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WO2018185201A3 - Mikroskopanordnung zur aufnahme und darstellung dreidimensionaler bilder einer probe - Google Patents

Mikroskopanordnung zur aufnahme und darstellung dreidimensionaler bilder einer probe Download PDF

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Publication number
WO2018185201A3
WO2018185201A3 PCT/EP2018/058678 EP2018058678W WO2018185201A3 WO 2018185201 A3 WO2018185201 A3 WO 2018185201A3 EP 2018058678 W EP2018058678 W EP 2018058678W WO 2018185201 A3 WO2018185201 A3 WO 2018185201A3
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WO
WIPO (PCT)
Prior art keywords
sample
dimensional images
microscope assembly
displaying
capturing
Prior art date
Application number
PCT/EP2018/058678
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English (en)
French (fr)
Other versions
WO2018185201A2 (de
Inventor
Ilja KARANIN
Alexander Gaiduk
Original Assignee
Carl Zeiss Microscopy Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carl Zeiss Microscopy Gmbh filed Critical Carl Zeiss Microscopy Gmbh
Priority to JP2019546808A priority Critical patent/JP6921973B2/ja
Priority to US16/496,609 priority patent/US20200371338A1/en
Priority to CN201880019344.3A priority patent/CN110431465B/zh
Publication of WO2018185201A2 publication Critical patent/WO2018185201A2/de
Publication of WO2018185201A3 publication Critical patent/WO2018185201A3/de

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    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/20—Surgical microscopes characterised by non-optical aspects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00—Measuring arrangements characterised by the use of optical techniques
    • G01B11/24—Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/04—Measuring microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/368—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements details of associated display arrangements, e.g. mounting of LCD monitor
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T17/00—Three dimensional [3D] modelling, e.g. data description of 3D objects
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/01—Head-up displays
    • G02B27/017—Head mounted
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B30/00—Optical systems or apparatus for producing three-dimensional [3D] effects, e.g. stereoscopic images
    • G02B30/50—Optical systems or apparatus for producing three-dimensional [3D] effects, e.g. stereoscopic images the image being built up from image elements distributed over a 3D volume, e.g. voxels
    • G02B30/56—Optical systems or apparatus for producing three-dimensional [3D] effects, e.g. stereoscopic images the image being built up from image elements distributed over a 3D volume, e.g. voxels by projecting aerial or floating images

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Computer Graphics (AREA)
  • Geometry (AREA)
  • Software Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Microscoopes, Condenser (AREA)
  • Instruments For Measurement Of Length By Optical Means (AREA)
  • Length Measuring Devices By Optical Means (AREA)

Abstract

Die vorliegende Erfindung betrifft eine Mikroskopanordnung (01) zur dreidimensionalen Aufnahme einer zu mikroskopierenden Probe und zur Darstellung dreidimensionaler Bilder der mikroskopierten Probe. Die Mikroskopanordnung (01) umfasst eine Bildaufnahmeeinheit (02) zur Ermittlung von Aufnahmen der Probe und eine Bildverarbeitungseinheit (03) zur Erzeugung dreidimensionaler Bilder der Probe aus den Aufnahmen der Bildaufnahmeeinheit (02). Die Mikroskopanordnung (01) umfasst weiterhin mindestens eine Anzeigeeinheit (04) zum dreidimensionalen Darstellen der erzeugten dreidimensionalen Bilder der Probe. Erfindungsgemäß ist die Mikroskopanordnung (01) zur Erzeugung und zum Darstellen der dreidimensionalen Bilder der Probe mit einer Bildwiederholfrequenz von mindestens 1 Bild pro Sekunde konfiguriert.
PCT/EP2018/058678 2017-04-07 2018-04-05 Mikroskopanordnung zur aufnahme und darstellung dreidimensionaler bilder einer probe WO2018185201A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2019546808A JP6921973B2 (ja) 2017-04-07 2018-04-05 試料の三次元画像を撮影および表示するための顕微鏡装置
US16/496,609 US20200371338A1 (en) 2017-04-07 2018-04-05 Microscope assembly for capturing and displaying three-dimensional images of a sample
CN201880019344.3A CN110431465B (zh) 2017-04-07 2018-04-05 用于拍摄和呈现样品的三维图像的显微镜装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017107489.9A DE102017107489B3 (de) 2017-04-07 2017-04-07 Mikroskopanordnung zur Aufnahme und Darstellung dreidimensionaler Bilder einer Probe
DE102017107489.9 2017-04-07

Publications (2)

Publication Number Publication Date
WO2018185201A2 WO2018185201A2 (de) 2018-10-11
WO2018185201A3 true WO2018185201A3 (de) 2018-12-27

Family

ID=62027942

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2018/058678 WO2018185201A2 (de) 2017-04-07 2018-04-05 Mikroskopanordnung zur aufnahme und darstellung dreidimensionaler bilder einer probe

Country Status (5)

Country Link
US (1) US20200371338A1 (de)
JP (1) JP6921973B2 (de)
CN (1) CN110431465B (de)
DE (1) DE102017107489B3 (de)
WO (1) WO2018185201A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102019119310A1 (de) * 2019-07-17 2021-01-21 Carl Zeiss Microscopy Gmbh Mikroskop und Verfahren zum Erzeugen eines mikroskopischen Bildes mit einer erweiterten Schärfentiefe
KR102771899B1 (ko) * 2019-09-03 2025-02-25 삼성전자주식회사 주사 전자 현미경 장치 및 그의 동작 방법
JP2021085757A (ja) * 2019-11-27 2021-06-03 国立大学法人神戸大学 顕微鏡による焦点画像群を用いた形状計測方法及び装置
CN113392267B (zh) * 2020-03-12 2024-01-16 平湖莱顿光学仪器制造有限公司 一种用于生成目标对象的二维显微视频信息的方法与设备
CN113395509B (zh) * 2020-03-12 2023-08-25 平湖莱顿光学仪器制造有限公司 提供及呈现目标对象的三维显微视频信息的方法与设备
EP3926385B1 (de) 2020-06-16 2024-05-15 Carl Zeiss Microscopy GmbH Digitales mikroskop und mikroskopischer satz
WO2022097104A1 (en) * 2020-11-07 2022-05-12 Singh Samrat Digitization module for microscopes to enable sample viewing on a smart device
EP4137866A1 (de) 2021-08-18 2023-02-22 Carl Zeiss Microscopy GmbH Digitales mikroskop und verfahren zur aufnahme und darstellung mikroskopischer bilder
CN118882517B (zh) * 2024-07-05 2025-04-15 西安知象光电科技有限公司 一种基于头戴显示装置的三维扫描系统和方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6934072B1 (en) * 2004-05-27 2005-08-23 Angstrom Inc. Variable focal length lens comprising micromirrors with two degrees of freedom rotation and one degree of freedom translation
US20050203367A1 (en) * 2001-06-13 2005-09-15 Ahmed Syed N Guide system
WO2009091366A1 (en) * 2008-01-17 2009-07-23 Thomson Licensing Display system
US20160313556A1 (en) * 2010-11-08 2016-10-27 Seereal Technologies S.A. Display device, in particular a head-mounted display, based on temporal and spatial multiplexing of hologram tiles
WO2017004555A1 (en) * 2015-07-01 2017-01-05 The Trustees Of Columbia University In The City Of New York System, method and computer-accessbile medium for multi-plane imaging of neural circuits

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5896223A (en) 1997-06-13 1999-04-20 Tigliev; George S. Optical system having an unlimited depth of focus
JP2003057169A (ja) * 2001-08-13 2003-02-26 Shiseido Co Ltd 皮膚の三次元画像生成装置
US20040257360A1 (en) * 2001-10-22 2004-12-23 Frank Sieckmann Method and device for producing light-microscopy, three-dimensional images
JP3867143B2 (ja) * 2003-06-25 2007-01-10 独立行政法人産業技術総合研究所 三次元顕微鏡システムおよび画像表示方法
BRPI0607082A2 (pt) * 2005-01-26 2009-08-04 Vizoo Invest Aps dispositivo de exibição e método para reproduzir imagens paradas ou móveis de uma localização
DE102005032354B4 (de) 2005-07-08 2008-04-10 Olympus Soft Imaging Solutions Gmbh Verfahren und Vorrichtung zur Bildaufnahme mit erweitertem Tiefenschärfebereich
DE102006025149A1 (de) 2006-05-30 2007-12-06 Leica Microsystems (Schweiz) Ag Optisches Gerät mit erhöhter Tiefenschärfe
DE102007021981B4 (de) * 2007-05-10 2009-10-08 Leica Microsystems (Schweiz) Ag Optisches Gerät mit Vibrationskompensation
DE102008037074A1 (de) 2008-08-08 2010-02-11 Carl Zeiss Microimaging Gmbh Verfahren und Einrichtung zur Steuerung von Aperturblenden
SG182880A1 (en) 2011-02-01 2012-08-30 Univ Singapore A method and system for interaction with micro-objects
US9874437B2 (en) 2011-12-28 2018-01-23 Femtonics Kft. Method for the 3-dimensional measurement of a sample with a measuring system comprising a laser scanning microscope and such measuring system
US10231704B2 (en) 2013-12-20 2019-03-19 Raghu Raghavan Method for acquiring ultrasonic data
GB201420352D0 (en) 2014-11-17 2014-12-31 Vision Eng Stereoscopic viewing apparatus
FR3034858B1 (fr) * 2015-04-10 2017-05-26 Lltech Man Procede et systeme d'imagerie par microscopie interferentielle plein champ
DE102015118154A1 (de) 2015-10-23 2017-04-27 Arnold & Richter Cine Technik Gmbh & Co. Betriebs Kg Elektronisches Mikroskop, insbesondere Operationsmikroskop
DE102016108664A1 (de) 2016-05-11 2017-07-06 Carl Zeiss Meditec Ag Digitales Stereo-Operationsmikroskop für mehrere Benutzer und Verfahren zur Darstellung mindestens zweier Ansichten eines Objektes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050203367A1 (en) * 2001-06-13 2005-09-15 Ahmed Syed N Guide system
US6934072B1 (en) * 2004-05-27 2005-08-23 Angstrom Inc. Variable focal length lens comprising micromirrors with two degrees of freedom rotation and one degree of freedom translation
WO2009091366A1 (en) * 2008-01-17 2009-07-23 Thomson Licensing Display system
US20160313556A1 (en) * 2010-11-08 2016-10-27 Seereal Technologies S.A. Display device, in particular a head-mounted display, based on temporal and spatial multiplexing of hologram tiles
WO2017004555A1 (en) * 2015-07-01 2017-01-05 The Trustees Of Columbia University In The City Of New York System, method and computer-accessbile medium for multi-plane imaging of neural circuits

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BENJAMIN F GREWE ET AL: "Fast two-layer two-photon imaging of neuronal cell populations using an electrically tunable lens", BIOMED OPT EXPRESS, vol. 2, no. 7, 1 July 2011 (2011-07-01), pages 2035 - 3046, XP055308709, DOI: 10.1364/BOE.2.002035 *
LOUISE HUGHES: "3D printing in microscopy and science outreach", INFOCUS MAGAZINE, 6 December 2015 (2015-12-06), pages 18 - 28, XP055519473, ISSN: 1750-4740, DOI: 10.22443/rms.inf.1.128 *
MATTHEW B BOUCHARD ET AL: "Swept confocally-aligned planar excitation (SCAPE) microscopy for high speed volumetric imaging of behaving organisms - Suppl. Information 1", NATURE PHOTONICS, 1 February 2015 (2015-02-01), England, pages 113 - 119, XP055491984, Retrieved from the Internet <URL:https://media.nature.com/original/nature-assets/nphoton/journal/v9/n2/extref/nphoton.2014.323-s1.pdf> [retrieved on 20180712], DOI: 10.1038/nphoton.2014.323 *
MATTHEW B. BOUCHARD ET AL: "Swept confocally-aligned planar excitation (SCAPE) microscopy for high-speed volumetric imaging of behaving organisms", NATURE PHOTONICS, vol. 9, no. 2, 19 January 2015 (2015-01-19), UK, pages 113 - 119, XP055449894, ISSN: 1749-4885, DOI: 10.1038/nphoton.2014.323 *

Also Published As

Publication number Publication date
CN110431465B (zh) 2021-12-21
WO2018185201A2 (de) 2018-10-11
DE102017107489B3 (de) 2018-07-05
JP2020508496A (ja) 2020-03-19
US20200371338A1 (en) 2020-11-26
CN110431465A (zh) 2019-11-08
JP6921973B2 (ja) 2021-08-18

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