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AP2002002698A0 - 3-Azabicyclo[3.1.0] hexane derivatives useful in therapy. - Google Patents

3-Azabicyclo[3.1.0] hexane derivatives useful in therapy.

Info

Publication number
AP2002002698A0
AP2002002698A0 APAP/P/2002/002698A AP2002002698A AP2002002698A0 AP 2002002698 A0 AP2002002698 A0 AP 2002002698A0 AP 2002002698 A AP2002002698 A AP 2002002698A AP 2002002698 A0 AP2002002698 A0 AP 2002002698A0
Authority
AP
ARIPO
Prior art keywords
opiate
useful
pharmaceutically
azabicyclo
therapy
Prior art date
Application number
APAP/P/2002/002698A
Other languages
English (en)
Inventor
Bernard Joseph Banks
Douglas James Critcher
Ashley Edward Fenwick
David Morris Gethin
Paul Stephen Gibson
Graham Lunn
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AP2002002698A0 publication Critical patent/AP2002002698A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
APAP/P/2002/002698A 2000-06-23 2001-06-07 3-Azabicyclo[3.1.0] hexane derivatives useful in therapy. AP2002002698A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0015562.2A GB0015562D0 (en) 2000-06-23 2000-06-23 Heterocycles
PCT/IB2001/001035 WO2001098267A1 (fr) 2000-06-23 2001-06-07 Derives 3-azabicyclo[3.1.0] hexane ayant une affinite pour le recepteur opioide

Publications (1)

Publication Number Publication Date
AP2002002698A0 true AP2002002698A0 (en) 2002-12-31

Family

ID=9894368

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/2002/002698A AP2002002698A0 (en) 2000-06-23 2001-06-07 3-Azabicyclo[3.1.0] hexane derivatives useful in therapy.

Country Status (34)

Country Link
EP (1) EP1292574A1 (fr)
JP (1) JP2004512263A (fr)
KR (1) KR20040002386A (fr)
CN (1) CN1639121A (fr)
AP (1) AP2002002698A0 (fr)
AR (1) AR028969A1 (fr)
AU (1) AU781837B2 (fr)
BG (1) BG107329A (fr)
BR (1) BR0111867A (fr)
CA (1) CA2412188A1 (fr)
CZ (1) CZ20023967A3 (fr)
DO (1) DOP2001000187A (fr)
DZ (1) DZ3368A1 (fr)
EA (1) EA005117B1 (fr)
GB (1) GB0015562D0 (fr)
HR (1) HRP20020998A2 (fr)
HU (1) HUP0301228A3 (fr)
IL (1) IL153427A0 (fr)
IS (1) IS6637A (fr)
MA (1) MA26915A1 (fr)
MX (1) MXPA02012878A (fr)
NO (1) NO20026168L (fr)
NZ (1) NZ523141A (fr)
OA (1) OA12293A (fr)
PA (1) PA8519401A1 (fr)
PE (1) PE20020253A1 (fr)
PL (1) PL365956A1 (fr)
SK (1) SK17172002A3 (fr)
TN (1) TNSN01094A1 (fr)
UA (1) UA73176C2 (fr)
UY (1) UY26787A1 (fr)
WO (1) WO2001098267A1 (fr)
YU (1) YU91802A (fr)
ZA (1) ZA200210278B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ531807A (en) * 2001-10-22 2006-03-31 Pfizer Prod Inc 3-Azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
RU2336871C2 (ru) * 2002-05-17 2008-10-27 Тиога Фармасьютиклз, Инк. Применение соединений, которые являются эффективными как селективные модуляторы опиатного рецептора
DE10259245A1 (de) 2002-12-17 2004-07-01 Merck Patent Gmbh Derivate des Asimadolins mit kovalent gebundenen Säuren
SI2070922T1 (sl) 2004-02-23 2011-12-30 Glaxo Group Ltd Derivati azabiciklo(3.1.0) heksana, uporabni kot modulatorji dopaminskih receptorjev d3
GB0507680D0 (en) * 2005-04-15 2005-05-25 Glaxo Group Ltd Compounds
DE602006017543D1 (de) * 2005-06-14 2010-11-25 Glaxo Group Ltd Neue verbindungen
DE602007012531D1 (de) 2006-04-03 2011-03-31 Glaxo Group Ltd Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptoren
EP2136801B1 (fr) 2007-03-30 2012-08-29 Tioga Pharmaceuticals, Inc. Agonistes du récepteur opiacé kappa pour le traitement du syndrome du côlon irritable avec alternance ou à diarrhée prédominante
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
WO2011154827A2 (fr) 2010-06-11 2011-12-15 Rhodes Technologies Procédés catalysés par métal de transition pour la préparation de composés de n-allyle et utilisation de ceux-ci
WO2012042539A2 (fr) 2010-09-28 2012-04-05 Panacea Biotec Ltd Nouveaux composés bicycliques
AU2014354085B2 (en) * 2013-11-20 2018-04-26 Ube Corporation Novel 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purposes
JP6087035B1 (ja) 2015-05-20 2017-03-01 株式会社三和化学研究所 新規３−アザビシクロ［３．１．０］ヘキサン誘導体の塩の結晶及びその医薬用途
CA3052479A1 (fr) 2017-02-17 2018-08-23 Trevena, Inc. Composes modulateurs du recepteur des opioides delta contenant des heterocycles aza a 7 chainons, et leurs procedes de preparation et d'utilisation
US11702408B2 (en) 2017-02-17 2023-07-18 Trevena, Inc. 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
US20200237720A1 (en) 2017-03-02 2020-07-30 Sanwa Kagaku Kenkyusho Co., Ltd. Therapeutic agent for alcohol use disorders
CN108250088B (zh) * 2018-01-04 2020-10-30 四川之江高新材料股份有限公司 N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法
CN115825305B (zh) * 2022-10-21 2024-09-20 昆明理工大学 一种分子印迹固相微萃取纤维及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065230A (en) * 1959-03-16 1962-11-20 Burroughs Wellcome Co Azabicyclohexanes and method of preparing them
ATE110057T1 (de) * 1987-04-16 1994-09-15 Lilly Co Eli Piperidine als opioid-antagoniste.
US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
TWI244481B (en) * 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
PE20001420A1 (es) * 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5

Also Published As

Publication number Publication date
EP1292574A1 (fr) 2003-03-19
WO2001098267A1 (fr) 2001-12-27
BR0111867A (pt) 2003-07-01
SK17172002A3 (sk) 2004-09-08
EA200201269A1 (ru) 2003-06-26
CN1639121A (zh) 2005-07-13
JP2004512263A (ja) 2004-04-22
PA8519401A1 (es) 2002-12-30
NO20026168D0 (no) 2002-12-20
CZ20023967A3 (cs) 2004-02-18
UY26787A1 (es) 2002-01-31
AU6259101A (en) 2002-01-02
WO2001098267A8 (fr) 2003-02-27
NO20026168L (no) 2003-02-18
DOP2001000187A (es) 2002-03-30
OA12293A (en) 2004-03-18
MXPA02012878A (es) 2003-05-14
AU781837B2 (en) 2005-06-16
ZA200210278B (en) 2003-12-19
BG107329A (en) 2003-07-31
PL365956A1 (en) 2005-01-24
HRP20020998A2 (en) 2004-02-29
EA005117B1 (ru) 2004-10-28
HUP0301228A3 (en) 2005-08-29
PE20020253A1 (es) 2002-04-08
IS6637A (is) 2002-11-28
GB0015562D0 (en) 2000-08-16
NZ523141A (en) 2005-06-24
KR20040002386A (ko) 2004-01-07
AR028969A1 (es) 2003-05-28
UA73176C2 (en) 2005-06-15
IL153427A0 (en) 2003-07-06
MA26915A1 (fr) 2004-12-20
YU91802A (sh) 2006-05-25
TNSN01094A1 (fr) 2005-11-10
CA2412188A1 (fr) 2001-12-27
DZ3368A1 (fr) 2001-12-27
HUP0301228A2 (hu) 2003-08-28

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