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WO2018172066A1 - Procédé et dispositif de détermination d'un traitement non thérapeutique des dents - Google Patents

Procédé et dispositif de détermination d'un traitement non thérapeutique des dents Download PDF

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Publication number
WO2018172066A1
WO2018172066A1 PCT/EP2018/055493 EP2018055493W WO2018172066A1 WO 2018172066 A1 WO2018172066 A1 WO 2018172066A1 EP 2018055493 W EP2018055493 W EP 2018055493W WO 2018172066 A1 WO2018172066 A1 WO 2018172066A1
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic treatment
teeth
saliva
flashes
calcium
Prior art date
Application number
PCT/EP2018/055493
Other languages
German (de)
English (en)
Inventor
Andreas Bock
Thomas Welss
Kristin Miehlich
Claudia Hundeiker
Original Assignee
Henkel Ag & Co. Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel Ag & Co. Kgaa filed Critical Henkel Ag & Co. Kgaa
Publication of WO2018172066A1 publication Critical patent/WO2018172066A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4538—Evaluating a particular part of the muscoloskeletal system or a particular medical condition
    • A61B5/4542—Evaluating the mouth, e.g. the jaw
    • A61B5/4547—Evaluating teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/742—Details of notification to user or communication with user or patient; User input means using visual displays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4261—Evaluating exocrine secretion production
    • A61B5/4277—Evaluating exocrine secretion production saliva secretion

Definitions

  • the invention relates to methods and arrangements for determining non-therapeutic treatment of teeth.
  • a method for determining a non-therapeutic treatment of teeth, the method comprising delivering a photoprotein that reacts with free calcium ions to the saliva surrounding the teeth, measuring light flashes produced by the photoprotein upon reaction with calcium ions Determining a calcium content of the saliva based on the measured light flashes and determining a non-therapeutic treatment of the teeth based on the determined calcium content.
  • an arrangement for determining a non-therapeutic treatment of teeth according to the method described above is provided.
  • a method of monitoring the success of a non-therapeutic treatment of teeth which comprises repeatedly performing, during non-therapeutic treatment of teeth, a photoprotein that reacts with free calcium ions to which the teeth surrounding a user's saliva, measuring light flashes produced by the photoprotein upon reaction with calcium ions, and determining a calcium content of the saliva based on the measured flashes of light and determining the success of the non-therapeutic treatment based on the determined calcium levels.
  • FIG. 1 shows an example of a slight tooth erosion, an advanced tooth erosion and a severe tooth erosion.
  • Figure 2 shows an arrangement for determining a non-therapeutic treatment of teeth.
  • Figure 3 is a graph of the calcium content of a user's saliva over time.
  • FIG. 4 is a flowchart illustrating a method of determining non-therapeutic treatment of teeth.
  • Figure 5 shows an arrangement for determining a non-therapeutic treatment of teeth.
  • Figure 6 is a flow chart illustrating a method of monitoring the success of non-therapeutic treatment of teeth.
  • Demineralization is an underlying process in the development of dental caries, tooth erosion and tooth hypersensitivity.
  • the demineralization of the hard tooth substance causes a loss of dental integrity.
  • Minerals are generally contained in the hard tooth substance in a mineralized state
  • Dental erosion is the progressive, gradual loss of hard tooth substance from the tooth surface and is often caused by acid-containing drinks and food. Tooth erosion causes tooth demineralization and can lead to exposure of the dentin. Dental erosion can also be accelerated by brushing acid softened enamel (or dentin), which can result in complete removal of enamel and dentin. In particular, tooth erosion refers to non-bacterial processes that cause the progressive loss of hard hard tooth substance. Tooth erosion occurs when the enamel is removed by acid. Normally, the calcium contained in the saliva, remineralizing (or enhancing) the teeth after ingestion of acid, but the presence of too much acid or too little calcium in the mouth (ie in the saliva) prevents remineralization.
  • FIG. 1 shows an example of a slight tooth erosion 101, an advanced tooth erosion 102 and a heavy tooth erosion 103.
  • Dental erosion can be detected by visual inspection. Signs and symptoms that show erosion include the increased transparency of incisors, the increase in fillings over surrounding teeth, and wear on surface that is not chewed. However, it may take some time for these symptoms to develop to a visible degree.
  • the calcium content in saliva is determined according to various embodiments. As explained above, a sufficient content of calcium in saliva is essential for extensive remineralization of the enamel. A low content can lead to a continuous loss of tooth hard tissue, the teeth become more sensitive and lose the natural teeth whitening.
  • the salivary calcium content can be determined using photoproteins that specifically bind calcium and thereby emit blue light.
  • the amount of light pulses is directly proportional to the free calcium. Based on the determined calcium content, a non-therapeutic treatment can be determined and suggested to a user.
  • Figure 2 shows an arrangement for determining a non-therapeutic treatment of teeth.
  • the saliva in a user's mouth 201 is supplied with a photoprotein 206 which reacts with free calcium ions and which emits light flashes 202 upon reaction (e.g., binding) of calcium ions (by luminescence).
  • the flashes of light 202 are typically very short and faint and are invisible to the naked eye.
  • the user may take the substance himself or she may be supplied to him by a third person, for example a doctor.
  • the photoprotein can be supplied, for example, in a pharmaceutically acceptable dosage form, for example in the form of a liquid, powder or gel.
  • the substance may have as protein (or protein complex), for example, aequorin, obelin, clytin, mitrocomin, halistaurin, phialidin, mnemiopsin, symplectin, gr-bolinopsin, casein, calsequestrin, calexcitin, calcium-binding cysteine protease and / or calmodulin.
  • the photoprotein reacts with the free calcium ions in the saliva and emits light flashes (ie, light pulses) measured by a measuring device 203. For example, their number (eg, over time) or their density is measured (ie, observed).
  • the measurement can be carried out in the saliva as well as on the teeth.
  • the measurement is made in saliva.
  • the measurement can be carried out, for example, with a light sensor which is tuned to the wavelength of the light flashes.
  • the flashes of light can be considered as an optical signal representing the calcium content in the saliva when the photoprotein (or photoprotein complex) binds calcium.
  • the measuring device 203 may include, for example, detecting and / or measuring the flashes of light, a spectrophotometer, a charge coupled device (CCD), a digital camera, an intraoral camera, a video scope, a photographic film, a fiber optic device, a photometric detector, a photomultiplier Avalanche photodiode, a photosensitive array and / or a micro-electro-mechanical system (MEMS) have.
  • the analyzer 204 is coupled to the measuring device 203.
  • the analyzer 204 may be, for example, an electronic device, e.g. be a portable electronic device such as a smart phone, a smartband, a smartwatch, a PDA (Personal Digital Assistant) or a tablet computer (or integrated into or realized by it) but also any computer or a smart mirror.
  • the measuring device 203 may have any size. To allow the user to carry the measuring device 203 with him (and to use it, for example, with his smartphone), it may for example have a size that fits easily into hand and trouser pockets (eg footprint ⁇ 36 cm ⁇ height ⁇ 2 cm).
  • the analyzer 204 calculates the measured flashes of light and generates a value or verbal guidance to the user based on the measured flashes of light. For example, analyzer 204 may determine from the amount of flashes of light over time a determined calcium value (with some unit, e.g., mmol / 1 or mg / dl). The analyzer 204 may normalize the amount of flashes of light, e.g.
  • the measuring device 203 with respect to the amount of time the light flashes are detected (and counted) by the measuring device 203 with respect to the amount of photoprotein 206 delivered, the observed tooth surface, and / or the size of the user's mouth (eg, whether it is a man's mouth, woman's mouth or child's mouth or even based on more accurate dimensions).
  • the analyzer 204 can be calibrated by measuring the flashes of light emitted when a predetermined amount of photoprotein is in a liquid given calcium concentration is given. This can be carried out, for example, for different calcium concentrations, so that conversely, based on a measurement, a calcium concentration can be deduced.
  • the analyzer 204 may then determine a non-therapeutic treatment proposal based on the measured flashes of light, based on the determined calcium value, for example, and display it on a display 205 coupled to the analyzer 204 (eg, optionally, the display of the smartphone or tablet computer).
  • the analyzer may execute analysis software (e.g., an app) that performs the functions described above and below.
  • the display 205 is, for example, a screen, a display, a touch screen in order to provide the user with information, for example with recommendations for non-therapeutic treatment that have been determined.
  • the analyzer 204 may also have an audio output for this purpose.
  • analyzer 204 may derive and display product recommendations for individual oral hygiene.
  • Typical salivary calcium levels are 1.2 to 2.8 mmol / L or 4.8 to 11.2 mg / dL.
  • the analyzer 204 may recommend calcium-containing toothpastes to the user, suggesting that they take more calcium-containing foods (and make appropriate suggestions), brush the teeth more frequently, or use mouthwashes (with suggestions if necessary). which mouthwash the user could use) etc. If the calcium content is sufficient, the analyzer 204 may also indicate that everything is in order. The treatment proposal in this case can be seen as keeping the current habits.
  • the product recommendation may depend on how much the calculated calcium content differs from the normal calcium content.
  • analyzer 204 recommends that the user eat calcium-containing foods when the determined calcium level is less than 1.2 mmol / L and recommends a calcium-containing toothpaste to the user if the determined calcium level is below 1 mmol / L.
  • the analyzer 204 recommends, for example, a visit to the dentist.
  • the non-therapeutic treatment may be determined in addition to the measurement information taken by the measurement device 203 (eg, the number, frequency, or density of light flashes) based on predetermined data.
  • the predetermined data can be stored, for example, in a memory and / or provided by an external data processing system.
  • the given data can be in the form of a database.
  • the given data may contain literature data, for example regarding the compatibility and ingredients of oral hygiene products, or also data regarding treatment courses of other consumers. Accordingly, the data may include information about oral hygiene products, eg their ingredients and effects on body parts.
  • the given data can be obtained, for example, at the request of the user or regularly from an external data processing system.
  • the analyzer 204 may include a communications interface for communicating with a server 207 (or, generally, an external data processing facility).
  • the server 207 may be contactable over the Internet, and may be part of a server network that implements a cloud, for example.
  • the measuring device 203 and the analyzing device 204 are likewise connected by means of a communication interface.
  • the communication interfaces can be set up, for example, for wired or wireless communication.
  • data energy can be transmitted via USB (Universal Serial Bus), WLAN (Wireless Local Area Network), NFC (Near Field Communication), Thread, ZigBee and / or Bluetooth.
  • the two communication interfaces may have corresponding communication circuits and / or be coupled to these.
  • the analyzer 204 may include a processor coupled to the communication interface (s) so that data transfer may occur between the processor and the meter 203 or the server 207.
  • the communication interfaces can also be completely or partially integrated in the processor.
  • the processor can be for example a microprocessor, a microcontroller or an ASIC (Application Specific Integrated Circuit).
  • the processor can be set up, for example, by means of software for the above and below (also combined) embodiments.
  • the software may be a mobile application, a web application or a desktop application.
  • the software may be stored in a memory of the analysis device 204 and / or at least partially in an external data processing system, such as the server 207, and may be accessible to the processor.
  • the analysis device 204 controls and controls, for example, the measuring device 203 for carrying out the measurement.
  • the analyzing device 204 can compare the measuring information with information stored in a memory, for example a database, or with information obtained from the server 207.
  • the measurement information can be assigned one or more categories, for example based on predetermined value ranges.
  • the analyzer 204 may be implemented, for example, by a user's portable electronic device.
  • the analyzer 204 may be implemented by a server (eg, the server 207 of FIG. 2).
  • the measuring device 203 for example, integrated into a smartphone or in the form of an accessory can be plugged onto a smartphone or tablet
  • send measured values directly into a cloud ie to a server
  • the results of this determination are then sent to the measuring device 203 (e.g., the smartphone or tablet) by a server and displayed there or output as an audible message.
  • the analyzer 204 may optionally include an input device. Data can be input and queried via the input device, which can be used to determine a non-therapeutic treatment. For example, a user may indicate an allergy, preferably specific allergens, and thus, in determining a non-therapeutic treatment, the suggestion of an allergen may be prevented.
  • the analyzer 204 may prompt the user for input of data via a corresponding display.
  • Determining the calcium content can be done for a user over a longer period of time.
  • the analyzer 204 may then record a status of the content of calcium in the saliva of the user for an extended period of time.
  • the analyzer 204 may then, for example, standardize and objectively assess the success of non-therapeutic treatment that the user performs during the time period (and was suggested to him, for example, at the beginning of the time period by the analyzer 204), eg, at home if the user is Smartphone or its tablet computer used. This allows the user to control the individual effectiveness of an oral hygiene product and may (depending on his or her success) increase his or her motivation to carry out appropriate treatment in the longer term.
  • the analyzer 204 allows control and tracking of the mineralization potential of a user's saliva by presenting the measurement results over time.
  • the analyzer 204 may graphically display the measurement results, as shown in FIG.
  • FIG. 3 shows a graph 300 of the calcium content of a user's saliva over time.
  • the analyzer 204 determines the calcium content of a user's saliva every day over a period of several weeks.
  • the days are plotted along the x-axis 301 and the calcium content is given (in a unit, e.g., mmol / l) according to the y-axis scale 302.
  • the values are connected in this example to a smoothed curve 303 to indicate continuous development.
  • the analyzer 204 may also determine the calcium content at shorter time intervals and generate the curve 303 based on a higher (or denser) determined value of the calcium content.
  • the calcium content is given as a percentage, for example, whereby 100% corresponds to the content which, based on empirical values, is normally sufficient for remineralizing the teeth (for example, a value between 1.5 mmol / l and 2.5 mmol / l).
  • the content which corresponds to 100% may also be adapted to the user, for example, for a user who frequently consumes acidic foods, the calcium content corresponding to 100% may be correspondingly increased.
  • the analyzer 204 may again provide care and product recommendations. For example, if the treatment fails to improve, the analyzer 204 may recommend other or more metered products (for example, higher calcium content).
  • the analyzer 204 in determining non-therapeutic treatment (for example, care and product tips), may also include the user's answers to questions regarding his or her general oral hygiene condition, eating habits, general health condition (eg, illnesses, allergies, medication use), and other behaviors (for example smoking habits or sports habits). For example, the analyzer 204 may display corresponding questions on the display 205 and receive and process the responses via an input device (eg, a keyboard or a touch screen), ie, determine the non-therapeutic treatment based on the responses. The analyzer 204 may also base literature data as well as the treatment success of non-therapeutic treatments of other users (for example, using the same software or app) in determining the non-therapeutic treatment.
  • non-therapeutic treatment for example, care and product tips
  • the analyzer 204 may also include the user's answers to questions regarding his or her general oral hygiene condition, eating habits, general health condition (eg, illnesses, allergies, medication use), and other behaviors (for example smoking habits or sports habits).
  • the analyzer 204 may display corresponding
  • the calcium levels detected during non-therapeutic treatment are uploaded to server 207 (e.g., a cloud), e.g. along with a profile of the user, and the analyzer 204 may download such data from other users, for example, users having a profile similar to the user of the analyzer 204 to determine which treatment methods will be successful for users of such or similar profile , It can also be determined server-side which treatments for which user profiles are successful and the analyzer 204 can download this information and include it in the determination of the non-therapeutic treatment.
  • server 207 e.g., a cloud
  • the analyzer 204 may download such data from other users, for example, users having a profile similar to the user of the analyzer 204 to determine which treatment methods will be successful for users of such or similar profile . It can also be determined server-side which treatments for which user profiles are successful and the analyzer 204 can download this information and include it in the determination of the non-therapeutic treatment.
  • the user profile may include oral hygiene habits, eating habits, drinking habits, sports habits, smoking habits, gender, height, age, weight, etc.
  • FIG. 4 a method as shown in FIG. 4 is provided.
  • FIG. 4 shows a flowchart 400 illustrating a method for determining non-therapeutic treatment of teeth.
  • a photoprotein that reacts with free calcium ions is delivered to the saliva surrounding the teeth.
  • a calcium content of the saliva is determined based on the measured flashes of light.
  • a non-therapeutic treatment of the teeth is determined based on the determined calcium content.
  • the calcium content of a user's saliva is measured by measuring how much saliva is concentrated on a photoprotein, which reacts with calcium, responds and determines a treatment proposal based on the calcium content.
  • the method allows a user to receive individual care recommendations and product recommendations that address their needs.
  • the user can be offered a recommended oral hygiene product directly for sale and the user can initiate the purchase by entering the purchase.
  • the user can also be offered further information on the purchase.
  • This further information may refer to more detailed treatment and application instructions.
  • a software / app receives the request that the user wants to purchase the oral hygiene product, stores the request, and / or submits the request to a trading company that distributes the oral hygiene products.
  • the user may be prompted by the software / app to enter his personal data (address, bank information, delivery preference, etc.) via the input unit.
  • the user can be indicated where (for example, drugstore, pharmacy, etc.) he can purchase the oral hygiene product.
  • the software / app may be the same software or app that performs the method of determining non-therapeutic treatment of teeth.
  • the user can be introduced to the use of oral hygiene products which are produced individually for the user, and an order process can be initiated, preferably by calling up a website of a manufacturer of individual cosmetic products.
  • a product that is individually tailored to their needs.
  • This can be a product manufactured specifically for the user or a so-called “mass-customized” product, but in the case of a "mass-customized” product, an individualization can be achieved by varying a few characteristics of a product, which are decisive from the customer's point of view.
  • these "mass customized” products are based on the concept of modularization, that is, the product can be assembled individually from various modules / building blocks.
  • the selection of chemically and / or physically incompatible ingredients or the selection of the determined calcium content of unsuitable ingredients can be avoided.
  • the selection for the determined calcium content of suitable ingredients can be specified or suggested by the product configurator.
  • the care recommendation may include the recommendation of a dental visit.
  • the recommendation of a dental visit may directly link the analyzer 204 to software (e.g., an app) that allows an appointment with a dentist.
  • an appointment booking process may be initiated directly via the analyzer 204.
  • the contact data of dentists can be stored in the analysis device 204 and these can be displayed to the user.
  • the selection can be restricted via filters, such as the postal code. It is also possible that the contact details of the dentist, where the user goes regularly, are preset and no selection of a dentist must be made.
  • Figure 5 shows an assembly 500 for determining non-therapeutic treatment of teeth.
  • the assembly 500 includes a measuring device 501 configured to measure flashes of light produced by a photoprotein supplied to the saliva surrounding the teeth in response to free calcium ions.
  • the assembly 500 includes an analyzer 502 configured to determine a calcium content of the saliva based on the measured flashes of light and determine a non-therapeutic treatment of the teeth based on the determined calcium content.
  • FIG. Figure 6 is a flow chart 600 illustrating a method for monitoring the success of non-therapeutic treatment of teeth.
  • the success of the non-therapeutic treatment is determined based on the calculated calcium levels.
  • the determination of the calcium content of Figure 4 during a treatment period is continuous, i. e.g. repeated or regular, carried out and based on the calculated calcium content values, the success of the treatment is assessed.
  • the method according to FIG. 6 makes it possible to monitor and track the efficacy of a non-therapeutic treatment in an objective and standardized manner in order to assess the mineralization potential of the teeth or saliva.
  • the effectiveness of the treatment can be optimized by targeted provision of calcium.
  • An overview of the success of a non-therapeutic treatment may increase the user's motivation to carry out the non-therapeutic treatment in the longer term - also by comparison with other users. For example, results from multiple users are loaded onto a server so that each user can compare the success of the treatment with him to the success of the treatment with other users.
  • Embodiment 1 is a method for determining a non-therapeutic treatment of teeth, as shown in FIG.
  • Embodiment 2 is the method according to Embodiment 1, further comprising displaying an indication of the determined non-therapeutic treatment on a display.
  • Embodiment 3 is the method according to Embodiment 1 or 2, wherein the non-therapeutic treatment involves the use of an oral hygiene product.
  • Embodiment 4 is the method of any one of Embodiments 1 to 3, wherein determining the non-therapeutic treatment comprises determining a chemical composition of an oral hygiene product.
  • Embodiment 5 is the method according to any one of Embodiments 1 to 4, wherein measuring light pulses produced by the photoprotein upon reaction with calcium ions comprises counting light flashes detected by a detector.
  • Embodiment 6 is the method according to any one of Embodiments 1 to 5, wherein determining the calcium content of the saliva based on the measured light flashes is based on a number of detected flashes of light per unit time.
  • Embodiment 7 is the method according to any one of Embodiments 1 to 6, wherein the non-therapeutic treatment is determined based on personal information about the user for which the calcium content in the saliva is detected.
  • Embodiment 8 is the method of Embodiment 7, wherein the personal information includes one or more of information about the age, sex, height, weight, allergies / allergens, and habits of the user.
  • Embodiment 9 is the method according to Embodiment 7, wherein the personal information includes one or more information about eating habits, drinking habits, sports habits, smoking habits, oral hygiene habits, and oral hygiene products used.
  • Embodiment 10 is the method of any one of Embodiments 1 through 9, wherein the non-therapeutic treatment is determined based on the success of one or more non-therapeutic treatments with one or more other users.
  • FIG. 1 is the method of Embodiment 10, including selecting one or more other users from a plurality of candidates based on a comparison of personal information about the user with personal information about the candidates.
  • Embodiment 12 is the method according to one of the embodiments 1 to 1 1, comprising storing the determined calcium content.
  • Embodiment 13 is the method according to one of the embodiments 1 to 12, comprising storing the determined calcium content on a server.
  • Embodiment 14 is an arrangement for determining a non-therapeutic treatment of teeth, as shown in FIG.
  • Embodiment 15 is the arrangement according to embodiment 14, further comprising a display, wherein the analysis device is set up to display an indication of the determined non-therapeutic treatment on the display.
  • Embodiment 16 is the arrangement according to embodiment 14 or 15, wherein the non-therapeutic treatment comprises the use of an oral hygiene product.
  • Embodiment 17 is the assembly of any one of Embodiments 14-16, wherein determining the non-therapeutic treatment comprises determining a chemical composition of an oral hygiene product.
  • Embodiment 18 is the arrangement of one of embodiments 14 to 17, comprising a detector, wherein measuring light flashes produced by the photoprotein upon reaction with calcium ions comprises counting light flashes detected by a detector.
  • Embodiment 19 is the arrangement of one of embodiments 14 to 18, wherein determining the calcium content of the saliva based on the measured light flashes is based on a number of detected flashes of light per unit time.
  • Embodiment 20 is the arrangement according to any one of Embodiments 14 to 19, wherein the analysis device is arranged to determine the non-therapeutic treatment based on personal information about the user for which the calcium content in the saliva is detected.
  • Embodiment 21 is the arrangement of Embodiment 20, wherein the personal information includes one or more of information about the age, sex, height, weight, allergies / allergens, and habits of the user.
  • Embodiment 22 is the arrangement according to Embodiment 21, wherein the personal information includes one or more information about eating habits, drinking habits, sports habits, smoking habits, oral hygiene habits, and oral hygiene products used.
  • Embodiment 23 is the arrangement of one of embodiments 14 to 22, wherein the analysis device is configured to determine the non-therapeutic treatment based on the success of one or more non-therapeutic treatments on one or more other users.
  • Embodiment 24 is the arrangement of embodiment 23, wherein the analysis device is configured to select the one or more other users from a plurality of candidates based on a comparison of personal information about the user with personal information about the candidates.
  • Embodiment 25 is the arrangement according to one of the embodiments 14 to 24, comprising a memory which is adapted to store the determined calcium content.
  • Embodiment 26 is the arrangement according to one of the embodiments 14 to 25, comprising a server which is adapted to store the determined calcium content.
  • Embodiment 27 is a method for monitoring the success of a non-therapeutic treatment of teeth, as shown in FIG.
  • Embodiment 28 is the method of embodiment 26, further comprising displaying an indication of the determined success on a display.
  • Embodiment 29 is the method of embodiment 27 or 28, further comprising displaying an indication of non-therapeutic treatment on a display.
  • Embodiment 30 is the method of any one of Embodiments 27 to 29, wherein the non-therapeutic treatment involves the use of an oral hygiene product.
  • Embodiment 31 is the method according to any one of Embodiments 27 to 30, wherein the non-therapeutic treatment comprises the use of an oral hygiene product having a certain chemical composition.
  • Embodiment 32 is the method according to any one of Embodiments 27 to 31, wherein measuring light flashes produced by the photoprotein upon reaction with calcium ions comprises counting light flashes detected by a detector.
  • Embodiment 33 is the method according to any one of Embodiments 27 to 32, wherein determining the calcium content of the saliva based on the measured light flashes is based on a number of detected flashes of light per unit time.
  • Embodiment 34 is the method according to any one of Embodiments 27 to 33, wherein the non-therapeutic treatment is determined based on personal information about the user for which the calcium content in the saliva is detected.
  • Embodiment 35 is the method of Embodiment 34, wherein the personal information includes one or more of information about the age, sex, height, weight, allergies / allergens, and habits of the user.
  • Embodiment 36 is the method of Embodiment 34, wherein the personal information includes one or more information about eating habits, drinking habits, sports habits, smoking habits, oral hygiene habits, and oral hygiene products used.
  • Embodiment 37 is the method of any one of Embodiments 27 through 36, wherein the non-therapeutic treatment is determined based on the success of one or more non-therapeutic treatments with one or more other users.
  • Embodiment 38 is the method of embodiment 37, comprising selecting one or more other users from a plurality of candidates based on a comparison of personal information about the user with personal information about the candidates.
  • Embodiment 39 is the method according to one of the embodiments 27 to 38, comprising storing the determined calcium content.
  • Embodiment 40 is the method according to one of embodiments 27 to 39, comprising storing the determined calcium content on a server.
  • a device for evaluating a measurement of the calcium content of saliva which is adapted to receive from a measuring device measurement information about flashes of light emitted by the saliva in response to a photoprotein, to compare the measurement information with predetermined threshold values and based on the comparison to determine a non-therapeutic treatment.
  • a circuit is to be understood as any entity that implements logic, and may be hardware, software, firmware, or any combination thereof.
  • a "circuit” may be a hard-wired logic circuit or a programmable logic circuit, such as a programmable processor, such as a microprocessor.
  • a “circuit” can also be understood to mean a processor that executes software, to understand, for example, any type of computer program, such as a computer program in programming code for a virtual machine, such as a Java computer. computer program.
  • a “circuit” may be understood as any type of implementation of the functions described below.

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Abstract

Selon différents modes de réalisation donnés à titre d'exemple, l'invention concerne un procédé de détermination d'un traitement non thérapeutique des dents, le procédé consistant à appliquer une photoprotéine, qui réagit avec des ions calcium libres, à la salive entourant les dents, à mesurer des éclairs de lumière produits par la photoprotéine lors de la réaction avec des ions calcium, à déterminer une teneur en calcium de la salive sur la base des éclairs de lumière mesurés et à déterminer un traitement non thérapeutique des dents sur la base de la teneur en calcium déterminée.
PCT/EP2018/055493 2017-03-24 2018-03-06 Procédé et dispositif de détermination d'un traitement non thérapeutique des dents WO2018172066A1 (fr)

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DE102017205012.8A DE102017205012A1 (de) 2017-03-24 2017-03-24 Verfahren und Anordnung zum Ermitteln einer nicht-therapeutischen Behandlung von Zähnen
DE102017205012.8 2017-03-24

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2682132A1 (fr) * 2006-12-21 2014-01-08 Calcivis Limited Composition et procédé permettant de déceler la déminéralisation

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US20080038686A1 (en) 2006-04-18 2008-02-14 Shigemi Nagai Methods and kits for early stage caries detection
GB0909206D0 (en) 2009-05-28 2009-07-15 Lux Innovate Ltd Approximal imaging device
GB201011913D0 (en) 2010-07-15 2010-09-01 Lux Innovate Ltd Detecting device
WO2015094340A1 (fr) 2013-12-20 2015-06-25 Colgate-Palmolive Company Indice d'identification de plaque amélioré

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2682132A1 (fr) * 2006-12-21 2014-01-08 Calcivis Limited Composition et procédé permettant de déceler la déminéralisation

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