 형질도입(transducing)한다. 또한, 상이한 세포 유형의 선택적 형질도입이 바람직하지만, 달성하는 것은 어렵다. 예를 들면, 일부 용도에서, 심근 세포가 아닌 심장 섬유아세포의 형질도입이 또는 그 반대가 바람직할 수 있다. 본 개시는, 야생형 AAV5 캡시드 단백질을 포함하는 rAAV 비리온보다 더욱 효율적으로 및/또는 보다 높은 선택성으로 심장 조직 및/또는 세포 유형을 형질도입할 수 있는 rAAV 비리온을 형성하는 AAV5 캡시드의 변이체를 제공한다.
하나의 측면에서, 본 개시는, AAV5 캡시드 단백질을 포함하는 재조합 아데노-연관 바이러스(rAAV) 비리온을 제공하고, 여기서 캡시드 단백질은, 모(parental) AAV5 캡시드와 비교하여, S651A, S651G, S651V, S651L, S651I, T578A, T578G, T578V, T578L, T578I, T582A, T582G, T582V, T582L, 또는 T582I로부터 선택된 하나 이상의 치환; 및 유전자 산물을 암호화(encoding)하는 뉴클레오티드 서열을 포함하는 이종 핵산을 포함한다.
또 다른 측면에서, 본 개시는, 모 AAV5 캡시드와 비교하여, S651A 또는 S651V; T578A 또는 T578V; 또는 T582A 또는 T582V로부터 선택된 하나 이상의 치환을 포함하는 AAV5 캡시드 단백질을 제공한다.
또 다른 측면에서, 본 개시는, AAV5 캡시드 단백질을 포함하는 재조합 아데노-연관 바이러스(rAAV) 비리온을 제공하고, 여기서 캡시드 단백질은 모 서열의 GH 루프(loop)의 삽입 부위에서 5 내지 11개 아미노산의 모 서열에 대한 삽입; 및 유전자 산물을 암호화하는 뉴클레오티드 서열을 포함하는 이종 핵산을 포함한다.
또 다른 측면에서, 본 개시는, AAV5 캡시드 단백질을 제공하고, 여기서 캡시드 단백질은 모 서열의 GH 루프 내의 삽입 부위에서 5 내지 11개 아미노산의 모 서열에 대한 삽입을 포함한다.
추가 측면에서, 본 개시는, AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 캡시드 단백질은 모 서열의 GH 루프 내의 삽입 부위에서 5 내지 11개 아미노산의 모 서열에 대한 삽입을 포함한다.
추가 측면에서, 본 개시는, AAV5 캡시드 단백질을 포함하는 rAAV 비리온을 포함하는 약제학적 조성물을 제공하고, 여기서 캡시드 단백질은 모 서열의 GH 루프의 삽입 부위에서 5 내지 11개 아미노산의 모 서열에 대한 삽입; 및 유전자 산물을 암호화하는 뉴클레오티드 서열을 포함하는 이종 핵산을 포함한다.
추가 측면에서, 본 개시는, 심장 세포(cardiac cell)를 본 개시의 rAAV 비리온과 접촉시키는 것을 포함하는, 심장 세포를 형질도입하는 방법을 제공하고, 여기서 rAAV 비리온은 심장 세포를 형질도입한다.
추가 측면에서, 본 개시는, 심장 세포를 본 개시의 rAAV 비리온과 접촉시키는 것을 포함하는, 하나 이상의 유전자 산물을 심장 세포에 전달하는 방법을 제공하고, 여기서 심장 세포는 유전자 산물을 발현한다.
추가 측면에서, 본 개시는, 본 개시의 rAAV 비리온을 포함하는 치료학적 유효량의 약제학적 조성물을 투여하는 것을 포함하는, 이를 필요로 하는 대상체(subject)에서 심장 병리(cardiac pathology)를 치료하는 방법을 제공하고, 여기서 rAAV 비리온은 심장 조직을 형질도입한다.
추가 측면에서, 본 개시는, 표적 세포에서 형질도입 효율의 증가를 rAAV 비리온에 부여하는 AAV 캡시드 단백질을 동정(identifying)하는 방법을 제공하고, 이는, 이의 rAAV 게놈이 변이체 AAV 캡시드 단백질을 암호화하는 cap 뉴클레오티드의 라이브러리를 포함하는 rAAV 비리온의 집단을 제공하는 단계; rAAV 비리온에 의해 표적 세포 내로 cap 폴리뉴클레오티드의 형질도입을 허용하기에 충분한 시간 동안 집단을 표적 세포와 접촉시키는 단계; 및 표적 세포로부터 cap 폴리뉴클레오티드를 서열분석(sequencing)하고, 이에 의해 표적 세포에서 형질도입 효율의 증가를 부여하는 AAV 캡시드 단백질을 동정하는 단계를 포함한다.
도 1은 유도 만능 줄기 세포-유래 심근세포(iPSC-CM)에 대한 초기 음성 선택 단계, 이어서 인간 심장 섬유아세포(hCF)에 대한 양성 선택 단계를 도입하는 라이브러리 스크리닝 전략의 실시양태를 나타낸다.
도 2A-2B는 AAV5 랜덤 펩티드 디스플레이 라이브러리의 생성 및 AAV5의 결정 구조에 대한 맵핑을 도시한다. 도 2A는 3' 및 5' 역방향 말단 반복서열(ITR)이 인접하는 AAV2의 rep 유전자("Rep2") 및 AAV의 cap 유전자("Cap5")를 포함하는 AAV 게놈의 개략도를 나타낸다. 이 실시양태에서, 알라닌 잔기(AXXXXXXXA; 서열번호 100)에 인접하는 랜덤 7량체 폴리펩티드 라이브러리는 표시된 바와 같이 위치 575에 삽입된다. 도 2B는 AAV5 캡시드의 구조를 나타낸다. 폴리펩티드 라이브러리의 대략적 삽입 위치(표시된 캡시드 단백질의 60개 카피 중 하나)는 흑색 화살표로 표시된다.
도 3A-3D는 스크리닝의 각 라운드 후의 라이브러리 복잡성을 시각화하고, 총 판독 수 및 고유한 펩티드인 판독 백분율을 보고한다. 각 변이체는 펩티드 서열의 소수성에 기초하여 상이한 회색 음영으로 표시되고, 이미지의 각 픽셀은 라이브러리 내의 단일 판독을 나타내고, 동일한 서열의 다른 판독과 클러스터링된다. 농후화의 증가는, 라운드 1(도 3B) 후, 라운드 2(도 3C) 후, 또는 라운드 3(도 3D) 후의 모 라이브러리(도 3A)와 비교하여 판독의 과잉(즉, 고유 펩티드인 판독의 백분율의 감소)에 기초하여 명백하다.
도 4A-4D는 라이브러리 스크리닝 전략을 사용하여 동정된 다양한 rAAV 비리온의 hCF 세포에 대한 형질도입 효율을 나타낸다. 도 4A는 녹색 형광 단백질(GFP) 리포터 도입유전자를 패키징하는 비변형 AAV5(가장 우측 바)에 대해 벤치마킹된 15개의 AAV5 변이체의 형질도입 효율을 나타낸다. hCF는 100,000의 게놈 감염 다중도(MOI)에서 감염되었고, GFP 양성 세포의 백분율은 Cytation 5™ 세포 이미징 다중 모드 판독기를 사용하여 정량화되었다. 비변형 AAV5(도 4B) 또는 AAV5.CR17(도 4C) 중 어느 하나에 의해 형질도입된 hCF에 대한 대표적 형광 이미지가 제시된다. 도 4D는 1,000의 MOI에서 AAV.CR17에 대한 비변형 AAV5의 형질도입 효율을 나타낸다.
도 5A-5D는 라이브러리 스크리닝 전략을 사용하여 동정된 다양한 rAAV 비리온의 iPS-CM 세포에 대한 형질도입 효율을 나타낸다. 도 5A는 GFP 리포터 도입유전자를 패키징하는 비변형 AAV5(가장 우측 바)에 대해 벤치마킹된 15개의 AAV5 변이체의 형질도입 효율을 나타낸다. hCF는 100,000의 게놈 감염 다중도(MOI)에서 감염되었고, GFP 양성 세포의 백분율은 Cytation 5™ 세포 이미징 다중 모드 판독기를 사용하여 정량화되었다. 비변형된 AAV5(도 5B) 또는 AAV5.CR23(도 5C) 중 어느 하나에 의해 형질도입된 hCF에 대한 대표적 형광 이미지가 제시된다. 도 5D는 100,000의 MOI에서 AAV.CR23에 대한 비변형 AAV5의 형질도입 효율을 나타낸다.
도 6A-6E는 AAV5.CR17이 1차 마우스 심장 섬유아세포(mCF)에서 형질도입 효율을 개선시키는 것을 입증한다. mCF는 높은(100,000), 중간(10,000) 또는 낮은(1,000) MOI에서 AAV5.CAG-GFP 또는 AAV5.CR17.CAG-GFP 중 어느 하나로 감염되었다. 감염 72시간 후, 유세포 분석을 사용하여 형질도입을 평가했다. 도 6A는 "총 GFP" 및 "높은 GFP" 집단의 히스토그램 및 게이팅을 나타낸다. 세포가 AAV5.CR17로 형질도입된 경우, MOI가 103, 104, 또는 105인 비변형 AAV5와 비교하여, "총 GFP" 집단에서 증가된 백분율 GFP+(도 6B) 및 GFP 강도(도 6C)가 관찰되었다. 세포가 AAV5.CF17로 형질도입된 경우, MOI가 103, 104 또는 105인 비변형 AAV5와 비교하여, "높은 GFP" 집단에서 증가된 백분율 GFP+(도 6D) 및 GFP 강도(도 6E)가 관찰되었다.
도 7A-7H는 심근경색증(MI)을 수반하거나 수반하지 않는 CD1 마우스에서 AAV5 및 AAV5.CR17의 형질도입 프로파일을 나타낸다. 비변형 AAV5는 대조군 마우스(GFP - 도 7A; DAPI - 도 7B) 또는 유도된 MI 마우스(GFP - 도 7C; DAPI - 도 7D)에서 심장 조직의 제한된 형질도입을 나타냈다. AAV5.CR17은 대조군 마우스(GFP - 도 7E; DAPI - 도 7F) 및 유도된 MI 마우스(GFP - 도 7G; DAPI - 도 7H) 모두에서 심장 조직을 보다 효과적으로 형질도입했다. 1.2×1011vg의 AAV5.CAG-GFP 또는 AAV5.CR17.CAG-GFP 중 어느 하나를 심근내 주사에 의해 6주령 CD1 마우스에게 주사했다. GFP 강도 및 분포는 주사 후 7일에 평가되었다. 비-MI 및 MI 동물 모두에서, AAV5.CR17로 심근세포 및 섬유아세포 형질도입의 증가가 관찰된다. 모든 심장 조직 섹션은 동일한 획득 및 노출로 20배 대물렌즈를 사용하여 이미지화되었다. 항-GFP 면역염색은 녹색으로 제시되고, DAPI 청색을 사용한 핵 대조염색은 청색으로 제시된다.
도 8A-8E는 표 2(서열번호 101-600)의 상위 100개(도 8A), 상위 50개(도 8B), 상위 20개(도 8C)의 서열, 또는 표 1(도 8D)에 보고된 데이터를 갖는 서열(서열번호 101-115)에 기초한 서열 모티프(motif)를 나타낸다. 도 8E는 라운드 3 후의 라이브러리 내의 서열 판독 수에 의해 가중된 라이브러리 내의 모든 서열 판독에 대한 서열 모티프를 나타낸다(서열번호 101-600).
도 9는 AAV5 표면-노출된 세린/트레오닌/리신/티로신 돌연변이체 벡터가 시험관내 hCF의 형질도입 효율의 증가를 입증하는 것을 나타낸다. hCF 세포는 편재적으로 발현되는 GFP 리포터를 패키징하는 AAV5-wt 또는 AAV5-돌연변이 벡터 중 어느 하나로 감염되었다. AAV5 캡시드의 치환 S651A, T578A 또는 T582A는 감염 72시간 후의 감염 다중도 100,000 vg/세포에서 인간 심장 섬유아세포 형질도입을 개선시켰다.
도 10A-10C는 AAVx1 벡터(상부 라인) 또는 AAV5 벡터(하부 라인) 중 어느 하나에 의한 인간 심장 섬유아세포(hCF)의 형질도입을 나타낸다. 도 10A는 형질도입된 세포의 백분율을 나타낸다. 도 10B는 GFP 도입유전자 발현을 나타낸다. 도 10C는 상대적 형질도입을 나타낸다(상대적 형질도입 = 형질도입된 세포(%) × 세포 강도).
도 11은 생체내에서 심장 섬유아세포(CF) 세포의 상대적 형질도입을 나타낸다.
도 12는 % 구출률의 동적 심장초음파 데이터에 의해, MyA 발현 카세트를 갖는 AAVx1 벡터가 심근경색증에 대해 효과적인 것을 나타낸다.
도 13은 주사 후 9주까지, 허혈성 손상을 갖는 치료된 돼지와 치료되지 않은 돼지의 구출률 변화의 그래프를 나타낸다.
본 개시는, 일반적으로, (1) 선택된 표면-노출된 아미노산 잔기에서의 치환; (2) GH 루프에 삽입; 또는 (3) 이들 둘 다를 갖는 캡시드 단백질을 갖는 바이러스 벡터로서 사용하기 위한 재조합 아데노-연관 바이러스(rAAV) 비리온에 관한 것이다. rAAV 비리온은 심장 조직, 예를 들면, 심장 섬유아세포를, 적어도 이러한 치환 및/또는 삽입이 없는 모 캡시드 단백질을 갖는 rAAV 비리온보다 동등 또는 우수하게 형질도입할 수 있다.
본 개시는, 재조합 아데노-연관 바이러스(rAAV) 비리온을 제공한다. 특히, 본 개시는, 신규 캡시드 단백질, 이를 동정하는 방법, 및 이를 사용하는 방법을 제공한다. 본원에 개시된 신규한 캡시드 단백질을 동정하는 방법은, 하이브리드 캡시드 단백질을 포함하는 AAV의 임의의 혈청형에 대해 광범위하게 적용할 수 있다. 또한, 이들은 이 방법 또는 다른 방법으로부터 돌연변이를 갖는 캡시드 단백질을 반복적으로 개선하기 위해 적용할 수 있다. 일반적으로, 본 개시의 방법은, cap 유전자 폴리뉴클레오티드 형태의 AAV 캡시드의 랜덤화 또는 세미-랜덤화 라이브러리의 제조, AAV 비리온을 양성 또는 음성으로 선택하고 서열분석을 위해 cap 유전자를 회수하는, 이러한 캡시드를 포함하는 AAV 비리온의 제조(cap 유전자 라이브러리를 AAV 게놈에 도입하거나, 패키징 라인으로 형질감염된 플라스미드 등으로 이를 트랜스 제공함으로써)에 관한 것이다. 일부 실시양태에서, 회수 및 서열분석은 나노포어 서열분석을 포함한다. 기타 고처리량 또는 차세대 서열분석(NGS) 방법을 사용할 수 있다.
일부 실시양태에서, 본원에 개시된 rAAV 비리온은 AAV5 캡시드 단백질을 포함하고, 여기서 캡시드 단백질은 모 서열의 GH 루프 내의 삽입 부위에서 5 내지 11개 아미노산의 모 서열에 대한 삽입을 포함한다. rAAV 비리온은 일반적으로 유전자 산물을 암호화하는 뉴클레오티드 서열을 포함하는 이종 핵산을 포함한다. 삽입에 적합한 삽입 부위는, AAV5 캡시드의 결정 구조에 기초한 GH 루프 모델링을 포함하지만 이들로 한정되지 않는 다양한 방법에 의해; 유연한 잔기를 선택함으로써; 또는 다양한 삽입 부위를 스크리닝함으로써 결정될 수 있다. 삽입은 2개의 인접한 아미노산 잔기 사이에 있을 수 있거나, 인접하지 않은 잔기가 선택될 수 있고, 이 경우, 삽입은 하나 이상의 개재 잔기의 결실을 야기한다.
일부 실시양태에서, AAV5 캡시드 단백질은, 합리적으로 설계되거나; 돌연변이 유발에 의해 도입되거나; 또는 하나 이상의 부위에서 랜덤 코돈 사용을 갖는 서열의 라이브러리를 생성함으로써 랜덤화되는, 잔기의 치환을 포함한다. 형질감염 효율에 영향을 미치는 예시적인 비제한적 치환은 S651A, T578A 또는 T582A를 포함하나 이들로 한정되지 않는다. 치환된 잔기는, 하나 이상의 삽입 부위, 예를 들면, GH 루프 또는 다른 루프에서 삽입을 추가로 포함하는 AAV5 캡시드 단백질 내로 도입될 수 있다.
본 개시의 캡시드 단백질은, 실시예에 나타낸 바와 같이(그러나, 이들로 한정되지는 않음), 유도 진화, 및 이어서 서열에 의해 농후화된 것으로 동정된 임의의 삽입을 포함한다. 임의의 특정 삽입 부위로 한정되지 않고, 일부 실시양태에서, 삽입은 AAV5 캡시드 단백질(서열번호 1)의 약 잔기 574 내지 575 사이이다. 일부 실시양태에서, 삽입 부위는 서열번호 1의 560 내지 594에 대응하는 모 서열의 위치에서 임의의 2개의, 임의로 인접한 아미노산 사이에 있다. 일부 실시양태에서, 삽입 부위는, 서열번호 1의 574 및 575에 대응하는 모 서열에서 인접한 아미노산 사이에 있다. VP1, VP2 및 VP3의 N-말단 잔기는 전장 VP1의 서열 위에 표시된다.
VP1-->
M SFVDHPPDWLEEVGEGLREFLGLEAGPPKPKPNQQHQDQARGLVLPGYNYLGPGNGLDRGEPVNRADEVAREHDISYNEQLEAGDNPYLKYNHADAEFQEKLADDTSFGGNLGKAVFQAKKRVLE
VP2-->
PFGLVEEGAK T APTGKRIDDHFPKRKKARTEEDSKPSTSSDAEAGPSGSQQLQIPAQPASSLG
VP3-->
ADTMSAGGGGPLGDNNQGADGVGNASGDWHCDSTW M GDRVVTKSTRTWVLPSYNNHQYREIKSGSVDGSNANAYFGYSTPWGYFDFNRFHSHWSPRDWQRLINNYWGFRPRSLRVKIFNIQVKEVTVQDSTTTIANNLTSTVQVFTDDDYQLPYVVGNGTEGCLPAFPPQVFTLPQYGYATLNRDNTENPTERSSFFCLEYFPSKMLRTGNNFEFTYNFEEVPFHSSFAPSQNLFKLANPLVDQYLYRFVSTNNTGGVQFNKNLAGRYANTYKNWFPGPMGRTQGWNLGSGVNRASVSAFATTNRMELEGASYQVPPQPNGMTNNLQGSNTYALENTMIFNSQPANPGTTATYLEGNMLITSESETQPVNRVAYNVG
↓ 삽입 부위 575
GQMATNNQ_SSTTAPATGTYNLQEIVPGSVWMERDVYLQGPIWAKIPETGAHFHPSPAMGGFGLKHPPPMMLIKNTPVPGNITSFSDVPVSSFITQYSTGQVTVEMEWELKKENSKRWNPEIQYTNNYNDPQFVDFAPDSTGEYRTTRPIGTRYLTRPL
(서열번호 1)
이 삽입 부위에서의 삽입은 VP3 캡시드 단백질을, 명확성을 위해 본원에서 별개의 서열로 개시된 N-말단 세그먼트(서열번호 2)과 C-말단 세그먼트(서열번호 3)로 분할하고, 이는 본 개시의 임의의 삽입에 의해 연결될 수 있다. 일부 실시양태에서, 캡시드 단백질은 서열 1과 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 또는 100% 동일한 서열을 포함한다(명확성을 위해, 삽입 부위의 정렬에 갭이 있음). 일부 실시양태에서, 캡시드 단백질은, 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 또는 100% 동일성(identity)을 공유하고 서열번호 3과 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일성을 공유하는 서열을 포함하고, 여기서 서열번호 2 및 서열번호 3은 5 내지 11개의 아미노산의 삽입에 의해 연결된다. 일부 실시양태에서, 삽입은 서열번호 101-600으로부터 선택된다. 일부 실시양태에서, 서열번호 101-600의 인접 알라닌(A) 잔기는, 유연한 잔기 세린(S) 또는 글리신(G) 등의 다른 잔기로 치환되고, 인접 A 잔기는 존재하지 않는다.
MGDRVVTKSTRTWVLPSYNNHQYREIKSGSVDGSNANAYFGYSTPWGYFDFNRFHSHWSPRDWQRLINNYWGFRPRSLRVKIFNIQVKEVTVQDSTTTIANNLTSTVQVFTDDDYQLPYVVGNGTEGCLPAFPPQVFTLPQYGYATLNRDNTENPTERSSFFCLEYFPSKMLRTGNNFEFTYNFEEVPFHSSFAPSQNLFKLANPLVDQYLYRFVSTNNTGGVQFNKNLAGRYANTYKNWFPGPMGRTQGWNLGSGVNRASVSAFATTNRMELEGASYQVPPQPNGMTNNLQGSNTYALENTMIFNSQPANPGTTATYLEGNMLITSESETQPVNRVAYNVGGQMATNNQ
(서열번호 2)
SSTTAPATGTYNLQEIVPGSVWMERDVYLQGPIWAKIPETGAHFHPSPAMGGFGLKHPPPMMLIKNTPVPGNITSFSDVPVSSFITQYSTGQVTVEMEWELKKENSKRWNPEIQYTNNYNDPQFVDFAPDSTGEYRTTRPIGTRYLTRPL
(서열번호 3)
일부 실시양태에서, 캡시드 단백질은, 서열번호 4와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 또는 100% 동일한 서열을 포함하고, 여기서 X는 임의의 아미노산을 나타낸다. 일부 실시양태에서, 캡시드 단백질은, 서열번호 5와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 또는 100% 동일한 서열을 포함하고, 여기서 X는 임의의 아미노산을 나타낸다.
MGDRVVTKSTRTWVLPSYNNHQYREIKSGSVDGSNANAYFGYSTPWGYFDFNRFHSHWSPRDWQRLINNYWGFRPRSLRVKIFNIQVKEVTVQDSTTTIANNLTSTVQVFTDDDYQLPYVVGNGTEGCLPAFPPQVFTLPQYGYATLNRDNTENPTERSSFFCLEYFPSKMLRTGNNFEFTYNFEEVPFHSSFAPSQNLFKLANPLVDQYLYRFVSTNNTGGVQFNKNLAGRYANTYKNWFPGPMGRTQGWNLGSGVNRASVSAFATTNRMELEGASYQVPPQPNGMTNNLQGSNTYALENTMIFNSQPANPGTTATYLEGNMLITSESETQPVNRVAYNVGGQMATNNQ XXXXXXXXX SSTTAPATGTYNLQEIVPGSVWMERDVYLQGPIWAKIPETGAHFHPSPAMGGFGLKHPPPMMLIKNTPVPGNITSFSDVPVSSFITQYSTGQVTVEMEWELKKENSKRWNPEIQYTNNYNDPQFVDFAPDSTGEYRTTRPIGTRYLTRPL
(서열번호 4)
MGDRVVTKSTRTWVLPSYNNHQYREIKSGSVDGSNANAYFGYSTPWGYFDFNRFHSHWSPRDWQRLINNYWGFRPRSLRVKIFNIQVKEVTVQDSTTTIANNLTSTVQVFTDDDYQLPYVVGNGTEGCLPAFPPQVFTLPQYGYATLNRDNTENPTERSSFFCLEYFPSKMLRTGNNFEFTYNFEEVPFHSSFAPSQNLFKLANPLVDQYLYRFVSTNNTGGVQFNKNLAGRYANTYKNWFPGPMGRTQGWNLGSGVNRASVSAFATTNRMELEGASYQVPPQPNGMTNNLQGSNTYALENTMIFNSQPANPGTTATYLEGNMLITSESETQPVNRVAYNVGGQMATNNQ AXXXXXXXA SSTTAPATGTYNLQEIVPGSVWMERDVYLQGPIWAKIPETGAHFHPSPAMGGFGLKHPPPMMLIKNTPVPGNITSFSDVPVSSFITQYSTGQVTVEMEWELKKENSKRWNPEIQYTNNYNDPQFVDFAPDSTGEYRTTRPIGTRYLTRPL
(서열번호 5)
일부 실시양태에서, 삽입은 하기 식의 펩티드이다:
-X0-(X)n-X10-
상기 식에서, n은 5-9이고, X0 및 X10은 각각 독립적으로 A, S, G이거나, 부재한다(서열번호 1101).
일부 실시양태에서, 삽입은 하기 식의 펩티드이다:
-X0-X1-X2-X3-X4-X5-X6-X7-X8-
상기 식에서, X0 및 X8은 각각 독립적으로 A, S, G이거나, 부재한다(서열번호 1102).
일부 실시양태에서, 삽입은 하기 식의 펩티드이다:
-A-X1-X2-X3-X4-X5-X6-X7-A-
상기 식에서, X1은 P, R 또는 G이고; X2는 K, L 또는 R이고; X3은 임의의 아미노산이고; X4는 N, H, K 또는 Q이고; X5는 임의의 아미노산이거나, 임의로 X5는 G, K 또는 S이고; X6은 임의의 아미노산이거나, 임의로 X6은 T 또는 V이고; X7은 임의의 아미노산이거나, 임의로 X7은 K 또는 V이다(서열번호 1103).
일부 실시양태에서, 삽입은 하기 식의 펩티드이다:
-A-X1-X2-X3-X4-X5-X6-X7-A-
상기 식에서, X1은 P, R 또는 G이고; X2는 K, L 또는 R이고; X3은 임의의 아미노산이고; X4는 N, H, K 또는 Q이고; X5는 임의의 아미노산이거나, 임의로 X5는 G, K 또는 S이고; X6은 임의의 아미노산이고; X7은 임의의 아미노산이다(서열번호 1104).
일부 실시양태에서, 삽입은 하기 식의 펩티드이다:
-A-X1-X2-X3-X4-X5-X6-X7-A-
상기 식에서, X1은 P, R 또는 G이고; X2는 K, L 또는 R이고; X3은 임의의 아미노산이고; X4는 N, H, K 또는 Q이고; X5는 임의의 아미노산이거나, 임의로 X5는 G, K 또는 S이고; X6은 T 또는 V이고; X7은 임의의 아미노산이다(서열번호 1105).
일부 실시양태에서, 삽입은 하기 식의 펩티드이다:
-A-X1-X2-X3-X4-X5-X6-X7-A-
상기 식에서, X1은 P, R 또는 G이고; X2는 K, L 또는 R이고; X3은 임의의 아미노산이고; X4는 N, H, K 또는 Q이고; X5는 임의의 아미노산이거나, 임의로 X5는 G, K 또는 S이고; X6은 T 또는 V이고; X7은 K 또는 V이다(서열번호 1106).
일부 실시양태에서, X1 내지 X7은 임의의 아미노산이고, 여기서 삽입은 하기 기준 중 하나 이상에 의해 정의된다: X1은 P, R, 또는 G이고; X2는 K, L 또는 R이고; X3은 임의의 아미노산이고; X4는 N, H, K 또는 Q이고; X5는 G, K 또는 S이고; X6은 T 또는 V이고; 및/또는 X7은 K 또는 V이다(서열번호 1107).
일부 실시양태에서, 삽입은 서열번호 101-600으로부터 선택된다.
일부 실시양태에서, 캡시드 단백질은, N-말단으로부터 C-말단 순서로, 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일하고 서열번호 3과 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일한 서열을 갖는 하나의 폴리펩티드; 101-600으로부터 선택된 하나의 폴리펩티드; 및 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 또는 100% 동일하고 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일한 서열을 갖는 하나의 폴리펩티드를 포함한다.
일부 실시양태에서, 캡시드 단백질은, N-말단으로부터 C-말단 순서로, 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일하고 서열번호 3과 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일한 서열을 갖는 하나의 폴리펩티드; 서열번호 101-200으로부터 선택된 하나의 폴리펩티드; 및 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 또는 100% 동일하고 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일한 서열을 갖는 하나의 폴리펩티드를 포함한다.
일부 실시양태에서, 캡시드 단백질은, N-말단으로부터 C-말단 순서로, 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일하고 서열번호 3과 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일한 서열을 갖는 하나의 폴리펩티드; 서열번호 101-150으로부터 선택된 하나의 폴리펩티드; 및 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 또는 100% 동일하고 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일한 서열을 갖는 하나의 폴리펩티드를 포함한다.
일부 실시양태에서, 캡시드 단백질은, N-말단으로부터 C-말단 순서로, 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일하고 서열번호 3과 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일한 서열을 갖는 하나의 폴리펩티드; 서열번호 101-120으로부터 선택된 하나의 폴리펩티드; 및 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 또는 100% 동일하고 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일한 서열을 갖는 하나의 폴리펩티드를 포함한다.
일부 실시양태에서, 캡시드 단백질은, N-말단으로부터 C-말단 순서로, 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일하고 서열번호 3과 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일한 서열을 갖는 하나의 폴리펩티드; 서열번호 101-115로부터 선택된 하나의 폴리펩티드; 및 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 또는 100% 동일하고 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일한 서열을 갖는 하나의 폴리펩티드를 포함한다.
일부 실시양태에서, 캡시드 단백질은, N-말단으로부터 C-말단 순서로, 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일하고 서열번호 3과 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일한 서열을 갖는 하나의 폴리펩티드; 서열번호 103 또는 110으로부터 선택된 하나의 폴리펩티드; 및 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 또는 100% 동일하고 서열번호 2와 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% 또는 100% 동일한 서열을 갖는 하나의 폴리펩티드를 포함한다.
일부 실시양태에서, 캡시드 단백질은, 서열번호 601-1100 중 하나 또는 이의 기능적 단편과 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 또는 100% 동일한 서열을 갖는 폴리펩티드를 포함하거나, 실질적으로 이들로 이루어지거나, 이들로 이루어진다.
일부 실시양태에서, 캡시드 단백질은, 서열번호 601-615 중 하나 또는 이의 기능적 단편과 적어도 약 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 또는 100% 동일한 서열을 갖는 폴리펩티드를 포함하거나, 실질적으로 이들로 이루어지거나, 이들로 이루어진다.
일부 실시양태에서, 삽입은 RKVHIEV(서열번호 81), RKYQSDL(서열번호 82), PLTNTVK(서열번호 83), LKYHGPP(서열번호 84), RKYQGDM(서열번호 85), RKFHSTD(서열번호 86), RKHHGLE(서열번호 87), PGTNVTK(서열번호 88), RKMHMPD(서열번호 89), PLKKIVQ(서열번호 90), PLGKKTS(서열번호 91), PRGVKVT(서열번호 92), PLAKSKS(서열번호 93), PRTKGAV(서열번호 94) 및 PSGRKAT(서열번호 95)로부터 선택된 아미노산 서열을 포함한다.
일부 실시양태에서, 삽입은 ARKVHIEVA(서열번호 101), ARKYQSDLA(서열번호 102), APLTNTVKA(서열번호 103), ALKYHGPPA(서열번호 104), ARKYQGDMA(서열번호 105), ARKFHSTDA(서열번호 106), ARKHHGLEA(서열번호 107), APGTNVTKA(서열번호 108), ARKMHMPDA(서열번호 109), APLKKIVQA(서열번호 110), APLGKKTSA(서열번호 111), APRGVKVTA(서열번호 112), APLAKSKSA(서열번호 113), APRTKGAVA(서열번호 114), APSGRKATA(서열번호 115)로부터 선택된 아미노산 서열을 포함한다.
일부 실시양태에서, 삽입은 서열번호 101-600 중 어느 하나를 포함한다. 일부 실시양태에서, 서열은 서열번호 101-600 중 어느 하나에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함한다.
일부 실시양태에서, 삽입은 아미노산 서열 PLTNTVK(서열번호 83){클론 CR17}, 또는 PLTNTVK(서열번호 83)에 대해 최대 1, 2, 3 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 삽입은 아미노산 서열 PLKKIVQ(서열번호 90){클론 CR23}, 또는 PLKKIVQ(서열번호 90)에 대해 최대 1, 2, 3 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 삽입은 아미노산 서열 APLTNTVKA(서열번호 103){클론 CR17}, 또는 APLTNTVKA(서열번호 103)에 대해 최대 1, 2, 3 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 삽입은 아미노산 서열 APLKKIVQA(서열 110){클론 CR23}을 포함하고, 여기서 삽입은 1, 2, 3 또는 4개의 보존적 아미노산 치환을 추가로 포함한다.
일부 실시양태에서, 삽입은 아미노산 서열 PLTNTVK(서열 83){클론 CR17}을 포함하고, 여기서 삽입은 1, 2, 3 또는 4개의 보존적 아미노산 치환을 추가로 포함한다.
일부 실시양태에서, 삽입은 아미노산 서열 PLKKIVQ(서열 90){클론 CR23}을 포함하고, 여기서 삽입은 1, 2, 3 또는 4개의 보존적 아미노산 치환을 추가로 포함한다.
일부 실시양태에서, 삽입은 아미노산 서열 APLTNTVKA(서열 103){클론 CR17}을 포함하고, 여기서 삽입은 1, 2, 3 또는 4개의 보존적 아미노산 치환을 추가로 포함한다.
일부 실시양태에서, 삽입은 적어도 아미노산 서열 APLKKIVQA(서열 110){클론 CR23}을 포함하고, 여기서 삽입은 1, 2, 3 또는 4개의 보존적 아미노산 치환을 추가로 포함한다.
보존적 치환에는, 극성 잔기의 경우는 극성, 비극성 잔기의 경우는 비극성, 소수성 잔기의 경우는 소수성, 작은 잔기의 경우는 작게, 큰 잔기의 경우는 크게 포함된다. 보존적 치환은 하기 그룹 내의 치환을 추가로 포함한다: {S, T}, {A, G}, {F, Y}, {R, H, K, N, E}, {S, T, N, Q}, {C, U, G, P; A} 및 {A, V, I, L, M, F, Y, W}.
형질도입 효율은 당해 기술분야에 공지된 방법 또는 실시예에 기재된 방법을 사용하여 결정할 수 있다. 일부 실시양태에서, rAAV 비리온은, 모 서열을 포함하는 AAV 비리온과 비교하여, 심장 세포에서 증가된 형질도입 효율을 나타낸다.
일부 실시양태에서, rAAV 비리온은, 모 서열을 포함하는 AAV 비리온과 비교하여, 인간 심장 섬유아세포(hCF) 세포에서 형질도입 효율의 증가를 나타낸다.
일부 실시양태에서, rAAV 비리온은, 100,000의 감염 다중도(MOI)에서 hCF 세포에서 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 또는 15배의 형질도입 효율의 증가를 나타낸다. 일부 실시양태에서, rAAV 비리온은, 감염 다중도(MOI) 100,000에서 hCF 세포에서 약 2 내지 약 16배, 약 2 내지 약 14배, 약 2 내지 약 12배, 약 2 내지 약 10배, 약 2 내지 약 8배, 약 2 내지 약 6배, 약 2 내지 약 4배, 또는 약 2 내지 약 3배의 형질도입 효율의 증가를 나타낸다. 일부 실시양태에서, rAAV 비리온은, 100,000의 감염 다중도(MOI)에서 hCF 세포에서 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 또는 15배의 형질도입 효율의 증가를 나타낸다. 일부 실시양태에서, rAAV 비리온은, 100,000의 감염 다중도(MOI)에서 hCF 세포에서 약 20% 내지 30%, 약 30% 내지 40%, 약 40% 내지 50%, 약 50% 내지 80%, 약 80% 내지 100%, 약 100% 내지 125%, 약 125% 내지 150%, 약 150% 내지 175%, 또는 약 175% 내지 200%의 형질도입 효율의 증가를 나타낸다.
일부 실시양태에서, rAAV 비리온은, 1,000의 감염 다중도(MOI)에서 hCF 세포에서 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 또는 15배의 형질도입 효율의 증가를 나타낸다. 일부 실시양태에서, rAAV 비리온은, 1,000의 감염 다중도(MOI)에서 hCF 세포에서 약 2 내지 약 16배, 약 2 내지 약 14배, 약 2 내지 약 12배, 약 2 내지 약 10배, 약 2 내지 약 8배, 약 2 내지 약 6배, 약 2 내지 약 4배, 또는 약 2 내지 약 3배의 형질도입 효율의 증가를 나타낸다. 일부 실시양태에서, rAAV 비리온은, 1,000의 감염 다중도(MOI)에서 hCF 세포에서 약 20% 내지 30%, 약 30% 내지 40%, 약 40% 내지 50%, 약 50% 내지 80%, 약 80% 내지 100%, 약 100% 내지 125%, 약 125% 내지 150%, 약 150% 내지 175%, 또는 약 175% 내지 200%의 형질도입 효율의 증가를 나타낸다.
일부 실시양태에서, rAAV 비리온은, 모 서열을 포함하는 AAV 비리온과 비교하여, 유도 만능 줄기 세포-유래 심근세포(iPS-CM) 세포에서 형질도입 효율의 증가를 나타낸다.
일부 실시양태에서, rAAV 비리온은, 100,000의 감염 다중도(MOI)에서 iPS-CM 세포에서 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 또는 15배의 형질도입 효율의 증가를 나타낸다. 일부 실시양태에서, rAAV 비리온은, 감염 다중도(MOI) 100,000에서 iPS-CM 세포에서 약 2 내지 약 16배, 약 2 내지 약 14배, 약 2 내지 약 12배, 약 2 내지 약 10배, 약 2 내지 약 8배, 약 2 내지 약 6배, 약 2 내지 약 4배, 또는 약 2 내지 약 3배의 형질도입 효율의 증가를 나타낸다. 일부 실시양태에서, rAAV 비리온은, 100,000의 감염 다중도(MOI)에서 iPS-CM 세포에서 약 20% 내지 30%, 약 30% 내지 40%, 약 40% 내지 50%, 약 50% 내지 80%, 약 80% 내지 100%, 약 100% 내지 125%, 약 125% 내지 150%, 약 150% 내지 175%, 또는 약 175% 내지 200%의 형질도입 효율의 증가를 나타낸다.
일부 실시양태에서, rAAV 비리온은 1,000의 감염 다중도(MOI)에서 iPS-CM 세포에서 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12-, 13, 14, 또는 15배의 형질도입 효율의 증가를 나타낸다. 일부 실시양태에서, rAAV 비리온은 감염 다중도(MOI) 1,000에서 iPS-CM 세포에서 약 2 내지 약 16배, 약 2 내지 약 14배, 약 2 내지 약 12배, 약 2 내지 약 10배, 약 2 내지 약 8배, 약 2 내지 약 6배, 약 2 내지 약 4배, 또는 약 2 내지 약 3배의 형질도입 효율의 증가를 나타낸다. 일부 실시양태에서, rAAV 비리온은 1,000의 감염 다중도(MOI)에서 iPS-CM 세포에서 약 20% 내지 30%, 약 30% 내지 40%, 약 40% 내지 50%, 약 50% 내지 80%, 약 80% 내지 100%, 약 100% 내지 125%, 약 125% 내지 150%, 약 150% 내지 175%, 또는 약 175% 내지 200%의 형질도입 효율의 증가를 나타낸다.
한 세포 유형의 형질도입 효율의 다른 세포 유형에 대한 비율이 모 서열과 비교하여 캡시드 단백질에 의해 증가되면, 세포 유형에 대한 선택성이 증가한다. 일부 실시양태에서, rAAV 비리온은 iPS-CM 세포보다도 hCF 세포에 대한 rAAV 비리온의 증가된 선택성을 나타낸다.
일부 실시양태에서, rAAV 비리온은 hCF 세포보다도 iPS-CM 세포에 대한 rAAV 비리온의 증가된 선택성을 나타낸다.
일부 실시양태에서, 캡시드 단백질은 S651A, T578A, T582A, K251R, Y709F, Y693F, 또는 S485A로부터 선택된 돌연변이를 포함한다. 일부 실시양태에서, 캡시드 단백질은 K251R, Y709F, Y693F, 또는 S485A로부터 선택된 돌연변이를 포함한다.
캡시드 단백질을 암호화하는 폴리뉴클레오티드는 야생형 cap 유전자의 본래(native)의 코돈, 또는 동일한 단백질을 암호화하도록 선택된 대체 코돈 중 어느 하나를 포함하는 서열을 포함할 수 있다. 삽입의 코돈 사용은 다양할 수 있다. 본 개시의 캡시드 단백질을 암호화하는 cap 유전자에 대한 대표적 뉴클레오티드 서열은 서열 51-72로서 제공된다. 일부 실시양태에서, 본 개시는 서열 51-72 중 하나와 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공한다. 적절한 뉴클레오티드 서열을 선택하고 본 개시의 임의의 캡시드 단백질을 암호화하기 위한 대체 뉴클레오티드 서열을 유도하는 것은 당업자의 기술 범위 내에 있다. 단백질 서열의 역 번역은 숙주 생물의 코돈 사용 표, 즉 인간에 대한 진핵 생물 코돈 사용을 사용하여 실행할 수 있다.
일부 실시양태에서, 본 개시는 서열번호 51{CR2 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 101, 또는 ARKVHIEVA(서열번호 101)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 52{CR5 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 102, 또는 ARKYQSDLA(서열번호 102)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 53{CR8 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 107, 또는 ARKHHGLEA(서열번호 107)에 대해 최대 1, 2, 3 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 54{CR17 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 103, 또는 APLTNTVKA(서열번호 103)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 55{CR18 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 104, 또는 ALKYHGPPA(서열번호 104)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 56{CR19 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 105, 또는 ARKYQGDMA(서열번호 105)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 57{CR20 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 106, 또는 ARKFHSTDA(서열번호 106)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 58{CR21 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 108, 또는 APGTNVTKA(서열번호 108)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 59{CR22 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 109, 또는 ARKMHMPDA(서열번호 109)에 대해 최대 1, 2, 3 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 60{CR23 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 110, 또는 APLKKIVQA(서열번호 110)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 61{CR24 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 111, 또는 APLGKKTSA(서열번호 111)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 62{CR25 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 112, 또는 APRGVKVTA(서열번호 112)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 63{CR26 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 113, 또는 APLAKSKSA(서열번호 113)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 64{CR27 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 114, 또는 APRTKGAVA(서열번호 114)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 65{CR28 폴리뉴클레오티드 서열}과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 115, 또는 APSGRKATA(서열번호 115)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 66과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 1과 관련하여 치환 K251R을 포함한다.
일부 실시양태에서, 본 개시는 서열번호 67과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 1과 관련하여 치환 S485A를 포함한다.
일부 실시양태에서, 본 개시는 서열번호 68과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 1과 관련하여 치환 S651A를 포함한다.
일부 실시양태에서, 본 개시는 서열번호 69와 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 1과 관련하여 치환 T578A를 포함한다.
일부 실시양태에서, 본 개시는 서열번호 70과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 1과 관련하여 치환 T582A를 포함한다.
일부 실시양태에서, 본 개시는 서열번호 71과 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 1과 관련하여 치환 Y709F를 포함한다.
일부 실시양태에서, 본 개시는 서열번호 72와 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드를 제공하고, 여기서 AAV5 캡시드 단백질은 서열번호 1과 관련하여 치환 Y693F를 포함한다.
일부 실시양태에서, 본 개시는 서열번호 9-34로부터 선택된 변형된 캡시드와 적어도 95%, 99%, 또는 100% 동일한 서열을 포함하는 AAV5 캡시드 단백질을 제공하고, 여기서 참조 캡시드 서열번호 1로부터의 변형된 캡시드에서 치환이 존재하고, 지정된 퍼센트 동일성 수준을 갖는 다른 치환, 임의로 보존적 치환이 허용된다.
일부 실시양태에서, 삽입 부위는 서열번호 1의 420 내지 460에 대응하는 모 서열의 위치에서 임의의 2개의, 임의로 인접한 아미노산 사이에 있다. 일부 실시양태에서, 삽입 부위는 서열번호 1의 444 및 445에 대응하는 모 서열 중의 인접한 아미노산 사이에 있다. 예시적 실시양태는 서열번호 31로서 개시된 AAV5 캡시드이다.
일부 실시양태에서, 본원에 개시된 재조합 아데노-연관 바이러스(rAAV) 비리온은 AAV5 캡시드 단백질을 포함하고, 여기서 캡시드 단백질은, 모 AAV5 캡시드와 비교하여, S651G, S651V, S651L, S651I, T578A, T578G, T578V, T578L, T578, T582A, T582G, T582V, T582L, 또는 T582I로부터 선택된 하나 이상의 치환; 및 유전자 산물을 암호화하는 뉴클레오티드 서열을 포함하는 이종 핵산을 포함한다.
일부 실시양태에서, 본원에 개시된 재조합 아데노-연관 바이러스(rAAV) 비리온은 AAV5 캡시드 단백질을 포함하고, 여기서 캡시드 단백질은, 모 AAV5 캡시드와 비교하여, S651A, T578A 또는 T582A로부터 선택되는 하나 이상의 치환; 및 유전자 산물을 암호화하는 뉴클레오티드 서열을 포함하는 이종 핵산을 포함한다.
AAV5 캡시드 단백질은 S651A 또는 S651V; T578A 또는 T578V; 또는 T582A 또는 T582V로부터 선택된 임의의 2개 치환 - 또는 S651A 또는 S651V; T578A 또는 T578V; 또는 T582A 또는 T582V의 3개 모두를 포함할 수 있다. 하기 돌연변이 조합은 본 개시에 의해 명시적으로 고려된다:
a) T578G + S651G;
b) T578V + S651V;
c) T578L + S651L;
d) T578I + S651I;
e) T582A + S651A;
f) T582G + S651G;
g) T582V + S651V;
h) T582L + S651L;
i) T582I + S651I;
j) T578A + T582A + S651A;
k) T578G + T582G + S651G;
l) T578V + T582V + S651V;
m) T578L + T582L + S651L; 및
n) T578I + T582I + S651I.
AAV5 캡시드 단백질은 S651A, T578A, 또는 T582A로부터 선택된 임의의 2개의 치환; 또는 S651A, T578A 또는 T582A의 3개 모두를 포함할 수 있다. 예를 들면, AAV5 캡시드 단백질은 서열번호 74-80 중 어느 하나, 또는 이에 대해 적어도 90%, 92%, 95%, 96%, 97%, 98%, 99% 또는 100% 동일한 서열일 수 있다.
T578A, T582A, 및/또는 S651A
MSFVDHPPDWLEEVGEGLREFLGLEAGPPKPKPNQQHQDQARGLVLPGYNYLGPGNGLDRGEPVNRADEVAREHDISYNEQLEAGDNPYLKYNHADAEFQEKLADDTSFGGNLGKAVFQAKKRVLEPFGLVEEGAKTAPTGKRIDDHFPKRKKARTEEDSKPSTSSDAEAGPSGSQQLQIPAQPASSLGADTMSAGGGGPLGDNNQGADGVGNASGDWHCDSTWMGDRVVTKSTRTWVLPSYNNHQYREIKSGSVDGSNANAYFGYSTPWGYFDFNRFHSHWSPRDWQRLINNYWGFRPRSLRVKIFNIQVKEVTVQDSTTTIANNLTSTVQVFTDDDYQLPYVVGNGTEGCLPAFPPQVFTLPQYGYATLNRDNTENPTERSSFFCLEYFPSKMLRTGNNFEFTYNFEEVPFHSSFAPSQNLFKLANPLVDQYLYRFVSTNNTGGVQFNKNLAGRYANTYKNWFPGPMGRTQGWNLGSGVNRASVSAFATTNRMELEGASYQVPPQPNGMTNNLQGSNTYALENTMIFNSQPANPGTTATYLEGNMLITSESETQPVNRVAYNVGGQMATNNQSST X APA X GTYNLQEIVPGSVWMERDVYLQGPIWAKIPETGAHFHPSPAMGGFGLKHPPPMMLIKNTPVPGNITSF X DVPVSSFITQYSTGQVTVEMEWELKKENSKRWNPEIQYTNNYNDPQFVDFAPDSTGEYRTTRPIGTRYLTRPL, 여기서 X = A, G, V, S, 또는 T (서열번호 73)
T578A
MSFVDHPPDWLEEVGEGLREFLGLEAGPPKPKPNQQHQDQARGLVLPGYNYLGPGNGLDRGEPVNRADEVAREHDISYNEQLEAGDNPYLKYNHADAEFQEKLADDTSFGGNLGKAVFQAKKRVLEPFGLVEEGAKTAPTGKRIDDHFPKRKKARTEEDSKPSTSSDAEAGPSGSQQLQIPAQPASSLGADTMSAGGGGPLGDNNQGADGVGNASGDWHCDSTWMGDRVVTKSTRTWVLPSYNNHQYREIKSGSVDGSNANAYFGYSTPWGYFDFNRFHSHWSPRDWQRLINNYWGFRPRSLRVKIFNIQVKEVTVQDSTTTIANNLTSTVQVFTDDDYQLPYVVGNGTEGCLPAFPPQVFTLPQYGYATLNRDNTENPTERSSFFCLEYFPSKMLRTGNNFEFTYNFEEVPFHSSFAPSQNLFKLANPLVDQYLYRFVSTNNTGGVQFNKNLAGRYANTYKNWFPGPMGRTQGWNLGSGVNRASVSAFATTNRMELEGASYQVPPQPNGMTNNLQGSNTYALENTMIFNSQPANPGTTATYLEGNMLITSESETQPVNRVAYNVGGQMATNNQSST A APA T GTYNLQEIVPGSVWMERDVYLQGPIWAKIPETGAHFHPSPAMGGFGLKHPPPMMLIKNTPVPGNITSF S DVPVSSFITQYSTGQVTVEMEWELKKENSKRWNPEIQYTNNYNDPQFVDFAPDSTGEYRTTRPIGTRYLTRPL (서열번호 74)
T582A
MSFVDHPPDWLEEVGEGLREFLGLEAGPPKPKPNQQHQDQARGLVLPGYNYLGPGNGLDRGEPVNRADEVAREHDISYNEQLEAGDNPYLKYNHADAEFQEKLADDTSFGGNLGKAVFQAKKRVLEPFGLVEEGAKTAPTGKRIDDHFPKRKKARTEEDSKPSTSSDAEAGPSGSQQLQIPAQPASSLGADTMSAGGGGPLGDNNQGADGVGNASGDWHCDSTWMGDRVVTKSTRTWVLPSYNNHQYREIKSGSVDGSNANAYFGYSTPWGYFDFNRFHSHWSPRDWQRLINNYWGFRPRSLRVKIFNIQVKEVTVQDSTTTIANNLTSTVQVFTDDDYQLPYVVGNGTEGCLPAFPPQVFTLPQYGYATLNRDNTENPTERSSFFCLEYFPSKMLRTGNNFEFTYNFEEVPFHSSFAPSQNLFKLANPLVDQYLYRFVSTNNTGGVQFNKNLAGRYANTYKNWFPGPMGRTQGWNLGSGVNRASVSAFATTNRMELEGASYQVPPQPNGMTNNLQGSNTYALENTMIFNSQPANPGTTATYLEGNMLITSESETQPVNRVAYNVGGQMATNNQSST T APA A GTYNLQEIVPGSVWMERDVYLQGPIWAKIPETGAHFHPSPAMGGFGLKHPPPMMLIKNTPVPGNITSF S DVPVSSFITQYSTGQVTVEMEWELKKENSKRWNPEIQYTNNYNDPQFVDFAPDSTGEYRTTRPIGTRYLTRPL (서열번호 75)
S651A
MSFVDHPPDWLEEVGEGLREFLGLEAGPPKPKPNQQHQDQARGLVLPGYNYLGPGNGLDRGEPVNRADEVAREHDISYNEQLEAGDNPYLKYNHADAEFQEKLADDTSFGGNLGKAVFQAKKRVLEPFGLVEEGAKTAPTGKRIDDHFPKRKKARTEEDSKPSTSSDAEAGPSGSQQLQIPAQPASSLGADTMSAGGGGPLGDNNQGADGVGNASGDWHCDSTWMGDRVVTKSTRTWVLPSYNNHQYREIKSGSVDGSNANAYFGYSTPWGYFDFNRFHSHWSPRDWQRLINNYWGFRPRSLRVKIFNIQVKEVTVQDSTTTIANNLTSTVQVFTDDDYQLPYVVGNGTEGCLPAFPPQVFTLPQYGYATLNRDNTENPTERSSFFCLEYFPSKMLRTGNNFEFTYNFEEVPFHSSFAPSQNLFKLANPLVDQYLYRFVSTNNTGGVQFNKNLAGRYANTYKNWFPGPMGRTQGWNLGSGVNRASVSAFATTNRMELEGASYQVPPQPNGMTNNLQGSNTYALENTMIFNSQPANPGTTATYLEGNMLITSESETQPVNRVAYNVGGQMATNNQSST T APA T GTYNLQEIVPGSVWMERDVYLQGPIWAKIPETGAHFHPSPAMGGFGLKHPPPMMLIKNTPVPGNITSF A DVPVSSFITQYSTGQVTVEMEWELKKENSKRWNPEIQYTNNYNDPQFVDFAPDSTGEYRTTRPIGTRYLTRPL (서열번호 76)
T578A 및 T582A
MSFVDHPPDWLEEVGEGLREFLGLEAGPPKPKPNQQHQDQARGLVLPGYNYLGPGNGLDRGEPVNRADEVAREHDISYNEQLEAGDNPYLKYNHADAEFQEKLADDTSFGGNLGKAVFQAKKRVLEPFGLVEEGAKTAPTGKRIDDHFPKRKKARTEEDSKPSTSSDAEAGPSGSQQLQIPAQPASSLGADTMSAGGGGPLGDNNQGADGVGNASGDWHCDSTWMGDRVVTKSTRTWVLPSYNNHQYREIKSGSVDGSNANAYFGYSTPWGYFDFNRFHSHWSPRDWQRLINNYWGFRPRSLRVKIFNIQVKEVTVQDSTTTIANNLTSTVQVFTDDDYQLPYVVGNGTEGCLPAFPPQVFTLPQYGYATLNRDNTENPTERSSFFCLEYFPSKMLRTGNNFEFTYNFEEVPFHSSFAPSQNLFKLANPLVDQYLYRFVSTNNTGGVQFNKNLAGRYANTYKNWFPGPMGRTQGWNLGSGVNRASVSAFATTNRMELEGASYQVPPQPNGMTNNLQGSNTYALENTMIFNSQPANPGTTATYLEGNMLITSESETQPVNRVAYNVGGQMATNNQSST A APA A GTYNLQEIVPGSVWMERDVYLQGPIWAKIPETGAHFHPSPAMGGFGLKHPPPMMLIKNTPVPGNITSF S DVPVSSFITQYSTGQVTVEMEWELKKENSKRWNPEIQYTNNYNDPQFVDFAPDSTGEYRTTRPIGTRYLTRPL (서열번호 77)
T578A 및 S651A
MSFVDHPPDWLEEVGEGLREFLGLEAGPPKPKPNQQHQDQARGLVLPGYNYLGPGNGLDRGEPVNRADEVAREHDISYNEQLEAGDNPYLKYNHADAEFQEKLADDTSFGGNLGKAVFQAKKRVLEPFGLVEEGAKTAPTGKRIDDHFPKRKKARTEEDSKPSTSSDAEAGPSGSQQLQIPAQPASSLGADTMSAGGGGPLGDNNQGADGVGNASGDWHCDSTWMGDRVVTKSTRTWVLPSYNNHQYREIKSGSVDGSNANAYFGYSTPWGYFDFNRFHSHWSPRDWQRLINNYWGFRPRSLRVKIFNIQVKEVTVQDSTTTIANNLTSTVQVFTDDDYQLPYVVGNGTEGCLPAFPPQVFTLPQYGYATLNRDNTENPTERSSFFCLEYFPSKMLRTGNNFEFTYNFEEVPFHSSFAPSQNLFKLANPLVDQYLYRFVSTNNTGGVQFNKNLAGRYANTYKNWFPGPMGRTQGWNLGSGVNRASVSAFATTNRMELEGASYQVPPQPNGMTNNLQGSNTYALENTMIFNSQPANPGTTATYLEGNMLITSESETQPVNRVAYNVGGQMATNNQSST A APA T GTYNLQEIVPGSVWMERDVYLQGPIWAKIPETGAHFHPSPAMGGFGLKHPPPMMLIKNTPVPGNITSF A DVPVSSFITQYSTGQVTVEMEWELKKENSKRWNPEIQYTNNYNDPQFVDFAPDSTGEYRTTRPIGTRYLTRPL (서열번호 78)
T582A 및 S651A
MSFVDHPPDWLEEVGEGLREFLGLEAGPPKPKPNQQHQDQARGLVLPGYNYLGPGNGLDRGEPVNRADEVAREHDISYNEQLEAGDNPYLKYNHADAEFQEKLADDTSFGGNLGKAVFQAKKRVLEPFGLVEEGAKTAPTGKRIDDHFPKRKKARTEEDSKPSTSSDAEAGPSGSQQLQIPAQPASSLGADTMSAGGGGPLGDNNQGADGVGNASGDWHCDSTWMGDRVVTKSTRTWVLPSYNNHQYREIKSGSVDGSNANAYFGYSTPWGYFDFNRFHSHWSPRDWQRLINNYWGFRPRSLRVKIFNIQVKEVTVQDSTTTIANNLTSTVQVFTDDDYQLPYVVGNGTEGCLPAFPPQVFTLPQYGYATLNRDNTENPTERSSFFCLEYFPSKMLRTGNNFEFTYNFEEVPFHSSFAPSQNLFKLANPLVDQYLYRFVSTNNTGGVQFNKNLAGRYANTYKNWFPGPMGRTQGWNLGSGVNRASVSAFATTNRMELEGASYQVPPQPNGMTNNLQGSNTYALENTMIFNSQPANPGTTATYLEGNMLITSESETQPVNRVAYNVGGQMATNNQSST T APA A GTYNLQEIVPGSVWMERDVYLQGPIWAKIPETGAHFHPSPAMGGFGLKHPPPMMLIKNTPVPGNITSF A DVPVSSFITQYSTGQVTVEMEWELKKENSKRWNPEIQYTNNYNDPQFVDFAPDSTGEYRTTRPIGTRYLTRPL (서열번호 79)
T578A, T582A, 및 S651A
MSFVDHPPDWLEEVGEGLREFLGLEAGPPKPKPNQQHQDQARGLVLPGYNYLGPGNGLDRGEPVNRADEVAREHDISYNEQLEAGDNPYLKYNHADAEFQEKLADDTSFGGNLGKAVFQAKKRVLEPFGLVEEGAKTAPTGKRIDDHFPKRKKARTEEDSKPSTSSDAEAGPSGSQQLQIPAQPASSLGADTMSAGGGGPLGDNNQGADGVGNASGDWHCDSTWMGDRVVTKSTRTWVLPSYNNHQYREIKSGSVDGSNANAYFGYSTPWGYFDFNRFHSHWSPRDWQRLINNYWGFRPRSLRVKIFNIQVKEVTVQDSTTTIANNLTSTVQVFTDDDYQLPYVVGNGTEGCLPAFPPQVFTLPQYGYATLNRDNTENPTERSSFFCLEYFPSKMLRTGNNFEFTYNFEEVPFHSSFAPSQNLFKLANPLVDQYLYRFVSTNNTGGVQFNKNLAGRYANTYKNWFPGPMGRTQGWNLGSGVNRASVSAFATTNRMELEGASYQVPPQPNGMTNNLQGSNTYALENTMIFNSQPANPGTTATYLEGNMLITSESETQPVNRVAYNVGGQMATNNQSST A APA A GTYNLQEIVPGSVWMERDVYLQGPIWAKIPETGAHFHPSPAMGGFGLKHPPPMMLIKNTPVPGNITSF A DVPVSSFITQYSTGQVTVEMEWELKKENSKRWNPEIQYTNNYNDPQFVDFAPDSTGEYRTTRPIGTRYLTRPL (서열번호 80)
임의의 상기 서열에서, 알라닌 치환은, 대신에, 발린(V), 글리신(G), 류신(L) 또는 이소류신(I)에 대한 치환일 수 있다.
일부 실시양태에서, 하나 이상의 아미노산 잔기는 야생형 AAV5 캡시드에 존재하는 잔기에 대해 보존된다. 예를 들면, 일부 실시양태에서, T581은 티로신(T)으로서 보존되거나, 또는 세린(S)으로서 반보존된다. 대조적으로, 미국 특허 제10,046,016호는, 폐 상피 세포의 감염성이 T581A 돌연변이에 의한 돌연변이에 의해 증가하는 것을 교시하고 있다.
정의
문맥상 달리 나타내지 않는 한, 본 발명의 특징은 임의의 조합으로 사용될 수 있다. 기재된 기능 또는 기능의 조합은 제외되거나 생략될 수 있다. 개별 실시양태에서 설명된 본 발명의 특정 특징은 또한 단일 실시양태에서 조합되어 제공될 수 있다. 단일 실시양태에서 설명된 본 발명의 특징은 개별적으로 또는 임의의 적절한 하위 조합으로 제공될 수도 있다. 실시양태의 모든 조합은, 각각의 모든 조합이 개별적으로 개시된 바와 같이, 본원에서 개시된다. 실시양태 및 요소의 모든 하위 조합은 이러한 모든 하위 조합이 개별적으로 개시된 것과 같이 본원에서 개시된다.
달리 정의되지 않는 한, 본원에서 사용되는 모든 기술 및 과학 용어는 본 발명이 속하는 기술 분야에서 당업자에 의해 일반적으로 이해되는 것과 동일한 의미를 갖는다. 상세한 설명은 독자의 편의를 위해서만 섹션으로 분할되어 있고, 임의의 섹션에 있는 개시는 또 다른 섹션과 조합될 수 있다. 본원에 기재된 것과 유사하거나 등가인 임의의 방법 및 재료가 또한, 본 발명의 실시 또는 시험에 사용될 수 있지만, 예시적 방법 및 재료가 이제 설명된다. 본원에 언급된 모든 간행물은 간행물이 인용되는 것과 관련된 방법 및/또는 재료를 개시 및 설명하기 위해 참조에 의해 도입된다. 출판물에 대한 언급은 그 출판물이 선행 기술임을 인정하는 것이 아니다.
단수 형태 "a", "an" 및 "the"는, 문맥에서 명시하지 않는 한, 복수 지시대상을 포함한다. 예를 들면, "재조합 AAV 비리온"에 대한 언급은 복수의 이러한 비리온을 포함하고, "심장 세포"에 대한 언급은 하나 이상의 심장 세포를 포함한다.
접속사 "및/또는"은 "및" 및 "또는"을 모두 의미하고, "및/또는"으로 연결된 목록은 나열된 항목 중 하나 이상의 가능한 모든 조합을 포함한다.
용어 "벡터"는, 세포에 전달될 폴리뉴클레오티드 또는 단백질을 포함하는 거대분자 또는 분자의 복합체를 지칭한다.
"AAV"는 아데노-연관 바이러스의 약자이다. 이 용어는, 서브타입이 표시된 경우를 제외하고, AAV의 모든 서브타입과 자연 발생 및 재조합 형태를 모두 포함한다. 약어 "rAAV"는 재조합 아데노-연관 바이러스를 지칭한다. "AAV"에는 AAV 또는 모든 서브타입이 포함된다. "AAV5"는 AAV 서브타입 5를 나타낸다. AAV의 다양한 혈청형의 게놈 서열, 뿐만 아니라 천연 역방향 말단 반복서열(ITR), Rep 단백질 및 캡시드 서브유닛의 서열은 문헌 또는 GenBank 등의 공개 데이터베이스에서 발견할 수 있다[참조: 예를 들면, GenBank 수탁 번호 NC_002077 (AAV1), AF063497 (AAV1), NC_001401 (AAV2), AF043303 (AAV2), NC_001729 (AAV3), NC_001829 (AAV4), U89790 (AAV4), NC_006152 (AAV5), AF513851 (AAV7), AF513852 (AAV8), and NC_006261 (AAV8)]. AAV를 기재하는 출판물에는 이하가 포함된다[참조: Srivistava et al. (1983) J. Virol. 45:555; Chiorini et al. (1998) J. Virol. 71:6823; Chiorini et al. (1999) J. Virol. 73:1309; Bantel-Schaal et al. (1999) J. Virol. 73:939; Xiao et al. (1999) J. Virol. 73:3994; Muramatsu et al. (1996) Virol. 221:208; Shade et al. (1986) J. Virol. 58:921; Gao et al. (2002) Proc. Nat. Acad. Sci. USA 99: 11854; Moris et al. (2004) Virology 33:375-383; Int’l Pat. Publ Nos. WO2018/222503A1, WO2012/145601A2, WO2000/028061A2, WO1999/61601A2, and WO1998/11244A2; U.S. Pat. Appl. Nos. 15/782,980 and 15/433,322; and U.S. Pat. Nos. 10,036,016, 9,790,472, 9,737,618, 9,434,928, 9,233,131, 8,906,675, 7,790,449, 7,906,111, 7,718,424, 7,259,151, 7,198,951, 7,105,345, 6,962,815, 6,984,517, and 6,156,303].
문맥에 따라, 당해 기술분야에서 사용되는 "AAV 벡터" 또는 "rAAV 벡터"는 rAAV 비리온에 패키징된 DNA 또는 rAAV 비리온 자체를 지칭한다. 본원에 사용된 바와 같이, 문맥상 달리 명백하지 않는 한, rAAV 벡터는 rAAV 비리온 내로 패키징될 수 있지만, 캡시드 또는 rAAV 비리온의 다른 단백질을 갖는 폴리뉴클레오티드 서열을 포함하는 핵산(전형적으로 플라스미드)을 지칭한다. 일반적으로, rAAV 벡터는, 이종 폴리뉴클레오티드 서열(즉, AAV 기원이 아닌 폴리뉴클레오티드) 및 이종 폴리뉴클레오티드 서열에 인접하는 1개 또는 2개의 AAV 역방향 말단 반복서열(ITR)을 포함한다. 2개의 ITR 중 1개만을 rAAV에 패키징할 수 있지만, 수득된 rAAV 비리온의 감염성은 유지될 수 있다[참조: Wu et al. (2010) Mol Ther. 18:80]. rAAV 벡터는 일본쇄(ssAAV) 또는 자가 상보성(scAAV) 중 어느 하나를 생성하도록 설계될 수 있다[참조: McCarty D. (2008) Mo. Ther. 16:1648-1656; WO2001/11034; WO2001/92551; WO2010/129021].
"rAAV 비리온"은, 적어도 하나의 바이러스 캡시드 단백질(예: VP1) 및 캡시드 단백질을 포함하는 캡시드화된 rAAV 벡터(또는 이의 단편)를 포함하는 세포외 바이러스 입자를 지칭한다.
간결함 및 명확성을 위해, 본 개시는 "캡시드 단백질" 또는 "캡시드 단백질들"을 지칭한다. 당업자는 이러한 참조가 VP1, VP2 또는 VP3, 또는 VP1, VP2 및 VP3의 조합을 지칭한다는 것을 이해한다. 야생형 AAV 및 대부분의 재조합 발현 시스템과 동일하게, VP1, VP2 및 VP3은 동일한 개방 판독 프레임에서 발현되고, VP3을 암호화하는 서열의 조작은 필연적으로 VP1 및 VP2의 C-말단 도메인의 서열을 변경한다. 상이한 개방 판독 프레임으로부터 캡시드 단백질을 발현시킬 수도 있고, 이 경우, 수득된 rAAV 비리온의 캡시드는 야생형 및 조작된 캡시드 단백질의 혼합물, 및 상이한 조작된 캡시드 단백질의 혼합물을 함유할 수 있다.
본원에 사용된 용어 "역방향 말단 반복서열" 또는 "ITR"은, 이들의 대칭성 때문에 그렇게 명명된 AAV 바이러스 시스-요소를 지칭한다. 이러한 요소는 AAV 게놈의 효율적 증식에 필수적이다. 이론에 얽매이지 않고, ITR 기능에 필수적인 최소 요소는 Rep-결합 부위 및 말단 분해 부위에 추가하여, 헤어핀 형성을 가능하게 하는 가변 회문 서열인 것으로 여겨진다. 본 개시는 AAV 게놈을 생성하는 대체 수단이 존재할 수 있거나, 본 개시의 캡시드 단백질과 양립 가능하도록 전향적으로 개발될 수 있음을 고려한다.
"헬퍼 바이러스 기능"은 AAV 복제 및 패키징을 가능하게 하는 헬퍼 바이러스 게놈에 암호화된 기능을 지칭한다.
"패키징"은 rAAV 벡터의 캡슐화를 포함하는 rAAV 비리온의 조립을 초래하는 일련의 세포내 이벤트를 지칭한다. AAV "rep" 및 "cap" 유전자는 아데노-연관 바이러스의 복제 및 캡슐화 단백질을 암호화하는 폴리뉴클레오티드 서열을 지칭한다. AAV rep 및 cap은 본원에서 AAV "패키징 유전자"로 지칭된다. 패키징에는 헬퍼 바이러스 자체, 또는 보다 일반적으로 재조합 시스템에서 헬퍼 프리 시스템(즉, 하나 이상의 헬퍼 플라스미드)에 의해 제공하는 헬퍼 바이러스 기능 중 어느 하나가 필요하다.
AAV에 대한 "헬퍼 바이러스"는 AAV(예: 야생형 AAV)가 포유동물 세포에 의해 복제 및 패키징되는 것을 가능하게 하는 바이러스를 지칭한다. 헬퍼 바이러스는 아데노바이러스, 헤르페스바이러스 또는 백시니아 등의 폭스바이러스일 수 있다.
"감염성" 비리온 또는 바이러스 입자는, 유능하게 조립된 바이러스 캡시드를 포함하고, 비리온이 향성인 세포 내로 폴리뉴클레오티드 성분을 전달할 수 있는 것이다. 이 용어는 반드시 바이러스의 복제 능력을 의미하는 것은 아니다.
"감염성"은 세포를 굴절시키는 비리온의 능력의 측정치를 의미한다. 감염성은 전체 바이러스 입자에 대한 감염성 바이러스 입자의 비율로서 표현될 수 있다. 감염성은 일반적으로 특정 세포 유형과 관련하여 결정된다. 생체내 또는 시험관 내에서 모두 측정할 수 있다. 전체 바이러스 입자에 대한 감염성 바이러스 입자의 비율을 결정하는 방법은 당해 기술분야에 공지되어 있다[참조: 예를 들면, Grainger et al. (2005) Mol. Ther. 11:S337 (TCID50 감염성 역가 검정을 기재); and Zolotukhin et al. (1999) Gene Ther. 6:973]
용어 "모 캡시드" 또는 "모 서열"은 입자 캡시드 또는 서열이 유래하는 참조 서열을 지칭한다. 달리 명시되지 않는 한, 모 서열은 조작된 캡시드 단백질과 동일한 혈청형의 야생형 캡시드 단백질의 서열을 지칭한다.
"복제능력이 있는" 바이러스(예: 복제능력이 있는 AAV)는 감염성이고 감염된 세포에서도 복제될 수 있는 바이러스를 지칭한다(즉, 헬퍼 바이러스 또는 헬퍼 바이러스 기능의 존재하에서). 일부 실시양태에서, 본 개시의 rAAV 비리온은 rep 유전자, 또는 rep 및 cap 유전자 둘 모두를 결여하는, 따라서 복제능력이 없는 게놈을 포함한다.
본 개시내용의 실시는, 달리 지시되지 않는 한, 당해 기술분야의 기술 내에 있는 조직 배양, 면역학, 분자 생물학, 세포 생물학 및 재조합 DNA의 종래의 기술을 사용한다[참조: 예를 들면, Sambrook and Russell eds. (2001) Molecular Cloning: A Laboratory Manual, 3rd edition; Ausubel et al. eds. (2007) Current Protocols in Molecular Biology; Methods in Enzymology (Academic Press, Inc., N.Y.); MacPherson et al. (1991) PCR 1: A Practical Approach (IRL Press at Oxford University Press); MacPherson et al. (1995) PCR 2: A Practical Approach; Harlow and Lane eds. (1999) Antibodies, A Laboratory Manual; Freshney (2005) Culture of Animal Cells: A Manual of Basic Technique, 5thedition; Gait ed. (1984) Oligonucleotide Synthesis; U.S. Pat. No. 4,683,195; Hames and Higgins eds. (1984) Nucleic Acid Hybridization; Anderson (1999) Nucleic Acid Hybridization; Hames and Higgins eds. (1984) Transcription and Translation; IRL Press (1986) Immobilized Cells and Enzymes; Perbal (1984) A Practical Guide to Molecular Cloning; Miller and Calos eds. (1987) Gene Transfer Vectors for Mammalian Cells (Cold Spring Harbor Laboratory); Makrides ed. (2003) Gene Transfer and Expression in Mammalian Cells; Mayer and Walker eds. (1987) Immunochemical Methods in Cell and Molecular Biology (Academic Press, London); Herzenberg et al. eds (1996) Weir’s Handbook of Experimental Immunology; Manipulating the Mouse Embryo: A Laboratory Manual, 3rd edition (2002) Cold Spring Harbor Laboratory Press; Sohail (2004) Gene Silencing by RNA Interference: Technology and Application (CRC Press); and Sell (2013) Stem Cells Handbook].
용어 "핵산" 및 "폴리뉴클레오티드"는 교환가능하게 사용되고, 데옥시리보뉴클레오티드 또는 리보뉴클레오티드 또는 이들의 유사체 중 어느 하나의 임의 길이의 뉴클레오티드의 폴리머 형태를 지칭한다. 폴리뉴클레오티드의 비제한적 예는 선형 및 원형 핵산, 메신저 RNA(mRNA), cDNA, 재조합 폴리뉴클레오티드, 벡터, 프로브 및 프라이머를 포함한다. 달리 명시되거나 요구되지 않는 한, 폴리뉴클레오티드인 본원에 기재된 본 발명의 임의의 실시양태는 이본쇄 형태 및 이본쇄 형태를 구성하는 것으로 공지되거나 예측되는 2개의 상보적 일본쇄 형태 각각을 모두 포함한다.
용어 "폴리펩티드" 및 "단백질"은 본원에서 교환가능하게 사용되고, 임의 길이의 아미노산의 폴리머 형태를 지칭하고, 이는 유전적으로 암호화된 아미노산 및 비유전적으로 암호화된 아미노산, 화학적으로 또는 생화학적으로 변형되거나 유도체화된 아미노산, 및 변형된 펩티드 골격을 갖는 폴리펩티드를 포함할 수 있다. 이 용어는 또한 변형된 아미노산 폴리머를 포함한다; 예를 들면, 디설파이드 결합 형성, 글리코실화, 지질화, 인산화 또는 표지 성분과의 접합.
용어 "펩티드"는 짧은 폴리펩티드, 예를 들면, 약 4 내지 30개의 아미노산 잔기를 갖는 펩티드를 지칭한다.
용어 "단리된"은 비리온, 세포, 조직, 폴리뉴클레오티드, 펩티드, 폴리펩티드 또는 단백질이 통상 자연에서 정상적으로 결합되어 있는 세포 및 기타 구성요소로부터 분리된 것을 의미한다. 예를 들면, 단리된 세포는 상이한 표현형 또는 유전자형의 조직 또는 세포로부터 분리된 세포이다.
본원에 사용된 바와 같이, "서열 동일성" 또는 "동일성"은 목적 서열과 참조 서열 사이에 동일한 아미노산 수의 백분율을 지칭한다. 일반적으로, 동일성은 목적 서열을 참조 서열에 정렬하고, 정렬된 서열 사이에서 동일한 아미노산의 수를 결정하고, 그 수를 참조 서열의 총 아미노산 수로 나누고, 그 결과에 100을 곱하여 백분율을 산출함으로써 결정된다. 서열은 ncbi.nlm.nih.gov에서 입수가능한 BLAST 등의 다양한 컴퓨터 프로그램을 사용하여 정렬할 수 있다. 정렬을 위한 다른 기술은 문헌[참조: Methods in Enzymology, vol. 266: Computer Methods for Macromolecular Sequence Analysis (1996); and Meth. Mol. Biol. 70: 173-187 (1997); J. Mol. Biol. 48: 44]에 기재되어 있다. 숙련자는, 서열 길이, 분기, 참조 서열에 대한 삽입 또는 결실의 존재 또는 부재를 포함하는 다양한 요인에 따라 적절한 정렬 방법을 선택할 수 있다.
폴리뉴클레오티드에 적용되는 "재조합"은, 폴리뉴클레오티드가 클로닝, 제한 또는 결찰 단계 및 자연에서 발견되는 폴리뉴클레오티드와 구별되는 작제물을 생성하는 기타 절차의 다양한 조합의 산물이거나, 폴리뉴클레오티드가 합성 올리고뉴클레오티드로부터 조립되는 것을 의미한다. "재조합" 단백질은 재조합 폴리펩티드로부터 생성된 단백질이다. 재조합 비리온은 재조합 폴리뉴클레오티드 및/또는 재조합 단백질, 예를 들면, 재조합 캡시드 단백질을 포함하는 비리온이다.
"유전자"는, 전사 및 번역된 후에 특정 단백질을 암호화할 수 있는 적어도 하나의 개방 판독 프레임을 함유하는 폴리뉴클레오티드를 지칭한다. "유전자 산물"은 특정 유전자의 발현으로부터 발생하는 분자이다. 유전자 산물은 폴리펩티드, 단백질, 앱타머, 간섭 RNA 또는 mRNA를 포함할 수 있지만, 이들로 한정되지 않는다. 유전자 편집 시스템(예: CRISPR/Cas 시스템)은 하나의 유전자 산물로서, 또는 시스템을 작성하기 위해 필요한 몇몇 유전자 산물(예: Cas 단백질 및 가이드 RNA)로서 설명될 수 있다.
"짧은 헤어핀 RNA" 또는 shRNA는 siRNA를 발현시키기 위해 사용되는 폴리뉴클레오티드 작제물이다.
"조절 요소" 또는 "조절 서열"은, 폴리뉴클레오티드의 복제, 복사, 전사, 스플라이싱, 번역 또는 분해를 포함하는, 폴리뉴클레오티드의 기능적 조절에 기여하는 분자의 상호작용에 관여하는 뉴클레오티드 서열이다. 조절은 프로세스의 빈도, 속도 또는 특이성에 영향을 미칠 수 있고, 본질적으로 증강되거나 억제될 수 있다. 조절 요소에는 프로모터 및/또는 인핸서 등의 전사 조절 서열이 포함된다.
"프로모터"는, RNA 폴리머라제에 결합하고, 일반적으로 프로모터로부터 하류(3' 방향)에 위치하는 코딩(coding) 영역의 전사를 개시하는 특정 조건하에서 가능한 DNA 서열이다. 본원에서 사용되는 용어 "조직 특이적 프로모터"는 심장 조직 등의 특정 기관 또는 조직의 세포에서 작동가능한 프로모터를 지칭한다.
"작동가능하게 연결된" 또는 "작동적으로 연결된"은 유전 요소의 병치를 지칭하고, 여기서 요소는 각각이 예상된 방식으로 작동하는 것을 가능하게 하는 관계에 있다. 예를 들면, 프로모터가 코딩 서열의 전사 개시를 돕는 경우, 프로모터는 코딩 영역에 작동가능하게 연결된다. 이 기능적 관계가 유지되는 한, 프로모터와 코딩 영역 사이에 잔기가 개재할 수 있다.
"발현 벡터"는, 표적 세포에서 유전자 산물의 발현에 영향을 미치기 위해 사용되는 목적 유전자 산물을 암호화하는 코딩 서열을 포함하는 벡터이다. 발현 벡터는, 유전자 산물의 발현을 촉진하기 위해 코딩 서열에 작동가능하게 연결된 조절 요소를 포함한다.
용어 "발현 카세트"는, 표적 세포에서 유전자 산물의 발현에 영향을 미치기 위해 사용되는 목적 유전자 산물을 암호화하는 코딩 서열을 포함하는 이종 폴리뉴클레오티드를 지칭한다. 달리 명시되지 않는 한, AAV 벡터의 발현 카세트는 ITR 사이(및 포함하지 않음)의 폴리뉴클레오티드를 포함한다.
본원에 사용된 용어 "유전자 전달" 또는 "유전자 도입"은 외래 핵산 서열, 예를 들면, DNA를 숙주 세포 내로 확실하게 삽입하기 위한 방법 또는 시스템을 지칭한다. 이러한 방법은 도입되지 않은 전달된 DNA의 일시적 발현, 염색체외 복제 및 전달된 레플리콘(예: 에피솜)의 발현, 또는 전달된 유전 물질의 숙주 세포의 게놈 DNA로의 통합을 초래할 수 있다.
"이종"은, 그것이 비교되는 나머지 실체와는 유전자형이 상이한 실체에서 유래된 것을 의미한다. 예를 들면, 유전 공학 기술에 의해 상이한 종에서 유래된 플라스미드 또는 벡터에 도입된 폴리뉴클레오티드는 이종 폴리뉴클레오티드이다. 본래의 코딩 서열로부터 제거되고 그것이 자연적으로 연결되어 있는 것이 발견되지 않은 코딩 서열에 작동가능하게 연결된 프로모터는 이종 프로모터이다. 따라서, 예를 들면, 이종 핵산을 포함하는 rAAV는 자연 발생 AAV에 정상적으로 포함되지 않는 핵산을 포함하는 rAAV이다.
용어 "유전적 변경" 및 "유전적 변형"(및 이의 문법적 변이체)은 본원에서 교환가능하게 사용되고, 유사분열 또는 감수분열 이외의 방법으로 유전 요소(예: 폴리뉴클레오티드)가 세포 내로 도입되는 프로세스를 지칭한다. 요소는 세포에 대해 이종일 수도 있고, 세포에 이미 존재하는 요소의 추가 카피 또는 개선된 버전일 수도 있다. 유전적 변경은, 예를 들면, 전기천공, 인산칼슘 침전, 또는 폴리뉴클레오티드-리포솜 복합체와의 접촉 등의 당해 기술분야에 공지된 임의의 프로세스를 통해 재조합 플라스미드 또는 다른 폴리뉴클레오티드로 세포를 형질감염시킴으로써 수행될 수 있다. 유전적 변경은 또한, 예를 들면, 형질도입 또는 벡터에 의한 감염에 의해 영향을 받을 수 있다.
폴리뉴클레오티드 서열이 시험관내에서 세포의 장기 배양 동안 그 기능을 실행하기 위해 이용가능한 경우, 세포는 폴리뉴클레오티드 서열로 "안정적으로" 변경, 형질도입, 유전적으로 변형 또는 형질전환되었다고 한다. 일반적으로, 이러한 세포는, 변경된 세포의 자손에게도 유전될 수 있는 유전적 변경이 도입된다는 점에서, "유전적으로" 변경된다(유전적으로 변형).
본원에 사용된 용어 "형질감염"은 세포에 의한 외인성 핵산 분자의 흡수를 지칭한다. 외인성 핵산이 세포막의 내부에 도입되었을 때, 세포는 "형질감염"되었다. 다수의 형질감염 기술이 일반적으로 당해 기술분야에 공지되어 있다[참조: 예를 들면, Graham et al. (1973) Virology, 52:456, Sambrook et al. (1989) Molecular Cloning, a laboratory manual, Cold Spring Harbor Laboratories, New York, Davis et al. (1986) Basic Methods in Molecular Biology, Elsevier, and Chu et al. (1981) Gene 13:197]. 이러한 기술을 사용하여 하나 이상의 외인성 핵산 분자를 적합한 숙주 세포에 도입할 수 있다.
본원에 사용된 용어 "형질도입"은, 야생형 비리온에 의한 "감염"과 대조적으로, 재조합 비리온에 의한 외인성 핵산의 세포 내로의 전달을 지칭한다. 재조합 비리온과 관련하여 감염이 사용되는 경우, "형질도입" 및 "감염성"이라는 용어는 동의어이고, 따라서 "감염성" 및 "형질도입 효율"은 동등하고, 유사한 방법을 사용하여 결정할 수 있다.
달리 명시되지 않는 한, 모든 의료 용어는, 예를 들면, 문헌[참조: Harrison’s Principles of Internal Medicine, 15ed.] 등과 같이 의약 전문가에 의해 사용되는 용어의 일반적 의미를 제공하고, 이는 모든 목적, 특히 심장 또는 심혈관 질환, 장애, 상태 및 기능장애에 대한 챕터에서 참조에 의해 그 전체가 도입된다.
"치료", "치료하는" 및 "치료하다"는 질환, 장애 또는 상태 및/또는 그 증상의 유해하거나 기타 바람직하지 않은 영향을 감소 또는 개선하기 위해, 약제를 사용하여 질환, 장애 또는 상태에 작용하는 것으로 정의된다.
"투여", "투여하는" 등은, 본 발명의 조성물과 관련하여 사용되는 경우, 직접 투여(의료 전문가에 의한 대상체에 대한 투여 또는 대상체에 의한 자가 투여) 및/또는 간접 투여(환자에게 조성물을 처방)를 모두 의미한다. 전형적으로, 유효량이 투여되며, 이 양은 당업자에 의해 결정될 수 있다. 임의의 투여 방법이 사용될 수 있다. 대상체에 대한 투여는, 예를 들면, 정맥내, 동맥내, 근육내, 혈관내 또는 심근내 전달에 의해 달성될 수 있다.
본원에 사용된 바와 같이, 조성물의 양과 관련하여 용어 "유효량" 등은 원하는 생리학적 결과(예를 들면, 세포의 재프로그래밍 또는 질환의 치료)를 유도하기에 충분한 양을 지칭한다. 유효량은 하나 이상의 투여, 적용 또는 투여량으로 투여될 수 있다. 이러한 전달은 개별 투여 단위가 사용되는 기간, 조성물의 생체이용능, 투여 경로 등을 포함하는 다수의 변수에 따라 달라진다. 그러나, 임의의 특정 대상체에 대한 조성물(예: rAAV 비리온)의 특정 양은 사용된 특정 약제의 활성, 대상의 연령, 체중, 일반적 건강, 성별 및 식이, 투여 시간, 배설 속도, 조성물의 조합, 치료되는 특정 질환의 중증도 및 투여 형태를 포함하는 다양한 요인에 의존하는 것으로 이해된다.
용어 "개체", "대상체" 및 "환자"는 본원에서 교환가능하게 사용되고, 인간 및 비인간 영장류(예: 유인원); 포유동물 스포츠 동물(예: 말); 포유동물 농장 동물(예: 양, 염소 등); 포유동물 애완동물(예: 개, 고양이 등); 및 설치류(예: 마우스, 래트 등)를 포함하지만 이들로 한정되지 않는 포유동물을 지칭한다.
용어 "심장 병리" 또는 "심장 기능장애"는 동일한 의미로 사용되고, 심장의 펌프 기능 장애를 나타낸다. 여기에는, 예를 들면, 수축성 장애, 이완 능력 장애(때로는 이완기 기능장애라고도 함), 심장 판막의 비정상 또는 부적절한 기능, 심장 근육 질환(심근증이라고도 함), 협심증, 심근 허혈 및/또는 심근에 대한 불충분한 혈액 공급을 특징으로 하는 경색 등의 질환, 아밀로이드증 및 혈색소 침착증 등의 침윤성 질환, 전체적 또는 국소적 비대(일부 종류의 심근증 또는 전신성 고혈압증에서 발생할 수 있는 것 등), 심장 챔버 사이의 비정상적 소통을 포함한다.
본원에 사용된 바와 같이, 용어 "심근증(cardiomyopathy)"은 심근에 직접 영향을 미치는 임의의 질환 또는 기능장애를 지칭한다. 질환 또는 장애의 병인은, 예를 들면, 염증성, 대사성, 독성, 침윤성, 섬유형성성, 혈액학적, 유전적 또는 기원이 불명일 수 있다. 2개의 기본 형태가 인식되고 있다: (1) 원인 불명의 심근 질환으로 이루어진 원발성 유형; (2) 공지된 원인의 심근 질환으로 이루어지거나 다른 기관계가 관여하는 질환과 관련된 이차 유형. "특정 심근증"은 특정 전신 또는 심장 장애와 관련된 심장 질환을 지칭한다. 예로는 고혈압 및 대사성 심근증이 있다. 심근증에는 확장성 심근병증(DCM)이 포함되고, 이는 좌심실 및/또는 우심실 수축기 펌프 기능이 손상되어 진행성 심장 비대가 발생하는 장애이고; 비대성 심근증은 고혈압 또는 대동맥 협착증 등의 명백한 원인이 없는 좌심실 비대를 특징으로 하고; 구속성 심근증은 비정상적 확장기 기능 및 심실 충만을 방해하는 과도하게 단단한 심실 벽을 특징으로 한다. 심근증은 또한 좌심실 압밀화장애(left ventricular non-compaction), 부정맥성 우심실 심근증(arrhythmogenic right ventricular cardiomyopathy) 및 부정맥성 우심실 이형성증(arrhythmogenic right ventricular dysplasia)을 포함한다.
"심부전(heart failure)"은, 심장 기능의 이상이 대사 조직의 요건에 대응하는 속도로 혈액을 펌핑하는 것의 실패의 원인이고/이거나, 심장이 비정상적으로 상승된 이완기 용적으로부터만 그렇게 하는 것을 가능하게 하는 병적 상태를 지칭한다. 심부전에는 수축기 및 이완기 장애가 포함된다. 심부전 환자는, 심박출량이 낮은 환자(일반적으로 허혈성 심장 질환, 고혈압, 확장성 심근증 및/또는 판막 또는 심막 질환에 속발성)와 심박출량이 증가한 환자(일반적으로 갑상선 기능 항진증(hyperthyroidism), 빈혈(anemia), 임신(pregnancy), 동정맥 누공(arteriovenous fistulas), 각기병(beriberi) 및 파제트병(Paget's disease))로 분류된다. 심부전에는 구출률이 감소된 심부전(HFrEF)과 구출률이 유지된 심부전(HFpEF)이 포함된다.
문구 "약제학적으로 허용되는"은, 건전한 의학적 판단의 범위 내에서, 과다한 독성, 자극, 알레르기 반응 또는 기타 문제 또는 합병증 없이, 합리적 이익/위험 비율에 상응하게, 인간 및 동물의 조직과 접촉하여 사용하기에 적합한 화합물, 재료, 조성물 및/또는 투여 형태를 지칭하기 위해 본원에 사용된다.
본원에 사용된 용어 "정제된"은, 관련 없는 재료, 즉 재료가 수득되는 천연 재료를 포함하는 불순물의 존재를 감소 또는 제거하는 조건하에 단리된 재료를 지칭한다. 예를 들면, 정제된 rAAV 벡터 DNA는 바람직하게는 조직 배양 성분, 오염물 등을 포함하는 세포 또는 배양 성분을 실질적으로 포함하지 않는다.
손상된 심장 조직의 맥락(context)에서 본원에서 사용된 용어 "재생하다", "재생" 등은 이들의 통상의 의미로 제공되고, 예를 들면, 허혈, 경색, 재관류 또는 기타 질환에 기인하여 손상된 심장 또는 심장 조직에서 새로운 심장 조직을 성장 및/또는 발달시키는 프로세스를 또한 지칭하는 것이다. 일부 실시양태에서, 심장 조직 재생은 심근세포의 생성을 포함한다.
본원에 사용된 용어 "치료 유전자"는, 발현되면, 그것이 존재하는 세포 또는 조직, 또는 유전자가 발현되는 포유동물에 유익한 효과를 부여하는 유전자를 지칭한다. 유익한 효과의 예는 상태 또는 질환의 징후 또는 증상의 개선, 상태 또는 질환의 예방 또는 억제, 또는 원하는 특성의 부여를 포함한다. 치료 유전자에는 세포 또는 포유동물의 유전적 결함을 부분적으로 또는 전체적으로 교정하는 유전자가 포함된다.
본원에서 사용된 바와 같이, 용어 "기능성 심근세포"는 전기 신호를 송신 또는 수신할 수 있는 분화된 심근세포를 지칭한다. 일부 실시양태에서, 심근세포는, 그것이 활동 전위 및/또는 Ca2+ 과도현상 등의 전기생리학적 특성을 나타내는 경우, 기능성 심근세포라고 한다.
본원에 사용된 바와 같이, "분화된 비-심장 세포"는, 성체 생물의 모든 세포 유형으로 분화할 수 없고(즉, 만능 세포가 아님), 심장 계통 이외의 세포 계통(예를 들면, 신경 계통 또는 결합 조직 계통)의 것인 세포를 지칭한다. 분화된 세포는 다능성 세포, 올리고능성 세포, 단능성 세포, 전구 세포, 및 말단 분화된 세포를 포함하지만, 이들로 한정되지 않는다. 특정 실시양태에서, 보다 덜 강력한 세포는 보다 더 강력한 세포와 관련하여 "분화된" 것으로 간주된다.
"체세포"는, 생물의 바디를 형성하는 세포이다. 체세포에는 생체내의 장기, 피부, 혈액, 뼈 및 결합 조직을 구성하는 세포가 포함되지만, 생식 세포는 포함되지 않는다.
본원에 사용된 바와 같이, 용어 "전능성(totipotent)"은 생물의 모든 세포 계통을 형성하는 세포의 능력을 의미한다. 예를 들면, 포유류에서는 접합체와 최초 난할기의 할구만이 전능성이다.
본원에 사용된 바와 같이, 용어 "만능성(pluripotent)"은 신체 또는 체세포의 모든 계통을 형성하는 세포의 능력을 의미한다. 예를 들면, 배아 줄기 세포는 외배엽, 중배엽 및 내배엽의 3개 배엽의 각각으로부터 세포를 형성할 수 있는 만능 줄기 세포의 일종이다. 만능 세포는 나노그(Nanog) 및 Rex1 등의 마커의 발현에 의해 인식될 수 있다.
본원에 사용된 바와 같이, 용어 "다능성(multipotent)"은 성체 줄기 세포가 한 계통의 복수의 세포 유형을 형성하는 능력을 지칭한다. 예를 들면, 조혈 줄기 세포는 혈액 세포 계통의 모든 세포, 예를 들면, 림프구 및 골수 세포를 형성할 수 있다.
본원에 사용된 바와 같이, 용어 "올리고능성(oligopotent)"은, 성체 줄기 세포가 소수의 상이한 세포 유형만으로 분화하는 능력을 지칭한다. 예를 들면, 림프계 또는 골수계 줄기 세포는 각각 림프 또는 골수 계통 중 어느 하나의 세포를 형성할 수 있다.
본원에 사용된 바와 같이, 용어 "단능성(unipotent)"은 단일 세포 유형을 형성하는 세포의 능력을 의미한다. 예를 들면, 정자 줄기 세포는 정자 세포만을 형성할 수 있다.
본원에 사용된 바와 같이, 용어 "재프로그래밍" 또는 "분화전환"은, 세포를 다능성 줄기 세포의 특징을 나타내는 세포로 탈분화하는 중간 프로세스 없이, 상이한 유형의 세포(예: 섬유아세포)로부터 특정 계통의 세포(예: 심장 세포)를 생성하는 것을 지칭한다.
본원에 사용된 바와 같이, 용어 "심장 세포"는, 심장 수축 또는 혈액 공급 등의 심장 기능을 제공하거나, 심장 구조를 유지하는 역할을 하는, 심장에 존재하는 임의의 세포를 지칭한다. 본원에 사용된 심장 세포는 심장의 심외막, 심근 또는 심내막에 존재하는 세포를 포함한다. 심장 세포는 또한, 예를 들면, 심근 세포 또는 심근 세포, 게다가 관상 동맥 또는 정맥의 세포 등의 심장 혈관계의 세포를 포함한다. 심장 세포의 다른 비제한적 예는, 상피 세포, 내피 세포, 섬유아세포, 심장 줄기 세포 또는 전구 세포, 심장 전도 세포, 및 심장 근육, 혈관 및 심장 세포 지지 구조를 구성하는 심장 페이스메이킹 세포를 포함한다. 심장 세포는, 예를 들면, 배아 줄기 세포 또는 유도 만능 줄기 세포를 포함하는 줄기 세포로부터 유래될 수 있다.
본원에 사용된 용어 "심근세포" 또는 "심근세포들"은, 골격근 세포와 대조적으로, 포유동물 심장에서 자연적으로 발견되는 근절-함유 횡문근 세포를 지칭한다. 심근세포는 미오신 중쇄, 미오신 경쇄, 심장 α-액티닌 등의 단백질 등의 특수 분자의 발현을 특징으로 한다. 본원에 사용된 용어 "심근세포"는, 임의의 심근세포 아집단 또는 심근세포 서브타입, 예를 들면, 심방, 심실 및 페이스메이커 심근세포를 포함하는 포괄적 용어이다.
용어 "심근세포-유사 세포"는 심근세포와 특징을 공유하지만, 모든 특징을 공유하지 않을 수 있는 세포를 의미하기 위한 것이다. 예를 들면, 심근세포-유사 세포는 특정 심장 유전자의 발현에서 심근세포와는 상이할 수 있다.
용어 "배양" 또는 "세포 배양"는, 인공의 시험관내 환경에서 세포를 유지하는 것을 의미한다. "세포 배양 시스템"은 세포 집단이 단층 또는 현탁액 중에서 성장할 수 있는 배양 조건을 지칭하기 위해 본원에서 사용된다. "배양 배지"는, 세포의 배양, 성장 또는 증식을 위한 영양 용액을 지칭하기 위해 본원에서 사용된다. 배양 배지는, 세포를 특정 상태(예: 만능성 상태, 정지 상태 등)로 유지하는 능력, 세포를 성숙시키는 능력, 일부 경우에, 구체적으로는, 전구 세포의 특정 계통의 세포(예를 들면, 심근세포)로의 분화를 촉진시키는 능력 등의 기능적 특성을 특징으로 할 수 있지만, 이들로 한정되지 않는다.
본원에 사용된 바와 같이, 용어 "발현" 또는 "발현하다"는 폴리뉴클레오티드가 mRNA로 전사되는 프로세스 및/또는 전사된 mRNA가 후속적으로 펩티드, 폴리펩티드 또는 단백질로 번역되는 프로세스를 지칭한다. 폴리뉴클레오티드가 게놈 DNA로부터 유래하는 경우, 발현은 진핵 세포에서 mRNA의 스플라이싱을 포함할 수 있다. 유전자의 발현 수준은 세포 또는 조직 샘플 중의 mRNA 또는 단백질의 양을 측정함으로써 결정할 수 있다.
용어 "유도된 심근세포" 또는 약어 "iCM"은 심근세포(및/또는 심근세포-유사 세포)로 형질전환된 비-심근세포(및 이의 자손)를 지칭한다. 본 개시의 방법은, 예를 들면, 다른 기술을 증강시키기 위해, 유도 심근세포를 생성하기 위해 현재 공지되어 있거나, 이후에 발견되는 임의의 방법과 조합하여 사용될 수 있다.
본원에서 사용된 용어 "유도 만능 줄기세포-유래 심근세포"는 심근세포-유사 세포로 분화된 인간 유도 만능 줄기세포를 지칭한다. 제조된 iPS-CM 세포에 대한 예시적 방법은 문헌[참조: Karakikes et al. Circ Res. 2015 Jun 19; 117(1): 80-88]에 제공되어 있다.
본원에 사용된 용어 "인간 심장 섬유아세포" 및 "마우스 심장 섬유아세포"는 각각 인간 또는 마우스의 성체 심장의 심실에서 단리되고 생체외 배양에서 유지되는 1차 세포를 지칭한다.
본원에 사용된 용어 "비-심근세포"는 본원에서 정의되고 사용되는 "심근세포"의 기준을 충족하지 않는 세포 조제물 중의 임의의 세포 또는 세포 집단을 지칭한다. 비-심근세포의 비제한적 예는 체세포, 심장 섬유아세포, 비-심장 섬유아세포, 심장 전구 세포 및 줄기 세포를 포함한다.
본원에 사용된 바와 같이, "재프로그래밍"은 분화전환, 탈분화 등을 포함한다.
본원에 사용된 바와 같이, 용어 "재프로그래밍 효율"은 샘플 중의 세포의 총 수에 대한, 심근세포로 성공적으로 재프로그래밍된 샘플 중의 세포의 수를 지칭한다.
본원에 사용된 용어 "재프로그래밍 인자(reprogramming factor)"는 한 세포 유형으로부터 다른 세포 유형으로 세포의 재프로그래밍을 지원하기 위해 세포에서 발현을 위해 도입되는 인자를 포함한다. 예를 들면, 재프로그래밍 인자는, 다른 전사 인자 및/또는 소분자와 조합하여, 심장 섬유아세포를 유도된 심근세포로 재프로그래밍할 수 있는 전사 인자를 포함할 수 있다. 문맥상 명백하지 않는 한, 재프로그래밍 인자는 AAV-전달 폴리뉴클레오티드에 의해 암호화될 수 있는 폴리펩티드를 지칭한다. 재프로그래밍 인자에는 소분자도 포함될 수 있다.
용어 "줄기 세포"는, 자가 복제하고 분화된 자손을 생성하는 능력을 갖는 세포를 지칭한다. 용어 "만능 줄기 세포"는 3개 배엽(내배엽, 중배엽 및 외배엽)의 세포를 모두 생성할 수 있지만, 완전한 생물을 생성할 수 있는 능력을 갖지 않는 줄기 세포를 지칭한다.
본원에 사용된 바와 같이, 폴리펩티드 또는 핵산 서열과 관련하여 용어 "이의 등가물"은 참조 폴리펩티드 또는 핵산 서열과는 상이하지만, 본질적 특성(예를 들면, 생물학적 활성)을 보유하는 폴리펩티드 또는 핵산을 지칭한다. 폴리뉴클레오티드의 전형적 변이체는 뉴클레오티드 서열이 또 다른 참조 폴리뉴클레오티드와 상이하다. 변이체의 뉴클레오티드 서열의 변화는 참조 폴리뉴클레오티드에 의해 암호화된 폴리펩티드의 아미노산 서열을 변경하거나 변경하지 않을 수 있다. 뉴클레오티드 변화는, 참조 서열에 의해 암호화된 폴리펩티드에서 아미노산 치환, 결실, 부가, 융합 및 절단을 초래할 수 있다. 일반적으로, 참조 폴리펩티드와 변이체의 서열이 전체적으로 매우 유사하고 다수의 영역에서 동일하도록 차이는 제한된다.
본원에 사용된 바와 같이, 용어 "전구 세포"는, 특정 유형의 세포로 분화하거나 특정 유형의 조직을 형성하도록 약속되어 있는 세포를 지칭한다. 줄기 세포 등의 전구 세포는, 하나 이상의 종류의 세포로 추가로 분화할 수 있지만, 줄기 세포보다 더욱 성숙하기 때문에, 분화 능력이 더욱 제한/한정된다.
용어 "유전적 변형"은, 새로운 핵산(즉, 세포에 대해 외인성 핵산)의 도입 후에 세포에서 유도되는 영구적 또는 일시적 유전적 변화를 지칭한다. 유전적 변화는, 심장 세포의 게놈에 새로운 핵산을 도입하거나, 염색체외 요소로서 새로운 핵산을 일시적 또는 안정적으로 유지함으로써 달성할 수 있다. 세포가 진핵 세포인 경우, 세포의 게놈에 핵산을 도입함으로써 영구적 유전적 변화를 달성할 수 있다. 유전자 변형의 적합한 방법에는 바이러스 감염, 형질감염, 접합, 원형질체 융합, 전기천공, 입자 총 기술, 인산칼슘 침전, 직접 미세주입 등이 포함된다.
용어 "줄기 세포"는, 자가 복제하고 분화된 자손을 생성하는 능력을 갖는 세포를 지칭한다. 용어 "만능 줄기 세포"는 3개 배엽(내배엽, 중배엽 및 외배엽)의 세포를 모두 생성할 수 있지만, 완전한 생물을 생성할 수 있는 능력을 갖지 않는 줄기 세포를 지칭한다. 일부 실시양태에서, 심근세포 표현형을 유도하기 위한 조성물은 재프로그래밍을 유도하기 위해 세포 집단에 사용될 수 있다. 다른 실시양태에서, 조성물은 심근세포 표현형을 유도한다.
용어 "유도 만능 줄기 세포"는 이의 통상의 의미가 부여되어야 하고, 또한 만능성의 적어도 하나의 특성을 나타내도록 재프로그래밍된 분화된 포유동물 체세포(예: 피부 등의 성체 체세포)를 지칭한다[참조: 예를 들면, Takahashi et al. (2007) Cell 131(5):861-872, Kim et al. (2011) Proc. Natl. Acad. Sci. 108(19): 7838-7843, Sell (2013) Stem Cells Handbook].
용어 "형질도입 효율"은 적어도 하나의 AAV 게놈으로 형질도입된 세포의 백분율을 지칭한다. 예를 들면, 1×106 세포가 바이러스에 노출되고 0.5×106 세포가 AAV 게놈의 적어도 하나의 카피를 포함하는 것으로 결정되는 경우, 형질도입 효율은 50%이다. 형질도입 효율을 결정하기 위한 예시적 방법은 유세포 분석법이다. 예를 들면, GFP+ 세포의 백분율은 AAV 게놈이 녹색 형광 단백질(GFP)을 암호화하는 폴리뉴클레오티드를 포함하는 경우의 형질도입 효율의 척도이다.
용어 "선택성"은 한 세포 유형의 다른 세포 유형에 대한 또는 다른 모든 세포 유형에 대한 형질도입 효율의 비율을 지칭한다.
용어 "감염성"은 세포, 특히 생체내 세포를 감염시키는 AAV 비리온의 능력을 지칭한다. 따라서, 감염성은 적어도 생체 분포 및 중화 항체 도피의 함수이다.
달리 명시되지 않는 한, 본 명세서 전체에서 사용된 약어는 다음과 같은 의미를 갖는다: AAV, 아데노-연관 바이러스, rAAV, 재조합 아데노-연관 바이러스; AHCF, 성인 인간 심장 섬유아세포; APCF, 성체 돼지 심장 섬유아세포, α-MHC-GFP; α-미오신 중쇄 녹색 형광 단백질; CF, 심장 섬유아세포; cm, 센티미터; CO, 심박출량; EF, 구출률; FΑCS, 형광 활성화 세포 선별; GFP, 녹색 형광 단백질; GMT, Gata4, Mef2c 및 Tbx5; GMTc, Gata4, Mef2c, Tbx5, TGF-βi, WNTi; GO, 유전자 온톨로지; hCF, 인간 심장 섬유아세포; iCM, 유도 심근세포; kg, 킬로그램; μg, 마이크로그램; μl, 마이크로리터; mg, 밀리그램; ml, 밀리리터; MI, 심근경색증; msec, 밀리초; min, 분; MyAMT, 미오카르딘, Ascl1, Mef2c 및 Tbx5; MyA, 미오카르딘 및 Ascl1; MyMT, 미오카르딘, Mef2c 및 Tbx5; MyMTc, 미오카르딘, Mef2c, Tbx5, TGF-βi, WNTi; MRI, 자기 공명 영상; PBS, 인산염 완충 식염수; PBST, 인산염 완충 식염수, 트리톤; PFA, 파라포름알데히드; qPCR, 정량적 폴리머라제 연쇄 반응; qRT-PCR, 정량적 역전사효소 폴리머라제 연쇄 반응; RNA, 리보핵산; RNA-seq, RNA 서열분석; RT-PCR, 역전사효소 폴리머라제 연쇄 반응; sec, 초; SV, 1회 박출량; TGF-β, 형질전환 성장 인자 베타; TGF-βi, 형질전환 성장 인자 베타 억제제; WNT, wingless-Int; WNTi, wingless-Int 억제제; YFP, 황색 형광 단백질; 4F, Gata4, Mef2c, TBX5 및 미오카르딘; 4Fc, Gata4, Mef2c, TBX5 및 미오카르딘 + TGF-βi 및 WNTi; 7F, Gata4, Mef2c 및 Tbx5, Essrg, 미오카르딘, Zfpm2 및 Mesp1; 7Fc, Gata4, Mef2c 및 Tbx5, Essrg, 미오카르딘, Zfpm2, Mesp1 + TGF-β 및 WNTi.
실시양태 및 변형
조성물
유전자 요법에 유용한 특성을 갖는 캡시드 변이체를 동정하기 위한 노력은 미국 특허 제5,000,000호에 기재된 바와 같이 AAV2 및 AAV5 cap 유전자의 DNA를 셔플링하는 것; 게다가 국제 특허공보 제WO2012/145601A2호 및 제WO2018/222503A1호에 기재된 바와 같은 정향 진화를 포함한다. 이들 문헌의 개시는 모든 목적을 위해, 특히 AAV 비리온의 제조 및 사용 방법, 그 중에 개시된 폴리뉴클레오티드 서열 및 유전자 산물, 뿐만 아니라 심장 질환 또는 장애의 치료에 유용한 전사 인자의 조합을 위해 본원에 도입된다.
AAV 캡시드는 AAV의 cap 유전자에 의해 암호화되고, 이는 우측 개방 판독 프레임(ORF)으로도 지칭된다(좌측 ORF와는 대조적으로, rep). 대표적 AAV 캡시드의 구조는 문헌[참조: Xie et al. (2002) Proc. Natl. Acad. Sci USA 99:10405-1040 (AAV2); Govindasamy et al. (2006) J. Virol. 80:11556-11570 (AAV4); Nam et a. (2007) J. Virol. 81:12260-12271 (AAV8) and Govindasamy et al. (2013) J. Virol. 87:11187-11199 (AAV5)]을 포함하는 다양한 출판물에 기재되어 있다.
AAV 캡시드에는 3개의 바이러스 단백질(VP), VP1, VP2 및 VP3의 60개 카피(합계)가 1:1:10의 예측 비율로 포함되고, T=1 정이십면체 대칭으로 배열되어 있다. 3개의 VP는 동일한 mRNA로부터 번역되고, VP1에는 C-말단 영역의 전체 VP2 서열 외에 고유한 N-말단 도메인이 포함되어 있다. VP2에는 C 말단에 VP3 외에 추가 N 말단 서열이 포함되어 있다. 대부분의 결정 구조에서, 모든 캡시드 단백질(약 530개 아미노산)에 공통하는 C-말단 폴리펩티드 서열만이 관찰된다. VP1의 N-말단 고유 영역, VP1-VP2 중첩 영역 및 VP3의 최초 14~16개의 N-말단 잔기는 주로 무질서한 것으로 생각된다. 저온 전자 현미경 및 이미지 재구성 데이터는 무손상 AAV 캡시드에서 VP1 및 VP2 단백질의 N-말단 영역이 캡시드 내측에 위치하고, 수용체 및 항체 결합에 접근할 수 없음을 시사한다. 따라서, 수용체 부착 및 형질도입 표현형은 일반적으로 VP1, VP2 및 VP3의 공통 C-말단 도메인 내의 아미노산 서열에 의해 결정된다.
일부 실시양태에서, 하나 이상의 아미노산 삽입, 치환 또는 결실은 AAV 캡시드 단백질의 GH 루프 또는 루프 IV, 예를 들면, AAV 캡시드 단백질의 GH 루프 또는 루프 IV의 용매-접근가능한 부분에 있다. AAV 캡시드의 GH 루프/루프 IV에 대해서는, 예를 들면, 문헌[참조: van Vliet et al. (2006) Mol. Ther. 14:809; Padron et al. (2005) Virol. 79:5047; and Shen et al. (2007) Mol. Ther. 15: 1955]을 참조한다. 일부 실시양태에서, "모" AAV 캡시드 단백질은 야생형 AAV5 캡시드 단백질이다. 일부 실시양태에서, "모" AAV 캡시드 단백질은 키메라 AAV 캡시드 단백질이다. 다양한 AAV 캡시드 단백질의 아미노산 서열은 당해 기술분야에 공지되어 있다[참조: 예를 들면, AAV1에 대한 GenBank 수탁 번호 NP_049542; AAV4에 대한 GenBank 수탁 번호 NP_044927; AAV5에 대한 GenBank 수탁 번호 AAD13756; AAV6에 대한 GenBank 수탁 번호 AAB95450; AAV7에 대한 GenBank 수탁 번호 YP_077178; AAV 8에 대한 GenBank 수탁 번호 YP_077180; AAV9에 대한 GenBank 수탁 번호 AAS99264 및 AAV10에 대한 GenBank 수탁 번호 AAT46337]. 예측된 선조 AAV 캡시드에 대해서는 문헌[참조: 예를 들면, Santiago-Ortiz et al. (2015) Gene Ther. 22:934]을 참조한다.
아데노-연관 바이러스(AAV)는 복제-결함 파보바이러스이고, 이의 일본쇄 DNA 게놈의 길이는 약 4.7kb이고, 2개의 145개 뉴클레오티드 역방향 말단 반복서열(ITR)을 포함한다. AAV에는 복수의 혈청형이 있다. AAV 혈청형의 게놈의 뉴클레오티드 서열은 공지되어 있다. 예를 들면, AAV5 게놈은 GenBank 수탁 번호 AF085716에서 제공된다. AAV의 라이프 사이클 및 유전학은 문헌[참조: Muzyczka, Current Topics in Microbiology and Immunology, 158: 97-129(1992)]에서 개설되어 있다. 유사형 rAAV의 생산은, 예를 들면, 제WO 01/83692호에 개시되어 있다. 다른 유형의 rAAV 변이체, 예를 들면, 캡시드 돌연변이를 갖는 rAAV도 고려된다[참조: 예를 들면, Marsic et al., Molecular Therapy, 22(11): 1900-1909(2014)]. 예시적 AAV 벡터는 US 7,105,345; US 15/782,980; US 7,259,151; US 6,962,815; US 7,718,424; US 6,984,517; US 7,718,424; US 6,156,303; US 8,524,446; US 7,790,449; US 7,906,111; US 9,737,618; US 출원번호 15/433,322; US 7,198,951에서 제공되고, 각각은 모든 목적을 위해 그 전체가 참조에 의해 도입된다.
본 개시의 rAAV 비리온은 하나 이상의 유전자 산물을 암호화하는 뉴클레오티드 서열을 포함하는 이종 핵산을 포함한다. 유전자 산물(들)은 폴리펩티드 또는 RNA, 또는 이들 둘 다일 수 있다. 유전자 산물이 폴리펩티드인 경우, 뉴클레오티드 서열은, 임의로 하나 이상의 인트론과 함께 메신저 RNA를 암호화하고, 이는 유전자 산물 폴리펩티드로 번역된다. 뉴클레오티드 서열은 1개, 2개, 3개 또는 그 이상의 유전자 산물을 암호화할 수 있다(여기서, 그 수는 rAAV 비리온의 패키징 용량에 의해 제한되지만, 통상은 약 5.2kb임). 유전자 산물은 하나의 프로모터(단일 전사 단위의 경우) 또는 하나 이상의 프로모터에 작동가능하게 연결될 수 있다. 다중 유전자 산물은, 내부 리보솜 진입 신호(IRES) 또는 자가 절단 펩티드(예: 2A 펩티드)를 사용하여 생산할 수도 있다.
일부 실시양태에서, 유전자 산물은 폴리펩티드이다. 일부 실시양태에서, 폴리펩티드 유전자 산물은, 유도 심근세포-유사 세포(iCM)를 생성하기 위해, 심장 섬유아세포의 재프로그래밍을 유도하는 폴리펩티드이다. 일부 실시양태에서, 폴리펩티드 유전자 산물은 심장 세포의 기능을 증강시키는 폴리펩티드이다. 일부 실시양태에서, 폴리펩티드 유전자 산물은 심장 세포에서 결손되거나 결손된 기능을 제공하는 폴리펩티드이다. 일부 실시양태에서, 폴리펩티드 유전자 산물은 게놈-편집 엔도뉴클레아제이다.
일부 실시양태에서, 유전자 산물은 이종 폴리펩티드에 융합된 융합 단백질을 포함한다. 일부 실시양태에서, 유전자 산물은 세포내 국재화를 제공하는 아미노산 서열에 융합된 게놈 편집 뉴클레아제를 포함하고, 즉, 융합 파트너는 세포내 국재화 서열(예를 들면, 핵을 표적화하는 하나 이상의 핵 국재화 신호(NLS), 2개 이상의 NLS, 3개 이상의 NLS 등)이다.
일반적으로, 바이러스 벡터는 바이러스 DNA 또는 RNA 작제물을 "생산자 세포" 또는 "패키징 세포" 계통에 도입함으로써 생산된다. 패키징 세포주에는 용이하게 형질전환될 수 있는 세포주가 포함되지만, 이들로 한정되지 않는다. 패키징 세포주는 HEK291, 293T 세포, NIH3T3, COS, HeLa 또는 Sf9 세포주를 기반으로 할 수 있다. 패키징 세포주의 예에는 Sf9(ATCC® CRL-1711™)가 포함되지만, 이들로 한정되지 않는다. rAAV 비리온을 생성하기 위한 예시적 패키징 세포주 및 방법은 국제 공개공보 WO2017075627, WO2015/031686, WO2013/063379, WO2011/020710, WO2009/104964, WO2008/024998, WO2003/042361, 및 WO1995/013392; 미국 특허 US9441206B2, US8679837, 및 US7091029B2에 의해 제공된다.
일부 실시양태에서, 유전자 산물은 기능적 심장 단백질이다. 일부 실시양태에서, 유전자 산물은 비-기능적 심장 단백질을 기능적 심장 단백질로 치환하거나 수복하는 게놈-편집 엔도뉴클레아제(임의로 가이드 RNA, 단일-가이드 RNA, 및/또는 수복 주형을 수반함)이다. 기능적 심장 단백질에는 심장 트로포닌 T; 심장 근육 단백질; β-미오신 중쇄; 미오신 심실 필수 경쇄 1; 미오신 심실 조절 경쇄 2; 심장 α-액틴; α-트로포미오신; 심장 트로포닌 I; 심장 미오신 결합 단백질 C; 4.5 LIM 단백질 1; 티틴; 5'-AMP 활성화 단백질 키나제 서브유닛 감마-2; 트로포닌 I 유형 3, 미오신 경쇄 2, 액틴 알파 심장 근육 1; 심장 LIM 단백질; 카베올린 3(CAV3); 갈락토시다제 알파(GLA); 리소좀-관련 막 단백질 2(LAMP2); 미토콘드리아 전달 RNA 글리신(MTTG); 미토콘드리아 전달 RNA 이소류신(MTTI); 미토콘드리아 전달 RNA 라이신(MTTK); 미토콘드리아 전달 RNA 글루타민(MTTQ); 미오신 경쇄 3(MYL3); 트로포닌 C(TNNC1); 트랜스티레틴(TTR); 근소포체 칼슘-ATPase 2a(SERCA2a); 간질 유래 인자-1(SDF-1); 아데닐레이트 사이클라제-6(AC6); β-ARKct(β-아드레날린 수용체 키나제 C 말단); 섬유아세포 성장 인자(FGF); 혈소판 유래 성장 인자(PDGF); 혈관 내피 성장 인자(VEGF); 간세포 성장 인자; 저산소증 유도성 성장 인자; 티모신 베타 4(TMSB4X); 산화질소 신타제-3(NOS3); 아포리포단백질-E(ApoE); 및 슈퍼옥사이드 디스뮤타제(SOD); S100A1(작은 칼슘 결합 단백질; 참조, 예를 들면, Ritterhoff and Most (2012) Gene Ther. 19:613; Kraus et al. (2009) Mol. Cell. Cardiol. 47:445)을 포함하지만, 이들로 한정되지 않는다.
일부 실시양태에서, 유전자 산물은 그 발현이 유전적 장애를 유발하는 유전자의 결함을 보완하는 유전자 산물이다. 본 개시는 다음 중 하나 이상을 암호화하는 폴리뉴클레오티드를 포함하는 rAAV 비리온을 제공한다 - 예를 들면, 제한 없이, 괄호에 표시된 장애 또는 각각에 의해 유발된 다른 장애에서 사용하기 위한: TAZ(바르트 증후군(Barth syndrome)); FXN(프리드리히 운동실조증(Freidrich's Ataxia)); CASQ2(CPVT); FBN1(마르판(Marfan)); RAF1 및 SOS1(누난(Noonan)); SCN5A(브루가다(Brugada)); KCNQ1 및 KCNH2(긴 QT 증후군(Long QT Syndrome)); DMPK(근긴장성 이영양증 1(Myotonic Dystrophy 1)); LMNA(사지 거들 이영양증 유형 1B(Limb Girdle Dystrophy Type 1B)); JUP(낙소스(Naxos)); TGFBR2(로이스-디에츠(Loeys-Dietz)); EMD(X-연결 EDMD); 및 ELN(SV 대동맥 협착증(SV Aortic Stenosis)). 일부 실시양태에서, rAAV 비리온은 심장 트로포닌 T(TNNT2); BAG 패밀리 분자 샤페론 조절인자 3(BAG3); 미오신 중쇄(MYH7); 트로포미오신 1(TPM1); 미오신 결합 단백질 C(MYBPC3); 5'-AMP-활성화 단백질 키나제 서브유닛 감마-2(PRKAG2); 트로포닌 I 유형 3(TNNI3); 티틴(TTN); 미오신, 경쇄 2(MYL2); 액틴, 알파 심근 1(ACTC1); 칼륨 전압-게이트 채널, KQT-유사 서브패밀리, 멤버 1(KCNQ1); 플라코필린 2(PKP2); 근세포 인핸서 인자 2c(MEF2C); 및 심장 LIM 단백질(CSRP3) 중 하나 이상을 암호화하는 폴리뉴클레오티드를 포함한다.
일부 실시양태에서, 본 개시의 유전자 산물은 폴리펩티드 재프로그래밍 인자이다. 한 세포 유형을 또 다른 세포 유형으로 전환하는 수단으로서, 재프로그래밍 인자가 바람직한다. 비-심근세포 세포는 당업자에게 이용가능한 임의의 방법을 사용하여 시험관내 또는 생체내에서 심근세포로 분화시킬 수 있다. 예를 들면, 문헌[참조: Ieda et al. (2010) Cell 142:375-386; Christoforou et al. (2013) PLoS ONE 8:e63577; Addis et al. (2013) J. Mol. Cell Cardiol. 60:97-106; Jayawardena et al. (2012) Circ. Res. 110: 1465-1473; Nam Y et al. (2003) PNAS USA 110:5588-5593; Wada R et al. (2013) PNAS USA 110: 12667-12672; and Fu J et al. (2013) Stem Cell Reports 1:235-247]에 기재된 방법을 참조한다.
심장의 맥락에서, 재프로그래밍 인자는, 직접 또는 중간 세포 유형을 통해, 심장 섬유아세포를 심근 세포로 전환할 수 있다. 특히, 직접 재프로그래밍이 가능하거나, 최초로 섬유아세포를 만능성 또는 전능성 줄기 세포로 전환함으로써 재프로그래밍할 수 있다. 이러한 만능 줄기 세포는 유도 만능 줄기 세포(iPS)라고 한다. 이후에, 심근 세포(CM) 세포로 전환되는 iPS 세포는 iPS-CM 세포라고 한다. 예에서, 심장 섬유아세포로부터 시험관내에서 유도된 iPS-CM을 생체내에서 사용하여, 목적 캡시드 단백질을 선택한다. 본 개시는 또한, 캡시드 단백질 개시를 사용하여, 시험관내에서, 특히 생체내에서 치료 유전자 요법 섭생의 일부로서 iPS-CM 세포를 생성하는 것을 상정한다. 유도 심근세포-유사(iCM) 세포는 심근세포로 직접 재프로그래밍된 세포를 지칭한다.
유도된 심근세포는 하나 이상의 심근세포 특이적 마커를 발현하고, 여기서 심근세포 특이적 마커에는 심장 트로포닌 I, 심장 트로포닌-C, 트로포미오신, 카베올린-3, 미오신 중쇄, 미오신 경쇄-2a, 미오신 경쇄-2v, 리아노딘 수용체, 사르코머 α-액티닌, Nkx2.5, 코넥신 43 및 심방 나트륨 이뇨 인자가 포함되지만, 이들로 한정되지 않는다. 유도된 심근세포는 또한 근절 구조를 나타낼 수 있다. 유도된 심근세포는 심근세포 특이적 유전자 ACTC1(심장 α-액틴), ACTN2(액티닌 α2), MYH6(α-미오신 중쇄), RYR2(리아노딘 수용체 2), MYL2(미오신 조절 경쇄 2, 심실 동형), MYL7(미오신 조절 경쇄, 심방 동형), TNNT2(트로포닌 T 유형 2, 심장) 및 NPPA(나트륨 이뇨 펩티드 전구체 유형 A), PLN(포스포람반)의 발현 증가를 나타낸다. Colla2(콜라겐 la2) 등의 섬유아세포 마커의 발현은 iCM이 유래된 섬유아세포와 비교하여 유도된 심근세포에서 하향조절된다.
폴리펩티드 재프로그래밍 인자(일부 경우에, rAAV와 조합하여 공급되는 소분자 재프로그래밍 인자에 의해 보충됨)를 포함하는 재프로그래밍 방법은, 특히 개시된 재프로그래밍 방법 및 인자를 위해 전체가 도입되는, US2018/0112282A1, WO2018/005546, WO2017/173137, US2016/0186141, US2016/0251624, US2014/0301991, 및 US2013/0216503A1에 기재된 것들을 포함한다.
일부 실시양태에서, 심장 세포는, 아카에트-스큐트 호모로그(Achaete-scute homolog) 1(ASCL1), 미오카르딘(Myocardin)(MYOCD), 근세포-특이적 인핸서 인자 2C(MEF2C) 및/또는 T-박스 전사 인자 5(TBX5) 등의 하나 이상의 목적 폴리펩티드 또는 단백질의 발현을 조절하는 하나 이상의 재프로그래밍 인자를 사용하여 유도 심근세포-유사(iCM) 세포로 재프로그래밍된다. 일부 실시양태에서, 하나 이상의 재프로그래밍 인자는 하나 이상의 목적 폴리뉴클레오티드 또는 단백질을 암호화하는 폴리뉴클레오티드(예를 들면, RNA, mRNA, 또는 DNA 폴리뉴클레오티드)로서 제공된다. 일부 실시양태에서, 하나 이상의 재프로그래밍 인자는 단백질로서 제공된다.
일부 실시양태에서, 재프로그래밍 인자는 마이크로RNA 또는 마이크로RNA 길항제, siRNA, 또는 하나 이상의 목적 폴리뉴클레오티드 또는 단백질의 발현을 증가시킬 수 있는 소분자이다. 일부 실시양태에서, 목적 폴리뉴클레오티드 또는 단백질의 발현은 마이크로RNA 또는 마이크로RNA 길항제의 발현에 의해 증가된다. 예를 들면, Oct 폴리펩티드의 내인성 발현은 microRNA-302(miR-302)의 도입 또는 miR-302의 발현의 증가에 의해 증가될 수 있다[참조: 예를 들면, Hu et al., Stem Cells 31(2): 259-68(2013), 이는 참조에 의해 그 전체가 본원에 도입된다]. 따라서, miRNA-302는 내인성 Oct 폴리펩티드 발현의 유도인자가 될 수 있다. miRNA-302는 단독으로 또는 Oct 폴리펩티드를 암호화하는 핵산과 함께 도입될 수 있다. 일부 실시양태에서, 적합한 핵산 유전자 산물은 마이크로RNA이다. 적합한 micrRNA에는, 예를 들면, mir-1, mir-133, mir-208, mir-143, mir-145 및 mir-499가 포함된다.
일부 실시양태에서, 본 개시의 방법은 소분자 재프로그래밍 인자의 투여 전, 투여 동안 또는 투여 후에, 본 개시의 rAAV 비리온을 투여하는 것을 포함한다. 일부 실시양태에서, 소분자 재프로그래밍 인자는 SB431542, LDN-193189, 덱사메타손, LY364947, D4476, 미리세틴, IWR1, XAV939, 도코사헥사엔산(DHA), S-니트로소-TV-아세틸페니실라민(SNAP), Hh-Agl.5, 알프로스타딜, 크로마칼림, MNITMT, A769662, 레티노산 p-하이드록시아닐라이드, 데카메토늄 디브로마이드, 니페디핀, 피록시캄, 바시트라신, 아즈트레오남, 하르마롤 하이드로클로라이드, 아미드-C2(A7), Ph-C12(CIO), mCF3-C-7(J5), G856-7272(A473), 5475707, 또는 이의 임의의 조합으로 이루어진 그룹으로부터 선택된 소분자이다.
일부 실시양태에서, 유전자 산물은 ASCL1, MYOCD, MEF2C 및 TBX5로부터 선택된 하나 이상의 목적 단백질의 발현을 조절하는 재프로그래밍 인자를 포함한다. 일부 실시양태에서, 유전자 산물은 ASCL1, MYOCD, MEF2C, 및 TBX5, CCNB1, CCND1, CDK1, CDK4, AURKB, OCT4, BAF60C, ESRRG, GATA4, GATA6, HAND2, IRX4, ISLL, MESP1, MESP2, NKX2.5, SRF, TBX20, ZFPM2 및 miR-133으로부터 선택된 하나 이상의 재프로그래밍 인자를 포함한다.
일부 실시양태에서, 유전자 산물은 GATA4, MEF2C 및 TBX5(즉, GMT)를 포함한다. 일부 실시양태에서, 유전자 산물은 MYOCD, MEF2C 및 TBX5(즉, MyMT)를 포함한다. 일부 실시양태에서, 유전자 산물은 MYOCD, ASCL1, MEF2C 및 TBX5(즉, MyAMT)를 포함한다. 일부 실시양태에서, 유전자 산물은 MYOCD 및 ASCL1(즉, MyA)을 포함한다. 일부 실시양태에서, 유전자 산물은 GATA4, MEF2C, TBX5 및 MYOCD(즉, 4F)를 포함한다. 다른 실시양태에서, 유전자 산물은 GATA4, MEF2C, TBX5, ESSRG, MYOCD, ZFPM2, 및 MESP1(즉, 7F)을 포함한다. 일부 실시양태에서, 유전자 산물은 ASCL1, MEF2C, GATA4, TBX5, MYOCD, ESRRG 및 MESPL 중 하나 이상을 포함한다.
일부 실시양태에서, rAAV 비리온은 시험관내 또는 생체내에서 심장 근육세포를 생성한다. 심근세포 또는 심근 세포는 심장 근육을 구성하는 근육 세포이다. 각 심근 세포에는 근육 세포의 수축 단위인 사르코머의 장쇄인 근원섬유가 포함된다. 심근 세포는 골격근 세포와 유사한 줄무늬를 나타내지만, 다핵 골격 세포와는 달리 하나의 핵만이 함유되어 있다. 심근세포는 미토콘드리아 밀도가 높기 때문에, ATP를 신속하게 생성할 수 있어 피로에 대한 내성이 높아진다. 성숙한 심근세포는 α-액티닌, MLC2v, MY20, cMHC, NKX2-5, GATA4, cTNT, cTNI, MEF2C, MLC2a 또는 이들의 임의의 조합의 심장 마커 중 하나 이상을 발현할 수 있다. 일부 실시양태에서, 성숙한 심근세포는 NKX2-5, MEF2C 또는 이들의 조합을 발현한다. 일부 실시양태에서, 심장 전구 세포는 GATA4, ISL1 또는 이들의 조합 등의 초기 단계의 심장 전구 마커를 발현한다.
일부 실시양태에서, 유전자 산물은 폴리뉴클레오티드이다. 일부 실시양태에서, 하기에 기재된 바와 같이, 유전자 산물은 RNA-유도 엔도뉴클레아제에 결합할 수 있는 가이드 RNA이다. 일부 실시양태에서, 유전자 산물은, 예를 들면, 심장 세포에서 mRNA 및/또는 폴리펩티드 유전자 산물의 수준을 감소시킬 수 있는 억제 핵산이다. 예를 들면, 일부 실시양태에서, 폴리뉴클레오티드 유전자 산물은, 심장 질환 또는 장애를 유발하는 대립유전자에 의해 암호화된 전사물을 선택적으로 불활성화시킬 수 있는 간섭 RNA이다. 예를 들면, 대립유전자는, 비대성 심근병증-유발 돌연변이를 포함하는 미오신 중쇄 7, 심근, 베타(MYH7) 대립유전자이다. 다른 예는, 예를 들면, 비대성 심근병증(HCM), 확장성 심근병증(DCM) 또는 좌심실 비압축(LVNC)을 유발하는 대립유전자에 의해 암호화된 전사물을 선택적으로 비활성화하는 간섭 RNA를 포함하고, 여기서 대립유전자는 MYL3(미오신 경쇄 3, 알칼리, 심실, 느린 골격), MYH7, TNNI3(트로포닌 I 유형 3(심장)), TNNT2(트로포닌 T 유형 2(심장)), TPM1(트로포미오신 1(알파)) 또는 HCM 유발, DCM 유발 또는 LVNC 유발 돌연변이를 포함하는 ACTCl 대립유전자이다[참조: 예를 들면, 심장 질환을 유발하는 돌연변이의 예에 대해서는 미국 특허공보 제2016/0237430호].
일부 실시양태에서, 유전자 산물은 폴리펩티드-암호화 RNA이다. 일부 실시양태에서, 유전자 산물은 간섭 RNA이다. 일부 실시양태에서, 유전자 산물은 앱타머이다. 일부 실시양태에서, 유전자 산물은 폴리펩티드이다. 일부 실시양태에서, 유전자 산물은 치료용 폴리펩티드, 예를 들면, 임상적 이점을 제공하는 폴리펩티드이다. 일부 실시양태에서, 유전자 산물은 유전자 기능의 부위-특이적 녹다운을 제공하는 부위-특이적 뉴클레아제이다. 일부 실시양태에서, 유전자 산물은 표적 핵산의 변형을 제공하는 RNA-유도 엔도뉴클레아제이다. 일부 실시양태에서, 유전자 산물은, i) 표적 핵산의 변형을 제공하는 RNA-유도 엔도뉴클레아제; 및 ii) 표적 핵산 중의 표적 서열에 결합하는 제1 세그먼트 및 RNA-유도 엔도뉴클레아제에 결합하는 제2 세그먼트를 포함하는 가이드 RNA이다. 일부 실시양태에서, 유전자 산물은 i) 표적 핵산의 변형을 제공하는 RNA-유도 엔도뉴클레아제; ii) 표적 핵산 내의 제1 표적 서열에 결합하는 제1 세그먼트 및 RNA-유도 엔도뉴클레아제에 결합하는 제2 세그먼트를 포함하는 제1 가이드 RNA; 및 iii) 표적 핵산 내의 제2 표적 서열에 결합하는 제1 세그먼트 및 RNA-유도 엔도뉴클레아제에 결합하는 제2 세그먼트를 포함하는 제1 가이드 RNA이다.
본 개시의 rAAV 비리온에서 이종 유전자 산물을 암호화하는 뉴클레오티드 서열은 프로모터에 작동가능하게 연결될 수 있다. 예를 들면, 본 개시의 rAAV 비리온에서 이종 유전자 산물을 암호화하는 뉴클레오티드 서열은 구성적 프로모터, 조절가능한 프로모터, 또는 심장 세포-특이적 프로모터에 작동가능하게 연결될 수 있다. 적합한 구성적 프로모터는 인간 신장 인자 1α 서브유닛(EF1α) 프로모터, β-액틴 프로모터, α-액틴 프로모터, β-글루쿠로니다제 프로모터, CAG 프로모터, 슈퍼 코어 프로모터, 및 유비퀴틴 프로모터를 포함한다. 일부 실시양태에서, 본 개시의 rAAV 비리온에서 이종 유전자 산물을 암호화하는 뉴클레오티드 서열은 심장-특이적 전사 조절 인자(TRE)에 작동가능하게 연결되고, 여기서 심장-특이적 TRE는 프로모터 및 인핸서를 포함한다. 적합한 심장 특이적 TRE는 하기 유전자로부터 유래된 TRE를 포함하지만, 이들로 한정되지 않는다: 미오신 경쇄-2(MLC-2), α-미오신 중쇄(α-MHC), 데스민, AE3, 심장 트로포닌 C(cTnC) 및 심장 액틴[참조: Franz et al. (1997) Cardiovasc. Res. 35:560-566; Robbins et al. (1995) Ann. NY. Acad. Sci. 752:492-505; Linn et al. (1995) Circ. Res. 76:584-591; Parmacek et al. (1994) Mol. Cell. Biol. 14: 1870-1885; Hunter et al. (1993) Hypertension 22:608-617; and Sartorelli et al. (1992) Proc. Natl. Acad. Sci. USA 89:4047-4051. See also, Pacak et al. (2008) Genet Vaccines Ther. 6:13]. 일부 실시양태에서, 프로모터는 α-MHC 프로모터, MLC-2 프로모터, 또는 cTnT 프로모터이다.
유전자 산물을 암호화하는 폴리뉴클레오티드는 유전자 산물의 발현을 촉진하기 위해 프로모터 및/또는 인핸서에 작동가능하게 연결된다. 사용되는 숙주/벡터 시스템에 따라, 구성적 및 유도성 프로모터, 전사 인핸서 요소, 전사 종결인자자 등을 포함하는, 다수의 적합한 전사 및 번역 제어 요소 중 어느 하나를 rAAV 비리온에서 사용할 수 있다[참조: Bitter et al. (1987) Methods in Enzymology, 153:516-544].
각각의 폴리뉴클레오티드에 대해 별개의 프로모터 및/또는 인핸서를 사용할 수 있다. 일부 실시양태에서, 동일한 프로모터 및/또는 인핸서가 단일 개방 판독 프레임에서 2개 이상의 폴리뉴클레오티드에 사용된다. 이러한 구성의 유전 요소를 사용하는 벡터는 "폴리시스트론"이라고 한다. 폴리시스트론 벡터의 예시적 예는, 2A 영역(들)에 의해 연결된 2개 이상의 폴리뉴클레오티드를 포함하는 단일 개방-판독 프레임에 작동적으로 연결된 인핸서 및 프로모터를 포함하고, 이에 의해 개방-판독 프레임의 발현은 복수의 폴리펩티드가 동시-번역적으로 생성되게 한다. 2A 영역은 코돈 스키핑을 통해 복수의 폴리펩티드 서열의 생성을 매개하는 것으로 믿어지고; 그러나, 본 개시는 또한, 번역후 절단을 사용하여, 동일한 폴리뉴클레오티드로부터 2개 이상의 목적 단백질을 생성하는 폴리시스트론 벡터에 관한 것이다. 예시적 2A 서열, 벡터 및 관련 방법은 US20040265955A1에 제공되어 있고, 이는 참조에 의해 본원에 도입된다.
적합한 진핵생물 프로모터(진핵생물 세포에서 기능하는 프로모터)의 비제한적 예에는 CMV, CMV 즉시 초기, HSV 티미딘 키나제, 초기 및 후기 SV40, 레트로바이러스로부터의 긴 말단 반복서열(LTR), 및 마우스 메탈로티오네인-I이 포함된다. 일부 실시양태에서, 심장 특이적 발현을 부여할 수 있는 프로모터가 사용될 것이다. 적합한 심장 특이적 프로모터의 비제한적 예는 데스민(Des), 알파-미오신 중쇄(α-MHC), 미오신 경쇄 2(MLC-2), 심장 트로포닌 T(cTnT) 및 심장 트로포닌 C(cTnC)를 포함한다. 적합한 뉴런 특이적 프로모터의 비제한적 예는 시냅신 I(SYN), 칼슘/칼모듈린 의존성 단백질 키나제 II, 튜불린 알파 I, 뉴런 특이적 에놀라제 및 혈소판 유래 성장 인자 베타 쇄 프로모터 및 사이토메갈로바이러스 인핸서(E)를 이들 뉴런 특이적 프로모터에 융합함으로써 하이브리드 프로모터를 포함한다.
발현 재프로그래밍 인자를 구동하기 위한 적합한 프로모터의 예는 레트로바이러스 긴 말단 반복서열(LTR) 요소; CMV, HSV1-TK, SV40, EF-1a, β-액틴, 포스포글리세롤 키나제(PGK) 등의 구성적 프로모터; Tet-오퍼레이터 요소를 포함하는 것 등의 유도성 프로모터; 데스민(DES), 알파-미오신 중쇄(a-MHC), 미오신 경쇄 2(MLC-2), 심장 트로포닌 T(cTnT) 및 심장 트로포닌 C(cTnC) 등의 심장 특이적 프로모터; 네스틴, 뉴런 핵(NeuN), 미세소관-연관 단백질 2(MAP2), 베타 III 튜불린, 뉴런 특이적 에놀라제(NSE), 올리고덴드로사이트 계통(Oligl/2) 및 글리아 섬유성 산성 단백질(GFAP) 등의 신경 특이적 프로모터; 및 Pax4, Nkx2.2, Ngn3, 인슐린, 글루카곤 및 소마토스타틴 등의 췌장 특이적 프로모터를 포함하지만, 이들로 한정되지 않는다.
일부 실시양태에서, 폴리뉴클레오티드는 세포 유형-특이적 전사 조절 요소(TRE)에 작동가능하게 연결되며, 여기서 TRE는 프로모터 및 인핸서를 포함한다. 적합한 TRE는 하기 유전자로부터 유래하는 TRE가 포함되지만, 이들로 한정되지 않는다: 미오신 경쇄-2, α-미오신 중쇄, AE3, 심장 트로포닌 C 및 심장 액틴 유전자[참조: Franz et al. (1997) Cardiovasc. Res. 35:560-566; Robbins et al. (1995) Ann. N. Y. Acad. Sci. 752:492-505; Linn et al. (1995) Circ. Res. 76:584-591; Parmacek et al. (1994) Cell. Biol. 14:1870-1885; Hunter et al. (1993) Hypertension 22:608-617; and Sartorelli et al. (1992) PNAS USA 89:4047-4051].
프로모터는, 유전자 또는 핵산 세그먼트와 자연적으로 연관된 것일 수 있다. 유사하게, RNA(예를 들면, 마이크로RNA)의 경우, 프로모터는 마이크로RNA 유전자(예를 들면, miRNA-302 유전자)와 자연적으로 연관된 것일 수 있다. 이러한 천연적으로 결합된 프로모터는 "천연 프로모터(natural promoter)"로 지칭될 수 있고, 코딩 세그먼트 및/또는 엑손의 상류에 위치한 5' 비-코딩 서열을 단리함으로써 수득될 수 있다. 유사하게, 인핸서는 핵산 서열과 자연적으로 연관된 것일 수 있다. 그러나, 인핸서는 해당 서열의 하류 또는 상류에 위치할 수 있다.
또는, 특정 이점은, 재조합 또는 이종 프로모터의 조절하에 코딩 핵산 세그먼트를 위치시킴으로써 수득될 수 있고, 이는 통상 자연 환경에서 핵산과 연관되지 않는 프로모터를 지칭한다. 재조합 또는 이종 인핸서는 또한 자연 환경에서 핵산 서열과 통상 연관되지 않는 인핸서를 지칭한다. 이러한 프로모터 또는 인핸서는, 다른 유전자의 프로모터 또는 인핸서, 및 임의의 기타 원핵생물, 바이러스 또는 진핵생물 세포로부터 단리된 프로모터 또는 인핸서, 및 "천연 발생"이 아닌, 즉 상이한 전사 조절 영역의 상이한 요소, 및/또는 발현을 변경하는 돌연변이를 함유하는 프로모터 또는 인핸서를 포함할 수 있다. 프로모터 및 인핸서의 핵산 서열을 합성적으로 생성하는 것 외에도, 서열은, 본원에 개시된 조성물과 관련하여, 재조합 클로닝 및/또는 PCR™을 포함한 핵산 증폭 기술을 사용하여 생성될 수 있다(미국 특허 제4,683,202호, 미국 특허 제5,928,906호, 각각은 참조에 의해 본원에 도입됨).
사용된 프로모터는 구성적, 유도성, 발생 특이적, 조직 특이적 및/또는 핵산 세그먼트의 고수준 발현을 지시하기 위한 적절한 조건하에서 유용할 수 있다. 예를 들면, 프로모터는, CMV 프로모터, CMV 사이토메갈로바이러스 즉시 초기 프로모터, CAG 프로모터, EF-1α 프로모터, HSV1-TK 프로모터, SV40 프로모터, β-액틴 프로모터, PGK 프로모터, 또는 이들의 조합 등의 구성적 프로모터일 수 있다. 사용될 수 있는 진핵생물 프로모터의 예에는 구성적 프로모터, 예를 들면, CMV, SV40 및 RSV 프로모터 등의 바이러스 프로모터, 게다가 조절 가능한 프로모터, 예를 들면, 유도성 또는 억제성 프로모터, 예를 들면, tet 프로모터, hsp70 프로모터 및 CRE에 의해 조절되는 합성 프로모터를 포함하지만, 이들로 한정되지 않는다. 특정 실시양태에서, 세포 유형-특이적 프로모터는 특정 세포 유형에서 재프로그래밍 인자의 발현을 유도하기 위해 사용된다. 본원에 기재된 방법에 유용한 적합한 세포 유형-특이적 프로모터의 예는 문헌[참조: He et al (2006), Human Gene Therapy 17:949-959]에 기재된 합성 마크로파지-특이적 프로모터; 과립구 및 마크로파지-특이적 리소자임 M 프로모터[참조: 예를 들면, Faust et al (2000), Blood 96(2):719-726], 및 골수-특이적 CD11b 프로모터[참조: 예를 들면, Dziennis et al (1995), Blood 85(2):319-329]를 포함하지만, 이들로 한정되지 않는다. 사용될 수 있는 프로모터의 기타 예에는 인간 EF1α 신장 인자 프로모터, CMV 사이토메갈로바이러스 즉시 초기 프로모터, CAG 치킨 알부민 프로모터, 본원에 기재된 임의의 바이러스 벡터와 관련된 바이러스 프로모터, 또는 본원에 기재된 임의의 프로모터(예를 들면, 다른 종으로부터)와 상동성인 프로모터가 포함된다. 사용될 수 있는 원핵생물 프로모터의 예에는 SP6, T7, T5, tac, bla, trp, gal, lac 또는 말토스 프로모터가 포함되지만, 이들로 한정되지 않는다.
일부 실시양태에서, 내부 리보솜 진입 부위(IRES) 요소를 사용하여 다중유전자 또는 폴리시스트론 메시지를 생성할 수 있다. IRES 요소는 5'-메틸화된 Cap 의존성 번역의 리보솜 스캐닝 모델을 바이패스하고, 내부 부위에서 번역을 개시할 수 있다[참조: Pelletier and Sonenberg, Nature 334(6180):320-325(1988)]. 피코르나바이러스 패밀리의 2개 멤버(폴리오 및 뇌심근염)으로부터의 IRES 요소[참조: Pelletier and Sonenberg, Nature 334(6180):320-325(1988)], 및 포유류 메시지로부터의 IRES[참조: Macejak & Samow, Nature 353:90-94(1991)]가 기재되어 있다. IRES 요소는 이종 개방 판독 프레임에 연결될 수 있다. 복수의 개방 판독 프레임을 함께 전사할 수 있고, 각각은 IRES에 의해 분리되어 폴리시스트론 메시지를 생성한다. IRES 요소 덕분에, 각 개방 판독 프레임은 효율적 번역을 위해 리보솜에 액세스할 수 있다. 단일 프로모터/인핸서를 사용하여 다중 유전자를 효율적으로 발현시켜 단일 메시지를 전사할 수 있다(참조에 의해 본원에 도입된 미국 특허 제5,925,565호 및 제5,935,819호 참조).
일부 실시양태에서, 뉴클레오티드 서열은 폴리아데닐화 서열에 작동가능하게 연결된다. 적합한 폴리아데닐화 서열은 소 성장 호르몬 폴리A 신호(bGHpolyA) 및 짧은 폴리 A 신호를 포함한다. 임의로, 본 개시의 rAAV 벡터는 우드척 전사후 조절 요소(WPRE)를 포함한다. 일부 실시양태에서, 유전자 산물을 암호화하는 폴리뉴클레오티드는 소위 자가-절단 펩티드, 예를 들면, P2A 펩티드를 포함하는 서열에 의해 연결된다.
일부 실시양태에서, 유전자 산물은 유전자 기능의 부위-특이적 녹다운을 제공하는 부위-특이적 엔도뉴클레아제를 포함하고, 예를 들면, 엔도뉴클레아제는 심장 질환 또는 장애와 관련된 대립유전자를 녹아웃시킨다. 예를 들면, 우성 대립유전자가, 야생형인 경우, 심장 구조 단백질이고/거나, 정상 심장 기능을 제공하는 유전자의 결함 카피를 암호화하는 경우, 부위 특이적 엔도뉴클레아제는 결함 대립유전자를 표적화하여 겸함 대립유전자를 녹아웃시킬 수 있다. 일부 실시양태에서, 부위-특이적 엔도뉴클레아제는 RNA-유도 엔도뉴클레아제이다.
결함 대립유전자를 녹아웃시키는 것 외에도, 부위 특이적 뉴클레아제를 사용하여, 결함 대립유전자에 의해 암호화된 단백질의 기능적 카피를 암호화하는 공여자 DNA와의 상동 재조합을 자극할 수도 있다. 예를 들면, 대상 rAAV 비리온을 사용하여, 결함 대립유전자를 녹아웃시키는 부위-특이적 엔도뉴클레아제와 결함 대립유전자(또는 이의 단편)의 기능적 카피를 모두 전달할 수 있고, 결함 대립유전자를 수복을 초래하여 기능적 심장 단백질(예: 기능성 트로포닌 등)의 생성을 제공할 수 있다. 일부 실시양태에서, 대상 rAAV 비리온은 부위-특이적 엔도뉴클레아제를 암호화하는 이종 뉴클레오티드 서열 및 결함 대립유전자의 기능적 카피를 암호화하는 이종 뉴클레오티드 서열을 포함하고, 여기서 기능적 카피는 기능적 심장 단백질을 암호화한다. 기능적 심장 단백질은, 예를 들면, 트로포닌, 염화물 이온 채널 등을 포함한다.
사용에 적합한 부위-특이적 엔도뉴클레아제는, 예를 들면, 징크 핑거 뉴클레아제(ZFN); 메가뉴클레아제; 및 전사 활성화인자-유사 이펙터 뉴클레아제(TALEN)가 포함되고, 여기서 이러한 부위-특이적 엔도뉴클레아제는 비-천연적으로 발생하고, 특정 유전자를 표적화하도록 변형된다. 이러한 부위-특이적 뉴클레아제는 게놈 내의 특정 위치를 절단하도록 조작될 수 있고, 비-상동 말단 연결은 몇몇 뉴클레오티드를 삽입 또는 결실하면서 절단을 수복할 수 있다. 이어서, 이러한 부위 특이적 엔도뉴클레아제("INDEL"이라고도 함)는 단백질을 프레임 밖으로 내보내고, 유전자를 효과적으로 녹아웃시킨다[참조: 예를 들면, 미국 특허 공보 제2011/0301073호]. 적합한 부위-특이적 엔도뉴클레아제는 조작된 메가뉴클레아제 재조작된 호밍(homing) 엔도뉴클레아제를 포함한다. 적합한 엔도뉴클레아제는 I-Tevl 뉴클레아제를 포함한다. 적합한 메가뉴클레아제는 I-Scel[참조: 예를 들면, Bellaiche et al. (1999) Genetics 152: 1037]; 및 I-Crel[참조: 예를 들면, Heath et al.(1997) Nature Structural Biology 4:468]를 포함한다. 사용에 적합한 부위 특이적 엔도뉴클레아제에는 CRISPRi 시스템 및 Cas9 기반 SAM 시스템이 포함된다.
일부 실시양태에서, 유전자 산물은 RNA-유도 엔도뉴클레아제이다. 일부 실시양태에서, 유전자 산물은 RNA-유도 엔도뉴클레아제를 암호화하는 뉴클레오티드 서열을 포함하는 RNA를 포함한다. 일부 실시양태에서, 유전자 산물은 가이드 RNA, 예를 들면, 단일-가이드 RNA이다. 일부 실시양태에서, 유전자 산물은 1) 가이드 RNA; 및 2) RNA-유도 엔도뉴클레아제이다. 가이드 RNA는 a) RNA-유도 엔도뉴클레아제에 결합하는 단백질 결합 영역; 및 b) 표적 핵산에 결합하는 영역을 포함할 수 있다. RNA-유도 엔도뉴클레아제는 또한 본원에서 "게놈 편집 뉴클레아제"로 지칭된다.
적합한 게놈 편집 뉴클레아제의 예는 CRISPR/Cas 엔도뉴클레아제(예: 유형 II, 유형 V 또는 유형 VI CRISPR/Cas 엔도뉴클레아제 등의 클래스 2 CRISPR/Cas 엔도뉴클레아제)이다. 적합한 게놈 편집 뉴클레아제는 CRISPR/Cas 엔도뉴클레아제(예를 들면, 유형 II, 유형 V 또는 유형 VI CRISPR/Cas 엔도뉴클레아제 등의 클래스 2 CRISPR/Cas 엔도뉴클레아제)이다. 일부 실시양태에서, 유전자 산물은 클래스 2 CRISPR/Cas 엔도뉴클레아제를 포함한다. 일부 실시양태에서, 유전자 산물은 클래스 2 유형 II CRISPR/Cas 엔도뉴클레아제(예를 들면, Cas9 단백질)를 포함한다. 일부 실시양태에서, 유전자 산물은 클래스 2 유형 V CRISPR/Cas 엔도뉴클레아제(예를 들면, Cpfl 단백질, C2cl 단백질, 또는 C2c3 단백질)를 포함한다. 일부 실시양태에서, 유전자 산물은 클래스 2 유형 VI CRISPR/Cas 엔도뉴클레아제(예를 들면, C2c2 단백질; "Casl3a" 단백질로도 지칭됨)를 포함한다. 일부 실시양태에서, 유전자 산물은 CasX 단백질을 포함한다. 일부 실시양태에서, 유전자 산물은 CasY 단백질을 포함한다.
사용 방법
일부 실시양태에서, 본 개시는 rAAV 비리온에 표적 세포에서 형질도입 효율의 증가를 부여하는 AAV 캡시드 단백질을 동정하는 방법을 제공한다. 이 방법은, 이의 rAAV 게놈이 변이체 AAV 캡시드 단백질을 암호화하는 cap 폴리뉴클레오티드의 라이브러리를 포함하는 rAAV 비리온의 집단을 제공하는 단계; 임의로, 원하지 않는 rAAV 비리온을 비-표적 세포(non-target cell)에 부착시키기에 충분한 시간 동안 집단을 비-표적 세포와 접촉시키는 단계; rAAV 비리온에 의해 cap 폴리뉴클레오티드의 표적 세포 내로의 형질도입을 허용하기에 충분한 시간 동안 집단을 표적 세포와 접촉시키는 단계; 및 표적 세포로부터 cap 폴리뉴클레오티드를 서열분석함으로써 표적 세포에서 형질도입 효율의 증가를 부여하는 AAV 캡시드 단백질을 동정하는 단계를 포함한다. 일부 실시양태에서, 이 방법은, rAAV 비리온의 비-표적 세포에 대한 부착을 허용하기에 충분한 시간 동안 집단을 비-표적 세포와 접촉시킴으로써 rAAV 비리온의 집단을 고갈시키는 단계를 추가로 포함한다. 이러한 식별 방법의 비제한적 예는 실시예에 제공된다.
본 개시는 rAAV 비리온을 사용하여 시험관내에서 심근세포 및/또는 심근세포-유사 세포를 생성하는 방법을 제공한다. 선택된 개시 세포는 rAAV로 형질도입되고, 임의로, 계통 및/또는 분화 경계를 가로질러 개시 세포를 전환하여 심장 전구 세포 및/또는 심근세포를 형성하기에 충분한 시간 및 조건하에서 소분자 재프로그래밍 인자(형질도입 전, 동안 또는 후에)에 노출된다. 일부 실시양태에서, 개시 세포는 섬유아세포이다. 일부 실시양태에서, 개시 세포는 분화된 표현형을 나타내는 하나 이상의 마커를 발현한다. 개시 세포가 심장 전구 세포와 심근세포로 전환되는 시간은 변동할 수 있다. 예를 들면, 개시 세포는 심장 또는 심근 세포 마커가 발현될 때까지, 목적의 하나 이상의 폴리뉴클레오티드 또는 단백질로 처리한 후에 인큐베이팅될 수 있다. 이러한 심장 또는 심근세포 마커는 하기 마커: α-GATA4, TNNT2, MYH6, RYR2, NKX2-5, MEF2C, ANP, 액티닌, MLC2v, MY20, cMHC, ISL1, cTNT, cTNI 및 MLC2a 또는 이의 임의의 조합 중 임의의 것을 포함할 수 있다. 일부 실시양태에서, 유도된 심근 세포는 하나 이상의 신경 세포 마커에 대해 음성이다. 이러한 신경 세포 마커는 하기 마커: DCX, TUBB3, MAP2 및 ENO2 중 임의의 것을 포함할 수 있다.
배양은 심장 전구세포 마커가 개시 세포에 의해 발현될 때까지 진행될 수 있다. 이러한 심장 전구세포 마커에는 GATA4, TNNT2, MYH6, RYR2 또는 이들의 조합이 포함된다. GATA4, TNNT2, MYH6, RYR2 또는 이들의 조합 등의 심장 전구 마커는, 본원에 기재된 조성물 중의 세포의 인큐베이션을 개시한 후, 약 8일, 또는 약 9일, 또는 약 10일, 또는 약 11일, 또는 약 12일, 또는 약 14일, 또는 약 15일, 또는 약 16일, 또는 약 17일, 또는 약 18일, 또는 약 19일, 또는 약 20일까지 발현될 수 있다. 세포의 추가 인큐베이션은, NKX2-5, MEF2C 또는 이들의 조합 등의 후기 심장 전구세포 마커의 발현이 발생할 때까지 실행할 수 있다.
재프로그래밍 효율은 심근세포 마커의 함수로 측정될 수 있다. 이러한 다능성 마커에는 심근세포 마커 단백질 및 mRNA의 발현, 심근세포 형태 및 전기생리학적 표현형이 포함되지만, 이들로 한정되지 않는다. 심근세포 마커의 비제한적 예에는 α-사르코글리칸, 심방 나트륨 이뇨 펩티드(ANP), 골 형태형성 단백질 4(BMP4), 코넥신 37, 코넥신 40, 크립토, 데스민, GATA4, GATA6, MEF2C, MYH6, 미오신 중쇄, NKX2.5, TBX5 및 트로포닌 T가 포함된다.
심근세포에 특이적인 다양한 마커의 발현은 종래의 생화학적 또는 면역화학적 방법(예를 들면, 효소 결합 면역흡착 검정, 면역조직화학적 검정 등)에 의해 검출될 수 있다. 또는, 심근세포-특이적 마커를 암호화하는 핵산의 발현을 평가할 수 있다. 세포 내의 심근세포-특이적 마커를 암호화하는 핵산의 발현은 역전사효소 폴리머라제 연쇄 반응(RT-PCR) 또는 하이브리드화 분석, 임의의 마커 단백질을 코딩하는 mRNA를 증폭, 검출 및 분석하기 위해 과거에 일반적으로 사용되었던 분자생물학적 방법에 의해 확인할 수 있다. 심근세포에 특이적인 마커를 코딩하는 핵산 서열은 공지되어 있고, GenBank 등의 공개 데이터베이스를 통해 이용 가능하다. 따라서, 프라이머 또는 프로브로 사용하기 위해 필요한 마커 특이적 서열은 용이하게 결정된다.
심근세포는 심장 특유의 전기생리학적 특성을 나타낸다. 전기적 특성의 하나는 활동 전위이고, 이는 각 심장 세포의 내부와 외부의 전위 차이가 일관된 궤적을 따라 오르락 내리락하는 단기 이벤트이다. 심근세포의 또 다른 전기생리학적 특징은, 심근세포의 수축 및 이완 조절에 사용되는 Ca2+ 과도현상으로 명명된 세포질-비함유 Ca2+ 농도의 주기적 변화이다. 이러한 특성을 검출 및 평가하여, 세포 집단이 심근세포로 재프로그래밍되었는지 여부를 평가할 수 있다.
본 개시는 유전자 산물을 심장 세포, 예를 들면, 심장 섬유아세포에 전달하는 방법을 제공한다. 이 방법은 일반적으로 심장 세포(예: 심장 섬유아세포)를 rAAV 비리온으로 감염시키는 것을 포함하고, 여기서 rAAV 비리온에 존재하는 이종 핵산에 의해 암호화된 유전자 산물(들)은 심장 세포(예: 심장 섬유아세포)에서 생산된다. 심장 세포(예: 심장 섬유아세포)로의 유전자 산물(들)의 전달은 심장 질환 또는 장애의 치료를 제공할 수 있다. 심장 세포(예를 들면, 심장 섬유아세포)로의 유전자 산물(들)의 전달은 심장 섬유아세포로부터 유도된 심근세포-유사(iCM) 세포의 생성을 제공할 수 있다. 심장 세포(예를 들면, 심장 섬유아세포)로의 유전자 산물(들)의 전달은 심장 세포(예를 들면, 심장 섬유아세포)의 게놈의 편집을 제공할 수 있다.
일부 실시양태에서, 심장 세포(예를 들면, 심장 섬유아세포)로의 감염 또는 형질도입은 시험관내에서 수행된다. 일부 실시양태에서, 심장 세포(예를 들면, 심장 섬유아세포)로의 감염 또는 형질도입은 시험관내에서 수행되고; 감염/형질도입된 심장 세포(예: 심장 섬유아세포)는 이를 필요로 하는 개체에, 예를 들면, 이를 필요로 하는 개체의 심장 조직 내로 직접 도입(예: 수혈 또는 이식)된다. 시험관내 형질도입의 경우, 세포에 전달될 유효량의 rAAV 비리온은 rAAV 비리온의 약 105 내지 약 1013이다. 다른 유효 투여량은 용량 반응 곡선을 확립하는 일상적 시험을 통해 당업자에 의해 용이하게 확립될 수 있다.
일부 실시양태에서, 심장 세포(예를 들면, 심장 섬유아세포)로의 감염은 생체내에서 수행된다. 예를 들면, 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 이를 필요로 하는 개체의 심장 조직 내로 직접 투여된다. "유효량"은 실험 및/또는 임상 시험을 통해 결정할 수 있는 비교적 넓은 범위에 속한다. 예를 들면, 생체내 주사, 즉 심장 조직으로의 직접 주사의 경우, 치료학적 유효 용량은 본 개시의 rAAV 비리온의 약 106 내지 약 1015, 예를 들면, 약 105 내지 1012의 rAAV 비리온일 것이다. 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 심외막을 통한 심근내 주사를 통해 투여된다. 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 관상 동맥을 통한 혈관 전달을 통해 투여된다. 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 상대 대정맥을 통한 전신 전달을 통해 투여된다. 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 말초 정맥을 통한 전신 전달을 통해 투여된다.
예를 들면, 약 104 내지 약 105, 약 105 내지 약 106, 약 106 내지 약 107, 약 106 내지 약 107, 약 107 내지 약 108, 약 108 내지 약 109, 약 109 내지 약 1010, 약 1010 내지 약 1011, 약 1011, 약 1011 내지 약 1012, 약 1012 내지 약 1013, 약 1013 내지 약 1014, 약 1014 내지 약 1015의 게놈 카피, 또는 1015 이상의 게놈 카피의 본 개시의 rAAV 비리온은, 예를 들면, 개체에게 투여되고, 예를 들면, 개체의 심장 조직에 직접 투여되거나, 다른 경로를 통해 투여된다. 개체에게 투여된 rAAV 비리온의 수는 개체의 체중 킬로그램(kg)당 바이러스 게놈(vg)으로 표현될 수 있다. 일부 실시양태에서, 본 개시의 rAAV 비리온의 유효량은 약 102 vg/kg 내지 104 vg/kg, 약 104 vg/kg 내지 약 106 vg/kg, 약 106 vg/kg 내지 약 108 vg/kg, 약 108 vg/kg 내지 약 1010 vg/kg, 약 1010 vg/kg 내지 약 1012 vg/kg, 약 1012 vg/kg 내지 약 1014 vg/kg, 약 1014 vg/kg 내지 약 1016 vg/kg, 약 1016 vg/kg 내지 약 1018 vg/kg, 또는 1018 vg/kg 초과이다.
일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 심외막을 통한 심근내 주사를 통해 투여된다. 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 관상 동맥을 통한 혈관 전달을 통해 투여된다. 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 상대 대정맥을 통한 전신 전달을 통해 투여된다. 일부 실시양태에서, 본 개시의 유효량의 rAAV 비리온은 말초 정맥을 통한 전신 전달을 통해 투여된다.
일부 실시양태에서, 원하는 수준의 유전자 발현을 달성하기 위해, 1회 이상의 투여(예를 들면, 2회, 3회, 4회 또는 그 이상의 투여)가 사용될 수 있다. 일부 실시양태에서, 1회 초과의 투여는 다양한 간격으로, 예를 들면, 매일, 매주, 매월 2회, 매월, 3개월마다, 6개월마다, 매년 등으로 투여된다. 일부 실시양태에서, 복수회 투여는 1개월 내지 2개월, 2개월 내지 4개월, 4개월 내지 8개월, 8개월 내지 12개월, 1년 내지 2년, 2년 내지 5년, 또는 5년 이상의 기간에 걸쳐 투여된다.
본 개시는 유도 심근세포-유사 세포(iCM)를 생성하기 위해 심장 섬유아세포를 재프로그래밍하는 방법을 제공한다. 이 방법은, 일반적으로, 심장 섬유아세포를 본 개시의 rAAV 비리온으로 감염시키는 것을 포함하고, 여기서 rAAV 비리온은 하나 이상의 재프로그래밍 인자를 암호화하는 뉴클레오티드 서열을 포함하는 이종 핵산을 포함한다.
심근세포에 특이적인 다양한 마커의 발현은 종래의 생화학적 또는 면역화학적 방법(예를 들면, 효소-결합 면역흡착 검정, 면역조직화학적 검정 등)에 의해 검출된다. 또는, 심근세포-특이적 마커를 암호화하는 핵산의 발현을 평가할 수 있다. 세포 내에서 심근세포-특이적 마커를 암호화하는 핵산의 발현은 역전사효소 폴리머라제 연쇄 반응(RT-PCR) 또는 하이브리드화 분석, 임의의 마커 단백질을 코딩하는 mRNA를 증폭, 검출 및 분석하기 위해 과거에 일반적으로 사용되었던 분자생물학적 방법을 통해 확인할 수 있다. 심근세포에 특이적인 마커를 코딩하는 핵산 서열은 알려져 있고, GenBank 등의 공개 데이터베이스를 통해 이용가능하고, 따라서 프라이머 또는 프로브로서 사용하기 위해 필요한 마커 특이적 서열을 용이하게 결정할 수 있다.
유도된 심근세포는 또한 자발적 수축을 나타낼 수 있다. 유도된 심근세포가 자발적 수축을 나타내는지 여부는 표준 전기생리학적 방법(예: 패치 클램프)을 사용하여 결정할 수 있다.
일부 실시양태에서, 유도된 심근세포는 자발적인 Ca2+ 진동을 나타낼 수 있다. Ca2+ 진동은 표준 방법, 예를 들면, 다양한 칼슘 감수성 염료, 세포내 Ca2+ 이온 검출 염료를 사용하여 검출할 수 있고, 하기를 포함하지만 이들로 한정되지 않는다: fura-2, bis-fura 2, indo-1, Quin-2, Quin-2 AM, 벤조티아자-1, 벤조티아자-2, indo-5F, Fura-FF, BTC, Mag-Fura-2, Mag-Fura-5, Mag-Indo-1, fluo-3, rhod- 2, rhod-3, fura-4F, fura-5F, fura-6F, Fluo-4, Fluo-5F, Fluo-5N, 오레곤 그린(Oregon Green) 488 BAPTA, 칼슘 그린, 칼세인(Calcein), Fura-C18, 칼슘 그린-C18, 칼슘 오렌지, 칼슘 크림슨, 칼슘 그린-5N, 마그네슘 그린, 오레곤 그린 488 BAPTA-1, 오레곤 그린 488 BAPTA-2, X-rhod-1, Fura 레드, Rhod-5F, Rhod-5N, X-Rhod-5N, Mag-Rhod-2, Mag-X-Rhod-1, Fluo-5N, Fluo-5F, Fluo-4FF, Mag-Fluo-4, Aequorin, 덱스트란 접합체 또는 이들 염료의 기타 유도체 등[참조: 예를 들면, Molecular Probes에 대한 카탈로그 또는 인터넷 사이트, Eugene, 또한, 하기 참조, Nuccitelli, ed., Methods in Cell Biology, Volume 40: A Practical Guide to the Study of Calcium in Living Cells, Academic Press (1994); Lambert, ed., Calcium Signaling Protocols (Methods in Molecular Biology Volume 114), Humana Press (1999); W. T. Mason, ed., Fluorescent and Luminescent Probes for Biological Activity. A Practical Guide to Technology for Quantitative Real-Time Analysis, Second Ed, Academic Press (1999); Calcium Signaling Protocols (Methods in Molecular Biology), 2005, D.G. Lamber, ed., Humana Press].
일부 실시양태에서, iCM은 시험관내에서 생성되고; iCM은 개체에게 도입되고, 예를 들면, iCM은 이를 필요로 하는 개체의 심장 조직에 이식된다. 본 개시의 방법은 시험관내에서 심장 섬유아세포의 집단을 감염시켜 iCM의 집단을 생성하는 것을 포함할 수 있고; iCM의 집단은 이를 필요로 하는 개체의 심장 조직에 이식된다.
일부 실시양태에서, iCM은 생체내에서 생성된다. 예를 들면, 일부 실시양태에서, 하나 이상의 재프로그래밍 인자를 암호화하는 뉴클레오티드 서열을 포함하는 이종성 핵산을 포함하는 본 개시의 rAAV 비리온이 개체에게 투여된다. 일부 실시양태에서, rAAV 비리온은 이를 필요로 하는 개체의 심장 조직 내로 직접 투여된다. 일부 실시양태에서, 하나 이상의 재프로그래밍 인자를 암호화하는 뉴클레오티드 서열을 포함하는 이종 핵산을 포함하는, 약 106 내지 약 105, 약 105 내지 약 109, 약 109 내지 약 1010, 약 1010 내지 약 1011, 약 1011 내지 약 1012, 약 1012 내지 약 1013, 약 1013 내지 약 1014개, 약 1014개 내지 약 1015개 게놈 카피, 또는 1015개 초과 게놈 카피의 본 개시의 rAAV 게놈이 개체에게 투여되고, 예를 들면, 개체의 심장 조직에 직접 투여되거나, 다른 투여 경로를 통해 투여된다. 개체에게 투여된 rAAV 비리온의 수는 개체의 체중 킬로그램(kg)당 바이러스 게놈(vg)으로 표현될 수 있다. 일부 실시양태에서, 본 개시의 rAAV 비리온의 유효량은 약 102 vg/kg 내지 104 vg/kg, 약 104 vg/kg 내지 약 106 vg/kg, 약 106 vg/kg 내지 약 108 vg/kg, 약 108 vg/kg 내지 약 1010 vg/kg, 약 1010 vg/kg 내지 약 1012 vg/kg, 약 1012 vg/kg 내지 약 1014 vg/kg, 약 1014 vg/kg 내지 약 1014 vg/kg, 약 1014 vg/kg 내지 약 1016 vg/kg, 또는 1016 vg/kg 초과이다. 일부 실시양태에서, 본 개시의 유효량의 rAAV 비리온은 심외막을 통한 심근내 주사를 통해 투여된다. 일부 실시양태에서, 본 개시의 유효량의 rAAV 비리온은 관상 동맥을 통한 혈관 전달을 통해 투여된다. 일부 실시양태에서, 본 개시의 유효량의 rAAV 비리온은 상대 대정맥을 통한 전신 전달을 통해 투여된다. 일부 실시양태에서, 본 개시의 유효량의 rAAV 비리온은 말초 정맥을 통한 전신 전달을 통해 투여된다.
본 개시는 심장 세포의 게놈을 변형("편집")하는 방법을 제공한다. 본 개시는 심장 섬유아세포의 게놈을 변형("편집")하는 방법을 제공한다. 본 개시는 심근세포의 게놈을 변형("편집")하는 방법을 제공한다. 방법은 일반적으로 심장 세포(예를 들면, 심장 섬유아세포 또는 심근세포)를 본 개시내용의 rAAV 비리온으로 감염시키는 것을 포함하고, 여기서 rAAV 비리온은 게놈-편집 엔도뉴클레아제를 암호화하는 뉴클레오티드 서열을 포함하는 이종 핵산을 포함한다. 일부 실시양태에서, 방법은 심장 섬유아세포 또는 심근세포를 본 개시내용의 rAAV 비리온으로 감염시키는 것을 포함하고, 여기서 rAAV 비리온은 RNA-유도 게놈-편집 엔도뉴클레아제를 암호화하는 뉴클레오티드 서열을 포함하는 이종 핵산을 포함한다. 일부 실시양태에서, 방법은 심장 섬유아세포 또는 심근세포를 본 개시내용의 rAAV 비리온으로 감염시키는 것을 포함하고, 여기서 rAAV 비리온은 i) RNA-유도 게놈-편집 엔도뉴클레아제; 및 ii) 하나 이상의 가이드 RNA를 암호화하는 뉴클레오티드 서열을 포함한다. 일부 실시양태에서, 이 방법은 심장 섬유아세포 또는 심근세포를 본 개시의 rAAV 비리온으로 감염시키는 것을 포함하고, 여기서 rAAV 비리온은 i) RNA-유도 게놈-편집 엔도뉴클레아제; ii) 가이드 RNA; 및 iii) 공여자 주형 DNA를 암호화하는 뉴클레오티드 서열을 포함한다. 적합한 RNA-유도된 게놈-편집 엔도뉴클레아제는 상기 설명되어 있다.
일부 실시양태에서, 심장 세포(예를 들면, 심장 섬유아세포; 심근세포)를 감염시키는 것은 시험관내에서 수행된다. 일부 실시양태에서, 심장 세포(예를 들면, 심장 섬유아세포; 심근세포)를 감염시키는 것은 시험관내에서 수행되고; 감염된 심장 세포(예를 들면, 심장 섬유아세포)는 이를 필요로 하는 개체 내로, 예를 들면, 이를 필요로 하는 개체의 심장 조직 내로 직접 도입(예를 들면, 이식)된다. 시험관내 형질도입의 경우, 세포에 전달될 유효량의 rAAV 비리온은 약 105 내지 약 1013 정도의 rAAV 비리온일 것이다. 다른 유효 투여량은 용량 반응 곡선을 확립하는 일상적인 시험을 통해 당업자에 의해 용이하게 확립될 수 있다.
일부 실시양태에서, 심장 세포(예를 들면, 심장 섬유아세포; 심근세포)를 감염시키는 것은 생체내에서 수행된다. 예를 들면, 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은, 이를 필요로 하는 개체의 심장 조직 내로 직접 투여된다. "유효량"은 실험 및/또는 임상 시험을 통해 결정할 수 있는 비교적 넓은 범위에 속한다. 예를 들면, 생체내 주사, 즉 심장 조직으로의 직접 주사의 경우, 치료학적 유효 용량은 본 개시의 rAAV 비리온의 약 106 내지 약 1015, 예를 들면, 약 1011 내지 1012 rAAV 비리온일 것이다. 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 심외막을 통한 심근내 주사를 통해 투여된다. 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 관상 동맥을 통한 혈관 전달을 통해 투여된다. 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 상대 대정맥을 통한 전신 전달을 통해 투여된다. 일부 실시양태에서, 본 개시의 rAAV 비리온의 유효량은 말초 정맥을 통한 전신 전달을 통해 투여된다.
예를 들면, 약 106 내지 약 107, 약 107 내지 약 108, 약 108 내지 약 109, 약 109 내지 약 1010, 약 1010 내지 약 1011, 약 1011 내지 약 1012, 약 1012 내지 약 1013, 약 1013 내지 약 1014, 약 1014 내지 약 1015 게놈 카피, 또는 1015 초과의 게놈 카피의 본 개시의 rAAV 비리온이 개체에게 투여되고, 예를 들면, 개체의 심장 조직 내로 직접 투여된다. 개체에게 투여된 rAAV 비리온의 수는 개체의 체중 킬로그램(kg)당 바이러스 게놈(vg)으로 표현될 수 있다. 일부 실시양태에서, 본 개시의 rAAV 비리온의 유효량은 약 102 vg/kg 내지 104 vg/kg, 약 104 vg/kg 내지 약 106 vg/kg, 약 106 vg/kg 내지 약 108 vg/kg, 약 108 vg/kg 내지 약 1010 vg/kg, 약 1010 vg/kg 내지 약 1012 vg/kg, 약 1012 vg/kg 내지 약 1014 vg/kg, 약 1014 vg/kg 내지 약 1016 vg/kg, 약 1016 vg/kg 내지 약 1018 vg/kg, 또는 1018 vg/kg 초과이다. 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 심외막을 통한 심근내 주사를 통해 투여된다. 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 관상 동맥을 통한 혈관 전달을 통해 투여된다. 일부 실시양태에서, 유효량의 본 개시의 rAAV 비리온은 상대 대정맥을 통한 전신 전달을 통해 투여된다. 일부 실시양태에서, 본 개시의 rAAV 비리온의 유효량은 말초 정맥을 통한 전신 전달을 통해 투여된다.
일부 실시양태에서, 게놈 편집은 상동성 지향 수복(HDR)을 포함한다. 일부 실시양태에서, HDR은 심장 섬유아세포 또는 심근세포에서 내인성 표적 핵산의 결함을 교정하고, 여기서 결함은 심장 섬유아세포 또는 심근세포의 구조 및/또는 기능, 또는 또는 심장 섬유아세포 또는 심근세포의 성분의 결함과 연관되거나, 또는 이를 유도한다.
일부 실시양태에서, 게놈 편집은 비-상동 말단 연결(NHEJ)을 포함한다. 일부 실시양태에서, NHEJ는 심장 섬유아세포 또는 심근세포에서 내인성 표적 핵산의 결함을 결실시키고, 여기서 결함은 심장 섬유아세포 또는 심근세포의 구조 및/또는 기능, 또는 또는 심장 섬유아세포 또는 심근세포의 성분의 결함과 연관되거나, 이를 유도한다.
심장 세포의 게놈을 편집하기 위한 본 개시의 방법은 심장 질환 또는 장애를 야기하는 임의의 다양한 유전적 결함을 교정하는데 사용될 수 있다. 목적 돌연변이에는 하기 유전자 중 하나 이상의 돌연변이가 포함된다: 심장 트로포닌 T(TNNT2); 미오신 중쇄(MYH7); 트로포미오신 1(TPM1); 미오신 결합 단백질 C(MYBPC3); 5'-AMP 활성화 단백질 키나제 서브유닛 감마-2(PRKAG2); 트로포닌 I형 3(TNNI3); 티틴(TTN); 미오신, 경쇄 2(MYL2); 액틴, 알파 심장 근육 1(ACTC1); 칼륨 전압-게이트 채널, KQT-유사 서브패밀리, 구성원 1(KCNQ1); 플라코필린 2(PKP2); 근세포 인핸서 인자 2c(MEF2C); 및 심장 LIM 단백질(CSRP3). 특정 목적 돌연변이에는 MYH7 R663H 돌연변이; TNNT2 R173W; PKP2 2013delC 돌연변이; PKP2 Q617X 돌연변이; 및 KCNQ1 G269S 미스센스 돌연변이가 포함되지만, 이들로 한정되지 않는다. 목적 돌연변이에는 MYH6, ACTN2, SERCA2, GATA4, TBX5, MYOCD, NKX2-5, NOTCH1, MEF2C, HAND2 및 HAND1 유전자 중 하나 이상의 돌연변이가 포함된다. 일부 실시양태에서, 목적 돌연변이는 하기 유전자에서의 돌연변이를 포함한다: MEF2C, TBX5, 및 MYOCD. 본 개시의 방법으로 치료될 수 있는 심장 질환 및 장애는 관상 심장 질환(coronary heart disease), 심근병증(cardiomyopathy), 심내막염(endocarditis), 선천성 심혈관 결함(congenital cardiovascular defects) 및 울혈성 심부전(congestive heart failure)을 포함한다. 본 개시의 방법으로 치료될 수 있는 심장 질환 및 장애는 비대성 심근병증(hypertrophic cardiomyopathy); 판막 심장병(a valvular heart disease); 심근 경색증(myocardial infarction); 울혈성 심부전증(congestive heart failure); 긴 QT 증후군(long QT syndrome); 심방 부정맥(atrial arrhythmia); 심실성 부정맥(ventricular arrhythmia); 이완기 심부전(diastolic heart failure); 수축기 심부전(systolic heart failure); 심장 판막 질환(cardiac valve disease); 심장 판막 석회화(cardiac valve calcification); 좌심실 비압축(left ventricular non-compaction); 심실 중격 결손(ventricular septal defect); 및 허혈(ischemia)을 포함한다.
치료 방법
본 개시는, rAAV 비리온을 포함하는 약제학적 조성물의 치료학적 유효량을 대상체에게 투여하는 것을 포함하는, 이를 필요로 하는 대상체에서 심장 병리를 치료하는 방법을 제공하고, 여기서 rAAV 비리온은 심장 조직을 형질도입한다.
본 개시의 조성물 및 방법을 사용한 치료를 필요로 하는 대상체는 선천성 심장 결함을 갖는 개체, 퇴행성 근육 질환을 앓고 있는 개체, 허혈성 심장 조직을 초래하는 상태를 앓고 있는 개체(예를 들면, 관상 동맥 질환을 갖는 개체)를 포함하지만, 이들로 한정되지 않는다. 일부 예에서, 이 방법은 퇴행성 근육 질환 또는 상태(예를 들면, 가족성 심근병증, 확장성 심근병증, 비대성 심근병증, 제한성 심근병증, 또는 허혈성 심근병증을 수반하는 관상 동맥 질환)를 치료하기 위해 유용한다. 일부 예에서, 대상 방법은 심장 또는 심혈관 질환 또는 장애, 예를 들면, 심혈관 질환(cardiovascular disease), 동맥류(aneurysm), 협심증(angina), 부정맥(arrhythmia), 죽상동맥경화증(atherosclerosis), 뇌혈관 사고(cerebrovascular accident)(뇌졸중(stroke)), 뇌혈관 질환(cerebrovascular disease), 선천성 심장 질환(congenital heart disease), 울혈성 심부전(congestive heart failure), 심근염(myocarditis), 판막 질환 관상동맥(valve disease coronary), 확장된 동맥 질환(artery disease dilated), 확장기 기능장애(diastolic dysfunction), 심내막염(endocarditis), 고혈압(high blood pressure)(고혈압(hypertension)), 심근병증(cardiomyopathy), 비후성 심근병증(hypertrophic cardiomyopathy), 제한성 심근병증(restrictive cardiomyopathy), 결과적으로 허혈성 심근병증을 수반한 관상동맥 질환(coronary artery disease), 승모판 탈출증(mitral valve prolapse), 심근경색(myocardial infarction)(심장마비(heart attack)) , 또는 정맥 혈전 색전증(venous thromboembolism)을 갖는 개체를 치료하기 위해 유용하다.
본 개시의 조성물, 세포 및 방법을 사용하여 치료하기에 적합한 대상체는, 허혈성 심장 조직을 초래하는 상태(예를 들면, 관상 동맥 질환이 있는 개체) 등을 포함하지만 이들로 한정되지 않는 심장 상태를 갖는 개체(예를 들면, 포유동물 대상체, 예컨대, 인간, 비인간 영장류, 가축 포유동물, 실험적 비인간 포유동물 대상체, 예컨대, 마우스, 래트 등)을 포함한다.
일부 예에서, 치료에 적합한 개체는, 심장 또는 심혈관 질환 또는 상태, 예를 들면, 심혈관 질환, 동맥류, 협심증, 부정맥, 죽상동맥경화증, 뇌혈관 사고(뇌졸중), 뇌혈관 질환, 선천성 심장 질환, 울혈성 심부전, 심근염, 판막 질환 관상동맥, 확장된 동맥 질환, 확장기 기능 장애, 심내막염, 고혈압(고혈압), 심근병증, 비후성 심근병증, 제한성 심근병증, 허혈성 심근병증을 수반한 관상동맥 질환, 승모판 탈출증, 심근경색증(심장마비) 또는 정맥 혈전 색전증을 앓고 있다. 일부 예에서, 주제의 방법으로 치료하기에 적합한 개체는 퇴행성 근육 질환, 예를 들면, 가족성 심근병증, 확장성 심근병증, 비후성 심근병증, 제한성 심근병증, 또는 결과적으로 허혈성 심근병증을 수반하는 관상 동맥 질환을 갖는 개체를 포함한다.
예를 들면, 심장 병리는 울혈성 심부전, 심근경색증, 심장 허혈, 심근염 및 부정맥으로 이루어진 그룹으로부터 선택될 수 있다. 일부 실시양태에서, 대상체는 당뇨병이다. 일부 실시양태에서, 대상체는 비-당뇨병이다. 일부 실시양태에서, 대상체는 당뇨병성 심근병증을 앓고 있다.
치료를 위해, 본 개시의 rAAV 비리온 및/또는 이의 약제학적 조성물은 국소적으로 또는 전신적으로 투여될 수 있다. rAAV 비리온은 주사, 카테터, 이식가능한 장치 등에 의해 도입될 수 있다. rAAV 비리온은 세포에 악영향을 미치지 않는 임의의 생리학적으로 허용되는 부형제 또는 담체로 투여될 수 있다. 예를 들면, 본 개시의 rAAV 비리온 및/또는 이의 약제학적 조성물은 정맥내로 또는 심장내 경로(예를 들면, 심외막 또는 심근내로) 투여될 수 있다. 본 개시의 rAAV 비리온 및/또는 이의 약제학적 조성물을 대상체, 특히 인간 대상체에게 투여하는 방법은 약제학적 조성물(예를 들면, rAAV 비리온을 포함하는 조성물)의 주사 또는 주입을 포함한다. 주사는 직접 근육 주사를 포함할 수 있고, 주입은 혈관내 주입을 포함할 수 있다. rAAV 비리온 또는 약제학적 조성물은 대상체로의 주사에 의한 도입을 용이하게 하는 전달 장치에 삽입될 수 있다. 이러한 전달 장치는 수용자 대상체의 신체에 세포 및 유체를 주입하기 위한 튜브, 예를 들면, 카테터를 포함한다. 튜브는 추가로, 바늘, 예를 들면, 주사기를 포함할 수 있고, 이를 통해 본 발명의 세포를 대상체의 목적하는 위치에 도입할 수 있다.
일부 실시양태에서, rAAV 비리온은 피하, 정맥내, 근육내, 복강내, 또는 심장내 주사에 의해 또는 심장내 카테터삽입(catheterization)에 의해 투여된다. 일부 실시양태에서, rAAV 비리온은 직접 심근내 주사 또는 경혈관 투여에 의해 투여된다. 일부 실시양태에서, rAAV 비리온은 직접 심근내 주사, 순행성 관상동맥내 주사, 역행성 주사, 경심내막 주사(transendomyocardial injection), 또는 재순환 전달을 수반하는 분자 심장 수술(MCARD)에 의해 투여된다.
rAAV 비리온은 이러한 전달 장치, 예를 들면, 주사기에 다양한 형태로 삽입될 수 있다. rAAV 비리온은 약제학적 조성물의 형태로 공급될 수 있다. 이러한 조성물은 인간 투여를 위한 충분히 멸균된 조건하에 제조된 등장성 부형제를 포함할 수 있다. 의약 제제의 일반 원칙에 대해서는 독자는 문헌[참조: Cell Therapy: Stem Cell Transplantation, Gene Therapy, and Cellular Immunotherapy, by G. Morstyn & W. Sheridan eds, Cambridge University Press, 1996; and Hematopoietic Stem Cell Therapy, E. D. Ball, J. Lister & P. Law, Churchill Livingstone, 2000]을 참조한다. 조성물의 부형제 및 수반되는 성분의 선택은 사용된 경로 및/또는 장치에 의해 투여를 최적화하도록 적합시킬 수 있다.
재조합 AAV는 국소적으로 또는 전신적으로 투여될 수 있다. 재조합 AAV는 본 개시의 적절한 캡시드 단백질을 선택함으로써 특정 세포 유형을 표적화하도록 조작될 수 있다. 다양한 치료적 투여 섭생 및 AAV 비리온 조성물의 투여량의 적합성을 결정하기 위해, rAAV 비리온을 먼저 적합한 동물 모델에서 시험할 수 있다. 어느 수준에서, 재조합 AAV는 생체내에서 표적 세포를 감염시키는 능력에 대해 평가된다. 재조합 AAV를 평가하여, 표적 조직으로 이동하는지, 숙주에서 면역 반응을 유도하는지를 확인하거나, 또는 투여될 rAAV 비리온의 적절한 수 또는 투여량을 결정할 수 있다. 치료할 질병에 따라, 재조합 AAV가 면역 반응을 생성하는 것이 바람직하거나 바람직하지 않을 수 있다. 일반적으로, 비리온의 반복 투여가 필요한 경우, 비리온이 면역원성이 아닌 경우에 유리할 것이다. 시험 목적으로, rAAV 비리온 조성물을 면역결핍 동물(예를 들면, 누드 마우스, 또는 화학적으로 또는 방사선 조사에 의해 면역결핍으로 된 동물)에 투여할 수 있다. 표적 조직 또는 세포는 감염 기간 후에 회수될 수 있고, 조직 또는 세포가 감염되었는지 및 원하는 표현형(예: 유도된 심근세포)이 표적 조직 또는 세포에서 유도되었는지를 결정하기 위해 평가될 수 있다.
재조합 AAV 비리온은 심장으로의 직접 주사 또는 심장 카테터삽입을 포함하지만 이들로 한정되지 않는 다양한 경로에 의해 투여될 수 있다. 또는, rAAV 비리온은 정맥내 주입 등의 전신적으로 투여될 수 있다. 직접 주사를 사용하는 경우, 심장 절개 수술 또는 최소 침습 수술 중 어느 하나에 의해 실행할 수 있다. 일부 실시양태에서, 재조합 바이러스는 주사 또는 주입에 의해 심막강으로 전달된다. 주사 또는 주입된 재조합 바이러스는 다양한 방법으로 추적할 수 있다. 예를 들면, 검출가능한 표지(예: 녹색 형광 단백질 또는 베타-갈락토시다제)로 표지되거나, 또는 이를 발현하는 재조합 AAV를 용이하게 검출할 수 있다. 재조합 AAV는, 표적 세포가 표면-발현 단백질 또는 형광 단백질 등의 마커 단백질을 발현하도록 조작될 수 있다. 또는, 재조합 AAV에 의한 표적 세포의 감염은, 시험에 사용된 동물에 의해 발현되지 않는 세포 마커의 발현에 의해 검출될 수 있다(예를 들면, 실험 동물에 세포를 주입할 때의 인간 특이적 항원). 표적 세포의 존재 및 표현형은 형광현미경(예: 녹색 형광 단백질 또는 베타-갈락토시다제), 면역조직화학(예: 인간 항원에 대한 항체 사용), ELISA(인간 항원에 대한 항체 사용), 또는 증폭이 심장 표현형을 나타내는 RNA에 특이적이게 하는 프라이머 및 하이브리드화 조건을 사용한 RT-PCR 분석에 의해 평가할 수 있다.
약제학적 조성물
본 개시는 본 개시의 rAAV 비리온을 포함하는 약제학적 조성물을 제공한다. 약제학적 조성물은 약제학적으로 허용되는 담체, 희석제, 부형제 및 완충제 중 하나 이상을 포함할 수 있다. 일부 실시양태에서, 약제학적으로 허용되는 담체, 희석제, 부형제 또는 완충제는 인간에서 사용하기에 적합하다. 이러한 부형제, 담체, 희석제 및 완충제는 과도한 독성 없이 투여될 수 있는 임의의 약제를 포함한다. 약제학적으로 허용되는 부형제는 물, 식염수, 글리세롤 및 에탄올 등의 액체를 포함하지만 이들로 한정되지 않다. 약제학적으로 허용되는 염, 예를 들면, 염산염, 브롬화수소산염, 인산염, 황산염 등의 무기산염; 및 아세테이트, 프로피오네이트, 말로네이트, 벤조에이트 등의 유기산의 염을 그 중에 포함할 수 있다. 추가로, pH 완충 물질 등의 보조 물질이 이러한 비히클에 존재할 수 있다. 다종 다양한 약제학적으로 허용되는 부형제가 당해 기술분야에 공지되어 있고, 본원에서 상세하게 논의될 필요는 없다. 약제학적으로 허용되는 부형제는, 예를 들면, 문헌[참조: A. Gennaro (2000) Remington: The Science and Practice of Pharmacy, 20th edition, Lippincott, Williams, & Wilkins; Pharmaceutical Dosage Forms and Drug Delivery Systems (1999) H.C. Ansel et al., eds., 7th ed., Lippincott, Williams, & Wilkins; and Handbook of Pharmaceutical Excipients (2000) A.H. Kibbe et al., eds., 3rd ed. Amer. Pharmaceutical Assoc]을 포함하는 다양한 간행물에 충분히 기재되어 있다.
조성물을 제조하기 위해, rAAV 비리온이 생성되고, 필요하거나 원하는 대로 정제된다. rAAV는 약제학적으로 허용되는 담체와 혼합되거나, 또는 그 중에 현탁될 수 있다. 이들 rAAV는 적절한 농도로 조정될 수 있고, 임의로 다른 제제와 조합될 수 있다. 단위 용량에 포함된 rAAV 비리온 및/또는 기타 제제의 농도는 광범위하게 달라질 수 있다. 투여량 및 투여 횟수는 당업자에 의해 최적화될 수 있다. 예를 들면, 약 102-1010 벡터 게놈(vg)을 투여할 수 있다. 일부 실시양태에서, 용량은 적어도 약 102 vg, 약 103 vg, 약 104 vg, 약 105 vg, 약 106 vg, 약 107 vg, 약 108 vg, 약 109 vg, 약 1010 vg, 또는 그 이상의 벡터 게놈이다. 화합물의 일일 용량도 상이할 수 있다. 이러한 1일 용량은, 예를 들면, 약 102 vg/일, 약 103 vg/일, 약 104 vg/일 내지 약 105 vg/일, 약 106 vg/일, 약 107 vg/일, 약 108 vg/day, 약 109 vg/일, 약 1010 vg/일, 또는 그 이상의 벡터 게놈의 범위일 수 있다.
특정 실시양태에서, 치료 방법은 하나 이상의 항염증제, 예를 들면, 항염증 스테로이드 또는 비스테로이드 항염증 약물(NSAID)의 투여에 의해 증강된다.
본 발명에 사용하기 위한 항염증 스테로이드는 코르티코스테로이드, 특히 글루코코르티코이드 활성을 갖는 것, 예를 들면, 덱사메타손 및 프레드니손을 포함한다. 본 발명에 사용하기 위한 비스테로이드성 항염증 약물(NSAID)은 일반적으로 염증 및 통증을 유발하는 프로스타글란딘, 사이클로옥시게나제-1(COX-1) 및/또는 사이클로옥시게나제-2(COX-2)의 생성을 차단함으로써 작용한다. 종래의 NSAID는 COX-1과 COX-2를 모두 차단하여 기능한다. COX-2 선택적 억제제는 COX-2 효소만을 차단한다. 특정 실시양태에서, NSAID는 COX-2 선택적 억제제, 예를 들면, 셀레콕십(Celebrex®), 로페콕십(Vioxx) 및 발데콕십(B extra)이다. 특정 실시양태에서, 항염증제는 NSAID 프로스타글란딘 억제제, 예를 들면, 피록시캄이다.
치료에 사용하기 위한 rAAV 비리온의 양은 선택된 특정 담체뿐만 아니라, 투여 경로, 치료되는 상태의 특성 및 환자의 연령 및 상태에 따라 달라질 것이다. 최종적으로, 담당 의료 제공자가 적절한 용량을 결정할 수 있다. 약제학적 조성물은, 세포와 함께 또는 세포 없이 투여하기 위해, 단일 단위 투여 형태 중의 각 화합물의 적절한 비율로 제형화될 수 있다. 세포 또는 벡터는 별도로 제공될 수 있고, 화합물 조성물의 액체 용액과 혼합되거나, 또는 별도로 투여될 수 있다.
재조합 AAV는 비경구 투여용으로 제형화될 수 있고(예를 들면, 주사, 예를 들면, 볼루스 주사 또는 연속 주입에 의해), 앰플, 사전충전된 주사기, 소량 주입 용기 또는 방부제를 첨가한 복수회 용량 용기에 단위 투여 형태로 제공될 수 있다. 약제학적 조성물은 유성 또는 수성 비히클 중의 현탁액, 용액 또는 에멀젼의 형태를 취할 수 있고, 현탁제, 안정화제 및/또는 분산제 등의 배합제를 함유할 수 있다. 적합한 담체는 식염수 용액, 인산염 완충 식염수, 및 당해 기술분야에서 일반적으로 사용되는 기타 재료를 포함한다.
조성물은 또한, 예를 들면, 항응고제(예를 들면, 달테파린(프라그민), 다나파로이드(오르가란), 에녹사파린(로베녹스), 헤파린, 틴자파린(이노헵) 및/또는 와파린(쿠마딘)), 항혈소판제(예: 아스피린, 티클로피딘, 클로피도그렐 또는 디피리다몰), 안지오텐신 전환 효소 억제제(예: 베나제프릴(로텐신), 캅토프릴(카포텐), 에날라프릴(바소텍), 포시노프릴(모노프릴), 리시노프릴(프리니빌, 제스트릴), 모엑시프릴(유니바스크), 페린도프릴(아세온), 퀴나프릴(악쿠프릴), 라미프릴(알타세) 및/또는 트란돌라프릴(마빅)), 안지오텐신 II 수용체 차단제(예: 칸데사르탄(아타칸드), 에프로사르탄(테베텐), 이르베사르탄(아바프로), 로사르탄(코자아르), 텔미사르탄(미카르디스) 및/또는 발사르탄(디오반)), 베타 차단제(예: 아세부톨롤(섹트랄), 아테놀롤(네노르민), 베탁솔롤(케를론), 비소프롤롤/하이드로클로로티아지드(지악), 비소프롤롤(제베타), 카르테올롤(카르트롤), 메토프롤롤(로프레쏘르, 토프롤 XL), 나돌롤(코르가르드), 프로프라놀롤(인데랄), 소탈롤(베타파세) 및/또는 티몰롤(블라카드렌)), 칼슘 채널 차단제(예: 암로디핀(노르바스크, 로트렐), 베프리딜(바스코), 딜티아젬(카디젬, 티아작), 펠로디핀(플렌딜), 니페디핀(아달랏, 프로카르디아), 니모디핀(니모톱), 니솔디핀(술라), 베라파밀(칼란, 이소프틴, 베렐란)), 이뇨제(예: 아밀로라이드(미다모르), 부메타나이드(부멕스), 클로로티아지드(디우릴), 클로르탈리돈(하이그로톤), 푸로세미드(라식스), 하이드로-클로로티아지드(에시드릭스, 하이드로디우릴), 인다파미드(로졸) 및/또는 스피로놀락톤(알닥톤)), 혈관확장제(예: 이소소르비드 디니트레이트(이소르딜), 네시리티드(나트레코르), 하이드랄아진(아프레솔린), 니트레이트 및/또는 미녹시딜), 스타틴, 니코틴산, 겜피브로질, 클로피브레이트, 디곡신, 디기톡신, 라녹신 또는 이들의 조합 등의 심장 질환, 상태 및 손상의 치료에 유용한 약제 등의 기타 성분을 포함할 수 있다.
항균제, 항균제, 항바이러스제, 생물학적 반응 조절제, 성장 인자; 면역 조절제, 모노클로날 항체 및/또는 방부제 등의 추가 제제가 포함될 수도 있다. 본 발명의 조성물은 또한 다른 형태의 요법과 조합하여 사용될 수 있다.
본원에 기재된 rAAV 비리온은 질환 또는 장애를 치료하기 위해 대상체에게 투여될 수 있다. 이러한 조성물은, 예를 들면, 투여 목적이 외상성 손상에 대한 반응인지 또는 보다 지속적인 치료 목적 및 및 숙련된 개업의에게 공지된 기타 요인인지에 따라, 수용자의 생리학적 상태에 따라, 단일 용량, 다중 용량, 연속적 또는 간헐적 방식으로 존재할 수 있다. 본 발명의 화합물 및 조성물의 투여는 사전 선택된 기간에 걸쳐 본질적으로 연속적일 수 있거나, 또는 일련의 간격을 둔 용량일 수 있다. 국소 및 전신 투여가 모두 고려된다. 일부 실시양태에서, rAAV 비리온의 국소 전달이 달성된다. 일부 실시양태에서, rAAV 비리온의 국소 전달은 심장내 세포 집단을 생성하기 위해 사용된다. 일부 실시양태에서, 이러한 국소화 집단은 심장에 대한 "페이스메이커 세포"로서 기능한다. 일부 실시양태에서, rAAV 비리온은 동방(SA) 결절, 방실(AV) 결절, His의 번들, 및/또는 푸르키네(Purkinje) 섬유 중 하나 이상을 생성, 재생, 수복, 치환 및/또는 재결합시키기 위해 사용된다.
긴장성(tonicity)을 조절하기 위해, 수성 약제학적 조성물은 나트륨 염 등의 생리학적 염을 포함할 수 있다. 염화나트륨(NaCl)이 바람직하고, 이는 1 내지 20mg/ml로 존재할 수 있다. 존재할 수 있는 다른 염에는 염화칼륨, 인산이수소칼륨, 인산이나트륨 탈수화물, 염화마그네슘 및 염화칼슘이 포함된다.
조성물은 하나 이상의 완충액을 포함할 수 있다. 전형적인 완충액은 하기를 포함한다: 인산염 완충액; 트리스 완충액; 붕산염 완충액; 석시네이트 완충액; 히스티딘 완충액; 또는 시트레이트 완충액. 완충액은 통상 5-20mM 범위의 농도로 포함된다. 조성물의 pH는 일반적으로 5 내지 8, 보다 일반적으로 6 내지 8, 예를 들면, 6.5 내지 7.5, 또는 7.0 내지 7.8일 것이다.
조성물은 바람직하게는 멸균 상태이다. 조성물은 바람직하게는 글루텐을 함유하지 않는다. 조성물은 바람직하게는 비발열성이다.
일부 실시양태에서, 세포를 포함하는 조성물은 동결보호제를 포함할 수 있다. 동결보호제의 비제한적 예는 글리콜(예를 들면, 에틸렌 글리콜, 프로필렌 글리콜, 및 글리세롤), 디메틸 설폭사이드(DMSO), 포름아미드, 수크로스, 트레할로스, 덱스트로스, 및 이들의 임의의 조합을 포함한다.
다음 유형의 화합물 중 하나 이상이 또한 rAAV 비리온과 함께 조성물에 존재할 수 있다: WNT 효능제, GSK3 억제제, TGF-β 신호전달 억제제, 에피겐 변형제, LSD1 억제제, 아데닐릴 사이클라제 효능제, 또는 임의의 이들의 조합.
키트
본원에 기재된 임의의 조성물(예를 들면, rAAV 비리온)을 포함하는 다양한 키트가 본원에 기재된다. 키트는, 함께 혼합되거나 개별적으로 포장된, 건조 또는 수화된 형태로 본원에 기재된 임의의 조성물을 포함할 수 있다. 본원에 기재된 rAAV 비리온 및/또는 기타 제제는 개별 바이알, 병 또는 기타 용기에 별도로 포장될 수 있다. 또는, 본원에 기재된 rAAV 비리온 및/또는 임의의 약제를 단일 조성물로서, 또는 함께 또는 별도로 사용될 수 있는 2개 이상의 조성물로서 함께 패키징할 수 있다. 본원에 기재된 화합물 및/또는 약제는 적절한 비율 및/또는 양으로 패키징되어, 분화 경계를 초월하여 선택된 세포를 전환하여 심장 전구 세포 및/또는 심근세포를 형성하는 것을 용이하게 할 수 있다.
키트는 이러한 조성물, 화합물 및/또는 약제를 투여하기 위한 설명서를 포함할 수 있다. 이러한 지시는, 본 출원 전체에 설명된 정보를 제공할 수 있다. rAAV 비리온 또는 약제학적 조성물은 전달 장치의 형태로 임의의 키트 내에 제공될 수 있다. 또는, 전달 장치를 키트에 별도로 포함시킬 수 있고, 지시는 대상체에게 투여하기 전에 전달 장치를 조립하는 방법을 설명할 수 있다.
임의의 키트는 또한 주사기, 카테터, 메스, 샘플 또는 세포 수집용의 멸균 용기, 희석제, 약제학적으로 허용되는 담체 등을 포함할 수 있다. 키트는 이전 섹션 또는 본 출원의 다른 부분의 조성물에 대해 본원에 기재된 임의의 보충 인자 또는 약물 등의 기타 인자를 제공할 수 있다.
넘버링된 실시양태
실시양태 I-1. 하기를 포함하는 재조합 아데노-연관 바이러스(rAAV) 비리온:
a) AAV5 캡시드 단백질로서, 캡시드 단백질은 모 서열의 GH 루프의 삽입 부위에서 5 내지 11개 아미노산의 모 서열에 대한 삽입을 포함하는, AAV5 캡시드 단백질; 및
b) 유전자 산물을 암호화하는 뉴클레오티드 서열을 포함하는 이종 핵산.
실시양태 I-2. 실시양태 I-1에 있어서, 상기 rAAV 비리온이, 모 서열을 포함하는 AAV 비리온과 비교하여, 심장 세포에서 형질도입 효율의 증가를 나타내는, rAAV 비리온.
실시양태 I-3. 실시양태 I-1에 있어서, 상기 rAAV 비리온이, 모 서열을 포함하는 AAV 비리온과 비교하여, 인간 심장 섬유아세포(hCF) 세포에서 형질도입 효율의 증가를 나타내는, rAAV 비리온.
실시양태 I-4. 실시양태 I-3에 있어서, 상기 rAAV 비리온이 1,000의 감염 다중도(MOI)에서 hCF 세포에서 적어도 10배 증가된 형질도입 효율을 나타내는, rAAV 비리온.
실시양태 I-5. 실시양태 I-3에 있어서, 상기 rAAV 비리온이 100,000의 감염 다중도(MOI)에서 hCF 세포에서 적어도 2배 증가된 형질도입 효율을 나타내는, rAAV 비리온.
실시양태 I-6. 실시양태 I-1에 있어서, 상기 rAAV 비리온이, 모 서열을 포함하는 AAV 비리온과 비교하여, 유도 만능 줄기 세포-유래 심근세포(iPS-CM) 세포에서 형질도입 효율의 증가를 나타내는, rAAV 비리온.
실시양태 I-7. 실시양태 I-6에 있어서, 상기 rAAV 비리온이 100,000의 감염 다중도(MOI)에서 iPS-CM 세포에서 적어도 2배 증가된 형질도입 효율을 나타내는, rAAV 비리온.
실시양태 I-8. 실시양태 I-6에 있어서, 상기 rAAV 비리온이 1,000의 감염 다중도(MOI)에서 iPS-CM 세포에서 적어도 4배 증가된 형질도입 효율을 나타내는, rAAV 비리온.
실시양태 I-9. 실시양태 I-1에 있어서, 상기 rAAV 비리온이, iPS-CM 세포보다도 hCF 세포에 대한 rAAV 비리온의 선택성의 증가를 나타내는, rAAV 비리온.
실시양태 I-10. 실시양태 I-1에 있어서, 상기 rAAV 비리온이 hCF 세포보다도 iPS-CM 세포에 대한 rAAV 비리온의 선택성의 증가를 나타내는, rAAV 비리온.
실시양태 I-11. 실시양태 I-1에 있어서, 상기 삽입 부위가, 서열번호 1의 560 내지 594에 대응하는 모 서열 내의 위치에서 임의의 2개의, 임의로 인접한 아미노산 사이에 있는, rAAV 비리온.
실시양태 I-12. 실시양태 I-11에 있어서, 상기 삽입 부위가 서열번호 1의 574 및 575에 대응하는 모 서열 내의 인접한 아미노산 사이에 있는, rAAV 비리온.
실시양태 I-13. 실시양태 I-12에 있어서, 상기 삽입이 하기 식의 펩티드인, rAAV 비리온:
-X0-(X)n-X10-
상기 식에서,
n은 5-9이고,
X0 및 X10은 각각 독립적으로 A, S, G 또는 부재한다(서열번호 1101).
실시양태 I-14. 실시양태 I-12에 있어서, 상기 삽입이 하기 식의 펩티드인, rAAV 비리온:
-X0-X1-X2-X3-X4-X5-X6-X7-X8-
상기 식에서, X0 및 X8은 각각 독립적으로 A, S, G 또는 부재한다(서열번호 1102).
실시양태 I-15. 실시양태 I-12에 있어서, 상기 삽입이 하기 식의 펩티드인, rAAV 비리온:
-A-X1-X2-X3-X4-X5-X6-X7-A-
상기 식에서:
a) X1은 P, R 또는 G이고;
b) X2는 K, L 또는 R이고;
c) X3은 임의의 아미노산이고;
d) X4는 N, H, K, 또는 Q이고;
e) X5는 임의의 아미노산이거나, 또는 임의로 X5는 G, K 또는 S이고;
f) X6은 임의의 아미노산이거나, 임의로 X6은 T 또는 V이고;
g) X7은 임의의 아미노산이거나, 임의로 X7은 K 또는 V이다(서열번호 1103).
실시양태 I-실시양태 I-16. 실시양태 I-14에 있어서, 상기 삽입이 서열번호 101-600으로부터 선택된 아미노산 서열을 포함하는, rAAV 비리온.
실시양태 I-17. 실시양태 I-14에 있어서, 상기 삽입이 RKVHIEV(서열번호 81), RKYQSDL(서열번호 82), PLTNTVK(서열번호 83), LKYHGPP(서열번호 84), RKYQGDM(서열번호 85), RKFHSTD(서열번호 86), RKHHGLE(서열번호 87), PGTNVTK(서열번호 88), RKMHMPD(서열번호 89), PLKKIVQ(서열번호 90), PLGKKTS(서열번호 91), PRGVKVT(서열번호 92), PLAKSKS(서열번호 93), PRTKGAV(서열번호 94), PSGRKAT(서열번호 95)로부터 선택된 아미노산 서열을 포함하는, rAAV 비리온.
실시양태 I-18. 실시양태 I-14에 있어서, 상기 삽입이 ARKVHIEVA(서열번호 101), ARKYQSDLA(서열번호 102), APLTNTVKA(서열번호 103), ALKYHGPPA(서열번호 104), ARKYQGDMA(서열번호 105), ARKFHSTDA(서열번호 106), ARKHHGLEA(서열번호 107), APGTNVTKA(서열번호 108), ARKMHMPDA(서열번호 109), APLKKIVQA(서열번호 110), APLGKKTSA(서열번호 111), APRGVKVTA(서열번호 112), APLAKSKSA(서열번호 113), APRTKGAVA(서열번호 114), APSGRKATA(서열번호 115)로부터 선택된 아미노산 서열을 포함하는, rAAV 비리온.
실시양태 I-19. 실시양태 I-14에 있어서, 상기 삽입이 아미노산 서열 PLTNTVK(서열번호 83), 또는 PLTNTVK(서열번호 83)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함하는, rAAV 비리온.
실시양태 I-20. 실시양태 I-14에 있어서, 상기 삽입이 아미노산 서열 PLKKIVQ(서열번호 90), 또는 PLKKIVQ(서열번호 90)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함하는, rAAV 비리온.
실시양태 I-21. AAV5 캡시드 단백질로서, 상기 캡시드 단백질은 모 서열의 GH 루프의 삽입 부위에서 5 내지 11개 아미노산의 모 서열에 대한 삽입을 포함하는, AAV5 캡시드 단백질.
실시양태 I-22. 실시양태 I-21에 있어서, 상기 AAV5 캡시드 단백질이, 모 서열을 포함하는 AAV 비리온과 비교하여, 심장 세포에서 형질도입 효율의 증가를 나타내는, AAV5 캡시드 단백질.
실시양태 I-23. 실시양태 I-21에 있어서, 상기 AAV5 캡시드 단백질이, 모 서열을 포함하는 AAV 비리온과 비교하여, 인간 심장 섬유아세포(hCF) 세포에서 형질도입 효율의 증가를 나타내는, AAV5 캡시드 단백질.
실시양태 I-24. 실시양태 I-23에 있어서, 상기 AAV5 캡시드 단백질이 1,000의 감염 다중도(MOI)에서 hCF 세포에서 적어도 10배 증가된 형질도입 효율을 나타내는, AAV5 캡시드 단백질.
실시양태 I-25. 실시양태 I-23에 있어서, 상기 AAV5 캡시드 단백질이 100,000의 감염 다중도(MOI)에서 hCF 세포에서 적어도 2배 증가된 형질도입 효율을 나타내는, AAV5 캡시드 단백질.
실시양태 I-26. 실시양태 I-21에 있어서, 상기 AAV5 캡시드 단백질이 모 서열을 포함하는 AAV 비리온과 비교하여, 유도 만능 줄기 세포-유래 심근세포(iPS-CM) 세포에서 형질도입 효율의 증가를 나타내는, AAV5 캡시드 단백질.
실시양태 I-27. 실시양태 I-26에 있어서, 상기 AAV5 캡시드 단백질이 100,000의 감염 다중도(MOI)에서 iPS-CM 세포에서 적어도 2배 증가된 형질도입 효율을 나타내는, AAV5 캡시드 단백질.
실시양태 I-28. 실시양태 I-26에 있어서, 상기 AAV5 캡시드 단백질이 1,000의 감염 다중도(MOI)에서 iPS-CM 세포에서 적어도 4배 증가된 형질도입 효율을 나타내는, AAV5 캡시드 단백질.
실시양태 I-29. 실시양태 I-21에 있어서, 상기 AAV5 캡시드 단백질이 iPS-CM 세포보다도 hCF 세포에 대한 AAV5 캡시드 단백질의 선택성의 증가를 나타내는, AAV5 캡시드 단백질.
실시양태 I-30. 실시양태 I-21에 있어서, 상기 AAV5 캡시드 단백질이 hCF 세포보다도 iPS-CM 세포에 대한 AAV5 캡시드 단백질의 선택성의 증가를 나타내는, AAV5 캡시드 단백질.
실시양태 I-31. 실시양태 I-21에 있어서, 상기 삽입 부위가 서열번호 1의 560 내지 594에 대응하는 모 서열 내의 위치에서 임의의 2개의, 임의로 인접한 아미노산 사이에 있는, AAV5 캡시드 단백질.
실시양태 I-32. 실시양태 I-21에 있어서, 상기 삽입 부위가 서열번호 1의 574 및 575에 대응하는 모 서열 내의 인접한 아미노산 사이에 있는, AAV5 캡시드 단백질.
실시양태 I-33. 실시양태 I-32에 있어서, 상기 삽입이 하기 식의 펩티드인, AAV5 캡시드 단백질:
-X0-(X)n-X10-
상기 식에서, n은 5-9이고,
X0 및 X10은 각각 독립적으로 A, S, G 또는 부재한다(서열번호 1101).
실시양태 I-34. 실시양태 I-32에 있어서, 상기 삽입이 하기 식의 펩티드인, AAV5 캡시드 단백질:
-X0-X1-X2-X3-X4-X5-X6-X7-X8-
상기 식에서, X0 및 X8은 각각 독립적으로 A, S, G 또는 부재한다(서열번호 1102).
실시양태 I-35. 실시양태 I-32에 있어서, 상기 삽입이 하기 식의 펩티드인, AAV5 캡시드 단백질:
-A-X1-X2-X3-X4-X5-X6-X7-A-
상기 식에서,
a) X1은 P, R 또는 G이고;
b) X2는 K, L 또는 R이고;
c) X3은 임의의 아미노산이고;
d) X4는 N, H, K, 또는 Q이고;
e) X5는 임의의 아미노산이거나, 또는 임의로 X5는 G, K 또는 S이고;
f) X6은 임의의 아미노산이거나, 임의로 X6은 T 또는 V이고;
g) X7은 임의의 아미노산이거나, 임의로 X7은 K 또는 V이다(서열번호 1103).
실시양태 I-36. 실시양태 I-34에 있어서, 상기 삽입이 서열번호 101-600으로부터 선택된 아미노산 서열을 포함하는, AAV5 캡시드 단백질.
실시양태 I-37. 실시양태 I-34에 있어서, 상기 삽입이 RKVHIEV(서열번호 81), RKYQSDL(서열번호 82), PLTNTVK(서열번호 83), LKYHGPP(서열번호 84), RKYQGDM(서열번호 85), RKFHSTD(서열번호 86), RKHHGLE(서열번호 87), PGTNVTK(서열번호 88), RKMHMPD(서열번호 89), PLKKIVQ(서열번호 90), PLGKKTS(서열번호 91), PRGVKVT(서열번호 92), PLAKSKS(서열번호 93), PRTKGAV(서열번호 94), PSGRKAT(서열번호 95)83)로부터 선택된 아미노산 서열을 포함하는, AAV5 캡시드 단백질.
실시양태 I-38. 실시양태 I-34에 있어서, 상기 삽입이 ARKVHIEVA(서열번호 101), ARKYQSDLA(서열번호 102), APLTNTVKA(서열번호 103), ALKYHGPPA(서열번호 104), ARKYQGDMA(서열번호 105), ARKFHSTDA(서열번호 106), ARKHHGLEA(서열번호 107), APGTNVTKA(서열번호 108), ARKMHMPDA(서열번호 109), APLKKIVQA(서열번호 110), APLGKKTSA(서열번호 111), APRGVKVTA(서열번호 112), APLAKSKSA(서열번호 113), APRTKGAVA(서열번호 114), APSGRKATA(서열번호 115)101)로부터 선택된 아미노산 서열을 포함하는, AAV5 캡시드 단백질.
실시양태 I-39. 실시양태 I-34에 있어서, 상기 삽입이 아미노산 서열 PLTNTVK(서열번호 83), 또는 PLTNTVK(서열번호 83)에 대해 최대 1, 2, 3 또는 4개의 아미노산 치환을 포함하는 서열을 포함하는, AAV5 캡시드 단백질.
실시양태 I-40. 실시양태 I-34에 있어서, 상기 삽입이 아미노산 서열 PLKKIVQ(서열번호 90), 또는 PLKKIVQ(서열번호 90)에 대해 최대 1, 2, 3 또는 4개의 아미노산 치환을 포함하는 서열을 포함하는, AAV5 캡시드 단백질.
실시양태 I-41. 실시양태 I-21 내지 I-40 중 어느 한 실시양태의 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드.
실시양태 I-42. 실시양태 I-1 내지 I-20 중 어느 한 실시양태에 따른 rAAV 비리온을 포함하는 약제학적 조성물.
실시양태 I-43. 심장 세포를 실시양태 I-1 내지 I-20 중 어느 한 실시양태에 따른 rAAV 비리온과 접촉시키는 것을 포함하는, 심장 세포를 형질도입하는 방법으로서, 상기 rAAV 비리온이 심장 세포를 형질도입하는, 방법.
실시양태 I-44. 심장 세포를 실시양태 I-1 내지 I-20 중 어느 한 실시양태에 따른 rAAV 비리온과 접촉시키는 것을 포함하는, 하나 이상의 유전자 산물을 심장 세포에 전달하는 방법으로서, 상기 심장 세포가 유전자 산물을 발현하는, 방법.
실시양태 I-45. 실시양태 I-44에 있어서, 상기 하나 이상의 유전자 산물이 숏-헤어핀 RNA 또는 마이크로RNA를 포함하는, 방법.
실시양태 I-46. 실시양태 I-44에 있어서, 상기 하나 이상의 유전자 산물이 가이드 RNA, Cas 단백질, 및 임의로 수복 주형을 포함하고, 상기 유전자 산물이 기능적 CRISPR/Cas 시스템을 형성하는, 방법.
실시양태 I-47. 실시양태 I-44에 있어서, 상기 하나 이상의 유전자 산물이 폴리펩티드를 포함하는, 방법.
실시양태 I-48. 실시양태 I-47에 있어서, 상기 폴리펩티드가, 심장 트로포닌 T; 심장 근육 단백질; β-미오신 중쇄; 미오신 심실 필수 경쇄 1; 미오신 심실 조절 경쇄 2; 심장 α-액틴; α-트로포미오신; 심장 트로포닌 I; 심장 미오신 결합 단백질 C; 4.5 LIM 단백질 1; 티틴; 5'-AMP 활성화 단백질 키나제 서브유닛 감마-2; 트로포닌 I 유형 3, 미오신 경쇄 2, 액틴 알파 심장 근육 1; 심장 LIM 단백질; 카베올린 3(CAV3); 갈락토시다제 알파(GLA); 리소좀-관련 막 단백질 2(LAMP2); 미토콘드리아 전달 RNA 글리신(MTTG); 미토콘드리아 전달 RNA 이소류신(MTTI); 미토콘드리아 전달 RNA 라이신(MTTK); 미토콘드리아 전달 RNA 글루타민(MTTQ); 미오신 경쇄 3(MYL3); 트로포닌 C(TNNC1); 트랜스티레틴(TTR); 근소포체 칼슘-ATPase 2a(SERCA2a); 간질 유래 인자-1(SDF-1); 아데닐레이트 사이클라제-6(AC6); β-ARKct(β-아드레날린 수용체 키나제 C 말단); 섬유아세포 성장 인자(FGF); 혈소판 유래 성장 인자(PDGF); 혈관 내피 성장 인자(VEGF); 간세포 성장 인자; 저산소증 유도성 성장 인자; 티모신 베타 4(TMSB4X); 산화질소 신타제-3(NOS3); 아포리포단백질-E(ApoE); 및 슈퍼옥사이드 디스뮤타제(SOD); S100A1로부터 선택되는, 방법,
실시양태 I-49. 실시양태 I-44에 있어서, 하나 이상의 유전자 산물이 하나 이상의 재프로그래밍 인자를 포함하는 것인 방법.
실시양태 I-50. 실시양태 I-49에 있어서, 상기 하나 이상의 재프로그래밍 인자가 ASCL1, MYOCD, MEF2C, TBX5, CCNB1, CCND1, CDK1, CDK4, AURKB, OCT4, BAF60C, ESRRG, GATA4, GATA6, HAND2, IRX4, ISLL, MESP1, MESP2, NKX2.5, SRF, TBX20 및 ZFPM2로부터 선택된 하나 이상의 폴리펩티드인, 방법.
실시양태 I-51. 실시양태 I-43 내지 I-50 중 어느 한 실시양태에 있어서, 상기 방법이 심장 세포를 심장 심근세포로 재프로그래밍하는, 방법.
실시양태 I-52. 치료학적 유효량의 실시양태 I-42에 따른 약제학적 조성물을 대상체에게 투여하는 것을 포함하는, 이를 필요로 하는 대상체에서 심장 병리를 치료하는 방법으로서, 상기 rAAV 비리온이 심장 조직을 형질도입하는, 방법.
실시양태 I-53. 실시양태 I-52에 있어서, 상기 rAAV 비리온이 피하, 정맥내, 심외막, 근육내, 복강내, 또는 심장내 주사에 의해 또는 심장내 카테터삽입에 의해 투여되는, 방법.
실시양태 I-54. 실시양태 I-52에 있어서, 상기 rAAV 비리온이 직접 심근내 주사 또는 경혈관 투여에 의해 투여되는, 방법.
실시양태 I-55. 실시양태 I-52에 있어서, 상기 rAAV 비리온이 직접 심근내 주사, 순행성 관상동맥내 주사, 역행성 주사, 경심내막 주사 또는 재순환 전달을 수반하는 분자 심장 수술(MCARD)에 의해 투여되는, 방법.
실시양태 I-56. 표적 세포에서 형질도입 효율의 증가를 rAAV 비리온에 부여하는 AAV 캡시드 단백질을 동정하는 방법으로서,
a) rAAV 게놈이 변이체 AAV 캡시드 단백질을 암호화하는 cap 폴리뉴클레오티드의 라이브러리를 포함하는 rAAV 비리온의 집단을 제공하는 단계;
b) rAAV 비리온에 의해 cap 폴리뉴클레오티드의 표적 세포 내로의 형질도입을 허용하기에 충분한 시간 동안 집단을 표적 세포와 접촉시키는 단계; 및
c) 표적 세포로부터 cap 폴리뉴클레오티드를 서열분석하여, 표적 세포에서 형질도입 효율의 증가를 부여하는 AAV 캡시드 단백질을 동정하는 단계
를 포함하는, 방법.
실시양태 I-57. 실시양태 I-56에 있어서, 단계 (b) 전에, rAAV 비리온의 비-표적 세포로의 부착을 허용하기에 충분한 시간 동안 집단을 비-표적 세포와 접촉시킴으로써 rAAV 비리온의 집단을 고갈시키는 단계를 추가로 포함하는, 방법.
실시양태 I-58. 재조합 아데노-연관 바이러스(rAAV) 비리온으로서,
a) AAV5 캡시드 단백질로서, 상기 캡시드 단백질은, 모 AAV5 캡시드와 비교하여, S651A, T578A, 또는 T582A로부터 선택된 하나 이상의 치환을 포함하는, AAV5 캡시드 단백질; 및
b) 유전자 산물을 암호화하는 뉴클레오티드 서열을 포함하는 이종 핵산
을 포함하는, 재조합 아데노-연관 바이러스(rAAV) 비리온.
실시양태 I-59. 실시양태 I-58에 있어서, 상기 AAV5 캡시드 단백질이 S651A, T578A 또는 T582A로부터 선택된 2개 이상의 치환을 포함하는, rAAV 비리온.
실시양태 I-60. 실시양태 I-58에 있어서, 상기 AAV5 캡시드 단백질이 T582A 및 S651A 치환을 포함하는, rAAV 비리온.
실시양태 I-61. 실시양태 I-58에 있어서, 상기 AAV5 캡시드 단백질이 T578A 및 T582A 치환을 포함하는, rAAV 비리온.
실시양태 I-62. 실시양태 I-58에 있어서, 상기 AAV5 캡시드 단백질이 T578A 및 S651A 치환을 포함하는, rAAV 비리온.
실시양태 I-63. 실시양태 I-58에 있어서, 상기 AAV5 캡시드 단백질이 S651A, T578A, 및 T582A 치환을 포함하는, rAAV 비리온.
실시양태 I-64. 실시양태 I-58 내지 I-62 중 어느 한 실시양태에 있어서, 상기 AAV5 캡시드 단백질이 서열번호 73에 대해 적어도 95% 동일성을 공유하는, rAAV 비리온.
실시양태 I-65. 실시양태 I-58 내지 I-62 중 어느 한 실시양태에 있어서, 상기 AAV5 캡시드 단백질이 서열번호 73에 대해 적어도 98% 동일성을 공유하는, rAAV 비리온.
실시양태 I-66. 실시양태 I-58 내지 I-62 중 어느 한 실시양태에 있어서, 상기 AAV5 캡시드 단백질이 서열번호 73에 대해 적어도 99% 동일성을 공유하는, rAAV 비리온.
실시양태 I-67. 실시양태 I-58 내지 I-62 중 어느 한 실시양태에 있어서, 상기 AAV5 캡시드 단백질이 서열번호 73의 폴리펩티드 서열을 포함하는, rAAV 비리온.
실시양태 I-68. 모 AAV5 캡시드와 비교하여, S651A, T578A, 또는 T582A로부터 선택된 하나 이상의 치환을 포함하는, AAV5 캡시드 단백질.
실시양태 I-69. 실시양태 I-67에 있어서, 상기 캡시드 단백질이 S651A, T578A 또는 T582A로부터 선택된 2개 이상의 치환을 포함하는, AAV5 캡시드 단백질.
실시양태 I-70. 실시양태 I-67에 있어서, 상기 캡시드 단백질이 T582A 및 S651A 치환을 포함하는, AAV5 캡시드 단백질.
실시양태 I-71. 실시양태 I-68에 있어서, 상기 캡시드 단백질이 T578A 및 T582A 치환을 포함하는, AAV5 캡시드 단백질.
실시양태 I-72. 실시양태 I-68에 있어서, 상기 캡시드 단백질이 T578A 및 S651A 치환을 포함하는, AAV5 캡시드 단백질.
실시양태 I-73. 실시양태 I-68에 있어서, 상기 캡시드 단백질이 S651A, T578A, 및 T582A 치환을 포함하는, AAV5 캡시드 단백질.
실시양태 I-74. 실시양태 I-68 내지 I-73 중 어느 한 실시양태에 있어서, 상기 캡시드 단백질이 서열번호 73에 대해 90% 이상의 동일성을 공유하는, AAV5 캡시드 단백질.
실시양태 I-75. 실시양태 I-68 내지 I-73 중 어느 한 실시양태에 있어서, 상기 캡시드 단백질이 서열번호 73에 대해 적어도 95% 동일성을 공유하는, AAV5 캡시드 단백질.
실시양태 I-76. 실시양태 I-68 내지 I-73 중 어느 한 실시양태에 있어서, 상기 캡시드 단백질이 서열번호 73에 대해 적어도 98% 동일성을 공유하는, AAV5 캡시드 단백질.
실시양태 I-77. 실시양태 I-68 내지 I-73 중 어느 한 실시양태에 있어서, 상기 캡시드 단백질이 서열번호 73에 대해 적어도 99% 동일성을 공유하는, AAV5 캡시드 단백질.
실시양태 I-78. 실시양태 I-68 내지 I-77 중 어느 한 실시양태의 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드.
실시양태 I-79. 실시양태 I-58 내지 I-67 중 어느 한 실시양태의 rAAV 비리온을 포함하는 약제학적 조성물.
실시양태 I-80. 심장 세포를, 실시양태 I-58 내지 I-67 중 어느 한 실시양태에 따른 rAAV 비리온과 접촉시키는 것을 포함하는, 심장 세포를 형질도입하는 방법으로서, 상기 rAAV 비리온이 심장 세포를 형질도입하는, 방법.
실시양태 I-81. 실시양태 I-58 내지 I-67 중 어느 한 실시양태에 따른 rAAV 비리온과 심장 세포를 접촉시키는 것을 포함하는, 하나 이상의 유전자 산물을 심장 세포에 전달하는 방법으로서, 상기 심장 세포가 유전자 산물을 발현하는, 방법.
실시양태 I-82. 실시양태 I-81에 있어서, 상기 하나 이상의 유전자 산물이 숏-헤어핀 RNA 또는 마이크로RNA를 포함하는, 방법.
실시양태 I-83. 실시양태 I-81에 있어서, 상기 하나 이상의 유전자 산물이 가이드 RNA, Cas 단백질, 및 임의로 수복 주형을 포함하고, 상기 유전자 산물이 기능적 CRISPR/Cas 시스템을 형성하는, 방법.
실시양태 I-84. 실시양태 I-81에 있어서, 상기 하나 이상의 유전자 산물이 폴리펩티드를 포함하는, 방법.
실시양태 I-85. 실시양태 I-84에 있어서, 폴리펩티드가, 심장 트로포닌 T; 심장 근육 단백질; β-미오신 중쇄; 미오신 심실 필수 경쇄 1; 미오신 심실 조절 경쇄 2; 심장 α-액틴; α-트로포미오신; 심장 트로포닌 I; 심장 미오신 결합 단백질 C; 4.5 LIM 단백질 1; 티틴; 5'-AMP 활성화 단백질 키나제 서브유닛 감마-2; 트로포닌 I 유형 3, 미오신 경쇄 2, 액틴 알파 심장 근육 1; 심장 LIM 단백질; 카베올린 3(CAV3); 갈락토시다제 알파(GLA); 리소좀-관련 막 단백질 2(LAMP2); 미토콘드리아 전달 RNA 글리신(MTTG); 미토콘드리아 전달 RNA 이소류신(MTTI); 미토콘드리아 전달 RNA 라이신(MTTK); 미토콘드리아 전달 RNA 글루타민(MTTQ); 미오신 경쇄 3(MYL3); 트로포닌 C(TNNC1); 트랜스티레틴(TTR); 근소포체 칼슘-ATPase 2a(SERCA2a); 간질 유래 인자-1(SDF-1); 아데닐레이트 사이클라제-6(AC6); β-ARKct(β-아드레날린 수용체 키나제 C 말단); 섬유아세포 성장 인자(FGF); 혈소판 유래 성장 인자(PDGF); 혈관 내피 성장 인자(VEGF); 간세포 성장 인자; 저산소증 유도성 성장 인자; 티모신 베타 4(TMSB4X); 산화질소 신타제-3(NOS3); 아포리포단백질-E(ApoE); 및 슈퍼옥사이드 디스뮤타제(SOD); S100A1로부터 선택되는, 방법.
실시양태 I-86. 실시양태 I-81에 있어서, 상기 하나 이상의 유전자 산물이 하나 이상의 재프로그래밍 인자를 포함하는, 방법.
실시양태 I-87. 실시양태 I-86에 있어서, 상기 하나 이상의 재프로그래밍 인자가 ASCL1, MYOCD, MEF2C, TBX5, CCNB1, CCND1, CDK1, CDK4, AURKB, OCT4, BAF60C, ESRRG, GATA4, GATA6, HAND2, IRX4, ISLL, MESP1, MESP2, NKX2.5, SRF, TBX20 및 ZFPM2로부터 선택된 하나 이상의 폴리펩티드인, 방법.
실시양태 I-88. 실시양태 I-80 내지 I-87 중 어느 한 실시양태에 있어서, 상기 방법이 심장 세포를 심장 심근세포로 재프로그래밍하는, 방법.
실시양태 I-89. 실시양태 I-79에 따른 약제학적 조성물의 치료 유효량을 대상체에게 투여하는 것을 포함하는, 이를 필요로 하는 대상체에서 심장 병리를 치료하는 방법으로서, 상기 rAAV 비리온이 심장 조직을 형질도입하는, 방법.
실시양태 I-89. 실시양태 I-89에 있어서, 상기 rAAV 비리온이 피하, 심외막, 정맥내, 근육내, 복강내, 또는 심장내 주사에 의해 또는 심장내 카테터삽입에 의해 투여되는, 방법.
실시양태 I-90. 실시양태 I-89에 있어서, 상기 rAAV 비리온이 직접 심근내 주사 또는 경혈관 투여에 의해 투여되는, 방법.
실시양태 I-91. 실시양태 I-89에 있어서, 상기 rAAV 비리온이 직접 심근내 주사, 순행성 관상동맥내 주사, 역행성 주사, 경내막 주사, 또는 재순환 전달을 수반한 분자 심장 수술 (MCARD)에 의해 투여되는, 방법.
하기 비제한적 실시예는 본 발명의 개발에 관여하는 실험적 연구의 일부를 설명한다.
실시예
실시예 1: 캡시드 단백질 서열의 동정
라이브러리 생성 및 AAV 선택
유도 만능 줄기 세포-유래 심근세포(iPSC-CM)에 대한 초기 음성 선택 단계, 및 이어서 인간 심장 섬유아세포(hCF)에 대한 양성 선택 단계를 포함하는 라이브러리 스크리닝 전략을 도 1에 도시된 바와 같이 수행했다. 간단히 말해서, cap 유전자 서열의 라이브러리는 프라이머 P1(GTCGGCGGGCAGATGGCCACCAACAACCAGGCCNNKNNKNNKNNNKNNKNNKGCAGCTCCACCACTGCCCCCGCGACCGGCACG)(서열번호 6) 및 P2(TCCCCAGCATGAGCGATGCATTTTATTGAGGGTATGCGAC)(서열번호 7){N = A, C, G 또는 T; K = G 또는 T}을 사용하여 PCR에 의해 생성하고, 깁슨(Gibson) 어셈블리를 통해 NotI 및 NheI 선형화된 pCR-AAV-LIB575로 클로닝했다(도 2A). pCR-AAV-LIB575는 HEK293T 패키징 세포주를 사용하여 rAAV 비리온으로 패키징되었다. 이 벡터에는, AAV2의 rep 유전자("Rep2")와, 3' 및 5' 역방향 말단 반복서열(ITR)이 인접하는 AAV의 cap 유전자("Cap5")가 포함되어 있다. 알라닌 잔기(AXXXXXXA; 서열번호 100)에 인접하는 랜덤 7-mer 폴리펩티드 라이브러리는 cap 유전자의 위치 575에 삽입된다. 도 2B는 조립된 AAV 비리온 상에 존재하는 캡시드 단백질의 60개 카피 중 하나에 표시된 삽입 부위를 나타내는 흑색 화살표를 수반하는 AAV5 캡시드의 구조를 나타낸다. cap 유전자로의 삽입에 의해, 동일한 폴리펩티드가 모든 60개 카피에서 동일한 위치에 삽입된다(도면에 제시되지 않음).
50,000(라운드 1)에서 1,000(라운드 3) 범위의 감염 다중도의 비리온을 액체 배양 배지에서 혼합하고, 건강한 30세 남성으로부터 분리된 iPS-CM 세포에 적용했다. 세포를 37℃ 및 5% CO2에서 24시간 동안 인큐베이팅했다. DNA를 iPS-CM 세포로부터 단리하고, 프라이머 P2(서열번호 7) 및 P3(CCATCGACGTCAGACGCGGAAGCTTCGATCAACTACGCAGACAG)(서열번호 8)을 사용하여 PCR에 의해 증폭하고, 제조업체의 지시에 따라 Oxford NanoPore MiniION을 사용하여 서열분석했다. 이 음성 선택 단계에 대한 서열분석 판독을 분석했다(데이터는 제시되지 않음).
이어서, iPS-CM 세포에 부착되거나 감염되지 않은 rAAV 비리온을 함유하는 배양 배지를 hCF 세포로 옮기고, 37℃ 및 5% CO2에서 24시간 동안 인큐베이팅했다. 24시간 후, 플레이트를 배양 배지로 세척하고, 부착된 hCF 세포를 제거하고, cap 유전자의 PCR 증폭 및 서열분석을, 상기 기재된 바와 같이 rAAV로 감염된 hCF 세포로부터 단리된 DNA에 대해 수행했다. 서열의 개시 라이브러리 및 이 제1 라운드의 음성 및 양성 선택 후의 서열의 대표적 데이터는 각각 도 3A 및 도 3B에 제시되어 있다. 고유한 판독 비율이 97.6%로부터 87.5%로 감소했기 때문에, 선택된 서열의 농후화와 일치하여, 라이브러리 복잡성이 감소되었다.
최초 라운드에서 수득된 cap 유전자 라이브러리를 다시 pCR-AAV-LIB575에 서브클로닝하고, 라운드 2로서 동일한 음성 및 양성 선택 절차를 실행했다. 이를 라운드 3으로서 반복했다. 서열의 계속적 농후화는, 라운드 2(도 3C)로부터 라운드 3(도 3D)로의 고유 판독에서 58.2%로부터 41.5%로의 감소에 의해 관찰되었다.
시험관내 시스템에서 형질도입 효율 증가의 확인
각각의 고유 서열에 대한 판독 수는, 그 삽입 서열을 함유하는 rAAV 비리온의 형질도입 효율의 증가와 상관되어 있기 때문에, 판독의 농후화는 형질도입 효율의 증가의 실험적 측정이다. 하기 표 2에 최고 존재량을 갖는 500개 서열을 제공한다.
표 1에 수록된 서열은, GFP 리포터 검정을 사용하여, 배양된 hCF 세포(도 4A-4D) 및 iPS-CM 세포(도 5A-5D)에서 재시험하기 위해 선택되었다.
재시험된 삽입 서열
서열번호 펩티드 변이체 명칭 3 라운드 후의 hCF 라이브러리에서의 표현(%) 모 라이브러리에서의 표현(%) 농후화
(배수 증가)
101 ARKVHIEVA CR2 5.4328 0.0022 2469
102 ARKYQSDLA CR5 1.6044 0.0045 357
103 APLTNTVKA CR17 1.1055 0.0015 737
104 ALKYHGPPA CR18 0.9983 0.0015 666
105 ARKYQGDMA CR19 0.8591 0.0007 1227
106 ARKFHSTDA CR20 0.8368 0.0004 2092
107 ARKHHGLEA CR8 0.7068 0.0007 1010
108 APGTNVTKA CR21 0.6159 0.0041 150
109 ARKMHMPDA CR22 0.601 0 n/d
110 APLKKIVQA CR23 0.3165 0.0015 211
111 APLGKKTSA CR24 0.2339 0.0004 585
112 APRGVKVTA CR25 0.2223 0 n/d
113 APLAKSKSA CR26 0.1448 0.0004 362
114 APRTKGAVA CR27 0.1443 0.0004 361
115 APSGRKATA CR28 0.1146 0.0004 287
n/d = 측정하지 않음(not determined)
간단히 말해서, 표 1의 펩티드는 각각, 선택 실험에서와 같이 AAV 게놈이 아니라, 역방향 말단 반복서열(ITR)을 결여하는 Rep-Cap 플라스미드의 동일한 삽입 부위에서 cap 유전자에 클로닝시켰다. 이러한 Rep-Cap 플라스미드는, 리포터 AAV 게놈(CAG 프로모터에 의해 조절되는 GFP 도입유전자에 인접하는 AAV2 ITR)을 패키징하는 rAAV를 생성하기 위해, 각각 Rep2 및 각각의 Cap 변이체를 발현시키기 위해 사용되었다. 캡시드로서 조작된 캡시드 단백질을 갖는 GFP 도입유전자를 함유하는 수득된 rAAV 비리온을, 100,000(도 4A, 도 5A, 도 5D) 또는 1,000(도 4D)의 MOI에서 부착성 hCF 또는 iPS-CM 세포에 플레이팅했다. 형질도입 효율은, Cytation 5™ 세포 이미징 다중 모드 판독기를 구비한 자동 디지털 광시야 현미경을 사용하여 GFP 형광 세포를 계수함으로써 측정했다. 대표적 형광 현미경 사진을 (도 4B; 모 AAV5 캡시드 - 서열번호 1) 및 (도 4C; AAV5.CR17 캡시드 - 서열번호 103)에 제시한다. hCF 세포에서 15개의 AAV5 변이체(도 4A)의 형질도입 효율을, 비변형 AAV5(가장 우측 바)에 대해 벤치마킹했다. 보다 어두운 바는 이 실험에서 hCF 세포의 형질도입 효율을 증가시킨 서열을 나타낸다.
iPS-CM 세포(도 5A-5D)에서, 형질도입 빈도의 증가도 또한 관찰되었고, 실제로 모 AAV5와 비교하여 형질도입의 배수 증강은 hCF 세포(도 5A 및 도 5D)에서보다 더욱 컸다. 변형되지 않은 AAV5(도 5B) 또는 AAV5.CR23(도 5C)에 의해 형질도입된 hCF에 대한 대표적 형광 이미지가 제시되어 있다.
이어서, 인간 심장 섬유아세포를 사용한 시험을, 마우스 심장 섬유아세포(mCF) 세포에서, AAV5.CAG-GFP 또는 AAV5.CR17.CAG-GFP 중 어느 하나를 사용하여 높은(100,000), 중간(10,000), 또는 낮은(1,000) MOI에서 반복했다. AAV5.CR17 대 AAV5 시험에서 GFP+ 세포의 총 수의 증가에 더하여, 고강도 GFP 집단이 AAV5.CR17에 의해 형성되지만, AAV5에 의해 형성되지 않는 것으로 관찰되었다(도 6A). 따라서, 도 6B-6E에서 각 세포에 대한 강도 측정치는 총 집단 및 고-GFP+ 집단의 세포 서브세트로 게이팅되었다. 높은, 중간 또는 낮은 MOI에서 비변형 AAV5와 비교하여, 세포에 AAV5.CR17을 형질도입한 경우, "총 GFP" 집단에서 증가된 퍼센트 GFP+(도 6B) 및 GFP 강도(도 6C)가 관찰되었다. 세포가 비변형 AAV5와 비교하여 AAV5.CF17로 형질도입된 경우, 증가된 퍼센트 GFP+(도 6D) 및 GFP 강도(도 6E)가 또한 "높은 GFP" 집단에서 관찰되었다. 도 6E의 경향은, 높은 GFP+ 세포를 게이팅하면, 고강도 GFP 발현을 갖는 세포 집단이 선택되었다는 이유만으로 그다지 현저하지 않았다.
생체내 시험
이어서, AAV5.CR17 캡시드를 건강 및 질환 동물에서 생체내 시험했다. 구체적으로, Charles River®(야생형 백그라운드)로부터 공급된 CD-1® IGS 마우스는 건강 및 질병 그룹으로 분리했다. 이환 그룹은 문헌[참조: Gao et al. Circulation Research (2010) 107:1445-1453]의 결찰 방법을 사용하여 유도 심근 경색증(MI)을 받았다. 1.2×1011vg의 AAV5.CAG-GFP 또는 AAV5.CR17.CAG-GFP 중 어느 하나를 심근내 주사를 통해 6주령 CD-1 마우스에 주사했다. GFP 강도 및 분포는 주사 7일 후에 평가되었다. 모든 심장 조직 섹션은 동일한 획득 및 노출로 20× 대물렌즈를 사용하여 이미지화되었다. 항-GFP 면역염색 및 DAPI를 사용한 핵 대비염색이 제시된다. 심근세포 및 섬유아세포는 형태에 의해 구별되었다. 심근세포 및 섬유아세포의 형질도입 증가는, AAV5(도 7A-7B 및 도 7C-7D)와 비교하여, 비-MI 및 MI 동물(도 7E-7F 및 도 7G-7H) 둘 다에서 AAV5.CR17로 관찰된다.
공유 서열 모티프
선택 후에 농후화를 입증하는 삽입 사이에서 공유되는 잔기를 확인하기 위해, 모든 서열 데이터, 또는 라운드 3 후의 최상위 서열을 사용하여 서열 모티프를 생성했다. 간단히 말해서, 서열 모티프는, 표 2의 상위 100개(도 8A), 상위 50개(도 8B), 상위 20개(도 8C) 서열, 게다가 이 실시예에서 시험관내 재시험된 서열(도 8D)에 대해 생성했다. 모티프 내의 각 아미노산의 중요성을 가중하기 위해 각 서열에 대한 판독 수를 사용하여, 모든 서열에 대해 서열 모티프도 생성했다(도 8E). 서열 모티프는 특정 아미노산이 삽입 부위의 특정 위치로서 선호된다는 것을 시사한다.
라이브러리로부터의 상위 서열은 하기 표 2에 제시되어 있다. 삽입의 개시 및 말단에서 인접하는 'A' 잔기는, 일부 실시양태에서, 유연한 아미노산(G 또는 S) 등의 다른 아미노산으로 치환되거나, 부재한다.
삽입 서열의 순서 목록 - hCF 라운드 3 후의 상위 500
서열번호 삽입 모 hCF
라운드 1		 hCF
라운드 2		 HCF
라운드 3		 근세포
라운드 1		 근세포
라운드 3
101 ARKVHIEVA 6 50 2681 11706 993 4433
102 ARKYQSDLA 12 68 1368 3457 540 1181
103 APLTNTVKA 4 43 1498 2382 555 1131
104 ALKYHGPPA 4 16 639 2151 286 818
116 ARKIHLDAA 0 4 376 2004 158 1852
105 ARKYQGDMA 2 19 748 1851 346 1895
106 ARKFHSTDA 1 5 417 1803 179 1416
107 ARKHHGLEA 2 35 807 1523 316 679
108 APGTNVTKA 11 67 1256 1327 475 614
109 ARKMHMPDA 0 18 331 1295 160 406
117 APYHNATKA 6 72 1115 1177 417 258
118 ARKWHDTEA 1 14 398 1045 173 294
119 APVANVTKA 4 28 930 995 374 310
120 ARKVHIGVA 1 6 196 931 76 741
121 APLNNSVKA 8 47 755 927 244 547
122 ARRYHGSEA 0 4 217 901 87 443
123 AYGHPNVIA 11 114 981 757 425 288
124 APFTNSTKA 1 18 450 727 162 359
110 APLKKIVQA 4 32 393 682 178 51
125 ARKVQVGVA 2 13 182 602 62 319
126 AGRCILRVA 0 1 118 591 63 286
127 AKIKTGVPA 8 57 642 554 282 124
128 AWHNSYPHA 0 18 331 531 133 278
111 APLGKKTSA 1 10 165 504 55 15
129 APSVNLTKA 7 39 506 485 193 190
112 APRGVKVTA 0 10 190 479 68 32
130 APLSNLVKA 3 18 323 475 134 184
131 ARKFHTETA 0 2 90 455 42 213
132 AGRFILDAA 0 1 81 439 30 457
133 AVKQNQTKA 9 29 251 426 129 466
134 AVRSNKVAA 10 61 424 415 184 443
135 AGRCILRWA 1 2 90 412 32 116
136 ARKWQQSEA 3 1 145 407 57 164
137 APLKNGTKA 1 10 109 403 45 136
138 AGLKNAVKA 0 12 131 398 60 262
139 APAINHVKA 2 20 414 349 171 112
140 AGVLSNRIA 9 54 450 348 170 173
141 APLANTAKA 3 12 328 341 138 113
142 ARRWHGDEA 1 12 148 332 75 137
143 APLRNANKA 3 28 267 329 106 87
144 APLTNLIKA 6 22 313 329 125 130
145 ARKLQVGSA 5 10 137 327 47 160
146 AEGAYIEVA 0 0 79 320 53 85
147 APMANLVKA 1 15 254 317 120 130
113 APLAKSKSA 1 16 198 312 77 17
114 APRTKGAVA 1 7 216 311 88 22
148 AKTVNATKA 4 8 154 310 68 278
149 APVTKKASA 0 5 153 301 56 19
150 APMPNSAKA 3 13 314 290 96 152
151 AGSIQSDLA 1 2 101 275 31 122
152 ALLRNTVKA 1 12 167 271 73 242
153 AGHLSNHIA 4 25 274 263 140 107
154 APMSNRATA 1 28 305 258 120 91
155 ARKYQLDLA 1 5 107 250 40 300
115 APSGRKATA 1 4 89 247 31 5
156 APHSNSSKA 2 11 186 240 78 113
157 AGLGNAVKA 4 33 339 236 150 137
158 AGSIRGDMA 0 1 90 232 28 267
159 ALLRIRLKA 0 8 176 224 55 196
160 ARKVYIEVA 0 2 69 224 56 59
161 AWKVHIEVA 0 2 64 220 46 66
162 APRSAKPVA 2 12 163 219 72 24
163 APLANLTKA 1 5 174 217 67 58
164 APRGSAVKA 1 27 147 214 41 16
165 AGRLHIEVA 0 2 84 213 34 110
166 APLRISTKA 0 2 123 202 72 82
167 ARKWQSHEA 2 2 92 198 37 67
168 APKVHIEVA 0 0 32 192 29 42
169 ARRCILRWA 0 1 55 189 23 40
170 AKTKSGINA 4 18 126 186 66 65
171 APSINSVKA 1 11 185 184 89 108
172 APSLNLVKA 6 30 246 175 89 53
173 APLGNMTKA 0 6 122 171 47 61
174 ALYHNATKA 0 13 150 163 99 23
175 ALLSNLVKA 2 6 144 162 80 38
176 ALRHKSNNA 0 9 41 154 26 28
177 APRKSNASA 1 21 147 151 68 24
178 APFSNSSKA 1 5 105 150 46 81
179 AGRCILGVA 1 2 47 150 21 170
180 APASNSSRA 2 22 147 149 61 72
181 AGKYQSDLA 0 2 62 146 43 57
182 AGRCILEVA 0 3 32 145 19 79
183 ALTQNSTKA 5 16 183 143 69 171
184 ALIANATKA 0 12 133 143 45 74
185 ARKFHAMEA 2 4 86 141 39 195
186 APLRSTVKA 1 11 53 139 19 5
187 ARYSPNSVA 0 15 166 137 77 64
188 AGKVHIEVA 0 1 38 137 14 49
189 AGSISPDLA 0 3 52 135 21 69
190 ARKVHIEAA 0 0 34 135 32 37
191 ALRMNSVKA 0 10 79 134 46 133
192 APAHKVKAA 3 12 71 132 27 10
193 ACKHHGLEA 1 5 78 132 38 46
194 AGLSNATKA 6 30 232 131 109 121
195 APLANRTSA 5 23 215 131 86 46
196 AGRCILRCA 0 2 28 129 23 96
197 AQEDSFDAA 0 0 32 129 9 42
198 AVSIMGLEA 1 4 87 127 39 82
199 APGTNLIKA 4 7 128 126 54 60
200 ATSGNSVRA 15 53 216 124 126 146
201 ARFPVGSLA 2 11 130 124 60 74
202 APRVTKAAA 0 9 122 124 54 5
203 AGSFHSTDA 0 1 29 124 6 83
204 AHKALVHGA 3 15 131 122 56 313
205 ALLTNTVKA 0 3 92 122 33 30
206 ALLKKIVQA 0 1 88 122 48 5
207 APRDNRTSA 4 20 167 121 58 57
208 APRVNKTVA 0 20 97 121 55 19
209 AGIMSNKIA 2 5 153 121 74 68
210 ALFTNTVKA 0 4 84 119 34 39
211 APRTNITKA 1 10 60 118 20 56
212 AGSFASTDA 0 1 26 118 18 128
213 APQSNVTKA 1 12 143 116 51 38
214 AWRYHGSEA 0 0 27 116 8 28
215 APHKATKSA 1 6 71 114 31 4
216 APLTNTAKA 1 2 72 114 23 33
217 APLGNTAKA 0 4 89 111 39 39
218 APLDNRLKA 1 10 109 110 41 30
219 AGRCILSAA 0 0 37 110 2 26
220 APLINVVKA 0 7 65 109 27 57
221 AGRCILKLA 0 0 32 108 20 58
222 APISGKNKA 0 3 41 105 16 5
223 AKSKAGQVA 6 13 113 102 31 35
224 AGKIHLDAA 0 0 15 102 20 90
225 AGHTNSVKA 1 8 100 101 54 92
226 ALFTNSTKA 1 1 59 98 24 38
227 APSTNTVKA 0 1 56 98 23 17
228 ARKIHLMRA 0 0 26 98 7 41
229 APAPNSVKA 2 9 157 96 54 87
230 AGITGNKIA 0 7 111 95 55 57
231 AGRVHIEVA 0 1 33 93 14 30
232 ARKVHIEGA 0 1 28 93 8 25
233 AKKLNNSIA 0 20 106 92 60 19
234 AGSISRILA 0 0 31 91 12 23
235 AGYMGNHIA 1 15 128 90 53 24
236 AVSIMGWEA 0 0 34 90 12 27
237 AVVSNAARA 7 17 137 89 52 75
238 APRAKVVQA 1 9 109 89 38 3
239 APLGNTVRA 2 11 76 88 31 35
240 APRTTTVKA 0 8 41 88 15 5
241 APGTDVTKA 0 4 78 88 35 93
242 ALGRNVTKA 3 9 68 87 31 65
243 ALKHHGPPA 0 0 21 86 9 23
244 APLRIPTKA 0 0 63 86 20 16
245 AQATNTVRA 8 39 148 85 59 72
246 ASTGNSTRA 4 34 124 85 60 103
247 APMHNGIKA 3 13 75 85 32 48
248 ARKVHTEVA 0 0 28 85 8 23
249 AMKYHGPAA 6 9 66 84 27 30
250 ALHLNSIKA 17 25 146 83 75 57
251 APSINTIKA 1 12 138 83 61 45
252 AGRCILSVA 0 0 12 83 4 12
253 AKAKAGVAA 0 11 72 82 28 26
254 APSSNAAKA 3 6 105 82 33 20
255 ARKVQSGVA 0 4 31 82 14 25
256 AGKYQGDMA 0 1 19 82 22 87
257 AMVIPNVIA 2 16 125 81 35 54
258 AGVKHNSIA 0 8 76 81 29 38
259 ARKHQSDLA 0 2 35 81 19 28
260 AKQPNAVKA 3 1 66 81 33 45
261 AFTHPNSVA 3 11 100 80 53 58
262 APRTSTVKA 1 3 29 79 10 2
263 ARVGVKVTA 0 1 37 79 20 5
264 AEGVHIEVA 0 0 29 79 12 22
265 ASKVHIEVA 0 0 21 79 5 8
266 APLKNAISA 7 39 188 78 65 22
267 ASRNNMTKA 1 12 44 78 29 61
268 ARKVQAGVA 0 0 22 78 8 19
269 AGFTNNTKA 4 18 132 76 61 23
270 APRKVTQSA 1 16 94 76 40 10
271 APLKKGAVA 0 8 63 76 27 5
272 APGKSTAKA 2 3 43 76 18 3
273 AGRCILGCA 0 2 10 76 14 54
274 ALNINSTKA 2 9 109 75 50 65
275 APLGNGAKA 1 7 90 75 39 18
276 AGNHPNKVA 1 4 95 75 54 55
277 AKNVHPNSA 1 13 107 74 55 57
278 APLKAKTSA 0 7 73 74 20 4
279 APLQNSVKA 1 2 57 74 20 28
280 AKYKQGVSA 1 2 68 74 22 17
281 AGSGMILEA 0 1 36 74 20 11
282 ARKVHVPVA 2 16 54 73 18 42
283 ARKIQTMSA 3 15 37 73 19 30
284 ALRGNKIQA 0 8 58 73 27 50
285 APIANNTRA 2 8 75 73 32 26
286 AFHHPNAVA 0 6 76 73 34 33
287 ALKVHIEVA 0 1 15 73 9 22
288 APRGVKTTA 0 5 23 72 12 2
289 AGSFMSTDA 0 0 11 72 6 108
290 AKQIHPNSA 3 27 148 71 68 47
291 ARWRNVTKA 0 2 89 71 15 53
292 ARKYRGDMA 0 1 33 71 25 110
293 APLHNRNNA 1 13 103 70 41 19
294 APHSNRTVA 5 18 120 69 55 30
295 AGIRNVVKA 1 14 43 69 26 62
296 ARSSKPNSA 3 13 59 69 32 21
297 ARTKNGVPA 3 12 67 69 33 22
298 ARYHANSIA 0 9 65 69 23 30
299 AVRTNAVKA 0 6 37 69 14 127
300 AIVSNHSKA 8 18 104 68 45 51
301 APFDNHIRA 0 13 92 68 42 19
302 APRKPNASA 0 7 65 68 15 6
303 ARKVHIGGA 0 0 14 68 11 34
304 AKRASGPTA 2 12 88 67 44 10
305 AECESYFKA 1 2 84 67 26 23
306 APPGRKSSA 1 1 24 67 4 2
307 ARKYQGDIA 0 0 35 67 23 107
308 APITNRSTA 5 21 109 66 54 21
309 APRSVGKAA 0 12 68 66 29 12
310 ACKMHMPDA 0 2 13 66 18 18
311 APLNKKVAA 0 1 25 66 13 2
312 APIANKVSA 3 18 88 65 25 31
313 APRSGVTKA 0 10 41 65 11 5
314 AIRHPNVVA 0 9 115 65 67 42
315 APYQNIVKA 2 7 73 65 24 14
316 AFTANSTKA 0 2 53 65 22 44
317 ARKHQGDMA 0 1 34 65 9 39
318 APLRILLKA 0 1 42 65 17 32
319 AEGAHIEVA 0 0 20 65 20 30
320 AGYSNSVKA 9 23 138 64 60 80
321 APLTNRISA 1 12 83 64 35 19
322 APPHAKKNA 0 1 24 64 6 3
323 AGSFLSTDA 0 0 15 64 2 97
324 ARKYQFDLA 0 0 38 64 10 22
325 ARLRNTAKA 0 4 65 63 23 43
326 ARKMHMLDA 0 0 20 63 8 6
327 APVLNSAKA 2 14 100 62 45 14
328 AGISRNSVA 0 9 61 62 21 21
329 ARSNNTIKA 1 7 73 61 24 32
330 AGVLRNSIA 2 6 73 61 45 28
331 ALLRNSTKA 0 5 58 61 20 69
332 AQIHPNSVA 1 5 79 61 43 24
333 AYIHNSTKA 3 13 85 60 46 55
334 ALLRILLKA 0 2 43 60 12 41
335 APRKNNNSA 1 18 83 59 21 12
336 AGIVANAIA 6 17 123 59 60 13
337 APRKNTVNA 1 7 66 59 25 9
338 ALLRISTKA 0 2 44 59 22 18
339 APGSRKAAA 0 2 32 59 9 1
340 APKAKGGGA 0 23 74 58 31 6
341 APARQKSGA 3 12 62 58 21 9
342 AKSKLGVVA 5 8 84 58 22 15
343 APRGTGKAA 1 8 27 58 12 3
344 APVADVTKA 1 5 83 58 47 60
345 AKITNASKA 0 5 43 58 12 52
346 APRKQTTSA 0 4 26 58 9 4
347 ALLRNANKA 0 3 49 58 36 10
348 ARKYPVSLA 0 1 20 58 8 34
349 APRGNEVKA 0 4 32 57 13 8
350 AWDECVTKA 0 2 48 57 37 12
351 ARKWQQFEA 0 1 13 57 9 8
352 ASLTNTVKA 0 0 39 57 14 29
353 AGLANAVRA 5 27 118 56 31 44
354 ARSGNKVNA 3 11 71 56 30 30
355 APRNNSSKA 1 2 28 56 6 17
356 AFSHPNMIA 2 10 64 55 23 28
357 APMTNKVSA 1 5 79 55 36 18
358 AGSFQVGSA 0 3 28 54 8 37
359 ALYEFYFKA 0 1 46 54 15 14
360 APRASGSKA 2 1 32 54 16 5
361 AGRFIWMRA 0 0 11 54 8 49
362 ALGSNSVRA 7 45 82 53 44 59
363 AGSFIVLDA 0 1 12 53 8 21
364 APGHKAAKA 0 0 20 53 7 6
365 APIKAVKTA 2 12 46 52 15 7
366 APMSNRAAA 0 8 58 52 21 33
367 APLMNKVVA 0 8 86 52 59 16
368 ARYMGNSIA 2 7 78 52 33 11
369 APRVAKPLA 1 7 42 52 17 5
370 ARLGNASKA 1 6 33 52 17 34
371 ARKVRVGVA 0 0 18 52 7 35
372 ASMNNSTKA 5 16 100 51 49 33
373 ALVRNDTRA 5 13 59 51 21 50
374 APAMNITKA 2 7 65 51 26 24
375 APLNKKLSA 1 4 38 51 11 3
376 APYRQCYEA 1 3 41 51 12 16
377 APKLATTKA 0 3 25 51 12 4
378 APAWVKVTA 0 2 12 51 9 1
379 APLTNAVKA 0 0 12 51 15 44
380 AGRLHIGVA 0 0 19 51 9 41
381 AGVIMGREA 0 0 13 51 5 22
382 APLPNSIKA 1 0 49 51 26 18
383 APSGKKTSA 0 0 11 51 10 0
384 APRVSGAKA 1 5 32 50 6 1
385 ARVDNKVKA 0 4 21 50 11 27
386 ARKVHIRVA 0 1 17 50 8 33
387 AGSIQGDMA 1 0 22 50 13 88
388 AGKFHSTDA 0 0 14 50 14 46
389 AGSISRICA 0 0 15 50 8 13
390 AGISSNKTA 4 14 69 49 24 14
391 APHVNTVRA 1 13 64 49 24 27
392 ALRNKAAQA 0 5 38 49 18 10
393 APRLNEVKA 2 4 64 49 22 17
394 AGVHMNSIA 0 4 54 49 36 16
395 APFTDSTKA 0 1 20 49 4 59
396 AARYHGSEA 0 1 10 49 3 14
397 APAGNEVKA 2 1 62 49 29 12
398 AKVHIIEVA 0 0 14 49 15 24
399 AGRCMAEVA 0 0 9 49 3 9
400 APLAKSSKA 0 0 22 49 5 1
401 APVSNTTRA 2 13 64 48 27 18
402 AGVVTNHVA 0 11 84 48 37 9
403 AWDEDVTKA 2 6 38 48 25 28
404 ALTANTVKA 1 3 38 48 21 45
405 ALLRDTVKA 0 3 25 48 13 44
406 AQRYHGSEA 0 2 11 48 4 58
407 ARVRRGAVA 0 2 37 48 17 6
408 APLVKTTKA 0 1 18 48 9 2
409 AAKYHGPPA 0 0 13 48 5 27
410 AGIRNNSTA 3 19 100 47 41 37
411 AKTGGKVAA 2 19 78 47 29 10
412 ARFPAGSLA 5 12 99 47 44 9
413 APGGKANKA 0 5 24 47 16 1
414 AYTKKSVAA 3 3 45 47 28 7
415 APGTNVIKA 0 1 54 47 31 13
416 AGSGMILRA 0 1 24 47 6 12
417 APKGTTAKA 0 1 31 47 16 1
418 ARKIHFGCA 0 0 6 47 4 68
419 ALTTNSIRA 6 16 88 46 41 38
420 ARWQIFTKA 0 8 49 46 21 34
421 AGSVNSVKA 3 6 54 46 34 28
422 APSATKNKA 0 1 21 46 3 1
423 ARKVHIECA 0 0 13 46 7 21
424 AAAGNQVKA 26 45 154 45 64 38
425 AMVSNATKA 3 14 122 45 56 46
426 AGIVTNHVA 1 10 80 45 42 16
427 ALSLNATKA 0 7 58 45 17 25
428 APLANTVKA 0 3 25 45 19 48
429 APYRNATKA 0 3 45 45 19 30
430 AGRCILKVA 0 0 16 45 7 18
431 AWSRSPNAA 2 18 90 44 45 39
432 AMASNSVRA 3 15 56 44 29 54
433 AMAQNSVKA 7 14 122 44 51 64
434 AGIQNNHIA 0 14 95 44 43 18
435 APLKLKAAA 1 4 43 44 19 7
436 APYHIATKA 0 3 39 44 20 6
437 ARWRMLLKA 0 0 41 44 22 17
438 APKKSGSPA 0 12 69 43 33 5
439 ARMSNKTSA 0 8 38 43 12 35
440 AGRLTNQIA 2 8 59 43 25 11
441 APRAGKAAA 1 7 59 43 16 6
442 AGTKNMIKA 3 5 49 43 29 21
443 ARKIHLDTA 0 0 10 43 5 47
444 ARMSNESRA 10 19 84 42 41 31
445 AVVSNAAQA 3 10 47 42 10 56
446 APRTVGNKA 0 7 28 42 13 4
447 APSVDLTKA 1 6 48 42 11 39
448 APRKNSAAA 0 6 51 42 16 16
449 APIGNTTRA 0 5 36 42 13 13
450 AKYIPGTLA 1 5 48 42 17 6
451 APRKPGVQA 0 5 44 42 9 3
452 APRKTSATA 0 3 29 42 10 3
453 APFADSTKA 0 2 21 42 14 37
454 APHTKSKSA 0 2 11 42 10 1
455 ARKFRSTDA 0 1 12 42 5 68
456 AGSIRSDLA 0 1 14 42 7 7
457 ASYEDTVKA 1 0 34 42 6 32
458 ALLRIRLRA 0 0 29 42 13 15
459 ARRCILRVA 0 0 11 42 5 11
460 AGTLNAIKA 7 13 78 41 39 24
461 AQRHNDTRA 9 12 101 41 37 40
462 ARKLQSAQA 5 10 44 41 14 20
463 AKVKGTSAA 3 10 53 41 23 10
464 APRSVQKSA 1 9 56 41 31 4
465 APRGNNLKA 0 3 28 41 8 5
466 APYHNVTKA 1 2 50 41 25 8
467 AGRCMARVA 0 1 7 41 6 38
468 ARKWYDTEA 0 0 17 41 9 13
469 ARKFHSIDA 0 0 12 41 5 8
470 AKKIDNRVA 1 7 69 40 28 28
471 AGAHPNSLA 0 3 43 40 28 10
472 APMGRKAAA 0 3 17 40 14 7
473 AGKWHDTEA 0 0 21 40 8 19
474 APFYEFTKA 0 0 31 40 12 14
475 APNRKSATA 1 13 72 39 24 4
476 APSGNSSRA 2 10 39 39 13 10
477 AAQGNTVRA 2 9 54 39 21 30
478 APRTKSIVA 0 9 59 39 34 6
479 APHLNLAKA 1 8 55 39 16 17
480 APRGAKSSA 0 5 25 39 12 1
481 APKITKPSA 0 3 34 39 13 6
482 ARKYRSDLA 0 2 16 39 14 14
483 ARKYQSSLA 0 0 18 39 10 29
484 ARKWRQSEA 0 0 15 39 5 25
485 AVKMHMPDA 0 0 18 39 4 22
486 AKVGGKAAA 0 10 39 38 10 2
487 APRQVSKTA 1 7 36 38 11 9
488 APATTKVKA 0 5 18 38 7 1
489 ARKIHDGPA 0 3 21 38 5 13
490 AGILRNTIA 3 3 46 38 18 8
491 APSSGKKVA 0 3 33 38 13 1
492 APRSAKPAA 0 3 29 38 18 0
493 ARWRIFTKA 1 2 42 38 24 20
494 AKVNNLTKA 2 2 20 38 17 19
495 APNSNIIKA 0 2 35 38 8 13
496 ARKWHDAEA 0 1 18 38 8 24
497 AGSFHTETA 0 1 11 38 3 11
498 ARKYPVGFA 0 0 19 38 3 25
499 ALRGVKVTA 0 0 23 38 6 1
500 APLGKKISA 0 0 9 38 8 0
501 ARATNEVRA 2 17 74 37 35 38
502 APGGNEVRA 1 13 71 37 30 12
503 ALLGNAVKA 2 8 64 37 25 38
504 APHSNRVSA 1 8 49 37 18 16
505 APRSKNAVA 0 6 62 37 20 5
506 APSINKVKA 0 5 4 37 3 3
507 APAANTVRA 2 4 51 37 22 20
508 ALCRNSAKA 0 3 34 37 9 28
509 APLRSAVKA 1 3 32 37 9 3
510 APLKKHAAA 0 3 18 37 5 2
511 APLTNTVGA 0 1 34 37 12 33
512 ALLIILVKA 0 1 26 37 9 8
513 ALMSNRATA 0 1 38 37 20 7
514 APLVNAVKA 0 0 26 37 12 23
515 APSSKKATA 0 0 12 37 2 0
516 AKFIIGSLA 4 12 83 36 35 6
517 APSTNRVTA 1 7 54 36 17 8
518 APKAPNKSA 0 4 45 36 9 5
519 AKVKLGAAA 3 3 26 36 9 12
520 AEVSVPDLA 0 1 12 36 7 15
521 AGSFIGTDA 0 0 10 36 0 35
522 AEVSYSTDA 0 0 8 36 4 19
523 AGRCIAEVA 0 0 14 36 7 7
524 ARKYQSDFA 0 0 21 36 6 7
525 AALGNVVRA 9 19 75 35 37 40
526 AVASNVVKA 2 14 70 35 29 31
527 ALAGNAVKA 5 14 59 35 29 23
528 APASNVARA 2 12 49 35 22 14
529 AYGHPIVIA 3 3 61 35 21 11
530 ALWLNLVKA 0 2 38 35 9 25
531 ALSVNLTKA 2 2 78 35 54 19
532 APLRNSTKA 0 2 11 35 5 18
533 ALYHPNKVA 0 2 33 35 19 17
534 ARRYQSDLA 0 1 10 35 3 21
535 AAKAMKLGA 0 13 46 34 20 12
536 AAMGNASRA 2 8 51 34 34 44
537 APRALKITA 0 5 47 34 18 5
538 ALSLNLVKA 3 5 52 34 31 2
539 ALVANVTKA 0 4 50 34 30 11
540 AKFVPGTLA 2 3 65 34 33 14
541 ASIHPNAIA 1 3 42 34 23 9
542 AKMKVGVSA 0 3 26 34 10 4
543 APVGAKKGA 0 2 19 34 6 0
544 ASYEYTVKA 0 1 17 34 12 14
545 AQEVSVDLA 0 1 17 34 13 12
546 AGVIMESEA 0 0 8 34 4 29
547 AEGACIEVA 0 0 7 34 8 16
548 AVLFRNIPA 2 10 41 33 15 107
549 APKRSNATA 0 6 34 33 18 4
550 ALRQNLVKA 1 5 41 33 16 26
551 ALRINNVKA 3 4 30 33 7 16
552 APRKAGTVA 1 4 26 33 15 7
553 AQRLNNTKA 0 3 13 33 9 28
554 APLADLTKA 0 2 25 33 4 32
555 APLADTVKA 0 1 15 33 13 38
556 AGRCAIEVA 0 1 10 33 3 17
557 ARKYQPDLA 0 1 22 33 7 12
558 ARKIRLDAA 0 0 6 33 2 43
559 ARRCILSAA 0 0 10 33 7 8
560 AEVSSPDLA 0 0 10 33 4 7
561 AGVIMGSEA 0 0 7 33 0 7
562 AVKYQSDLA 0 0 13 33 8 5
563 APRQAKVAA 1 0 17 33 12 0
564 AQMTNQVKA 7 13 106 32 45 36
565 AGQSNQTRA 2 13 71 32 34 12
566 APVRAATKA 1 13 38 32 10 2
567 AKTKSANSA 0 8 33 32 15 25
568 AFSAHPNKA 0 7 59 32 19 14
569 ARIKGGVPA 0 7 51 32 10 10
570 APWFRDNAA 0 6 35 32 20 2
571 APSKGKSNA 0 5 35 32 9 1
572 APRTNNTVA 0 4 39 32 11 12
573 APKTSKSSA 0 4 48 32 18 5
574 ARKYQAASA 1 3 17 32 3 19
575 APKANLAKA 1 3 32 32 10 6
576 AGVIMGPEA 0 1 12 32 5 34
577 ASYGIRLKA 0 1 16 32 5 28
578 APRTGATKA 0 1 20 32 6 2
579 AARGVKVTA 0 1 6 32 5 2
580 AGSIRSDMA 0 0 12 32 11 39
581 ARIVILVKA 0 0 36 32 11 16
582 ALLRIPTKA 0 0 25 32 8 7
583 AAWGVKVTA 0 0 13 32 6 3
584 APTKKTAVA 0 13 48 31 13 1
585 AIMLNQVKA 5 11 86 31 37 20
586 APGLNYVKA 2 11 53 31 21 13
587 ARKLHSGPA 0 7 20 31 11 23
588 AKWKSGASA 1 5 28 31 12 11
589 AWKAQKTSA 1 5 11 31 9 8
590 APRTKGTAA 0 4 56 31 23 3
591 APRHSKVTA 0 3 43 31 14 2
592 AGTANVTKA 1 2 38 31 24 30
593 ALLGNMTKA 0 2 27 31 14 6
594 ARKVHIEIA 0 1 2 31 1 18
595 AEVSCGPPA 0 1 7 31 8 10
596 AKAKAGVTA 0 1 21 31 11 8
597 ALILNATKA 0 0 26 31 5 15
598 ARSVNLTKA 0 0 41 31 16 9
599 ASYEYGAKA 0 0 27 31 4 9
600 ALKYRGPPA 0 0 10 31 1 9
실시예 2: 형질도입 효율이 증가된 AAV5 캡시드 단백질의 이론적 근거 설계
실시예 1에 기재된 라이브러리 기반 접근방식과 함께, 합리적 설계 접근방식을 사용하여, 형질도입 효율의 증가를 부여하는 AAV5 캡시드 단백질을 동정했다. 표면 노출된 잔류물을 선택했다. 이들 아미노산의 치환은, 실시예 1에 기재된 바와 같이 hCF 검정에서 시험했다. AAV5 캡시드에서 치환 S651A, T578A 또는 T582A는, 감염 72시간 후, 100,000 vg/세포의 감염 다중도에서 개선된 인간 심장 섬유아세포 형질도입을 초래했다(도 9).
후속 실험에서, 이 합리적 설계 실험에서 확인된 치환은, 서로 조합하여, 및 표 1 및 2에 개시되어 있는 삽입과 조합하여 시험한다.
실시예 3: AAVx1 대 야생형 AAV5의 비교 시험
S651A, T578A 및/또는 T582A 치환(AAVx1) 중 2개 또는 3개를 갖는 AAV5 캡시드가 생성되었다. 캡시드 서열은 다음과 같았다:
MSFVDHPPDWLEEVGEGLREFLGLEAGPPKPKPNQQHQDQARGLVLPGYNYLGPGNGLDRGEPVNRADEVAREHDISYNEQLEAGDNPYLKYNHADAEFQEKLADDTSFGGNLGKAVFQAKKRVLEPFGLVEEGAKTAPTGKRIDDHFPKRKKARTEEDSKPSTSSDAEAGPSGSQQLQIPAQPASSLGADTMSAGGGGPLGDNNQGADGVGNASGDWHCDSTWMGDRVVTKSTRTWVLPSYNNHQYREIKSGSVDGSNANAYFGYSTPWGYFDFNRFHSHWSPRDWQRLINNYWGFRPRSLRVKIFNIQVKEVTVQDSTTTIANNLTSTVQVFTDDDYQLPYVVGNGTEGCLPAFPPQVFTLPQYGYATLNRDNTENPTERSSFFCLEYFPSKMLRTGNNFEFTYNFEEVPFHSSFAPSQNLFKLANPLVDQYLYRFVSTNNTGGVQFNKNLAGRYANTYKNWFPGPMGRTQGWNLGSGVNRASVSAFATTNRMELEGASYQVPPQPNGMTNNLQGSNTYALENTMIFNSQPANPGTTATYLEGNMLITSESETQPVNRVAYNVGGQMATNNQSST X APA X GTYNLQEIVPGSVWMERDVYLQGPIWAKIPETGAHFHPSPAMGGFGLKHPPPMMLIKNTPVPGNITSF X DVPVSSFITQYSTGQVTVEMEWELKKENSKRWNPEIQYTNNYNDPQFVDFAPDSTGEYRTTRPIGTRYLTRPL, 여기서 X = A, G, V, S, 또는 T (서열번호 73)
인간 심장 섬유아세포(hCF)를 형질도입하는 능력을 시험하기 위해, hCF를 1,000 내지 1,000,000 범위의 MOI에서 AAV5.CAG-GFP 또는 AAVx1(T582A + S651A)로 감염시켰다. 감염 48시간 후, 세포를 회수하고, 유세포 분석을 사용하여 GFP 발현을 정량화했다. 시험된 모든 MOI에서, 퍼센트 형질도입(도 10A), GFP 발현(도 10B), 및 상대적 형질도입(도 10C)은 야생형 AAV5 캡시드와 비교하여 증가했다.
기능적 카고(cargo)를 전달하는 AAVx1 벡터의 능력은, 미오카르딘 및 ASCL1(MyA)을 암호화하는 발현 카세트를 포함하는 AAV5 및 AAVx1 벡터를 생성함으로써 시험되었다. 국제 특허출원 제PCT/US2019/049150호 및 미국 가특허 출원 제62/788,479호(각각은 참조에 의해 본원에 도입됨)에 기재된 마이코카르딘 MyΔ3의 내부 결실이 사용되었다. 놀랍게도, AAVx1 벡터는, 감염후 7일차의 도입유전자 및 마커 발현에 기초하여, AAV5 벡터보다 평균 9배 더 우수한 성능을 나타냈다(표 3에 제시됨).
　 MYOCD ASCL1 ACTC1 CASQ2 NPPA PLN TNNT2
NO INF. 0.9 0.7 1.1 1.3 1.3 1.0 1.1
1.1 1.5 0.9 0.9 1.4 1.1 1.0
AAV5: MY△3A+ MOI 400K 111.3 772.4 12.5 27.9 779.2 20.0 129.0
117.0 772.2 11.8 29.5 512.2 18.0 120.0
AAV5: MY△3A+ MOI 1.2M 219.0 1345.2 17.4 40.6 756.9 35.5 200.9
176.2 1230.6 17.1 44.9 922.6 30.5 171.6
AAVx1: MY△3A+ MOI 400K 897.5 5743.7 119.6 321.9 6165.3 143.5 1010.5
811.0 5619.1 103.8 288.4 5875.2 127.9 972.3
AAVx1: MY△3A+ MOI 1.2M 1680.1 11924.0 188.8 587.3 10753.4 234.1 2013.0
1683.6 11225.0 196.2 490.3 10787.2 246.7 1795.3
실시예 4: AAVx1에 의한 심장 조직의 생체내 형질도입
마우스에서의 시험
생체내 형질도입을 평가하기 위해, AAV5 또는 AAVx1(T582A + S651A) 캡시드를 사용하여, 심근경색증(MI)의 LAD-결찰 마우스 모델을 사용하고, 손상시에 심외막에 AAV 벡터를 주입하여, 마우스에서 GFP 리포터를 암호화하는 발현 카세트를 전달했다. 1.2×1011 게놈 카피(GC)의 단일 벡터 용량이, 심장내 주사에 의해 각 대상체의 심장에 전달되었다. 주사 7일 후, 동물을 희생시키고, 효소 소화에 의해 심장을 해리시켰다. 해리된 세포를 내피 마커(CD31) 및 섬유아세포 마커(Thy-1)로 염색하고, 형광 활성화 세포 분류(FAC)를 사용하여 분류했다. GFP+, Thy-1+ 및 CD31- 세포는, 형질도입된 심장 섬유아세포로서 분류되었고, GFP-, Thy-1+ 및 CD31- 세포는, 형질도입되지 않은 심장 섬유아세포로서 분류되었다. 형질도입된 세포의 수를 AAV5로 정규화했다. 도 11에 도시된 바와 같이, 심장 섬유아세포(CF)의 생체내 형질도입은 AAV5 벡터보다도 AAVx1 벡터를 사용한 경우에 4배 이상 더 컸다.
기능적 생체내 시험을 위해, AAVx1(T582A + S651A) 캡시드를 사용하여, 미오카르딘 및 ASCL1(MyA)을 암호화하는 발현 카세트를 전달했다. AAVx1 벡터는, 심근경색증(MI)의 LAD-결찰 마우스 모델을 사용하여 마우스에서 시험되었고, AAV 벡터의 주사는 손상시에 심외막에서 수행되었다. 1.2×1011 게놈 카피(GC)의 단일 벡터 용량이 심장내 주사에 의해 각 대상체의 심장에 전달되었다.
효능은, 주사후 2, 4, 6 및 8주에서 심장초음파검사에 의해 평가했다. AAVx1 벡터는, GFP-암호화 대조군과 비교하여, 심장 기능(구출률)을 유의하게 보존했다(도 12).
돼지에서의 시험
AAVx1 벡터는, 돼지 심근경색증(MI) 모델에서 추가로 시험되었다. MyA는 AAVx1 캡시드로 패키징되었고, 허혈성 손상을 도입하기 위해 90분의 볼룬 폐색(balloon occlusion) 28일 후에 돼지 심장의 경계 영역에 심외막으로 주입되었다. 병행하여, 경색된 돼지에도 제제 완충액을 주사하여, 각 그룹은 10마리의 동물로 구성되도록 했다. 심장초음파는 주사 후 3주, 5주, 7주 및 9주에 실시되었다. AAVx1 벡터를 투여받은 돼지는, 주사 후 5주, 7주 및 9주의 대조군과 비교하여, 구출률의 유의한 개선을 나타냈다(도 13). 따라서, AAVx1 벡터에 의한 치료는 투여 전 기준선을 초과하는 심장 성능에서 평균 10%의 개선을 초래했다.
SEQUENCE LISTING <110> Tenaya Therapeutics Inc. Reid, Christopher A. <120> ADENO-ASSOCIATED VIRUS WITH ENGINEERED CAPSID <130> TENA-012/02WO 334682-2079 <150> US 62/984,197 <151> 2020-03-02 <150> US 62/827,576 <151> 2019-04-01 <160> 1107 <170> PatentIn version 3.5 <210> 1 <211> 724 <212> PRT <213> Dependoparvovirus adeno associated virus 5 <400> 1 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 2 <211> 350 <212> PRT <213> Dependoparvovirus adeno associated virus 5 <400> 2 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 210 215 220 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 225 230 235 240 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 245 250 255 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 260 265 270 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 275 280 285 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 290 295 300 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 305 310 315 320 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 325 330 335 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln 340 345 350 <210> 3 <211> 150 <212> PRT <213> Dependoparvovirus adeno associated virus 5 <400> 3 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 1 5 10 15 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 20 25 30 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 35 40 45 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 50 55 60 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 65 70 75 80 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 85 90 95 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 100 105 110 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 115 120 125 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 130 135 140 Tyr Leu Thr Arg Pro Leu 145 150 <210> 4 <211> 509 <212> PRT <213> Artificial Sequence <220> <223> Recombinant Dependoparvovirus adeno associated virus 5 Capsid Protein VP3 <220> <221> MISC_FEATURE <222> (351)..(359) <223> Xaa can be any naturally occurring amino acid <400> 4 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 210 215 220 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 225 230 235 240 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 245 250 255 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 260 265 270 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 275 280 285 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 290 295 300 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 305 310 315 320 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 325 330 335 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Xaa Xaa 340 345 350 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ser Thr Thr Ala Pro Ala Thr Gly 355 360 365 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 370 375 380 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 385 390 395 400 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 405 410 415 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 420 425 430 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 435 440 445 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 450 455 460 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 465 470 475 480 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 485 490 495 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 500 505 <210> 5 <211> 509 <212> PRT <213> Artificial Sequence <220> <223> Recombinant Dependoparvovirus adeno associated virus 5 Capsid Protein VP3 <220> <221> MISC_FEATURE <222> (352)..(358) <223> Xaa can be any naturally occurring amino acid <400> 5 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 210 215 220 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 225 230 235 240 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 245 250 255 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 260 265 270 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 275 280 285 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 290 295 300 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 305 310 315 320 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 325 330 335 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Xaa 340 345 350 Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 355 360 365 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 370 375 380 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 385 390 395 400 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 405 410 415 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 420 425 430 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 435 440 445 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 450 455 460 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 465 470 475 480 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 485 490 495 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 500 505 <210> 6 <211> 87 <212> DNA <213> Artificial Sequence <220> <223> Oligonucleotide primer P1 <220> <221> misc_feature <222> (34)..(35) <223> n is a, c, g, or t <220> <221> misc_feature <222> (37)..(38) <223> n is a, c, g, or t <220> <221> misc_feature <222> (40)..(41) <223> n is a, c, g, or t <220> <221> misc_feature <222> (43)..(44) <223> n is a, c, g, or t <220> <221> misc_feature <222> (46)..(47) <223> n is a, c, g, or t <220> <221> misc_feature <222> (49)..(50) <223> n is a, c, g, or t <220> <221> misc_feature <222> (52)..(53) <223> n is a, c, g, or t <400> 6 gtcggcgggc agatggccac caacaaccag gccnnknnkn nknnknnknn knnkgccagc 60 tccaccactg cccccgcgac cggcacg 87 <210> 7 <211> 40 <212> DNA <213> Artificial Sequence <220> <223> Oligonucleotide primer P2 <400> 7 tccccagcat gagcgatgca ttttattgag ggtatgcgac 40 <210> 8 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> Oligonucleotide primer P3 <400> 8 ccatcgacgt cagacgcgga agcttcgatc aactacgcag acag 44 <210> 9 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR2 <400> 9 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Arg 565 570 575 Lys Val His Ile Glu Val Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 10 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR5 <400> 10 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Arg 565 570 575 Lys Tyr Gln Ser Asp Leu Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 11 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR8 <400> 11 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Arg 565 570 575 Lys His His Gly Leu Glu Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 12 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR17 <400> 12 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Pro 565 570 575 Leu Thr Asn Thr Val Lys Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 13 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR18 <400> 13 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Leu 565 570 575 Lys Tyr His Gly Pro Pro Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 14 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR19 <400> 14 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Arg 565 570 575 Lys Tyr Gln Gly Asp Met Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 15 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR20 <400> 15 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Arg 565 570 575 Lys Phe His Ser Thr Asp Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 16 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR21 <400> 16 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Pro 565 570 575 Gly Thr Asn Val Thr Lys Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 17 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR22 <400> 17 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Arg 565 570 575 Lys Met His Met Pro Asp Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 18 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR23 <400> 18 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Pro 565 570 575 Leu Lys Lys Ile Val Gln Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 19 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR24 <400> 19 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Pro 565 570 575 Leu Gly Lys Lys Thr Ser Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 20 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR25 <400> 20 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Pro 565 570 575 Arg Gly Val Lys Val Thr Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 21 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR26 <400> 21 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Pro 565 570 575 Leu Ala Lys Ser Lys Ser Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 22 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR27 <400> 22 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Pro 565 570 575 Arg Thr Lys Gly Ala Val Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 23 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR28 <400> 23 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Pro 565 570 575 Ser Gly Arg Lys Ala Thr Ala Ser Ser Thr Thr Ala Pro Ala Thr Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 24 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> AAV5.K251R <400> 24 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Arg Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 25 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> AAV5.S485A <400> 25 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ala Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 26 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> AAV5.S651A <400> 26 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ala Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 27 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> AAV5.T578A <400> 27 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Ala Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 28 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> AAV5.T582A <400> 28 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Thr Ala Pro Ala Ala Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 29 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> AAV5.Y709F <400> 29 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Phe Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 30 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> AAV5.Y693F <400> 30 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Phe Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 31 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR17(444) andT591A <400> 31 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 435 440 445 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 450 455 460 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 465 470 475 480 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 485 490 495 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 500 505 510 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 515 520 525 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 530 535 540 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 545 550 555 560 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 565 570 575 Gln Met Ala Thr Asn Asn Gln Ser Ser Thr Thr Ala Pro Ala Ala Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 32 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR17(575) and T591A <400> 32 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Pro 565 570 575 Leu Thr Asn Thr Val Lys Ala Ser Ser Thr Thr Ala Pro Ala Ala Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ser Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 33 <211> 733 <212> PRT <213> Artificial Sequence <220> <223> AAV5.CR17(575) and T591A and S660A <400> 33 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ala Pro 565 570 575 Leu Thr Asn Thr Val Lys Ala Ser Ser Thr Thr Ala Pro Ala Ala Gly 580 585 590 Thr Tyr Asn Leu Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg 595 600 605 Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly 610 615 620 Ala His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His 625 630 635 640 Pro Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile 645 650 655 Thr Ser Phe Ala Asp Val Pro Val Ser Ser Phe Ile Thr Gln Tyr Ser 660 665 670 Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn 675 680 685 Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asp 690 695 700 Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr Arg Thr 705 710 715 720 Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 725 730 <210> 34 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> AAV5.T582A and S651A <400> 34 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Thr Ala Pro Ala Ala Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ala Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 35 <400> 35 000 <210> 36 <400> 36 000 <210> 37 <400> 37 000 <210> 38 <400> 38 000 <210> 39 <400> 39 000 <210> 40 <400> 40 000 <210> 41 <400> 41 000 <210> 42 <400> 42 000 <210> 43 <400> 43 000 <210> 44 <400> 44 000 <210> 45 <400> 45 000 <210> 46 <400> 46 000 <210> 47 <400> 47 000 <210> 48 <400> 48 000 <210> 49 <400> 49 000 <210> 50 <400> 50 000 <210> 51 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR2 <400> 51 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggcccggaa ggtgcatatt 1740 gaggtggcca gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 52 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR5 <400> 52 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggcgcgaaa gtatcagagt 1740 gatctcgcta gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 53 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR8 <400> 53 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggcacggaa gcatcatggc 1740 cttgaagcga gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 54 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR17 <400> 54 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggcaccgtt gaccaataca 1740 gtaaaggcaa gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 55 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR18 <400> 55 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggcactcaa ataccacgga 1740 cctccagcga gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 56 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR19 <400> 56 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggcaagaaa atatcaagga 1740 gatatggcca gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 57 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR20 <400> 57 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggcgcgcaa gtttcactca 1740 acggatgcga gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 58 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR21 <400> 58 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggcaccggg aaccaacgtg 1740 acgaaggcaa gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 59 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR22 <400> 59 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggcccgtaa gatgcatatg 1740 cctgatgcca gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 60 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR23 <400> 60 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggccccatt gaaaaaaatc 1740 gtccaagcaa gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 61 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR24 <400> 61 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggctcctct tggcaaaaaa 1740 acctcagcaa gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 62 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR25 <400> 62 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggcaccccg aggagtgaag 1740 gtcacggcta gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 63 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR26 <400> 63 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggctcctct tgctaaatct 1740 aagtccgcca gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 64 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR27 <400> 64 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggcgccgcg aactaaaggt 1740 gctgtcgcca gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 65 <211> 2202 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.CR28 <400> 65 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc aggccccaag tggacggaag 1740 gctactgcaa gctccaccac tgcccccgcg accggcacgt acaacctcca ggaaatcgtg 1800 cccggcagcg tgtggatgga gagggacgtg tacctccaag gacccatctg ggccaagatc 1860 ccagagacgg gggcgcactt tcacccctct ccggccatgg gcggattcgg actcaaacac 1920 ccaccgccca tgatgctcat caagaacacg cctgtgcccg gaaatatcac cagcttctcg 1980 gacgtgcccg tcagcagctt catcacccag tacagcaccg ggcaggtcac cgtggagatg 2040 gagtgggagc tcaagaagga aaactccaag aggtggaacc cagagatcca gtacacaaac 2100 aactacaacg acccccagtt tgtggacttt gccccggaca gcaccgggga atacagaacc 2160 accagaccta tcggaacccg ataccttacc cgaccccttt aa 2202 <210> 66 <211> 2175 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.K251R <400> 66 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aggagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc 1740 gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac 1800 gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc 1860 tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac 1920 acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc 1980 cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc 2040 aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac 2100 tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt 2160 acccgacccc tttaa 2175 <210> 67 <211> 2175 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.S485A <400> 67 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccgccgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc 1740 gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac 1800 gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc 1860 tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac 1920 acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc 1980 cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc 2040 aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac 2100 tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt 2160 acccgacccc tttaa 2175 <210> 68 <211> 2175 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.S651A <400> 68 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc 1740 gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac 1800 gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc 1860 tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac 1920 acgcctgtgc ccggaaatat caccagcttc gccgacgtgc ccgtcagcag cttcatcacc 1980 cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc 2040 aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac 2100 tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt 2160 acccgacccc tttaa 2175 <210> 69 <211> 2175 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.T578A <400> 69 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cgccgccccc 1740 gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac 1800 gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc 1860 tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac 1920 acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc 1980 cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc 2040 aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac 2100 tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt 2160 acccgacccc tttaa 2175 <210> 70 <211> 2175 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.T582A <400> 70 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc 1740 gcggccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac 1800 gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc 1860 tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac 1920 acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc 1980 cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc 2040 aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac 2100 tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt 2160 acccgacccc tttaa 2175 <210> 71 <211> 2175 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.Y709F <400> 71 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc 1740 gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac 1800 gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc 1860 tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac 1920 acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc 1980 cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc 2040 aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac 2100 tttgccccgg acagcaccgg ggaattcaga accaccagac ctatcggaac ccgatacctt 2160 acccgacccc tttaa 2175 <210> 72 <211> 2175 <212> DNA <213> Artificial Sequence <220> <223> Recombinant polynucleotide engineered capsid AAV5.Y693F <400> 72 atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag 60 tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa 120 gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga 180 ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag 240 cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag 300 gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc 360 aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc 420 ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc 480 aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc 540 ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca 600 ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc 660 gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc 720 agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc 780 aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc 840 cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg 900 tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc 960 accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag 1020 ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc 1080 tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc 1140 gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac 1200 aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt 1260 cagaacctct tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc 1320 acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc 1380 tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg 1440 gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg 1500 agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc 1560 tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc 1620 acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc 1680 gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc 1740 gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac 1800 gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc 1860 tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac 1920 acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc 1980 cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc 2040 aagaggtgga acccagagat ccagtacaca aacaacttca acgaccccca gtttgtggac 2100 tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt 2160 acccgacccc tttaa 2175 <210> 73 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> mutated AAV5 capsid protein <220> <221> MISC_FEATURE <222> (578)..(578) <223> Xaa is Ala, Gly, Val, Ser or Thr <220> <221> MISC_FEATURE <222> (582)..(582) <223> Xaa is Ala, Gly, Val, Ser or Thr <220> <221> MISC_FEATURE <222> (651)..(651) <223> Xaa is Ala, Gly, Val, Ser or Thr <400> 73 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Xaa Ala Pro Ala Xaa Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Xaa Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 74 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> mutated AAV5 capsid protein <400> 74 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Ala Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 75 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> mutated AAV5 capsid protein <400> 75 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Thr Ala Pro Ala Ala Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 76 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> mutated AAV5 capsid protein <400> 76 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ala Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 77 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> mutated AAV5 capsid protein <400> 77 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Ala Ala Pro Ala Ala Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 78 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> mutated AAV5 capsid protein <400> 78 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Ala Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ala Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 79 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> mutated AAV5 capsid protein <400> 79 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Thr Ala Pro Ala Ala Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ala Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 80 <211> 724 <212> PRT <213> Artificial Sequence <220> <223> mutated AAV5 capsid protein <400> 80 Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 1 5 10 15 Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 20 25 30 Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 35 40 45 Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 50 55 60 Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 65 70 75 80 Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 85 90 95 Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 100 105 110 Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 115 120 125 Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 130 135 140 Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 145 150 155 160 Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 165 170 175 Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 180 185 190 Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 195 200 205 Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 210 215 220 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 225 230 235 240 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 245 250 255 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 260 265 270 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 275 280 285 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 290 295 300 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 305 310 315 320 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 325 330 335 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 340 345 350 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 355 360 365 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 370 375 380 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 385 390 395 400 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 405 410 415 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 420 425 430 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 435 440 445 Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 450 455 460 Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 465 470 475 480 Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 485 490 495 Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 500 505 510 Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 515 520 525 Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 530 535 540 Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 545 550 555 560 Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 565 570 575 Thr Ala Ala Pro Ala Ala Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 580 585 590 Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 595 600 605 Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 610 615 620 Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 625 630 635 640 Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ala Asp Val Pro Val Ser 645 650 655 Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 660 665 670 Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 675 680 685 Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 690 695 700 Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 705 710 715 720 Thr Arg Pro Leu <210> 81 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 81 Arg Lys Val His Ile Glu Val 1 5 <210> 82 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 82 Arg Lys Tyr Gln Ser Asp Leu 1 5 <210> 83 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 83 Pro Leu Thr Asn Thr Val Lys 1 5 <210> 84 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 84 Leu Lys Tyr His Gly Pro Pro 1 5 <210> 85 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 85 Arg Lys Tyr Gln Gly Asp Met 1 5 <210> 86 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 86 Arg Lys Phe His Ser Thr Asp 1 5 <210> 87 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 87 Arg Lys His His Gly Leu Glu 1 5 <210> 88 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 88 Pro Gly Thr Asn Val Thr Lys 1 5 <210> 89 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 89 Arg Lys Met His Met Pro Asp 1 5 <210> 90 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 90 Pro Leu Lys Lys Ile Val Gln 1 5 <210> 91 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 91 Pro Leu Gly Lys Lys Thr Ser 1 5 <210> 92 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 92 Pro Arg Gly Val Lys Val Thr 1 5 <210> 93 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 93 Pro Leu Ala Lys Ser Lys Ser 1 5 <210> 94 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 94 Pro Arg Thr Lys Gly Ala Val 1 5 <210> 95 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 95 Pro Ser Gly Arg Lys Ala Thr 1 5 <210> 96 <400> 96 000 <210> 97 <400> 97 000 <210> 98 <400> 98 000 <210> 99 <400> 99 000 <210> 100 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <220> <221> MISC_FEATURE <222> (2)..(7) <223> Xaa can be any naturally occurring amino acid <400> 100 Ala Xaa Xaa Xaa Xaa Xaa Xaa Ala 1 5 <210> 101 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 101 Ala Arg Lys Val His Ile Glu Val Ala 1 5 <210> 102 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 102 Ala Arg Lys Tyr Gln Ser Asp Leu Ala 1 5 <210> 103 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 103 Ala Pro Leu Thr Asn Thr Val Lys Ala 1 5 <210> 104 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 104 Ala Leu Lys Tyr His Gly Pro Pro Ala 1 5 <210> 105 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 105 Ala Arg Lys Tyr Gln Gly Asp Met Ala 1 5 <210> 106 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 106 Ala Arg Lys Phe His Ser Thr Asp Ala 1 5 <210> 107 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 107 Ala Arg Lys His His Gly Leu Glu Ala 1 5 <210> 108 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 108 Ala Pro Gly Thr Asn Val Thr Lys Ala 1 5 <210> 109 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 109 Ala Arg Lys Met His Met Pro Asp Ala 1 5 <210> 110 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 110 Ala Pro Leu Lys Lys Ile Val Gln Ala 1 5 <210> 111 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 111 Ala Pro Leu Gly Lys Lys Thr Ser Ala 1 5 <210> 112 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 112 Ala Pro Arg Gly Val Lys Val Thr Ala 1 5 <210> 113 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 113 Ala Pro Leu Ala Lys Ser Lys Ser Ala 1 5 <210> 114 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 114 Ala Pro Arg Thr Lys Gly Ala Val Ala 1 5 <210> 115 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 115 Ala Pro Ser Gly Arg Lys Ala Thr Ala 1 5 <210> 116 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 116 Ala Arg Lys Ile His Leu Asp Ala Ala 1 5 <210> 117 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 117 Ala Pro Tyr His Asn Ala Thr Lys Ala 1 5 <210> 118 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 118 Ala Arg Lys Trp His Asp Thr Glu Ala 1 5 <210> 119 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 119 Ala Pro Val Ala Asn Val Thr Lys Ala 1 5 <210> 120 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 120 Ala Arg Lys Val His Ile Gly Val Ala 1 5 <210> 121 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 121 Ala Pro Leu Asn Asn Ser Val Lys Ala 1 5 <210> 122 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 122 Ala Arg Arg Tyr His Gly Ser Glu Ala 1 5 <210> 123 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 123 Ala Tyr Gly His Pro Asn Val Ile Ala 1 5 <210> 124 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 124 Ala Pro Phe Thr Asn Ser Thr Lys Ala 1 5 <210> 125 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 125 Ala Arg Lys Val Gln Val Gly Val Ala 1 5 <210> 126 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 126 Ala Gly Arg Cys Ile Leu Arg Val Ala 1 5 <210> 127 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 127 Ala Lys Ile Lys Thr Gly Val Pro Ala 1 5 <210> 128 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 128 Ala Trp His Asn Ser Tyr Pro His Ala 1 5 <210> 129 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 129 Ala Pro Ser Val Asn Leu Thr Lys Ala 1 5 <210> 130 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 130 Ala Pro Leu Ser Asn Leu Val Lys Ala 1 5 <210> 131 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 131 Ala Arg Lys Phe His Thr Glu Thr Ala 1 5 <210> 132 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 132 Ala Gly Arg Phe Ile Leu Asp Ala Ala 1 5 <210> 133 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 133 Ala Val Lys Gln Asn Gln Thr Lys Ala 1 5 <210> 134 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 134 Ala Val Arg Ser Asn Lys Val Ala Ala 1 5 <210> 135 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 135 Ala Gly Arg Cys Ile Leu Arg Trp Ala 1 5 <210> 136 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 136 Ala Arg Lys Trp Gln Gln Ser Glu Ala 1 5 <210> 137 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 137 Ala Pro Leu Lys Asn Gly Thr Lys Ala 1 5 <210> 138 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 138 Ala Gly Leu Lys Asn Ala Val Lys Ala 1 5 <210> 139 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 139 Ala Pro Ala Ile Asn His Val Lys Ala 1 5 <210> 140 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 140 Ala Gly Val Leu Ser Asn Arg Ile Ala 1 5 <210> 141 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 141 Ala Pro Leu Ala Asn Thr Ala Lys Ala 1 5 <210> 142 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 142 Ala Arg Arg Trp His Gly Asp Glu Ala 1 5 <210> 143 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 143 Ala Pro Leu Arg Asn Ala Asn Lys Ala 1 5 <210> 144 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 144 Ala Pro Leu Thr Asn Leu Ile Lys Ala 1 5 <210> 145 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 145 Ala Arg Lys Leu Gln Val Gly Ser Ala 1 5 <210> 146 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 146 Ala Glu Gly Ala Tyr Ile Glu Val Ala 1 5 <210> 147 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 147 Ala Pro Met Ala Asn Leu Val Lys Ala 1 5 <210> 148 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 148 Ala Lys Thr Val Asn Ala Thr Lys Ala 1 5 <210> 149 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 149 Ala Pro Val Thr Lys Lys Ala Ser Ala 1 5 <210> 150 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 150 Ala Pro Met Pro Asn Ser Ala Lys Ala 1 5 <210> 151 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 151 Ala Gly Ser Ile Gln Ser Asp Leu Ala 1 5 <210> 152 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 152 Ala Leu Leu Arg Asn Thr Val Lys Ala 1 5 <210> 153 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 153 Ala Gly His Leu Ser Asn His Ile Ala 1 5 <210> 154 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 154 Ala Pro Met Ser Asn Arg Ala Thr Ala 1 5 <210> 155 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 155 Ala Arg Lys Tyr Gln Leu Asp Leu Ala 1 5 <210> 156 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 156 Ala Pro His Ser Asn Ser Ser Lys Ala 1 5 <210> 157 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 157 Ala Gly Leu Gly Asn Ala Val Lys Ala 1 5 <210> 158 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 158 Ala Gly Ser Ile Arg Gly Asp Met Ala 1 5 <210> 159 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 159 Ala Leu Leu Arg Ile Arg Leu Lys Ala 1 5 <210> 160 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 160 Ala Arg Lys Val Tyr Ile Glu Val Ala 1 5 <210> 161 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 161 Ala Trp Lys Val His Ile Glu Val Ala 1 5 <210> 162 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 162 Ala Pro Arg Ser Ala Lys Pro Val Ala 1 5 <210> 163 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 163 Ala Pro Leu Ala Asn Leu Thr Lys Ala 1 5 <210> 164 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 164 Ala Pro Arg Gly Ser Ala Val Lys Ala 1 5 <210> 165 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 165 Ala Gly Arg Leu His Ile Glu Val Ala 1 5 <210> 166 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 166 Ala Pro Leu Arg Ile Ser Thr Lys Ala 1 5 <210> 167 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 167 Ala Arg Lys Trp Gln Ser His Glu Ala 1 5 <210> 168 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 168 Ala Pro Lys Val His Ile Glu Val Ala 1 5 <210> 169 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 169 Ala Arg Arg Cys Ile Leu Arg Trp Ala 1 5 <210> 170 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 170 Ala Lys Thr Lys Ser Gly Ile Asn Ala 1 5 <210> 171 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 171 Ala Pro Ser Ile Asn Ser Val Lys Ala 1 5 <210> 172 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 172 Ala Pro Ser Leu Asn Leu Val Lys Ala 1 5 <210> 173 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 173 Ala Pro Leu Gly Asn Met Thr Lys Ala 1 5 <210> 174 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 174 Ala Leu Tyr His Asn Ala Thr Lys Ala 1 5 <210> 175 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 175 Ala Leu Leu Ser Asn Leu Val Lys Ala 1 5 <210> 176 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 176 Ala Leu Arg His Lys Ser Asn Asn Ala 1 5 <210> 177 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 177 Ala Pro Arg Lys Ser Asn Ala Ser Ala 1 5 <210> 178 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 178 Ala Pro Phe Ser Asn Ser Ser Lys Ala 1 5 <210> 179 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 179 Ala Gly Arg Cys Ile Leu Gly Val Ala 1 5 <210> 180 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 180 Ala Pro Ala Ser Asn Ser Ser Arg Ala 1 5 <210> 181 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 181 Ala Gly Lys Tyr Gln Ser Asp Leu Ala 1 5 <210> 182 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 182 Ala Gly Arg Cys Ile Leu Glu Val Ala 1 5 <210> 183 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 183 Ala Leu Thr Gln Asn Ser Thr Lys Ala 1 5 <210> 184 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 184 Ala Leu Ile Ala Asn Ala Thr Lys Ala 1 5 <210> 185 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 185 Ala Arg Lys Phe His Ala Met Glu Ala 1 5 <210> 186 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 186 Ala Pro Leu Arg Ser Thr Val Lys Ala 1 5 <210> 187 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 187 Ala Arg Tyr Ser Pro Asn Ser Val Ala 1 5 <210> 188 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 188 Ala Gly Lys Val His Ile Glu Val Ala 1 5 <210> 189 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 189 Ala Gly Ser Ile Ser Pro Asp Leu Ala 1 5 <210> 190 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 190 Ala Arg Lys Val His Ile Glu Ala Ala 1 5 <210> 191 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 191 Ala Leu Arg Met Asn Ser Val Lys Ala 1 5 <210> 192 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 192 Ala Pro Ala His Lys Val Lys Ala Ala 1 5 <210> 193 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 193 Ala Cys Lys His His Gly Leu Glu Ala 1 5 <210> 194 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 194 Ala Gly Leu Ser Asn Ala Thr Lys Ala 1 5 <210> 195 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 195 Ala Pro Leu Ala Asn Arg Thr Ser Ala 1 5 <210> 196 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 196 Ala Gly Arg Cys Ile Leu Arg Cys Ala 1 5 <210> 197 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 197 Ala Gln Glu Asp Ser Phe Asp Ala Ala 1 5 <210> 198 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 198 Ala Val Ser Ile Met Gly Leu Glu Ala 1 5 <210> 199 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 199 Ala Pro Gly Thr Asn Leu Ile Lys Ala 1 5 <210> 200 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 200 Ala Thr Ser Gly Asn Ser Val Arg Ala 1 5 <210> 201 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 201 Ala Arg Phe Pro Val Gly Ser Leu Ala 1 5 <210> 202 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 202 Ala Pro Arg Val Thr Lys Ala Ala Ala 1 5 <210> 203 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 203 Ala Gly Ser Phe His Ser Thr Asp Ala 1 5 <210> 204 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 204 Ala His Lys Ala Leu Val His Gly Ala 1 5 <210> 205 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 205 Ala Leu Leu Thr Asn Thr Val Lys Ala 1 5 <210> 206 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 206 Ala Leu Leu Lys Lys Ile Val Gln Ala 1 5 <210> 207 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 207 Ala Pro Arg Asp Asn Arg Thr Ser Ala 1 5 <210> 208 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 208 Ala Pro Arg Val Asn Lys Thr Val Ala 1 5 <210> 209 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 209 Ala Gly Ile Met Ser Asn Lys Ile Ala 1 5 <210> 210 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 210 Ala Leu Phe Thr Asn Thr Val Lys Ala 1 5 <210> 211 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 211 Ala Pro Arg Thr Asn Ile Thr Lys Ala 1 5 <210> 212 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 212 Ala Gly Ser Phe Ala Ser Thr Asp Ala 1 5 <210> 213 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 213 Ala Pro Gln Ser Asn Val Thr Lys Ala 1 5 <210> 214 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 214 Ala Trp Arg Tyr His Gly Ser Glu Ala 1 5 <210> 215 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 215 Ala Pro His Lys Ala Thr Lys Ser Ala 1 5 <210> 216 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 216 Ala Pro Leu Thr Asn Thr Ala Lys Ala 1 5 <210> 217 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 217 Ala Pro Leu Gly Asn Thr Ala Lys Ala 1 5 <210> 218 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 218 Ala Pro Leu Asp Asn Arg Leu Lys Ala 1 5 <210> 219 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 219 Ala Gly Arg Cys Ile Leu Ser Ala Ala 1 5 <210> 220 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 220 Ala Pro Leu Ile Asn Val Val Lys Ala 1 5 <210> 221 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 221 Ala Gly Arg Cys Ile Leu Lys Leu Ala 1 5 <210> 222 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 222 Ala Pro Ile Ser Gly Lys Asn Lys Ala 1 5 <210> 223 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 223 Ala Lys Ser Lys Ala Gly Gln Val Ala 1 5 <210> 224 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 224 Ala Gly Lys Ile His Leu Asp Ala Ala 1 5 <210> 225 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 225 Ala Gly His Thr Asn Ser Val Lys Ala 1 5 <210> 226 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 226 Ala Leu Phe Thr Asn Ser Thr Lys Ala 1 5 <210> 227 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 227 Ala Pro Ser Thr Asn Thr Val Lys Ala 1 5 <210> 228 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 228 Ala Arg Lys Ile His Leu Met Arg Ala 1 5 <210> 229 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 229 Ala Pro Ala Pro Asn Ser Val Lys Ala 1 5 <210> 230 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 230 Ala Gly Ile Thr Gly Asn Lys Ile Ala 1 5 <210> 231 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 231 Ala Gly Arg Val His Ile Glu Val Ala 1 5 <210> 232 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 232 Ala Arg Lys Val His Ile Glu Gly Ala 1 5 <210> 233 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 233 Ala Lys Lys Leu Asn Asn Ser Ile Ala 1 5 <210> 234 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 234 Ala Gly Ser Ile Ser Arg Ile Leu Ala 1 5 <210> 235 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 235 Ala Gly Tyr Met Gly Asn His Ile Ala 1 5 <210> 236 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 236 Ala Val Ser Ile Met Gly Trp Glu Ala 1 5 <210> 237 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 237 Ala Val Val Ser Asn Ala Ala Arg Ala 1 5 <210> 238 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 238 Ala Pro Arg Ala Lys Val Val Gln Ala 1 5 <210> 239 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 239 Ala Pro Leu Gly Asn Thr Val Arg Ala 1 5 <210> 240 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 240 Ala Pro Arg Thr Thr Thr Val Lys Ala 1 5 <210> 241 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 241 Ala Pro Gly Thr Asp Val Thr Lys Ala 1 5 <210> 242 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 242 Ala Leu Gly Arg Asn Val Thr Lys Ala 1 5 <210> 243 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 243 Ala Leu Lys His His Gly Pro Pro Ala 1 5 <210> 244 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 244 Ala Pro Leu Arg Ile Pro Thr Lys Ala 1 5 <210> 245 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 245 Ala Gln Ala Thr Asn Thr Val Arg Ala 1 5 <210> 246 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 246 Ala Ser Thr Gly Asn Ser Thr Arg Ala 1 5 <210> 247 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 247 Ala Pro Met His Asn Gly Ile Lys Ala 1 5 <210> 248 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 248 Ala Arg Lys Val His Thr Glu Val Ala 1 5 <210> 249 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 249 Ala Met Lys Tyr His Gly Pro Ala Ala 1 5 <210> 250 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 250 Ala Leu His Leu Asn Ser Ile Lys Ala 1 5 <210> 251 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 251 Ala Pro Ser Ile Asn Thr Ile Lys Ala 1 5 <210> 252 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 252 Ala Gly Arg Cys Ile Leu Ser Val Ala 1 5 <210> 253 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 253 Ala Lys Ala Lys Ala Gly Val Ala Ala 1 5 <210> 254 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 254 Ala Pro Ser Ser Asn Ala Ala Lys Ala 1 5 <210> 255 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 255 Ala Arg Lys Val Gln Ser Gly Val Ala 1 5 <210> 256 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 256 Ala Gly Lys Tyr Gln Gly Asp Met Ala 1 5 <210> 257 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 257 Ala Met Val Ile Pro Asn Val Ile Ala 1 5 <210> 258 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 258 Ala Gly Val Lys His Asn Ser Ile Ala 1 5 <210> 259 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 259 Ala Arg Lys His Gln Ser Asp Leu Ala 1 5 <210> 260 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 260 Ala Lys Gln Pro Asn Ala Val Lys Ala 1 5 <210> 261 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 261 Ala Phe Thr His Pro Asn Ser Val Ala 1 5 <210> 262 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 262 Ala Pro Arg Thr Ser Thr Val Lys Ala 1 5 <210> 263 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 263 Ala Arg Val Gly Val Lys Val Thr Ala 1 5 <210> 264 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 264 Ala Glu Gly Val His Ile Glu Val Ala 1 5 <210> 265 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 265 Ala Ser Lys Val His Ile Glu Val Ala 1 5 <210> 266 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 266 Ala Pro Leu Lys Asn Ala Ile Ser Ala 1 5 <210> 267 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 267 Ala Ser Arg Asn Asn Met Thr Lys Ala 1 5 <210> 268 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 268 Ala Arg Lys Val Gln Ala Gly Val Ala 1 5 <210> 269 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 269 Ala Gly Phe Thr Asn Asn Thr Lys Ala 1 5 <210> 270 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 270 Ala Pro Arg Lys Val Thr Gln Ser Ala 1 5 <210> 271 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 271 Ala Pro Leu Lys Lys Gly Ala Val Ala 1 5 <210> 272 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 272 Ala Pro Gly Lys Ser Thr Ala Lys Ala 1 5 <210> 273 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 273 Ala Gly Arg Cys Ile Leu Gly Cys Ala 1 5 <210> 274 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 274 Ala Leu Asn Ile Asn Ser Thr Lys Ala 1 5 <210> 275 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 275 Ala Pro Leu Gly Asn Gly Ala Lys Ala 1 5 <210> 276 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 276 Ala Gly Asn His Pro Asn Lys Val Ala 1 5 <210> 277 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 277 Ala Lys Asn Val His Pro Asn Ser Ala 1 5 <210> 278 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 278 Ala Pro Leu Lys Ala Lys Thr Ser Ala 1 5 <210> 279 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 279 Ala Pro Leu Gln Asn Ser Val Lys Ala 1 5 <210> 280 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 280 Ala Lys Tyr Lys Gln Gly Val Ser Ala 1 5 <210> 281 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 281 Ala Gly Ser Gly Met Ile Leu Glu Ala 1 5 <210> 282 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 282 Ala Arg Lys Val His Val Pro Val Ala 1 5 <210> 283 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 283 Ala Arg Lys Ile Gln Thr Met Ser Ala 1 5 <210> 284 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 284 Ala Leu Arg Gly Asn Lys Ile Gln Ala 1 5 <210> 285 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 285 Ala Pro Ile Ala Asn Asn Thr Arg Ala 1 5 <210> 286 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 286 Ala Phe His His Pro Asn Ala Val Ala 1 5 <210> 287 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 287 Ala Leu Lys Val His Ile Glu Val Ala 1 5 <210> 288 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 288 Ala Pro Arg Gly Val Lys Thr Thr Ala 1 5 <210> 289 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 289 Ala Gly Ser Phe Met Ser Thr Asp Ala 1 5 <210> 290 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 290 Ala Lys Gln Ile His Pro Asn Ser Ala 1 5 <210> 291 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 291 Ala Arg Trp Arg Asn Val Thr Lys Ala 1 5 <210> 292 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 292 Ala Arg Lys Tyr Arg Gly Asp Met Ala 1 5 <210> 293 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 293 Ala Pro Leu His Asn Arg Asn Asn Ala 1 5 <210> 294 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 294 Ala Pro His Ser Asn Arg Thr Val Ala 1 5 <210> 295 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 295 Ala Gly Ile Arg Asn Val Val Lys Ala 1 5 <210> 296 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 296 Ala Arg Ser Ser Lys Pro Asn Ser Ala 1 5 <210> 297 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 297 Ala Arg Thr Lys Asn Gly Val Pro Ala 1 5 <210> 298 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 298 Ala Arg Tyr His Ala Asn Ser Ile Ala 1 5 <210> 299 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 299 Ala Val Arg Thr Asn Ala Val Lys Ala 1 5 <210> 300 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 300 Ala Ile Val Ser Asn His Ser Lys Ala 1 5 <210> 301 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 301 Ala Pro Phe Asp Asn His Ile Arg Ala 1 5 <210> 302 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 302 Ala Pro Arg Lys Pro Asn Ala Ser Ala 1 5 <210> 303 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 303 Ala Arg Lys Val His Ile Gly Gly Ala 1 5 <210> 304 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 304 Ala Lys Arg Ala Ser Gly Pro Thr Ala 1 5 <210> 305 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 305 Ala Glu Cys Glu Ser Tyr Phe Lys Ala 1 5 <210> 306 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 306 Ala Pro Pro Gly Arg Lys Ser Ser Ala 1 5 <210> 307 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 307 Ala Arg Lys Tyr Gln Gly Asp Ile Ala 1 5 <210> 308 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 308 Ala Pro Ile Thr Asn Arg Ser Thr Ala 1 5 <210> 309 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 309 Ala Pro Arg Ser Val Gly Lys Ala Ala 1 5 <210> 310 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 310 Ala Cys Lys Met His Met Pro Asp Ala 1 5 <210> 311 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 311 Ala Pro Leu Asn Lys Lys Val Ala Ala 1 5 <210> 312 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 312 Ala Pro Ile Ala Asn Lys Val Ser Ala 1 5 <210> 313 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 313 Ala Pro Arg Ser Gly Val Thr Lys Ala 1 5 <210> 314 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 314 Ala Ile Arg His Pro Asn Val Val Ala 1 5 <210> 315 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 315 Ala Pro Tyr Gln Asn Ile Val Lys Ala 1 5 <210> 316 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 316 Ala Phe Thr Ala Asn Ser Thr Lys Ala 1 5 <210> 317 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 317 Ala Arg Lys His Gln Gly Asp Met Ala 1 5 <210> 318 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 318 Ala Pro Leu Arg Ile Leu Leu Lys Ala 1 5 <210> 319 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 319 Ala Glu Gly Ala His Ile Glu Val Ala 1 5 <210> 320 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 320 Ala Gly Tyr Ser Asn Ser Val Lys Ala 1 5 <210> 321 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 321 Ala Pro Leu Thr Asn Arg Ile Ser Ala 1 5 <210> 322 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 322 Ala Pro Pro His Ala Lys Lys Asn Ala 1 5 <210> 323 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 323 Ala Gly Ser Phe Leu Ser Thr Asp Ala 1 5 <210> 324 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 324 Ala Arg Lys Tyr Gln Phe Asp Leu Ala 1 5 <210> 325 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 325 Ala Arg Leu Arg Asn Thr Ala Lys Ala 1 5 <210> 326 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 326 Ala Arg Lys Met His Met Leu Asp Ala 1 5 <210> 327 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 327 Ala Pro Val Leu Asn Ser Ala Lys Ala 1 5 <210> 328 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 328 Ala Gly Ile Ser Arg Asn Ser Val Ala 1 5 <210> 329 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 329 Ala Arg Ser Asn Asn Thr Ile Lys Ala 1 5 <210> 330 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 330 Ala Gly Val Leu Arg Asn Ser Ile Ala 1 5 <210> 331 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 331 Ala Leu Leu Arg Asn Ser Thr Lys Ala 1 5 <210> 332 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 332 Ala Gln Ile His Pro Asn Ser Val Ala 1 5 <210> 333 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 333 Ala Tyr Ile His Asn Ser Thr Lys Ala 1 5 <210> 334 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 334 Ala Leu Leu Arg Ile Leu Leu Lys Ala 1 5 <210> 335 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 335 Ala Pro Arg Lys Asn Asn Asn Ser Ala 1 5 <210> 336 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 336 Ala Gly Ile Val Ala Asn Ala Ile Ala 1 5 <210> 337 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 337 Ala Pro Arg Lys Asn Thr Val Asn Ala 1 5 <210> 338 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 338 Ala Leu Leu Arg Ile Ser Thr Lys Ala 1 5 <210> 339 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 339 Ala Pro Gly Ser Arg Lys Ala Ala Ala 1 5 <210> 340 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 340 Ala Pro Lys Ala Lys Gly Gly Gly Ala 1 5 <210> 341 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 341 Ala Pro Ala Arg Gln Lys Ser Gly Ala 1 5 <210> 342 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 342 Ala Lys Ser Lys Leu Gly Val Val Ala 1 5 <210> 343 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 343 Ala Pro Arg Gly Thr Gly Lys Ala Ala 1 5 <210> 344 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 344 Ala Pro Val Ala Asp Val Thr Lys Ala 1 5 <210> 345 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 345 Ala Lys Ile Thr Asn Ala Ser Lys Ala 1 5 <210> 346 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 346 Ala Pro Arg Lys Gln Thr Thr Ser Ala 1 5 <210> 347 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 347 Ala Leu Leu Arg Asn Ala Asn Lys Ala 1 5 <210> 348 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 348 Ala Arg Lys Tyr Pro Val Ser Leu Ala 1 5 <210> 349 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 349 Ala Pro Arg Gly Asn Glu Val Lys Ala 1 5 <210> 350 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 350 Ala Trp Asp Glu Cys Val Thr Lys Ala 1 5 <210> 351 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 351 Ala Arg Lys Trp Gln Gln Phe Glu Ala 1 5 <210> 352 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 352 Ala Ser Leu Thr Asn Thr Val Lys Ala 1 5 <210> 353 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 353 Ala Gly Leu Ala Asn Ala Val Arg Ala 1 5 <210> 354 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 354 Ala Arg Ser Gly Asn Lys Val Asn Ala 1 5 <210> 355 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 355 Ala Pro Arg Asn Asn Ser Ser Lys Ala 1 5 <210> 356 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 356 Ala Phe Ser His Pro Asn Met Ile Ala 1 5 <210> 357 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 357 Ala Pro Met Thr Asn Lys Val Ser Ala 1 5 <210> 358 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 358 Ala Gly Ser Phe Gln Val Gly Ser Ala 1 5 <210> 359 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 359 Ala Leu Tyr Glu Phe Tyr Phe Lys Ala 1 5 <210> 360 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 360 Ala Pro Arg Ala Ser Gly Ser Lys Ala 1 5 <210> 361 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 361 Ala Gly Arg Phe Ile Trp Met Arg Ala 1 5 <210> 362 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 362 Ala Leu Gly Ser Asn Ser Val Arg Ala 1 5 <210> 363 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 363 Ala Gly Ser Phe Ile Val Leu Asp Ala 1 5 <210> 364 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 364 Ala Pro Gly His Lys Ala Ala Lys Ala 1 5 <210> 365 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 365 Ala Pro Ile Lys Ala Val Lys Thr Ala 1 5 <210> 366 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 366 Ala Pro Met Ser Asn Arg Ala Ala Ala 1 5 <210> 367 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 367 Ala Pro Leu Met Asn Lys Val Val Ala 1 5 <210> 368 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 368 Ala Arg Tyr Met Gly Asn Ser Ile Ala 1 5 <210> 369 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 369 Ala Pro Arg Val Ala Lys Pro Leu Ala 1 5 <210> 370 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 370 Ala Arg Leu Gly Asn Ala Ser Lys Ala 1 5 <210> 371 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 371 Ala Arg Lys Val Arg Val Gly Val Ala 1 5 <210> 372 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 372 Ala Ser Met Asn Asn Ser Thr Lys Ala 1 5 <210> 373 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 373 Ala Leu Val Arg Asn Asp Thr Arg Ala 1 5 <210> 374 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 374 Ala Pro Ala Met Asn Ile Thr Lys Ala 1 5 <210> 375 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 375 Ala Pro Leu Asn Lys Lys Leu Ser Ala 1 5 <210> 376 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 376 Ala Pro Tyr Arg Gln Cys Tyr Glu Ala 1 5 <210> 377 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 377 Ala Pro Lys Leu Ala Thr Thr Lys Ala 1 5 <210> 378 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 378 Ala Pro Ala Trp Val Lys Val Thr Ala 1 5 <210> 379 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 379 Ala Pro Leu Thr Asn Ala Val Lys Ala 1 5 <210> 380 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 380 Ala Gly Arg Leu His Ile Gly Val Ala 1 5 <210> 381 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 381 Ala Gly Val Ile Met Gly Arg Glu Ala 1 5 <210> 382 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 382 Ala Pro Leu Pro Asn Ser Ile Lys Ala 1 5 <210> 383 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 383 Ala Pro Ser Gly Lys Lys Thr Ser Ala 1 5 <210> 384 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 384 Ala Pro Arg Val Ser Gly Ala Lys Ala 1 5 <210> 385 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 385 Ala Arg Val Asp Asn Lys Val Lys Ala 1 5 <210> 386 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 386 Ala Arg Lys Val His Ile Arg Val Ala 1 5 <210> 387 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 387 Ala Gly Ser Ile Gln Gly Asp Met Ala 1 5 <210> 388 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 388 Ala Gly Lys Phe His Ser Thr Asp Ala 1 5 <210> 389 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 389 Ala Gly Ser Ile Ser Arg Ile Cys Ala 1 5 <210> 390 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 390 Ala Gly Ile Ser Ser Asn Lys Thr Ala 1 5 <210> 391 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 391 Ala Pro His Val Asn Thr Val Arg Ala 1 5 <210> 392 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 392 Ala Leu Arg Asn Lys Ala Ala Gln Ala 1 5 <210> 393 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 393 Ala Pro Arg Leu Asn Glu Val Lys Ala 1 5 <210> 394 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 394 Ala Gly Val His Met Asn Ser Ile Ala 1 5 <210> 395 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 395 Ala Pro Phe Thr Asp Ser Thr Lys Ala 1 5 <210> 396 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 396 Ala Ala Arg Tyr His Gly Ser Glu Ala 1 5 <210> 397 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 397 Ala Pro Ala Gly Asn Glu Val Lys Ala 1 5 <210> 398 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 398 Ala Lys Val His Ile Ile Glu Val Ala 1 5 <210> 399 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 399 Ala Gly Arg Cys Met Ala Glu Val Ala 1 5 <210> 400 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 400 Ala Pro Leu Ala Lys Ser Ser Lys Ala 1 5 <210> 401 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 401 Ala Pro Val Ser Asn Thr Thr Arg Ala 1 5 <210> 402 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 402 Ala Gly Val Val Thr Asn His Val Ala 1 5 <210> 403 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 403 Ala Trp Asp Glu Asp Val Thr Lys Ala 1 5 <210> 404 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 404 Ala Leu Thr Ala Asn Thr Val Lys Ala 1 5 <210> 405 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 405 Ala Leu Leu Arg Asp Thr Val Lys Ala 1 5 <210> 406 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 406 Ala Gln Arg Tyr His Gly Ser Glu Ala 1 5 <210> 407 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 407 Ala Arg Val Arg Arg Gly Ala Val Ala 1 5 <210> 408 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 408 Ala Pro Leu Val Lys Thr Thr Lys Ala 1 5 <210> 409 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 409 Ala Ala Lys Tyr His Gly Pro Pro Ala 1 5 <210> 410 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 410 Ala Gly Ile Arg Asn Asn Ser Thr Ala 1 5 <210> 411 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 411 Ala Lys Thr Gly Gly Lys Val Ala Ala 1 5 <210> 412 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 412 Ala Arg Phe Pro Ala Gly Ser Leu Ala 1 5 <210> 413 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 413 Ala Pro Gly Gly Lys Ala Asn Lys Ala 1 5 <210> 414 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 414 Ala Tyr Thr Lys Lys Ser Val Ala Ala 1 5 <210> 415 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 415 Ala Pro Gly Thr Asn Val Ile Lys Ala 1 5 <210> 416 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 416 Ala Gly Ser Gly Met Ile Leu Arg Ala 1 5 <210> 417 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 417 Ala Pro Lys Gly Thr Thr Ala Lys Ala 1 5 <210> 418 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 418 Ala Arg Lys Ile His Phe Gly Cys Ala 1 5 <210> 419 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 419 Ala Leu Thr Thr Asn Ser Ile Arg Ala 1 5 <210> 420 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 420 Ala Arg Trp Gln Ile Phe Thr Lys Ala 1 5 <210> 421 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 421 Ala Gly Ser Val Asn Ser Val Lys Ala 1 5 <210> 422 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 422 Ala Pro Ser Ala Thr Lys Asn Lys Ala 1 5 <210> 423 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 423 Ala Arg Lys Val His Ile Glu Cys Ala 1 5 <210> 424 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 424 Ala Ala Ala Gly Asn Gln Val Lys Ala 1 5 <210> 425 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 425 Ala Met Val Ser Asn Ala Thr Lys Ala 1 5 <210> 426 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 426 Ala Gly Ile Val Thr Asn His Val Ala 1 5 <210> 427 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 427 Ala Leu Ser Leu Asn Ala Thr Lys Ala 1 5 <210> 428 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 428 Ala Pro Leu Ala Asn Thr Val Lys Ala 1 5 <210> 429 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 429 Ala Pro Tyr Arg Asn Ala Thr Lys Ala 1 5 <210> 430 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 430 Ala Gly Arg Cys Ile Leu Lys Val Ala 1 5 <210> 431 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 431 Ala Trp Ser Arg Ser Pro Asn Ala Ala 1 5 <210> 432 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 432 Ala Met Ala Ser Asn Ser Val Arg Ala 1 5 <210> 433 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 433 Ala Met Ala Gln Asn Ser Val Lys Ala 1 5 <210> 434 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 434 Ala Gly Ile Gln Asn Asn His Ile Ala 1 5 <210> 435 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 435 Ala Pro Leu Lys Leu Lys Ala Ala Ala 1 5 <210> 436 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 436 Ala Pro Tyr His Ile Ala Thr Lys Ala 1 5 <210> 437 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 437 Ala Arg Trp Arg Met Leu Leu Lys Ala 1 5 <210> 438 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 438 Ala Pro Lys Lys Ser Gly Ser Pro Ala 1 5 <210> 439 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 439 Ala Arg Met Ser Asn Lys Thr Ser Ala 1 5 <210> 440 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 440 Ala Gly Arg Leu Thr Asn Gln Ile Ala 1 5 <210> 441 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 441 Ala Pro Arg Ala Gly Lys Ala Ala Ala 1 5 <210> 442 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 442 Ala Gly Thr Lys Asn Met Ile Lys Ala 1 5 <210> 443 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 443 Ala Arg Lys Ile His Leu Asp Thr Ala 1 5 <210> 444 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 444 Ala Arg Met Ser Asn Glu Ser Arg Ala 1 5 <210> 445 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 445 Ala Val Val Ser Asn Ala Ala Gln Ala 1 5 <210> 446 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 446 Ala Pro Arg Thr Val Gly Asn Lys Ala 1 5 <210> 447 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 447 Ala Pro Ser Val Asp Leu Thr Lys Ala 1 5 <210> 448 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 448 Ala Pro Arg Lys Asn Ser Ala Ala Ala 1 5 <210> 449 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 449 Ala Pro Ile Gly Asn Thr Thr Arg Ala 1 5 <210> 450 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 450 Ala Lys Tyr Ile Pro Gly Thr Leu Ala 1 5 <210> 451 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 451 Ala Pro Arg Lys Pro Gly Val Gln Ala 1 5 <210> 452 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 452 Ala Pro Arg Lys Thr Ser Ala Thr Ala 1 5 <210> 453 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 453 Ala Pro Phe Ala Asp Ser Thr Lys Ala 1 5 <210> 454 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 454 Ala Pro His Thr Lys Ser Lys Ser Ala 1 5 <210> 455 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 455 Ala Arg Lys Phe Arg Ser Thr Asp Ala 1 5 <210> 456 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 456 Ala Gly Ser Ile Arg Ser Asp Leu Ala 1 5 <210> 457 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 457 Ala Ser Tyr Glu Asp Thr Val Lys Ala 1 5 <210> 458 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 458 Ala Leu Leu Arg Ile Arg Leu Arg Ala 1 5 <210> 459 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 459 Ala Arg Arg Cys Ile Leu Arg Val Ala 1 5 <210> 460 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 460 Ala Gly Thr Leu Asn Ala Ile Lys Ala 1 5 <210> 461 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 461 Ala Gln Arg His Asn Asp Thr Arg Ala 1 5 <210> 462 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 462 Ala Arg Lys Leu Gln Ser Ala Gln Ala 1 5 <210> 463 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 463 Ala Lys Val Lys Gly Thr Ser Ala Ala 1 5 <210> 464 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 464 Ala Pro Arg Ser Val Gln Lys Ser Ala 1 5 <210> 465 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 465 Ala Pro Arg Gly Asn Asn Leu Lys Ala 1 5 <210> 466 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 466 Ala Pro Tyr His Asn Val Thr Lys Ala 1 5 <210> 467 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 467 Ala Gly Arg Cys Met Ala Arg Val Ala 1 5 <210> 468 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 468 Ala Arg Lys Trp Tyr Asp Thr Glu Ala 1 5 <210> 469 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 469 Ala Arg Lys Phe His Ser Ile Asp Ala 1 5 <210> 470 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 470 Ala Lys Lys Ile Asp Asn Arg Val Ala 1 5 <210> 471 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 471 Ala Gly Ala His Pro Asn Ser Leu Ala 1 5 <210> 472 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 472 Ala Pro Met Gly Arg Lys Ala Ala Ala 1 5 <210> 473 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 473 Ala Gly Lys Trp His Asp Thr Glu Ala 1 5 <210> 474 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 474 Ala Pro Phe Tyr Glu Phe Thr Lys Ala 1 5 <210> 475 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 475 Ala Pro Asn Arg Lys Ser Ala Thr Ala 1 5 <210> 476 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 476 Ala Pro Ser Gly Asn Ser Ser Arg Ala 1 5 <210> 477 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 477 Ala Ala Gln Gly Asn Thr Val Arg Ala 1 5 <210> 478 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 478 Ala Pro Arg Thr Lys Ser Ile Val Ala 1 5 <210> 479 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 479 Ala Pro His Leu Asn Leu Ala Lys Ala 1 5 <210> 480 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 480 Ala Pro Arg Gly Ala Lys Ser Ser Ala 1 5 <210> 481 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 481 Ala Pro Lys Ile Thr Lys Pro Ser Ala 1 5 <210> 482 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 482 Ala Arg Lys Tyr Arg Ser Asp Leu Ala 1 5 <210> 483 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 483 Ala Arg Lys Tyr Gln Ser Ser Leu Ala 1 5 <210> 484 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 484 Ala Arg Lys Trp Arg Gln Ser Glu Ala 1 5 <210> 485 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 485 Ala Val Lys Met His Met Pro Asp Ala 1 5 <210> 486 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 486 Ala Lys Val Gly Gly Lys Ala Ala Ala 1 5 <210> 487 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 487 Ala Pro Arg Gln Val Ser Lys Thr Ala 1 5 <210> 488 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 488 Ala Pro Ala Thr Thr Lys Val Lys Ala 1 5 <210> 489 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 489 Ala Arg Lys Ile His Asp Gly Pro Ala 1 5 <210> 490 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 490 Ala Gly Ile Leu Arg Asn Thr Ile Ala 1 5 <210> 491 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 491 Ala Pro Ser Ser Gly Lys Lys Val Ala 1 5 <210> 492 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 492 Ala Pro Arg Ser Ala Lys Pro Ala Ala 1 5 <210> 493 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 493 Ala Arg Trp Arg Ile Phe Thr Lys Ala 1 5 <210> 494 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 494 Ala Lys Val Asn Asn Leu Thr Lys Ala 1 5 <210> 495 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 495 Ala Pro Asn Ser Asn Ile Ile Lys Ala 1 5 <210> 496 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 496 Ala Arg Lys Trp His Asp Ala Glu Ala 1 5 <210> 497 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 497 Ala Gly Ser Phe His Thr Glu Thr Ala 1 5 <210> 498 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 498 Ala Arg Lys Tyr Pro Val Gly Phe Ala 1 5 <210> 499 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 499 Ala Leu Arg Gly Val Lys Val Thr Ala 1 5 <210> 500 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 500 Ala Pro Leu Gly Lys Lys Ile Ser Ala 1 5 <210> 501 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 501 Ala Arg Ala Thr Asn Glu Val Arg Ala 1 5 <210> 502 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 502 Ala Pro Gly Gly Asn Glu Val Arg Ala 1 5 <210> 503 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 503 Ala Leu Leu Gly Asn Ala Val Lys Ala 1 5 <210> 504 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 504 Ala Pro His Ser Asn Arg Val Ser Ala 1 5 <210> 505 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 505 Ala Pro Arg Ser Lys Asn Ala Val Ala 1 5 <210> 506 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 506 Ala Pro Ser Ile Asn Lys Val Lys Ala 1 5 <210> 507 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 507 Ala Pro Ala Ala Asn Thr Val Arg Ala 1 5 <210> 508 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 508 Ala Leu Cys Arg Asn Ser Ala Lys Ala 1 5 <210> 509 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 509 Ala Pro Leu Arg Ser Ala Val Lys Ala 1 5 <210> 510 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 510 Ala Pro Leu Lys Lys His Ala Ala Ala 1 5 <210> 511 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 511 Ala Pro Leu Thr Asn Thr Val Gly Ala 1 5 <210> 512 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 512 Ala Leu Leu Ile Ile Leu Val Lys Ala 1 5 <210> 513 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 513 Ala Leu Met Ser Asn Arg Ala Thr Ala 1 5 <210> 514 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 514 Ala Pro Leu Val Asn Ala Val Lys Ala 1 5 <210> 515 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 515 Ala Pro Ser Ser Lys Lys Ala Thr Ala 1 5 <210> 516 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 516 Ala Lys Phe Ile Ile Gly Ser Leu Ala 1 5 <210> 517 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 517 Ala Pro Ser Thr Asn Arg Val Thr Ala 1 5 <210> 518 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 518 Ala Pro Lys Ala Pro Asn Lys Ser Ala 1 5 <210> 519 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 519 Ala Lys Val Lys Leu Gly Ala Ala Ala 1 5 <210> 520 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 520 Ala Glu Val Ser Val Pro Asp Leu Ala 1 5 <210> 521 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 521 Ala Gly Ser Phe Ile Gly Thr Asp Ala 1 5 <210> 522 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 522 Ala Glu Val Ser Tyr Ser Thr Asp Ala 1 5 <210> 523 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 523 Ala Gly Arg Cys Ile Ala Glu Val Ala 1 5 <210> 524 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 524 Ala Arg Lys Tyr Gln Ser Asp Phe Ala 1 5 <210> 525 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 525 Ala Ala Leu Gly Asn Val Val Arg Ala 1 5 <210> 526 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 526 Ala Val Ala Ser Asn Val Val Lys Ala 1 5 <210> 527 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 527 Ala Leu Ala Gly Asn Ala Val Lys Ala 1 5 <210> 528 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 528 Ala Pro Ala Ser Asn Val Ala Arg Ala 1 5 <210> 529 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 529 Ala Tyr Gly His Pro Ile Val Ile Ala 1 5 <210> 530 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 530 Ala Leu Trp Leu Asn Leu Val Lys Ala 1 5 <210> 531 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 531 Ala Leu Ser Val Asn Leu Thr Lys Ala 1 5 <210> 532 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 532 Ala Pro Leu Arg Asn Ser Thr Lys Ala 1 5 <210> 533 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 533 Ala Leu Tyr His Pro Asn Lys Val Ala 1 5 <210> 534 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 534 Ala Arg Arg Tyr Gln Ser Asp Leu Ala 1 5 <210> 535 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 535 Ala Ala Lys Ala Met Lys Leu Gly Ala 1 5 <210> 536 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 536 Ala Ala Met Gly Asn Ala Ser Arg Ala 1 5 <210> 537 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 537 Ala Pro Arg Ala Leu Lys Ile Thr Ala 1 5 <210> 538 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 538 Ala Leu Ser Leu Asn Leu Val Lys Ala 1 5 <210> 539 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 539 Ala Leu Val Ala Asn Val Thr Lys Ala 1 5 <210> 540 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 540 Ala Lys Phe Val Pro Gly Thr Leu Ala 1 5 <210> 541 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 541 Ala Ser Ile His Pro Asn Ala Ile Ala 1 5 <210> 542 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 542 Ala Lys Met Lys Val Gly Val Ser Ala 1 5 <210> 543 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 543 Ala Pro Val Gly Ala Lys Lys Gly Ala 1 5 <210> 544 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 544 Ala Ser Tyr Glu Tyr Thr Val Lys Ala 1 5 <210> 545 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 545 Ala Gln Glu Val Ser Val Asp Leu Ala 1 5 <210> 546 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 546 Ala Gly Val Ile Met Glu Ser Glu Ala 1 5 <210> 547 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 547 Ala Glu Gly Ala Cys Ile Glu Val Ala 1 5 <210> 548 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 548 Ala Val Leu Phe Arg Asn Ile Pro Ala 1 5 <210> 549 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 549 Ala Pro Lys Arg Ser Asn Ala Thr Ala 1 5 <210> 550 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 550 Ala Leu Arg Gln Asn Leu Val Lys Ala 1 5 <210> 551 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 551 Ala Leu Arg Ile Asn Asn Val Lys Ala 1 5 <210> 552 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 552 Ala Pro Arg Lys Ala Gly Thr Val Ala 1 5 <210> 553 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 553 Ala Gln Arg Leu Asn Asn Thr Lys Ala 1 5 <210> 554 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 554 Ala Pro Leu Ala Asp Leu Thr Lys Ala 1 5 <210> 555 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 555 Ala Pro Leu Ala Asp Thr Val Lys Ala 1 5 <210> 556 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 556 Ala Gly Arg Cys Ala Ile Glu Val Ala 1 5 <210> 557 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 557 Ala Arg Lys Tyr Gln Pro Asp Leu Ala 1 5 <210> 558 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 558 Ala Arg Lys Ile Arg Leu Asp Ala Ala 1 5 <210> 559 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 559 Ala Arg Arg Cys Ile Leu Ser Ala Ala 1 5 <210> 560 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 560 Ala Glu Val Ser Ser Pro Asp Leu Ala 1 5 <210> 561 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 561 Ala Gly Val Ile Met Gly Ser Glu Ala 1 5 <210> 562 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 562 Ala Val Lys Tyr Gln Ser Asp Leu Ala 1 5 <210> 563 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 563 Ala Pro Arg Gln Ala Lys Val Ala Ala 1 5 <210> 564 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 564 Ala Gln Met Thr Asn Gln Val Lys Ala 1 5 <210> 565 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 565 Ala Gly Gln Ser Asn Gln Thr Arg Ala 1 5 <210> 566 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 566 Ala Pro Val Arg Ala Ala Thr Lys Ala 1 5 <210> 567 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 567 Ala Lys Thr Lys Ser Ala Asn Ser Ala 1 5 <210> 568 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 568 Ala Phe Ser Ala His Pro Asn Lys Ala 1 5 <210> 569 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 569 Ala Arg Ile Lys Gly Gly Val Pro Ala 1 5 <210> 570 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 570 Ala Pro Trp Phe Arg Asp Asn Ala Ala 1 5 <210> 571 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 571 Ala Pro Ser Lys Gly Lys Ser Asn Ala 1 5 <210> 572 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 572 Ala Pro Arg Thr Asn Asn Thr Val Ala 1 5 <210> 573 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 573 Ala Pro Lys Thr Ser Lys Ser Ser Ala 1 5 <210> 574 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 574 Ala Arg Lys Tyr Gln Ala Ala Ser Ala 1 5 <210> 575 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 575 Ala Pro Lys Ala Asn Leu Ala Lys Ala 1 5 <210> 576 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 576 Ala Gly Val Ile Met Gly Pro Glu Ala 1 5 <210> 577 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 577 Ala Ser Tyr Gly Ile Arg Leu Lys Ala 1 5 <210> 578 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 578 Ala Pro Arg Thr Gly Ala Thr Lys Ala 1 5 <210> 579 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 579 Ala Ala Arg Gly Val Lys Val Thr Ala 1 5 <210> 580 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 580 Ala Gly Ser Ile Arg Ser Asp Met Ala 1 5 <210> 581 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 581 Ala Arg Ile Val Ile Leu Val Lys Ala 1 5 <210> 582 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 582 Ala Leu Leu Arg Ile Pro Thr Lys Ala 1 5 <210> 583 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 583 Ala Ala Trp Gly Val Lys Val Thr Ala 1 5 <210> 584 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 584 Ala Pro Thr Lys Lys Thr Ala Val Ala 1 5 <210> 585 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 585 Ala Ile Met Leu Asn Gln Val Lys Ala 1 5 <210> 586 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 586 Ala Pro Gly Leu Asn Tyr Val Lys Ala 1 5 <210> 587 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 587 Ala Arg Lys Leu His Ser Gly Pro Ala 1 5 <210> 588 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 588 Ala Lys Trp Lys Ser Gly Ala Ser Ala 1 5 <210> 589 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 589 Ala Trp Lys Ala Gln Lys Thr Ser Ala 1 5 <210> 590 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 590 Ala Pro Arg Thr Lys Gly Thr Ala Ala 1 5 <210> 591 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 591 Ala Pro Arg His Ser Lys Val Thr Ala 1 5 <210> 592 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 592 Ala Gly Thr Ala Asn Val Thr Lys Ala 1 5 <210> 593 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 593 Ala Leu Leu Gly Asn Met Thr Lys Ala 1 5 <210> 594 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 594 Ala Arg Lys Val His Ile Glu Ile Ala 1 5 <210> 595 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 595 Ala Glu Val Ser Cys Gly Pro Pro Ala 1 5 <210> 596 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 596 Ala Lys Ala Lys Ala Gly Val Thr Ala 1 5 <210> 597 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 597 Ala Leu Ile Leu Asn Ala Thr Lys Ala 1 5 <210> 598 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 598 Ala Arg Ser Val Asn Leu Thr Lys Ala 1 5 <210> 599 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 599 Ala Ser Tyr Glu Tyr Gly Ala Lys Ala 1 5 <210> 600 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <400> 600 Ala Leu Lys Tyr Arg Gly Pro Pro Ala 1 5 <210> 601 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 601 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val His Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 602 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 602 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Tyr Gln Ser Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 603 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 603 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Thr Asn Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 604 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 604 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Lys Tyr His Gly Pro Pro Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 605 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 605 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Tyr Gln Gly Asp Met Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 606 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 606 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Phe His Ser Thr Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 607 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 607 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys His His Gly Leu Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 608 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 608 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Gly Thr Asn Val Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 609 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 609 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Met His Met Pro Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 610 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 610 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Lys Lys Ile Val Gln Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 611 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 611 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Gly Lys Lys Thr Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 612 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 612 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Gly Val Lys Val Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 613 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 613 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Ala Lys Ser Lys Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 614 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 614 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Thr Lys Gly Ala Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 615 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 615 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Gly Arg Lys Ala Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 616 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 616 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Ile His Leu Asp Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 617 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 617 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Tyr His Asn Ala Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 618 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 618 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Trp His Asp Thr Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 619 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 619 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Val Ala Asn Val Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 620 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 620 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val His Ile Gly Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 621 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 621 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Asn Asn Ser Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 622 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 622 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Arg Tyr His Gly Ser Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 623 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 623 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Tyr Gly His Pro Asn Val Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 624 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 624 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Phe Thr Asn Ser Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 625 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 625 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val Gln Val Gly Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 626 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 626 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Ile Leu Arg Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 627 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 627 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Ile Lys Thr Gly Val Pro Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 628 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 628 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Trp His Asn Ser Tyr Pro His Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 629 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 629 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Val Asn Leu Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 630 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 630 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Ser Asn Leu Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 631 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 631 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Phe His Thr Glu Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 632 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 632 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Phe Ile Leu Asp Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 633 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 633 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Val Lys Gln Asn Gln Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 634 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 634 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Val Arg Ser Asn Lys Val Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 635 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 635 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Ile Leu Arg Trp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 636 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 636 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Trp Gln Gln Ser Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 637 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 637 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Lys Asn Gly Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 638 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 638 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Leu Lys Asn Ala Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 639 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 639 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ala Ile Asn His Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 640 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 640 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Val Leu Ser Asn Arg Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 641 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 641 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Ala Asn Thr Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 642 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 642 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Arg Trp His Gly Asp Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 643 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 643 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Arg Asn Ala Asn Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 644 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 644 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Thr Asn Leu Ile Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 645 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 645 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Leu Gln Val Gly Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 646 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 646 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Glu Gly Ala Tyr Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 647 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 647 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Met Ala Asn Leu Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 648 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 648 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Thr Val Asn Ala Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 649 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 649 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Val Thr Lys Lys Ala Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 650 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 650 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Met Pro Asn Ser Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 651 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 651 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Ile Gln Ser Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 652 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 652 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Arg Asn Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 653 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 653 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly His Leu Ser Asn His Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 654 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 654 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Met Ser Asn Arg Ala Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 655 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 655 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Tyr Gln Leu Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 656 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 656 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro His Ser Asn Ser Ser Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 657 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 657 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Leu Gly Asn Ala Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 658 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 658 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Ile Arg Gly Asp Met Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 659 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 659 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Arg Ile Arg Leu Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 660 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 660 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val Tyr Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 661 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 661 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Trp Lys Val His Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 662 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 662 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Ser Ala Lys Pro Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 663 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 663 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Ala Asn Leu Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 664 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 664 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Gly Ser Ala Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 665 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 665 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Leu His Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 666 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 666 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Arg Ile Ser Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 667 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 667 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Trp Gln Ser His Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 668 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 668 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Lys Val His Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 669 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 669 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Arg Cys Ile Leu Arg Trp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 670 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 670 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Thr Lys Ser Gly Ile Asn Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 671 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 671 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Ile Asn Ser Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 672 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 672 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Leu Asn Leu Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 673 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 673 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Gly Asn Met Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 674 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 674 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Tyr His Asn Ala Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 675 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 675 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Ser Asn Leu Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 676 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 676 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Arg His Lys Ser Asn Asn Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 677 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 677 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Lys Ser Asn Ala Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 678 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 678 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Phe Ser Asn Ser Ser Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 679 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 679 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Ile Leu Gly Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 680 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 680 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ala Ser Asn Ser Ser Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 681 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 681 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Lys Tyr Gln Ser Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 682 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 682 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Ile Leu Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 683 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 683 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Thr Gln Asn Ser Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 684 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 684 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Ile Ala Asn Ala Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 685 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 685 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Phe His Ala Met Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 686 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 686 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Arg Ser Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 687 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 687 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Tyr Ser Pro Asn Ser Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 688 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 688 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Lys Val His Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 689 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 689 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Ile Ser Pro Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 690 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 690 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val His Ile Glu Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 691 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 691 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Arg Met Asn Ser Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 692 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 692 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ala His Lys Val Lys Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 693 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 693 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Cys Lys His His Gly Leu Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 694 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 694 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Leu Ser Asn Ala Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 695 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 695 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Ala Asn Arg Thr Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 696 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 696 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Ile Leu Arg Cys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 697 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 697 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gln Glu Asp Ser Phe Asp Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 698 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 698 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Val Ser Ile Met Gly Leu Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 699 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 699 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Gly Thr Asn Leu Ile Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 700 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 700 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Thr Ser Gly Asn Ser Val Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 701 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 701 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Phe Pro Val Gly Ser Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 702 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 702 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Val Thr Lys Ala Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 703 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 703 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Phe His Ser Thr Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 704 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 704 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala His Lys Ala Leu Val His Gly Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 705 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 705 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Thr Asn Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 706 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 706 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Lys Lys Ile Val Gln Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 707 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 707 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Asp Asn Arg Thr Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 708 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 708 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Val Asn Lys Thr Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 709 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 709 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ile Met Ser Asn Lys Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 710 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 710 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Phe Thr Asn Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 711 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 711 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Thr Asn Ile Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 712 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 712 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Phe Ala Ser Thr Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 713 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 713 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Gln Ser Asn Val Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 714 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 714 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Trp Arg Tyr His Gly Ser Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 715 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 715 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro His Lys Ala Thr Lys Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 716 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 716 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Thr Asn Thr Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 717 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 717 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Gly Asn Thr Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 718 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 718 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Asp Asn Arg Leu Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 719 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 719 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Ile Leu Ser Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 720 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 720 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Ile Asn Val Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 721 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 721 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Ile Leu Lys Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 722 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 722 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ile Ser Gly Lys Asn Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 723 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 723 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Ser Lys Ala Gly Gln Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 724 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 724 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Lys Ile His Leu Asp Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 725 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 725 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly His Thr Asn Ser Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 726 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 726 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Phe Thr Asn Ser Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 727 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 727 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Thr Asn Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 728 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 728 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Ile His Leu Met Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 729 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 729 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ala Pro Asn Ser Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 730 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 730 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ile Thr Gly Asn Lys Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 731 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 731 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Val His Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 732 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 732 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val His Ile Glu Gly Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 733 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 733 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Lys Leu Asn Asn Ser Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 734 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 734 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Ile Ser Arg Ile Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 735 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 735 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Tyr Met Gly Asn His Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 736 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 736 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Val Ser Ile Met Gly Trp Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 737 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 737 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Val Val Ser Asn Ala Ala Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 738 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 738 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Ala Lys Val Val Gln Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 739 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 739 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Gly Asn Thr Val Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 740 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 740 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Thr Thr Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 741 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 741 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Gly Thr Asp Val Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 742 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 742 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Gly Arg Asn Val Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 743 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 743 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Lys His His Gly Pro Pro Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 744 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 744 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Arg Ile Pro Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 745 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 745 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gln Ala Thr Asn Thr Val Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 746 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 746 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ser Thr Gly Asn Ser Thr Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 747 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 747 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Met His Asn Gly Ile Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 748 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 748 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val His Thr Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 749 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 749 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Met Lys Tyr His Gly Pro Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 750 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 750 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu His Leu Asn Ser Ile Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 751 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 751 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Ile Asn Thr Ile Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 752 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 752 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Ile Leu Ser Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 753 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 753 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Ala Lys Ala Gly Val Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 754 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 754 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Ser Asn Ala Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 755 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 755 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val Gln Ser Gly Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 756 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 756 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Lys Tyr Gln Gly Asp Met Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 757 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 757 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Met Val Ile Pro Asn Val Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 758 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 758 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Val Lys His Asn Ser Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 759 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 759 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys His Gln Ser Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 760 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 760 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Gln Pro Asn Ala Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 761 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 761 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Phe Thr His Pro Asn Ser Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 762 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 762 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Thr Ser Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 763 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 763 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Val Gly Val Lys Val Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 764 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 764 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Glu Gly Val His Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 765 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 765 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ser Lys Val His Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 766 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 766 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Lys Asn Ala Ile Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 767 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 767 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ser Arg Asn Asn Met Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 768 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 768 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val Gln Ala Gly Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 769 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 769 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Phe Thr Asn Asn Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 770 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 770 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Lys Val Thr Gln Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 771 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 771 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Lys Lys Gly Ala Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 772 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 772 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Gly Lys Ser Thr Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 773 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 773 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Ile Leu Gly Cys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 774 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 774 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Asn Ile Asn Ser Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 775 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 775 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Gly Asn Gly Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 776 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 776 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Asn His Pro Asn Lys Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 777 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 777 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Asn Val His Pro Asn Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 778 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 778 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Lys Ala Lys Thr Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 779 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 779 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Gln Asn Ser Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 780 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 780 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Tyr Lys Gln Gly Val Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 781 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 781 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Gly Met Ile Leu Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 782 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 782 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val His Val Pro Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 783 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 783 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Ile Gln Thr Met Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 784 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 784 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Arg Gly Asn Lys Ile Gln Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 785 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 785 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ile Ala Asn Asn Thr Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 786 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 786 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Phe His His Pro Asn Ala Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 787 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 787 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Lys Val His Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 788 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 788 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Gly Val Lys Thr Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 789 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 789 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Phe Met Ser Thr Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 790 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 790 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Gln Ile His Pro Asn Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 791 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 791 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Trp Arg Asn Val Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 792 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 792 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Tyr Arg Gly Asp Met Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 793 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 793 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu His Asn Arg Asn Asn Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 794 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 794 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro His Ser Asn Arg Thr Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 795 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 795 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ile Arg Asn Val Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 796 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 796 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Ser Ser Lys Pro Asn Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 797 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 797 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Thr Lys Asn Gly Val Pro Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 798 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 798 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Tyr His Ala Asn Ser Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 799 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 799 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Val Arg Thr Asn Ala Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 800 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 800 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ile Val Ser Asn His Ser Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 801 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 801 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Phe Asp Asn His Ile Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 802 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 802 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Lys Pro Asn Ala Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 803 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 803 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val His Ile Gly Gly Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 804 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 804 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Arg Ala Ser Gly Pro Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 805 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 805 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Glu Cys Glu Ser Tyr Phe Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 806 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 806 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Pro Gly Arg Lys Ser Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 807 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 807 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Tyr Gln Gly Asp Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 808 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 808 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ile Thr Asn Arg Ser Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 809 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 809 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Ser Val Gly Lys Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 810 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 810 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Cys Lys Met His Met Pro Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 811 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 811 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Asn Lys Lys Val Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 812 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 812 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ile Ala Asn Lys Val Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 813 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 813 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Ser Gly Val Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 814 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 814 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ile Arg His Pro Asn Val Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 815 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 815 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Tyr Gln Asn Ile Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 816 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 816 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Phe Thr Ala Asn Ser Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 817 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 817 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys His Gln Gly Asp Met Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 818 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 818 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Arg Ile Leu Leu Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 819 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 819 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Glu Gly Ala His Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 820 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 820 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Tyr Ser Asn Ser Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 821 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 821 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Thr Asn Arg Ile Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 822 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 822 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Pro His Ala Lys Lys Asn Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 823 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 823 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Phe Leu Ser Thr Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 824 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 824 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Tyr Gln Phe Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 825 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 825 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Leu Arg Asn Thr Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 826 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 826 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Met His Met Leu Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 827 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 827 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Val Leu Asn Ser Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 828 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 828 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ile Ser Arg Asn Ser Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 829 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 829 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Ser Asn Asn Thr Ile Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 830 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 830 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Val Leu Arg Asn Ser Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 831 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 831 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Arg Asn Ser Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 832 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 832 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gln Ile His Pro Asn Ser Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 833 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 833 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Tyr Ile His Asn Ser Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 834 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 834 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Arg Ile Leu Leu Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 835 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 835 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Lys Asn Asn Asn Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 836 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 836 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ile Val Ala Asn Ala Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 837 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 837 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Lys Asn Thr Val Asn Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 838 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 838 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Arg Ile Ser Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 839 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 839 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Gly Ser Arg Lys Ala Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 840 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 840 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Lys Ala Lys Gly Gly Gly Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 841 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 841 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ala Arg Gln Lys Ser Gly Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 842 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 842 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Ser Lys Leu Gly Val Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 843 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 843 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Gly Thr Gly Lys Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 844 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 844 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Val Ala Asp Val Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 845 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 845 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Ile Thr Asn Ala Ser Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 846 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 846 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Lys Gln Thr Thr Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 847 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 847 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Arg Asn Ala Asn Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 848 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 848 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Tyr Pro Val Ser Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 849 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 849 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Gly Asn Glu Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 850 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 850 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Trp Asp Glu Cys Val Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 851 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 851 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Trp Gln Gln Phe Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 852 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 852 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ser Leu Thr Asn Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 853 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 853 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Leu Ala Asn Ala Val Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 854 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 854 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Ser Gly Asn Lys Val Asn Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 855 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 855 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Asn Asn Ser Ser Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 856 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 856 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Phe Ser His Pro Asn Met Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 857 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 857 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Met Thr Asn Lys Val Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 858 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 858 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Phe Gln Val Gly Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 859 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 859 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Tyr Glu Phe Tyr Phe Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 860 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 860 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Ala Ser Gly Ser Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 861 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 861 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Phe Ile Trp Met Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 862 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 862 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Gly Ser Asn Ser Val Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 863 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 863 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Phe Ile Val Leu Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 864 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 864 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Gly His Lys Ala Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 865 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 865 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ile Lys Ala Val Lys Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 866 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 866 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Met Ser Asn Arg Ala Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 867 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 867 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Met Asn Lys Val Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 868 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 868 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Tyr Met Gly Asn Ser Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 869 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 869 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Val Ala Lys Pro Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 870 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 870 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Leu Gly Asn Ala Ser Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 871 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 871 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val Arg Val Gly Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 872 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 872 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ser Met Asn Asn Ser Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 873 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 873 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Val Arg Asn Asp Thr Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 874 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 874 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ala Met Asn Ile Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 875 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 875 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Asn Lys Lys Leu Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 876 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 876 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Tyr Arg Gln Cys Tyr Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 877 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 877 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Lys Leu Ala Thr Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 878 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 878 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ala Trp Val Lys Val Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 879 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 879 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Thr Asn Ala Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 880 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 880 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Leu His Ile Gly Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 881 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 881 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Val Ile Met Gly Arg Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 882 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 882 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Pro Asn Ser Ile Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 883 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 883 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Gly Lys Lys Thr Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 884 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 884 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Val Ser Gly Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 885 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 885 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Val Asp Asn Lys Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 886 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 886 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val His Ile Arg Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 887 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 887 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Ile Gln Gly Asp Met Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 888 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 888 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Lys Phe His Ser Thr Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 889 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 889 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Ile Ser Arg Ile Cys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 890 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 890 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ile Ser Ser Asn Lys Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 891 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 891 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro His Val Asn Thr Val Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 892 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 892 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Arg Asn Lys Ala Ala Gln Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 893 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 893 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Leu Asn Glu Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 894 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 894 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Val His Met Asn Ser Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 895 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 895 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Phe Thr Asp Ser Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 896 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 896 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ala Arg Tyr His Gly Ser Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 897 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 897 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ala Gly Asn Glu Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 898 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 898 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Val His Ile Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 899 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 899 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Met Ala Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 900 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 900 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Ala Lys Ser Ser Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 901 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 901 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Val Ser Asn Thr Thr Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 902 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 902 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Val Val Thr Asn His Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 903 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 903 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Trp Asp Glu Asp Val Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 904 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 904 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Thr Ala Asn Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 905 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 905 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Arg Asp Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 906 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 906 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gln Arg Tyr His Gly Ser Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 907 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 907 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Val Arg Arg Gly Ala Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 908 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 908 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Val Lys Thr Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 909 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 909 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ala Lys Tyr His Gly Pro Pro Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 910 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 910 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ile Arg Asn Asn Ser Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 911 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 911 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Thr Gly Gly Lys Val Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 912 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 912 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Phe Pro Ala Gly Ser Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 913 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 913 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Gly Gly Lys Ala Asn Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 914 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 914 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Tyr Thr Lys Lys Ser Val Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 915 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 915 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Gly Thr Asn Val Ile Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 916 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 916 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Gly Met Ile Leu Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 917 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 917 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Lys Gly Thr Thr Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 918 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 918 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Ile His Phe Gly Cys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 919 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 919 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Thr Thr Asn Ser Ile Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 920 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 920 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Trp Gln Ile Phe Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 921 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 921 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Val Asn Ser Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 922 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 922 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Ala Thr Lys Asn Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 923 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 923 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val His Ile Glu Cys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 924 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 924 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ala Ala Gly Asn Gln Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 925 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 925 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Met Val Ser Asn Ala Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 926 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 926 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ile Val Thr Asn His Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 927 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 927 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Ser Leu Asn Ala Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 928 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 928 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Ala Asn Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 929 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 929 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Tyr Arg Asn Ala Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 930 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 930 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Ile Leu Lys Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 931 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 931 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Trp Ser Arg Ser Pro Asn Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 932 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 932 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Met Ala Ser Asn Ser Val Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 933 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 933 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Met Ala Gln Asn Ser Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 934 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 934 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ile Gln Asn Asn His Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 935 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 935 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Lys Leu Lys Ala Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 936 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 936 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Tyr His Ile Ala Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 937 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 937 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Trp Arg Met Leu Leu Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 938 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 938 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Lys Lys Ser Gly Ser Pro Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 939 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 939 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Met Ser Asn Lys Thr Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 940 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 940 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Leu Thr Asn Gln Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 941 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 941 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Ala Gly Lys Ala Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 942 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 942 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Thr Lys Asn Met Ile Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 943 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 943 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Ile His Leu Asp Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 944 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 944 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Met Ser Asn Glu Ser Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 945 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 945 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Val Val Ser Asn Ala Ala Gln Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 946 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 946 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Thr Val Gly Asn Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 947 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 947 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Val Asp Leu Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 948 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 948 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Lys Asn Ser Ala Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 949 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 949 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ile Gly Asn Thr Thr Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 950 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 950 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Tyr Ile Pro Gly Thr Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 951 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 951 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Lys Pro Gly Val Gln Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 952 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 952 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Lys Thr Ser Ala Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 953 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 953 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Phe Ala Asp Ser Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 954 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 954 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro His Thr Lys Ser Lys Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 955 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 955 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Phe Arg Ser Thr Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 956 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 956 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Ile Arg Ser Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 957 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 957 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ser Tyr Glu Asp Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 958 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 958 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Arg Ile Arg Leu Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 959 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 959 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Arg Cys Ile Leu Arg Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 960 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 960 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Thr Leu Asn Ala Ile Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 961 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 961 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gln Arg His Asn Asp Thr Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 962 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 962 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Leu Gln Ser Ala Gln Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 963 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 963 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Val Lys Gly Thr Ser Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 964 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 964 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Ser Val Gln Lys Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 965 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 965 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Gly Asn Asn Leu Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 966 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 966 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Tyr His Asn Val Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 967 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 967 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Met Ala Arg Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 968 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 968 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Trp Tyr Asp Thr Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 969 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 969 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Phe His Ser Ile Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 970 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 970 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Lys Ile Asp Asn Arg Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 971 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 971 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ala His Pro Asn Ser Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 972 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 972 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Met Gly Arg Lys Ala Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 973 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 973 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Lys Trp His Asp Thr Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 974 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 974 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Phe Tyr Glu Phe Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 975 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 975 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Asn Arg Lys Ser Ala Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 976 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 976 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Gly Asn Ser Ser Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 977 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 977 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ala Gln Gly Asn Thr Val Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 978 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 978 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Thr Lys Ser Ile Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 979 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 979 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro His Leu Asn Leu Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 980 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 980 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Gly Ala Lys Ser Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 981 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 981 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Lys Ile Thr Lys Pro Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 982 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 982 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Tyr Arg Ser Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 983 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 983 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Tyr Gln Ser Ser Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 984 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 984 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Trp Arg Gln Ser Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 985 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 985 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Val Lys Met His Met Pro Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 986 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 986 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Val Gly Gly Lys Ala Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 987 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 987 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Gln Val Ser Lys Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 988 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 988 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ala Thr Thr Lys Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 989 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 989 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Ile His Asp Gly Pro Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 990 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 990 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ile Leu Arg Asn Thr Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 991 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 991 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Ser Gly Lys Lys Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 992 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 992 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Ser Ala Lys Pro Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 993 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 993 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Trp Arg Ile Phe Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 994 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 994 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Val Asn Asn Leu Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 995 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 995 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Asn Ser Asn Ile Ile Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 996 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 996 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Trp His Asp Ala Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 997 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 997 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Phe His Thr Glu Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 998 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 998 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Tyr Pro Val Gly Phe Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 999 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 999 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Arg Gly Val Lys Val Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1000 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1000 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Gly Lys Lys Ile Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1001 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1001 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Ala Thr Asn Glu Val Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1002 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1002 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Gly Gly Asn Glu Val Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1003 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1003 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Gly Asn Ala Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1004 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1004 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro His Ser Asn Arg Val Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1005 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1005 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Ser Lys Asn Ala Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1006 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1006 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Ile Asn Lys Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1007 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1007 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ala Ala Asn Thr Val Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1008 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1008 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Cys Arg Asn Ser Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1009 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1009 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Arg Ser Ala Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1010 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1010 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Lys Lys His Ala Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1011 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1011 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Thr Asn Thr Val Gly Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1012 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1012 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Ile Ile Leu Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1013 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1013 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Met Ser Asn Arg Ala Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1014 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1014 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Val Asn Ala Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1015 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1015 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Ser Lys Lys Ala Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1016 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1016 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Phe Ile Ile Gly Ser Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1017 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1017 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Thr Asn Arg Val Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1018 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1018 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Lys Ala Pro Asn Lys Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1019 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1019 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Val Lys Leu Gly Ala Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1020 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1020 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Glu Val Ser Val Pro Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1021 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1021 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Phe Ile Gly Thr Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1022 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1022 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Glu Val Ser Tyr Ser Thr Asp Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1023 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1023 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Ile Ala Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1024 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1024 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Tyr Gln Ser Asp Phe Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1025 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1025 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ala Leu Gly Asn Val Val Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1026 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1026 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Val Ala Ser Asn Val Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1027 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1027 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Ala Gly Asn Ala Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1028 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1028 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ala Ser Asn Val Ala Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1029 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1029 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Tyr Gly His Pro Ile Val Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1030 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1030 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Trp Leu Asn Leu Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1031 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1031 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Ser Val Asn Leu Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1032 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1032 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Arg Asn Ser Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1033 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1033 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Tyr His Pro Asn Lys Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1034 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1034 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Arg Tyr Gln Ser Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1035 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1035 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ala Lys Ala Met Lys Leu Gly Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1036 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1036 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ala Met Gly Asn Ala Ser Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1037 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1037 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Ala Leu Lys Ile Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1038 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1038 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Ser Leu Asn Leu Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1039 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1039 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Val Ala Asn Val Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1040 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1040 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Phe Val Pro Gly Thr Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1041 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1041 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ser Ile His Pro Asn Ala Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1042 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1042 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Met Lys Val Gly Val Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1043 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1043 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Val Gly Ala Lys Lys Gly Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1044 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1044 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ser Tyr Glu Tyr Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1045 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1045 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gln Glu Val Ser Val Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1046 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1046 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Val Ile Met Glu Ser Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1047 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1047 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Glu Gly Ala Cys Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1048 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1048 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Val Leu Phe Arg Asn Ile Pro Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1049 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1049 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Lys Arg Ser Asn Ala Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1050 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1050 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Arg Gln Asn Leu Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1051 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1051 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Arg Ile Asn Asn Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1052 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1052 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Lys Ala Gly Thr Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1053 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1053 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gln Arg Leu Asn Asn Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1054 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1054 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Ala Asp Leu Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1055 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1055 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Leu Ala Asp Thr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1056 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1056 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Arg Cys Ala Ile Glu Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1057 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1057 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Tyr Gln Pro Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1058 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1058 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Ile Arg Leu Asp Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1059 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1059 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Arg Cys Ile Leu Ser Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1060 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1060 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Glu Val Ser Ser Pro Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1061 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1061 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Val Ile Met Gly Ser Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1062 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1062 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Val Lys Tyr Gln Ser Asp Leu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1063 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1063 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Gln Ala Lys Val Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1064 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1064 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gln Met Thr Asn Gln Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1065 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1065 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Gln Ser Asn Gln Thr Arg Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1066 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1066 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Val Arg Ala Ala Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1067 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1067 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Thr Lys Ser Ala Asn Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1068 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1068 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Phe Ser Ala His Pro Asn Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1069 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1069 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Ile Lys Gly Gly Val Pro Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1070 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1070 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Trp Phe Arg Asp Asn Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1071 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1071 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Ser Lys Gly Lys Ser Asn Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1072 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1072 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Thr Asn Asn Thr Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1073 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1073 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Lys Thr Ser Lys Ser Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1074 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1074 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Tyr Gln Ala Ala Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1075 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1075 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Lys Ala Asn Leu Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1076 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1076 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Val Ile Met Gly Pro Glu Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1077 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1077 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ser Tyr Gly Ile Arg Leu Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1078 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1078 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Thr Gly Ala Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1079 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1079 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ala Arg Gly Val Lys Val Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1080 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1080 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Ser Ile Arg Ser Asp Met Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1081 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1081 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Ile Val Ile Leu Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1082 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1082 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Arg Ile Pro Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1083 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1083 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ala Trp Gly Val Lys Val Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1084 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1084 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Thr Lys Lys Thr Ala Val Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1085 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1085 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ile Met Leu Asn Gln Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1086 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1086 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Gly Leu Asn Tyr Val Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1087 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1087 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Leu His Ser Gly Pro Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1088 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1088 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Trp Lys Ser Gly Ala Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1089 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1089 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Trp Lys Ala Gln Lys Thr Ser Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1090 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1090 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg Thr Lys Gly Thr Ala Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1091 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1091 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Pro Arg His Ser Lys Val Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1092 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1092 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Gly Thr Ala Asn Val Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1093 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1093 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Leu Gly Asn Met Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1094 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1094 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Lys Val His Ile Glu Ile Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1095 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1095 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Glu Val Ser Cys Gly Pro Pro Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1096 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1096 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Lys Ala Lys Ala Gly Val Thr Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1097 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1097 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Ile Leu Asn Ala Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1098 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1098 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Arg Ser Val Asn Leu Thr Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1099 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1099 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Ser Tyr Glu Tyr Gly Ala Lys Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1100 <211> 518 <212> PRT <213> Artificial Sequence <220> <223> Dependoparvovirus adeno associated virus 5 capsid protein comprising artificial peptide sequence <400> 1100 Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 1 5 10 15 Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 20 25 30 Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 35 40 45 Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 50 55 60 Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 65 70 75 80 Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 85 90 95 Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 100 105 110 Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 115 120 125 Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 130 135 140 Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 145 150 155 160 Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 165 170 175 Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 180 185 190 Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 195 200 205 Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Ala Pro Leu Thr Asn 210 215 220 Thr Val Lys Ala Thr Gly Gly Val Gln Phe Asn Lys Asn Leu Ala Gly 225 230 235 240 Arg Tyr Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Gly Arg 245 250 255 Thr Gln Gly Trp Asn Leu Gly Ser Gly Val Asn Arg Ala Ser Val Ser 260 265 270 Ala Phe Ala Thr Thr Asn Arg Met Glu Leu Glu Gly Ala Ser Tyr Gln 275 280 285 Val Pro Pro Gln Pro Asn Gly Met Thr Asn Asn Leu Gln Gly Ser Asn 290 295 300 Thr Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ser Gln Pro Ala Asn 305 310 315 320 Pro Gly Thr Thr Ala Thr Tyr Leu Glu Gly Asn Met Leu Ile Thr Ser 325 330 335 Glu Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly 340 345 350 Gln Met Ala Thr Asn Asn Gln Ala Leu Lys Tyr Arg Gly Pro Pro Ala 355 360 365 Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile 370 375 380 Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro 385 390 395 400 Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro 405 410 415 Ala Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile 420 425 430 Lys Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro 435 440 445 Val Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu 450 455 460 Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 465 470 475 480 Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 485 490 495 Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 500 505 510 Tyr Leu Thr Arg Pro Leu 515 <210> 1101 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <220> <221> MISC_FEATURE <222> (1)..(1) <223> Xaa is Ala, Ser, Gly or may be absent <220> <221> misc_feature <222> (2)..(6) <223> Xaa can be any naturally occurring amino acid <220> <221> MISC_FEATURE <222> (7)..(10) <223> Xaa is any amino acid or may be absent <220> <221> MISC_FEATURE <222> (11)..(11) <223> Xaa is Ala, Ser, Gly or may be absent <400> 1101 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 <210> 1102 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <220> <221> MISC_FEATURE <222> (1)..(1) <223> Xaa is Ala, Ser, Gly or may be absent <220> <221> misc_feature <222> (2)..(8) <223> Xaa can be any naturally occurring amino acid <220> <221> MISC_FEATURE <222> (9)..(9) <223> Xaa is Ala, Ser, Gly or may be absent <400> 1102 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 <210> 1103 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa is Pro, Arg, or Gly <220> <221> MISC_FEATURE <222> (3)..(3) <223> Xaa is Lys, Leu, or Arg <220> <221> MISC_FEATURE <222> (4)..(4) <223> Xaa is any amino acid <220> <221> MISC_FEATURE <222> (5)..(5) <223> Xaa is Asn, His, Lys, or Gln <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa is any amino acid or Gly, Lys or Ser <220> <221> MISC_FEATURE <222> (7)..(7) <223> Xaa is any amino acid or Thr or Val <220> <221> MISC_FEATURE <222> (8)..(8) <223> Xaa is any amino acid or Lys or Val <400> 1103 Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala 1 5 <210> 1104 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa is Pro, Arg or Gly <220> <221> MISC_FEATURE <222> (3)..(3) <223> Xaa is Lys, Leu or Arg <220> <221> MISC_FEATURE <222> (4)..(4) <223> Xaa is any amino acid <220> <221> MISC_FEATURE <222> (5)..(5) <223> Xaa is Asn, His, Lys or Gln <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa is any amino acid or Gly, Lys or Ser <220> <221> MISC_FEATURE <222> (7)..(8) <223> Xaa is any amino acid <400> 1104 Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala 1 5 <210> 1105 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa is Pro, Arg or Gly <220> <221> MISC_FEATURE <222> (3)..(3) <223> Xaa is Lys, Leu or Arg <220> <221> MISC_FEATURE <222> (4)..(4) <223> Xaa is any amino acid <220> <221> MISC_FEATURE <222> (5)..(5) <223> Xaa is Asn, His, Lys, or Gln <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa is is any amino acid or Gly, Lys, or Ser <220> <221> MISC_FEATURE <222> (7)..(7) <223> Xaa is Thr or Val <220> <221> MISC_FEATURE <222> (8)..(8) <223> Xaa is any amino acid <400> 1105 Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala 1 5 <210> 1106 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa is Pro, Arg or Gly <220> <221> MISC_FEATURE <222> (3)..(3) <223> Xaa is Lys, Leu or Arg <220> <221> MISC_FEATURE <222> (4)..(4) <223> Xaa is any amino acid <220> <221> MISC_FEATURE <222> (5)..(5) <223> Xaa is Asn, His, Lys, or Gln <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa is any amino acid or Gly, Lys or Ser <220> <221> MISC_FEATURE <222> (7)..(7) <223> Xaa is Thr or Val <220> <221> MISC_FEATURE <222> (8)..(8) <223> Xaa is Lys or Val <400> 1106 Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala 1 5 <210> 1107 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Artificial peptide sequence <220> <221> MISC_FEATURE <222> (2)..(2) <223> Xaa is Pro, Arg or Gly <220> <221> MISC_FEATURE <222> (3)..(3) <223> Xaa is Lys, Leu or Arg <220> <221> MISC_FEATURE <222> (4)..(4) <223> Xaa is any amino acid <220> <221> MISC_FEATURE <222> (5)..(5) <223> Xaa is Asn, His, Lys, or Gln <220> <221> MISC_FEATURE <222> (6)..(6) <223> Xaa is Gly, Lys, or Ser <220> <221> MISC_FEATURE <222> (7)..(7) <223> Xaa is Thr or Val <220> <221> MISC_FEATURE <222> (8)..(8) <223> Xaa is Lys or Val <400> 1107 Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala 1 5

Claims (72)

  1. a) AAV5 캡시드 단백질(capsid protein)로서, 상기 캡시드 단백질은, 모(parental) AAV5 캡시드와 비교하여, S651A, S651G, S651V, S651L, S651I, T578A, T578G, T578V, T578L, T578I, T582A, T582G, T582V, T582L, 또는 T582I로부터 선택된 하나 이상의 치환을 포함하는, AAV5 캡시드 단백질; 및
    b) 유전자 산물을 암호화(encoding)하는 뉴클레오티드 서열을 포함하는 이종 핵산
    을 포함하는, 재조합 아데노-연관 바이러스(recombinant adeno-associated virus; rAAV) 비리온(virion).
  2. 제2항에 있어서, 상기 AAV5 캡시드 단백질이 S651A 또는 S651V; T578A 또는 T578V; 및/또는 T582A 또는 T582V로부터 선택된 2개 이상의 치환을 포함하는, rAAv 비리온.
  3. 제2항에 있어서, 상기 AAV5 캡시드 단백질이 T582A 및 S651A 치환을 포함하는, rAAV 비리온.
  4. 제3항에 있어서, 상기 AAV5 캡시드 단백질이 T578A 및 T582A 치환을 포함하는, rAAV 비리온.
  5. 제3항에 있어서, 상기 AAV5 캡시드 단백질이 T578A 및 S651A 치환을 포함하는, rAAV 비리온.
  6. 제3항에 있어서, 상기 AAV5 캡시드 단백질이 S651A, T578A 및 T582A 치환을 포함하는, rAAV 비리온.
  7. 제1항 내지 제6항 중 어느 한 항에 있어서, 상기 AAV5 캡시드 단백질이 서열번호 73에 대해 적어도 95% 동일성(identity), 적어도 98% 동일성, 또는 적어도 99% 동일성을 공유하는, rAAV 비리온.
  8. 모 AAV5 캡시드와 비교하여, S651A, S651G, S651V, S651L, S651I, T578A, T578G, T578V, T578L, T578I, T582A, T582G, T582V, T582L, 또는 T582I로부터 선택된 하나 이상의 치환을 포함하는, AAV5 캡시드 단백질.
  9. 제8항에 있어서, 상기 캡시드 단백질이 S651A 또는 S651V; T578A 또는 T578V; 또는 T582A 또는 T582V로부터 선택된 2개 이상의 치환을 포함하는, AAV5 캡시드 단백질.
  10. 제9항에 있어서, 상기 캡시드 단백질이 T582A 및 S651A 치환을 포함하는, AAV5 캡시드 단백질.
  11. 제9항에 있어서, 상기 캡시드 단백질이 T578A 및 T582A 치환을 포함하는, AAV5 캡시드 단백질.
  12. 제9항에 있어서, 상기 캡시드 단백질이 T578A 및 S651A 치환을 포함하는, AAV5 캡시드 단백질.
  13. 제9항에 있어서, 상기 캡시드 단백질이 S651A, T578A, 및 T582A 치환을 포함하는, AAV5 캡시드 단백질.
  14. 제8항 내지 제13항 중 어느 한 항에 있어서, 상기 캡시드 단백질이 서열번호 73에 대해 적어도 90% 동일성을 공유하는, AAV5 캡시드 단백질.
  15. 제8항 내지 제13항 중 어느 한 항에 있어서, 상기 캡시드 단백질이 서열번호 73에 대해 적어도 95% 동일성, 적어도 98% 동일성, 또는 적어도 99% 동일성을 공유하는, AAV5 캡시드 단백질.
  16. 제8항 내지 제15항 중 어느 한 항의 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드.
  17. 제1항 내지 제7항 중 어느 한 항의 rAAV 비리온을 포함하는, 약제학적 조성물.
  18. 심장 세포(cardiac cell)를 형질도입(transducing)하는 방법으로서,
    심장 세포를 제1항 내지 제7항 중 어느 한 항에 따른 rAAV 비리온과 접촉시키는 것을 포함하고, 여기서 상기 rAAV 비리온이 심장 세포를 형질도입하는, 방법.
  19. 하나 이상의 유전자 산물(gene product)을 심장 세포에 전달하는 방법으로서,
    심장 세포를 제1항 내지 제7항 중 어느 한 항에 따른 rAAV 비리온과 접촉시키는 것을 포함하고, 여기서 상기 심장 세포가 유전자 산물을 발현하는, 방법.
  20. 제18항 또는 제19항에 있어서, 상기 하나 이상의 유전자 산물이, 심장 트로포닌 T; 심장 근육 단백질; β-미오신 중쇄; 미오신 심실 필수 경쇄 1; 미오신 심실 조절 경쇄 2; 심장 α-액틴; α-트로포미오신; 심장 트로포닌 I; 심장 미오신 결합 단백질 C; 4.5 LIM 단백질 1; 티틴; 5'-AMP 활성화 단백질 키나제 서브유닛 감마-2; 트로포닌 I 유형 3, 미오신 경쇄 2, 액틴 알파 심장 근육 1; 심장 LIM 단백질; 카베올린 3(CAV3); 갈락토시다제 알파(GLA); 리소좀-관련 막 단백질 2(LAMP2); 미토콘드리아 전달 RNA 글리신(MTTG); 미토콘드리아 전달 RNA 이소류신(MTTI); 미토콘드리아 전달 RNA 라이신(MTTK); 미토콘드리아 전달 RNA 글루타민(MTTQ); 미오신 경쇄 3(MYL3); 트로포닌 C(TNNC1); 트랜스티레틴(TTR); 근소포체 칼슘-ATPase 2a(SERCA2a); 간질 유래 인자-1(SDF-1); 아데닐레이트 사이클라제-6(AC6); β-ARKct(β-아드레날린 수용체 키나제 C 말단); 섬유아세포 성장 인자(FGF); 혈소판 유래 성장 인자(PDGF); 혈관 내피 성장 인자(VEGF); 간세포 성장 인자; 저산소증 유도성 성장 인자; 티모신 베타 4(TMSB4X); 산화질소 신타제-3(NOS3); 아포리포단백질-E(ApoE); 및 슈퍼옥사이드 디스뮤타제(SOD); S100A1로부터 임의로 선택된, 폴리펩티드를 포함하는, 방법.
  21. 제18항 또는 제19항에 있어서, 하나 이상의 유전자 산물이 ASCL1, MYOCD, MEF2C, TBX5, CCNB1, CCND1, CDK1, CDK4, AURKB, OCT4, BAF60C, ESRRG, GATA4, GATA6, HAND2, IRX4, ISLL, MESP1, MESP2, NKX2.5, SRF, TBX20 및 ZFPM2로부터 임의로 선택된, 하나 이상의 재프로그래밍 인자(reprogramming factor)를 포함하는, 방법.
  22. 제21항에 있어서, 상기 방법이 심장 세포를 심장 심근세포로 재프로그래밍하는, 방법.
  23. 이를 필요로 하는 대상체에서 심장 병리(cardiac pathology)를 치료하는 방법으로서,
    치료학적 유효량의 제17항에 따른 약제학적 조성물을 상기 대상체에게 투여하는 것을 포함하고, 여기서 rAAV 비리온이 심장 조직을 형질도입하는, 방법.
  24. 제23항에 있어서, 상기 rAAV 비리온이 심외막 주사(epicardial injection)에 의해 투여되는, 방법.
  25. 제23항에 있어서, 상기 rAAV 비리온이 정맥내 주사, 근육내 주사, 복강내 주사, 심장내 주사, 심장내 카테터삽입(catheterization), 직접 심근내 주사, 혈관내 투여, 순행성 관상동맥 주사, 역행성 주사, 경심내막 주사(transendomyocardial injection), 또는 재순환 전달을 수반하는 분자 심장 수술(MCARD)에 의해 투여되는, 방법.
  26. a) AAV5 캡시드 단백질로서, 상기 캡시드 단백질이 모 서열의 GH 루프(loop)의 삽입 부위에서 5 내지 11개 아미노산의 모 서열에 대한 삽입을 포함하는, AAV5 캡시드 단백질; 및
    b) 유전자 산물을 암호화하는 뉴클레오티드 서열을 포함하는 이종 핵산
    을 포함하는, 재조합 아데노-연관 바이러스(rAAV) 비리온.
  27. 제26항에 있어서, 상기 삽입 부위가 서열번호 1의 560 내지 594에 대응하는 모 서열의 위치에서 임의의 2개의, 임의로 인접한 아미노산 사이에 있는, rAAV 비리온.
  28. 제27항에 있어서, 상기 삽입 부위가 서열번호 1의 574 및 575에 대응하는 모 서열 내의 인접한 아미노산 사이에 있는, rAAV 비리온.
  29. 제26항 내지 제28항 중 어느 한 항에 있어서, 상기 삽입이 하기 식의 펩티드인, rAAV 비리온:
    -X0-X1-X2-X3-X4-X5-X6-X7-X8-
    상기 식에서,
    X0 및 X8은 각각 독립적으로 A, S, G 또는 부재한다(서열번호 1102).
  30. 제29항에 있어서, 상기 삽입이 하기 식의 펩티드인, rAAV 비리온:
    -A-X1-X2-X3-X4-X5-X6-X7-A-
    상기 식에서,
    a) X1은 P, R 또는 G이고;
    b) X2는 K, L 또는 R이고;
    c) X3은 임의의 아미노산이고;
    d) X4는 N, H, K 또는 Q이고;
    e) X5는 임의의 아미노산이거나, 임의로 X5는 G, K 또는 S이고;
    f) X6은 임의의 아미노산이거나, 임의로 X6은 T 또는 V이고;
    g) X7은 임의의 아미노산이거나, 임의로 X7은 K 또는 V이다(서열번호 1103).
  31. 제30항에 있어서, 상기 삽입이 서열번호 101-600으로부터 선택된 아미노산 서열을 포함하는, rAAV 비리온.
  32. 제30항에 있어서, 상기 삽입이 RKVHIEV(서열번호 81), RKYQSDL(서열번호 82), PLTNTVK(서열번호 83), LKYHGPP(서열번호 84), RKYQGDM(서열번호 85), RKFHSTD(서열번호 86), RKHHGLE(서열번호 87), PGTNVTK(서열번호 88), RKMHMPD(서열번호 89), PLKKIVQ(서열번호 90), PLGKKTS(서열번호 91), PRGVKVT(서열번호 92), PLAKSKS(서열번호 93), PRTKGAV(서열번호 94) 및 PSGRKAT(서열번호 95)로부터 선택된 아미노산 서열을 포함하는, rAAV 비리온.
  33. 제30항에 있어서, 상기 삽입이 ARKVHIEVA(서열번호 101), ARKYQSDLA(서열번호 102), APLTNTVKA(서열번호 103), ALKYHGPPA(서열번호 104), ARKYQGDMA(서열번호 105), ARKFHSTDA(서열번호 106), ARKHHGLEA(서열번호 107), APGTNVTKA(서열번호 108), ARKMHMPDA(서열번호 109), APLKKIVQA(서열번호 110), APLGKKTSA(서열번호 111), APRGVKVTA(서열번호 112), APLAKSKSA(서열번호 113), APRTKGAVA(서열번호 114), APSGRKATA(서열번호 115)로부터 선택된 아미노산 서열을 포함하는, rAAV 비리온.
  34. 제30항에 있어서, 상기 삽입이 아미노산 서열 PLTNTVK(서열번호 83), 또는 PLTNTVK(서열번호 83)에 대해 최대 1, 2, 3, 또는 4개의 아미노산 치환을 포함하는 서열을 포함하는, rAAV 비리온.
  35. 제30항에 있어서, 상기 삽입이 아미노산 서열 PLKKIVQ(서열번호 90), 또는 PLKKIVQ(서열번호 90)에 대해 최대 1, 2, 3 또는 4개의 아미노산 치환을 포함하는 서열을 포함하는, rAAV 비리온.
  36. 제26항 내지 제35항 중 어느 한 항에 있어서, 상기 캡시드 단백질이, 모 AAV5 캡시드와 비교하여, S651A, T578A 또는 T582A로부터 선택된 하나 이상의 치환을 포함하는, rAAV 비리온.
  37. 제36항에 있어서, 상기 AAV5 캡시드 단백질이 S651A, T578A, 또는 T582A로부터 선택된 2개 이상의 치환을 포함하는, rAAV 비리온.
  38. 제36항에 있어서, 상기 AAV5 캡시드 단백질이 T582A 및 S651A 치환을 포함하는, rAAV 비리온.
  39. 제36항에 있어서, 상기 AAV5 캡시드 단백질이 T578A 및 T582A 치환을 포함하는, rAAV 비리온.
  40. 제36항에 있어서, 상기 AAV5 캡시드 단백질이 T578A 및 S651A 치환을 포함하는, rAAV 비리온.
  41. 제36항에 있어서, 상기 AAV5 캡시드 단백질이 S651A, T578A 및 T582A 치환을 포함하는, rAAV 비리온.
  42. 제26항 내지 제41항 중 어느 한 항에 있어서, 상기 rAAV 비리온이, 모 서열을 포함하는 AAV 비리온과 비교하여, 심장 세포에서 형질도입 효율의 증가를 나타내는, rAAV 비리온.
  43. 제26항 내지 제42항 중 어느 한 항에 있어서, 상기 rAAV 비리온이, 모 서열을 포함하는 AAV 비리온과 비교하여, 인간 심장 섬유아세포(hCF) 세포에서 형질도입 효율의 증가를 나타내는, rAAV 비리온.
  44. AAV5 캡시드 단백질로서,
    상기 캡시드 단백질이, 모 서열의 GH 루프 내의 삽입 부위에서 5 내지 11개 아미노산의 모 서열에 대한 삽입을 포함하는, AAV5 캡시드 단백질.
  45. 제44항에 있어서, 상기 삽입 부위가 서열번호 1의 574 및 575에 대응하는 모 서열 내의 인접한 아미노산 사이에 있는, AAV5 캡시드 단백질.
  46. 제44항 또는 제45항에 있어서, 상기 삽입이 하기 식의 펩티드인, AAV5 캡시드 단백질:
    -X0-(X)n-X10-
    상기 식에서,
    n은 5-9이고,
    X0 및 X10은 각각 독립적으로 A, S, G 또는 부재한다(서열번호 1101).
  47. 제44항 또는 제45항에 있어서, 상기 삽입이 하기 식의 펩티드인, AAV5 캡시드 단백질:
    -X0-X1-X2-X3-X4-X5-X6-X7-X8-
    상기 식에서,
    X0 및 X8은 각각 독립적으로 A, S, G 또는 부재한다(서열번호 1102).
  48. 제47항에 있어서, 상기 삽입이 하기 식의 펩티드인, AAV5 캡시드 단백질:
    -A-X1-X2-X3-X4-X5-X6-X7-A-
    상기 식에서,
    a) X1은 P, R 또는 G이고;
    b) X2는 K, L 또는 R이고;
    c) X3은 임의의 아미노산이고;
    d) X4는 N, H, K 또는 Q이고;
    e) X5는 임의의 아미노산이거나, 임의로 X5는 G, K 또는 S이고;
    f) X6은 임의의 아미노산이거나, 임의로 X6은 T 또는 V이고;
    g) X7은 임의의 아미노산이거나, 임의로 X7은 K 또는 V이다(서열번호 1103).
  49. 제48항에 있어서, 상기 삽입이 서열번호 101-600으로부터 선택된 아미노산 서열을 포함하는, AAV5 캡시드 단백질.
  50. 제48항에 있어서, 상기 삽입이 RKVHIEV(서열번호 81), RKYQSDL(서열번호 82), PLTNTVK(서열번호 83), LKYHGPP(서열번호 84), RKYQGDM(서열번호 85), RKFHSTD(서열번호 86), RKHHGLE(서열번호 87), PGTNVTK(서열번호 88), RKMHMPD(서열번호 89), PLKKIVQ(서열번호 90), PLGKKTS(서열번호 91), PRGVKVT(서열번호 92), PLAKSKS(서열번호 93), PRTKGAV(서열번호 94), 및 PSGRKAT(서열번호 95)로부터 선택된 아미노산 서열을 포함하는, AAV5 캡시드 단백질.
  51. 제48항에 있어서, 상기 삽입이 ARKVHIEVA(서열번호 101), ARKYQSDLA(서열번호 102), APLTNTVKA(서열번호 103), ALKYHGPPA(서열번호 104), ARKYQGDMA(서열번호 105), ARKFHSTDA(서열번호 106), ARKHHGLEA(서열번호 107), APGTNVTKA(서열번호 108), ARKMHMPDA(서열번호 109), APLKKIVQA(서열번호 110), APLGKKTSA(서열번호 111), APRGVKVTA(서열번호 112), APLAKSKSA(서열번호 113), APRTKGAVA(서열번호 114), APSGRKATA(서열번호 115)로부터 선택된 아미노산 서열을 포함하는, AAV5 캡시드 단백질.
  52. 제48항에 있어서, 상기 삽입이 아미노산 서열 PLTNTVK(서열번호 83), 또는 PLTNTVK(서열번호 83)에 대해 최대 1, 2, 3 또는 4개의 아미노산 치환을 포함하는 서열을 포함하는, AAV5 캡시드 단백질.
  53. 제48항에 있어서, 상기 삽입이 아미노산 서열 PLKKIVQ(서열번호 90), 또는 PLKKIVQ(서열번호 90)에 대해 최대 1, 2, 3 또는 4개의 아미노산 치환을 포함하는 서열을 포함하는, AAV5 캡시드 단백질.
  54. 제44항 내지 제53항 중 어느 한 항에 있어서, 상기 캡시드 단백질이, 모 AAV5 캡시드와 비교하여, S651A, T578A, 또는 T582A로부터 선택된 하나 이상의 치환을 포함하는, AAV5 캡시드 단백질.
  55. 제54항에 있어서, 상기 AAV5 캡시드 단백질이 S651A, T578A 또는 T582A로부터 선택된 2개 이상의 치환을 포함하는, AAV5 캡시드 단백질.
  56. 제44항 내지 제55항 중 어느 한 항의 AAV5 캡시드 단백질을 암호화하는 폴리뉴클레오티드.
  57. 제26항 내지 제43항 중 어느 한 항의 rAAV 비리온을 포함하는 약제학적 조성물.
  58. 심장 세포를 형질도입하는 방법으로서,
    심장 세포를 제26항 내지 제43항 중 어느 한 항에 따른 rAAV 비리온과 접촉시키는 것을 포함하고, 여기서 상기 rAAV 비리온이 심장 세포를 형질도입하는, 방법.
  59. 하나 이상의 유전자 산물을 심장 세포에 전달하는 방법으로서,
    심장 세포를 제26항 내지 제43항 중 어느 한 항에 따른 rAAV 비리온과 접촉시키는 것을 포함하고, 여기서 상기 심장 세포가 유전자 산물을 발현하는, 방법.
  60. 제58항 또는 제59항에 있어서, 상기 하나 이상의 유전자 산물이, 심장 트로포닌 T; 심장 근육 단백질; β-미오신 중쇄; 미오신 심실 필수 경쇄 1; 미오신 심실 조절 경쇄 2; 심장 α-액틴; α-트로포미오신; 심장 트로포닌 I; 심장 미오신 결합 단백질 C; 4.5 LIM 단백질 1; 티틴; 5'-AMP 활성화 단백질 키나제 서브유닛 감마-2; 트로포닌 I 유형 3, 미오신 경쇄 2, 액틴 알파 심장 근육 1; 심장 LIM 단백질; 카베올린 3(CAV3); 갈락토시다제 알파(GLA); 리소좀-관련 막 단백질 2(LAMP2); 미토콘드리아 전달 RNA 글리신(MTTG); 미토콘드리아 전달 RNA 이소류신(MTTI); 미토콘드리아 전달 RNA 라이신(MTTK); 미토콘드리아 전달 RNA 글루타민(MTTQ); 미오신 경쇄 3(MYL3); 트로포닌 C(TNNC1); 트랜스티레틴(TTR); 근소포체 칼슘-ATPase 2a(SERCA2a); 간질 유래 인자-1(SDF-1); 아데닐레이트 사이클라제-6(AC6); β-ARKct(β-아드레날린 수용체 키나제 C 말단); 섬유아세포 성장 인자(FGF); 혈소판 유래 성장 인자(PDGF); 혈관 내피 성장 인자(VEGF); 간세포 성장 인자; 저산소증 유도성 성장 인자; 티모신 베타 4(TMSB4X); 산화질소 신타제-3(NOS3); 아포리포단백질-E(ApoE); 및 슈퍼옥사이드 디스뮤타제(SOD); S100A1로부터 임의로 선택된, 폴리펩티드를 포함하는, 방법.
  61. 제58항 또는 제59항에 있어서, 상기 하나 이상의 유전자 산물이, ASCL1, MYOCD, MEF2C, TBX5, CCNB1, CCND1, CDK1, CDK4, AURKB, OCT4, BAF60C, ESRRG, GATA4, GATA6, HAND2, IRX4, ISLL, MESP1, MESP2, NKX2.5, SRF, TBX20 및 ZFPM2로부터 임의로 선택된, 하나 이상의 재프로그래밍 인자를 포함하는, 방법.
  62. 제61항에 있어서, 상기 방법이 심장 세포를 심장 심근세포로 재프로그래밍하는, 방법.
  63. 이를 필요로 하는 대상체(subject)에서 심장 병리를 치료하는 방법으로서,
    치료학적 유효량의 제57항에 따른 약제학적 조성물을 대상체에게 투여하는 것을 포함하고, 상기 rAAV 비리온이 심장 조직을 형질도입하는, 방법.
  64. 제63항에 있어서, 상기 rAAV 비리온이 심외막 주사에 의해 투여되는, 방법.
  65. 제63항에 있어서, 상기 rAAV 비리온이 정맥내 주사, 근육내 주사, 복강내 주사, 심장내 주사, 심장내 카테터삽입, 직접 심근내 주사, 혈관내 투여, 순행성 관상동맥 주사, 역행성 주사, 경심내막 주사, 또는 재순환 전달을 수반하는 분자 심장 수술(MCARD)에 의해 투여되는, 방법.
  66. 표적 세포에서 형질도입 효율의 증가를 rAAV 비리온에 부여하는 AAV 캡시드 단백질을 동정(identifying)하는 방법으로서,
    a) rAAV 게놈이 변이체 AAV 캡시드 단백질을 암호화하는 cap 폴리뉴클레오티드의 라이브러리를 포함하는 rAAV 비리온의 집단(population)을 제공하는 단계;
    b) rAAV 비리온에 의해 표적 세포 내로 cap 폴리뉴클레오티드의 형질도입을 허용하기에 충분한 시간 동안 집단을 표적 세포와 접촉시키는 단계; 및
    c) 표적 세포로부터 cap 폴리뉴클레오티드를 서열분석(sequencing)함으로써 표적 세포에서 형질도입 효율의 증가를 부여하는 AAV 캡시드 단백질을 동정하는 단계
    를 포함하는, 방법.
  67. 제66항에 있어서, 단계 (b) 전에, 비표적 세포(non-target cell)에 rAAV 비리온의 부착을 허용하기에 충분한 시간 동안 집단을 비표적 세포와 접촉시킴으로써 rAAV 비리온의 집단을 고갈시키는 단계를 추가로 포함하는, 방법.
  68. 제66항 또는 제67항에 있어서, 상기 변이체 AAV 캡시드 단백질이 AAV5 캡시드 단백질인, 방법.
  69. 제66항 내지 제68항 중 어느 한 항에 있어서, 상기 변이체 캡시드 단백질이 각각 개별적으로 모 서열의 GH 루프 내의 삽입 부위에서 5 내지 11개 아미노산의 모 서열에 대한 삽입을 포함하는, 방법.
  70. 제69항에 있어서, 상기 삽입 부위가 서열번호 1의 560 내지 594에 대응하는 모 서열의 위치에서 임의의 2개의, 임의로 인접한 아미노산 사이에 있는, 방법.
  71. 제69항에 있어서, 상기 삽입 부위가 서열번호 1의 574 및 575에 대응하는 모 서열의 인접한 아미노산 사이에 있는, 방법.
  72. 제69항 내지 제71항 중 어느 한 항에 있어서, 상기 삽입이 하기 식의 펩티드인, 방법:
    -X0-X1-X2-X3-X4-X5-X6-X7-X8-
    상기 식에서,
    X0 및 X8은 각각 독립적으로 A, S, G 또는 부재한다(서열번호 1102).
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WO2023200742A2 (en) 2022-04-11 2023-10-19 Tenaya Therapeutics, Inc. Capsids for plakophillin-2 gene therapy

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