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WO2019039497A1 - Outil de chauffage - Google Patents

Outil de chauffage Download PDF

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Publication number
WO2019039497A1
WO2019039497A1 PCT/JP2018/030926 JP2018030926W WO2019039497A1 WO 2019039497 A1 WO2019039497 A1 WO 2019039497A1 JP 2018030926 W JP2018030926 W JP 2018030926W WO 2019039497 A1 WO2019039497 A1 WO 2019039497A1
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WO
WIPO (PCT)
Prior art keywords
sheet
layer
heat generating
cooling agent
heating
Prior art date
Application number
PCT/JP2018/030926
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English (en)
Japanese (ja)
Inventor
穂貴 高桑
和俊 大塚
Original Assignee
花王株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 花王株式会社 filed Critical 花王株式会社
Priority to CN201880054217.7A priority Critical patent/CN111031973A/zh
Publication of WO2019039497A1 publication Critical patent/WO2019039497A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F7/03—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction

Definitions

  • the present invention relates to a heating tool.
  • a steam heater which comprises an oxidizable metal such as iron powder, an electrolyte such as sodium chloride and water, and utilizes the heat of oxidation generated by the oxidation reaction of the oxidizable metal.
  • a steam heating tool utilizes that it can supply a chemical
  • a steam heating implement for the purpose of alleviating this is disclosed. That is, from the viewpoint of alleviating a hot feeling by simultaneously imparting a warm feeling and a cool feeling, a heat generating tool in which a cooling agent such as menthol is contained in the heat generating portion is disclosed.
  • Patent Document 2 in the heating tool containing a chemical solution such as menthol, from the viewpoint of suppressing the delamination between the layer coated with the chemical solution and the layer coated with the heating element, By forming the area, a technique is disclosed that suppresses the delamination by utilizing the surface tension of the uncoated area and the heat generating layer.
  • the present invention A breathable first sheet, The second sheet, A heat generating layer disposed between the first sheet and the second sheet; A drug layer disposed between the heat generating layer and the second sheet; Equipped with The air permeability from the heat generating layer to the first sheet is configured to be higher than the air permeability from the heat generating layer to the second sheet,
  • the drug layer provides a heating tool comprising a drug composition containing a cooling agent and a solvent having a molecular weight of 1,000 or less.
  • FIG. 1 It is a sectional view showing a heating implement concerning an embodiment of the present invention. It is sectional drawing which shows the heat generating body concerning embodiment of this invention. It is a perspective view showing a heating element. It is a sectional view showing a part of exothermic part. It is a figure showing an example of a state where a user wears a heating implement.
  • Patent Document 2 focuses on delamination, and does not focus on such a user's request and does not sufficiently meet the request.
  • the air permeability is a value measured according to JIS P8117, and is defined as a time in which 100 ml of air passes an area of 6.45 cm 2 under a constant pressure.
  • the air permeability can be measured with an Oken type air permeability meter or a measuring instrument according thereto. That is, high air permeability means that the passage of air takes time, that is, air permeability is low. Conversely, low air permeability means high air permeability.
  • the basis weight means the mass with respect to the area in planar view of a heat-generating layer.
  • FIG. 1 is a cross-sectional view showing a heating implement according to an embodiment of the present invention.
  • FIG. 2 is a cross-sectional view showing a heating element according to an embodiment of the present invention.
  • the heating implement 1 is disposed between the first sheet 11 having air permeability, the second sheet 12, and the first sheet 11 and the second sheet 12, and is disposed in parallel 2 Provided with two heating elements 18. That is, the heating implement 1 has an outer bag made of the first sheet 11 and the second sheet 12. Further, as shown in FIG.
  • the inner bag 17 which accommodates the heat-emitting part 20 in an inside.
  • the inner bag 17 is configured by joining the sheet 171 and the peripheral portion of the sheet 172.
  • the heating implement 1 includes the first sheet 11 having air permeability, the second sheet 12, the heat generating layer 13 disposed between the first sheet 1 and the second sheet 12, the heat generating layer 13 and the second layer. And a drug layer 16 disposed between the sheets 12.
  • the heating implement 1 is configured such that the air permeability from the heat generating layer 13 to the first sheet 11 is higher than the air permeability from the heat generating layer 13 to the second sheet 12.
  • the thermal steam generated in the heat generating layer 13 is less likely to be released to the outside from the second sheet 12 side, and preferentially released from the first sheet 11 side.
  • the thermal steam and the cooling agent can be effectively supplied to the skin of the user.
  • the first adhesive layer 14 and the second adhesive layer 15 are formed on the outer surface of the first sheet 11, and the release paper 21 is provided thereon.
  • the release paper 21 can be peeled off at the time of use of the heating tool 1, and the heating tool 1 can be fixed to the skin of the user by the first adhesive layer 14 and the second adhesive layer 15; It is suppressed that the tool 1 detaches from the user, and the user can be stably supplied with the thermal steam.
  • the heat generating portion 20 has a structure in which the base layer 10, the drug layer 16, the heat generating layer 13, and the water retaining layer 19 are laminated in this order.
  • the heat generating layer 13 generates steam when it generates heat, and is composed of a heat generating composition containing at least an oxidizable metal and water, for example, an oxidizable metal, a carbon component, water, etc. ing.
  • the oxidizable metal is a metal that emits the heat of oxidation reaction, and examples thereof include powders and fibers such as iron, aluminum, zinc, manganese, magnesium, calcium, and mixed metals in which two or more of these are mixed.
  • the oxidizable metal preferably has an average particle diameter of 10 ⁇ m or more, more preferably 15 ⁇ m or more, and still more preferably 20 ⁇ m or more from the viewpoint of efficient oxidation reaction, when it is powdered. .
  • the average particle diameter of the oxidizable metal is preferably 200 ⁇ m or less, more preferably 180 ⁇ m or less, and still more preferably 150 ⁇ m or less.
  • the particle size of the oxidizable metal refers to the maximum length in the form of powder, and can be measured by classification with a sieve, dynamic light scattering method, laser diffraction method, etc., among which laser diffraction method It is preferable to measure.
  • the content of the oxidizable metal in the heat generating layer 13 is preferably 100 g / m in terms of basis weight from the viewpoint that the heat generating layer 13 can be raised to a desired temperature in the heating implement 1 provided with the drug layer 16. It is 2 or more, More preferably, it is 200 g / m ⁇ 2 > or more, More preferably, it is 300 g / m ⁇ 2 > or more, More preferably, it is 500 g / m ⁇ 2 > or more.
  • the content of the oxidizable metal in the heat generating layer 13 is preferably not more than 3,000 g / m 2, more preferably not more than 2,000 g / m 2, more preferably 1 , 500 g / m 2 or less.
  • the content of the oxidizable metal in the heat generating layer 13 can be determined by an ash content test according to JIS P8128 or a thermogravimeter.
  • when an external magnetic field is applied it can be quantified by a vibrating sample type magnetization measurement test or the like by utilizing the property of generating magnetization. Among them, it is preferable to use a thermogravimeter.
  • the carbon component has a water holding ability, an oxygen supplying ability, and a catalytic ability, and may use, for example, one or more materials selected from the group consisting of activated carbon, carbon black, acetylene black, and graphite. it can. Among them, activated carbon is preferably used because oxygen is easily adsorbed when wet. In addition, one or two or more types of fine powder or small particles selected from the group consisting of coconut shell charcoal, wood flour charcoal, and peat charcoal are more preferably used. Wood charcoal is more preferable from the viewpoint of facilitating the surface temperature of the heating element 18 to rise to a desired temperature.
  • the carbon component preferably has an average particle diameter of 10 ⁇ m or more, more preferably 12 ⁇ m or more, and still more preferably 15 ⁇ m or more, from the viewpoint of being uniformly mixed with the oxidizable metal. From the same viewpoint, the average particle diameter of the carbon component is preferably 200 ⁇ m or less, more preferably 150 ⁇ m or less, and still more preferably 100 ⁇ m or less.
  • the average particle size of the carbon component refers to the maximum length in the form of powder, and can be measured by a dynamic light scattering method, a laser diffraction method, etc., among which it is preferable to measure by a laser diffraction method. .
  • the carbon component is preferably in the form of powder, but may be in the form other than powder, for example, in the form of fiber.
  • the content of the carbon component in the heat generating layer 13 is preferably 1 part by mass or more with respect to 100 parts by mass of the content of the oxidizable metal from the viewpoint of sufficient supply of water to the heat generating layer 13. More preferably, it is 3 mass parts or more, More preferably, it is 6 mass parts or more.
  • the content of the carbon component in the heat generating layer 13 is preferably 40 parts by mass or less with respect to 100 parts by mass of the oxidizable metal from the viewpoint that oxygen supply to the heat generating layer 13 is sufficiently obtained. More preferably, it is 15 parts by mass or less, and more preferably 12 parts by mass or less.
  • the content of the carbon component in the heat generating layer 13 is preferably 10 g / m 2 or more, more preferably 20 g / m 2 or more, and still more preferably 25 g / m 2 or more in terms of basis weight. is there.
  • the content of the carbon component is preferably 400 g / m 2 or less, more preferably 250 g / m 2 or less, and still more preferably 120 g / m 2 or less, in terms of basis weight.
  • the content of water in the heat generating layer 13 is preferably 20 parts by mass or more, more preferably 30 parts by mass with respect to 100 parts by mass of the oxidizable metal, from the viewpoint of favorably advancing the oxidation reaction of the oxidizable metal. It is at least a part by mass, more preferably at least 40 parts by mass.
  • the content of water in the heat generating layer 13 is preferably 100 parts by mass or less, and more preferably 90 parts by mass or less, with respect to 100 parts by mass of the oxidizable metal, from the viewpoint of setting the highest temperature to a predetermined temperature or higher. More preferably, it is 80 parts by mass or less.
  • a part of water in the heat generating layer 13 becomes water vapor due to the temperature rise accompanying heat generation due to the oxidation reaction of the oxidizable metal.
  • a water absorbing agent can be contained in the heat generating layer 13 in order to retain moisture and efficiently advance the oxidation reaction of the oxidizable metal.
  • a polymer having water absorbency or a powder having water absorbency can be used as the water absorbing agent.
  • the polymer having water absorbability examples include hydrophilic polymers having a cross-linked structure capable of absorbing and holding a liquid 20 times or more of its own weight, and as powder having water absorbency, vermiculite, sawdust, silica gel, and pulp powder And at least one powder selected from the group consisting of
  • the content of the water absorbing agent is preferably 2 parts by mass or more, preferably 20 parts by mass or less, and 15 parts by mass or less with respect to 100 parts by mass of water in the heat generating layer 13. It is more preferable that
  • the heat generating layer 13 can further contain a reaction accelerator.
  • a reaction accelerator By including a reaction accelerator, the oxidation reaction of the oxidizable metal can be easily sustained.
  • the oxide film formed on the oxidizable metal accompanying the oxidation reaction can be destroyed to promote the oxidation reaction.
  • the reaction accelerator includes, for example, one or more materials selected from the group consisting of alkali metal and sulfate or chloride of alkaline earth metal. Among them, various chlorides such as sodium chloride, potassium chloride, calcium chloride, magnesium chloride, ferrous chloride, and ferric chloride, and sodium sulfate from the viewpoint of excellent conductivity, chemical stability, and production cost. It is preferable to use one or more materials selected from the group.
  • a thickener When a thickener is included in the heat generating composition, it is possible to suppress a decrease in heat generating characteristics during storage of the heat generating body 18.
  • a substance which absorbs moisture to increase the consistency or which imparts thixotropy can be used, and alginates such as sodium alginate, gum arabic, gum tragacanth, locust Polysaccharide thickeners such as bean gum, guar gum, gum arabic gum, carrageenan, agar, and xanthan gum; starch thickeners such as dextrin, pregelatinized starch, and starch for processing; carboxymethylcellulose, ethylcellulose, hydroxyethylcellulose, Cellulose derivative thickeners such as hydroxymethyl cellulose and hydroxypropyl cellulose; metal soap thickeners such as stearates; mineral thickeners such as bentonite, etc. One or two or more selected from these can be used. .
  • the heat generating composition contains a phosphate
  • it has the effect of increasing the flowability of the heat generating composition, so that it becomes easy to manufacture when the heat generating layer 13 is manufactured by applying it to a substrate such as paper.
  • a phosphate 1 type or 2 types or more selected from a primary phosphate potassium salt, a secondary phosphate potassium salt, a tertiary phosphate potassium salt, a primary phosphate sodium salt, and a secondary phosphate sodium salt Can be used.
  • the heat generating layer 13 may be a powder or a molded product of powder, or may be a sheet, and in the present embodiment, it is a sheet of a rectangular shape (square, rectangle) in plan view.
  • the heat generating layer 13 is in the form of a sheet in this embodiment, the heat generating layer 13 may be in the form of powder or in the form of a sheet. However, it is preferable to be in the form of a sheet from the viewpoint of being excellent in the feeling in use.
  • the heat generating layer 13 for example, one obtained by wet forming a heat generating composition, one formed by pressing the heat generating composition, one formed by sandwiching the heat generating composition with the substrate layer 10 described later, heat generation What disperse
  • the basis weight of the base material layer 10 is preferably 10 g / m 2 or more and 200 g / m 2 or less, and more preferably 35 g / m 2 or more and 150 g / m 2 or less.
  • a sheet in which a hydrophilic layer 10 a and a liquid impermeable layer 10 b are laminated and laminated is used.
  • the hydrophilic layer 10a is a layer containing hydrophilic fibers. It is preferable that it is 20 to 99.9 mass%, and, as for the ratio of the hydrophilic fiber contained in the whole in the base material layer 10, it is more preferable that it is 50 to 99.5 mass%.
  • the hydrophilic fiber for example, it is preferable to use a cellulose fiber.
  • cellulose fiber chemical fiber (synthetic fiber) and natural fiber can be used.
  • rayon and acetate can be used as the chemical fiber of cellulose.
  • natural cellulose fibers include various plant fibers such as wood pulp, non-wood pulp, cotton, hemp, wheat straw, hemp, jute, kapok, coconut, and rag.
  • wood pulp is preferably used from the viewpoint that thick fibers can be easily obtained.
  • Examples of the resin constituting the liquid impermeable layer 10 b include resins such as polyolefins such as polyethylene and polypropylene, polyesters, polyamides, polyurethanes, polystyrenes, nylons, polyvinylidene chlorides, and polyethylene-vinyl acetate copolymers.
  • resins such as polyolefins such as polyethylene and polypropylene, polyesters, polyamides, polyurethanes, polystyrenes, nylons, polyvinylidene chlorides, and polyethylene-vinyl acetate copolymers.
  • a known laminating process can be used as a laminating method of the hydrophilic layer 10a and the liquid impermeable layer 10b.
  • the base material layer 10 is preferably located on the side farther from the skin than the heat generating layer 13, and the hydrophilic layer 10 a is preferably on the side closer to the heat generating layer 13.
  • the drug layer 16 is composed of a cooling agent and a drug composition containing a solvent having a molecular weight of 1,000 or less. That is, it is different from the prior art in which the drug composition is impregnated into the heat generating portion. In addition, the drug layer 16 supplies the cooling agent to the user together with the thermal steam when the thermal implement 1 is used. The heating implement 1 can improve the volatilization of the cooling agent by including the drug layer 16.
  • the drug layer 16 is formed by any method, as shown in FIG. 2, when the heat generating portion 20 has the base layer 10, the drug layer 16 includes a cooling agent and a solvent having a molecular weight of 1,000 or less.
  • the drug composition is preferably formed on the substrate layer 10 by coating.
  • the surface of the base material layer 10 is covered with the drug layer 16.
  • covering it is not restricted to the case where it is continuous, and one part may be discontinuous.
  • a part of the cooling agent may penetrate into the inside of the base material layer 10 or the heat generating layer 13 adjacent to the drug layer 16. In this case, for example, the concentration of the cooling agent on the surface of the heat generating layer 13 in contact with the drug layer 16 is the highest.
  • the drug layer 16 can be confirmed by measuring the distribution of the cooling agent in the heat generating layer 13 before the reaction by a known instrumental analysis method.
  • the heat generation part 20 including the drug layer 16 can be analyzed in the cross-sectional direction using a three-dimensional measurement X-ray computed tomography (CT) apparatus, and can be confirmed by performing elemental analysis.
  • CT three-dimensional measurement X-ray computed tomography
  • the drug layer 16 is present on the side of the heat generating portion 20 on the side where the amount of the cooling agent is large, by infrared absorption spectroscopy.
  • menthol 1,8-cineole, menthyl lactate, menthyl acetate, monomenthyl succinate, 3- (l-menthoxy) -1,2-propanediol, and N-ethyl-3-p-menthancarboxamide
  • menthol 1,8-cineole, menthyl lactate, menthyl acetate, monomenthyl succinate, 3- (l-menthoxy) -1,2-propanediol, and N-ethyl-3-p-menthancarboxamide
  • One or two or more compounds selected from the group consisting of it becomes easy to maintain a cold sensation, and it is possible to improve the sensation of a cold sensation by combining an aroma. It is preferable that it is menthol from a viewpoint of raising the comfortable irritation
  • the cooling agent is dissolved in a solvent having a molecular weight of 1,000 or less described later.
  • cooling agent is something which acts on the skin, mucous membrane, etc. of the user to give the user a cold feeling, that is, a cold feeling.
  • the solvent having a molecular weight of 1,000 or less is preferably a polyhydric alcohol, and more preferably one or more selected from polyethylene glycol (PEG), glycerin and propylene glycol.
  • polyethylene glycol is preferable from the viewpoint of maintaining good volatilization of the cooling agent and obtaining good heat buildup, and from the viewpoint of improving the feeling of effect on the application site and obtaining a high immediate effect.
  • the molecular weight of the solvent is 1,000 or less, the viewpoint of obtaining good heat buildup, the viewpoint of being able to reduce the content of the cooling agent as much as possible, and effectively obtaining the comfortable stimulation by the cooling agent, From the viewpoint of maintaining the good volatility of the photosensitive agent, it is preferably 600 or less, and more preferably 450 or less.
  • the lower limit value is not particularly limited, but is preferably 50 or more, and more preferably 100 or more.
  • molecular weight as used in this specification means a weight average molecular weight, when distribution arises in molecular weight like polyethylene glycol.
  • PEG is contained in the heating element 18, the solvent in the heating element 18 is extracted by a solvent extraction method performed when determining the content of the solvent in the heating element 18 described later, and the extract is analyzed by GPC Identify the weight average molecular weight.
  • the content of the solvent having a molecular weight of 1,000 or less from the viewpoint of effectively obtaining a comfortable stimulus by the cooling agent while providing a good feeling of warmth immediately after the start of use, with the cooling agent in the pharmaceutical composition It is preferable that it is 30 mass% or more with respect to the total amount of this solvent, and it is more preferable that it is 50 mass% or more.
  • the content of the solvent having a molecular weight of 1,000 or less is relative to the total amount of the cooling agent and the solvent in the pharmaceutical composition from the viewpoint of imparting a comfortable stimulus by the cooling agent while securing safety.
  • the content is preferably 85% by mass or less, and more preferably 70% by mass or less.
  • the content of the solvent having a molecular weight of 1,000 or less is a heat generating layer from the viewpoint of effectively obtaining a comfortable stimulus by the cooling agent while imparting a good thermal sensation immediately after the start of use. It is preferable that it is 2.0 mg / cm ⁇ 2 > or more per unit area in planar view of 13, and it is more preferable that it is 4.0 mg / cm ⁇ 2 > or more.
  • the content of the solvent having a molecular weight of 1,000 or less per unit area in plan view of the heat generating layer 13 from the viewpoint of providing a comfortable stimulus by the cooling agent while securing safety.
  • the content of the solvent having a molecular weight of 1,000 or less is obtained as a value obtained by dividing the mass of the solvent having a molecular weight of 1,000 or less contained in the heat generating portion 20 by the area of the heat generating layer 13 in plan view. Further, the content of the solvent having a molecular weight of 1,000 or less contained in the heating element 18 can be determined by analyzing and quantifying the extract obtained by the solvent extraction method by gas chromatography. Specifically, the heating element 18 is taken out of the heating tool 1, and the heating element 18 is immersed in a solvent (preferably ethanol), and left sealed at room temperature for 9 hours while being sealed to obtain an extract. Thereafter, the extract obtained is analyzed by gas chromatography.
  • a solvent preferably ethanol
  • the content of the cooling agent relative to the area of the heat generating layer 13 in plan view is preferably 1.0 mg / cm 2 or more, more preferably 1.5 mg / cm 2 from the viewpoint of effectively obtaining a comfortable stimulus by the cooling agent.
  • the above more preferably 1.7 mg / cm 2 or more.
  • the content of the cooling agent relative to the area of the heat generating layer 13 in plan view is preferably from the viewpoint of providing a comfortable stimulus by the cooling agent while maintaining safety, and from the viewpoint of maintaining good heat generation characteristics. 6.0 mg / cm 2 or less, more preferably 4.5 mg / cm 2 or less, more preferably 3.2 g / cm 2 or less.
  • the content of the cooling agent is determined by dividing the amount of the cooling agent contained in the heat generating portion 20 by the area of the heat generating layer 13 in plan view.
  • the amount of cooling agent contained in the heating element 18 is quantified by analyzing the extract obtained by the solvent extraction method by gas chromatography. Specifically, the heating element 18 is taken out of the heating tool 1, the heating element 18 is immersed in a solvent (ethanol is preferred), sealed, and left at room temperature for 9 hours. The extract obtained in this way is analyzed by gas chromatography.
  • the weight ratio of the oxidizable metal to the cooling agent contained in the heating tool 1 is preferably 5 or more and 55 or less, and more preferably 10 or more and 50 or less. More preferably, it is 10 or more and 40 or less.
  • the weight ratio of the oxidizable metal to menthol is preferably 5 or more and 55 or less, more preferably 10 or more and 50 or less, and more preferably 10 or more and 40 or less from the viewpoint of obtaining effect and immediate effect more effectively. It is more preferable that it is the following.
  • the volatilization amount of the cooling agent is, for example, 1 mg / 2 hours or more and 5 mg / 2 hours or less. It is preferably 1.3 mg / 2 hours or more from the viewpoint of obtaining a feeling of effect on pain by a cooling agent and immediate effect, and is preferably 1.7 mg / 2 hours or more from the viewpoint of obtaining a gingin feeling. More preferably, it is 1.9 mg / 2 hours or more.
  • the volatilization amount of the cooling agent is preferably from the viewpoint of providing a comfortable stimulus by the cooling agent while maintaining safety and maintaining good heat generation characteristics to improve the feeling of effect and the immediate effect. It is 3.5 mg / 2 hours or less, more preferably 3.0 mg / 2 hours or less, still more preferably 2.8 mg / 2 hours.
  • the volatilization amount of the cooling agent can be measured as follows. First, a 15 cm ⁇ 25 cm polyvinyl fluoride resin gas collection bag (Tedlar (registered trademark) bag) containing a sufficient amount of air to cause an oxidation reaction between the heating element 18 containing a cooling agent or the heating implement 1. Dupont Co., Ltd. is prepared, one end of the gas collection bag is connected to the air supply source, and the discharge port of the other end is immersed in ethanol at the tip of the tube connected to the discharge port. Next, the heating element 18 or the heating tool 1 containing a cooling agent is taken out from the oxygen blocking bag, put in the gas collecting bag, and placed on a hot plate set at 35 ° C. for 2 hours.
  • Tedlar registered trademark
  • the pharmaceutical composition may contain other components as long as the effects of the present invention are not impaired.
  • the drug composition preferably contains substantially no surfactant.
  • the phrase “not substantially contained in the drug composition” means that the content of the target compound in the drug layer is preferably relative to the total amount of the cooling agent and the solvent having a molecular weight of 1,000 or less. Less than 0.1%, more preferably less than 0.01%, more preferably not contained in the drug layer.
  • the water-retaining layer 19 contains moisture, which enables it to supply thermal steam and maintain its heat generation characteristics well.
  • the content of water contained in the water retention layer 19 is preferably 10 to 45% by mass, more preferably 12 to 40% by mass, and more preferably 13 to 30% by mass of the maximum water absorption amount of the water retention layer 19. Even when the heat generating composition is filled in a large amount in one heat generating portion 20 for some reason or unevenly distributed in a specific place at a large amount at the time of manufacturing the heat generating portion 20, abnormal heat generation is prevented and good. It is further preferable in that the heat generation characteristics can be stably obtained.
  • the content of water contained in the water retention layer 19 is preferably 12% by mass or more of the maximum water absorption amount of the water retention layer 19, and more preferably 13% by mass or more. Moreover, it is preferable that it is 40 mass% or less, and, as for content of the water contained in the water holding layer 19, it is more preferable that it is 30 mass% or less.
  • the maximum water absorption can be measured as follows.
  • the water-retaining layer 19 preferably has water absorbency capable of absorbing and holding 10 to 45% by mass of water of the maximum water absorption amount, regardless of the presence or absence of the air permeability, but preferably the one having the air permeability.
  • the air permeability of the water-retaining layer 19 in the state of absorbing 10 to 45% by mass of the maximum water absorption is preferably 500 seconds / 100 ml or less, and more preferably 1 to 300 seconds / 100 ml. With such an air permeability, air permeability of the heat generating portion 20 is sufficiently ensured, so that oxygen supply is sufficiently obtained, high heat generation efficiency is obtained, and oxidation reaction of the oxidizable metal becomes good. Also, it may be possible to generate a large amount of water vapor. Further, it is more preferably 300 seconds / 100 ml or less, and from the viewpoint of preventing an excessive temperature rise, it is more preferably 1 second / 100 ml or more.
  • FIG. 4 shows an example in which the heat retention layer 13 and the water retention layer 19 are laminated, and the material including the component (a) fiber material and the component (b) water absorbent polymer is used as the water retention layer 19.
  • the water retaining layer 19 is formed of a water absorbing sheet 102.
  • the heat generating layer 13 shows the oxidizable metal (M) and the carbon component (C).
  • the water retention layer 19 may be composed of a sheet containing the component (a), for example, a single fiber sheet, or two or more layers may be laminated.
  • a fiber sheet the paper, the nonwoven fabric manufactured from the fiber material mentioned later, or what laminated paper and a nonwoven fabric etc. are mentioned.
  • the sheet containing the component (a) may be a sheet material such as paper or non-woven fabric in which a fiber material is laminated or laminated on a material having no water absorbency such as polyethylene fiber, polypropylene fiber, polyethylene sheet, polypropylene sheet, It may be a sheet material such as paper making, non-woven fabric, etc., in which another fiber material is laminated or mixed with fiber material such as pulp fiber or rayon fiber.
  • the content of water contained in the water retention layer 19 can be easily adjusted, the water content in the heat generation layer is made appropriate, and good heat buildup and warmth It is preferable from the point of maintaining well.
  • the water retention layer 19 may further contain the component (b).
  • the form of the water retaining layer 19 is (i) one sheet in which the component (a) and the component (b) are uniformly mixed, (ii) the component Among the same or different sheets including (a), those in which the component (b) is disposed, and (iii) those in which the component (b) is dispersed to form a sheet can be exemplified.
  • the water content of the heat generating layer 13 can be easily controlled, the water content of the water holding layer 19 can be easily adjusted, and the preferable amount is the form of (ii) belongs to.
  • the water retention layer 19 of the form of (ii) spreads the component (b) uniformly on the sheet
  • any of hydrophilic fibers and hydrophobic fibers can be used, but it is preferable to use hydrophilic fibers.
  • using cellulose fibers promotes the water transfer to the water retention layer 19, It is more preferable from the point of being easy to adjust the content of the water contained in the water retention layer 19, to make the water content in the heat generating layer appropriate, and to favorably maintain the rise of good heat generation and the warm feeling.
  • a cellulose fiber a chemical fiber (synthetic fiber) or a natural fiber can be used.
  • cellulose fibers for example, rayon and acetate can be used as chemical fibers.
  • natural fibers among cellulose fibers include, for example, various plant fibers, wood pulp fibers, non-wood pulp fibers, cotton fibers, hemp fibers, wheat straw fibers, hemp fibers, jute fibers, kapok fibers, palm fibers, and One or more selected from rag fiber can be used.
  • using wood pulp fibers makes it easy to adjust the content of water contained in the water retaining layer 19, makes the amount of water in the heat generating layer appropriate, and makes the rise of heat generation and the sense of warmth favorable. It is preferable from the point of sustaining.
  • the fiber length of various fiber materials is preferably 0.5 to 6 mm, and more preferably 0.8 to 4 mm.
  • the fiber length of the fiber material is preferably 0.5 mm or more, and more preferably 0.8 mm or more.
  • the fiber length of the fiber material is preferably 6 mm or less, more preferably 4 mm or less.
  • the water-retaining layer 19 may contain hydrophobic fibers, particularly heat-fusible fibers, if necessary.
  • the content of the heat-fusible fiber is preferably 0.1 to 10% by mass, more preferably 0.5 to 5% by mass, with respect to the total amount of fibers in the water retention layer 19.
  • the content of the heat-fusible fiber is preferably 0.1% by mass or more with respect to the total amount of fibers in the water retention layer 19, and more preferably 0.5% by mass or more.
  • the content of the heat-fusible fiber is preferably 10% by mass or less, more preferably 5% by mass or less, based on the total amount of fibers in the water retention layer 19.
  • the content of water contained in the water retention layer 19 by using, as the component (b), a hydrophilic polymer having a crosslinked structure capable of absorbing and holding a liquid 20 times or more its own weight, as in the above component (a) Can be properly adjusted.
  • a shape of a component (b) 1 type (s) or 2 or more types selected from spherical shape, lump shape, grape-tuft shape, and fibrous form are mentioned.
  • the average particle diameter of the component (b) is preferably 1 to 1000 ⁇ m, and more preferably 10 to 500 ⁇ m.
  • the average particle diameter of the component (b) is preferably 1 ⁇ m or more, and more preferably 10 ⁇ m or more.
  • the average particle diameter of the component (b) is preferably 1000 ⁇ m or less, more preferably 500 ⁇ m or less.
  • the average particle diameter of the component (b) is measured by a dynamic light scattering method, a laser diffraction method or the like.
  • component (b) examples include, for example, starch, crosslinked carboxylmethylated cellulose, a polymer or copolymer of acrylic acid or an alkali metal salt of acrylic acid, polyacrylic acid and its salt, and polyacrylate graft weight 1 type, or 2 or more types selected from union are mentioned.
  • polyacrylic acid and its salt and polyacrylate graft polymer such as a polymer or copolymer of acrylic acid or an alkali metal salt of acrylic acid, adjustment of the content of water contained in water retention layer 19 It is preferable from the viewpoint of facilitating peeling, making the amount of water in the heat generating layer appropriate, and maintaining good heat build-up and warm feeling favorably.
  • the proportion of the component (b) in the water retaining layer 19 is preferably 10 to 70% by mass in the dry state, and further 20 to 65% by mass promotes rapid water transfer to the water retaining layer 19
  • the water content of the water retention layer 19 can be easily adjusted, and the amount of water in the heat generation layer can be appropriately adjusted, which is preferable from the viewpoint of maintaining good rising of heat generation and good feeling of warmth.
  • the proportion of the component (b) in the water retaining layer 19 is preferably 10% by mass or more, more preferably 20% by mass or more, and 70% by mass or less in the dry state. It is preferable that it is 65 mass% or less.
  • the water retaining layer 19 is easy to adjust the content of water contained in the water retaining layer 19 and makes the amount of water in the heat generating layer appropriate, and in order to maintain good rising heat generation and a good sense of warmth,
  • the basis weight is preferably 20 to 200 g / m 2 , more preferably 35 to 150 g / m 2 , and still more preferably 50 to 140 g / m 2 .
  • the basis weight of the component (b) contained in the water retention layer 19 makes it easy to adjust the content of water contained in the water retention layer 19, makes the water content in the heat generation layer appropriate, and makes good heat buildup and warmth It is preferably 5 to 150 g / m 2 in a dry state, more preferably 10 to 100 g / m 2 , and still more preferably 30 to 90 g / m 2 from the viewpoint of maintaining excellently.
  • the water retention layer 19 preferably has a basis weight of 20 g / m 2 or more in a dry state, more preferably 35 g / m 2 or more, and still more preferably 50 g / m 2 or more.
  • the water retention layer 19 preferably has a basis weight of 200 g / m 2 or less in a dry state, more preferably 150 g / m 2 or less, and still more preferably 140 g / m 2 or less.
  • the basis weight of the component (b) contained in the water retention layer 19 is preferably 5 g / m 2 or more, more preferably 10 g / m 2 or more, and more preferably 30 g / m 2 or more in the dry state. It is further preferred that The water retention layer 19 preferably has a basis weight of 150 g / m 2 or less in a dry state, more preferably 100 g / m 2 or less, and still more preferably 90 g / m 2 or less.
  • the water retaining layer 19 may have the heat generating layer 13 formed on one side of the water retaining layer 19 as shown in FIG. 4 or may have the heat generating layer 13 formed on both sides of the water retaining layer 19. .
  • the base layer 10 is prepared, and a drug composition containing a cooling agent and a solvent having a molecular weight of 1,000 or less is coated on the base layer 10 to form the drug layer 16.
  • the coating method of the drug composition is not particularly limited, and a die coater, roller coating, screen printing, roller gravure, knife coating, curtain coater, or the like may be used.
  • the viscosity of the drug composition in the vicinity of the coating temperature is preferably 5 to 100 mPa ⁇ s, and it is preferably 10 to 50 mPa ⁇ s from the viewpoint of ease of coating and the spreadability of the chemical solution. preferable.
  • the viscosity under the conditions of 50 ° C. and 50 RH be in the above-mentioned range as a pharmaceutical composition.
  • the measurement of the said viscosity is performed at 60 rpm of rotor rotational speeds using the No. 4 rotor of a Brookfield viscometer.
  • the heat generating layer 13 is a coating layer of the heat generating composition.
  • the coating method of the heat-generating powder water dispersion is not particularly limited, and examples thereof include a die coater and the like.
  • the heat-generating powder water dispersion can be obtained by uniformly dispersing the oxidizable metal, the carbon component, the water-insoluble component and the like by stirring with a stirrer.
  • the heat-generating powder water dispersion may be prepared by mixing all the components mentioned above at one time, the reaction accelerator is previously dissolved in a solution in which a thickener is dissolved in water to prepare an aqueous solution. Then, a pre-mixed oxidizable metal and carbon component may be mixed with the aqueous solution.
  • the water retention layer 19 is formed on the heat generating layer 13, whereby the heat generating portion 20 is manufactured.
  • the formation method of the water holding layer 19 is not specifically limited, For example, you may distribute the layer containing the particle
  • the heat generating portion 20 in which the drug layer 16 is formed between the base layer 10 and the heat generating layer 13 can be manufactured.
  • the heat generating body 18 includes a heat generating portion 20 and an inner bag 17 accommodating the heat generating portion 20 therein.
  • the inner bag 17 is configured by joining the sheet 171 and the peripheral portion of the sheet 172.
  • An area other than the sheet 171 and the peripheral portion of the sheet 172 is a non-joining area, and the heat generating layer 13 is disposed in the non-joining area.
  • the sheet 171 is disposed closer to the skin than the heat generating layer 13 when the user wears the heating implement 1 on the skin.
  • the sheet 171 is a breathable sheet, and the air permeability thereof is preferably 40,000 seconds / 100 ml or less, more preferably 25,000 seconds / 100 ml or less.
  • the air permeability of the sheet 171 is preferably 10 seconds / 100 ml or more, and more preferably 100 seconds / 100 ml or more.
  • the sheet 171 having such an air permeability for example, it is preferable to use a porous sheet made of a synthetic resin having moisture permeability but not water permeability. Specifically, a film obtained by containing calcium carbonate or the like in polyethylene and stretched can be used.
  • the sheet 172 When the user wears the heating tool 1 on the skin, the sheet 172 is located on the side farther than the heat generation layer 13 than the skin. It is preferable that the air permeability of the sheet 172 be higher than the air permeability of the sheet 171 from the viewpoint of facilitating the release of steam to the outside of the sheet 171.
  • the air permeability of the sheet 172 is preferably 150,000 seconds / 100 ml or less, more preferably 100,000 seconds / 100 ml or less, from the viewpoint of capturing oxygen little by little and maintaining good heat generation characteristics, and more preferably 85,000 seconds. It is more preferable that the amount be less than / 100 ml.
  • 50,000 seconds / 100 ml or more is preferable, and 60,000 seconds / 100 ml or more is more preferable.
  • the sheet 172 having such air permeability for example, it is preferable to use a porous sheet made of a synthetic resin having moisture permeability but not water permeability. Specifically, a film obtained by containing calcium carbonate or the like in polyethylene and stretched can be used.
  • the breathability of the entire sheet layer configured of the second sheet 12 and the sheet 172 is configured of the first sheet 11, the sheet 171, and the base material layer 10. Is lower than the breathability of the entire sheet layer.
  • the second sheet 12 is the outermost layer
  • the air permeability of the entire sheet layer from the second sheet 12 to the heat generating layer 13 is the first sheet 11 as the outermost layer
  • the first sheet 11 to the heat generating layer 13 It is higher than the air permeability of the entire sheet layer.
  • the air permeability of the entire sheet layer from the second sheet 12 to the heat generating layer 13 is preferably 80,000 seconds / 100 ml or more.
  • planar shape of the heat generating body 18 is preferably a rectangular shape, more preferably a square shape.
  • the heating element 18 is housed inside an outer bag formed of the first sheet 11 and the second sheet 12. Further, a part of the sheet 172 of the heat generating body 18 may be fixed to the second sheet 12 by an adhesive such as a hot melt adhesive. Thus, movement of the heat generating body 20 can be suppressed in the outer bag.
  • the surface maximum temperature of the heat generating body 18 is preferably 36 ° C. or more, more preferably 38 ° C. or more, and still more preferably 41 ° C., from the viewpoint of achieving both warmth and coolness comfortable for the user. It is above. Further, the surface maximum temperature of the heating element 18 is preferably 60 ° C. or less, more preferably 55 ° C. or less, and still more preferably 50 ° C. or less, from the viewpoint of giving a comfortable warmth to the user. The surface maximum temperature can be measured using a measuring device in accordance with JIS S4100.
  • the heating implement 1 has a laterally long shape having a longitudinal direction X and a width direction Y orthogonal to the longitudinal direction X in a plan view from the first sheet 11 side. As described above, by making the heating tool 1 into a horizontally long flat shape in plan view from the first sheet 11 side, the heating tool 1 can be attached so as to extend in the left-right direction of the user it can.
  • first sheet 11 and the second sheet 12 may be configured as separate sheets, and the outer peripheral edge may be pasted together to configure a bag body.
  • second sheet 12 may be configured as a series of sheets, the series of sheets may be folded, and the bag body may be configured by bonding the opposing outer peripheral edges to each other.
  • the first sheet 11 is positioned on the skin side of the user when the user wears the heating implement 1.
  • the first sheet 11 is a breathable sheet, and the air permeability thereof is 8000 seconds / 100 ml or less.
  • the air permeability of the first sheet 11 is 6,000 seconds / 100 ml or less and 1,000 seconds / 100 ml or less Is more preferred.
  • the lower limit value of the air permeability of the first sheet 11 is not particularly limited. However, in consideration of the basis weight and the like for preventing the inner bag 17 positioned inside the first sheet 11 from being seen through, in particular, it is preferably 1 second / 100 ml or more.
  • a fiber sheet including non-woven fabric can be used as the first sheet 11.
  • the second sheet 12 is configured of a sheet having the same air permeability as the first sheet 11.
  • the heating tool 1 may be configured to be extensible and contractable at least in the X-axis direction.
  • the first sheet 11 and the second sheet 12 may be the above-described breathable and stretchable sheets that expand and contract in the X-axis direction.
  • the stretch sheet include synthetic fibers selected from polyesters such as polyethylene terephthalate (PET), polyolefins such as polyethylene (PE) and polypropylene (PP), polyamides, polyacrylics, etc .; cellulose, silk, cotton, wool, etc.
  • the stretch sheet is selected from air through method, spun bond method, needle punch method, melt blown method, card method, heat fusion method, water entanglement method, solvent adhesion method using two or more kinds of fibers.
  • Nonwoven fabrics produced by the method can also be used.
  • non-woven fabrics knitted fabrics can also be used.
  • the non-woven fabric having elasticity an air through non-woven fabric or a spun-bonded non-woven fabric containing elastic fibers (for example, polyurethane, polyester) as constituent fibers is preferable, and from the viewpoint of texture the non-woven fabric is surface-treated with silicone or surfactant It can also be used.
  • the first sheet 11 and the second sheet 12 may be stretchable sheets made of the same material, or may be stretchable sheets made of different materials.
  • the first adhesive layer 14 and the second adhesive layer 15 are provided on the outer surface of the first sheet 11.
  • the first adhesive layer 14 and the second adhesive layer 15 are for attaching the heating implement 1 to the skin of the user.
  • the first adhesive layer 14 is a pair, and the pair of first adhesive layers 14 extend in one direction parallel to the outer surface of the first sheet 11 and are spaced apart, preferably in the X-axis direction of the first sheet 11 Are arranged at the ends of the In a plan view from the outer surface side of the first sheet 11, the pair of first adhesive layers 14 preferably do not overlap with the heat generating layer 13 from the viewpoint of heat generation characteristics.
  • the second adhesive layer 15 is disposed in the region between the pair of first adhesive layers 14 in a plan view from the first sheet 11 side, and extends in the same direction following the first adhesive layers 14. There is.
  • the second adhesive layer 15 has a rectangular shape in plan view from the first sheet side.
  • the first adhesive layer 14 and the second adhesive layer 15 are formed by applying an adhesive containing at least one or more selected from an acrylic resin, a vinyl acetate resin, and an olefin resin to the outer surface of the first sheet 11 It is formed.
  • the above-mentioned heating implement 1 be enclosed in an oxygen barrier bag.
  • the oxygen barrier bag is opened and the heating tool 1 is taken out. Thereafter, the release paper 21 is removed, and the heating implement 1 is attached to the back side of the user's neck by the first adhesive layer 14 and the second adhesive layer 15. As a result, the heating implement 1 is fixed to the user.
  • the oxidizable metal in the heat generating layer 13 contacts air, the oxidizable metal is oxidized and the heat generating layer 13 generates heat. As the heat generating layer 13 generates heat, the water in the heat generating layer 13 evaporates to generate steam. The vapor is released to the outside of the heating implement 1 through the base material layer 10, the sheet 171, and the first sheet 11. In addition, when the base material layer 10 is not provided in the heat generating body, the vapor is released to the outside through the sheet 171 and the first sheet 11. On the other hand, since the sheet 172 of the inner bag 17 is a non-ventilated layer, the steam generated in the heat generating layer 13 is blocked by the sheet 172 and hardly released from the second sheet 12 to the outside. Thereby, the steam can be released preferentially from the sheet 171, and the steam can be reliably supplied to the skin of the user.
  • the heating implement 1 appropriately makes the volatilization behavior of the cooling agent with respect to the heat generation behavior, which is the idea of the present inventors, and the effect thereof will be described.
  • the heating tool 1 of the present invention does not uniformly spread the cooling agent over the entire heating portion with a solvent or surfactant like the heating tool described in Patent Document 1, but generates heat.
  • the drug layer 16 is provided separately from the layer 13.
  • the medicine layer 16 being arrange
  • the rise of the heat generation temperature as described above becomes favorable, and the speed of rise of the heat generation temperature and the speed of the initial volatilization rate of the cooling agent are appropriate. It is considered to be a combination of In the present invention, in addition to this, the effect of improving the volatilization amount of the cooling agent is also obtained, and by combining all of them, the sense of effect on the application site of coli, fatigue and pain is improved, and the immediate effect is high. It is estimated that the effect which can not be obtained conventionally can be obtained. Furthermore, a gingin sensation can be obtained by the cooling agent, and the user's satisfaction is enhanced.
  • the details of the mechanism by which the volatilization behavior of the cooling agent can be controlled by using a solvent having a molecular weight of 1,000 or less is unclear, but the higher the molecular weight of the solvent, the more the solvent becomes an oxidizable metal in the heat generating layer 13 As a result of acting on the carbon component to easily inhibit the oxidation reaction, the rising temperature at the onset of heat generation of the heating tool 1 is decreased, while the molecular weight of the solvent is reduced to 1,000 or less. It is believed that the decrease can be suppressed as well as the decrease in the volatilization amount and rate of the cooling agent.
  • the cooling agent is adsorbed to the water retention layer 19 between the heat generating layer 13 and the first sheet by arranging the drug layer 16 between the heat generating layer 13 and the second sheet 12. It can suppress that the water retention capacity of the water retention layer 19 falls. As a result, good heat generation can be stably obtained. Further, by arranging the drug layer 16 between the heat generating layer 13 and the second sheet 12, the adhesiveness of the first adhesive layer 14 and the second adhesive layer 15 disposed on the first sheet 11 can be favorably maintained. . In other words, it is possible to suppress that the cooling agent exuded from the drug layer 16 acts on the first adhesive layer 14 and the second adhesive layer 15 to reduce the adhesiveness.
  • the sheet 172 is the non-permeable layer in the above embodiment, for example, either one of the second sheet 12 and the sheet 172 may be the non-permeable layer, or both may be the non-permeable layer. .
  • a non-air-permeable sheet may be disposed inside the inner bag 17.
  • a non-air-permeable sheet is disposed closer to the sheet 172 than the heat generating layer 13.
  • the non-air-permeable sheet preferably covers the entire heat generating layer 13 in a plan view from the second sheet 12 side.
  • the second sheet 12 and the sheet 172 may be non-ventilated layers or ventilated layers.
  • both ends of the first adhesive layer 14 and both ends of the second adhesive layer 15 reach the outer peripheral edge of the first sheet 11 in plan view from the first sheet side.
  • it is not limited to this.
  • the heating implement 1 may have other fixing portions, such as installing stretchable ear hooks at both ends of the heating implement 1.
  • the heat-generating layer 13 was accommodated in the inner bag 17, the inner bag 17 may not be.
  • the first sheet 11 may be included, and the ventilation layer for supplying air to the heat generating layer 13 may be configured of one first sheet 11.
  • the configuration of the heating tool can be simplified.
  • the heating implement 1 was stuck on the back side of the neck, you may stick not only to this but on the skin surface of the other site
  • the present invention further discloses the following heating implement regarding the embodiment mentioned above.
  • the heating agent, wherein the drug layer comprises a drug composition containing a cooling agent and a solvent having a molecular weight of 1,000 or less.
  • the heating implement according to ⁇ 1> having a water retention layer between the heat generation layer and the first sheet.
  • the cooling agent is preferably menthol, 1,8-cineole, menthyl lactate, menthyl acetate, monomenthyl succinate, 3- (l-menthoxy) -1,2-propanediol, and N-ethyl-3-p.
  • the content of the solvent is preferably 30% by mass or more and 85% by mass or less based on the total amount of the cooling agent and the solvent in the pharmaceutical composition. The heating implement as described in any one.
  • ⁇ 5> The heating implement according to any one of ⁇ 1> to ⁇ 4>, wherein the solvent preferably contains a polyhydric alcohol.
  • the solvent is preferably one or more selected from polyethylene glycol, glycerin and propylene glycol.
  • ⁇ 7> The heating implement according to any one of ⁇ 1> to ⁇ 6>, wherein the molecular weight of the solvent is preferably 600 or less.
  • a content of the cooling agent with respect to an area in plan view of the heat generating layer is preferably 1.0 mg / cm 2 or more.
  • ⁇ 9> Content relative to the area in plan view of the heat generating layer of the cooling agent preferably is 6.0 mg / cm 2 or less, ⁇ 1> to warming device according to any one of ⁇ 8>.
  • a content of the solvent is preferably 20.0 mg / cm 2 or less per unit area of the heat generating layer in a plan view.
  • ⁇ 12> The heating implement according to any one of ⁇ 1> to ⁇ 11>, wherein the pharmaceutical composition is preferably substantially free of a surfactant.
  • the heat generating layer preferably comprises an oxidizable metal, a water absorbing agent, and water.
  • the heat generating layer preferably contains a thickener.
  • the oxidizable metal is represented by a basis weight, preferably 100 g / m 2 or more and 3,000 g / m 2 or less.
  • the heat generating layer is preferably a coating layer of a heat generating composition.
  • the air permeability from the heat generating layer to the second sheet is preferably 80,000 seconds / 100 ml or more.
  • the heat generating portion has an inner bag, and among the sheets constituting the inner bag, the air permeability of the sheet disposed on the side farther from the skin than the heat generating layer is arranged closer to the skin than the heat generating layer.
  • the air permeability of the sheet disposed on the skin side of the heat generating layer is preferably 40,000 seconds / 100 ml or less and 10 seconds / 100 ml or more, according to ⁇ 18>.
  • the air permeability of the sheet disposed on the side farther from the skin than the heat generating layer is preferably 50,000 seconds / 100 ml or more and 150,000 seconds / 100 ml or less.
  • the heating element is laminated in the order of the base material layer, the drug layer, and the heat generating layer, and the base material layer is disposed to be located on the side farther from the skin than the heat generating layer ⁇ 1> to ⁇ 20>
  • a heat generating body is laminated in the order of the base material layer, the drug layer, the heat generation layer, and the water retention layer, and the base material layer is disposed to be farther from the skin than the heat generation layer, the water retention layer
  • the heating implement according to any one of ⁇ 2> to ⁇ 21>, which is disposed so as to be located on the skin side of the heat generating layer.
  • ⁇ 23> The heating implement according to any one of ⁇ 1> to ⁇ 22>, wherein the volatilization amount of the cooling agent after the start of heat generation of the heat generation layer is preferably 1 mg / 2 hours or more and 5 mg / 2 hours or less.
  • ⁇ 25> The heating implement according to any one of ⁇ 1> to ⁇ 24>, preferably having an adhesive layer on the side opposite to the heat generating layer side of the first sheet.
  • a breathable first sheet The second sheet, A heat generating layer disposed between the first sheet and the second sheet; A drug layer disposed between the heat generating layer and the second sheet; Equipped with A heating element is laminated in order of a base material layer, the drug layer, and the heat generating layer, The base material layer is disposed to be farther from the skin than the heat generating layer, The air permeability from the heat generating layer to the first sheet is configured to be higher than the air permeability from the heat generating layer to the second sheet,
  • the drug layer contains menthol as a cooling agent, and comprises a drug composition containing menthol and a solvent having a molecular weight of 1,000 or less, The said solvent is 30 mass% or more and 85 mass% or less with respect to the total amount of the said cooling agent and the said solvent,
  • the heating implement wherein the weight ratio of the cooling agent to the metal to be oxidized contained in the heat generating layer is 5 or more and 55 or less.
  • ⁇ 27> It is a usage method of the heating implement in any one of ⁇ 1> thru
  • ⁇ 28> The usage method of a heating implement as described in ⁇ 27> which applies thermal steam to a user's skin.
  • a heating tool having a structure as shown in FIG. 1 was produced as follows.
  • Example 1 [Preparation of Heated Powder Water Dispersion] 100 parts by mass of an oxidizable metal, 8 parts by mass of a carbon component, 62 parts by mass of water, 11 parts by mass of a reaction accelerator, and 0.2 parts by mass of a thickener were prepared and adjusted in the following procedure.
  • a thickener is dissolved in water, then a reaction accelerator is dissolved to prepare an aqueous solution, while a powder in which an oxidizable metal and a carbon component are pre-mixed is prepared, and the pre-mixed powder is added to the aqueous solution, The mixture was stirred for 10 minutes at 150 rpm with a disk turbine type stirring blade to obtain a slurry of a heat-generating powdery water dispersion.
  • Oxidizable metal Iron powder (iron powder RKH, average particle diameter 45 ⁇ m, manufactured by Dowa IP Creation Ltd.) Carbon component: Activated carbon (Carborafin, average particle size 40 ⁇ m, manufactured by Nippon Envirochemicals Co., Ltd.)
  • Water Tap water reaction promoter: Sodium chloride (general method sodium chloride, manufactured by Otsuka Chemical Co., Ltd.) Thickener: Xanthan gum (Echo Gum BT, DSP Gokyo Food & Chemical Co., Ltd.)
  • a solvent in which a cooling agent is dissolved according to the composition shown in Table 1 is applied (coating amount 60 g / m 2 ), and the above heat is generated on the coated surface.
  • the powder water dispersion was applied in the range of 25 cm 2 (5 cm ⁇ 5 cm) in an amount of 600 g / m 2 .
  • the above-described polymer sheet was disposed on the formed heat generating layer to produce a heat generating portion which is a laminated structure.
  • the air permeability of the first sheet (air permeable sheet placed on the skin side) is 16,000 seconds / 100 ml
  • the air permeability of the second sheet (non air permeable sheet) is 80,000 seconds / 100 ml or more
  • the heat generating part was put in a certain inner bag, and the peripheral part was hermetically sealed. At this time, the heat generating layer was disposed such that the substrate layer side was positioned on the second sheet side. Thus, a heating element was obtained.
  • Needle punched non-woven fabric (air permeability 1 second / 100 ml, basis weight 80 g / m 2 ) is used as the first sheet, and spun bonded non-woven fabric (air permeability 1 second / 100 ml, basis weight 38 g / m 2 ) as the second sheet It was used.
  • two heating elements were spaced apart and arrange
  • Examples 2 to 8 A heating tool was obtained in the same manner as in Example 1 except that the cooling agent and the solvent having the composition shown in Table 1 were used.
  • a raw material composition is as follows. ⁇ Composition of raw material composition> ⁇ Oxidizable metal: Iron powder, manufactured by Dowa IP Creation Co., Ltd., trade name "RKH”: 83% -Fibrous material: Pulp fiber (Fletcher Challenge Canada, trade name: NBKP "Mackenzi (adjusted to 200 ml of CSF)"): 8% ⁇ Reaction accelerator: Activated carbon (made by Nippon Enviro Chemicals Co., Ltd., trade name "Carborafin", average particle diameter 45 ⁇ m) 9%
  • the obtained molded sheet was cut into 49 mm ⁇ 49 mm, three sheets were stacked, and the electrolytic solution was injected so that the amount of the electrolytic solution (5% saline solution) was 45 parts with respect to 100 parts of the molded sheet. Then, the solvent which melt
  • Comparative Example 3 A heating tool was obtained in the same manner as in Example 1 except that the cooling agent and the solvent having the composition shown in Table 1 were used, and the cooling agent was positioned as shown in Table 1. Specifically, after applying the above-mentioned heat-generating powdery water dispersion on a 25 cm 2 (5 cm ⁇ 5 cm) polyethylene laminated paper in an amount of 600 g / m 2 in the range of 25 cm 2 (5 cm ⁇ 5 cm) The solvent which dissolved the cooling agent by composition shown in Table 1 is applied (coating amount 60 g / m 2 ), the above-mentioned polymer sheet is arranged on the application side, and the exothermic part which is a lamination structure is produced. did.
  • Comparative Example 4 A heating tool was obtained in the same manner as in Example 1 except that the cooling agent and the solvent having the composition shown in Table 1 were used, and the cooling agent was positioned as shown in Table 1. Specifically, after applying the above-mentioned heat-generating powdery water dispersion on a 25 cm 2 (5 cm ⁇ 5 cm) polyethylene laminated paper in an amount of 600 g / m 2 in the range of 25 cm 2 (5 cm ⁇ 5 cm) Then, the above-mentioned polymer sheet is disposed on the coated surface, and a solvent in which the cooling agent is dissolved with the composition shown in Table 1 is coated thereon (coating amount 60 g / m 2 ) to produce a laminated structure And the heat generating portion was produced.
  • Comparative Example 5 A heating tool was obtained in the same manner as in Example 1 except that the cooling agent and the solvent having the composition shown in Table 1 were used.
  • Heat generation characteristics (rise of heat generation in the early stage of application)
  • a temperature sensor of the measuring device is attached to the center of the surface of the first sheet of the heating tool with the heat generating part using a measuring device in accordance with JIS S4100, room temperature 20 ° C., absolute humidity 50%, The heat generation of the heat generating portion was started in the presence of oxygen, and the time (minute) required to reach 42 ° C. for feeling a comfortable warm feeling was measured.
  • a 15 cm x 25 cm polyvinyl fluoride resin gas collection bag (Tedlar (registered trademark) bag, manufactured by DuPont) containing a sufficient amount of air enough to cause an oxidation reaction of the heating element is prepared. Then, one end of the gas collection bag was connected to an air supply, and the discharge port at the other end or the tip of a tube connected to the discharge port was immersed in ethanol. Next, the heating element holding menthol was removed from the oxygen blocking bag, placed in the gas collection bag, and placed on a hot plate set at 35 ° C. for 2 hours.
  • the heating element was taken out from the gas collection bag, the inside of the gas collection bag was washed with ethanol, ethanol used for washing was also collected, and the total amount of menthol was volatilized.
  • the analysis of the collected amount of menthol was performed by gas chromatography (Agilent 6890N, manufactured by Agilent Technologies, Inc.). All these operations were performed under atmospheric pressure. Since two heating elements were used for the heating tool, the amount of menthol volatilization of the heating tool was twice the amount measured per heating element.
  • Example 3 since Example 3 uses PEG 400, the rise time at 42 ° C. and the amount of menthol volatilization are further improved by volatilization as compared with Example 8 using PEG 1000. As a result, it is considered that the feeling of effect on pain, the immediate effect, and the feeling of menthol are even better. That is, it is presumed that the effect of the present invention can be easily obtained by lowering the molecular weight of the solvent. In addition, in Comparative Example 3, since the rise time at 42 ° C. was long, no immediate effect was obtained, and the menthol feeling was also weak.
  • Comparative Example 4 the temperature did not rise up to 42 ° C., and therefore the sense of effect on pain, the immediate effect, and the feeling of menthol were all inadequate.
  • the heating implement of Example 1 when polyethylene glycol having a molecular weight of 2000 is used, the amount of menthol volatilized does not reach 1 mg / 2 hours and is inferior in any of the feeling of effect, immediate effect, and gingin feeling.

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Abstract

La présente invention concerne un outil de chauffage (1) qui est pourvu: d'une première feuille (11) perméable à l'air; d'une seconde feuille (12); d'une couche de génération de chaleur (13) qui est interposée entre la première feuille (11) et la seconde feuille (12); et d'une couche de médicament (16) qui est interposée entre la couche de génération de chaleur (13) et la seconde feuille (12), l'outil de chauffage étant configuré de telle sorte que la perméabilité à l'air à partir de la couche de génération de chaleur (13) à la première feuille (11) est supérieure à celle de la couche de génération de chaleur (13) à la seconde feuille (12). La couche de médicament (16) comprend une composition de médicament comprenant un agent de sensation de refroidissement et un solvant ayant un poids moléculaire d'au plus 1000, et la quantité de volatilisation de l'agent de sensation de refroidissement après l'initiation de la génération de chaleur dans la couche de génération de chaleur (13) est de 1 à 5 mg/2 heures.
PCT/JP2018/030926 2017-08-23 2018-08-22 Outil de chauffage WO2019039497A1 (fr)

Priority Applications (1)

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CN201880054217.7A CN111031973A (zh) 2017-08-23 2018-08-22 温热器具

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