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WO2023031025A1 - Composition de soin d'hygiène buccale - Google Patents

Composition de soin d'hygiène buccale Download PDF

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Publication number
WO2023031025A1
WO2023031025A1 PCT/EP2022/073741 EP2022073741W WO2023031025A1 WO 2023031025 A1 WO2023031025 A1 WO 2023031025A1 EP 2022073741 W EP2022073741 W EP 2022073741W WO 2023031025 A1 WO2023031025 A1 WO 2023031025A1
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WO
WIPO (PCT)
Prior art keywords
oral care
care composition
acid
organic acid
composition according
Prior art date
Application number
PCT/EP2022/073741
Other languages
English (en)
Inventor
Katherine Mary Thompson
Original Assignee
Unilever Ip Holdings B.V.
Unilever Global Ip Limited
Conopco, Inc., D/B/A Unilever
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Ip Holdings B.V., Unilever Global Ip Limited, Conopco, Inc., D/B/A Unilever filed Critical Unilever Ip Holdings B.V.
Publication of WO2023031025A1 publication Critical patent/WO2023031025A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/42—Colour properties
    • A61K2800/43—Pigments; Dyes
    • A61K2800/432—Direct dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58—Metal complex; Coordination compounds

Definitions

  • the present invention relates to an oral care composition in particular an oral care whitening composition.
  • White teeth are considered to be cosmetically desirable.
  • Oral care compositions comprising peroxide sources are useful for cleaning and whitening teeth.
  • the peroxide may be present as hydrogen peroxide, or as a source of bound hydrogen peroxide.
  • Sources of bound hydrogen peroxide include, urea peroxide, calcium peroxide and sodium percarbonate.
  • the peroxide can bleach teeth, remove stains, and kill cariogenic bacteria.
  • peroxide compounds are highly reactive with common ingredients found in oral care..
  • hydrogen peroxide can spontaneously decompose to form oxygen gas and water, so that on storage, the composition containers may bloat, burst or leak. Consequently, the remaining formulation will have a reduced whitening and cleaning efficacy.
  • WO 96/05802 teaches an oral care composition for whitening teeth.
  • the activity is achieved by inclusion in the oral care compositions of certain organic peroxy acids as teeth whitening/bleaching agents, particularly peroxyamidophthalamides and cationic peroxycarboxylic acids such as N-phthalimido per hexanoic acid and quaternary benzylperoxyacid.
  • peracids in a whitening/bleaching agent for use on teeth would be an advantage.
  • the present invention relates to an oral care composition
  • an oral care composition comprising: flavour bleach; and • non-aromatic organic acid sequestrant comprising one or more coordinate covalent bound iron- (Fe), Manganese- (Mn) and/or cobalt- (Co) cations; and wherein the non-aromatic organic acid sequestrant is essentially free from covalently bound N or P atoms; and
  • the invention relates to the use of non-aromatic organic acid sequestrant comprising one or more coordinate covalent bound iron- (Fe), Manganese- (Mn) and/or cobalt- (Co) cations which is essentially free from covalently bound N or P atoms to provide an oral care composition with a bleach system having improved whitening and/or storage.
  • non-aromatic organic acid sequestrant comprising one or more coordinate covalent bound iron- (Fe), Manganese- (Mn) and/or cobalt- (Co) cations which is essentially free from covalently bound N or P atoms to provide an oral care composition with a bleach system having improved whitening and/or storage.
  • a further aspect of the invention relates to a method of whitening the teeth by application of a composition
  • a composition comprising bleach and non-aromatic organic acid sequestrant comprising one or more coordinate covalent bound iron- (Fe), Manganese- (Mn) and/on cobalt- (Co) cations; which is essentially free from covalently bound N or P atoms.
  • Weight percentage is based on the total weight of the oral care composition unless otherwise indicated or as made clear from the context. It will be appreciated that the total weight amount of ingredients will not exceed 100 wt. %. Whenever an amount or concentration of a component is quantified herein, unless indicated otherwise, the quantified amount or quantified concentration relates to said component per se, even though it may be common practice to add such a component in the form of a solution or of a blend with one or more other ingredients. It is furthermore to be understood that the verb "to comprise” and its conjugations is used in its non-limiting sense to mean that items following the word are included, but items not specifically mentioned are not excluded.
  • indefinite article “a” or “an” does not exclude the possibility that more than one of the elements is present, unless the context clearly requires that there be one and only one of the elements.
  • the indefinite article “a” or “an” thus usually means “at least one”. Unless otherwise specified all measurements are taken at standard conditions. Whenever a parameter, such as a concentration or a ratio, is said to be less than a certain upper limit it should be understood that in the absence of a specified lower limit the lower limit for said parameter is 0. Except in the examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and/or use may optionally be understood as modified by the word “about”.
  • composition of the invention is used to preferably used to clean and/or whiten the surfaces of the oral cavity, particularly the teeth and is known as an oral care composition.
  • the present invention relates to an oral care composition
  • an oral care composition comprising:
  • non-aromatic organic acid sequestrant comprising one or more coordinate covalent bound iron- (Fe), Manganese- (Mn) and/or cobalt- (Co) cations can be effective in promoting bleaching of stains and hence the whitening of teeth by having bleach catalyst activity.
  • non-aromatic organic acids tend to be readily biodegradable and since many are naturally occurring and can be bio-sourced.
  • Prime examples of such non-aromatic organic acid sequestrants are citric acid and D-gluconic acid. These are particularly preferred as even being safe to use in foods, further promoting consumer acceptance.
  • Concentrations expressed in wt. % of ‘free acid equivalent’ refer to the concentration of the compound expressed as wt. %, assuming it would be in fully protonated from.
  • the following table shows how the free acid equivalent concentrations can be calculated for some (anhydrous) aminopolycarboxylates and (anhydrous) acid salts.
  • Non-aromatic organic sequestrants include poly(hydroxy-acids), for example citric acid, isocitric acid, gluconic acid and malic acid; poly(carboxylic acids) such as propane- 1 ,2,3-tricarboxylic acid, 1 ,2, 3, 4 butanetetracarboxylic acid, malonic acid, succinic acid.
  • Other sequestrant include mono and poly-hydroxamates, for example alkylhydroxamates, malonic dihydroxamic acid, deferoxamine B, deferoxmine E.
  • Preferred non-aromatic organic sequestrants comprise citric acid, gluconic acid, hydroxamic acid and 1 ,2, 3, 4 butanetetracarboxylic acid, preferably citric acid and D- gluconic acid and more preferably citric acid.
  • a coordinate covalent bond also known as a dative bond, dipolar bond, or coordinate bond is a type of two-centre, two-electron covalent bond in which the two electrons derive from the same atom.
  • the bonding of metal ions to ligands generally involves this type of bond.
  • General methods to prepare organic ligand-metal ion complexes are known in the art (e.g. V. Springer et. al.
  • the preferred method of manufacture the non-aromatic organic acid sequestrant comprising one or more coordinate covalent bound iron- (Fe), Manganese- (Mn) and/or cobalt- (Co) cations comprises the following steps: a) providing an aqueous solution comprising non-aromatic organic acid sequestrant and Fe, Mn and/or Co cations, wherein the molar ratio of the non-aromatic organic acid sequestrant and the cations is from 100:1 to 1 :6; and b) optionally adjusting the pH of the aqueous solution to the range of from 6 to 11 ; and c) removing water from the aqueous solution to provide a composition comprising non-aromatic organic acid sequestrant comprising coordinate covalent bound Fe, Mn and/or Co cations and the composition having water content of at most 60 wt.% and/or precipitating the complexes from aqueous solution by adding a nonaqueous solvent (preferably an organic solvent such as ethanol).
  • step c) water is removed until a solid is provided or a precipitated solid formed on addition of an organic solvent is separated from the supernatant solution by filtration and then air dried.
  • the non-aromatic organic acid sequestrant comprising one or more coordinate covalent bound iron- (Fe), Manganese- (Mn) and/or cobalt- (Co) cations is part of the ingredients to make a tablet or powder detergent.
  • Suitable examples of such water-soluble salts are the chloride, sulphate or carbonate salts of Fe, Mn and/or Co.
  • the Fe 2+ , Fe 3+ , Mn 2+ , Mn 3+ , Mn 4+ , Mn 5+ , Mn 6+ , Mn 7+ and Co 2+ , Co 3+ are the preferred cations.
  • the cation is a Fe 2+ , Fe 3+ , Mn 2+ and/or Mn 4+ cation and particularly preferred are the Fe 3+ , Fe 2+ and Mn 2+ oxidation states.
  • the molar ratio of non-aromatic organic acid sequestrant and the cations can be from 100:1 to 1 :6. Lower ratios will lead to only a part of the non-aromatic organic acid sequestrant comprising coordinate covalent bound Fe, Mn and/or Co ions. This can be beneficial since such a non-aromatic organic acid sequestrant mixture can both contribute to effective bleaching as well as providing strong builder and chelating functionality in one go. Higher ratios are beneficial to provide a more targeted bleach catalyst activity and can allow for more than one Fe, Mn and/or Co cation to be coordinate covalent bound to the non-aromatic organic acid sequestrant. In this respect it is noted that many non-aromatic organic acid sequestrant are capable of coordinate covalent binding more than one Fe, Mn and/or Co cations.
  • Preferred compounds include [Mn"(Hcitrate)] _ , [Mn"(H2Citrate)2] 2 ', [Mn"(H2Citrate)] polymer, [Mn' ⁇ Hcitrate ⁇ ] 2 ', [Mn" 3 (Hcitrate)]2, [Mn IH (citrate)2] 5 ', [Fe IH (citrate)]', [Fe IH (Hcitrate)], [Fe IH (citrate)2] 5 ', [Fe IH 2(citrate)2] 2 ' , [Co"(H2Citrate)], [Co IH (Hcitrate)], where H 4 citrate is citric acid; [Mn"(GH 4 ) 2 ], [Mn"(GH 3 ) 2 ] 2 -, [Mn" 2 (GH 3 ) 4 ] 4 -, [Mn"(GH 3 )] 3 ', [Mn l " 2 (GH
  • An optimal balance of non-aromatic organic acid sequestrant comprising one or more coordinate covalent bound Fe, Mn or Co cations versus non-aromatic organic acid sequestrant not comprising such is considered to be from 1 :4000 to 100:1 , more preferably from 1 :100 to 20:1 , even more preferably from 1 :50 to 1 :1 and still even more preferably from 1 :20 to 1 :10.
  • Such ratios provide a balanced bleach catalyst activity and a sequestrant activity.
  • the oral care composition of the invention does not comprise further poorly biodegradable bleach catalyst and beneficially comprises essentially no further bleach catalyst (biodegradable or not).
  • the non-aromatic organic acid sequestrant has an average molecular mass of at most 500 Dalton, more preferably of at most 400 Dalton and most preferably of at most 300 Dalton, the molecular mass being based on the free acid equivalent.
  • the organic acid is not a polymer-based acid as these tend to be less biodegradable.
  • the organic acid employed in accordance with the invention preferably comprises 3 to 25 carbon atoms, more preferably 4 to 15 carbon atoms.
  • the non-aromatic organic acid sequestrant of the invention does not contain any covalently bound N or P atoms to reduce any eutrophication issues. Further preferred is that it does not contain any S atoms. In fact, the most preferred non-aromatic organic acid sequestrant of the invention (as considered from the free-acid equivalent structure) contains no other covalently bound atoms than C, H and O atoms.
  • organic acid may be used in the oral care composition of the invention and can be any organic acid. Particularly good results were achieved with organic acids being polyacids (i.e. acids having more than one carboxylic acid group), and more particularly with di- or tricarboxylic organic acids.
  • the organic acids used in the invention have an average molecular mass of at most 500 Dalton, more preferably of at most 400 Dalton and most preferably of at most 300 Dalton, the molecular mass being based on the free acid equivalent. In any case, preferably the organic acid is not a polymer-based acid.
  • the organic acid employed in accordance with the invention preferably comprises 3 to 25 carbon atoms, more preferably 4 to 15 carbon atoms.
  • the organic acids preferably are those which are also found naturally occurring, such as in plants.
  • organic acids of note are acetic acid, citric acid, aspartic acid, lactic acid, adipic acid, succinic acid, glutaric acid, malic acid, tartaric acid, maleic acid, fumaric acid, saccharic acids, their salts, or mixtures thereof.
  • Citric acid was found highly advantageous.
  • the oral care composition of the invention comprises a free acid equivalent of organic acid not comprising coordinate covalent bound Fe, Mn and/or Co cations of from 1 to 30 wt. %, more preferably of from 5 to 20 wt. % and even more preferably from 8.0 to 15 wt.%.
  • Preferred salt forms of the further organic acid are alkali metal salts and beneficially their sodium salts. pH profile
  • the oral care composition of the invention provides a pH of a solution of 1 wt.% of the oral care composition in water as measured at 25 degrees Celsius of from 6.0 to 12.0, preferably from 6.5 to 11.5, more preferably 7.0 to 11.0, even more preferably from 8.5 to 10.5 and still even more preferably from 9.0 to 10.0.
  • the oral care composition of the invention preferably comprises from 0.01 to 10 wt. % of the total composition of bleach.
  • Inorganic and/or organic bleaches can be used.
  • Bleach may be selected from peroxides, organic peracids, salts of organic peracids and combinations thereof.
  • the bleach is selected from peroxides (including peroxide salts such as sodium percarbonate), organic peracids, salts of organic peracids and combinations thereof. More preferably, the bleach is a peroxide. Most preferably, the bleach is a percarbonate particularly preferred is sodium percarbonate.
  • bleach more preferably the peroxide source is present in the composition in an amount of from 0.05 weight percent to 5 weight percent, from 0.1 weight percent to 3 weight percent, or from 0.1 weight percent to 1 weight percent, by total weight of the composition.
  • level of bleach is from 0.01 to 10 wt. %, preferably from 0.05 to 5 wt. % most preferably from 0.1 to 2 wt% of the total composition.
  • the dentifrice/toothpaste is in the form of an extrudable semi-solid such as a cream, paste or gel (or mixture thereof).
  • a composition according to the invention (such as a dentifrice/toothpaste) will generally contain further ingredients to enhance performance and/or consumer acceptability, in addition to the ingredients specified above.
  • compositions according to the invention particularly toothpastes, preferably comprise particulate abrasive materials such as silicas, aluminas, calcium carbonates, and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the oral care composition.
  • particulate abrasive materials such as silicas, aluminas, calcium carbonates, and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the oral care composition.
  • the composition particularly a toothpaste, comprises a silica based abrasive.
  • the preferred abrasive silicas used in the present invention is a silica with a low refractive index. It may be used as the sole abrasive silica, or in conjunction with a low level of other abrasive silicas, e.g. those according to EP 236070.
  • the low refractive index silicas, used as abrasives in the present invention are preferably silicas with an apparent refractive index (R.l.) in the range of 1.41 - 1.47, preferably 1.435 - 1.445, preferably having a weight mean particle size of between 5 and 15 mm, a BET (nitrogen) surface area of between 10 and 100 m 2 /g and an oil absorption of about 70 - 150 cm 3 /100 g, but abrasive silicas with a lower apparent refractive index may also be used.
  • suitable low refractive index abrasive silicas e.g. having an R.l.
  • silicas of between 1.435 and 1.445 are Tixosil 63 and 73 ex Rhone Poulenc; Sident 10 ex Degussa; Zeodent 113 ex Zeofinn; Zeodent 124 ex Evonik, Sorbosil AC 77 ex PQ Corporation (having an R.l. of approximately 1.440).
  • the amount of these silicas in the composition generally ranges from 5-60% by weight, usually 5-20% by weight.
  • composition particularly if a toothpaste preferably comprises an inorganic or a natural or synthetic thickener or gelling agent in proportions of about 0.10 to about 15% by weight depending on the material chosen.
  • thickeners in the dentifrice compositions of the present invention form an extrudable, shape-retaining product which can be squeezed from a tube onto a toothbrush and will not fall between the bristles of the brush but rather, will substantially maintain its shape thereon.
  • Suitable thickeners or gelling agents useful in the practice of the present invention include inorganic thickening silicas such as amorphous silicas available from Huber Corporation under the trade designation Zeodent 165, Irish moss, iota-carrageenan, gum tragacanth, and polyvinylpyrrolidone.
  • inorganic thickening silicas such as amorphous silicas available from Huber Corporation under the trade designation Zeodent 165, Irish moss, iota-carrageenan, gum tragacanth, and polyvinylpyrrolidone.
  • compositions according to the invention preferably comprise a polymeric deposition aid.
  • the composition comprises acid anhydride polymers, particularly preferred are co-polymers of maleic anhydride with methyl vinylether, in which the anhydride moiety may be in a partially or fully hydrolysed or alcoholysed form.
  • Preferred copolymers include Gantrez(R) polymers such as: Gantrez S-95: molecular weight 216,000; free acid;
  • Gantrez S-96 molecular weight 700,000; free acid
  • Gantrez S-97 molecular weight 1 ,500,000; free acid
  • Gantrez MS-955 molecular weight 1,060,000; calcium/sodium salt.
  • compositions according to the invention may comprise a further tooth whitening agent.
  • the whitening agent preferably comprises a green and/or a blue pigment.
  • a pigment is generally understood to be a shade/material which is insoluble in the relevant medium, at the relevant temperature. This is in contrast to dyes which are soluble.
  • the "relevant medium” is human saliva, the liquid medium in which the composition is used, at the temperature of the oral cavity during brushing of the teeth, i.e. up to 37 Degrees C. As a reasonable approximation, the relevant medium may be considered to be water and the relevant temperature to be 25 Degrees C.
  • the blue pigment is Pigment Blue 15, more preferably Pigment Blue 15:1, 15:2, 15:3, 15:4, 15:5 or 15:6, most preferably 15:1.
  • a preferred pigment is blue pigment is Phthalocyanine Blue Pigment, Cl No. 74160, blue covarine.
  • the preferred Green pigment is Phthalocyanine Green, preferably Phthalocyanine Green CI-74260.
  • the total level of pigment in the composition is from 0.01 wt% to 3 wt, more preferably from 0.02 to 2 wt%.
  • composition is a toothpaste it is preferably a dual phase paste, with the aminopolycarboxylate comprising one or more coordinate covalent bound iron- (Fe), Manganese- (Mn) and/or cobalt- (Co) cations and the whitening pigments present in one phase and separate from the bleach.
  • aminopolycarboxylate comprising one or more coordinate covalent bound iron- (Fe), Manganese- (Mn) and/or cobalt- (Co) cations and the whitening pigments present in one phase and separate from the bleach.
  • compositions according to the invention may comprise water-soluble or sparingly water-soluble sources of metal salts
  • zinc ions such as zinc chloride, zinc acetate, zinc gluconate, zinc sulphate, zinc fluoride, zinc citrate, zinc lactate, zinc oxide, zinc monoglycerolate, zinc tartrate, zinc pyrophosphate and zinc maleate
  • stannous ions such as stannous fluoride and stannous chloride.
  • compositions according to the invention may comprise oral care enzyme systems such as hydrogen peroxide producing enzyme systems (e.g. the oxidoreductase enzyme glucose oxidase), amyloglucosidase, dextranase and/or mutanase, (optionally in the presence of zinc ion providing compounds and/or 8- hydroxyquinoline derivatives), lactoperoxidase, lactoferrin, lysozyme and mixtures thereof.
  • hydrogen peroxide producing enzyme systems e.g. the oxidoreductase enzyme glucose oxidase
  • amyloglucosidase e.g. the oxidoreductase enzyme glucose oxidase
  • dextranase and/or mutanase e.g. the oxidoreductase enzyme glucose oxidase
  • mutanase e.g. the mutanase
  • lactoperoxidase e.g. the
  • Compositions of the invention may comprises fluoride sources such as sodium fluoride, stannous fluoride, sodium monofluorophosphate, zinc ammonium fluoride, tin ammonium fluoride, calcium fluoride, cobalt ammonium fluoride and mixtures thereof.
  • fluoride sources such as sodium fluoride, stannous fluoride, sodium monofluorophosphate, zinc ammonium fluoride, tin ammonium fluoride, calcium fluoride, cobalt ammonium fluoride and mixtures thereof.
  • a preferred class of oral care active for inclusion in the compositions of the invention includes agents for the remineralisation of teeth.
  • remineralisation in the context of the present invention means the in situ generation of hydroxyapatite on teeth.
  • composition according the invention will comprise further ingredients which are common in the art, such as: antimicrobial agents, e.g. chlorhexidine, sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; cetylpyridium chloride clay complex bis-guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; and halogenated bisphenolic compounds, such as 2,2' methylenebis-(4-chloro-6-bromophenol); anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc.; anti-caries agents such as sodium- and stannous fluoride, aminefluorides, sodium monofluorophosphate, sodium trimeta phosphate and casein; plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates; vitamins such as Vitamins A,
  • Humectants such as glycerol, sorbitol, propyleneglycol, xylitol, lactitol etc.; binders and thickeners such as sodium carboxymethyl-cellulose, hydroxyethyl cellulose (Natrosol®), xanthan gum, gum arabic etc. as well as synthetic polymers such as polyacrylates and carboxyvinyl polymers such as Carbopol®; polymeric compounds which can enhance the delivery of active ingredients such as antimicrobial agents can also be included; buffers and salts to buffer the pH and ionic strength of the oral care composition; and other optional ingredients that may be included are e.g. bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
  • bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/c
  • the oral care composition is preferably phosphate-free, i.e., contains at most 1.0 wt. %, preferably at most 0.8 wt.%, more preferably at most 0.5 wt. %, of phosphate .
  • the oral care composition is preferably also phosphonate-free i.e., contains at most 0.2 wt. % of phosphonate, preferably at most 0.1 wt. %, more preferably at most 0.05 wt. %, still even more preferably contains essentially no phosphonate.
  • the oral care composition of the invention may be in any suitable form, the compositions may be provided as a dentifrice, a whitening gel, a mouthwash or a mouthrinse, a spray, an oral strip, a chewing gum or a lozenge.
  • An oral strip comprises a flexible material with the composition applied to the surface or impregnating the surface.
  • a base solution was made by dispersing 0.005 wt. % of naphthol blue black dye (available from Sigma-Aldrich) in water and adjusting the pH to 10 (using 0.1 M bicarbonate). To this solution hydrogen peroxide was added to provide a level of 20mM. For testing either 25ppm of bleach catalyst according to the invention was added, or (not according to the invention) bare Mn 2+ (as water soluble MnSOt), bare ferrous or ferric iron (as water soluble ferrous sulphate or ferric chloride) as controls. The final solution was incubated at 20 degrees Celsius for 20 hours after which the absorbance was measured at 629 nm. The results are given in the Table 1 below.

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Abstract

L'invention concerne une composition de soin d'hygiène buccale comprenant : un arôme ; un agent de blanchiment ; un agent séquestrant acide organique non aromatique comprenant un ou plusieurs cations de fer (Fe), manganèse (Mn) et/ou cobalt (Co) liés par liaison covalente coordonnée ; et l'agent séquestrant acide organique non aromatique étant sensiblement exempt d'atomes de N ou de P liés par liaison covalente.
PCT/EP2022/073741 2021-09-01 2022-08-26 Composition de soin d'hygiène buccale WO2023031025A1 (fr)

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