DK0577847T3 - Morphinanderivat og medicinsk anvendelse deraf - Google Patents
Morphinanderivat og medicinsk anvendelse derafInfo
- Publication number
- DK0577847T3 DK0577847T3 DK93902520T DK93902520T DK0577847T3 DK 0577847 T3 DK0577847 T3 DK 0577847T3 DK 93902520 T DK93902520 T DK 93902520T DK 93902520 T DK93902520 T DK 93902520T DK 0577847 T3 DK0577847 T3 DK 0577847T3
- Authority
- DK
- Denmark
- Prior art keywords
- medical use
- nch3
- morphine derivative
- xso2
- alkylene
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Fertilizers (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1011592 | 1992-01-23 | ||
| JP29430892 | 1992-11-02 | ||
| PCT/JP1993/000080 WO1993015081A1 (fr) | 1992-01-23 | 1993-01-22 | Derive de morphinane et utilisation en medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0577847T3 true DK0577847T3 (da) | 1999-06-23 |
Family
ID=26345314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93902520T DK0577847T3 (da) | 1992-01-23 | 1993-01-22 | Morphinanderivat og medicinsk anvendelse deraf |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6323212B1 (fr) |
| EP (2) | EP0846694A1 (fr) |
| JP (1) | JP2525552B2 (fr) |
| KR (1) | KR970011390B1 (fr) |
| AT (1) | ATE172201T1 (fr) |
| AU (2) | AU666702B2 (fr) |
| CA (1) | CA2105072C (fr) |
| DE (1) | DE69321525T2 (fr) |
| DK (1) | DK0577847T3 (fr) |
| ES (1) | ES2121988T3 (fr) |
| FI (1) | FI106126B (fr) |
| NO (1) | NO302755B1 (fr) |
| NZ (1) | NZ246687A (fr) |
| TW (1) | TW332814B (fr) |
| WO (1) | WO1993015081A1 (fr) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0846694A1 (fr) | 1992-01-23 | 1998-06-10 | Toray Industries, Inc. | Dérivés de morphinane et utilisation en médicine |
| CN1111900A (zh) * | 1993-06-30 | 1995-11-15 | 东丽株式会社 | 止咳药 |
| DE69414085T2 (de) * | 1993-07-19 | 1999-03-18 | Toray Industries, Inc., Tokio/Tokyo | Wirkstoff zum schutze von gehirnzellen |
| NZ268969A (en) | 1993-07-23 | 1997-06-24 | Toray Industries | Morphinan derivatives and pharmaceutical compositions |
| SE9401727D0 (sv) * | 1994-05-18 | 1994-05-18 | Astra Ab | New compounds I |
| DE19602968A1 (de) * | 1995-12-20 | 1997-07-31 | Nycomed Arzneimittel Gmbh | Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| EP0829481A1 (fr) * | 1996-09-16 | 1998-03-18 | Pfizer Inc. | Dérivés de l'acide morphinane hydroxamique |
| ES2285733T3 (es) * | 1996-11-25 | 2007-11-16 | Toray Industries, Inc. | Agente antipruritico. |
| DE69838662T2 (de) * | 1997-03-27 | 2008-08-28 | Toray Industries, Inc. | Morphinanderivate und ihre medizinische Anwendung |
| WO1999002158A1 (fr) * | 1997-07-11 | 1999-01-21 | Toray Industries, Inc. | Compositions medicinales stables, contenant des derives de 4,5-epoxymorphinane |
| US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| IL132363A (en) * | 1997-07-14 | 2004-02-19 | Adolor Corp | Capa agonist compounds for use in the prevention or treatment of itching and antipruritic pharmaceutical preparations containing them |
| WO1999005146A1 (fr) * | 1997-07-25 | 1999-02-04 | Toray Industries, Inc. | Remedes contre l'hyponatremie |
| US6583151B2 (en) | 1997-09-02 | 2003-06-24 | Toray Industries, Inc. | Remedies for drug addiction |
| US6083944A (en) * | 1997-10-07 | 2000-07-04 | Cephalon, Inc. | Quinoline-containing α-ketoamide cysteine and serine protease inhibitors |
| TW570920B (en) * | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
| CN1204139C (zh) * | 1999-08-24 | 2005-06-01 | 东丽株式会社 | 神经性疼痛治疗剂 |
| WO2001039659A1 (fr) * | 1999-12-03 | 2001-06-07 | Iouri Malov | Essai de champ par technique d'etalement de spectre |
| WO2001074819A1 (fr) * | 2000-04-03 | 2001-10-11 | Toray Industries, Inc. | Agents analgesiques contenant des derives de n-oxyde de morphinane en tant que principe actif |
| AU2002241326B2 (en) * | 2001-03-30 | 2007-09-06 | Toray Industries, Inc | Remedies for psychoneurosis |
| WO2002080918A1 (fr) * | 2001-04-02 | 2002-10-17 | Toray Industries, Inc. | Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire |
| DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
| US7923454B2 (en) * | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| MXPA04011327A (es) | 2002-05-17 | 2005-08-15 | Jenken Biosciences Inc | Opioides y compuestos similares a opioides y usos de los mismos. |
| US7501433B2 (en) * | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| EP1555266B1 (fr) | 2002-10-09 | 2014-05-21 | Toray Industries, Inc. | Remedes ou produits preventifs pour l'incontinence urinaire, et derives de morphinane presentant un groupe heterocylique contenant de l'azote |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| WO2004108084A2 (fr) * | 2003-06-04 | 2004-12-16 | Alkermes Controlled Therapeutics, Ii | Formes polymorphes de naltrexone |
| JP5266492B2 (ja) * | 2004-05-28 | 2013-08-21 | ヒューマン バイオモレキュラル リサーチ インスティテュート | 代謝安定性鎮痛薬、疼痛薬物療法及び他の物質の合成 |
| PE20060723A1 (es) * | 2004-11-04 | 2006-08-29 | Toray Industries | Derivados de morfina como agentes analgesicos |
| EP1873158B1 (fr) * | 2005-04-06 | 2016-04-06 | Toray Industries, Inc. | Cristaux d'un derive de morphinane et procede de fabrication de ces cristaux |
| ES2307352B1 (es) * | 2005-04-12 | 2009-09-18 | Bti, I+D, S.L. | Implante dental y piezas destinadas a ser conectadas a un implante dental, y la conexion interna entre el implante dental y cada pieza. |
| EP2010539B1 (fr) * | 2006-04-21 | 2017-06-14 | Nektar Therapeutics | Réduction stéréosélective d'une morphinone |
| ES2418104T3 (es) | 2007-04-24 | 2013-08-12 | Toray Industries, Inc. | Agente terapéutico o profiláctico para la discinesia |
| JP5099127B2 (ja) | 2007-04-26 | 2012-12-12 | 東レ株式会社 | ４，５−エポキシモルヒナン誘導体を含有する安定な固形製剤 |
| ES2555785T3 (es) | 2007-06-22 | 2016-01-08 | Toray Industries, Inc. | Remedio o preventivo para esquizofrenia |
| MX2010003660A (es) | 2007-10-05 | 2010-08-10 | Toray Industries | Agente para aliviar problemas de la piel que comprende un derivado de morfinano o una sal de adicion de acido, farmacologicamente aceptable del mismo como ingrediente activo. |
| ES2671897T3 (es) * | 2008-02-14 | 2018-06-11 | Alkermes, Inc. | Compuestos opioides selectivos |
| US8609682B2 (en) | 2008-07-11 | 2013-12-17 | Regents Of The University Of Minnesota | Analgesic agents |
| JP5648480B2 (ja) | 2008-10-24 | 2015-01-07 | 東レ株式会社 | ４，５−エポキシモルヒナン誘導体を含有する安定な錠剤 |
| WO2010096791A1 (fr) * | 2009-02-23 | 2010-08-26 | Mallinckrodt Inc. | Dérivés de (+)-6-hydroxy-morphinane ou de (+)-6-amino-morphinane |
| CN102325776A (zh) * | 2009-02-23 | 2012-01-18 | 马林克罗特公司 | (+)-吗啡喃*季盐及其制备方法 |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| WO2010096790A1 (fr) * | 2009-02-23 | 2010-08-26 | Mallinckrodt Inc. | (+)-morphinane n-oxydes et procédés de préparation |
| PL2440561T3 (pl) * | 2009-06-11 | 2014-09-30 | SpecGx LLC | Redukcyjne aminowanie 6-keto-normorfinanow przez katalityczne przeniesienie wodoru |
| WO2010144641A1 (fr) * | 2009-06-11 | 2010-12-16 | Mallinckrodt Inc. | Préparation de morphinanes 6-alpha-amino n-substitués par transfert catalytique d'hydrogène |
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| AU2011211223B2 (en) | 2010-01-29 | 2014-10-23 | Toray Industries, Inc. | Therapeutic or prophylactic agent for biliary diseases |
| EP2580201B1 (fr) | 2010-06-11 | 2017-08-02 | Rhodes Technologies | Procédés catalysés par métal de transition pour la préparation de composés de n-allyle et utilisation de ceux-ci |
| JP2013529595A (ja) | 2010-06-11 | 2013-07-22 | ローズ テクノロジーズ | 第３級アミンのｎ−脱アルキル化方法 |
| JP5911484B2 (ja) * | 2010-07-16 | 2016-04-27 | マリンクロッド エルエルシー | トール様受容体９のアンタゴニストとしての（＋）−モルフィナンおよびその治療的使用 |
| MX345624B (es) | 2010-10-19 | 2017-02-08 | Memorial Sloan-Kettering Cancer Center * | Derivados 6-amido de 4,5a-epoximorfinanos para tratamiento de dolor. |
| US9006262B2 (en) | 2011-01-31 | 2015-04-14 | Toray Industries, Inc. | Therapeutic or prophylactic agent for cachexia |
| PL2718294T3 (pl) | 2011-06-09 | 2019-04-30 | SpecGx LLC | Redukcyjne aminowanie 6-keto morfinanów przez katalityczne przeniesienie wodoru |
| US8624031B2 (en) | 2011-09-08 | 2014-01-07 | Mallinckrodt Llc | Production of alkaloids without the isolation of intermediates |
| EP2884978B1 (fr) * | 2012-08-16 | 2019-07-17 | The Scripps Research Institute | Nouveaux ligands d'opioïdes kappa |
| TWI449704B (zh) * | 2013-04-26 | 2014-08-21 | Everlight Chem Ind Corp | 嗎啡喃衍生物之結晶、其製造方法、及使用其之醫藥組成物 |
| EP3077398B1 (fr) | 2013-12-05 | 2020-03-11 | The University of Bath | Nouveaux composés opioïdes et leurs utilisations |
| JP2015166331A (ja) * | 2014-05-14 | 2015-09-24 | 遼東化学工業株式会社 | ナルフラフィンの結晶およびその製造方法 |
| WO2016152953A1 (fr) * | 2015-03-24 | 2016-09-29 | 東レ株式会社 | Dérivé de morphinane et son usage médical |
| CA2983314A1 (fr) | 2015-04-30 | 2016-11-03 | Memorial Sloan-Kettering Cancer Center | Analogues de la mitragynine et leurs utilisations |
| BR112018008294A2 (pt) | 2015-10-29 | 2018-10-30 | Univ Tsukuba | derivado de morfinan, fármaco farmacêutico, composição farmacêutica, antagonista do receptor de orexina, e, agente terapêutico ou profilático e método terapêutico ou profilático. |
| MA43834A (fr) | 2016-03-22 | 2018-11-28 | Univ Minnesota | Combinaison pour traiter la douleur |
| EP3458061B1 (fr) * | 2016-05-19 | 2023-01-18 | Virginia Commonwealth University | Modulateurs puissants et sélectifs des récepteurs opioïdes mu |
| JP6814470B2 (ja) | 2017-02-10 | 2021-01-20 | 国立大学法人 筑波大学 | モルヒナン誘導体 |
| JP2021515038A (ja) * | 2018-02-27 | 2021-06-17 | デルポー・インコーポレイテッドＤｅｌｐｏｒ， Ｉｎｃ． | 小分子治療剤化合物のための組成物 |
| CA3091752A1 (fr) | 2018-03-08 | 2019-09-12 | Victoria Link Ltd | Traitement de maladies demyelinisantes |
| CN113614089B (zh) * | 2019-03-29 | 2024-08-20 | 人福医药美国公司 | 可用于治疗医学病症的新型吗啡喃 |
| CA3146163A1 (fr) * | 2019-07-08 | 2021-01-14 | University Of Health Sciences & Pharmacy In St. Louis | Agonistes/analgesiques au recepteur opioide a polarisation de proteine g a recrutement d'arrestine reduit |
| WO2021065898A1 (fr) | 2019-09-30 | 2021-04-08 | 日本ケミファ株式会社 | Dérivé d'azépane |
| EP4049658A4 (fr) | 2019-10-24 | 2023-11-22 | Toray Industries, Inc. | Agent thérapeutique ou prophylactique pour ?cachexie |
| TW202216145A (zh) | 2020-06-30 | 2022-05-01 | 日商東麗股份有限公司 | 伴隨代謝異常之疾病或症候群中的肌力低下症狀之改善劑或預防劑 |
| CN115181109B (zh) * | 2021-04-02 | 2024-06-04 | 南京正大天晴制药有限公司 | 吗啡喃衍生物的晶体及其制备方法 |
| EP4327825A4 (fr) | 2021-04-23 | 2025-03-26 | Toray Industries | Agent thérapeutique ou prophylactique pour la cachexie associée à une résistance à la ghréline |
| PE20250155A1 (es) | 2021-06-14 | 2025-01-22 | Scorpion Therapeutics Inc | Derivados de la urea que pueden ser utilizados para tratar el cancer |
| JPWO2023190665A1 (fr) * | 2022-03-29 | 2023-10-05 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3236851A (en) * | 1966-02-22 | Unsaturated morphinan derivatives | ||
| NL290054A (fr) * | ||||
| DE622231C (de) * | 1934-03-09 | 1935-11-23 | Hermann Fischer Dr | Verfahren zur Herstellung von Diacetylmorphin |
| GB864107A (en) | 1958-09-10 | 1961-03-29 | Albert Boehringer | Morphine derivatives |
| GB919311A (en) * | 1958-10-29 | 1963-02-20 | T & H Smith Ltd | Derivatives of 14-hydroxycodeine and their preparation |
| DE2254298A1 (de) * | 1972-11-06 | 1974-05-16 | Boehringer Sohn Ingelheim | Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| GB1587831A (en) * | 1977-03-23 | 1981-04-08 | Reckitt & Colmann Prod Ltd | Morphine derivatives |
| GB1593191A (en) | 1977-03-23 | 1981-07-15 | Reckitt & Colmann Prod Ltd | Derivatives of morphine |
| US4362870A (en) | 1980-01-16 | 1982-12-07 | Regents Of The University Of Minnesota | Selective opioid receptor alkylating agents |
| JPS574991A (en) * | 1980-06-10 | 1982-01-11 | Sankyo Co Ltd | Cyclopropylmethylnormorphine-6-sulfuric ester |
| US4401672A (en) | 1981-10-13 | 1983-08-30 | Regents Of The University Of Minnesota | Non-addictive narcotic antitussive preparation |
| US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| US4767718A (en) * | 1984-06-18 | 1988-08-30 | Southern Illinois University Foundation | Fluorescent opioid reagents and methods of use thereof in the detection of opioid receptors |
| IN163125B (fr) | 1985-01-08 | 1988-08-13 | Alkaloida Vegyeszeti Gyar | |
| HU196376B (en) * | 1985-05-23 | 1988-11-28 | Sandoz Ag | Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds |
| DE3617182A1 (de) | 1985-05-23 | 1986-11-27 | Sandoz-Patent-GmbH, 79539 Lörrach | Morphinan-derivate |
| US4806556A (en) | 1985-12-12 | 1989-02-21 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US4730048A (en) | 1985-12-12 | 1988-03-08 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US4673679A (en) * | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
| US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| JPH01149788A (ja) * | 1987-12-08 | 1989-06-12 | Chugai Pharmaceut Co Ltd | 新規なモルヒネ誘導体 |
| FR2636330B1 (fr) | 1988-09-13 | 1990-11-30 | Sanofi Sa | Procede de preparation de derives de morphinane |
| CA2006311A1 (fr) * | 1988-12-21 | 1990-06-21 | Ken Kanematsu | Derive de morphine |
| US5219861A (en) * | 1988-12-21 | 1993-06-15 | Chugai Seiyaku Kabushiki Kaisha | 6 β-Thiomorphine derivatives |
| US5258386A (en) * | 1991-06-05 | 1993-11-02 | The United States Of America As Represented By The Secretary Of The Army | (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents |
| EP0846694A1 (fr) * | 1992-01-23 | 1998-06-10 | Toray Industries, Inc. | Dérivés de morphinane et utilisation en médicine |
| CN1111900A (zh) * | 1993-06-30 | 1995-11-15 | 东丽株式会社 | 止咳药 |
-
1993
- 1993-01-22 EP EP98100805A patent/EP0846694A1/fr not_active Withdrawn
- 1993-01-22 KR KR1019930702860A patent/KR970011390B1/ko not_active Expired - Lifetime
- 1993-01-22 NZ NZ246687A patent/NZ246687A/en not_active IP Right Cessation
- 1993-01-22 DE DE69321525T patent/DE69321525T2/de not_active Expired - Lifetime
- 1993-01-22 US US08/108,643 patent/US6323212B1/en not_active Expired - Lifetime
- 1993-01-22 AU AU33671/93A patent/AU666702B2/en not_active Expired
- 1993-01-22 EP EP93902520A patent/EP0577847B1/fr not_active Expired - Lifetime
- 1993-01-22 DK DK93902520T patent/DK0577847T3/da active
- 1993-01-22 JP JP5509616A patent/JP2525552B2/ja not_active Expired - Lifetime
- 1993-01-22 AT AT93902520T patent/ATE172201T1/de active
- 1993-01-22 ES ES93902520T patent/ES2121988T3/es not_active Expired - Lifetime
- 1993-01-22 WO PCT/JP1993/000080 patent/WO1993015081A1/fr active IP Right Grant
- 1993-01-22 CA CA002105072A patent/CA2105072C/fr not_active Expired - Lifetime
- 1993-01-30 TW TW082100590A patent/TW332814B/zh not_active IP Right Cessation
- 1993-09-22 NO NO933376A patent/NO302755B1/no not_active IP Right Cessation
- 1993-09-22 FI FI934144A patent/FI106126B/fi not_active IP Right Cessation
-
1995
- 1995-12-22 AU AU40671/95A patent/AU686483B2/en not_active Expired
-
2000
- 2000-03-31 US US09/541,793 patent/US6277859B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO933376D0 (no) | 1993-09-22 |
| EP0577847A1 (fr) | 1994-01-12 |
| EP0577847B1 (fr) | 1998-10-14 |
| EP0577847A4 (fr) | 1994-12-07 |
| FI934144L (fi) | 1993-09-22 |
| FI934144A0 (fi) | 1993-09-22 |
| WO1993015081A1 (fr) | 1993-08-05 |
| AU4067195A (en) | 1996-03-07 |
| AU3367193A (en) | 1993-09-01 |
| US6277859B1 (en) | 2001-08-21 |
| AU686483B2 (en) | 1998-02-05 |
| AU666702B2 (en) | 1996-02-22 |
| US6323212B1 (en) | 2001-11-27 |
| TW332814B (en) | 1998-06-01 |
| NZ246687A (en) | 1996-12-20 |
| FI106126B (fi) | 2000-11-30 |
| KR970011390B1 (ko) | 1997-07-10 |
| JP2525552B2 (ja) | 1996-08-21 |
| CA2105072C (fr) | 1998-07-28 |
| NO302755B1 (no) | 1998-04-20 |
| DE69321525D1 (de) | 1998-11-19 |
| CA2105072A1 (fr) | 1993-07-24 |
| NO933376L (no) | 1993-09-23 |
| ES2121988T3 (es) | 1998-12-16 |
| ATE172201T1 (de) | 1998-10-15 |
| DE69321525T2 (de) | 1999-03-04 |
| JPH08502275A (ja) | 1996-03-12 |
| EP0846694A1 (fr) | 1998-06-10 |
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