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WO2018163784A1 - Dispositif de mesure, procédé de mesure, et programme associé - Google Patents

Dispositif de mesure, procédé de mesure, et programme associé Download PDF

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Publication number
WO2018163784A1
WO2018163784A1 PCT/JP2018/005805 JP2018005805W WO2018163784A1 WO 2018163784 A1 WO2018163784 A1 WO 2018163784A1 JP 2018005805 W JP2018005805 W JP 2018005805W WO 2018163784 A1 WO2018163784 A1 WO 2018163784A1
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WO
WIPO (PCT)
Prior art keywords
laser light
value
wavelength
light
measuring
Prior art date
Application number
PCT/JP2018/005805
Other languages
English (en)
Japanese (ja)
Inventor
朝士 平野
智之 東ヶ▲崎▼
剛司 樋口
Original Assignee
京セラ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2017161545A external-priority patent/JP6847789B2/ja
Application filed by 京セラ株式会社 filed Critical 京セラ株式会社
Priority to US16/492,097 priority Critical patent/US11666228B2/en
Priority to EP18764463.8A priority patent/EP3593719A4/fr
Priority to CN201880016217.8A priority patent/CN110381830A/zh
Publication of WO2018163784A1 publication Critical patent/WO2018163784A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0285—Measuring or recording phase velocity of blood waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters

Definitions

  • the present disclosure relates to a measurement apparatus, a measurement method, and a program.
  • a pulse oximeter for measuring arterial blood oxygen saturation is known (see, for example, Patent Document 1).
  • a blood flow measurement apparatus that irradiates a fingertip with a laser beam and measures blood flow based on scattered light from blood flow of capillaries at the fingertip is known (see, for example, Patent Document 2).
  • the measuring apparatus includes a first laser light source, a second laser light source, a light receiving unit, and a control unit.
  • the first laser light source emits laser light having a first wavelength.
  • the second laser light source emits laser light having a second wavelength different from the first wavelength.
  • the light receiving unit receives scattered light of laser light from a region to be examined.
  • the control unit calculates a first value based on an output of the light receiving unit based on reception of scattered light of the laser light of the first wavelength, and the control unit calculates the first value based on reception of scattered light of the laser light of the second wavelength.
  • a second value is calculated based on the output of the light receiving unit, and oxygen saturation is measured based on the ratio of the first value to the second value.
  • the measuring method includes a step of emitting a laser beam having a first wavelength to a test site, a step of emitting a laser beam having a second wavelength different from the first wavelength to the test site, and a step from the test site. Receiving the scattered light of the laser beam.
  • the measuring method includes a step of calculating a first value based on reception of scattered light of the laser light of the first wavelength, and a second value based on reception of scattered light of the laser light of the second wavelength. And calculating oxygen saturation based on a ratio of the first value to the second value.
  • One aspect of the program is a step of emitting a laser beam having a first wavelength to a test site, a step of emitting a laser beam having a second wavelength different from the first wavelength to the test site, Receiving the scattered light of the laser beam from the examination site.
  • the program causes the computer to calculate a first value based on the reception of the scattered light of the laser light of the first wavelength, and to execute a second value based on the reception of the scattered light of the laser light of the second wavelength.
  • FIG. 1 It is a figure which shows an example of a blood pressure meter typically. It is a figure which shows an example of a thermometer typically. It is a figure which shows typically an example of the mounting state of the measuring instrument provided with the measuring apparatus which uses a temple as a test site. It is a fragmentary sectional view of the measuring instrument shown in FIG.
  • FIG. 1 is a functional block diagram showing a schematic configuration of the measuring apparatus 100 according to the first embodiment.
  • the measurement apparatus 100 according to the present embodiment includes a biosensor 110, a control unit 140, a notification unit 150, and a storage unit 160.
  • the measuring apparatus 100 uses the biosensor 110 to acquire a biometric output of a subject (user) that contacts the measuring apparatus 100 and measures biometric information based on the biometric output.
  • the measuring apparatus 100 according to the present embodiment can measure the oxygen saturation and blood flow rate of the subject using the biosensor 110.
  • the measurement apparatus 100 according to the present embodiment uses, for example, percutaneous arterial oxygen saturation (SpO 2 , S: Saturation), P: Percutaneous (transcutaneous) as values indicating the oxygen saturation of the subject. ) Or Pulse Oximetry (O 2 : Oxygen (oxygen)).
  • SpO 2 percutaneous arterial oxygen saturation
  • P Percutaneous (transcutaneous)
  • Pulse Oximetry O 2 : Oxygen (oxygen)
  • the biological information measured by the measuring apparatus 100 is not necessarily limited to SpO 2 and blood flow volume.
  • the measuring apparatus 100 may measure any biological information that can be measured using the biological sensor 110.
  • SaO 2 percutaneous arterial oxygen saturation
  • S Saturation (saturation)
  • a artery (artery)
  • O 2 Oxygen (oxygen)
  • SpO 2 is a method of indirectly measuring SaO 2 , and if the measurement conditions are in place, both take recent values.
  • the biosensor 110 acquires a biometric output from the test portion of the subject that contacts the measuring device 100.
  • the test site is an arbitrary site from which a biometric output can be acquired, and in the present embodiment, the test site will be described below as a finger.
  • the site to be examined may be a finger, an arm, an ear, a forehead, a neck, a back, a foot, and other parts together with a finger, or a part arbitrarily combining these parts.
  • the biosensor 110 includes a light emitting unit and a light receiving unit.
  • the biosensor 110 includes a first laser light source 121 and a second laser light source 122 as light emitting units.
  • the biosensor 110 includes a first light receiving unit 131 and a second light receiving unit 132 as light receiving units.
  • the first laser light source 121 and the second laser light source 122 emit laser light having a wavelength capable of detecting a predetermined component contained in blood as measurement light.
  • the first laser light source 121 and the second laser light source 122 are each configured by, for example, an LD (Laser Diode).
  • a vertical cavity surface emitting laser (VCSEL: vertical cavity surface emitting laser) is used as a laser light source.
  • VCSEL vertical cavity surface emitting laser
  • DFB distributed feedback laser
  • FP Perot type laser
  • the first laser light source 121 and the second laser light source 122 each emit laser beams having different wavelengths.
  • the first laser light source 121 emits laser light having a first wavelength (hereinafter also referred to as “first laser light”).
  • the first wavelength is a wavelength having a large difference between the absorbance of hemoglobin bound to oxygen (hereinafter also referred to as “oxygenated hemoglobin”) and the absorbance of hemoglobin not bound to oxygen (hereinafter also referred to as “reduced hemoglobin”).
  • the first wavelength is, for example, a wavelength from 600 nm to 700 nm, and the first laser light is so-called red light. In the present embodiment, the following description will be made assuming that the first wavelength is 660 nm.
  • the second laser light source 122 emits laser light having a second wavelength (hereinafter also referred to as “second laser light”).
  • the second wavelength is a wavelength different from the first wavelength.
  • the second wavelength is a wavelength in which the difference between the absorbance of oxygenated hemoglobin and the absorbance of reduced hemoglobin is small compared to the first wavelength.
  • the second wavelength is, for example, a wavelength of 800 nm to 1000 nm, and the second laser light is so-called near infrared light. In the present embodiment, the following description will be made assuming that the second wavelength is 850 nm.
  • the first light receiving unit 131 and the second light receiving unit 132 receive the scattered light (detection light) scattered from the test site of the measurement light applied to the test site as the biometric output.
  • the first light receiving unit 131 and the second light receiving unit 132 are each configured by, for example, a PD (photodiode).
  • the biological sensor 110 transmits a photoelectric conversion signal of scattered light received by the first light receiving unit 131 and the second light receiving unit 132 to the control unit 140.
  • FIG. 2 is a schematic diagram for explaining an example of the usage state of the measuring apparatus 100.
  • the measuring apparatus 100 measures biological information in a state where the subject is in contact with a specific position (measurement unit) in the measuring apparatus 100.
  • the measuring apparatus 100 may measure the biological information in a state where the subject does not contact the test site at a specific position (measurement unit) in the measuring apparatus 100.
  • the first light receiving unit 131 receives the scattered light from the test site of the first laser light emitted from the first laser light source 121.
  • the first light receiving unit 131 may be configured by a PD capable of detecting light having a wavelength of scattered light of the first laser light (red light).
  • the second light receiving unit 132 receives the scattered light from the test site of the second laser light emitted from the second laser light source 122.
  • the second light receiving unit 132 may be configured by a PD that can detect light having the wavelength of the scattered light of the second laser light (near infrared light).
  • the first light receiving unit 131 and the second light receiving unit 132 are arranged in the measurement apparatus 100 at positions where the scattered light of the laser light emitted from the first laser light source 121 and the second laser light source 122 can be received, respectively.
  • Reduced hemoglobin easily absorbs the first laser light that is red light, and hardly absorbs the second laser light that is near-infrared light.
  • oxygenated hemoglobin is difficult to absorb both the first laser light that is red light and the second laser light that is near-infrared light. That is, the first laser light that is red light is easily absorbed by reduced hemoglobin and is not easily absorbed by oxygenated hemoglobin.
  • the second laser light which is near-infrared light, is difficult to be absorbed by reduced hemoglobin and oxygenated hemoglobin.
  • the first laser beam is mainly absorbed by reduced hemoglobin and scattered by oxygenated hemoglobin. Therefore, the received light intensity of the scattered light of the first laser light as the biometric output received by the first light receiving unit 131 is due to the amount of oxygenated hemoglobin.
  • the second laser light is scattered by reduced hemoglobin and oxygenated hemoglobin. Therefore, the received light intensity of the scattered light of the second laser light as the biometric output received by the second light receiving unit 132 is due to the total amount of hemoglobin including reduced hemoglobin and oxygenated hemoglobin.
  • control unit 140 includes at least one processor 141 that controls and manages the entire measurement apparatus 100 including each functional block of the measurement apparatus 100.
  • the control unit 140 includes at least one processor 141 such as a CPU (Central Processing Unit) that executes a program that defines a control procedure, and realizes its function.
  • a program is stored in, for example, the storage unit 160 or an external storage medium connected to the measurement apparatus 100.
  • the at least one processor 141 is implemented as a single integrated circuit (IC) or as a plurality of communicatively connected integrated circuits ICs and / or discrete circuits (discrete circuits). Also good.
  • the at least one processor 141 can be implemented according to various known techniques.
  • the processor 141 includes one or more circuits or units configured to perform one or more data computation procedures or processes, for example, by executing instructions stored in associated memory.
  • the processor 141 may be firmware (eg, a discrete logic component) configured to perform one or more data computation procedures or processes.
  • the processor 141 may include one or more processors, controllers, microprocessors, microcontrollers, application specific integrated circuits (ASICs), digital signal processors, programmable logic devices, field programmable gate arrays, or the like. Any combination of these devices or configurations, or other known devices or configuration combinations may be included, and the function as the control unit 140 described below may be executed.
  • ASICs application specific integrated circuits
  • the control unit 140 calculates a value related to each blood flow rate based on outputs from the first light receiving unit 131 and the second light receiving unit 132 (that is, photoelectric conversion signals of scattered light).
  • a value based on the output from the first light receiving unit 131 is referred to as a first value
  • a value based on the output from the second light receiving unit 132 is referred to as a second value.
  • the control unit 140 can calculate the first value and the second value using the Doppler shift.
  • the control unit 140 When the control unit 140 measures the first value and the second value, the control unit 140 emits laser light from the light emitting unit (that is, the first laser light source 121 and the second laser light source 122) into the tissue of the living body, and receives the light receiving unit. (Ie, the first light receiving unit 131 and the second light receiving unit 132) receive the scattered light scattered from the living tissue. And the control part 140 calculates a 1st value and a 2nd value based on the measurement result of the received laser beam.
  • the light emitting unit that is, the first laser light source 121 and the second laser light source 122
  • the control unit 140 receives the scattered light scattered from the living tissue.
  • the control part 140 calculates a 1st value and a 2nd value based on the measurement result of the received laser beam.
  • the control unit 140 detects a beat signal (also referred to as a beat signal) generated by light interference between scattered light from a stationary tissue and scattered light from a moving blood cell.
  • This beat signal represents the intensity as a function of time.
  • the control part 140 makes this beat signal the power spectrum which represented power as a function of frequency.
  • the Doppler shift frequency is proportional to the blood cell velocity, and the power corresponds to the amount of blood cells. Then, the control unit 140 calculates the first value and the second value by integrating the power spectrum of the beat signal over the frequency.
  • the second value P2 K ⁇ ⁇ f ⁇ P (f) df / (I ⁇ I)
  • P2 ⁇ f ⁇ P (f) df / (I ⁇ I)
  • the first value indicates a value based on the flow rate of oxygenated hemoglobin.
  • the second value indicates a value based on the flow rate of the entire hemoglobin in the blood. Since the value calculated based on the flow rate of the entire hemoglobin in the blood is the blood flow rate of the subject, the second value indicates the blood flow rate of the subject. Therefore, the control unit 140 can calculate the blood flow rate of the subject by calculating the second value. In this way, the measuring device 100 can measure the blood flow of the subject.
  • the control unit 140 calculates the subject's SpO 2 based on the first value and the second value.
  • the control unit 140 can calculate SpO 2 based on the ratio of the first value to the second value.
  • SpO 2 is calculated by the mathematical formula ⁇ HbO 2 / (Hb + HbO 2 ) ⁇ ⁇ 100 when the amount of oxygenated hemoglobin is HbO 2 and the amount of reduced hemoglobin is Hb (see, for example, Patent Document 1).
  • HbO 2 represents the amount of oxygenated hemoglobin
  • Hb + HbO 2 represents the sum of the amounts of oxygenated hemoglobin and reduced hemoglobin.
  • HbO 2 can be associated with the first value calculated based on the flow rate of oxygenated hemoglobin, and (Hb + HbO 2 ) is calculated based on the total flow rate of hemoglobin in the blood. Can be associated with the second value. Accordingly, in the above equation, replace HbO 2 to a first value, when the (Hb + HbO 2) was replaced by the second value, the index showing the SpO 2 is for example, (first value / second value) It can be calculated by a mathematical formula of ⁇ 100. In the present embodiment, the control unit 140 calculates an index indicating SpO 2 using a mathematical formula of (first value / second value) ⁇ 100.
  • the measuring apparatus 100 can measure the subject's SpO 2 .
  • it is an index indicating SpO 2 that can be calculated by a mathematical formula of (first value / second value) ⁇ 100.
  • (first value / second value) ⁇ 100 may be set as SpO 2 as it is, or the value of (first value / second value) is multiplied by a predetermined weighting operation, for example, a coefficient.
  • the value obtained by the calculation may be the SpO 2
  • Control unit 140 is further based on the blood flow and SpO 2 of calculated subject may estimate the likelihood that the subject is altitude sickness (also called disability). Altitude sickness is likely to develop when SpO 2 decreases or dehydration tends to occur. When the subject has a tendency to dehydrate, there is a case where water in the blood is insufficient and blood flow is deteriorated (blood flow volume is reduced). Control unit 140, based on the change in the blood flow and the SpO 2, can be estimated the likelihood that the subject is altitude sickness. The control unit 140 may estimate the possibility of altitude sickness, for example, by weighting the blood flow rate and SpO 2 using a predetermined algorithm.
  • the measuring apparatus 100 since it is possible to measure the SpO 2 and blood flow rate, based on two indices of SpO 2 and blood flow rate, it can be estimated the potential to be altitude sickness. Therefore, according to the measuring apparatus 100 according to this embodiment, as compared with the case of estimating the possibility of altitude sickness only SpO 2, increases the accuracy of estimating the possibility of altitude sickness.
  • the notification unit 150 notifies information using sound, vibration, images, and the like.
  • the notification unit 150 may include a speaker, a vibrator, and a display device.
  • the display device can be, for example, a liquid crystal display (LCD), an organic EL display (OELD), an inorganic EL display (IELD), or an organic EL-Luminescence Display.
  • Notification unit 150 may notify the example SpO 2 and / or blood flow measurement of.
  • reporting part 150 may alert
  • the storage unit 160 can be configured by a semiconductor memory, a magnetic memory, or the like.
  • the storage unit 160 stores various information or a program for operating the measurement apparatus 100.
  • the storage unit 160 may function as a work memory.
  • the storage unit 160 may store, for example, the subject's SpO 2 and blood flow calculated by the control unit 140 as history information.
  • the control unit 140 may repeatedly execute the flow illustrated in FIG. 3 when the measurement apparatus 100 is activated or when a predetermined operation input for starting the measurement process is performed.
  • the control unit 140 has a function capable of detecting whether or not the test site is in contact with the measurement unit
  • the control unit 140 illustrated in FIG. 3 determines that the test site is in contact with the measurement unit.
  • a flow may be executed.
  • the controller 140 emits the first laser light from the first laser light source 121 (step S101).
  • the control unit 140 emits the second laser light from the second laser light source 122 (step S102).
  • the first light receiving unit 131 and the second light receiving unit 132 receive the scattered light from the test site, respectively.
  • the first light receiving unit 131 and the second light receiving unit 132 transmit the photoelectric conversion signal of the scattered light to the control unit 140.
  • the control unit 140 acquires outputs from the first light receiving unit 131 and the second light receiving unit 132 (step S103).
  • the control unit 140 calculates a first value based on the output acquired from the first light receiving unit 131, and calculates a second value based on the output acquired from the second light receiving unit 132 (step S104). .
  • Control unit 140 based on the first value and second value calculated in step S104, and calculates an index indicating the SpO 2, and calculates the SpO 2 from the index shown in SpO 2 (step S105).
  • the control unit 140 estimates the possibility that the subject will suffer from altitude sickness based on the blood flow rate (that is, the second value) and SpO 2 (step S106).
  • the control unit 140 notifies the information such as the calculated blood flow volume and SpO2 and the possibility of becoming an altitude sickness from the notification unit 150 (step S107).
  • the measuring apparatus 100 emits laser light to the test site, and the first value and the second value are based on the received light intensity of the scattered light of the laser light from the test site. And calculate.
  • the measuring apparatus 100 calculates SpO 2 based on the first value and the second value.
  • the laser beam is used for obtaining the biometric measurement output. Since the laser light has high directivity and has the same wavelength and phase, the measurement apparatus 100 has a higher measurement accuracy of SpO 2 than the case of using light of a wide wavelength band, for example, which is not laser light. improves. Thus, according to the measuring apparatus 100, usability improves.
  • the blood flow rate and SpO 2 can be measured with one apparatus. Therefore, there is no need to measure the blood flow volume and SpO 2 with separate devices, and convenience and usefulness are increased by the subject.
  • FIG. 4 is a functional block diagram showing a schematic configuration of the measuring apparatus 200 according to the second embodiment.
  • the measuring apparatus 200 according to the present embodiment includes a biological sensor 210, a control unit 240, a notification unit 250, and a storage unit 260.
  • the biological sensor 110 includes two light receiving parts, the first light receiving part 131 and the second light receiving part 132, whereas the measuring apparatus 200 according to the second embodiment is a living body. It differs from the measuring apparatus 100 according to the first embodiment in that the sensor 210 includes only one light receiving unit 230.
  • the biosensor 210 includes two light emitting units, the first laser light source 221 and the second laser light source 222, and one light receiving unit 230.
  • the functions of the first laser light source 221 and the second laser light source 222 are the same as those of the first laser light source 121 and the second laser light source 122 in the first embodiment, respectively. That is, the first laser light source 221 emits the first laser light, and the second laser light source 222 emits the second laser light.
  • the first laser light source 221 and the second laser light source 222 emit the first laser light and the second laser light at different timings.
  • the first laser light source 221 and the second laser light source 222 alternately output laser light. That is, in the measurement process by the measuring apparatus 200, the first laser beam and the second laser beam are alternately emitted to the test site, for example, every predetermined time.
  • the light receiving unit 230 is configured by, for example, a so-called multi-frequency compatible PD capable of detecting light having a wavelength of scattered light of both the first laser light (red light) and the second laser light (near infrared light). The Therefore, the light receiving unit 230 detects the scattered light of the first laser light when the first laser light is emitted to the test site, and when the second laser light is emitted to the test site, Scattered light of the second laser light is detected.
  • the biosensor 210 transmits a photoelectric conversion signal of scattered light received by the light receiving unit 230 to the control unit 240.
  • FIG. 5 is a schematic diagram for explaining an example of a usage state of the measuring apparatus 200.
  • the light receiving unit 230 receives the scattered light from the test site of the first laser light emitted from the first laser light source 221 and the first laser light emitted from the second laser light source 222. Two laser beams scattered light from the test site is received. Since the first laser light and the second laser light are alternately emitted as described above, the light receiving unit 230 receives the scattered light alternately. Accordingly, FIG. 5 shows the first laser beam, the second laser beam, and the scattered light thereof, but in actuality, at any point in time, either the first laser beam or the second laser beam is covered. The light receiving unit emits scattered light of the emitted laser light. In the measuring apparatus 200, the light receiving unit 230 is disposed at a position where the scattered light of the laser light emitted from the first laser light source 221 and the second laser light source 222 can be received.
  • control unit 240 includes at least one processor 241 that controls and manages the entire measurement apparatus 200 including each functional block of the measurement apparatus 200.
  • the functions of the control unit 240 and the processor 241 are the same as those of the control unit 140 and the processor 141 of the first embodiment, respectively, and thus detailed description thereof is omitted here. Since the functions of the notification unit 250 and the storage unit 260 are also the same as those of the notification unit 150 and the storage unit 160 of the first embodiment, detailed description thereof is omitted here.
  • the blood flow volume and SpO 2 are measured by the control unit 240 according to the same flow as that described with reference to FIG. 3, and the possibility of the subject becoming altitude sickness is estimated.
  • the control unit 240 acquires the output from the light receiving unit 230 in step S103.
  • the control unit 240 determines whether the acquired output from the light receiving unit 230 is scattered light of the first laser or scattered light of the second laser light. Calculate the value.
  • the measuring apparatus 200 since the measuring apparatus 200 according to the present embodiment also calculates the SpO 2 by emitting the laser beam to the test site, for example, compared to the case where light in a wide wavelength band is used, the measurement accuracy of the SpO 2 Will improve. Thus, according to the measuring apparatus 200, usability improves.
  • the measuring apparatus 200 according to the present embodiment can receive the scattered light of the first laser light and the second laser light with one light receiving unit 230 that supports multi-frequency. Therefore, the biosensor 210 and the measuring apparatus 200 can be reduced in size compared to the case where the scattered light of the first laser light and the second laser light is received by two different light receiving units.
  • FIG. 6 is a functional block diagram illustrating a schematic configuration of a measurement system 300 according to the third embodiment.
  • the measurement system 300 includes a measurement device 400, an information processing device 500, and a terminal device 600.
  • the information processing apparatus 500 is communicably connected to the measurement apparatus 400 and the terminal apparatus 600 by wired, wireless, or a combination of wired and wireless.
  • the measurement device 400 and the terminal device 600 may be able to communicate directly.
  • the network that connects the measuring device 400, the information processing device 500, and the terminal device 600 to each other may be the Internet or a wireless LAN.
  • the measuring device 400 is a device that measures a biometric output by injecting laser light to a region to be examined.
  • the measurement apparatus 400 may transmit information regarding the measured biometric measurement output to the information processing apparatus 500.
  • the information processing apparatus 500 can be configured as a server apparatus such as a computer.
  • the information processing apparatus 500 may calculate the blood flow volume and SpO 2 of the subject based on information on the biometric measurement output acquired from the measurement apparatus 400.
  • the information processing apparatus 500 may estimate the possibility that the subject will suffer from altitude sickness.
  • the information processing apparatus 500 may store information related to the blood flow volume and the calculation result of SpO 2 and the estimated possibility of becoming an altitude sickness.
  • the information processing apparatus 500 may transmit information regarding the blood flow volume and the SpO 2 calculation result and the estimated possibility of becoming an altitude sickness to the terminal apparatus 600.
  • the terminal device 600 may be configured as a personal computer, a smartphone, a tablet, or the like, for example.
  • the terminal device 600 may be owned by the subject, for example.
  • the terminal device 600 may perform notification based on the blood flow obtained from the information processing device 500, the calculation result of SpO 2 , and information regarding the estimated possibility of becoming an altitude sickness.
  • the measuring apparatus 400 includes a biological sensor 410, a control unit 440, a notification unit 450, and a storage unit 460.
  • the biological sensor 410 includes a first laser light source 421, a second laser light source 422, a first light receiving unit 431, and a second light receiving unit 432.
  • the functions of the first laser light source 421, the second laser light source 422, the first light receiving unit 431, and the second light receiving unit 432 are the first laser light source 121, the second laser light source 122, and the first light receiving unit in the first embodiment, respectively. 131 and the second light receiving unit 132.
  • the measurement apparatus 400 in the present embodiment can acquire a biometric output in the same manner as the measurement apparatus 100 in the first embodiment.
  • the control unit 440 includes at least one processor 441 that controls and manages the entire measurement apparatus 400 including each functional block of the measurement apparatus 400.
  • the control unit 440 includes at least one processor 441 such as a CPU that executes a program that defines a control procedure, and realizes its function. Such a program is stored in, for example, the storage unit 460 or an external storage medium connected to the measurement apparatus 400.
  • the processor 441 may have the same configuration as that of the processor 441 shown in the first embodiment, for example, and detailed description thereof is omitted here.
  • the control unit 440 controls acquisition of the biological measurement output by the biological sensor 410 and transmits information related to the acquired biological measurement output to the information processing apparatus 500 via the communication unit 470.
  • the storage unit 460 can be composed of a semiconductor memory or a magnetic memory.
  • the storage unit 460 stores various information and / or a program for operating the measurement apparatus 400.
  • the storage unit 460 may function as a work memory.
  • the storage unit 460 may store data such as information related to the biological measurement output acquired by the biological sensor 410 (that is, the received light intensity of scattered light).
  • the communication unit 470 performs transmission / reception of various information by performing wired communication or wireless communication with the information processing device 500 or a combination of wired communication and wireless communication.
  • the communication unit 570 transmits information related to the biometric measurement output measured by the measurement apparatus 400 to the information processing apparatus 500.
  • the information processing apparatus 500 includes a control unit 540, a storage unit 560, and a communication unit 570.
  • the control unit 540 includes at least one processor 541 that controls and manages the entire information processing apparatus 500 including each functional block of the information processing apparatus 500.
  • the control unit 540 includes at least one processor 541 such as a CPU that executes a program that defines a control procedure, and realizes its function. Such a program is stored in, for example, the storage unit 560 or an external storage medium connected to the information processing apparatus 500.
  • the processor 541 may have a configuration similar to that of the processor 141 shown in the first embodiment, for example, and thus detailed description thereof is omitted here.
  • the control unit 540 may calculate the blood flow rate and SpO 2 of the subject based on the information related to the biological measurement output acquired from the measurement device 400.
  • the control unit 540 may estimate the possibility that the subject will have altitude sickness.
  • the details of the blood flow volume and SpO 2 calculation method by the control unit 540 and the details of the estimation method for the possibility of becoming an altitude sickness are the same as those described in the first embodiment, and thus the description thereof is o
  • the storage unit 560 can be configured by a semiconductor memory, a magnetic memory, or the like.
  • the storage unit 560 stores various information and / or a program for operating the information processing apparatus 500.
  • the storage unit 560 may function as a work memory.
  • storage part 560 may memorize
  • Storage unit 560 calculates the blood flow and SpO 2 by the control unit 540, as well as various information used to estimate the possibility of altitude sickness may be stored.
  • the communication unit 570 transmits and receives various types of information by performing wired communication or wireless communication or a combination of wired communication and wireless communication with the measurement apparatus 400 and the terminal device 600.
  • the communication unit 570 receives information related to biometric output from the measurement device 400.
  • the communication unit 570 transmits the blood flow volume and SpO 2 calculated by the information processing apparatus 500 and information related to the possibility of altitude sickness to the terminal device 600.
  • the terminal device 600 includes a control unit 640, a notification unit 650, a storage unit 660, a communication unit 670, and an input unit 680.
  • the control unit 640 includes at least one processor 641 that controls and manages the entire terminal device 600 including each functional block of the terminal device 600.
  • the control unit 640 includes at least one processor 641 such as a CPU that executes a program that defines a control procedure, and realizes its function. Such a program is stored in the storage unit 660 or an external storage medium connected to the terminal device 600, for example.
  • the processor 641 may have the same configuration as that of the processor 141 shown in the first embodiment, for example, and detailed description thereof is omitted here.
  • the control unit 640 may notify the information regarding the blood flow volume and SpO 2 acquired from the information processing apparatus 500 and the possibility of becoming an altitude sickness from the notification unit 650.
  • the notification unit 650 notifies information using sound, vibration, images, and the like. Since the function and configuration of the notification unit 650 may be the same as those of the notification unit 150 described in the first embodiment, detailed description thereof is omitted here.
  • the storage unit 660 can be configured by a semiconductor memory, a magnetic memory, or the like.
  • the storage unit 660 stores various information and / or programs for operating the terminal device 600.
  • the storage unit 660 may function as a work memory.
  • Storage unit 660 for example, blood flow and SpO 2 acquired from the information processing apparatus 500, and may store information about the possibility of altitude sickness.
  • the communication unit 670 transmits and receives various types of information by performing communication with the information processing apparatus 500 by wired communication or wireless communication, or a combination of wired communication and wireless communication. For example, the communication unit 670 receives information regarding the blood flow rate, SpO 2 , and the possibility of becoming an altitude sickness from the information processing apparatus 500.
  • the input unit 680 receives an operation input from a user (for example, a subject) of the terminal device 600 and includes, for example, an operation button (operation key).
  • the input unit 680 may be configured by a touch panel, and an operation key that receives an operation input from the user may be displayed on a part of the display device to receive a touch operation input by the user.
  • FIG. 7 is a sequence diagram illustrating an example of a control procedure performed by the measurement system 300.
  • the process illustrated in FIG. 7 is executed, for example, when the measurement apparatus 400 is activated or when a predetermined operation input for starting the measurement process is performed.
  • the control unit 440 of the measurement apparatus 400 has a function capable of detecting whether or not the test site is in contact with the measurement unit, when it is determined that the test site is in contact with the measurement unit, The process shown in FIG. 7 may be executed.
  • the measuring apparatus 400 emits the first laser light from the first laser light source 421 (step S201).
  • the measuring apparatus 400 emits the second laser light from the second laser light source 422 (step S202).
  • the measuring apparatus 400 acquires biometric measurement outputs from the first light receiving unit 431 and the second light receiving unit 432 (step S203).
  • the measuring apparatus 400 transmits information related to the biometric measurement output to the information processing apparatus 500 via the communication unit 470 (step S204).
  • the information processing apparatus 500 acquires information related to the biometric measurement output from the measurement apparatus 400, the information processing apparatus 500 calculates the first value and the second value based on the biometric output (step S205).
  • the information processing apparatus 500 calculates SpO 2 based on the first value and the second value calculated in step S205 (step S206).
  • the information processing apparatus 500 estimates the possibility that the subject will have altitude sickness based on the blood flow rate (that is, the second value) and SpO 2 (step S207).
  • the information processing apparatus 500 transmits information such as the blood flow volume, SpO2, and the possibility of altitude sickness to the terminal apparatus 600 via the communication unit 570 (step S208).
  • the terminal device 600 When the terminal device 600 acquires information such as the blood flow rate and SpO 2 , and the possibility of becoming an altitude sickness from the information processing device 500, the terminal device 600 obtains information such as the blood flow rate and SpO 2 and the possibility of becoming an altitude sickness. Then, the notification is made from the notification unit 650 (step S209).
  • the biosensor 410 of the measurement apparatus 400 has the same configuration as the biosensor 110 of the first embodiment has been described.
  • the biosensor 410 may have the same configuration as the biosensor 210 of the second embodiment.
  • the information processing apparatus 500 calculates the blood flow volume and SpO 2 and estimates the possibility of becoming altitude sickness.
  • the measurement apparatus 200 calculates the blood flow volume and SpO 2 , and Takayama. You may perform the estimation process of the possibility of becoming sick.
  • the measurement apparatus 400 may transmit the blood flow volume and the SpO 2 calculation result, and the estimation result of the possibility of becoming altitude sickness to the information processing apparatus 500.
  • the measurement system 300 may not include the information processing apparatus 500.
  • the measurement apparatus 400 may transmit the blood flow volume and the SpO 2 calculation result and the estimation result of the possibility of becoming altitude sickness to the terminal apparatus 600.
  • the SpO 2 is calculated by emitting the laser light to the test site, and therefore, for example, SpO 2 is compared with a case where light in a wide wavelength band is used. Improved measurement accuracy. Thus, according to the measurement system 300, usability is improved.
  • the measurement devices (measurement devices 100, 200, and 400) described in the above embodiments can be mounted on various devices.
  • the measuring device 100, 200, or 400 may be mounted on a cerebral blood flow meter that measures cerebral blood flow.
  • a cerebral blood flow meter is a device that measures cerebral blood flow by emitting laser light to the brain.
  • a subject uses a band-shaped measurement member wrapped around the head.
  • the measuring device 100, 200 or 400 may be mounted on a measuring member.
  • the subject activates the cerebral blood flow meter 700 with the measurement member of the cerebral blood flow meter 700 wound around the head.
  • the measuring device 100, 200 or 400 can be activated.
  • the subject can simultaneously perform measurement of cerebral blood flow and measurement of blood flow and SpO 2 .
  • the cerebral blood flow meter 700 can estimate the possibility of the subject having altitude sickness based on the measured cerebral blood flow, blood flow rate, and SpO 2 .
  • the cerebral blood flow meter 700 can estimate the possibility of the subject having altitude sickness based on the measured cerebral blood flow, blood flow rate, and SpO 2 .
  • the measuring device 100, 200, or 400 may be mounted on a sphygmomanometer that measures blood pressure.
  • the sphygmomanometer may be, for example, a well-known upper arm sphygmomanometer that measures blood pressure with the upper arm using a cuff (arm band).
  • the sphygmomanometer 800 is used by the subject with the cuff wrapped around the upper arm.
  • the measuring device 100, 200 or 400 may be mounted on the cuff.
  • the subject When the measuring device 100, 200, or 400 is mounted on the sphygmomanometer 800, the subject activates the sphygmomanometer 800 with the cuff wrapped around the upper arm, and activates the measuring device 100, 200, or 400. can do. As a result, the subject can simultaneously perform blood pressure measurement and blood flow volume and SpO 2 measurement. In this case, the blood pressure meter 800, the measured blood pressure, based on the blood flow and SpO 2, can be estimated the likelihood that the subject is altitude sickness. Thus, as compared with the case of estimating the possibility of altitude sickness only SpO 2, increases the estimation accuracy.
  • the measuring device 100, 200, or 400 may be mounted on a thermometer that measures body temperature.
  • the thermometer 900 measures the skin temperature by bringing it into contact with the human skin.
  • the subject may activate the measuring device 100, 200, or 400 when measuring the body temperature by bringing the thermometer 900 into contact with the skin. it can.
  • the subject can simultaneously perform measurement of body temperature and measurement of blood flow and SpO 2 .
  • the thermometer 900, the measured temperature on the basis of the blood flow and SpO 2 can be estimated the likelihood that the subject is altitude sickness.
  • the measuring device 100, 200 or 400 may be mounted on a device capable of measuring information related to a living body other than the cerebral blood flow meter 700, the sphygmomanometer 800 and the thermometer 900.
  • the control unit of each embodiment has been described as estimating the possibility that the subject will suffer from altitude sickness based on the blood flow rate and SpO 2. However, the control unit of each embodiment is configured to calculate the blood flow rate and SpO 2 . Based on at least one of them, other symptoms such as blood pressure, dehydration, relaxed state, autonomic state, and heart disease may be detected.
  • the test site is described as being a finger, but the test site is not necessarily a finger.
  • the test site may be a wrist, an arm, an ear, a forehead, a neck, a back, a foot, or other sites, or a site where these are arbitrarily combined.
  • FIG. 11 is a diagram schematically illustrating an example of a mounting state of a measuring instrument 1000 including a measuring device that uses a temple as a test site.
  • the measuring instrument 1000 includes two holding parts 1001 and a headband 1002 that couples the two holding parts 1001.
  • the two holding parts 1001 maintain the wearing state by contacting the left and right temples of the subject, respectively, in the wearing state of the measuring instrument 1000.
  • the holding part 1001 may have a shape that does not block the subject's ear when the measuring instrument 1000 is mounted.
  • the holding part 1001 may have a structure that contacts the temple at the upper side of the ear. In this case, since the subject's ear is not blocked even when the measuring instrument 1000 is attached, the subject can hear surrounding sounds. Therefore, it becomes easier to ensure the safety of the subject as compared to the case where the ear of the subject is blocked.
  • the headband 1002 may have an arch shape, for example, as shown in FIG.
  • the measuring instrument 1000 is attached to the subject so that the headband 1002 is located on the top of the head, for example.
  • the headband 1002 may have a mechanism whose length can be adjusted according to the size of the subject's head, for example.
  • the headband 1002 may be configured by a member having rigidity such as stainless steel or carbon fiber.
  • the headband 1002 may maintain the wearing state by pressing the two holding portions 1001 toward the human body in the wearing state of the measuring instrument 1000.
  • At least one of the two holding units 1001 includes a measuring device.
  • the measuring device provided in the holding unit 1001 may be, for example, any of the measuring devices described in the first to third embodiments.
  • maintenance part 1001 is demonstrated below, provided with the measuring apparatus 200 demonstrated in 2nd Embodiment.
  • FIG. 12 is a partial cross-sectional view of the measurement instrument 1000 shown in FIG. 11, and is a cross-sectional view schematically showing a holding unit 1001 including the measurement device 200.
  • the holding unit 1001 includes a measurement device 200.
  • the measurement device 200 includes the first laser light source 221, the second laser light source 222, and the light receiving unit 230.
  • laser light emitted from the first laser light source 221 and the second laser light source 222 is applied to the superficial temporal artery.
  • the light receiving unit 230 receives scattered light with respect to measurement light in the superficial temporal artery.
  • the blood flow rate and SpO 2 are calculated using scattered light in the superficial temporal artery. Since the blood vessels of the superficial temporal artery are thicker than blood vessels such as fingertips, it is easier to obtain biological information. Since blood vessels in the superficial temporal artery are thicker than blood vessels such as fingertips, the blood flow is more stable. Therefore, more accurate blood flow and SpO 2 can be measured by irradiating the superficial temporal artery with measurement light and acquiring biological information.
  • the measuring apparatus 200 may be connected to the headband 1002 via the connection unit 1003.
  • the connection unit 1003 functions as a reduction unit that reduces vibration transmitted from the headband 1002 to the measurement apparatus 200.
  • the connection unit 1003 functions as a damper, for example.
  • the connection portion 1003 may be configured to include an elastic material that can reduce vibration.
  • the connecting portion 1003 may be configured by a spring, rubber, silicone resin, gel, cloth, sponge, paper, other members, or any combination thereof.
  • the connection unit 1003 may be a fluid-filled damper having a fluid (that is, liquid or gas) inside, for example.
  • the internal fluid may be, for example, a viscous liquid.
  • the measuring device included in the holding unit 1001 is not limited to the measuring device 200 described in the second embodiment, and may be, for example, the measuring device 100 described in the first embodiment.
  • One of the two holding units 1001 includes the first laser light source 121 and the first light receiving unit 131 described in the first embodiment, and the other includes the second laser light source 122 and the first laser light source 122 described in the first embodiment. 2 light receiving units 132 may be provided.
  • the biological sensor emits laser light from two laser light sources, the first laser light source and the second laser light source.
  • one of the first laser light source and the second laser light source may be constituted by a light source other than the laser light source, such as an LED (Light Emitting Diode).
  • the LED light source When an LED light source is used instead of the first laser light source, the LED light source emits red light.
  • the LED light source emits near-infrared light.
  • the control unit calculates the first value P1 based on the amount of light received by the first light receiving unit with respect to the amount of light emitted from the LED light source. .
  • the relationship between the ratio of the amount of received light to the amount of emitted light and the first value P1 may be stored in advance in the storage unit as a table, for example. The control unit can calculate the first value P1 with reference to the table.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Cette invention concerne un dispositif de mesure comprenant : une première source de lumière laser qui émet une lumière laser ayant une première longueur d'onde; une seconde source de lumière laser qui émet une lumière laser ayant une seconde longueur d'onde, différente de la première; une unité de réception de lumière qui reçoit la lumière laser diffusée provenant d'un site à examiner; et une unité de commande qui calcule une première valeur en fonction de la sortie générée par l'unité de réception de lumière basée sur la lumière laser diffusée reçue de la première longueur d'onde, calcule une seconde valeur en fonction de la sortie générée par l'unité de réception de lumière basée sur la lumière laser diffusée reçue de la seconde longueur d'onde, et mesure la saturation en oxygène en fonction du rapport de la première valeur à la seconde valeur.
PCT/JP2018/005805 2017-03-08 2018-02-19 Dispositif de mesure, procédé de mesure, et programme associé WO2018163784A1 (fr)

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US16/492,097 US11666228B2 (en) 2017-03-08 2018-02-19 Measuring apparatus, measuring method, and program
EP18764463.8A EP3593719A4 (fr) 2017-03-08 2018-02-19 Dispositif de mesure, procédé de mesure, et programme associé
CN201880016217.8A CN110381830A (zh) 2017-03-08 2018-02-19 测量装置、测量方法以及程序

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JP2017-044077 2017-03-08
JP2017161545A JP6847789B2 (ja) 2017-03-08 2017-08-24 測定装置、測定方法及びプログラム
JP2017-161545 2017-08-24

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Citations (7)

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Publication number Priority date Publication date Assignee Title
JPH0321208Y2 (fr) 1986-11-19 1991-05-09
JPH0415046A (ja) * 1990-05-10 1992-01-20 Kowa Co 血液循環動態の測定方法
JPH0666633U (ja) 1993-02-26 1994-09-20 日本電気三栄株式会社 パルスオキシメータ
JPH07171140A (ja) * 1993-12-21 1995-07-11 Kowa Co 酸素飽和度測定装置
JP2006247133A (ja) * 2005-03-10 2006-09-21 Sharp Corp 生体信号測定装置、生体信号測定方法、およびコンピュータプログラム
JP2007105323A (ja) * 2005-10-14 2007-04-26 Hitachi Ltd 代謝量測定装置
WO2008065699A1 (fr) * 2006-11-27 2008-06-05 Pioneer Corporation Dispositif de capteur d'émission et procédé de détection de bio-informations

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Publication number Priority date Publication date Assignee Title
JPH0321208Y2 (fr) 1986-11-19 1991-05-09
JPH0415046A (ja) * 1990-05-10 1992-01-20 Kowa Co 血液循環動態の測定方法
JPH0666633U (ja) 1993-02-26 1994-09-20 日本電気三栄株式会社 パルスオキシメータ
JPH07171140A (ja) * 1993-12-21 1995-07-11 Kowa Co 酸素飽和度測定装置
JP2006247133A (ja) * 2005-03-10 2006-09-21 Sharp Corp 生体信号測定装置、生体信号測定方法、およびコンピュータプログラム
JP2007105323A (ja) * 2005-10-14 2007-04-26 Hitachi Ltd 代謝量測定装置
WO2008065699A1 (fr) * 2006-11-27 2008-06-05 Pioneer Corporation Dispositif de capteur d'émission et procédé de détection de bio-informations

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Title
See also references of EP3593719A4 *
YASUMA. FUMIHIKO: "Central sleep apnea due to periodic breathing at high altitude", vol. 66, no. 2, 30 April 2008 (2008-04-30), pages 245 - 248, XP009515980, ISSN: 0047-1852 *

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