ZA93690B - Reversal of multi-drug resistance by tetraarylethylenes. - Google Patents

Reversal of multi-drug resistance by tetraarylethylenes.

Info

Publication number: ZA93690B
Authority: ZA; South Africa
Prior art keywords: tetraarylethylenes; drug resistance; reversal; certain; tumors
Prior art date: 1992-02-06

Application number

ZA93690A

Other languages

English (en)

Inventor

Sai Prasad Sunkara

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-06

Filing date

1993-02-01

Publication date

1993-09-06

1993-02-01 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1993-09-06 Publication of ZA93690B publication Critical patent/ZA93690B/xx

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicinal Preparation (AREA)

ZA93690A 1992-02-06 1993-02-01 Reversal of multi-drug resistance by tetraarylethylenes. ZA93690B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US83254192A	1992-02-06	1992-02-06

Publications (1)

Publication Number	Publication Date
ZA93690B true ZA93690B (en)	1993-09-06

Family

ID=25261952

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA93690A ZA93690B (en)	1992-02-06	1993-02-01	Reversal of multi-drug resistance by tetraarylethylenes.

Country Status (19)

Country	Link
US (2)	US5523304A (fr)
EP (1)	EP0624090B1 (fr)
JP (1)	JPH07503728A (fr)
KR (1)	KR950700061A (fr)
AT (1)	ATE142879T1 (fr)
AU (1)	AU668910B2 (fr)
CA (1)	CA2129143C (fr)
DE (1)	DE69304895T2 (fr)
DK (1)	DK0624090T3 (fr)
ES (1)	ES2094525T3 (fr)
GR (1)	GR3021811T3 (fr)
HU (1)	HUT75163A (fr)
IL (1)	IL104599A (fr)
MX (1)	MX9300578A (fr)
NO (1)	NO942918L (fr)
NZ (1)	NZ246818A (fr)
TW (1)	TW226330B (fr)
WO (1)	WO1993015733A1 (fr)
ZA (1)	ZA93690B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2198752A1 (fr)	1994-08-31	1996-03-07	Jason Scott Sawyer	Procedes d'identification et de traitement de tumeurs resistantes
JP2000512997A (ja) *	1996-06-17	2000-10-03	イーライ・リリー・アンド・カンパニー	薬物耐性および多薬物耐性調節物質
US6162616A (en) *	1997-04-16	2000-12-19	Millennium Pharmaceuticals, Inc.	Multidrug resistance-associated polypeptide
US5776939A (en) *	1997-06-12	1998-07-07	Eli Lilly And Company	Drug resistance and multidrug resistance modulators
WO2001007034A1 (fr) *	1999-07-23	2001-02-01	Colorado State University Research Foundation	Inhibiteurs de pompe a resistance multiple et utilisations
US6693099B2 (en)	2000-10-17	2004-02-17	The Procter & Gamble Company	Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en)	2000-10-17	2002-04-23	The Procter & Gamble Co.	Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
FR2906533B1 (fr) *	2006-09-28	2013-02-22	Pf Medicament	Procede de generation d'anticorps actifs contre un antigene de resistance,anticorps obtenus par ledit procede et leurs utilisations
WO2016206615A1 (fr) *	2015-06-24	2016-12-29	The Hong Kong University Of Science And Technology	Luminogènes aie pour la visualisation et le traitement du cancer
US10729669B2 (en)	2015-07-28	2020-08-04	University Of Iowa Research Foundation	Compositions and methods for treating cancer
US9980951B2 (en) *	2015-12-17	2018-05-29	University Of Iowa Research Foundation	Image guided therapy for cancer
WO2017223565A1 (fr)	2016-06-24	2017-12-28	University Of Iowa Research Foundation	Compositions et procédés de traitement d'un mélanome
US11529335B2 (en)	2020-07-31	2022-12-20	University Of Iowa Research Foundation	Compositions and methods for treating cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2914563A (en) *	1957-08-06	1959-11-24	Wm S Merrell Co	Therapeutic composition
US5236899A (en) *	1987-11-16	1993-08-17	Merck & Co., Inc.	6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
US4990538A (en) *	1989-08-23	1991-02-05	Harris Adrian L	Use of toremifene and its metabolites for the reversal of multidrug resistance of cancer cells against cytotoxic drugs
ZA908852B (en) *	1989-11-13	1991-09-25	Merrell Dow Pharma	Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones
US5182293A (en) *	1989-11-13	1993-01-26	Merrell Dow Pharmaceuticals Inc.	Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones

1993
- 1993-01-11 HU HU9402284A patent/HUT75163A/hu unknown
- 1993-01-11 WO PCT/US1993/000190 patent/WO1993015733A1/fr active IP Right Grant
- 1993-01-11 JP JP5514060A patent/JPH07503728A/ja active Pending
- 1993-01-11 NZ NZ246818A patent/NZ246818A/en unknown
- 1993-01-11 DK DK93903052.4T patent/DK0624090T3/da active
- 1993-01-11 DE DE69304895T patent/DE69304895T2/de not_active Expired - Fee Related
- 1993-01-11 AT AT93903052T patent/ATE142879T1/de not_active IP Right Cessation
- 1993-01-11 KR KR1019940702685A patent/KR950700061A/ko not_active Ceased
- 1993-01-11 ES ES93903052T patent/ES2094525T3/es not_active Expired - Lifetime
- 1993-01-11 CA CA002129143A patent/CA2129143C/fr not_active Expired - Fee Related
- 1993-01-11 AU AU34408/93A patent/AU668910B2/en not_active Ceased
- 1993-01-11 EP EP93903052A patent/EP0624090B1/fr not_active Expired - Lifetime
- 1993-02-01 ZA ZA93690A patent/ZA93690B/xx unknown
- 1993-02-02 TW TW082100675A patent/TW226330B/zh active
- 1993-02-03 MX MX9300578A patent/MX9300578A/es not_active IP Right Cessation
- 1993-02-03 IL IL10459993A patent/IL104599A/xx not_active IP Right Cessation
1994
- 1994-08-05 NO NO942918A patent/NO942918L/no unknown
- 1994-12-15 US US08/357,361 patent/US5523304A/en not_active Expired - Fee Related
1995
- 1995-12-06 US US08/568,067 patent/US5665780A/en not_active Expired - Fee Related
1996
- 1996-11-28 GR GR960403202T patent/GR3021811T3/el unknown

Also Published As

Publication number	Publication date
IL104599A0 (en)	1993-06-10
ATE142879T1 (de)	1996-10-15
TW226330B (fr)	1994-07-11
HU9402284D0 (en)	1994-10-28
ES2094525T3 (es)	1997-01-16
MX9300578A (es)	1993-08-01
EP0624090A1 (fr)	1994-11-17
EP0624090B1 (fr)	1996-09-18
NO942918D0 (fr)	1994-08-05
NZ246818A (en)	1997-07-27
CA2129143A1 (fr)	1993-08-19
AU668910B2 (en)	1996-05-23
US5665780A (en)	1997-09-09
KR950700061A (ko)	1995-01-16
CA2129143C (fr)	1997-05-06
GR3021811T3 (en)	1997-02-28
AU3440893A (en)	1993-09-03
DE69304895T2 (de)	1997-02-06
JPH07503728A (ja)	1995-04-20
US5523304A (en)	1996-06-04
DK0624090T3 (da)	1996-11-11
NO942918L (no)	1994-08-05
HUT75163A (en)	1997-04-28
IL104599A (en)	1997-01-10
DE69304895D1 (de)	1996-10-24
WO1993015733A1 (fr)	1993-08-19

Publication	Publication Date	Title
ZA93690B (en)	1993-09-06	Reversal of multi-drug resistance by tetraarylethylenes.
HU896748D0 (en)	1990-03-28	Biocid compositions
FR2671487B1 (fr)	1993-03-19	Utilisation d'un facteur de croissance dans une composition amincissante.
AU6621294A (en)	1994-11-08	Treatment of wastewater and sludges
AU7690596A (en)	1997-06-11	Anti-CD6 monoclonal antibodies and their uses
ZA923602B (en)	1993-02-24	Inhibitors of cathepsin g and elastase for preventing connective tissue degradation
DE68916117D1 (de)	1994-07-21	Fernsprech-Handapparat mit Verhinderung von elektrostatischer Entladung.
CA2152794A1 (fr)	1994-08-04	Piperidines diarylalkyliques, utiles pour traiter des tumeurs resistant a de nombreux medicaments
ATE207907T1 (de)	2001-11-15	Verwendung von tricyclischen 1,4-dihydro-1,4- dioxo-1h-naphalen derivaten, neue verbindungen und ihre therapeutische verwendung
ZA966842B (en)	1998-02-16	Transdermal administration of vorozole.
ZA962141B (en)	1997-09-15	Treatment and prevention of prostatic cancer.
FR2717209B1 (fr)	1996-05-31	Clôture constituée d'éléments en pièces détachées.
DE69824206D1 (de)	2004-07-01	Menschliches "minor vault" protein p193
AU629423B2 (en)	1992-10-01	Treatment of multi-drug resistant tumors with quinolyloxazole-2-ones
EP0612841A3 (fr)	1995-05-03	Utilisation de compositions pour le traitement du tissu.
Lee	1993	Tertiary Treatment of Municipal Wastewater
WO1998046193A3 (fr)	1999-01-21	Methode synergique de traitement du neoplasme
EP0581426A3 (fr)	1994-11-02	Instrument à sélection automatique de gamme avec des restrictions de sélection variables.
Choe et al.	1995	Three levels of logic in Treatment of Sasang Constitutional Medicine
AU6367490A (en)	1991-04-11	Treatment of waste waters by acrylic emulsions
MC2360A1 (fr)	1995-04-11	Nouveaux époxydes bicatenaires mixtes: synthèse, réactivité et applications
AU7141591A (en)	1992-05-26	Treatment of ocular hypertension with class i calcium channel blocking agents
AR244648A1 (es)	1993-11-30	Composicion floculante para el tratamiento de aguas y depuracion de efluentes.
AU4014393A (en)	1994-01-27	Treatment of sewage sludge