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CA2909625A1 - Polytherapie comprenant un inhibiteur de kinase tor et un compose de quinazolinone substitue en 5 pour le traitement du cancer - Google Patents

Polytherapie comprenant un inhibiteur de kinase tor et un compose de quinazolinone substitue en 5 pour le traitement du cancer

Info

Publication number
CA2909625A1
CA2909625A1 CA2909625A CA2909625A CA2909625A1 CA 2909625 A1 CA2909625 A1 CA 2909625A1 CA 2909625 A CA2909625 A CA 2909625A CA 2909625 A CA2909625 A CA 2909625A CA 2909625 A1 CA2909625 A1 CA 2909625A1
Authority
CA
Canada
Prior art keywords
compound
substituted
lymphoma
alkyl
tor kinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2909625A
Other languages
English (en)
Other versions
CA2909625C (fr
Inventor
Kristen Mae Hege
Rajesh Chopra
Heather Raymon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Signal Pharmaceuticals LLC
Original Assignee
Signal Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharmaceuticals LLC filed Critical Signal Pharmaceuticals LLC
Publication of CA2909625A1 publication Critical patent/CA2909625A1/fr
Application granted granted Critical
Publication of CA2909625C publication Critical patent/CA2909625C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des méthodes de traitement ou de prévention d'un cancer, consistant à administrer une quantité efficace d'un inhibiteur de kinase TOR et une quantité efficace d'un composé de quinazolinone substitué en 5 à un patient atteint d'un cancer.
CA2909625A 2013-04-17 2014-04-16 Polytherapie comprenant un inhibiteur de kinase tor et un compose de quinazolinone substitue en 5 pour le traitement du cancer Active CA2909625C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361813089P 2013-04-17 2013-04-17
US61/813,089 2013-04-17
US201361908408P 2013-11-25 2013-11-25
US61/908,408 2013-11-25
PCT/US2014/034321 WO2014172436A1 (fr) 2013-04-17 2014-04-16 Polythérapie comprenant un inhibiteur de kinase tor et un composé de quinazolinone substitué en 5 pour le traitement du cancer

Publications (2)

Publication Number Publication Date
CA2909625A1 true CA2909625A1 (fr) 2014-10-23
CA2909625C CA2909625C (fr) 2021-06-01

Family

ID=50736202

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2909625A Active CA2909625C (fr) 2013-04-17 2014-04-16 Polytherapie comprenant un inhibiteur de kinase tor et un compose de quinazolinone substitue en 5 pour le traitement du cancer

Country Status (14)

Country Link
US (1) US9474757B2 (fr)
EP (1) EP2986322A1 (fr)
JP (1) JP6382949B2 (fr)
KR (1) KR102240356B1 (fr)
CN (1) CN105339009B (fr)
AU (1) AU2014253978B2 (fr)
BR (1) BR112015026297B1 (fr)
CA (1) CA2909625C (fr)
HK (1) HK1221174A1 (fr)
IL (1) IL242100B (fr)
MX (1) MX368286B (fr)
TW (1) TWI654979B (fr)
WO (1) WO2014172436A1 (fr)
ZA (1) ZA201507730B (fr)

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PL2420497T3 (pl) 2006-09-26 2016-06-30 Celgene Corp 5-Podstawione pochodne chinazolinonu jako środki przeciwnowotworowe
TWI540127B (zh) 2011-03-11 2016-07-01 西建公司 ３－（５－胺基－２－甲基－４－氧基－４ｈ－喹唑啉－３－基）－六氫吡啶－２，６－二酮之固體型式及其醫藥組合物及用途
US9682952B2 (en) 2012-09-04 2017-06-20 Celgene Corporation Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl) piperidine-2-6-dione and methods of preparation thereof
WO2014100748A1 (fr) 2012-12-21 2014-06-26 Celgene Avilomics Research, Inc. Composés hétéroarylés et leurs utilisations
CN105358177B (zh) * 2013-04-17 2018-11-23 西格诺药品有限公司 包含tor激酶抑制剂和imid化合物的联合疗法用于治疗癌症
WO2014172426A1 (fr) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Traitement du cancer par des dihydropyrazino-pyrazines
UA115805C2 (uk) 2013-04-17 2017-12-26 Сігнал Фармасьютікалз, Елелсі Комбінована терапія, яка включає сполуку дигідропіразинопіразину й антагоніст рецептора андрогену, для лікування раку простати
KR20160004273A (ko) * 2013-04-17 2016-01-12 시그날 파마소티칼 엘엘씨 1-에틸-7-(2-메틸-6-(1H-1,2,4-트리아졸-3-일)피리딘-3-일)-3,4-디하이드로피라지노[2,3-b]피라진-2(1H)-온에 관한 약학 제제, 제조방법, 고체 형태 및 사용 방법
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CN109503591B (zh) 2013-05-29 2022-03-01 西格诺药品有限公司 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途
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WO2015160880A1 (fr) 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc Formes solides comprenant 1-éthyl-7-(2-méthyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl)-3,4-dihydropyrazino(2,3-b)pyrazin-2(1h)-one, et co-formateur, compositions et procédés d'utilisation de ces dernières
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
JP2017521396A (ja) * 2014-07-11 2017-08-03 セルジーン コーポレイション 癌のための併用療法
AU2016278040B2 (en) 2015-06-16 2019-07-04 Nanophagix LLC Drug delivery and imaging chemical conjugate, formulations and methods of use thereof
CN110996955A (zh) 2017-06-22 2020-04-10 细胞基因公司 以乙型肝炎病毒感染为特征的肝细胞癌的治疗
CA3094988A1 (fr) * 2018-03-30 2019-10-03 Biotheryx, Inc. Composes de thienopyrimidinone
KR102862736B1 (ko) * 2022-12-07 2025-09-22 부산대학교 산학협력단 신규 2-((트랜스-4-(4-아릴옥시)사이클로헥실)아미노)퀴나졸리논 유도체 및 이의 제조방법

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US9474757B2 (en) 2016-10-25
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IL242100B (en) 2019-08-29
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AU2014253978B2 (en) 2019-06-06
AU2014253978A1 (en) 2015-11-12
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US20140314753A1 (en) 2014-10-23
CN105339009A (zh) 2016-02-17
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TW201521724A (zh) 2015-06-16
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