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CL2023002074A1 - Compuestos de piridotriazina sustituidos y usos de estos - Google Patents

Compuestos de piridotriazina sustituidos y usos de estos

Info

Publication number
CL2023002074A1
CL2023002074A1 CL2023002074A CL2023002074A CL2023002074A1 CL 2023002074 A1 CL2023002074 A1 CL 2023002074A1 CL 2023002074 A CL2023002074 A CL 2023002074A CL 2023002074 A CL2023002074 A CL 2023002074A CL 2023002074 A1 CL2023002074 A1 CL 2023002074A1
Authority
CL
Chile
Prior art keywords
compounds
pyridotriazine
substituted
pharmaceutical compositions
hiv
Prior art date
Application number
CL2023002074A
Other languages
English (en)
Inventor
Devan Naduthambi
Jennifer R Zhang
Michael L Mitchell
Xiaochun Han
Hong Yang
Hang Chu
Anna E Hurtley
Lan Jiang
David W Lin
Buenrostro Ana Z Gonzalez
Hongyan Guo
Jiayao Li
Gregg M Schwarzwalder
Qiaoyin Wu
Suzanne M Szewczyk
Bargen Matthew J Von
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CL2023002074A1 publication Critical patent/CL2023002074A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente descripción se relaciona generalmente con ciertos compuestos tricíclicos, composiciones farmacéuticas que comprenden dichos compuestos y métodos para preparar dichos compuestos y composiciones farmacéuticas. Los compuestos de la descripción son útiles para tratar o prevenir la infección por el virus de inmunodeficiencia humana (VIH).
CL2023002074A 2021-01-19 2023-07-17 Compuestos de piridotriazina sustituidos y usos de estos CL2023002074A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163139237P 2021-01-19 2021-01-19
US202163190461P 2021-05-19 2021-05-19

Publications (1)

Publication Number Publication Date
CL2023002074A1 true CL2023002074A1 (es) 2024-01-12

Family

ID=80514578

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2023002074A CL2023002074A1 (es) 2021-01-19 2023-07-17 Compuestos de piridotriazina sustituidos y usos de estos
CL2024001793A CL2024001793A1 (es) 2021-01-19 2024-06-14 Compuestos de piridotriazina sustituidos y usos de estos

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2024001793A CL2024001793A1 (es) 2021-01-19 2024-06-14 Compuestos de piridotriazina sustituidos y usos de estos

Country Status (26)

Country Link
US (4) US11613546B2 (es)
EP (2) EP4196479B9 (es)
JP (3) JP7591155B2 (es)
KR (1) KR20230134529A (es)
AU (2) AU2022210247C1 (es)
CA (1) CA3202957A1 (es)
CL (2) CL2023002074A1 (es)
CO (1) CO2023009518A2 (es)
CR (1) CR20230315A (es)
DK (1) DK4196479T5 (es)
DO (1) DOP2023000139A (es)
ES (1) ES2968058T3 (es)
FI (1) FI4196479T3 (es)
HR (1) HRP20231654T2 (es)
HU (1) HUE064467T2 (es)
IL (1) IL304222A (es)
LT (1) LT4196479T (es)
MX (1) MX2023008137A (es)
PE (2) PE20242099A1 (es)
PL (1) PL4196479T3 (es)
PT (1) PT4196479T (es)
SA (1) SA523441639B1 (es)
SI (1) SI4196479T1 (es)
TW (2) TW202408533A (es)
WO (1) WO2022159387A1 (es)
ZA (1) ZA202306360B (es)

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