+

WO2018150392A1 - Prothèse atrio-ventriculaire à flux asymétrique - Google Patents

Prothèse atrio-ventriculaire à flux asymétrique Download PDF

Info

Publication number
WO2018150392A1
WO2018150392A1 PCT/IB2018/051026 IB2018051026W WO2018150392A1 WO 2018150392 A1 WO2018150392 A1 WO 2018150392A1 IB 2018051026 W IB2018051026 W IB 2018051026W WO 2018150392 A1 WO2018150392 A1 WO 2018150392A1
Authority
WO
WIPO (PCT)
Prior art keywords
leaflet
prosthesis
plane
prosthesis according
atrio
Prior art date
Application number
PCT/IB2018/051026
Other languages
English (en)
Inventor
Enrico Pasquino
Marcio Scorsin
Andrea Marchisio
Lorenzo VALERIO
Original Assignee
Epygon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epygon filed Critical Epygon
Publication of WO2018150392A1 publication Critical patent/WO2018150392A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2002/068—Modifying the blood flow model, e.g. by diffuser or deflector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0037—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in height or in length

Definitions

  • the left ventricle (LV) is the strongest chamber in the human heart that pumps blood to provide oxygen and nutrients to tissues and in the whole body.
  • the intraventricular circulation is a consequence of the asymmetry of the mitral orifice with respect to the ventricular chamber, where the eccentric inflow gives rise to an asymmetric rotatory motion that accompanies the redirection of the rapid flow entering from the mitral valve toward the opposite facing outflow tract. Therefore, the fluid dynamics trough the native mitral valve is characterized by the presence of intraventricular vortex which plays a central role in the global synchronicity of the beating heart.
  • fluid dynamics inside the LV is little or no use in clinical and are not taken into account for the design of prosthetic valves.
  • Asymmetric functional component Different number, shape and size of leaflets can be arranged so as to produce an asymmetric flow. This feature can be achieved by mounting a tissue valve with different leaflet sizes based on the unequal placement of the commissures. With at least two different sizes of tissue leaflets supported by a more posterior commissure, the opening can be modulated so as the flow can be directed towards the LV posterior wall i.e., modulating the angle between the annular attachment and the commissure may be different being the larger leaflet having a greater angle and the smaller leaflet a lesser angle.
  • a bileaflet prosthesis may have the larger leaflet (that corresponds anatomically to the anterior mitral leaflet) covering more than 50% of the surface. Consequently, in this way, it is possible to achieve an asymmetric flow similar to the flow of the native valve.
  • the valve is assembled as a standard multileaflet valvular prosthesis.
  • the design, shape and size of the leaflets may be symmetric, what changes is the plane of closure of the leaflets regarding the inter-annular plan. All mitral bioprosthesis surgically implanted have the plane of closure of the leaflets at the same level of the interannular plane.
  • a not aligned axis is created between the plane of closure of the leaflets and the inter-annular plane.
  • the central flow typical of this type of prosthesis is then directed to the posterior wall of the ventricle, consequently allowing the formation of an asymmetric (not central) intraventricular flow.
  • This solution can be applied also for mechanical prosthesis.
  • Figure 1 a (prior art) Symmetric bileaflet prosthesis mounted in a stent frame S, anterior leaflet (AL) and posterior leaflet (PL). With this design, the leaflet's coaptation C occurs in the middle of the stent frame.
  • FIG. 3 Example of a trileaflet prosthesis according to the invention.
  • the plane of closure of the trileaflets a-a is oblique to the interannular plane a-a'. Therefore, the transvalvular flow F generated is asymmetric similar to the native valve.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

La prothèse atrio-ventriculaire à feuillets multiples est caractérisée par le fait qu'elle est conçue pour induire un flux sanguin asymétrique.
PCT/IB2018/051026 2017-02-20 2018-02-20 Prothèse atrio-ventriculaire à flux asymétrique WO2018150392A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IBPCT/IB2017/050957 2017-02-20
IB2017050957 2017-02-20

Publications (1)

Publication Number Publication Date
WO2018150392A1 true WO2018150392A1 (fr) 2018-08-23

Family

ID=61683843

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2018/051026 WO2018150392A1 (fr) 2017-02-20 2018-02-20 Prothèse atrio-ventriculaire à flux asymétrique

Country Status (1)

Country Link
WO (1) WO2018150392A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11039919B2 (en) 2017-10-31 2021-06-22 W. L. Gore & Associates, Inc. Valved conduit
US11351058B2 (en) 2017-03-17 2022-06-07 W. L. Gore & Associates, Inc. Glaucoma treatment systems and methods
US11419717B2 (en) 2017-06-29 2022-08-23 Open Stent Solution Sas Intraluminal support structure and prosthetic valve for the same
USD977642S1 (en) 2018-10-29 2023-02-07 W. L. Gore & Associates, Inc. Pulmonary valve conduit
US11617644B2 (en) 2014-10-13 2023-04-04 W. L. Gore & Associates, Inc. Prosthetic valved conduit
US11678983B2 (en) 2018-12-12 2023-06-20 W. L. Gore & Associates, Inc. Implantable component with socket
US12239573B2 (en) 2018-08-29 2025-03-04 W. L. Gore & Associates, Inc. Drug therapy delivery systems and methods

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013160439A1 (fr) * 2012-04-27 2013-10-31 Epygon Sasu Prothèse de valvule cardiaque
US20160113764A1 (en) * 2014-06-11 2016-04-28 Medtronic Vascular, Inc. Prosthetic Valve With Flow Director
WO2016178126A1 (fr) * 2015-05-05 2016-11-10 The Medical Research Infrastructure And Health Services Fund Of The Tel-Aviv Medical Center Implant de valve atrio-ventriculaire gauche

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013160439A1 (fr) * 2012-04-27 2013-10-31 Epygon Sasu Prothèse de valvule cardiaque
US20160113764A1 (en) * 2014-06-11 2016-04-28 Medtronic Vascular, Inc. Prosthetic Valve With Flow Director
WO2016178126A1 (fr) * 2015-05-05 2016-11-10 The Medical Research Infrastructure And Health Services Fund Of The Tel-Aviv Medical Center Implant de valve atrio-ventriculaire gauche

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PEDRIZZETTI G ET AL.: "On the Left Ventricular Vortex Reversal after Mitral Valve Replacement", ANNALS OF BIOMEDICAL ENGINEERING, vol. 38, 2010, pages 769 - 773, XP019786061

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11617644B2 (en) 2014-10-13 2023-04-04 W. L. Gore & Associates, Inc. Prosthetic valved conduit
US11351058B2 (en) 2017-03-17 2022-06-07 W. L. Gore & Associates, Inc. Glaucoma treatment systems and methods
US11406533B2 (en) 2017-03-17 2022-08-09 W. L. Gore & Associates, Inc. Integrated aqueous shunt for glaucoma treatment
US11523940B2 (en) 2017-03-17 2022-12-13 W. L. Gore & Associates, Inc. Delivery aids for glaucoma shunts
US12150897B2 (en) 2017-03-17 2024-11-26 W. L. Gore & Associates, Inc. Delivery aids for glaucoma shunts
US11419717B2 (en) 2017-06-29 2022-08-23 Open Stent Solution Sas Intraluminal support structure and prosthetic valve for the same
US11039919B2 (en) 2017-10-31 2021-06-22 W. L. Gore & Associates, Inc. Valved conduit
US12186182B2 (en) 2017-10-31 2025-01-07 Edwards Lifesciences Corporation Valved conduit
US12239573B2 (en) 2018-08-29 2025-03-04 W. L. Gore & Associates, Inc. Drug therapy delivery systems and methods
USD977642S1 (en) 2018-10-29 2023-02-07 W. L. Gore & Associates, Inc. Pulmonary valve conduit
US11678983B2 (en) 2018-12-12 2023-06-20 W. L. Gore & Associates, Inc. Implantable component with socket

Similar Documents

Publication Publication Date Title
WO2018150392A1 (fr) Prothèse atrio-ventriculaire à flux asymétrique
US7455689B2 (en) Four-leaflet stented mitral heart valve
EP2991584B1 (fr) Valves prosthétiques
EP2073755B1 (fr) Cadre de montage intra-annulaire pour réparation de valve aortique
US4759759A (en) Bubble heart valve
EP1610722B1 (fr) Appareil de retablissement de la fonction aortique valvulaire et procede de traitement utilisant cet appareil
CN101605511B (zh) 大小逐渐变化的瓣环成形术环
US5163953A (en) Toroidal artificial heart valve stent
US20050228494A1 (en) Controlled separation heart valve frame
JP2016067931A (ja) 心臓弁逆流を治療するための埋め込み型デバイス
AU2005206914A1 (en) Devices and methods for repairing cardiac valves
WO2014201384A1 (fr) Valve mitrale transcathéter
EP3960128A1 (fr) Prothèse de valve cardiaque
JP5392539B2 (ja) ステントレス人工僧帽弁及び人工弁葉
Barratt-Boyes et al. The stentless bioprosthesis: surgical challenges and implications for long-term durability
US20250114192A1 (en) Valve skirts for prosthetic devices
Relland et al. The third generation Carpentier-Edwards bioprosthesis: early results
US20220304801A1 (en) Prosthetic heart valve
CN204909723U (zh) 一种人工生物心脏瓣膜成形环
Kim et al. Aortic valve leaflet replacement with bovine pericardium to preserve native dynamic capabilities of the aortic annulus
WO2025001474A1 (fr) Stent pour prothèse de valvule, et prothèse de valvule
AU2011235960B2 (en) Devices and methods for repairing cardiac valves
Bronzino et al. Cardiac Valve Prostheses
UA123570U (uk) Кільце для анулопластики мітрального клапана
Ribeiro et al. Reconstructive surgery for aortic valve disease

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18711687

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18711687

Country of ref document: EP

Kind code of ref document: A1

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载