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WO2018164580A8 - Biomarkers for cellular senescence - Google Patents

Biomarkers for cellular senescence Download PDF

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Publication number
WO2018164580A8
WO2018164580A8 PCT/NL2018/050148 NL2018050148W WO2018164580A8 WO 2018164580 A8 WO2018164580 A8 WO 2018164580A8 NL 2018050148 W NL2018050148 W NL 2018050148W WO 2018164580 A8 WO2018164580 A8 WO 2018164580A8
Authority
WO
WIPO (PCT)
Prior art keywords
biomarkers
senescent
cellular senescence
cell
biomarker
Prior art date
Application number
PCT/NL2018/050148
Other languages
French (fr)
Other versions
WO2018164580A1 (en
Inventor
Marco DEMARIA
Alejandra HERNANDEZ-SEGURA
Original Assignee
Rijksuniversiteit Groningen
Academisch Ziekenhuis Groningen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rijksuniversiteit Groningen, Academisch Ziekenhuis Groningen filed Critical Rijksuniversiteit Groningen
Priority to CN201880030418.3A priority Critical patent/CN110678751A/en
Priority to EP18710575.4A priority patent/EP3593134A1/en
Priority to JP2019571199A priority patent/JP2020511674A/en
Priority to US16/492,410 priority patent/US20200041492A1/en
Publication of WO2018164580A1 publication Critical patent/WO2018164580A1/en
Publication of WO2018164580A8 publication Critical patent/WO2018164580A8/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to biomarkers and uses thereof, in particular to a set of proteins or mRNAs that provides a significant indication as to whether a cell is senescent or not. Provided is the use of a biomarker panel comprising six or more polypeptides, or their encoding mRNA's, wherein the panel comprises at least the biomarkers TSPAN13, GDNF, C2CD5, SUSD6, BCL2L2, PLK3, or a variant or fragment thereof, as a biomarker set for cellular senescence. Also provided is a senescent cell detection kit for detecting senescent cells, and a drug conjugate for killing a senescent cell.
PCT/NL2018/050148 2017-03-09 2018-03-09 Biomarkers for cellular senescence WO2018164580A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201880030418.3A CN110678751A (en) 2017-03-09 2018-03-09 Biomarkers for cellular senescence
EP18710575.4A EP3593134A1 (en) 2017-03-09 2018-03-09 Biomarkers for cellular senescence
JP2019571199A JP2020511674A (en) 2017-03-09 2018-03-09 Cell aging biomarker
US16/492,410 US20200041492A1 (en) 2017-03-09 2018-03-09 Biomarkers for cellular senescence

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17160165 2017-03-09
EP17160165.1 2017-03-09

Publications (2)

Publication Number Publication Date
WO2018164580A1 WO2018164580A1 (en) 2018-09-13
WO2018164580A8 true WO2018164580A8 (en) 2018-11-08

Family

ID=58266455

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL2018/050148 WO2018164580A1 (en) 2017-03-09 2018-03-09 Biomarkers for cellular senescence

Country Status (5)

Country Link
US (1) US20200041492A1 (en)
EP (1) EP3593134A1 (en)
JP (1) JP2020511674A (en)
CN (1) CN110678751A (en)
WO (1) WO2018164580A1 (en)

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* Cited by examiner, † Cited by third party
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CN111257565A (en) * 2018-12-03 2020-06-09 上海细胞治疗集团有限公司 Detection kit and detection method for aged cells
CN111366736A (en) * 2020-03-31 2020-07-03 中国科学院昆明动物研究所 Serum protein markers and applications for key pathways of healthy aging
KR20220056730A (en) * 2020-10-28 2022-05-06 의료법인 성광의료재단 Composition for preventing and treating disc disease containing ABT263 as an active ingredient
CN112359103B (en) * 2020-11-10 2023-03-14 中国科学院动物研究所 Molecular marker and regulation target for human skin aging and application thereof
CN112891358B (en) * 2020-11-19 2023-05-12 苏州正永生物医药有限公司 Application of BCL-2 inhibitor and pharmaceutical composition for treating aging-related skin diseases
EP4163379A4 (en) * 2020-12-22 2024-08-14 Institute Of Zoology, Chinese Academy Of Sciences METHODS FOR IDENTIFYING AND/OR REGULATION OF SENESCENCE
CN113652491A (en) * 2021-02-02 2021-11-16 暨南大学 Application of m6A RNA methylation content and its methylation-related enzymes and binding proteins in the preparation of aging detection kits
CN114524872A (en) * 2022-03-09 2022-05-24 广州诺诚生物技术研发有限公司 Monoclonal antibody for breast cancer detection and kit thereof
JPWO2023238845A1 (en) * 2022-06-07 2023-12-14

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Also Published As

Publication number Publication date
CN110678751A (en) 2020-01-10
JP2020511674A (en) 2020-04-16
WO2018164580A1 (en) 2018-09-13
US20200041492A1 (en) 2020-02-06
EP3593134A1 (en) 2020-01-15

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