WO2019113653A1 - Capsule à deux sections pour substances médicamenteuses - Google Patents
Capsule à deux sections pour substances médicamenteuses Download PDFInfo
- Publication number
- WO2019113653A1 WO2019113653A1 PCT/AZ2017/000008 AZ2017000008W WO2019113653A1 WO 2019113653 A1 WO2019113653 A1 WO 2019113653A1 AZ 2017000008 W AZ2017000008 W AZ 2017000008W WO 2019113653 A1 WO2019113653 A1 WO 2019113653A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- capsule
- lid
- partition
- drug
- parts
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 51
- 239000003814 drug Substances 0.000 title claims abstract description 15
- 229940079593 drug Drugs 0.000 title claims abstract description 14
- 238000005192 partition Methods 0.000 claims abstract description 15
- 239000000126 substance Substances 0.000 claims description 9
- 238000011068 loading method Methods 0.000 claims description 3
- 238000011049 filling Methods 0.000 abstract description 7
- 230000002035 prolonged effect Effects 0.000 abstract description 6
- 210000000936 intestine Anatomy 0.000 abstract description 3
- 210000002784 stomach Anatomy 0.000 abstract description 3
- 239000000825 pharmaceutical preparation Substances 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 description 9
- 239000000463 material Substances 0.000 description 7
- 108010010803 Gelatin Proteins 0.000 description 5
- 239000008273 gelatin Substances 0.000 description 5
- 229920000159 gelatin Polymers 0.000 description 5
- 235000019322 gelatine Nutrition 0.000 description 5
- 235000011852 gelatine desserts Nutrition 0.000 description 5
- 239000013543 active substance Substances 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229940088623 biologically active substance Drugs 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940072185 drug for treatment of tuberculosis Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000012907 medicinal substance Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000000941 radioactive substance Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- ODKYYBOHSVLGNU-IAGONARPSA-N terizidone Chemical compound O=C1NOCC1\N=C\C(C=C1)=CC=C1\C=N\C1C(=O)NOC1 ODKYYBOHSVLGNU-IAGONARPSA-N 0.000 description 1
- 229960003457 terizidone Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 239000000814 tuberculostatic agent Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
Definitions
- the present utility model relates to new, multi-part capsules for pharmaceutical preparations intended for oral administration of two incompatible drugs.
- Hard capsules or bivalves consist of two cylindrical parts that are telemetrically inserted into each other: bodies with a hemispherical base and a lid of the same shape but shorter. The inner diameter of the cap is actually equal to the diameter of the case.
- Capsules are usually made from gelatin.
- capsules are made of; Hemmed from well-digestible water-soluble plastics that provide, when taken orally, the release of active substances in certain parts of the gastrointestinal tract.
- BP 0460921 describes capsules consisting of two parts, consisting of chitosia starch, cereal flour, oligosaccharides, methyl acrylate, methacridic acid, acetate, succinate, or hydroxypropionimetry dacellose phthalate. Capsule material is different in that its contents are released only in the large intestine.
- OV 938828 describes capsules for radioactive substances used in therapy or diagnosis. Such capsules are made from water-soluble gelatin, cellulose cellulose, novnimido alcohol or non-toxic water-soluble thermoplastics.
- RU 96115307 A (27, 10, 1998 PCT (TB 94/02703, A61 K 9/48) claims a pharmaceutical form in the form of two-phase capsules, comprising a capsule having one compartment containing at least two filling compositions, characterized by what prevents the compositions from mixing with each other.
- the two compositions are separated: a physical septum, which contains an additional closure of a material that is different from the material of the capsule.
- the material of the partition contains a material having a melting point
- the pharmaceutical form may include a first filling composition containing a pharmaceutically active substance for a short release when not pareteralny administered, and a second filling composition containing a pharmaceutically active substance for a prolonged release when administered parenterally.
- the pharmaceutical form may include a first filling composition containing a biologically active substance, and a second filling composition containing a substance adapted to bring the pH of the intestine to a pH value of from 7.5 to 9.
- the encapsulated drug is claimed.
- the capsule body has inside two or more compartments separated by a partition for pharmaceutical compositions.
- Known utility model [YAN 98132 U1, A61 K 9/48, A611C 31/4409. 10.10.2010], which is a solid capsule of an anti-tuberculosis drug, consisting of a solid gelatin detachable shell, made in the form of a body and a lid, in which terizidone granules and a tablet of niridoxine hydrochloride are coated, coated, the jerks of this fissile granule and pirndkoine hydrochloride tablet are made in therapeutically affective amounts and contain auxiliary pharmaceutically acceptable substances.
- the disadvantage of the capsules described in the prior art is that they release the contents of the capsules in one specific section of the gastrointestinal tract.
- the objective of the invention is to isolate incompatible pharmaceuticals in a single capsule, which can provide a prolonged release of a specific pharmaceutical agent in the desired part of the gastrointestinal tract, as well as to simplify the design of the capsule while maintaining its integrity.
- the declared two-section capsule for medicinal substances which has a solid rim, made in the form of connected parts of the body and the cover, and of which the body is made from two the sides are open and with an integral partition inside, which divides it into two lengths for loading the medicinal substance into both parts of the capsule
- the lid is cylindrical with an open horseback on one side and a closed part spherically with an end on the other, while the body is from the open ends, not far from the edge, grooved with the groove but the outer perimeter of the cylinder, and the lid is made with a protrusion along the inner perimeter closer to the closed hemispherical end, forming a “lock” that provides mutual interlocking of the body and the lid.
- the body, lid and partition are made gastro-soluble with a prolonged drug release in one part, or the body, the lid and partition are made intestine-soluble with a prolonged drug release in one part, or one part of the capsule is made gastro-soluble and the other ⁇ intestinal para f f vorimoy.
- the partition is made of gastro-soluble and enteric)> th and can be placed inside the body, forming different volumes of medicinal substances,
- Figure 1 shows the capsule, a general view; figure 2 is the same, a longitudinal section; on fsh ⁇ 3 - body, in longitudinal section; figure 4 - cover.
- the capsule has a hard shell (figure 1, figure 2), made in the form of a cylindrical body 1 about a partition 2 inside and connected to the case on both sides of the cover 3.
- the case 1 (fig.Z) is open on both sides and with a one-piece partition 2 inside, which is made of it in two lengths for loading the drug into both parts of the capsule.
- the cover 3 (FIG. 4) is cylindrical with an open condom on one side and a closed hemispherical end on the other.
- Case 1 from the side of the open ends, close to the edge, is made with a groove along the outer perimeter of the cylinder, and the lid is made with a protrusion along the inner perimeter closer to the closed hemispherical end, forming a “lock” that provides mutual interlocking of the case and the lid.
- the capsule is made in a conventional manner by dipping into the solution gelatin fingers that have the shape of a lid, body and partition for drying gelatin on the fingers with an aaoc-cutting of blanks of the required length.
- Other pharmaceutical acceptable hydrophilic polymers can be used as capsules.
- a plasticizer sorbitol
- a capsule mass is injected into the capsule mass or applied to the surface of the capsule an enteric or intramuscular capsule.
- Hard gelatin capsules of irodogirovany action obtained by introducing special ingredients (acrylic polymers, cellulose derivatives) in the composition of the filler product. Used combinations of substances prevent the rapid release of the active components of the capsule.
- the capsule is filled as follows. Case 1 is filled with a dosed amount of one drug, tightly worn the lid 2 with a “lock” lock, turn it over, fill it with the dosed amount of another doctor from the opposite open end of the case! The agent can be closed tightly with lid 2 “locking” the capsule.
- the capsule can be made gastro-soluble (ga-merciful), or enteric-guaranty (shpooooooooyinoy.) with a prolonged release of one of its parts, or enteric soluble is another.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
Le modèle d'utilité de l'invention se rapporte à des capsules à deux sections pour des préparations pharmaceutiques à prise orale. L'invention concerne une capsule à deux sections pour substances médicamenteuses comprenant une enveloppe solide se présentant sous forme de parties à connecter d'un corps et d'un couvercle, dans laquelle le corps est ouvert des deux côtés et comporte une cloison interne inamovible qui le sépare en deux longueurs pour charger une substance médicamenteuse dans les deux parties de la capsule; le couvercle est cylindrique avec une extrémité ouverte d'un côté et une extrémité hémisphérique close de l'autre; le corps, du côté des extrémités ouvertes et non loin du bord, comprend une gorge suivant le périmètre externe du cylindre, et le couvercle comporte une protubérance sur le périmètre interne à proximité de l'extrémité hémisphérique close, formant ainsi un verrou assurant le blocage mutuel du corps et du couvercle. Cette capsule peut être soluble dans l'estomac ou soluble dans l'intestin avec une diffusion prolongée de la substance médicamenteuse depuis une des parties, ou une partie de la capsule est soluble dans l'estomac et l'autre est soluble dans l'intestin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/AZ2017/000008 WO2019113653A1 (fr) | 2017-12-11 | 2017-12-11 | Capsule à deux sections pour substances médicamenteuses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/AZ2017/000008 WO2019113653A1 (fr) | 2017-12-11 | 2017-12-11 | Capsule à deux sections pour substances médicamenteuses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2019113653A1 true WO2019113653A1 (fr) | 2019-06-20 |
Family
ID=66818789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/AZ2017/000008 WO2019113653A1 (fr) | 2017-12-11 | 2017-12-11 | Capsule à deux sections pour substances médicamenteuses |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2019113653A1 (fr) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4449983A (en) * | 1982-03-22 | 1984-05-22 | Alza Corporation | Simultaneous delivery of two drugs from unit delivery device |
| US4738817A (en) * | 1983-11-17 | 1988-04-19 | Warner-Lambert Company | Method for forming pharmaceutical capsules from hydrophilic polymers |
| WO2001036290A1 (fr) * | 1999-11-17 | 2001-05-25 | Reckitt Benckiser (Uk) Limited | Contenants solubles dans l'eau moules par injection |
-
2017
- 2017-12-11 WO PCT/AZ2017/000008 patent/WO2019113653A1/fr active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4449983A (en) * | 1982-03-22 | 1984-05-22 | Alza Corporation | Simultaneous delivery of two drugs from unit delivery device |
| US4738817A (en) * | 1983-11-17 | 1988-04-19 | Warner-Lambert Company | Method for forming pharmaceutical capsules from hydrophilic polymers |
| WO2001036290A1 (fr) * | 1999-11-17 | 2001-05-25 | Reckitt Benckiser (Uk) Limited | Contenants solubles dans l'eau moules par injection |
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