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ES2119743T3 - Conjugados de colageno y polimero. - Google Patents

Conjugados de colageno y polimero.

Info

Publication number
ES2119743T3
ES2119743T3 ES90901254T ES90901254T ES2119743T3 ES 2119743 T3 ES2119743 T3 ES 2119743T3 ES 90901254 T ES90901254 T ES 90901254T ES 90901254 T ES90901254 T ES 90901254T ES 2119743 T3 ES2119743 T3 ES 2119743T3
Authority
ES
Spain
Prior art keywords
collagen
type
conjugates
fibrillar
dehydrated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90901254T
Other languages
English (en)
Inventor
Woonza Rhee
Donald G Wallace
Alan S Michaels
Ramon A Burns Jr
Louis Fries
Frank Delustro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Angiotech Biomaterials Corp
Original Assignee
Cohesion Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cohesion Technologies Inc filed Critical Cohesion Technologies Inc
Application granted granted Critical
Publication of ES2119743T3 publication Critical patent/ES2119743T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C08L89/06Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00365Proteins; Polypeptides; Degradation products thereof
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    • AHUMAN NECESSITIES
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • A61L2300/414Growth factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/426Immunomodulating agents, i.e. cytokines, interleukins, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62Encapsulated active agents, e.g. emulsified droplets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/16Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2666/00Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
    • C08L2666/02Organic macromolecular compounds, natural resins, waxes or and bituminous materials
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/937Utility as body contact e.g. implant, contact lens or I.U.D.

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Abstract

EL COLAGENO, ESPECIALMENTE EL COLAGENO ATELOPEPTIDO, MUESTRA MEJORADAS CARACTERISTICAS DE MANEJO CUANDO SE CONJUGA QUIMICAMENTE Y/O SE ENLAZA EN CRUZ CON UN POLIMERO HIDROFILICO SINTETICO.
ES90901254T 1988-11-21 1989-11-21 Conjugados de colageno y polimero. Expired - Lifetime ES2119743T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27407188A 1988-11-21 1988-11-21
US07/433,441 US5162430A (en) 1988-11-21 1989-11-14 Collagen-polymer conjugates

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ES2119743T3 true ES2119743T3 (es) 1998-10-16

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ES90901254T Expired - Lifetime ES2119743T3 (es) 1988-11-21 1989-11-21 Conjugados de colageno y polimero.

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US (8) US5162430A (es)
EP (1) EP0444157B1 (es)
JP (1) JP2505312B2 (es)
AT (1) ATE168708T1 (es)
AU (1) AU638687B2 (es)
CA (1) CA2003538C (es)
DE (1) DE68928754T2 (es)
ES (1) ES2119743T3 (es)
WO (1) WO1990005755A1 (es)

Families Citing this family (803)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10237531A1 (de) * 2002-08-16 2004-02-26 Tutogen Medical Gmbh Implantat
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5614587A (en) * 1988-11-21 1997-03-25 Collagen Corporation Collagen-based bioadhesive compositions
US5936035A (en) * 1988-11-21 1999-08-10 Cohesion Technologies, Inc. Biocompatible adhesive compositions
US5306500A (en) * 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5527856A (en) * 1988-11-21 1996-06-18 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5800541A (en) * 1988-11-21 1998-09-01 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
US5565519A (en) * 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US5475052A (en) * 1988-11-21 1995-12-12 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5643464A (en) 1988-11-21 1997-07-01 Collagen Corporation Process for preparing a sterile, dry crosslinking agent
US5550187A (en) * 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5006330A (en) * 1988-11-30 1991-04-09 The United States Of America As Represented By The Of The Department Of Health And Human Services Evaluative means for detecting inflammatory reactivity
DE59010941D1 (de) * 1989-04-21 2005-03-24 Amgen Inc TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs
US7264944B1 (en) 1989-04-21 2007-09-04 Amgen Inc. TNF receptors, TNF binding proteins and DNAs coding for them
US6143866A (en) * 1989-07-18 2000-11-07 Amgen, Inc. Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
IL95031A (en) 1989-07-18 2007-03-08 Amgen Inc Method for the production of a human recombinant tumor necrosis factor inhibitor
SG49267A1 (en) * 1989-08-14 1998-05-18 Photogenesis Inc Surgical instrument and cell isolation and transplantation
US5817075A (en) * 1989-08-14 1998-10-06 Photogenesis, Inc. Method for preparation and transplantation of planar implants and surgical instrument therefor
US6514238B1 (en) 1989-08-14 2003-02-04 Photogenesis, Inc. Method for preparation and transplantation of volute grafts and surgical instrument therefor
US5422340A (en) * 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
US5125888A (en) * 1990-01-10 1992-06-30 University Of Virginia Alumni Patents Foundation Magnetic stereotactic system for treatment delivery
EP0443809A3 (en) * 1990-02-20 1992-04-15 Ioptex Research Inc. Coated intraocular lens and coatings therefor
US5201764A (en) * 1990-02-28 1993-04-13 Autogenesis Technologies, Inc. Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US5833665A (en) * 1990-06-14 1998-11-10 Integra Lifesciences I, Ltd. Polyurethane-biopolymer composite
CA2085255C (en) * 1990-06-14 2001-10-09 Matthew Bootman Polyurethane-biopolymer composite
US6990982B1 (en) 1990-06-28 2006-01-31 Bonutti Ip, Llc Method for harvesting and processing cells from tissue fragments
US5269785A (en) * 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
AU652022B2 (en) * 1991-02-12 1994-08-11 C.R. Bard Inc. Injectable medical device
CA2081104A1 (en) * 1991-02-22 1992-08-23 Glenn Pierce Use of gm-csf and g-csf to promote accelerated wound healing
ATE180681T1 (de) * 1991-03-29 1999-06-15 Vascular Graft Research Center Künstliches blutgefäss aus komposit-material
CA2102808A1 (en) 1991-05-10 1992-11-11 Hanne Bentz Targeted delivery of bone growth factors
CA2071137A1 (en) * 1991-07-10 1993-01-11 Clarence C. Lee Composition and method for revitalizing scar tissue
US6503277B2 (en) * 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US20080070842A1 (en) * 1991-11-04 2008-03-20 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
JP3504263B2 (ja) * 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
IT1260468B (it) * 1992-01-29 1996-04-09 Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
US7060287B1 (en) * 1992-02-11 2006-06-13 Bioform Inc. Tissue augmentation material and method
US7968110B2 (en) * 1992-02-11 2011-06-28 Merz Aesthetics, Inc. Tissue augmentation material and method
WO1993017669A1 (en) 1992-02-28 1993-09-16 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
EP0627927A1 (en) * 1992-02-28 1994-12-14 Jsf Consultants Ltd. Use of injectable biomaterials in the treatment of hemorrhoids
US5480644A (en) * 1992-02-28 1996-01-02 Jsf Consultants Ltd. Use of injectable biomaterials for the repair and augmentation of the anal sphincters
US6045791A (en) * 1992-03-06 2000-04-04 Photogenesis, Inc. Retinal pigment epithelium transplantation
US6350274B1 (en) 1992-05-11 2002-02-26 Regen Biologics, Inc. Soft tissue closure systems
US5326350A (en) * 1992-05-11 1994-07-05 Li Shu Tung Soft tissue closure systems
EP1338648B1 (en) * 1992-05-29 2005-11-30 The University Of North Carolina At Chapel Hill Pharmaceutically acceptable fixed-dried human blood platelets
EP0648239A4 (en) * 1992-07-02 1995-09-27 Collagen Corp BIOCOMPATIBLE POLYMERIC CONJUGATES.
US6592859B1 (en) * 1992-08-20 2003-07-15 Ethicon, Inc. Controlled expansion sphincter augmentation media
US5836313A (en) * 1993-02-08 1998-11-17 Massachusetts Institute Of Technology Methods for making composite hydrogels for corneal prostheses
US6576008B2 (en) 1993-02-19 2003-06-10 Scimed Life Systems, Inc. Methods and device for inserting and withdrawing a two piece stent across a constricting anatomic structure
FR2701648B1 (fr) * 1993-02-19 1995-03-31 Marian Devonec Prothèse destinée au traitement d'une lumière ou voie naturelle, notamment prothèse endo-uréthrale.
CA2121192A1 (en) * 1993-04-21 1994-10-22 Kiminori Atsumi Collagen membranes
AU6586394A (en) * 1993-04-22 1994-11-08 Celtrix Pharmaceuticals, Inc. Conjugates of growth factor and bone resorption inhibitor
US5876454A (en) * 1993-05-10 1999-03-02 Universite De Montreal Modified implant with bioactive conjugates on its surface for improved integration
US5449720A (en) * 1993-05-24 1995-09-12 Biotech Australia Pty Limited Amplification of the VB12 uptake system using polymers
US5548064A (en) * 1993-05-24 1996-08-20 Biotech Australia Pty Limited Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions
JP3639593B2 (ja) * 1993-05-31 2005-04-20 科研製薬株式会社 塩基性線維芽細胞増殖因子含有架橋ゼラチンゲル製剤
US5531791A (en) * 1993-07-23 1996-07-02 Bioscience Consultants Composition for repair of defects in osseous tissues, method of making, and prosthesis
EP0637450A3 (en) * 1993-08-04 1995-04-05 Collagen Corp Method and composition for resuscitation of hereditary tissue.
WO1995005846A1 (en) * 1993-08-26 1995-03-02 Genetics Institute, Inc. Neural regeneration using human bone morphogenetic proteins
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US5446090A (en) * 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
PT733109E (pt) 1993-12-07 2006-07-31 Genetics Inst Llc Proteinas morfogeneticas dos 0ss0s pmo-12 e pmo-13 e as suas composicoes para inducao de tendao
FR2715309B1 (fr) * 1994-01-24 1996-08-02 Imedex Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé.
US5656605A (en) * 1994-01-26 1997-08-12 Institute Of Molecular Biology, Inc. Device to promote drug-induced nerve regeneration
CA2140053C (en) * 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US6074840A (en) * 1994-02-18 2000-06-13 The Regents Of The University Of Michigan Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US20020193338A1 (en) * 1994-02-18 2002-12-19 Goldstein Steven A. In vivo gene transfer methods for wound healing
US5962427A (en) * 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US6551618B2 (en) * 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
EP0751751A4 (en) * 1994-03-22 1998-03-25 Organogenesis Inc THREE-DIMENSIONAL BIOREMODELABLE COLLAGEN
US20050245850A1 (en) * 1994-03-30 2005-11-03 Freyre Carlos V Method and apparatus for inhibiting the growth of and shrinking cancerous tumors
US6500112B1 (en) 1994-03-30 2002-12-31 Brava, Llc Vacuum dome with supporting rim and rim cushion
US6001123A (en) * 1994-04-01 1999-12-14 Gore Enterprise Holdings Inc. Folding self-expandable intravascular stent-graft
US6165210A (en) * 1994-04-01 2000-12-26 Gore Enterprise Holdings, Inc. Self-expandable helical intravascular stent and stent-graft
WO1995026761A1 (en) * 1994-04-04 1995-10-12 Collagen Corporation Cell-gels
US5693085A (en) 1994-04-29 1997-12-02 Scimed Life Systems, Inc. Stent with collagen
US5629384A (en) * 1994-05-17 1997-05-13 Consiglio Nazionale Delle Ricerche Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
US5616689A (en) * 1994-07-13 1997-04-01 Collagen Corporation Method of controlling structure stability of collagen fibers produced form solutions or dispersions treated with sodium hydroxide for infectious agent deactivation
US6713662B1 (en) * 1994-07-27 2004-03-30 Pharming Intellectual Property B.V. Production of collagen in the milk of transgenic mammals
US5583114A (en) * 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
USRE38827E1 (en) 1994-07-27 2005-10-11 3M Innovative Properties Company Adhesive sealant composition
US6331188B1 (en) 1994-08-31 2001-12-18 Gore Enterprise Holdings, Inc. Exterior supported self-expanding stent-graft
US6015429A (en) * 1994-09-08 2000-01-18 Gore Enterprise Holdings, Inc. Procedures for introducing stents and stent-grafts
JP3699141B2 (ja) * 1994-09-24 2005-09-28 伸彦 由井 超分子構造の生体内分解性医薬高分子集合体及びその調製方法
AU1287895A (en) * 1994-10-03 1996-04-26 Otogen Corporation Differentially biodegradable biomedical implants
US5738846A (en) * 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
EP0713707A1 (en) 1994-11-23 1996-05-29 Collagen Corporation In situ crosslinkable, injectable collagen composition for tissue augmention
US5588960A (en) * 1994-12-01 1996-12-31 Vidamed, Inc. Transurethral needle delivery device with cystoscope and method for treatment of urinary incontinence
US5518732A (en) * 1995-02-14 1996-05-21 Chiron Vision, Inc. Bio-erodible ophthalmic shield
GB9503492D0 (en) 1995-02-22 1995-04-12 Ed Geistlich S Hne A G F R Che Chemical product
US20050186673A1 (en) * 1995-02-22 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
US5868728A (en) * 1995-02-28 1999-02-09 Photogenesis, Inc. Medical linear actuator for surgical delivery, manipulation, and extraction
US6962979B1 (en) * 1995-03-14 2005-11-08 Cohesion Technologies, Inc. Crosslinkable biomaterial compositions containing hydrophobic and hydrophilic crosslinking agents
CA2165728A1 (en) * 1995-03-14 1996-09-15 Woonza M. Rhee Use of hydrophobic crosslinking agents to prepare crosslinked biomaterial compositions
US5580923A (en) * 1995-03-14 1996-12-03 Collagen Corporation Anti-adhesion films and compositions for medical use
US5674290A (en) * 1995-04-05 1997-10-07 Li; Shu-Tung Water-stabilized biopolymeric implants
DE19514087A1 (de) * 1995-04-13 1996-10-17 Deutsches Krebsforsch Konjugat aus einem Wirkstoff, einem Polyether und ggfs. einem nicht als körperfremd angesehenen, nativen Protein
US5676967A (en) * 1995-04-18 1997-10-14 Brennen Medical, Inc. Mesh matrix wound dressing
US6120536A (en) * 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US6099562A (en) * 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US20020091433A1 (en) * 1995-04-19 2002-07-11 Ni Ding Drug release coated stent
US6083912A (en) * 1995-05-01 2000-07-04 Roger K. Khouri Method for soft tissue augmentation
WO1996039125A1 (en) * 1995-06-06 1996-12-12 University Of Nebraska Board Of Regents Composition and method for administration of bio-affecting catalysts
US6214331B1 (en) 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
AU7398196A (en) * 1995-10-11 1997-04-30 Fusion Medical Technologies, Inc. Device and method for sealing tissue
US6902584B2 (en) 1995-10-16 2005-06-07 Depuy Spine, Inc. Bone grafting matrix
US5776193A (en) * 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
JPH09143093A (ja) * 1995-11-17 1997-06-03 Hoechst Japan Ltd 軟骨・骨誘導性修復用材料
CN1052915C (zh) * 1995-11-27 2000-05-31 中国医学科学院生物医学工程研究所 用于携载基因的蛋白质涂层医用载体及其制作方法
US5863984A (en) * 1995-12-01 1999-01-26 Universite Laval, Cite Universitaire Biostable porous material comprising composite biopolymers
US6042605A (en) 1995-12-14 2000-03-28 Gore Enterprose Holdings, Inc. Kink resistant stent-graft
AU1413797A (en) 1995-12-14 1997-07-03 Prograft Medical, Inc. Stent-graft deployment apparatus and method
US7883693B2 (en) 1995-12-18 2011-02-08 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US6833408B2 (en) 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
ES2373200T3 (es) 1995-12-18 2012-02-01 Angiodevice International Gmbh Composiciones de pol�?meros reticulados y métodos para su uso.
CA2197375C (en) * 1996-02-15 2003-05-06 Yasuhiro Okuda Artificial blood vessel
SE9601243D0 (sv) * 1996-03-29 1996-03-29 Hans Arne Hansson Promotion of regeneration of organized tissues
US6416774B1 (en) 1996-05-09 2002-07-09 The Trustees Of The University Of Pennsyvania Hollow bone mineral-like calcium phosphate particles
US6224913B1 (en) 1996-05-09 2001-05-01 The Trustees Of The University Of Pennsylvania Conditioning of bioactive glass surfaces in protein containing solutions
US5940807A (en) * 1996-05-24 1999-08-17 Purcell; Daniel S. Automated and independently accessible inventory information exchange system
US5718012A (en) * 1996-05-28 1998-02-17 Organogenesis, Inc. Method of strength enhancement of collagen constructs
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
US5855615A (en) * 1996-06-07 1999-01-05 Menlo Care, Inc. Controller expansion sphincter augmentation media
US6143037A (en) * 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US5792478A (en) * 1996-07-08 1998-08-11 Advanced Uro Science Tissue injectable composition and method of use
TW555765B (en) * 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
US5852127A (en) * 1996-07-09 1998-12-22 Rensselner Polytechnic Institute Modification of porous and non-porous materials using self-assembled monolayers
DE69709501D1 (de) * 1996-07-29 2002-02-14 Loders Croklaan Bv Kollagenmischung
EP0821878B1 (en) * 1996-07-29 2002-01-09 Loders Croklaan B.V. Collagen blend
US5813411A (en) * 1996-08-20 1998-09-29 Menlo Care, Inc. Method of deforming tissue with a swollen hydrogel
US7049346B1 (en) 1996-08-20 2006-05-23 Menlo Care Div Of Ethicon, Inc. Swollen hydrogel for sphincter augmentation
DK1378257T3 (da) * 1996-08-23 2008-08-25 Cook Biotech Inc Colagen-baseret transplantatprotese
US6666892B2 (en) * 1996-08-23 2003-12-23 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
US8716227B2 (en) 1996-08-23 2014-05-06 Cook Biotech Incorporated Graft prosthesis, materials and methods
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US5989269A (en) 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US6569172B2 (en) 1996-08-30 2003-05-27 Verigen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
AU4648697A (en) * 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US7009034B2 (en) * 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US20090324721A1 (en) 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
US5856308A (en) * 1996-09-27 1999-01-05 Haemacure Corporation Artificial collagen
US6072040A (en) 1996-10-15 2000-06-06 Medical Analysis Systems, Inc. Stabilized conjugates of uncomplexed subunits of multimeric proteins
US6387700B1 (en) * 1996-11-04 2002-05-14 The Reagents Of The University Of Michigan Cationic peptides, Cys-Trp-(LYS)n, for gene delivery
US5980972A (en) * 1996-12-20 1999-11-09 Schneider (Usa) Inc Method of applying drug-release coatings
US6352561B1 (en) 1996-12-23 2002-03-05 W. L. Gore & Associates Implant deployment apparatus
US6551350B1 (en) 1996-12-23 2003-04-22 Gore Enterprise Holdings, Inc. Kink resistant bifurcated prosthesis
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
US8083745B2 (en) 2001-05-25 2011-12-27 Conformis, Inc. Surgical tools for arthroplasty
US10085839B2 (en) 2004-01-05 2018-10-02 Conformis, Inc. Patient-specific and patient-engineered orthopedic implants
US8771365B2 (en) 2009-02-25 2014-07-08 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs, and related tools
US7534263B2 (en) 2001-05-25 2009-05-19 Conformis, Inc. Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty
US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US9603711B2 (en) 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
WO1998030141A2 (en) 1997-01-09 1998-07-16 Cohesion Technologies, Inc. Devices for tissue repair and methods for preparation and use thereof
US5925061A (en) * 1997-01-13 1999-07-20 Gore Enterprise Holdings, Inc. Low profile vascular stent
ATE342729T1 (de) * 1997-01-15 2006-11-15 Phoenix Pharmacologics Inc Modifizierter tumor-nekrosefaktor
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
DK0984795T3 (da) * 1997-04-22 2004-02-02 Washington Res Found Knogletransplantater og proteser coated med tartratresistent sur phosphatase
US6149581A (en) * 1997-06-12 2000-11-21 Klingenstein; Ralph James Device and method for access to the colon and small bowel of a patient
US7192984B2 (en) * 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
US6300127B1 (en) 1997-07-30 2001-10-09 Emory University Bone mineralization proteins, DNA, vectors, expression systems
US6166184A (en) * 1997-08-18 2000-12-26 Medtronic Inc. Process for making a bioprosthetic device
US6117979A (en) * 1997-08-18 2000-09-12 Medtronic, Inc. Process for making a bioprosthetic device and implants produced therefrom
US6342250B1 (en) 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
GB2329840C (en) * 1997-10-03 2007-10-05 Johnson & Johnson Medical Biopolymer sponge tubes
US20050186283A1 (en) * 1997-10-10 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
US8858981B2 (en) * 1997-10-10 2014-10-14 Ed. Geistlich Soehne Fuer Chemistrie Industrie Bone healing material comprising matrix carrying bone-forming cells
US9034315B2 (en) * 1997-10-10 2015-05-19 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Cell-charged multi-layer collagen membrane
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US7637948B2 (en) * 1997-10-10 2009-12-29 Senorx, Inc. Tissue marking implant
US20030180263A1 (en) * 2002-02-21 2003-09-25 Peter Geistlich Resorbable extracellular matrix for reconstruction of bone
US6511468B1 (en) 1997-10-17 2003-01-28 Micro Therapeutics, Inc. Device and method for controlling injection of liquid embolic composition
US6458095B1 (en) 1997-10-22 2002-10-01 3M Innovative Properties Company Dispenser for an adhesive tissue sealant having a housing with multiple cavities
FI974321A0 (fi) * 1997-11-25 1997-11-25 Jenny Ja Antti Wihurin Rahasto Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa
US6660301B1 (en) * 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
CA2322954C (en) * 1998-03-06 2011-06-07 Biosepra Inc. Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles
EP1061954B1 (en) 1998-03-12 2004-06-09 Nektar Therapeutics Al, Corporation Poly(ethylene glycol) derivatives with proximal reactive groups
US6161034A (en) * 1999-02-02 2000-12-12 Senorx, Inc. Methods and chemical preparations for time-limited marking of biopsy sites
EP1071445A2 (en) * 1998-04-17 2001-01-31 Angiogenix, Incorporated Therapeutic angiogenic factors and methods for their use
US6395253B2 (en) 1998-04-23 2002-05-28 The Regents Of The University Of Michigan Microspheres containing condensed polyanionic bioactive agents and methods for their production
US6428978B1 (en) * 1998-05-08 2002-08-06 Cohesion Technologies, Inc. Methods for the production of gelatin and full-length triple helical collagen in recombinant cells
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
US20020022588A1 (en) * 1998-06-23 2002-02-21 James Wilkie Methods and compositions for sealing tissue leaks
EP1094829B8 (en) 1998-07-13 2004-09-22 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US6916783B2 (en) * 1998-07-13 2005-07-12 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US20020015724A1 (en) * 1998-08-10 2002-02-07 Chunlin Yang Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing
WO2000009018A1 (en) * 1998-08-10 2000-02-24 Fibrogen, Inc. Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
KR20040081798A (ko) 1998-08-14 2004-09-22 페리겐 트란스플란타치온 서비스 인터나치오날 (파우테에스이) 아게 연골세포 이식을 위한 방법, 기구 및 물질
DE69941304D1 (de) 1998-09-14 2009-10-01 Univ R Zustandsbestimmung eines gelenks und schadenvorsorge
US7239908B1 (en) 1998-09-14 2007-07-03 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US20030007991A1 (en) * 1998-09-25 2003-01-09 Masters David B. Devices including protein matrix materials and methods of making and using thereof
US20050147690A1 (en) * 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US7067144B2 (en) * 1998-10-20 2006-06-27 Omeros Corporation Compositions and methods for systemic inhibition of cartilage degradation
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US6110484A (en) * 1998-11-24 2000-08-29 Cohesion Technologies, Inc. Collagen-polymer matrices with differential biodegradability
US8882850B2 (en) * 1998-12-01 2014-11-11 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
US6478656B1 (en) 1998-12-01 2002-11-12 Brava, Llc Method and apparatus for expanding soft tissue with shape memory alloys
EP1051116B8 (en) * 1998-12-01 2009-06-10 Washington University Embolization device
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
CA2353642C (en) * 1998-12-04 2009-11-10 Amarpreet S. Sawhney Biocompatible crosslinked polymers
US6454787B1 (en) 1998-12-11 2002-09-24 C. R. Bard, Inc. Collagen hemostatic foam
US6361551B1 (en) 1998-12-11 2002-03-26 C. R. Bard, Inc. Collagen hemostatic fibers
US6371904B1 (en) 1998-12-24 2002-04-16 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US6356782B1 (en) 1998-12-24 2002-03-12 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US9669113B1 (en) 1998-12-24 2017-06-06 Devicor Medical Products, Inc. Device and method for safe location and marking of a biopsy cavity
US20020065546A1 (en) * 1998-12-31 2002-05-30 Machan Lindsay S. Stent grafts with bioactive coatings
US20050171594A1 (en) * 1998-12-31 2005-08-04 Angiotech International Ag Stent grafts with bioactive coatings
AU2730600A (en) * 1999-01-22 2000-08-07 St. Jude Medical Inc. Medical adhesives
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
US7651505B2 (en) 2002-06-17 2010-01-26 Senorx, Inc. Plugged tip delivery for marker placement
US7983734B2 (en) 2003-05-23 2011-07-19 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US20090030309A1 (en) 2007-07-26 2009-01-29 Senorx, Inc. Deployment of polysaccharide markers
US8361082B2 (en) * 1999-02-02 2013-01-29 Senorx, Inc. Marker delivery device with releasable plug
US6725083B1 (en) 1999-02-02 2004-04-20 Senorx, Inc. Tissue site markers for in VIVO imaging
US6862470B2 (en) 1999-02-02 2005-03-01 Senorx, Inc. Cavity-filling biopsy site markers
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
US8498693B2 (en) 1999-02-02 2013-07-30 Senorx, Inc. Intracorporeal marker and marker delivery device
JP2002536386A (ja) * 1999-02-12 2002-10-29 コラジェネシス インク. 細胞または治療薬の送達のためのコラーゲンベースの注射システム
FR2790475B1 (fr) * 1999-03-02 2003-01-24 Flamel Tech Sa Peptides collageniques modifies par greffage de fonctions mercapto, l'un de leurs procedes d'obtention et leurs applications comme biomateriaux
AU760358B2 (en) 1999-04-16 2003-05-15 Wm. Marsh Rice University Functionalized poly(propylene fumarate) and poly(propylene fumarate-co-ethylene glycol)
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US6428576B1 (en) * 1999-04-16 2002-08-06 Endospine, Ltd. System for repairing inter-vertebral discs
US6858229B1 (en) * 1999-04-26 2005-02-22 California Institute Of Technology In situ forming hydrogels
US7015198B1 (en) 1999-05-11 2006-03-21 Orentreich Foundation For The Advancement Of Science, Inc. Materials for soft tissue augmentation and methods of making and using same
US6575991B1 (en) * 1999-06-17 2003-06-10 Inrad, Inc. Apparatus for the percutaneous marking of a lesion
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6770740B1 (en) 1999-07-13 2004-08-03 The Regents Of The University Of Michigan Crosslinked DNA condensate compositions and gene delivery methods
US6312421B1 (en) 1999-07-23 2001-11-06 Neurovasx, Inc. Aneurysm embolization material and device
US6162258A (en) * 1999-08-25 2000-12-19 Osteotech, Inc. Lyophilized monolithic bone implant and method for treating bone
DK2093245T3 (da) 1999-08-27 2012-06-04 Angiodevice Internat Gmbh Biocompatible polymer device
EP1212107B1 (en) * 1999-08-31 2005-06-08 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6371984B1 (en) 1999-09-13 2002-04-16 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US7189392B1 (en) * 1999-10-15 2007-03-13 Genetics Institute, Llc Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
EE9900442A (et) * 1999-11-29 2001-08-15 Tartu Ülikool Bioloogiliselt aktiivne materjal
CA2393595A1 (en) * 1999-12-10 2001-06-14 Gigi Chiu Lipid carrier compositions with protected surface reactive functions
US6623963B1 (en) 1999-12-20 2003-09-23 Verigen Ag Cellular matrix
US20030095993A1 (en) * 2000-01-28 2003-05-22 Hanne Bentz Gel-infused sponges for tissue repair and augmentation
DE60137489D1 (de) * 2000-02-03 2009-03-12 Tissuemed Ltd Gerät zum verschliessen einer chirurgischen punktionswunde
AU2001249221A1 (en) 2000-03-20 2001-10-03 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
US6436424B1 (en) * 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US7338657B2 (en) * 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
KR20080046750A (ko) 2000-03-24 2008-05-27 바이오스피어 메디칼 인코포레이티드 능동 색전화용 미소구
JP4074043B2 (ja) * 2000-03-27 2008-04-09 株式会社資生堂 皮膚基底膜形成促進剤、人工皮膚形成促進剤及び人工皮膚の製造方法
US6884778B2 (en) * 2000-04-14 2005-04-26 William Marsh Rice University Biocompatible macromers
US7300662B2 (en) 2000-05-12 2007-11-27 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US8236048B2 (en) * 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US6776796B2 (en) 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20040243097A1 (en) * 2000-05-12 2004-12-02 Robert Falotico Antiproliferative drug and delivery device
SG98393A1 (en) 2000-05-19 2003-09-19 Inst Materials Research & Eng Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
US7083644B1 (en) * 2000-05-24 2006-08-01 Scimed Life Systems, Inc. Implantable prostheses with improved mechanical and chemical properties
US6423332B1 (en) 2000-05-26 2002-07-23 Ethicon, Inc. Method and composition for deforming soft tissues
US20030032143A1 (en) * 2000-07-24 2003-02-13 Neff Thomas B. Collagen type I and type III compositions for use as an adhesive and sealant
US7635592B2 (en) * 2000-08-21 2009-12-22 Rice University Tissue engineering scaffolds promoting matrix protein production
US7726319B1 (en) 2000-08-24 2010-06-01 Osteotech, Inc. Method for removal of water associated with bone while diminishing the dimensional changes associated with lyophilization
AU2001290888B8 (en) 2000-09-14 2007-07-26 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
CA2425089A1 (en) 2000-09-14 2002-03-21 Philipp Lang Assessing condition of a joint and cartilage loss
US20050165428A1 (en) * 2000-09-25 2005-07-28 Franco Kenneth L. Absorable surgical structure
EP1322234A2 (en) 2000-09-25 2003-07-02 Cohesion Technologies, Inc. Resorbable anastomosis stents and plugs
US7029486B2 (en) * 2000-09-26 2006-04-18 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US20020051730A1 (en) * 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
DE60124285T3 (de) 2000-09-29 2011-03-17 Cordis Corp., Miami Lakes Beschichtete medizinische geräte
US6296607B1 (en) * 2000-10-20 2001-10-02 Praxis, Llc. In situ bulking device
US7261735B2 (en) * 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
US20020111590A1 (en) 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
CA2422786A1 (en) * 2000-10-23 2002-05-02 Tissuemed Limited Self-adhesive hydratable matrix for topical therapeutic use
CA2446993C (en) * 2000-11-20 2009-06-02 Senorx, Inc. Tissue site markers for in vivo imaging
US20030082233A1 (en) * 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
US20030054015A1 (en) * 2000-12-25 2003-03-20 Shinichiro Haze Sympathetic-activating perfume composition
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
CA2683264C (en) * 2001-01-23 2012-10-30 Abbeymoor Medical, Inc. Endourethral device & method
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
CA2444880C (en) 2001-04-23 2009-11-24 Wisconsin Alumni Research Foundation Bifunctional-modified hydrogels
AU784394B2 (en) 2001-04-27 2006-03-23 Geistlich Pharma Ag Method and membrane for mucosa regeneration
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
US8182527B2 (en) * 2001-05-07 2012-05-22 Cordis Corporation Heparin barrier coating for controlled drug release
DE60239674D1 (de) 2001-05-25 2011-05-19 Conformis Inc Verfahren und zusammensetzungen zur reparatur der oberfläche von gelenken
US8439926B2 (en) 2001-05-25 2013-05-14 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
WO2013155501A1 (en) 2012-04-13 2013-10-17 Conformis, Inc. Patient adapted joint arthroplasty devices, surgical tools and methods of use
DE60226321T2 (de) * 2001-06-01 2009-07-09 Wyeth Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US20030003157A1 (en) * 2001-06-06 2003-01-02 University Of Medicine & Dentistry Of New Jersey Collagen compositions and methods for making and using the same
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
WO2002100444A1 (en) * 2001-06-08 2002-12-19 Biosphere Medical Inc. Colloidal metal labelled microparticles, their production and use
US6702744B2 (en) 2001-06-20 2004-03-09 Advanced Cardiovascular Systems, Inc. Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery
US6994722B2 (en) 2001-07-03 2006-02-07 Scimed Life Systems, Inc. Implant having improved fixation to a body lumen and method for implanting the same
US20030014075A1 (en) * 2001-07-16 2003-01-16 Microvention, Inc. Methods, materials and apparatus for deterring or preventing endoleaks following endovascular graft implanation
US8252040B2 (en) 2001-07-20 2012-08-28 Microvention, Inc. Aneurysm treatment device and method of use
US7572288B2 (en) 2001-07-20 2009-08-11 Microvention, Inc. Aneurysm treatment device and method of use
US8715312B2 (en) 2001-07-20 2014-05-06 Microvention, Inc. Aneurysm treatment device and method of use
US7105182B2 (en) 2001-07-25 2006-09-12 Szymaitis Dennis W Periodontal regeneration composition and method of using same
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) * 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7195640B2 (en) * 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US20030065345A1 (en) * 2001-09-28 2003-04-03 Kevin Weadock Anastomosis devices and methods for treating anastomotic sites
US7108701B2 (en) * 2001-09-28 2006-09-19 Ethicon, Inc. Drug releasing anastomosis devices and methods for treating anastomotic sites
US7157096B2 (en) * 2001-10-12 2007-01-02 Inframat Corporation Coatings, coated articles and methods of manufacture thereof
CA2464287C (en) 2001-10-23 2011-02-08 Tyco Healthcare Group Lp Surgical fasteners
CA2412012C (en) * 2001-11-20 2011-08-02 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage
US7629388B2 (en) * 2001-11-20 2009-12-08 William Marsh Rice University Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion
US8608661B1 (en) 2001-11-30 2013-12-17 Advanced Cardiovascular Systems, Inc. Method for intravascular delivery of a treatment agent beyond a blood vessel wall
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
EP1465933B1 (en) 2002-01-16 2007-08-29 Biocompatibles UK Limited Polymer conjugates
EP1465596A1 (en) * 2002-01-18 2004-10-13 Control Delivery Systems, Inc. Polymeric gel system for the controlled delivery of codrugs
JP2005517468A (ja) * 2002-02-14 2005-06-16 フォトジェネシス インコーポレイテッド 網膜下移植装置および同装置と共に使用されるカニューレ
WO2003071986A2 (en) * 2002-02-22 2003-09-04 Control Delivery Systems, Inc. Method for treating otic disorders
US20030171773A1 (en) 2002-03-06 2003-09-11 Carrison Harold F. Methods for aneurysm repair
JP2005529122A (ja) * 2002-04-25 2005-09-29 ラピッドヒール インコーポレイティッド 創傷治癒のための増殖因子送達システムならびに炎症および疾患の予防方法
US20030203032A1 (en) * 2002-04-25 2003-10-30 Schultz Clyde L. Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease
CA2483778A1 (en) * 2002-04-29 2003-11-13 Gel-Del Technologies, Inc. Biomatrix structural containment and fixation systems and methods of use thereof
CN1665525A (zh) * 2002-05-17 2005-09-07 惠氏公司 用于递送骨生成蛋白质的可注入固体透明质酸载体
EP1364663A1 (en) * 2002-05-21 2003-11-26 Commonwealth Scientific And Industrial Research Organisation Ocular devices with functionalized surface with adhesive properties
US7601688B2 (en) * 2002-06-13 2009-10-13 Biocon Limited Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US7361368B2 (en) * 2002-06-28 2008-04-22 Advanced Cardiovascular Systems, Inc. Device and method for combining a treatment agent and a gel
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
AU2003249317B2 (en) * 2002-07-19 2007-08-02 Institute Of Materials Research And Engineering Biodegradable triblock copolymers, synthesis methods therefor, and hydrogels and biomaterials made there from
KR100967334B1 (ko) 2002-09-09 2010-07-05 넥타르 테라퓨틱스 말단 카르복실산을 가진 수용성 중합체 유도체의 제조 방법
JP5156890B2 (ja) * 2002-09-11 2013-03-06 独立行政法人物質・材料研究機構 高分子架橋体及びその製造方法
US7008763B2 (en) * 2002-09-23 2006-03-07 Cheung David T Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue
AU2003284035A1 (en) 2002-10-07 2004-05-04 Conformis, Inc. Minimally invasive joint implant with 3-dimensional geometry matching the articular surfaces
US7407672B2 (en) * 2002-11-04 2008-08-05 National Heart Center Composition derived from biological materials and method of use and preparation
WO2004043305A1 (en) 2002-11-07 2004-05-27 Conformis, Inc. Methods for determing meniscal size and shape and for devising treatment
KR20040040782A (ko) 2002-11-08 2004-05-13 선바이오(주) 신규한 헥사-암 폴리에틸렌글리콜과 유도체 및 그의합성방법
US20060036158A1 (en) 2003-11-17 2006-02-16 Inrad, Inc. Self-contained, self-piercing, side-expelling marking apparatus
EP1578799B8 (en) 2002-12-02 2011-03-23 Amgen Fremont Inc. Antibodies directed to tumor necrosis factor and uses thereof
EP1583561A3 (en) * 2002-12-30 2005-12-07 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
JP2006516202A (ja) * 2002-12-30 2006-06-29 アンジオテック インターナショナル アクツィエン ゲゼルシャフト シルクステントグラフト
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
US20080208160A9 (en) * 2003-01-10 2008-08-28 Mawad Michel E Microcatheter including swellable tip
US7079091B2 (en) * 2003-01-14 2006-07-18 Eastman Kodak Company Compensating for aging in OLED devices
GB0301014D0 (en) * 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
FR2850282B1 (fr) * 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
ATE510605T1 (de) 2003-03-14 2011-06-15 Univ Columbia Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid- austauschvorrichtung
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
EP1464345B1 (en) * 2003-04-03 2009-12-30 Dennis W. Szymaitis Bone growth and adjacent tissue regeneration composition
DE602004025217D1 (es) * 2003-04-04 2010-03-11 Tissuemed Ltd
US20050074497A1 (en) * 2003-04-09 2005-04-07 Schultz Clyde L. Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US9216106B2 (en) 2003-04-09 2015-12-22 Directcontact Llc Device and method for the delivery of drugs for the treatment of posterior segment disease
US20050255144A1 (en) * 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
US7273896B2 (en) 2003-04-10 2007-09-25 Angiotech Pharmaceuticals (Us), Inc. Compositions and methods of using a transient colorant
US8038991B1 (en) 2003-04-15 2011-10-18 Abbott Cardiovascular Systems Inc. High-viscosity hyaluronic acid compositions to treat myocardial conditions
US8821473B2 (en) 2003-04-15 2014-09-02 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US7641643B2 (en) 2003-04-15 2010-01-05 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US7877133B2 (en) 2003-05-23 2011-01-25 Senorx, Inc. Marker or filler forming fluid
US8834864B2 (en) 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US8465537B2 (en) * 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
JP4500263B2 (ja) * 2003-07-28 2010-07-14 帝人株式会社 温度応答性ハイドロゲル
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US8153591B2 (en) * 2003-08-26 2012-04-10 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
KR20060133961A (ko) * 2003-09-12 2006-12-27 와이어쓰 골형성 단백질 전달용의 주사 가능한 인산칼슘 고형 로드및 페이스트
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
US7053051B2 (en) * 2003-10-28 2006-05-30 Medtronic, Inc. Methods of preparing crosslinked materials and bioprosthetic devices
AU2004289287A1 (en) * 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
AU2004289362A1 (en) * 2003-11-10 2005-05-26 Angiotech International Ag Intravascular devices and fibrosis-inducing agents
US20050273002A1 (en) * 2004-06-04 2005-12-08 Goosen Ryan L Multi-mode imaging marker
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
AU2004296851A1 (en) * 2003-12-08 2005-06-23 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
US20080109057A1 (en) * 2003-12-10 2008-05-08 Calabria Marie F Multiple point detacher system
US20070104752A1 (en) * 2003-12-10 2007-05-10 Lee Jeffrey A Aneurysm embolization material and device
RU2252787C1 (ru) * 2003-12-16 2005-05-27 ГОУ ВПО "Красноярская государственная медицинская академия" Министерства здравоохранения РФ Способ получения искусственной матрицы кожи
US20050142161A1 (en) * 2003-12-30 2005-06-30 Freeman Lynetta J. Collagen matrix for soft tissue augmentation
AU2005206549B2 (en) * 2004-01-21 2011-09-15 Nektar Therapeutics Method of preparing propionic acid-terminated polymers
AU2005219043A1 (en) * 2004-03-02 2005-09-15 Exotech Bio Solutions Ltd. Biocompatible, biodegradable, water-absorbent hybrid material
EP1735022B1 (de) * 2004-04-15 2009-07-08 Nexilis AG Osteogenes matrixkomposit, verfahren zu dessen herstellung sowie implantat und scaffold für das tissue engineering mit einer beschichtung aus einem osteogenen matrixkomposit
KR101148445B1 (ko) 2004-04-28 2012-07-05 안지오디바이스 인터내셔널 게엠베하 가교된 생합성물질을 형성하기 위한 조성물 및 시스템, 및 이와 관련된 제조 및 사용 방법
US8293890B2 (en) * 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
WO2005113608A1 (en) * 2004-05-20 2005-12-01 Mentor Corporation Method of covalently linking hyaluronan and chitosan
US20050281880A1 (en) * 2004-05-20 2005-12-22 Wei Wang Methods for making injectable polymer hydrogels
MXPA04005080A (es) * 2004-05-27 2005-11-30 Aspid S A De C V Una composicion moduladora de la inflamacion articular cronica a base de colagena-polivinilpirrolidona.
US20090117070A1 (en) * 2004-06-23 2009-05-07 Angiotech Pharmaceuticals (Us), Inc. Methods and Crosslinked Polymer Compositions for Cartilage Repair
RU2393168C2 (ru) * 2004-07-19 2010-06-27 Биокон Лимитед Инсулин-олигомерные конъюгаты, их препараты и применения
US20060025848A1 (en) * 2004-07-29 2006-02-02 Jan Weber Medical device having a coating layer with structural elements therein and method of making the same
US8357391B2 (en) 2004-07-30 2013-01-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages
KR20070051297A (ko) * 2004-08-03 2007-05-17 티슈메드 리미티드 조직-접착성 물질
US8303973B2 (en) 2004-09-17 2012-11-06 Angiotech Pharmaceuticals (Us), Inc. Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
WO2006042161A2 (en) * 2004-10-07 2006-04-20 E.I. Dupont De Nemours And Company Polysaccharide-based polymer tissue adhesive for medical use
US8790632B2 (en) * 2004-10-07 2014-07-29 Actamax Surgical Materials, Llc Polymer-based tissue-adhesive form medical use
US7845536B2 (en) 2004-10-18 2010-12-07 Tyco Healthcare Group Lp Annular adhesive structure
US7938307B2 (en) 2004-10-18 2011-05-10 Tyco Healthcare Group Lp Support structures and methods of using the same
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
ATE503465T1 (de) * 2004-10-25 2011-04-15 Celonova Biosciences Germany Gmbh Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür
US20060095121A1 (en) * 2004-10-28 2006-05-04 Medtronic Vascular, Inc. Autologous platelet gel on a stent graft
EP1807133B1 (en) * 2004-10-28 2013-12-11 SurModics, Inc. Pro-fibrotic coatings
US20060100138A1 (en) * 2004-11-10 2006-05-11 Olsen David R Implantable collagen compositions
FR2877846B1 (fr) * 2004-11-15 2008-12-05 Univ Lille Sciences Tech Biomateriaux porteurs de cyclodextrines aux proprietes d'absorption ameliorees et de liberation progressive et retardee de molecules therapeutiques
US8419656B2 (en) * 2004-11-22 2013-04-16 Bard Peripheral Vascular, Inc. Post decompression marker introducer system
US8283414B2 (en) * 2004-11-23 2012-10-09 The Johns Hopkins University Compositions comprising modified collagen and uses therefor
US20060178696A1 (en) * 2005-02-04 2006-08-10 Porter Stephen C Macroporous materials for use in aneurysms
US9050393B2 (en) 2005-02-08 2015-06-09 Bruce N. Saffran Medical devices and methods for modulation of physiology using device-based surface chemistry
JP2008530305A (ja) 2005-02-09 2008-08-07 タイコ ヘルスケア グループ エルピー 合成封止剤
US9364229B2 (en) 2005-03-15 2016-06-14 Covidien Lp Circular anastomosis structures
AU2006226818B2 (en) * 2005-03-24 2011-05-12 Medtronic, Inc. Modification of thermoplastic polymers
CA2601436A1 (en) * 2005-03-30 2006-10-05 Wyeth Methods for stimulating hair growth by administering bmps
EP1868664A2 (en) 2005-04-15 2007-12-26 Interface Biologics Inc. Methods and compositions for the delivery of biologically active agents
US20080125745A1 (en) * 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US8187621B2 (en) 2005-04-19 2012-05-29 Advanced Cardiovascular Systems, Inc. Methods and compositions for treating post-myocardial infarction damage
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US8303972B2 (en) 2005-04-19 2012-11-06 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US8828433B2 (en) 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US10357328B2 (en) 2005-04-20 2019-07-23 Bard Peripheral Vascular, Inc. and Bard Shannon Limited Marking device with retractable cannula
US20060247776A1 (en) * 2005-05-02 2006-11-02 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for augmenting intervertebral discs
CN101237857A (zh) 2005-05-09 2008-08-06 生物领域医疗公司 使用微球和非离子型造影剂的组合物和方法
US20070005140A1 (en) * 2005-06-29 2007-01-04 Kim Daniel H Fabrication and use of biocompatible materials for treating and repairing herniated spinal discs
EP1901789A2 (en) * 2005-06-30 2008-03-26 Anthrogenesis Corporation Repair of tympanic membrane using placenta derived collagen biofabric
WO2007016622A2 (en) * 2005-08-02 2007-02-08 Wright Medical Technolody, Inc. Gel composition for inhibiting cellular adhesion
US8679537B2 (en) * 2005-08-24 2014-03-25 Actamaz Surgical Materials, LLC Methods for sealing an orifice in tissue using an aldol-crosslinked polymeric hydrogel adhesive
US8679536B2 (en) * 2005-08-24 2014-03-25 Actamax Surgical Materials, Llc Aldol-crosslinked polymeric hydrogel adhesives
CA2562580C (en) 2005-10-07 2014-04-29 Inrad, Inc. Drug-eluting tissue marker
CA2635374C (en) 2006-01-11 2015-12-08 Hyperbranch Medical Technology, Inc. Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
JPWO2007083522A1 (ja) * 2006-01-18 2009-06-11 株式会社ネクスト21 医療用ゲル形成組成物,その組成物の投与デバイス及び薬剤放出制御担体
EP1986707A2 (en) 2006-01-30 2008-11-05 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
US20080039890A1 (en) * 2006-01-30 2008-02-14 Surgica Corporation Porous intravascular embolization particles and related methods
MX2008009752A (es) 2006-02-03 2008-09-19 Tissuemed Ltd Materiales adhesivos a tejidos.
CN105030297A (zh) 2006-02-06 2015-11-11 康复米斯公司 患者可选择的关节成形术装置和手术器具
US8623026B2 (en) 2006-02-06 2014-01-07 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief
US20070184087A1 (en) 2006-02-06 2007-08-09 Bioform Medical, Inc. Polysaccharide compositions for use in tissue augmentation
WO2007098066A2 (en) * 2006-02-16 2007-08-30 Stanford University Polymeric heart restraint
US20070233252A1 (en) * 2006-02-23 2007-10-04 Kim Daniel H Devices, systems and methods for treating intervertebral discs
US20090018575A1 (en) * 2006-03-01 2009-01-15 Tissuemed Limited Tissue-adhesive formulations
EP2023941B1 (en) * 2006-04-24 2016-12-21 Incept, LLC Protein crosslinkers, crosslinking methods and applications thereof
ATE542583T1 (de) 2006-05-22 2012-02-15 Univ Columbia Verfahren für membranlosen mikrofluidaustausch in einem h-filter und filterung der extraktionsflüssigkeitsausgangsströme
JP5231401B2 (ja) 2006-05-31 2013-07-10 バクスター・インターナショナル・インコーポレイテッド 脊髄の手術における導かれた細胞内殖及び制御された組織再生の方法
WO2008105791A2 (en) 2006-06-22 2008-09-04 University Of South Florida Collagen scaffolds, medical implants with same and methods of use
US7732190B2 (en) 2006-07-31 2010-06-08 Advanced Cardiovascular Systems, Inc. Modified two-component gelation systems, methods of use and methods of manufacture
TWI436793B (zh) 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
US7945307B2 (en) * 2006-08-04 2011-05-17 Senorx, Inc. Marker delivery system with obturator
US20090171198A1 (en) * 2006-08-04 2009-07-02 Jones Michael L Powdered marker
WO2008021391A1 (en) * 2006-08-15 2008-02-21 Anthrogenesis Corporation Umbilical cord biomaterial for medical use
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
WO2008033505A1 (en) * 2006-09-13 2008-03-20 University Of South Florida Biocomposite for artificial tissue design
WO2008042441A1 (en) * 2006-10-03 2008-04-10 Anthrogenesis Corporation Use of umbilical cord biomaterial for ocular surgery
WO2008060377A2 (en) 2006-10-04 2008-05-22 Anthrogenesis Corporation Placental or umbilical cord tissue compositions
CN104623642A (zh) 2006-10-06 2015-05-20 人类起源公司 天然(端肽)胎盘胶原组合物
WO2008051749A2 (en) * 2006-10-23 2008-05-02 C. R. Bard, Inc. Breast marker
US7845533B2 (en) 2007-06-22 2010-12-07 Tyco Healthcare Group Lp Detachable buttress material retention systems for use with a surgical stapling device
EP2606723B1 (en) 2006-10-27 2014-06-18 Edwards Lifesciences Corporation Biological tissue for surgical implantation
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8282959B2 (en) * 2006-11-27 2012-10-09 Actamax Surgical Materials, Llc Branched end reactants and polymeric hydrogel tissue adhesives therefrom
US8192760B2 (en) 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
EP2109409B1 (en) 2006-12-12 2018-09-05 C.R.Bard, Inc. Multiple imaging mode tissue marker
US8401622B2 (en) * 2006-12-18 2013-03-19 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
ITRM20060682A1 (it) * 2006-12-19 2008-06-20 Sicit Chemitech S P A Nuovi derivati polimerici biodegradabili
US9056151B2 (en) 2007-02-12 2015-06-16 Warsaw Orthopedic, Inc. Methods for collagen processing and products using processed collagen
EP2591756A1 (en) 2007-02-14 2013-05-15 Conformis, Inc. Implant device and method for manufacture
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227689A1 (en) 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20080220047A1 (en) 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
EP3155980B1 (en) 2007-03-06 2018-10-17 Covidien LP Surgical stapling apparatus
ES2733276T3 (es) 2007-04-13 2019-11-28 Kuros Biosurgery Ag Sellante polimérico para tejidos
US20080293637A1 (en) * 2007-05-23 2008-11-27 Allergan, Inc. Cross-linked collagen and uses thereof
WO2008157412A2 (en) 2007-06-13 2008-12-24 Conformis, Inc. Surgical cutting guide
US7665646B2 (en) 2007-06-18 2010-02-23 Tyco Healthcare Group Lp Interlocking buttress material retention system
WO2009003049A2 (en) 2007-06-25 2008-12-31 Micro Vention, Inc. Self-expanding prosthesis
US8932619B2 (en) * 2007-06-27 2015-01-13 Sofradim Production Dural repair material
US20090004455A1 (en) * 2007-06-27 2009-01-01 Philippe Gravagna Reinforced composite implant
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
CN101952324B (zh) * 2007-07-12 2014-08-13 巴斯夫欧洲公司 基于硝化纤维素的分散剂
US20090018655A1 (en) * 2007-07-13 2009-01-15 John Brunelle Composite Implant for Surgical Repair
US20090035249A1 (en) * 2007-08-02 2009-02-05 Bhatia Sujata K Method of inhibiting proliferation of Escherichia coli
GB0715514D0 (en) * 2007-08-10 2007-09-19 Tissuemed Ltd Coated medical devices
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
US20090068250A1 (en) 2007-09-07 2009-03-12 Philippe Gravagna Bioresorbable and biocompatible compounds for surgical use
US20090088723A1 (en) * 2007-09-28 2009-04-02 Accessclosure, Inc. Apparatus and methods for treating pseudoaneurysms
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
CN101939023B (zh) 2007-10-16 2016-08-03 百康有限公司 可经口给药的固体药物组合物及其方法
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
MX2010004838A (es) 2007-10-30 2010-05-21 Baxter Int Uso de una biomatriz de colageno biofuncional regenerativa para tratar defectos viscerales o parietales.
US20090110730A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
WO2009064977A2 (en) * 2007-11-14 2009-05-22 E.I. Du Pont De Nemours And Company Dextran-based polymer tissue adhesive for medical use
WO2009064963A2 (en) * 2007-11-14 2009-05-22 E. I. Du Pont De Nemours And Company Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use
MX2010005331A (es) 2007-11-16 2010-08-11 Vicept Therapeutics Inc Composiciones y metodos para tratamiento de purpura.
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
US9308068B2 (en) 2007-12-03 2016-04-12 Sofradim Production Implant for parastomal hernia
WO2009086305A2 (en) * 2007-12-21 2009-07-09 Rti Biologics, Inc. Osteoinductive putties and methods of making and using such putties
WO2009086483A2 (en) * 2007-12-26 2009-07-09 Gel-Del Technologies, Inc. Biocompatible protein particles, particle devices and methods thereof
WO2009099767A2 (en) * 2008-01-31 2009-08-13 C.R. Bard, Inc. Biopsy tissue marker
CA2714594A1 (en) 2008-02-04 2009-08-13 Edward F. Leonard Fluid separation devices, systems and methods
EP2247645B1 (en) * 2008-02-13 2017-12-06 Hyperbranch Medical Technology, Inc. Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
WO2009103012A1 (en) * 2008-02-14 2009-08-20 Tengion, Inc. Tissue engineering scaffolds
WO2009109194A2 (en) 2008-02-29 2009-09-11 Ferrosan A/S Device for promotion of hemostasis and/or wound healing
US20090227976A1 (en) * 2008-03-05 2009-09-10 Calabria Marie F Multiple biocompatible polymeric strand aneurysm embolization system and method
US8293813B2 (en) * 2008-03-05 2012-10-23 Biomet Manufacturing Corporation Cohesive and compression resistant demineralized bone carrier matrix
WO2009111626A2 (en) 2008-03-05 2009-09-11 Conformis, Inc. Implants for altering wear patterns of articular surfaces
EP2303193A4 (en) 2008-05-12 2012-03-21 Conformis Inc DEVICES AND METHOD FOR TREATING CRANE AND OTHER JOINTS
US8932622B2 (en) * 2008-06-03 2015-01-13 Actamax Surgical Materials, Llc Tissue coating for preventing undesired tissue-to-tissue adhesions
US9242026B2 (en) 2008-06-27 2016-01-26 Sofradim Production Biosynthetic implant for soft tissue repair
US8551136B2 (en) 2008-07-17 2013-10-08 Actamax Surgical Materials, Llc High swell, long-lived hydrogel sealant
US20100015231A1 (en) * 2008-07-17 2010-01-21 E.I. Du Pont De Nemours And Company Low swell, long-lived hydrogel sealant
US8450475B2 (en) 2008-08-04 2013-05-28 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
US9271706B2 (en) 2008-08-12 2016-03-01 Covidien Lp Medical device for wound closure and method of use
WO2010022180A1 (en) * 2008-08-19 2010-02-25 Micro Therapeutics, Inc. Detachable tip microcatheter
EP3184552B1 (en) 2008-09-02 2020-08-12 Tautona Group LP Threads of hyaluronic acid, methods of making thereof and uses thereof
US9387280B2 (en) * 2008-09-05 2016-07-12 Synovis Orthopedic And Woundcare, Inc. Device for soft tissue repair or replacement
US9327061B2 (en) * 2008-09-23 2016-05-03 Senorx, Inc. Porous bioabsorbable implant
CA2738494C (en) 2008-09-28 2017-06-06 Knc Ner Acquisition Sub, Inc. Multi-armed catechol compound blends
CA2740008C (en) 2008-10-09 2017-01-31 Mimedx, Inc. Methods of making biocomposite medical constructs and related constructs including artificial tissues, vessels and patches
WO2010062678A2 (en) * 2008-10-30 2010-06-03 David Liu Micro-spherical porous biocompatible scaffolds and methods and apparatus for fabricating same
WO2010053918A1 (en) 2008-11-05 2010-05-14 Hancock Jaffe Laboratories, Inc. Composite containing collagen and elastin as a dermal expander and tissue filler
WO2010057177A2 (en) 2008-11-17 2010-05-20 Gel-Del Technologies, Inc. Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof
US8466327B2 (en) 2008-11-19 2013-06-18 Actamax Surgical Materials, Llc Aldehyde-functionalized polyethers and method of making same
EP2349357B1 (en) * 2008-11-19 2012-10-03 Actamax Surgical Materials LLC Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether
CA2746094A1 (en) * 2008-12-10 2010-06-17 Microvention, Inc. Microcatheter
US20100147921A1 (en) 2008-12-16 2010-06-17 Lee Olson Surgical Apparatus Including Surgical Buttress
US20100160960A1 (en) * 2008-12-19 2010-06-24 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive having increased degradation time
CN102256660B (zh) * 2008-12-30 2013-07-03 C·R·巴德公司 用于组织标记物放置的标记物输送装置
WO2010076282A1 (en) 2008-12-31 2010-07-08 Shell Internationale Research Maatschappij B.V. Minimal gas processing scheme for recycling co2 in a co2 enhanced oil recovery flood
US20100204570A1 (en) * 2009-02-06 2010-08-12 Paul Lubock Anchor markers
US8409606B2 (en) * 2009-02-12 2013-04-02 Incept, Llc Drug delivery through hydrogel plugs
WO2010099231A2 (en) 2009-02-24 2010-09-02 Conformis, Inc. Automated systems for manufacturing patient-specific orthopedic implants and instrumentation
US8808297B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
US8808303B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
US9017334B2 (en) 2009-02-24 2015-04-28 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
US9486215B2 (en) 2009-03-31 2016-11-08 Covidien Lp Surgical stapling apparatus
WO2010118284A1 (en) 2009-04-09 2010-10-14 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive having reduced degradation time
JP2012523897A (ja) 2009-04-16 2012-10-11 コンフォーミス・インコーポレイテッド 靭帯修復のための患者固有の関節置換術の装置
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
US9162006B2 (en) 2009-06-16 2015-10-20 Baxter International Inc. Hemostatic sponge
US8580950B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
WO2011002956A1 (en) 2009-07-02 2011-01-06 E. I. Du Pont De Nemours And Company Aldehyde-functionalized polysaccharides
US8778326B2 (en) 2009-07-02 2014-07-15 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
EP2459239A1 (en) 2009-07-30 2012-06-06 Carbylan Biosurgery, Inc. Modified hyaluronic acid polymer compositions and related methods
FR2949688B1 (fr) 2009-09-04 2012-08-24 Sofradim Production Tissu avec picots revetu d'une couche microporeuse bioresorbable
US20110081398A1 (en) 2009-10-01 2011-04-07 Tyco Healthcare Group Lp Multi-mechanism surgical compositions
US20110081701A1 (en) 2009-10-02 2011-04-07 Timothy Sargeant Surgical compositions
US8968785B2 (en) 2009-10-02 2015-03-03 Covidien Lp Surgical compositions
US20110087273A1 (en) * 2009-10-08 2011-04-14 Tyco Healthcare Group Lp Wound Closure Device
US9833225B2 (en) 2009-10-08 2017-12-05 Covidien Lp Wound closure device
US8617206B2 (en) * 2009-10-08 2013-12-31 Covidien Lp Wound closure device
US20110087274A1 (en) * 2009-10-08 2011-04-14 Tyco Healtcare Group LP, New Haven, Ct Wound Closure Device
US10293553B2 (en) 2009-10-15 2019-05-21 Covidien Lp Buttress brachytherapy and integrated staple line markers for margin identification
US20150231409A1 (en) 2009-10-15 2015-08-20 Covidien Lp Buttress brachytherapy and integrated staple line markers for margin identification
US20110091549A1 (en) * 2009-10-16 2011-04-21 Confluent Surgical, Inc. Modulating Drug Release Rate By Controlling The Kinetics Of The pH Transition In Hydrogels
US9445795B2 (en) * 2009-10-16 2016-09-20 Confluent Surgical, Inc. Prevention of premature gelling of delivery devices for pH dependent forming materials
JP2013509963A (ja) 2009-11-09 2013-03-21 スポットライト テクノロジー パートナーズ エルエルシー 断片化ヒドロゲル
US9700650B2 (en) 2009-11-09 2017-07-11 Spotlight Technology Partners Llc Polysaccharide based hydrogels
US8858592B2 (en) * 2009-11-24 2014-10-14 Covidien Lp Wound plugs
IN2012DN05177A (es) 2009-12-15 2015-10-23 Incept Llc
BR112012014773A2 (pt) 2009-12-16 2015-11-03 Baxter Healthcare Sa esponja de compósito hemostática, método para fabricar uma esponja de compósito hemostática, e, uso da referida esponja
US20110171286A1 (en) * 2010-01-13 2011-07-14 Allergan, Inc. Hyaluronic acid compositions for dermatological use
US20110171311A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110172180A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
EP2353624A1 (en) 2010-02-10 2011-08-10 Université de la Méditerranée - Aix-Marseille II Embolic material, its process of preparation and its therapeutical uses thereof
US20110218606A1 (en) * 2010-03-02 2011-09-08 Medtronic Vascular, Inc. Methods for Stabilizing Femoral Vessels
US8679404B2 (en) 2010-03-05 2014-03-25 Edwards Lifesciences Corporation Dry prosthetic heart valve packaging system
NZ602405A (en) 2010-03-12 2014-12-24 Allergan Ind Sas A fluid composition comprising a hyaluronan polymer and mannitol for improving skin conditions
CA2730598C (en) 2010-03-16 2018-03-13 Confluent Surgical, Inc. Modulating drug release rate by controlling the kinetics of the ph transition in hydrogels
EP2550027B2 (en) 2010-03-22 2019-03-20 Allergan, Inc. Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
US20110243913A1 (en) * 2010-04-06 2011-10-06 Orthovita, Inc. Biomaterial Compositions and Methods of Use
SA111320355B1 (ar) * 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
US8790699B2 (en) 2010-04-23 2014-07-29 Warsaw Orthpedic, Inc. Foam-formed collagen strand
US8460691B2 (en) 2010-04-23 2013-06-11 Warsaw Orthopedic, Inc. Fenestrated wound repair scaffold
US8828181B2 (en) 2010-04-30 2014-09-09 E I Du Pont De Nemours And Company Temperature switchable adhesives comprising a crystallizable oil
JP2013525077A (ja) 2010-05-03 2013-06-20 テンジオン, インク. 平滑筋細胞構築物
US8697111B2 (en) 2010-05-12 2014-04-15 Covidien Lp Osteochondral implant comprising osseous phase and chondral phase
US8858577B2 (en) 2010-05-19 2014-10-14 University Of Utah Research Foundation Tissue stabilization system
US8945156B2 (en) 2010-05-19 2015-02-03 University Of Utah Research Foundation Tissue fixation
US8968783B2 (en) 2010-05-27 2015-03-03 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8754564B2 (en) 2010-05-27 2014-06-17 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8883185B2 (en) 2010-05-27 2014-11-11 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8734930B2 (en) 2010-05-27 2014-05-27 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8591950B2 (en) 2010-05-27 2013-11-26 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8591929B2 (en) 2010-05-27 2013-11-26 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8734824B2 (en) 2010-05-27 2014-05-27 Covidien LLP Hydrogel implants with varying degrees of crosslinking
JP5968308B2 (ja) 2010-06-01 2016-08-10 バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated 乾燥した安定な止血用組成物を作成するためのプロセス
JP5973997B2 (ja) 2010-06-01 2016-08-23 バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated 乾燥した安定な止血用組成物を作製するためのプロセス
EP2575776B1 (en) 2010-06-01 2018-05-30 Baxter International Inc Process for making dry and stable hemostatic compositions
US8409703B2 (en) 2010-07-23 2013-04-02 E I Du Pont De Nemours And Company Temperature switchable adhesive assemblies with temperature non-switchable tack
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
WO2012062360A1 (en) 2010-11-10 2012-05-18 Stryker Trauma Gmbh Polymeric bone foam composition and method
US9498317B2 (en) 2010-12-16 2016-11-22 Edwards Lifesciences Corporation Prosthetic heart valve delivery systems and packaging
CA2822429A1 (en) * 2010-12-20 2012-06-28 Microvention, Inc. Polymer stents and methods of manufacture
US8518440B2 (en) 2010-12-21 2013-08-27 Confluent Surgical, Inc. Biodegradable osmotic pump implant for drug delivery
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US8360765B2 (en) 2011-01-07 2013-01-29 Covidien Lp Systems and method for forming a coaxial implant
US8852214B2 (en) 2011-02-04 2014-10-07 University Of Utah Research Foundation System for tissue fixation to bone
JP5828643B2 (ja) * 2011-02-14 2015-12-09 学校法人 関西大学 ゼラチン水溶液を用いた弾性に富む繊維ならびに中空糸の乾式紡糸法
WO2012112702A2 (en) 2011-02-15 2012-08-23 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
EA027718B1 (ru) * 2011-02-21 2017-08-31 Этри, Инк. Коллагеновый материал и способ получения коллагенового материала
KR101879012B1 (ko) 2011-02-25 2018-07-16 마이크로벤션, 인코포레이티드 강화 풍선 카테터
US8479968B2 (en) 2011-03-10 2013-07-09 Covidien Lp Surgical instrument buttress attachment
FR2972626B1 (fr) 2011-03-16 2014-04-11 Sofradim Production Prothese comprenant un tricot tridimensionnel et ajoure
US10028745B2 (en) 2011-03-30 2018-07-24 Noha, Llc Advanced endovascular clip and method of using same
US9265830B2 (en) 2011-04-20 2016-02-23 Warsaw Orthopedic, Inc. Implantable compositions and methods for preparing the same
WO2012155093A1 (en) 2011-05-11 2012-11-15 Microvention, Inc. Device for occluding a lumen
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
RU2740454C2 (ru) 2011-06-03 2021-01-14 Аллерган Эндюстри, Сас Составы кожного наполнителя, включая антиоксиданты
US9295531B2 (en) * 2011-06-13 2016-03-29 Dentsply International Inc. Collagen coated article
CN103619886B (zh) 2011-06-29 2016-09-14 柯惠Lp公司 氧化纤维素的溶解
FR2977790B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
FR2977789B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
EP3002014A1 (en) 2011-07-28 2016-04-06 Harbor Medtech, Inc. Crosslinked human or animal tissue products and their methods of manufacture and use
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
AU2012313984B2 (en) 2011-09-30 2016-02-11 Covidien Lp Reversible stiffening of light weight mesh
WO2013046057A1 (en) 2011-09-30 2013-04-04 Sofradim Production Multilayer implants for delivery of therapeutic agents
AU2012318258B2 (en) 2011-10-11 2015-07-09 Baxter Healthcare S.A. Hemostatic compositions
US20130096063A1 (en) 2011-10-11 2013-04-18 Baxter Healthcare S.A. Hemostatic compositions
PT2771027E (pt) 2011-10-27 2015-11-26 Baxter Healthcare Sa Composições hemostáticas
US8584920B2 (en) 2011-11-04 2013-11-19 Covidien Lp Surgical stapling apparatus including releasable buttress
EP3613413A1 (en) 2011-12-05 2020-02-26 Incept, LLC Medical organogel processes and compositions
US9113885B2 (en) 2011-12-14 2015-08-25 Covidien Lp Buttress assembly for use with surgical stapling device
US9237892B2 (en) 2011-12-14 2016-01-19 Covidien Lp Buttress attachment to the cartridge surface
US9351731B2 (en) 2011-12-14 2016-05-31 Covidien Lp Surgical stapling apparatus including releasable surgical buttress
US8967448B2 (en) 2011-12-14 2015-03-03 Covidien Lp Surgical stapling apparatus including buttress attachment via tabs
FR2985170B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Prothese pour hernie inguinale
FR2985271B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Tricot a picots
KR101444877B1 (ko) 2011-12-30 2014-10-01 주식회사 삼양바이오팜 감마폴리글루탐산으로 구성된 현장 가교 수화겔 및 그의 제조 방법
US9010609B2 (en) 2012-01-26 2015-04-21 Covidien Lp Circular stapler including buttress
US9326773B2 (en) 2012-01-26 2016-05-03 Covidien Lp Surgical device including buttress material
US9010612B2 (en) 2012-01-26 2015-04-21 Covidien Lp Buttress support design for EEA anvil
US8820606B2 (en) 2012-02-24 2014-09-02 Covidien Lp Buttress retention system for linear endostaplers
CA2865349C (en) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
US9486226B2 (en) 2012-04-18 2016-11-08 Conformis, Inc. Tibial guides, tools, and techniques for resecting the tibial plateau
US9168227B2 (en) 2012-05-31 2015-10-27 Covidien Lp Multi-encapsulated microspheres made with oxidized cellulose for in-situ reactions
US9271937B2 (en) 2012-05-31 2016-03-01 Covidien Lp Oxidized cellulose microspheres
US9675471B2 (en) 2012-06-11 2017-06-13 Conformis, Inc. Devices, techniques and methods for assessing joint spacing, balancing soft tissues and obtaining desired kinematics for joint implant components
EP2825216B1 (en) 2012-06-12 2015-08-19 Ferrosan Medical Devices A/S Dry haemostatic composition
US10124087B2 (en) 2012-06-19 2018-11-13 Covidien Lp Detachable coupling for catheter
US9499636B2 (en) 2012-06-28 2016-11-22 Covidien Lp Dissolution of oxidized cellulose and particle preparation by cross-linking with multivalent cations
US10219804B2 (en) 2012-07-30 2019-03-05 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US9427309B2 (en) 2012-07-30 2016-08-30 Conextions, Inc. Soft tissue repair devices, systems, and methods
US11253252B2 (en) 2012-07-30 2022-02-22 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US10835241B2 (en) 2012-07-30 2020-11-17 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US9629632B2 (en) 2012-07-30 2017-04-25 Conextions, Inc. Soft tissue repair devices, systems, and methods
US10390935B2 (en) 2012-07-30 2019-08-27 Conextions, Inc. Soft tissue to bone repair devices, systems, and methods
US11944531B2 (en) 2012-07-30 2024-04-02 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US11957334B2 (en) 2012-07-30 2024-04-16 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
FR2994185B1 (fr) 2012-08-02 2015-07-31 Sofradim Production Procede de preparation d’une couche poreuse a base de chitosane
US20140048580A1 (en) 2012-08-20 2014-02-20 Covidien Lp Buttress attachment features for surgical stapling apparatus
CA2826786A1 (en) 2012-09-17 2014-03-17 Confluent Surgical, Inc. Multi-encapsulated formulations made with oxidized cellulose
FR2995788B1 (fr) 2012-09-25 2014-09-26 Sofradim Production Patch hemostatique et procede de preparation
FR2995778B1 (fr) 2012-09-25 2015-06-26 Sofradim Production Prothese de renfort de la paroi abdominale et procede de fabrication
FR2995779B1 (fr) 2012-09-25 2015-09-25 Sofradim Production Prothese comprenant un treillis et un moyen de consolidation
EP2900174B1 (en) 2012-09-28 2017-04-12 Sofradim Production Packaging for a hernia repair device
US9161753B2 (en) 2012-10-10 2015-10-20 Covidien Lp Buttress fixation for a circular stapler
US20140131418A1 (en) 2012-11-09 2014-05-15 Covidien Lp Surgical Stapling Apparatus Including Buttress Attachment
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
US9597426B2 (en) 2013-01-25 2017-03-21 Covidien Lp Hydrogel filled barbed suture
US20140212355A1 (en) 2013-01-28 2014-07-31 Abbott Cardiovascular Systems Inc. Trans-arterial drug delivery
US20140239047A1 (en) 2013-02-28 2014-08-28 Covidien Lp Adherence concepts for non-woven absorbable felt buttresses
BR112015021146B1 (pt) 2013-03-04 2020-06-30 DERMELLE, LLC d/b/a ETERNOGEN, LLC composição de colágeno solúvel em ácido injetável e método não terapêutico para aumentar tecidos macios
US9782173B2 (en) 2013-03-07 2017-10-10 Covidien Lp Circular stapling device including buttress release mechanism
US9782430B2 (en) 2013-03-15 2017-10-10 Covidien Lp Resorbable oxidized cellulose embolization solution
US10328095B2 (en) 2013-03-15 2019-06-25 Covidien Lp Resorbable oxidized cellulose embolization microspheres
US10413566B2 (en) 2013-03-15 2019-09-17 Covidien Lp Thixotropic oxidized cellulose solutions and medical applications thereof
FR3006578B1 (fr) 2013-06-07 2015-05-29 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
FR3006581B1 (fr) 2013-06-07 2016-07-22 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
US9775928B2 (en) 2013-06-18 2017-10-03 Covidien Lp Adhesive barbed filament
BR112015030612B1 (pt) 2013-06-21 2020-07-21 Ferrosan Medical Devices A/S método para preparar uma composição seca
US20160184474A1 (en) 2013-07-29 2016-06-30 Actamax Surgical Materials, Llc Low swell tissue adhesive and sealant formulations
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
US10173357B2 (en) 2013-09-26 2019-01-08 Northwestern University Poly(ethylene glycol) cross-linking of soft materials to tailor viscoelastic properties for bioprinting
EP3075777A4 (en) * 2013-11-26 2017-08-02 Sumitomo Chemical Company Limited Rubber composition and vulcanization aid
RU2678592C1 (ru) 2013-12-11 2019-01-30 Ферросан Медикал Дивайсиз А/С Сухая композиция, содержащая компонент, улучшающий экструзию
WO2015116646A1 (en) * 2014-01-28 2015-08-06 Mccoy Enterprises, Llc Collagen permeated medical implants
US11583384B2 (en) 2014-03-12 2023-02-21 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US9844378B2 (en) 2014-04-29 2017-12-19 Covidien Lp Surgical stapling apparatus and methods of adhering a surgical buttress thereto
EP3000489B1 (en) 2014-09-24 2017-04-05 Sofradim Production Method for preparing an anti-adhesion barrier film
US10449152B2 (en) 2014-09-26 2019-10-22 Covidien Lp Drug loaded microspheres for post-operative chronic pain
EP3000433B1 (en) 2014-09-29 2022-09-21 Sofradim Production Device for introducing a prosthesis for hernia treatment into an incision and flexible textile based prosthesis
EP3000432B1 (en) 2014-09-29 2022-05-04 Sofradim Production Textile-based prosthesis for treatment of inguinal hernia
ES2761558T3 (es) 2014-09-30 2020-05-20 Allergan Ind Sas Composiciones de hidrogel estables que incluyen aditivos
US11046818B2 (en) 2014-10-13 2021-06-29 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
WO2016065245A1 (en) 2014-10-24 2016-04-28 Incept, Llc Extra luminal scaffold
EP3029189B1 (en) 2014-12-05 2021-08-11 Sofradim Production Prosthetic porous knit, method of making same and hernia prosthesis
EP3229779B1 (en) 2014-12-10 2021-02-03 Incept, LLC Hydrogel drug delivery implants
BR112017013565B1 (pt) 2014-12-24 2021-12-28 Ferrosan Medical Devices A/S Seringa para retenção e mistura de primeira e segunda substâncias
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US10835216B2 (en) 2014-12-24 2020-11-17 Covidien Lp Spinneret for manufacture of melt blown nonwoven fabric
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
US10470767B2 (en) 2015-02-10 2019-11-12 Covidien Lp Surgical stapling instrument having ultrasonic energy delivery
EP3059255B1 (en) 2015-02-17 2020-05-13 Sofradim Production Method for preparing a chitosan-based matrix comprising a fiber reinforcement member
US11020578B2 (en) 2015-04-10 2021-06-01 Covidien Lp Surgical stapler with integrated bladder
CA2925606A1 (en) 2015-04-23 2016-10-23 Covidien Lp Resorbable oxidized cellulose embolization solution
EP3085337B1 (en) 2015-04-24 2022-09-14 Sofradim Production Prosthesis for supporting a breast structure
EP3294212B1 (en) 2015-05-12 2023-10-25 Incept, LLC Drug delivery from hydrogels
ES2676072T3 (es) 2015-06-19 2018-07-16 Sofradim Production Prótesis sintética que comprende un tejido de punto y una película no porosa y método para formarla
BR112017027695A2 (pt) 2015-07-03 2018-09-04 Ferrosan Medical Devices As seringa para retenção e mistura de primeira e segunda substâncias
US10307168B2 (en) 2015-08-07 2019-06-04 Terumo Corporation Complex coil and manufacturing techniques
EP3380077A1 (en) 2015-11-25 2018-10-03 Incept, LLC Shape changing drug delivery devices and methods
EP3195830B1 (en) 2016-01-25 2020-11-18 Sofradim Production Prosthesis for hernia repair
US10959731B2 (en) 2016-06-14 2021-03-30 Covidien Lp Buttress attachment for surgical stapling instrument
AU2017204280A1 (en) 2016-08-12 2018-03-01 Covidien Lp Thixotropic oxidized cellulose solutions and medical applications thereof
IL265421B2 (en) 2016-09-23 2024-04-01 Incept Llc Means for transferring medicine to the anterior chamber in the eye
US11696822B2 (en) 2016-09-28 2023-07-11 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
EP3312325B1 (en) 2016-10-21 2021-09-22 Sofradim Production Method for forming a mesh having a barbed suture attached thereto and the mesh thus obtained
US11026686B2 (en) 2016-11-08 2021-06-08 Covidien Lp Structure for attaching buttress to anvil and/or cartridge of surgical stapling instrument
US10874768B2 (en) 2017-01-20 2020-12-29 Covidien Lp Drug eluting medical device
US10925607B2 (en) 2017-02-28 2021-02-23 Covidien Lp Surgical stapling apparatus with staple sheath
US10912859B2 (en) 2017-03-08 2021-02-09 Baxter International Inc. Additive able to provide underwater adhesion
US11202848B2 (en) 2017-03-08 2021-12-21 Baxter International Inc. Surgical adhesive able to glue in wet conditions
US10368868B2 (en) 2017-03-09 2019-08-06 Covidien Lp Structure for attaching buttress material to anvil and cartridge of surgical stapling instrument
US11096610B2 (en) 2017-03-28 2021-08-24 Covidien Lp Surgical implants including sensing fibers
EP3398554A1 (en) 2017-05-02 2018-11-07 Sofradim Production Prosthesis for inguinal hernia repair
US10849625B2 (en) 2017-08-07 2020-12-01 Covidien Lp Surgical buttress retention systems for surgical stapling apparatus
US10945733B2 (en) 2017-08-23 2021-03-16 Covidien Lp Surgical buttress reload and tip attachment assemblies for surgical stapling apparatus
US11141151B2 (en) 2017-12-08 2021-10-12 Covidien Lp Surgical buttress for circular stapling
US12102317B2 (en) 2017-12-20 2024-10-01 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US11547397B2 (en) 2017-12-20 2023-01-10 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
KR102245539B1 (ko) 2018-02-12 2021-04-29 주식회사 지앤피바이오사이언스 코어-쉘 구조의 마이크로 입자를 유효성분으로 포함하는 성장인자 유전자 발현 증가용 조성물
EP3755236A4 (en) 2018-02-20 2021-11-17 Conextions, Inc. DEVICES, SYSTEMS AND METHODS FOR REPAIRING SOFT TISSUE AND ATTACHING SOFT TISSUE TO A BONE
US11065000B2 (en) 2018-02-22 2021-07-20 Covidien Lp Surgical buttresses for surgical stapling apparatus
US10758237B2 (en) 2018-04-30 2020-09-01 Covidien Lp Circular stapling apparatus with pinned buttress
WO2019215274A1 (en) 2018-05-09 2019-11-14 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
US11432818B2 (en) 2018-05-09 2022-09-06 Covidien Lp Surgical buttress assemblies
US11284896B2 (en) 2018-05-09 2022-03-29 Covidien Lp Surgical buttress loading and attaching/detaching assemblies
US11426163B2 (en) 2018-05-09 2022-08-30 Covidien Lp Universal linear surgical stapling buttress
US11219460B2 (en) 2018-07-02 2022-01-11 Covidien Lp Surgical stapling apparatus with anvil buttress
US10806459B2 (en) 2018-09-14 2020-10-20 Covidien Lp Drug patterned reinforcement material for circular anastomosis
CN113038908B (zh) * 2018-09-14 2024-11-12 生物智慧公司 用于组织工程化的生物管
US10952729B2 (en) 2018-10-03 2021-03-23 Covidien Lp Universal linear buttress retention/release assemblies and methods
CN113227255A (zh) * 2018-11-02 2021-08-06 科发龙技术公司 发泡组合物、发泡基质和方法
EP3653171B1 (en) 2018-11-16 2024-08-21 Sofradim Production Implants suitable for soft tissue repair
GB201905040D0 (en) 2019-04-09 2019-05-22 Cambridge Entpr Ltd Tissue equivalent scaffold structure, and methods of procution thereof
US11730472B2 (en) 2019-04-25 2023-08-22 Covidien Lp Surgical system and surgical loading units thereof
US11596403B2 (en) 2019-05-08 2023-03-07 Covidien Lp Surgical stapling device
US11478245B2 (en) 2019-05-08 2022-10-25 Covidien Lp Surgical stapling device
CA3129217A1 (en) 2019-05-29 2020-12-03 Wright Medical Technology, Inc. Preparing a tibia for receiving tibial implant component of a replacement ankle
MX2021015975A (es) * 2019-06-20 2022-05-24 Datum Biotech Ltd Un implante que comprende una membrana de colágeno.
US11969169B2 (en) 2019-09-10 2024-04-30 Covidien Lp Anvil buttress loading unit for a surgical stapling apparatus
US11571208B2 (en) 2019-10-11 2023-02-07 Covidien Lp Surgical buttress loading units
US11523824B2 (en) 2019-12-12 2022-12-13 Covidien Lp Anvil buttress loading for a surgical stapling apparatus
US11547407B2 (en) 2020-03-19 2023-01-10 Covidien Lp Staple line reinforcement for surgical stapling apparatus
US11337699B2 (en) 2020-04-28 2022-05-24 Covidien Lp Magnesium infused surgical buttress for surgical stapler
US12064330B2 (en) 2020-04-28 2024-08-20 Covidien Lp Implantable prothesis for minimally invasive hernia repair
US12102731B2 (en) 2020-05-01 2024-10-01 Harbor Medtech, Inc. Port-accessible multidirectional reinforced minimally invasive collagen device for soft tissue repair
US12161777B2 (en) 2020-07-02 2024-12-10 Davol Inc. Flowable hemostatic suspension
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
US11707276B2 (en) 2020-09-08 2023-07-25 Covidien Lp Surgical buttress assemblies and techniques for surgical stapling
US11399833B2 (en) 2020-10-19 2022-08-02 Covidien Lp Anvil buttress attachment for surgical stapling apparatus
JP2024500994A (ja) 2020-12-28 2024-01-10 デボル,インコーポレイテッド タンパク質及び多官能化変性ポリエチレングリコール系架橋剤を含む反応性乾燥粉末状止血用材料
US11534170B2 (en) 2021-01-04 2022-12-27 Covidien Lp Anvil buttress attachment for surgical stapling apparatus
US11596399B2 (en) 2021-06-23 2023-03-07 Covidien Lp Anvil buttress attachment for surgical stapling apparatus
US11510670B1 (en) 2021-06-23 2022-11-29 Covidien Lp Buttress attachment for surgical stapling apparatus
US11672538B2 (en) 2021-06-24 2023-06-13 Covidien Lp Surgical stapling device including a buttress retention assembly
US11678879B2 (en) 2021-07-01 2023-06-20 Covidien Lp Buttress attachment for surgical stapling apparatus
US11684368B2 (en) 2021-07-14 2023-06-27 Covidien Lp Surgical stapling device including a buttress retention assembly
US12076013B2 (en) 2021-08-03 2024-09-03 Covidien Lp Surgical buttress attachment assemblies for surgical stapling apparatus
US11801052B2 (en) 2021-08-30 2023-10-31 Covidien Lp Assemblies for surgical stapling instruments
WO2023030435A1 (en) 2021-09-01 2023-03-09 Shanghai Qisheng Biological Preparation Co., Ltd. Cartilage regeneration using injectable, in situ polymerizable collagen compositions containing chondrocytes or stem cells
US11751875B2 (en) 2021-10-13 2023-09-12 Coviden Lp Surgical buttress attachment assemblies for surgical stapling apparatus
US11806017B2 (en) 2021-11-23 2023-11-07 Covidien Lp Anvil buttress loading system for surgical stapling apparatus
CN118871042A (zh) 2022-02-24 2024-10-29 柯惠有限合伙公司 外科医疗装置

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3091542A (en) * 1960-09-20 1963-05-28 Dow Chemical Co Insolubilization of water-soluble cellulose ethers
US3619371A (en) * 1967-07-03 1971-11-09 Nat Res Dev Production of a polymeric matrix having a biologically active substance bound thereto
SE343210B (es) * 1967-12-20 1972-03-06 Pharmacia Ab
US3876501A (en) * 1973-05-17 1975-04-08 Baxter Laboratories Inc Binding enzymes to activated water-soluble carbohydrates
GB1479268A (en) * 1973-07-05 1977-07-13 Beecham Group Ltd Pharmaceutical compositions
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE2360794C2 (de) * 1973-12-06 1984-12-06 Hoechst Ag, 6230 Frankfurt Verfahren zur Herstellung von Peptiden
US4200557A (en) * 1973-12-07 1980-04-29 Personal Products Company Absorbent product including grafted insolubilized cellulose ether
US3949073A (en) * 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
CH596313A5 (es) * 1975-05-30 1978-03-15 Battelle Memorial Institute
US4488911A (en) * 1975-10-22 1984-12-18 Luck Edward E Non-antigenic collagen and articles of manufacture
US4002531A (en) * 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
AT352867B (de) * 1976-05-12 1979-10-10 Battelle Institut E V Knochenersatz-knochenverbund-oder prothesen- verankerungswerkstoff und verfahren zu seiner herstellung
GB1578348A (en) * 1976-08-17 1980-11-05 Pharmacia Ab Products and a method for the therapeutic suppression of reaginic antibodies responsible for common allergic
DE2900110A1 (de) * 1979-01-03 1980-07-10 Wolff Walsrode Ag Loesliche makromolekularsubstanzen mit hohem dispergier-, suspendier- und fluessigkeitsrueckhaltevermoegen, verfahren zu ihrer herstellung und verwendung
JPS6023084B2 (ja) * 1979-07-11 1985-06-05 味の素株式会社 代用血液
CS216992B1 (en) * 1980-07-21 1982-12-31 Miroslav Stol Composite polymere material for the biological and medicinal utilitation and method of preparation thereof
US4314380A (en) * 1980-09-26 1982-02-09 Koken Co., Ltd. Artificial bone
US4415665A (en) * 1980-12-12 1983-11-15 Pharmacia Fine Chemicals Ab Method of covalently binding biologically active organic substances to polymeric substances
US4414147A (en) * 1981-04-17 1983-11-08 Massachusetts Institute Of Technology Methods of decreasing the hydrophobicity of fibroblast and other interferons
EP0079364B1 (en) * 1981-05-25 1986-08-06 JACOBSEN, Anker Jarl A method for the recovery of petrol (gasoline) from a mixture of petrol vapour and air, and a system for use in the method
JPS57206622A (en) * 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
US4451568A (en) * 1981-07-13 1984-05-29 Battelle Memorial Institute Composition for binding bioactive substances
US4388428A (en) * 1981-07-20 1983-06-14 National Patent Development Corporation Biologically stabilized compositions comprising collagen as the major component with ethylenically unsaturated compounds used as contact lenses
US4357274A (en) * 1981-08-06 1982-11-02 Intermedicat Gmbh Process for the manufacture of sclero protein transplants with increased biological stability
JPS5896026A (ja) * 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
US4424208A (en) * 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
US4582640A (en) * 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
DE3380726D1 (en) * 1982-06-24 1989-11-23 Japan Chem Res Long-acting composition
US4737544A (en) * 1982-08-12 1988-04-12 Biospecific Technologies, Inc. Biospecific polymers
DE3382562D1 (de) * 1982-09-24 1992-06-25 Us Health Wiederherstellung von gewebe bei tieren.
US4973493A (en) * 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US5059654A (en) * 1983-02-14 1991-10-22 Cuno Inc. Affinity matrices of modified polysaccharide supports
JPS6028936A (ja) * 1983-07-27 1985-02-14 Koken:Kk アテロコラ−ゲン水溶液およびその製造方法
US4500676A (en) * 1983-12-15 1985-02-19 Biomatrix, Inc. Hyaluronate modified polymeric articles
US4487865A (en) * 1983-12-15 1984-12-11 Biomatrix, Inc. Polymeric articles modified with hyaluronate
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
JPS6145765A (ja) * 1984-08-07 1986-03-05 宇部興産株式会社 血管補綴物及びその製造方法
US4687820A (en) * 1984-08-22 1987-08-18 Cuno Incorporated Modified polypeptide supports
US4557764A (en) * 1984-09-05 1985-12-10 Collagen Corporation Process for preparing malleable collagen and the product thereof
US4888366A (en) * 1984-10-24 1989-12-19 Collagen Corporation Inductive collagen-based bone repair preparations
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
GB8430252D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
US4600533A (en) * 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
US4732863A (en) * 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
US4636526A (en) * 1985-02-19 1987-01-13 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
US4642117A (en) * 1985-03-22 1987-02-10 Collagen Corporation Mechanically sheared collagen implant material and method
DE3521684A1 (de) * 1985-06-18 1986-12-18 Dr. Müller-Lierheim KG, Biologische Laboratorien, 8033 Planegg Verfahren zur beschichtung von polymeren
US4766106A (en) * 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4980403A (en) * 1986-01-06 1990-12-25 The University Of Melbourne Collagen products
EP0235843A1 (de) * 1986-01-23 1987-09-09 Ipa-Isorast International S.A. Befestigungselement für die Mantelbetonbauweise
CA1283046C (en) * 1986-05-29 1991-04-16 Nandini Katre Tumor necrosis factor formulation
US4745180A (en) * 1986-06-27 1988-05-17 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using heparin fragments
US4979959A (en) * 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
ATA255988A (de) * 1988-10-14 1993-05-15 Chemie Linz Gmbh Absorbierendes polymerisat
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5201764A (en) * 1990-02-28 1993-04-13 Autogenesis Technologies, Inc. Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom
JP3008034B2 (ja) * 1990-04-23 2000-02-14 株式会社高研 体内注入可能な高濃度架橋化アテロコラ−ゲン移植用組成物
WO1992004048A2 (en) * 1990-08-30 1992-03-19 The Biomembrane Institute Inhibition of metastasis potential and invasiveness by oligosaccharides or oligosaccharide antigens or antibodies

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JPH04502027A (ja) 1992-04-09
AU4660989A (en) 1990-06-12
CA2003538C (en) 2001-02-06
US5292802A (en) 1994-03-08
US5324775A (en) 1994-06-28
EP0444157A1 (en) 1991-09-04
EP0444157B1 (en) 1998-07-22
AU638687B2 (en) 1993-07-08
WO1990005755A1 (en) 1990-05-31
US5446091A (en) 1995-08-29
JP2505312B2 (ja) 1996-06-05
US5413791A (en) 1995-05-09
EP0444157A4 (en) 1991-11-13
DE68928754T2 (de) 1999-01-14
US5328955A (en) 1994-07-12
US5162430A (en) 1992-11-10
US5550188A (en) 1996-08-27
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US5308889A (en) 1994-05-03
CA2003538A1 (en) 1990-05-21

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