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WO2017035176A8 - Method of preventing or treating obesity with an emc10 inhibitor - Google Patents

Method of preventing or treating obesity with an emc10 inhibitor Download PDF

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Publication number
WO2017035176A8
WO2017035176A8 PCT/US2016/048271 US2016048271W WO2017035176A8 WO 2017035176 A8 WO2017035176 A8 WO 2017035176A8 US 2016048271 W US2016048271 W US 2016048271W WO 2017035176 A8 WO2017035176 A8 WO 2017035176A8
Authority
WO
WIPO (PCT)
Prior art keywords
emc10
preventing
inhibitor
treating obesity
obesity
Prior art date
Application number
PCT/US2016/048271
Other languages
French (fr)
Other versions
WO2017035176A1 (en
Inventor
Chong Wee LIEW
Xuanchun WANG
Original Assignee
The Board Of Trustees Of The University Of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees Of The University Of Illinois filed Critical The Board Of Trustees Of The University Of Illinois
Publication of WO2017035176A1 publication Critical patent/WO2017035176A1/en
Publication of WO2017035176A8 publication Critical patent/WO2017035176A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compositions and methods for inhibiting Emc10 expressing or activity and preventing, treating, or delaying the onset of metabolic diseases such obesity are described.
PCT/US2016/048271 2015-08-24 2016-08-24 Method of preventing or treating obesity with an emc10 inhibitor WO2017035176A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562209108P 2015-08-24 2015-08-24
US62/209,108 2015-08-24

Publications (2)

Publication Number Publication Date
WO2017035176A1 WO2017035176A1 (en) 2017-03-02
WO2017035176A8 true WO2017035176A8 (en) 2017-05-04

Family

ID=56889209

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/048271 WO2017035176A1 (en) 2015-08-24 2016-08-24 Method of preventing or treating obesity with an emc10 inhibitor

Country Status (1)

Country Link
WO (1) WO2017035176A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107998397B (en) * 2017-12-07 2020-09-04 复旦大学附属华山医院 Application of EMC10 protein as a biomarker in the diagnosis of male infertility
CN108845142A (en) * 2018-06-19 2018-11-20 上海伦泽生物科技有限公司 Application of the EMC10 Protein Detection object in the diagnosis of preparation obesity and scale evaluation and Bariatric effect assessment product
WO2022048577A1 (en) * 2020-09-07 2022-03-10 复旦大学附属华山医院 Use of monoclonal antibody against human emc10 in preparation of products for preventing and/or treating metabolic diseases
CN114149499B (en) * 2020-09-07 2023-12-05 复旦大学附属华山医院 Monoclonal antibodies against human EMC10 and their use in the treatment and/or prevention of obesity
CN114149500B (en) * 2020-09-07 2023-12-01 复旦大学附属华山医院 Application of monoclonal antibodies against human EMC10 in the preparation of products for treating and/or preventing fatty liver disease
CN114149498B (en) * 2020-09-07 2023-12-05 复旦大学附属华山医院 Application of monoclonal antibody against human EMC10 in preventing and treating type 2 diabetes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101985475A (en) * 2009-07-28 2011-03-16 复旦大学附属华山医院 Novel polyclonal antibody of secretive peptide INM02 and preparation method and use thereof
WO2013003801A2 (en) * 2011-06-29 2013-01-03 The Trustees Of Columbia University In The City Of New York Inhibitor of neuronal connectivity linked to schizophrenia susceptibility and cognitive dysfunction

Also Published As

Publication number Publication date
WO2017035176A1 (en) 2017-03-02

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