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WO2017213597A1 - Procédé de purification de lait maternel et dispositif pour sa mise en œuvre - Google Patents

Procédé de purification de lait maternel et dispositif pour sa mise en œuvre Download PDF

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Publication number
WO2017213597A1
WO2017213597A1 PCT/TR2016/050171 TR2016050171W WO2017213597A1 WO 2017213597 A1 WO2017213597 A1 WO 2017213597A1 TR 2016050171 W TR2016050171 W TR 2016050171W WO 2017213597 A1 WO2017213597 A1 WO 2017213597A1
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WO
WIPO (PCT)
Prior art keywords
milk
nanosurface
infuser
poly
chemical
Prior art date
Application number
PCT/TR2016/050171
Other languages
English (en)
Inventor
Tugba AKBAY
Original Assignee
Akbay Tugba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akbay Tugba filed Critical Akbay Tugba
Priority to PCT/TR2016/050171 priority Critical patent/WO2017213597A1/fr
Publication of WO2017213597A1 publication Critical patent/WO2017213597A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B01J20/28007—Sorbent size or size distribution, e.g. particle size with size in the range 1-100 nanometers, e.g. nanosized particles, nanofibers, nanotubes, nanowires or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
    • B01J2220/49—Materials comprising an indicator, e.g. colour indicator, pH-indicator

Definitions

  • the present invention relates to a method and device for separating unwanted chemicals and their metabolites from breast milk. More particularly, the invention pertains to a novel method and device for the elimination of unsafe compounds found in breast milk by using of nanosurfaces comprising antibodies targeting the chemical compounds whereby removal of these compounds from the breast milk is visualized by the user.
  • Breastfeeding offers health benefits to mother and child even after toddlerhood.
  • These benefits of breastmilk include, for instance decreased risk of sudden infant death syndrome, increased intelligence, decreased likelihood of contracting middle ear infections, cold and flu resistance, a tiny decrease in the risk of childhood leukaemia, lower risk of childhood onset diabetes, decreased risk of asthma and eczema, decreased dental problems, decreased risk of obesity later in life, and a decreased risk of developing psychological disorders, including in adopted children.
  • WO 2004/082558 A2 discloses devices and methods for removal of leukocytes from breast milk whereby a filter is attached to the nipple shield or baby bottle nipple at a location permitting removal of leukocytes.
  • the filters mentioned therein are noted to be leukocyte depletion filters and leukocyte reduction filters which require liquid to pass through the said filters. In other words, the liquid (i.e. breast milk) is forced to pass through very small openings which require excessive pressure.
  • a filter device such as activated carbon and/or a resin that absorbs/adsorbs cations and anions, organic and inorganic toxins, and endocrine disruptors is provided in a nipple shield or within a baby bottle.
  • an object of the present invention is providing a novel device and method for the elimination of chemical moieties that are found in the breast milk and are harmful for the baby's health in a selective manner targeting only the harmful chemical compounds.
  • Another, object of the present invention is providing a novel device and method which does not necessitate filtering of breast milk through a porous structure such as a filter.
  • Another object of the present invention is developing a device and method for removing of harmful chemicals found in the breast milk even in very low amounts (i.e. ng/mL).
  • a further object of the present invention is developing a device and method for removing of unwanted chemicals from breast milk specifically targeting chemicals such as pharmaceutical drugs, agrochemicals, food additives and cosmetics.
  • Still a further object of the present invention is eliminating shortcomings of prior art with a reliable and consistent device visualizing removal of unwanted chemicals from breast milk.
  • a device for removing an unwanted moiety from milk of a mammalian comprises a nanosurface at least a portion of which is combined with at least one antibody targeting said unwanted moiety wherein the antibody is immobilized on the nanosurface and said portion of the nanosurface comprises means for visualizing binding of the chemical or chemical moiety to the antibody.
  • the nanosurface may comprise, for instance, a matrix of polymers, nanofibers, silica beads, aerogels or hydrogels suitable for immobilization of an antibody used in the context of the present invention.
  • the antibody as a specific capturing molecule, recognize and binds its antigen or ligand. Capturing molecules should be covalently attached to the nanosurface by reacting -COOH with -NH 2 groups on said nanosurface.
  • the milk as mentioned herein is preferably human breast milk.
  • the means for visualization as mentioned above comprises preferably a labelling material configured to change colour once the unwanted chemical or chemical moiety is bound to the antibody.
  • the visualization means may include a coloured material selected from the group of a latex, and nanosized particles of gold, carbon, silver, selenium or platinum to be bound to the antibody. Most preferably the material comprises colloidal gold particles.
  • the nanosurface may further comprise lactase and/or an antibacterial agent.
  • the antibacterial agent is preferably selected from the group of chitosan, and an oil or extract of a plant selected from anise, thyme, sage, rosemary and cinnamon.
  • lactase and/or antibacterial agent may be incorporated into a membrane provided with the visualization means as mentioned above.
  • the device according to the present invention can be a receptacle (1) comprising said nanosurface integrally in an inner wall (11) and/or bottom portion (13) thereof.
  • the device can be contemplated as an infuser (2) immersible into milk stored in a receptacle (1) whereby the nanosurface as such constitutes the infuser or the nanosurface is provided in an inner volume of the infuser (2).
  • the infuser (2) comprises an open end portion (21) and a closed bottom portion (22) such that the milk can be poured from the open end portion (21) so that the milk can be contacting with infuser's inner surface and gradually released into a receptacle (1).
  • the infuser (2) is in the form of a bag comprising the nanosurface on its structure or in an inner volume thereof. Still in a further variation, the infuser (2) is of the type a prism or tablet immersible into the milk stored in a receptacle (1). Additionally, the device can be a baby bottle, nipple or nipple shield incorporated with the nanosurface mentioned above. Further, the device can be a filter which can be affixed to a device for feeding an infant.
  • the polymers that can be used in the context of the present invention as the nanosurface may be selected from the group consisting of polyvinyl alcohol (PVA), polyacrylic acid (PAA), methacrylic acids, N-butyl acrylate, N-butyl methacrylate, hexyl acrylate, 2- ethylbutyl acrylate, isooctyl acrylate, 2-ethylhexyl acrylate, decyl acrylate, decyl methacrylate, dodecyl acrylate, dodecyl methacrylate, tridecyl acrylate, tridecyl methacrylatepolyethylene (PE), polyurethane (PU), polycaprolactone, polycarbonate, polytetrafluoroethylene (PTFE), polyacetal (PA), polymethylmethacrylate (PMMA), polyethylene glycols, polyethylene terephthalate (PET), silicone rubber (SR), polysulfone (PS), polylactic acid (
  • the antibody as mentioned in the foregoing explanations is specific to a chemical or chemical moiety that is excreted in to the milk.
  • These chemicals can be selected from antidepressants and antipsychotic drugs, alkaloids, analgesics, immunosuppressant agents, cephalosporins, drugs used for the treatment of respiratory diseases, and metabolites thereof.
  • the present invention relates to a method for removing of a chemical from milk of a mammalian comprising bringing into contact the device as mentioned above with the milk before or during feeding of an infant.
  • the method may further comprise placing of the device against flow of the milk such as the milk from mother or a milk pump.
  • the method may comprise immersion of the device into the milk stored in a receptacle.
  • the invention relates to a method for producing the device as mentioned above, comprising the following steps: providing a nanosurface in the form of a matrix,
  • the polymer matrix comprising antibodies and means for visualization into a device for feeding an infant, or shaping the matrix as a strainer or infuser for treatment of the milk.
  • the antibodies used in the present invention can be monoclonal or polyclonal, or can be obtained from cell lines as conventionally known in the art. Brief Description of the Figures
  • Figure 1 is a perspective view of an embodiment according to the present invention wherein the nanosurface is provided in inner wall and/or bottom surface of a receptacle.
  • Figure 2 is a perspective view of another embodiment according to the present invention wherein the nanosurface is provided as an infuser device fillable with milk from an open end portion and being immersible into the milk inside of a receptacle.
  • Figure 3 is a perspective view of another embodiment according to the present invention wherein the nanosurface is provided as an infuser device in the form of a bag immersible into the milk inside of a receptacle.
  • Figure 4 is a perspective view of another embodiment according to the present invention wherein the nanosurface is provided as an infuser device in the form of a prism or tablet immersible into the milk inside of a receptacle.
  • the present invention provides a novel method and device which involve use of a nanosurface incorporated with antibodies targeting antigens, namely the unsafe organic and inorganic chemical moieties found in the breast milk.
  • the device for separating unwanted compounds from breast milk can be a receptacle such as a baby bottle with or without a nipple, or a breast milk pump comprising said receptacle.
  • the device can be a nipple or nipple shield as such, and in this case, the nanosurface incorporated with antibodies can be conveniently placed into these devices so that the breast milk can be treated in situ within the course of feeding an infant.
  • the device according the present invention can be formed as an infuser as elaborated in preferred embodiments hereinbelow comprising the nanosurfaces according to the instant invention.
  • the nanosurface may comprise, for instance, a matrix of polymers, nanofibers, silica beads, aerogels or hydrogels suitable for immobilization of an antibody used in the context of the present invention.
  • These structures provide a large surface and contact area so that the unwanted chemicals can be easily brought into contact with antibodies and separated from the milk.
  • the present invention advantageously incorporates means for visualizing the removal state of the unwanted chemical substances to the corresponding antibody so that the user may be confident with removal of these substances from the breast milk.
  • This also advantageously ensure that breast milk can be brought into contact with the device for a sufficient time so that the user can recognize removal of the chemical substances properly and then feed the infant with the milk sufficiently treated.
  • This is particularly important because the device of the present invention works with the principle of bringing breast milk into contact with the nanosurface loaded with antibodies, and removing the breast milk before being captured in required concentrations may render the milk insufficiently treated.
  • Means for visualizing as mentioned herein may involve any method and arrangement conventionally known in the art such as labelling of antibodies so that a colour change can be observed once the antibodies bind to specific antigens.
  • ligand-receptor assays available in the art that have been used to detect the presence of various substances in body fluids. These assays involve antigen antibody reactions, synthetic conjugates comprising radioactive, enzymatic, fluorescent, or visually observable metal sol tags, and specially designed reactor chambers.
  • a receptor e.g., an antibody, which is specific for the selected ligand or antigen, and a means for detecting the presence, and often the amount, of the ligand- receptor reaction product.
  • a rapid detection means including a labelling material such as a latex or nanosized particles of gold, carbon, silver, selenium and platinum.
  • a labelling material such as a latex or nanosized particles of gold, carbon, silver, selenium and platinum.
  • latex or nanosized particles are conjugated with antibodies and they cause a change in colour once the antibodies are bound with corresponding antigens.
  • colloidal gold is particularly preferred.
  • the nanosurface used in the device according to the present invention may further comprise lactase for use specifically to treat breast milk for feeding infants lacking lactase.
  • This enzyme can be impregnated to or immobilized on the nanosurface.
  • the device according to the present invention may further comprise an antibacterial agent.
  • the nanosurface of the current invention can therefore become a bactericidal surface which prevents bacterial proliferation. This is particularly advantageous because the device having a bactericidal surface become reusable repeatedly.
  • Natural polymers such as chitosan are known to have antibacterial properties, and therefore a nanosurface made of chitosan for use in the context of the present invention would inherently provide antibacterial properties without the need for including further agents.
  • an antibacterial agent preferably of natural origin such as the oils or extracts of anise, thyme, sage, rosemary, cinnamon or combinations thereof can be used in the nanosurface of the present invention.
  • the nanosurface according to the present invention can be provided within a baby bottle, nipple, nipple shield or any receptacle for the breast milk in any form and location as long as the milky liquid can be brought into contact with the nanosurface containing specific antibodies. It is thus up to the designer to provide suitable embodiments of the invention. However, it would be preferable to provide the nanosurface in an arrangement such that the best possible contact area during the flow or storage of the breast milk can be obtained.
  • the nanosurface can be placed over the inner walls (11) and/or bottom surface (12) of a receptacle (1) (e.g. baby bottle) such that nanosurface and antibodies can be brought into contact with breast milk in a simple manner.
  • the nanosurface as scrutinized in the foregoing explanations can be contemplated in the form of an infuser (2) as shown in Figs. 2, 3 and 4.
  • the infuser (2) shown in Fig. 2 is configured to be placed inside a receptacle (1) from the mouth portion (13) thereof in a manner extending along the inner volume of the receptacle (1) and providing a large contact area with the milk stored therein. It has an open end portion (21) where breast milk can be poured into the inner volume thereof, and a bottom portion (22) which is actually closed.
  • this infuser device (2) can be formed in a porous structure (i.e.
  • the infuser device (2) may directly be placed into a receptacle (1) which is already filled with breast milk, and in this case, breast milk is moved in the reverse direction, i.e. through the inner volume of the infuser device (2). In both of the usage modes, milk is brought into contact with the nanosurface of the infuser device (2) in an efficient way and unwanted chemicals are removed without exerting an extra effort.
  • the infuser device (2) is contemplated as a bag (i.e.
  • tea bag shaped comprising a matrix of the nanosurface which is designed for immersion into the breast milk stored in a receptacle (1) as shown in Fig. 3.
  • nanosurface may constitute the said infuser device (2) or it can be stored within an inner volume of the same. This arrangement also suggests removal of unwanted chemicals without extra effort because of the antibodies immobilized on the nanosurface catching and entrapping of the corresponding unwanted chemicals or moieties and it can be simply immersed into the breast milk in a receptacle (1).
  • Fig. 3 shows a further embodiment as shown in Fig.
  • the infuser device (2) can be provided as a rigid prism or tablet which can be immersed into the receptacle (1) from a mouth portion (13) thereof so that it can be readily brought into contact with the milk stored in the receptacle (1). Similar to the infuser device (2) as shown in Fig. 3, this device also comprise a nanosurface and it can be stored within an inner volume of the same.
  • the nanosurface containing antibodies can be integrated into a device for feeding an infant, such as baby bottles, nipples, nipple shields or milking pumps, or it can be arranged in a disposable manner such as the infuser devices (2) exemplified in the above mentioned embodiments.
  • Providing the nanosurface as a disposable device is advantageous because it suggests simplicity and eliminates the need for regeneration of the nanosurface after treatment of the breast milk.
  • nanosurfaces of the present invention can be designed in the form a conventional filter for screening and treating the breast milk in situ.
  • the present invention is advantageous in that the need for very smaller openings (i.e.
  • the nanosurfaces according to the present invention may comprise, for instance, a matrix of polymers, nanofibers, silica beads, aerogels or hydrogels suitable for immobilization of an antibody.
  • These nanosurfaces are well-known in the art, and are known to be advantageous for immobilization of organic molecules such as peptides, enzymes and antibodies because of their high aspect ratio, large surface area to volume ratio, thermal and chemical stability, high porosity, high directional strength, biocompatibility and biodegradability, good structural morphology and flexibility.
  • mold copying colloidal lithography, interfacial polymerization, nanoprecipitation, multiple solvent emulsion evaporation, nano-identification, electrospray, self-assembly, drawing, phase separation, and electrospinning methods may be used.
  • nanofibers are particularly preferred because they suggest high surface area and are noted to be very suitable for immobilization of antibodies over the surface thereof. This method is also advantageous in obtaining increased porousness and providing antibody /polymer mixture in optimum homogeneity.
  • Nanosurfaces forming a matrix for immobilization of antibodies according to this invention can be made of the polymers which are preferably biocompatible and/or biodegradable polymers and they can be of natural and/or synthetic origin. Synthetic polymers may be selected from homopolymers, heteropolymers or copolymers and terpolymers.
  • Nanostructures may be formed by use of one or a combination from the group of polyvinyl alcohol (PVA), polyacrylic acid (PAA), polyethylene (PE), polyurethane (PU), polycaprolactone, polycarbonate, polytetrafluoroethylene (PTFE), polyacetal (PA), polymethylmethacrylate (PMMA), polyethylene glycols, polyethylene terephthalate (PET), silicone rubber (SR), polysulfone (PS), polylactic acid (PLA), polyglycolic acid (PGA), poly(DTE carbonate), poly(propylene carbonate), polytetrafluoroethylene, polyacetal, polymethylmethacrylate, polyethylene terephthalate, polycaprolactone, polyvinylpyrrolidone, acrylic polymers, alpha hydroxy acid polyester, beta-l,3-glucan, natural rubber, cellulose, Type-I collagen, Type-II collagen, alginate, gelatine, chitosan, fibrinogen, chitin, elastin
  • Heteropolymer or copolymers of the invention can be selected from alternative copolymer, periodic copolymer, statistical copolymer, block copolymer, terpolymer and graft copolymer.
  • Acrylic polymers used in the invention are homopolymer, copolymer, terpolymer and acrylic acid-like polymers.
  • Polyacrylates may be selected from the group containing acrylic acid, methacrylic acid, N-butyl acrylate, N-butyl methacrylate, hexyl acrylate, 2- ethylbutyl acrylate, isooctyl acrylate, 2-ethylhexyl acrylate, decyl acrylate, decyl methacrylate, dodecyl acrylate, dodecyl methacrylate, tridecyl acrylate, tridecyl methacrylate or mixtures thereof.
  • the antibodies used in the context of the present invention can be obtained biologically or by way of synthetic methods as conventionally known in the art.
  • a specific antigen is bonded with a hapten and injected to a rabbit for the production of the corresponding antibody which can be isolated from rabbit's blood later on and used with the nanosurfaces of the present invention.
  • antibodies can be produced by recombinant techniques.
  • antibodies generally are commercially available and they can directly be used depending on the specific chemical moiety targeted in the breast milk.
  • the novel device and method of the present invention is noted to be advantageous for elimination of chemicals such as food additives, cosmetics, hair dyes, agrochemicals, sweeteners, tobacco and drugs, or their metabolites from the breast milk even if they exist in trace amounts while providing the user's confidence by visual means.
  • chemicals such as food additives, cosmetics, hair dyes, agrochemicals, sweeteners, tobacco and drugs, or their metabolites from the breast milk even if they exist in trace amounts while providing the user's confidence by visual means.
  • Various drugs have already been reported to be excreted to breast milk easily and being harmful for the infant. The same holds also various metabolites of tobacco and tobacco products.
  • the present invention ensures elimination of these and other factors harmful for the health of the infant, and therefore the invention is useful for removing any kind of antigen with high efficiency even if the antigen itself exists in very low amounts in the breast milk, thanks to the antibodies immobilized on a nanosurface. This eliminates conventional techniques relying on screening based on molecule size
  • the present invention is particularly suitable for removing unwanted drugs and drug metabolites such as antidepressant and antipsychotic drugs, analgesics, alkaloids, immunosuppressant agents, antibiotics, as well as the drugs widely used in the treatment of respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma from breast milk.
  • unwanted drugs and drug metabolites such as antidepressant and antipsychotic drugs, analgesics, alkaloids, immunosuppressant agents, antibiotics, as well as the drugs widely used in the treatment of respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma from breast milk.
  • COPD chronic obstructive pulmonary disease
  • the means for visualizing removal of the unwanted chemicals advantageously ensures user's confidence and provides also an indication for the user about waiting time necessary for completing the reactions between the chemical substances and antibodies.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
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  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
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  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
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  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Nanotechnology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne un procédé et un dispositif pour séparer des fractions indésirables du lait d'un mammifère à l'aide d'une nanosurface dont au moins une partie est combinée à au moins un anticorps ciblant ladite fraction chimique. La nanosurface comprend en outre des moyens pour visualiser la liaison de la fraction chimique ou du produit chimique indésirable à l'anticorps afin d'assurer la confiance de l'utilisateur et l'utilisation correcte du dispositif selon la présente invention.
PCT/TR2016/050171 2016-06-08 2016-06-08 Procédé de purification de lait maternel et dispositif pour sa mise en œuvre WO2017213597A1 (fr)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109126887A (zh) * 2018-09-10 2019-01-04 湖南科技大学 一种聚氨酯基复合光催化膜的制备方法
WO2019126308A1 (fr) * 2017-12-19 2019-06-27 Stc.Unm Inhibiteurs de lipase pour la prévention de la rancidité dans le lait maternel exprimé pendant le stockage
CN110835458A (zh) * 2019-11-15 2020-02-25 湖南绿斯达生物科技有限公司 一种具有抑菌效果和高强度的生物降解材料及其制备和应用
CN110975834A (zh) * 2019-12-19 2020-04-10 浙江工业大学 一种超轻可漂浮性材料及其制备方法和应用
US11771769B2 (en) 2017-11-10 2023-10-03 Cocoon Biotech Inc. Ocular applications of silk-based products

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CN109126887A (zh) * 2018-09-10 2019-01-04 湖南科技大学 一种聚氨酯基复合光催化膜的制备方法
CN110835458A (zh) * 2019-11-15 2020-02-25 湖南绿斯达生物科技有限公司 一种具有抑菌效果和高强度的生物降解材料及其制备和应用
CN110835458B (zh) * 2019-11-15 2021-12-24 湖南绿斯达生物科技有限公司 一种具有抑菌效果和高强度的生物降解材料及其制备和应用
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CN110975834B (zh) * 2019-12-19 2022-03-25 浙江工业大学 一种超轻可漂浮性材料及其制备方法和应用

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