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WO2018151563A1 - Composition pour prévenir le photovieillissement et soulager les rides de la peau, contenant un extrait de cosmos bipinnatus - Google Patents

Composition pour prévenir le photovieillissement et soulager les rides de la peau, contenant un extrait de cosmos bipinnatus Download PDF

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Publication number
WO2018151563A1
WO2018151563A1 PCT/KR2018/002013 KR2018002013W WO2018151563A1 WO 2018151563 A1 WO2018151563 A1 WO 2018151563A1 KR 2018002013 W KR2018002013 W KR 2018002013W WO 2018151563 A1 WO2018151563 A1 WO 2018151563A1
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WO
WIPO (PCT)
Prior art keywords
skin
cosmos
extract
composition
present
Prior art date
Application number
PCT/KR2018/002013
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English (en)
Korean (ko)
Inventor
박해선
우수정
정광선
김명옥
Original Assignee
스킨큐어 주식회사
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Application filed by 스킨큐어 주식회사 filed Critical 스킨큐어 주식회사
Publication of WO2018151563A1 publication Critical patent/WO2018151563A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to a composition for preventing photoaging and anti-wrinkle including Cosmos ( Cosmos bipinnatus ) extract, more specifically, to enhance collagen synthesis, inhibit collagen degrading enzymes, increase the inhibitory activity by increasing the amount of TIMP-1 expression, skin cell proliferation
  • the present invention relates to a photo-aging and anti-wrinkle cosmetic or pharmaceutical composition comprising a cosmos extract having an effect, an anti-aging effect on skin cell damage by ultraviolet rays, and an anti-aging effect.
  • Endogenous aging is the aging that progresses by decreasing the secretion of various hormones that regulate metabolism internally over time, decreasing the physiological function of cells and reducing the biosynthesis of the elements necessary for living organisms.
  • Exogenous aging is ultraviolet and pollution Aging is caused by external stimuli such as temperature, and various pollutants.
  • collagen which accounts for 90% of the dermal layer of the skin
  • elastin elastic fiber
  • the number and activity of fibroblasts involved in the body is reduced and their amount of synthesis is also reduced. Accordingly, as the amount of water loss in the skin cells increases and the structure of the stratum corneum changes, the activity of collagenase (collagenase) increases, the crosslinking form of collagen increases, skin elasticity, moisturization, etc. decrease, and wrinkles occur.
  • Dermis atrophy that occurs after the age of 70 is a typical aging phenomenon, such as the separation of collagen bundles, reduced polysaccharide synthesis, decreased number and diameter of collagen and elastin, crushing collagen and elastic fibers, and swelling of blood vessels.
  • One object of the present invention is to provide a cosmetic composition for preventing photoaging and / or anti-wrinkle comprising Cosmos extract ( Cosmos bipinnatus ) as an active ingredient.
  • Cosmos extract Cosmos bipinnatus
  • It is another object of the present invention to provide a photoaging preventing and / or anti-wrinkle pharmaceutical composition comprising Cosmos extract ( Cosmos bipinnatus ) as an active ingredient.
  • the present invention provides a composition for improving wrinkles comprising cosmos extract as an active ingredient.
  • Cosmos ( Cosmos bipinnatus ) is a perennial herb belonging to the Asteraceae family, grows up to 1 to 2 m in height and blooms in June-October, and the flowers have various colors such as red, white, and purple. Cosmos is characterized by branching at the top and hairless, with one headpiece at the end of branches and stems.
  • Cosmos extract of the present invention refers to a substance having an activity of improving skin wrinkles extracted from or separated from cosmos outposts, leaves, roots, stems, flowers and the like.
  • cosmos extract refers to all extracts, fractions, purified products, their dilutions, concentrates, dried products or all forms formulated using each extract, fraction, or each step of purification (separation, fraction).
  • Extraction method of the cosmos extract may include cold needle extraction, ultrasonic extraction, reflux cooling extraction method or supercritical extraction method, preferably ultrasonic extraction method.
  • the cosmos extract may be extracted using conventional solvents known in the art, and the extracted liquid may be used in liquid form or concentrated and / or dried.
  • the solvent is water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol, etc.), ethylene, acetone, hexane, ether, ethyl acetate, butyl acetate, chloroform, 1,3-butylene
  • a solvent of any one of glycol, propylene glycol, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), or a mixed solvent thereof can be used.
  • water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol, etc.) or a mixed solvent of water and the lower alcohol is used. More preferably, a mixed solvent of water and methanol is used.
  • the present invention is not limited thereto, and the extraction degree and loss degree of the active ingredient of the extract may vary depending on the organic solvent to be extracted. Therefore, it is preferable to select and use an appropriate organic solvent.
  • the mixed solvent of water and anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms is a mixture of water and the lower alcohol in a weight ratio of 1: 0.1 to 1:10. It is preferably mixed in a weight ratio of 1: 0.2 to 1: 9.
  • the cosmos extract included in the composition of the present invention increases TI collagen synthesis in skin cells, inhibits matrix metaloproteinase-1 (MMP-1) collagen degrading enzyme, and inhibits the activity of MMP-1 collagen degrading enzyme.
  • MMP-1 matrix metaloproteinase-1
  • Tissue Inhibitors of Metalloproteinase-1) increases the expression level, thereby improving the skin wrinkles.
  • the present invention provides a composition for preventing photoaging comprising the cosmos extract as an active ingredient.
  • the cosmos extract contained in the composition for preventing photoaging of the present invention is as described above, the cosmos extract is a material having a photoaging prevention activity extracted from or separated from the outpost, leaves, roots, stems, flowers and the like of cosmos.
  • photoaging prevention protects the skin from skin damage caused by external factors such as ultraviolet rays, and prevents skin aging caused by ultraviolet rays and skin aging such as sagging of the skin and wrinkle formation of the skin. It is to suppress.
  • the external factors such as ultraviolet rays include stress and external harmful chemicals, etc. in addition to ultraviolet rays, the factors may generate free radicals (eg, hydroxyl radicals, superoxide radicals, active oxygen and hydrogen peroxide) to the skin.
  • free radicals eg, hydroxyl radicals, superoxide radicals, active oxygen and hydrogen peroxide
  • oxidative stress causes inflammation, skin cell death and skin cell DNA damage, resulting in skin cancer or aging of the skin.
  • the skin damage means that the skin does not perform its normal function, including damage to the skin constituents (such as collagen and elastin), impaired function of skin cells and death of skin cells, etc. do.
  • the skin cells include all cells present in the skin, preferably keratinocytes and fibroblasts.
  • skin protection includes preventing damage to the skin and improving damaged skin.
  • Cosmos extract contained in the composition of the present invention inhibits the expression of MMP-1 in the skin cells damaged by ultraviolet light, increases the cell survival rate by protecting the skin cells damaged by ultraviolet light, collagen in the skin cells damaged by ultraviolet light And anti-aging effects such as preventing cell aging by inhibiting destruction of elastin fibers.
  • the composition of the present invention is provided as a cosmetic composition for preventing photoaging or improving skin wrinkles.
  • the cosmetic composition of the present invention may include the cosmos extract as an active ingredient in an amount of 0.00001 to 15.0% by weight, preferably 0.0001 to 10% by weight, more preferably 0.0001 to 5% by weight, based on the total weight of the total cosmetic composition. . If the content is less than 0.0001% by weight can not be expected to improve the skin wrinkles and prevent photoaging, when the content exceeds 15.0% by weight the difference between the wrinkle improvement effect and photoaging prevention is insignificant or difficult to prepare a formulation.
  • the cosmetic composition may further include components commonly used in cosmetic compositions in addition to cosmos extract.
  • it may include conventional auxiliaries and carriers such as antioxidants, stabilizers, solubilizers, vitamins, pigments and agents.
  • the cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art.
  • it may be formulated as a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation or spray, and the like.
  • it may be prepared in a formulation such as nourishing cream, astringent lotion, flexible lotion, lotion, essence, nourishing gel or massage cream.
  • nourishing cream astringent lotion, flexible lotion, lotion, essence, nourishing gel or massage cream.
  • it is not particularly limited to this.
  • the formulation of the cosmetic composition is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, trakant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide are used as carrier components.
  • animal oil, vegetable oil, wax, paraffin, starch, trakant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide are used as carrier components.
  • animal oil vegetable oil, wax, paraffin, starch, trakant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide
  • trakant cellulose derivative
  • polyethylene glycol silicone
  • bentonite silica
  • the formulation of the cosmetic composition is a powder or a spray
  • lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, and in the case of a spray, additionally chlorofluorohydrocarbon, Propellant such as propane / butane or dimethyl ether.
  • a solvent, a solubilizer or an emulsifier may be used as a carrier component.
  • a solvent, a solubilizer or an emulsifier may be used as a carrier component.
  • water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid ester can be used. have.
  • a liquid diluent such as water, ethanol or propylene glycol
  • a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester as a carrier component, Crystalline cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.
  • the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid.
  • Amide ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.
  • the cosmetic composition of the present invention prevents and inhibits skin cell damage caused by ultraviolet rays, thereby exhibiting an anti-aging effect.
  • Test Example 4 Determination of the Protective Effect of Cosmos Extracts Against Collagen Damage in Ultraviolet Irradiated Cells
  • the composition of the nourishing cream containing cosmos extract is shown in Table 1 below.
  • the aqueous phase purified water, triethanol amine and propylene glycol were heated and dissolved at 70 ⁇ ⁇ , and the oily fatty acid, oil component, emulsifier, and preservative were heated to 70 ⁇ ⁇ to dissolve the solution. After emulsification was completed the solution was cooled to 45 ° C., cosmos extract and flavor were added and dispersed and then cooled to 30 ° C.
  • Comparative example 1 Preparation of nourishing cream without cosmos extract
  • the composition of the nutrient cream not containing cosmos extract is shown in Table 2 below.
  • the aqueous phase purified water, triethanol amine and propylene glycol were heated and dissolved at 70 ⁇ ⁇ , and the oily fatty acid, oil component, emulsifier, and preservative were heated to 70 ⁇ ⁇ to dissolve the solution. After emulsification was completed, the solution was cooled to 45 ° C., purified water and flavor were added and dispersed, and then cooled to 30 ° C.
  • Wrinkle improvement effect of the cosmetic containing the cosmos extract was measured through clinical trials.
  • the anti-wrinkle effect was evaluated by measuring the change in skin elasticity.
  • Test Example 8 the nutrition creams of Example 2 to 4 (nutrition creams containing 0.01 wt%, 0.05 wt% and 1.00 wt% of cosmos extract) and comparative examples Nourishing cream of 1 was used.
  • Example 2 (0.01%)
  • Example 3 (0.05%)
  • Examples 2 to 4 of the present invention was much better skin elasticity than Comparative Example 1, the skin elasticity was shown to increase with increasing the concentration of the cosmos extract concentration-dependent wrinkle improvement It was found that the effect was improved.
  • tablets were prepared by tableting according to a conventional method for producing tablets.
  • the capsule was prepared by filling in gelatin capsules according to the conventional method for producing a capsule.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une composition pour améliorer l'état de la peau, contenant un extrait de Cosmos bipinnatus. L'extrait de Cosmos bipinnatus, qui est utilisé en tant que principe actif dans la composition de la présente invention, a un excellent effet d'atténuation des rides par l'intermédiaire d'un mécanisme moléculaire tel que la promotion de la synthèse de collagène et l'action de protection des fibroblastes, empêche les lésions cutanées provoquées par une irradiation ultraviolette de façon à empêcher le photovieillissement, et est non cytotoxique et présente une excellente innocuité pour la peau, ce qui peut être utilisé dans un produit cosmétique ou une composition pharmaceutique.
PCT/KR2018/002013 2017-02-20 2018-02-19 Composition pour prévenir le photovieillissement et soulager les rides de la peau, contenant un extrait de cosmos bipinnatus WO2018151563A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0022330 2017-02-20
KR1020170022330A KR20180096094A (ko) 2017-02-20 2017-02-20 코스모스 추출물을 포함하는 피부주름 개선용 조성물

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WO2018151563A1 true WO2018151563A1 (fr) 2018-08-23

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PCT/KR2018/002013 WO2018151563A1 (fr) 2017-02-20 2018-02-19 Composition pour prévenir le photovieillissement et soulager les rides de la peau, contenant un extrait de cosmos bipinnatus

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102504441B1 (ko) 2022-03-04 2023-02-28 엘앤피코스메틱(주) 코스모스 유래 유산균 및 세이지 추출물을 포함하는 유산균 첨가제의 제조방법 및 이를 포함하는 화장료 조성물의 제조방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060018867A1 (en) * 2004-05-12 2006-01-26 Ichimaru Pharcos Co., Ltd Cosmetic composition and production thereof
KR20160077701A (ko) * 2014-12-24 2016-07-04 주식회사 유니솔브 층꽃나무 추출물을 함유하는 항산화, 미백 및 주름 개선을 위한 조성물

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060018867A1 (en) * 2004-05-12 2006-01-26 Ichimaru Pharcos Co., Ltd Cosmetic composition and production thereof
KR20160077701A (ko) * 2014-12-24 2016-07-04 주식회사 유니솔브 층꽃나무 추출물을 함유하는 항산화, 미백 및 주름 개선을 위한 조성물

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JANG, IN-CHEOL ET AL.: "Antioxidative and Antigenotoxic Activity of Extracts from Cosmos (Cosmos bipinnatus) Flowers", PLANT FOODS FOR HUMAN NUTRITION, vol. 63, no. 4, 2008, pages 205 - 210, XP019648498 *
KIM, SUN YOUNG ET AL.: "Evaluations of Antioxidative Activity and Whitening Effect of Extracts from Different Parts of Cosmos bipinnatus", JOURNAL OF THE KOREAN OIL CHEMISTS' SOCIETY, vol. 27, no. 4, 2010, pages 559 - 567 *
WOO, JEONG HYANG ET AL.: "Antioxidant Effect According to Extraction Method in Extracts of Dendranthema Zawadskii var. Yezoense and Cosmos bipinnatus", HORTICULTURAL SCIENCE AND TECHNOLOGY, vol. 28, no. 3, 2010, pages 462 - 468, XP055535275 *

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