WO2019033362A1 - Dispositif de prélèvement sanguin et appareil de commande associé - Google Patents
Dispositif de prélèvement sanguin et appareil de commande associé Download PDFInfo
- Publication number
- WO2019033362A1 WO2019033362A1 PCT/CN2017/097928 CN2017097928W WO2019033362A1 WO 2019033362 A1 WO2019033362 A1 WO 2019033362A1 CN 2017097928 W CN2017097928 W CN 2017097928W WO 2019033362 A1 WO2019033362 A1 WO 2019033362A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- blood collection
- blood
- microneedle
- microneedle assembly
- anesthetic
- Prior art date
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 300
- 239000008280 blood Substances 0.000 title claims abstract description 299
- 230000003444 anaesthetic effect Effects 0.000 claims abstract description 87
- 238000003860 storage Methods 0.000 claims abstract description 84
- 210000003491 skin Anatomy 0.000 claims abstract description 49
- 230000033001 locomotion Effects 0.000 claims abstract description 28
- 210000002615 epidermis Anatomy 0.000 claims abstract description 25
- 238000004891 communication Methods 0.000 claims abstract description 7
- 239000003814 drug Substances 0.000 claims description 29
- 229940079593 drug Drugs 0.000 claims description 23
- 230000002441 reversible effect Effects 0.000 claims description 8
- 238000003825 pressing Methods 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 230000004913 activation Effects 0.000 claims description 3
- 230000007246 mechanism Effects 0.000 claims description 3
- 238000012546 transfer Methods 0.000 claims description 3
- 230000009977 dual effect Effects 0.000 claims description 2
- 230000001681 protective effect Effects 0.000 claims description 2
- 238000013022 venting Methods 0.000 claims description 2
- 230000000712 assembly Effects 0.000 claims 1
- 238000000429 assembly Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 21
- 230000036407 pain Effects 0.000 abstract description 15
- 230000008569 process Effects 0.000 abstract description 13
- 206010002091 Anaesthesia Diseases 0.000 abstract description 11
- 230000037005 anaesthesia Effects 0.000 abstract description 11
- 210000004207 dermis Anatomy 0.000 abstract description 11
- 238000004080 punching Methods 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 21
- 239000000758 substrate Substances 0.000 description 14
- 238000007789 sealing Methods 0.000 description 11
- 239000003193 general anesthetic agent Substances 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 238000003466 welding Methods 0.000 description 6
- 238000001467 acupuncture Methods 0.000 description 4
- 239000003146 anticoagulant agent Substances 0.000 description 4
- 229940127219 anticoagulant drug Drugs 0.000 description 4
- 238000003491 array Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000000428 dust Substances 0.000 description 4
- 206010072170 Skin wound Diseases 0.000 description 3
- 239000000356 contaminant Substances 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000010241 blood sampling Methods 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000012943 hotmelt Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229940124549 vasodilator Drugs 0.000 description 2
- 239000003071 vasodilator agent Substances 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 206010011469 Crying Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000013100 final test Methods 0.000 description 1
- -1 for example Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
Definitions
- a housing, the bottom plate of the housing is provided with an array of micro pinholes
- FIG. 13 is a schematic structural diagram of a bottom plate of a blood collection device according to an embodiment of the present invention.
- the two sides of the second baffle 24 are provided with a drug storage cavity 221 and a blood storage cavity 224; wherein the drug storage cavity 221 can be used for storing blood for assisting blood collection.
- Agents for example, vasodilators, anticoagulants, and the like.
- the blood collection due to the action of platelets or coagulation factors, it is easy to cause the blood at the wound of the skin to coagulate or block the microneedle - affecting the progress of blood collection; however, injecting the auxiliary agent at the same time of blood collection can ensure the normal blood collection. get on.
- the second microneedle assembly 2 is pressed against the skin tissue of the human body, and the two-pass microneedle 211 in the second microneedle assembly 2 is inserted into the dermis layer of the human skin.
- the pressure ⁇ pressing the first set of hangers 73 and/or the elastic hangers 74 is released, they can return to the position before the initial pressing by the elastic restoring force generated by themselves, and drive the first microneedle assembly 1 and/or the second micro.
- the needle assembly 2 is placed away from the skin tissue of the blood donor.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
L'invention concerne un dispositif de prélèvement sanguin et un appareil de commande associé, ceux-ci étant applicables dans le domaine des instruments médicaux. Le dispositif de prélèvement sanguin comprend : un premier ensemble micro-aiguille (1) présentant un canal d'administration d'anesthésique; un deuxième ensemble micro-aiguille (2) présentant un canal de prélèvement sanguin; une première structure de déplacement (3) pour entraîner le premier ensemble micro-aiguille (1) en vue d'injecter un anesthésique dans l'épiderme; une deuxième structure de déplacement (4) pour entraîner le deuxième ensemble micro-aiguille (2) en vue de prélever le sang provenant de la peau; et une structure de stockage de sang (5) en communication avec le deuxième ensemble micro-aiguille (2) et utilisée pour stocker le sang prélevé. Dans le dispositif de prélèvement sanguin, un réseau de micro-aiguilles est formé d'une pluralité de micro-aiguilles, présentant un micro-diamètre, distribuées de manière ordonnée, de telle sorte qu'une plaie provoquée par la perforation de la peau par les micro-aiguilles est à l'échelle micrométrique; et pendant le procédé de prélèvement sanguin, la profondeur perforée par les micro-aiguilles peut être régulée avec précision. Lorsque les micro-aiguilles perforent l'épiderme de la peau, l'anesthésique est administré et après l'anesthésie, les micro-aiguilles perforent le derme pour aspirer le sang. Pendant l'ensemble du procédé, un patient ne ressentira pas de douleur, ce qui permet de réaliser un prélèvement sanguin indolore.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2017/097928 WO2019033362A1 (fr) | 2017-08-17 | 2017-08-17 | Dispositif de prélèvement sanguin et appareil de commande associé |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2017/097928 WO2019033362A1 (fr) | 2017-08-17 | 2017-08-17 | Dispositif de prélèvement sanguin et appareil de commande associé |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2019033362A1 true WO2019033362A1 (fr) | 2019-02-21 |
Family
ID=65362104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2017/097928 WO2019033362A1 (fr) | 2017-08-17 | 2017-08-17 | Dispositif de prélèvement sanguin et appareil de commande associé |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2019033362A1 (fr) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030199812A1 (en) * | 1999-09-22 | 2003-10-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
| US20070275521A1 (en) * | 2006-05-26 | 2007-11-29 | Chien-Chung Fu | Method of manufacturing hollow micro-needle structures |
| CN101553266A (zh) * | 2006-11-24 | 2009-10-07 | 厄弗翁简易股份公司 | 医用自动微型注射器和取样器装置 |
| US20120058506A1 (en) * | 2009-04-20 | 2012-03-08 | Teknologian Tutkimuskeskus Vtt | Microneedle |
| CN102811754A (zh) * | 2010-01-13 | 2012-12-05 | 第七感生物系统有限公司 | 流体的快速输送和/或抽出 |
| US20150208984A1 (en) * | 2014-01-28 | 2015-07-30 | Micro Nipple Technology Co., Ltd. | Transdermal microneedle continuous monitoring system |
| CN105722461A (zh) * | 2013-09-26 | 2016-06-29 | P·勒尔 | 采血装置 |
| CN205360234U (zh) * | 2015-12-22 | 2016-07-06 | 无锡吉迈微电子有限公司 | 自行载药的长时透皮给药及取样装置 |
| CN206391365U (zh) * | 2016-06-29 | 2017-08-11 | 莆田学院 | 一种穿戴式微针给药装置 |
-
2017
- 2017-08-17 WO PCT/CN2017/097928 patent/WO2019033362A1/fr active Application Filing
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030199812A1 (en) * | 1999-09-22 | 2003-10-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
| US20070275521A1 (en) * | 2006-05-26 | 2007-11-29 | Chien-Chung Fu | Method of manufacturing hollow micro-needle structures |
| CN101553266A (zh) * | 2006-11-24 | 2009-10-07 | 厄弗翁简易股份公司 | 医用自动微型注射器和取样器装置 |
| US20120058506A1 (en) * | 2009-04-20 | 2012-03-08 | Teknologian Tutkimuskeskus Vtt | Microneedle |
| CN102811754A (zh) * | 2010-01-13 | 2012-12-05 | 第七感生物系统有限公司 | 流体的快速输送和/或抽出 |
| CN105722461A (zh) * | 2013-09-26 | 2016-06-29 | P·勒尔 | 采血装置 |
| US20150208984A1 (en) * | 2014-01-28 | 2015-07-30 | Micro Nipple Technology Co., Ltd. | Transdermal microneedle continuous monitoring system |
| CN205360234U (zh) * | 2015-12-22 | 2016-07-06 | 无锡吉迈微电子有限公司 | 自行载药的长时透皮给药及取样装置 |
| CN206391365U (zh) * | 2016-06-29 | 2017-08-11 | 莆田学院 | 一种穿戴式微针给药装置 |
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