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WO2017010953A1 - Pistolet d'application de colle chirurgicale - Google Patents

Pistolet d'application de colle chirurgicale Download PDF

Info

Publication number
WO2017010953A1
WO2017010953A1 PCT/TR2015/050037 TR2015050037W WO2017010953A1 WO 2017010953 A1 WO2017010953 A1 WO 2017010953A1 TR 2015050037 W TR2015050037 W TR 2015050037W WO 2017010953 A1 WO2017010953 A1 WO 2017010953A1
Authority
WO
WIPO (PCT)
Prior art keywords
catheter
glue application
application gun
surgical glue
pulled
Prior art date
Application number
PCT/TR2015/050037
Other languages
English (en)
Inventor
Rasit DINC
Original Assignee
Dinc Rasit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dinc Rasit filed Critical Dinc Rasit
Priority to PCT/TR2015/050037 priority Critical patent/WO2017010953A1/fr
Publication of WO2017010953A1 publication Critical patent/WO2017010953A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00008—Vein tendon strippers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected

Definitions

  • the present invention is related to a medical device and a medical process.
  • I t is particularly related to a procedure and vehicle that is used in preventing varicose veins, preventing the progress of varicose veins, to close aneurysms, to block arteries, to provide a method for said treatments and to treat the related vein malformation.
  • the catheter that is to be used during application does not go into reaction with cyanoacrylate, that the application is not disrupted, that the catheter is not blocked and that the catheter dos not stick to the vein lumen.
  • the most efficient tool to use is the PTFE catheter.
  • PTFE generally is used in order to cover hydrophilic surfaces.
  • the most important characteristic of PTFE is that it does not react with chemicals and it is not affected by high temperatures. Cyanoacrylate transferred into the vein goes into exothermic reaction with the vein and a certain amount of heat is manifested and polymerization starts. During this time, it is a critical factor that while the vein lumen reciprocally sticks to each other the remaining catheter between does not adhere. For this reason the PTFE catheter whose characteristics we have defined need to be produced from pure FTFE raw material.
  • Methyl and ethyl groups show fast effects, and when they become rigid they are highly resistant but they are brittle and less elastic. They are preferred for fast results in surgical applications, and for their resistance when used in hard tissue such as bones.
  • Cyanoacrylates that comprise the butyl and octyl groups that form the subject of the invention show slower effects however when they become hard they still show elasticity features. At the same time they have inflammation effects on the endothelium . Especially in applications related to veins results that make them more preferable are obtained.
  • Figure 1 Example of glue application by following catheter with pressure apply
  • FIG. 2 Gun with Adaptor : Right side view Figure 3: Gun with Adaptor : Left side view Figure 4: Gun without adapter Figure 5: Adaptor : Side view Figure 6: Adaptor : Front view
  • the glue subject to the invention is used to prevent the formation of varicose veins/ to stop it from progressing, to treat varicose veins and to seal vena saphena magna.
  • Butyl based cyanoacrylic (N-Butyl-2-Cyanoacrylate) groups show more elasticity characteristics and as a result they are preferred in such applications.
  • Dimethyl sulfoxide (DMSO) is used as solvent for the cyanoacrylates to adjust the viscosity. DMSO is preferred because of its biocompatibility.
  • Octyl-2-cyanoacrylate comprising and octyl group is used as it is elastic such that it fills the aneurysm (By taking Table 2 as reference) when treating aneurysms with glues that can occur in cerebral veins.
  • cyanoacrylate is also used in the following applications:
  • I n order to stop hemorrhaging and to repair the lesions or to stick parenchyma tissue in hemorrhagic lesions of the liver, kidneys, pancreas and the spleen
  • I n order to seal and strengthen vascular sutures during lung transplantations.
  • I n order to treat seromas occurring after lymph node, and lateral neck and collarbone lymphorrhagia
  • Ethyl-2-Cyanoacrylate is preferred due to fast results in such applications.
  • Methyl cyanoacrylate is preferred as it is resistant and shows fast results.
  • Octyl- 2- Cyanoacrylate is preferred due to elasticity.
  • Octyl-2-Cyanoacrylate is preferred due to elasticity.
  • I n order to endoscopically treat the esophagus, esophagotrachial, gastric, gastro intestinal, duodenal and pancreatic fistulas
  • I n order to endoscopically treat gastric, duodenal and peptic ulcers
  • N-Butyl-2-Cyanoacrylate group is preferred due to its fast effects and elasticity.
  • N-Butyl-2-Cyanoacrylate is preferred as it has fast effects and shows elasticity in arterial and venous embolization.
  • the system features are based on the same principle. According to application the delivery catheter and the introducer sheath lengths and diameters change although the material they are formed of does not change. The selection of materials to be used during procedures is important as it should not react to the cyanoacrylic agent. At the same time these agents also need to be complaint for sterilization.
  • I ntroducer Sheath is not important if the introducer sheath is reactive to the cyanoacrylic agent or not as it does not have contact with said agent. However it is important that it is compliant with blood and the fact that it can be moved forward as it will be used inside the vein lumen.
  • Polyethylene raw material has been used to achieve this.
  • the most suitable density in terms of rigidity has been found.
  • Connector parts have been attached to the ends of the produced sheaths so that they can be attached suitably to the other system parts. Finally in order to provide practical usage, each cm on the sheath has been marked.
  • Polymer container I s a system that shall store the cyanoacrylic agent. I t is important that it does not show reaction to the cyanoacrylic agent. At the same time it should allow EO sterilization and should protect the cyanoacrylic polymer from reaction. For this reason container produced from HDPE have been preferred. LDPE and PU and PA materials have been tried but the results were not healthy.
  • Purpose of this new model is delivering agent inside of the vein lumen with fixed amount of dosage while pulling back the delivery catheter inside of the vessel lumen simultaneously.
  • a PTFE (polytetrafluoroethylene) delivery catheter with application gun that will deliver decided dose of cyanoacrylate according to the vessel diameter to the vessel lumen and specialty of system is the continuous application of cyanoacrylate while pulling the trigger and pulling back the delivery catheter continuously and simultaneously.
  • Adaptor is the part that connects syringe to the gun.
  • I t is adaptable to the all universal injectors.
  • I t has special spin-lock mechanism.
  • the other application of the device with the glue injection and catheter pullback mechanism is continuous pressure applied over the vein by hand or ultrasound probe over the vessel following catheter pullback cycle.
  • This technique provides lower complication rates and higher vessel closure rates while giving minimum foreign material injection inside of the body. Additionally patient comfort and life score is increasing.
  • Another advantage of the invention is closure of the vessel is looks like a string. I n this kind of other closure techniques, vessel lumen is thrombosed and looks like a circle filled inside under the ultrasound. This thrombus inside of the vein starts a thrombosis mechanism and closes the vein in the long term. With this invention vessel closure provides instantly and thrombosis mechanism is cancelled and / or decreased to minimum. Thus vessel closure is gained by endothelium damage without thrombosis function instantly.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un dispositif médical et son application. Elle concerne en particulier un procédé, un dispositif et une procédure visant à empêcher la formation de varices, à stopper la progression des varices, à traiter les varices, à fermer les anévrismes, et à oblitérer les artères.
PCT/TR2015/050037 2015-07-15 2015-07-15 Pistolet d'application de colle chirurgicale WO2017010953A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/TR2015/050037 WO2017010953A1 (fr) 2015-07-15 2015-07-15 Pistolet d'application de colle chirurgicale

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/TR2015/050037 WO2017010953A1 (fr) 2015-07-15 2015-07-15 Pistolet d'application de colle chirurgicale

Publications (1)

Publication Number Publication Date
WO2017010953A1 true WO2017010953A1 (fr) 2017-01-19

Family

ID=54072935

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2015/050037 WO2017010953A1 (fr) 2015-07-15 2015-07-15 Pistolet d'application de colle chirurgicale

Country Status (1)

Country Link
WO (1) WO2017010953A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019086815A1 (fr) 2017-11-06 2019-05-09 Safran Pièce composite à circuit électronique d'instrumentation intégré et son procédé de fabrication
WO2019186465A1 (fr) 2018-03-29 2019-10-03 Primequal Sa Embout et dispositif d'application et d'etalement d'un produit de type liquide, gel ou pate
CN110680416A (zh) * 2019-10-25 2020-01-14 苏州特普新智能科技有限公司 一种下肢静脉曲张封闭机构及封闭方法
CN112294492A (zh) * 2020-10-30 2021-02-02 北京福爱乐科技发展有限公司 一种基于医用胶的疝外科补片的固定方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010096717A1 (fr) * 2009-02-20 2010-08-26 Sapheon, Inc. Procédés et dispositifs pour une occlusion veineuse pour le traitement d'une insuffisance veineuse
WO2013013080A1 (fr) * 2011-07-20 2013-01-24 Sapheon, Inc. Visualisation échographique améliorée de dispositifs intravasculaires
WO2015122859A1 (fr) * 2014-02-14 2015-08-20 Fg Grup Saglik Insaat Harita Mimarlik Muhendislik Elektronik Sanayi Ve Ticaret Ltd. Sti. Système utilisé pour le traitement des veines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010096717A1 (fr) * 2009-02-20 2010-08-26 Sapheon, Inc. Procédés et dispositifs pour une occlusion veineuse pour le traitement d'une insuffisance veineuse
WO2013013080A1 (fr) * 2011-07-20 2013-01-24 Sapheon, Inc. Visualisation échographique améliorée de dispositifs intravasculaires
WO2015122859A1 (fr) * 2014-02-14 2015-08-20 Fg Grup Saglik Insaat Harita Mimarlik Muhendislik Elektronik Sanayi Ve Ticaret Ltd. Sti. Système utilisé pour le traitement des veines

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Biolas Health Inc", 25 March 2015 (2015-03-25), XP055259774, Retrieved from the Internet <URL:http://www.biolas.net/products/details/38/50/156/variclose> [retrieved on 20160318] *
BIOLAS: "Biolas Variclose", YOUTUBE, 25 March 2015 (2015-03-25), pages 1 - 1, XP054976434, Retrieved from the Internet <URL:https://www.youtube.com/watch?v=IQ_g_gyMNQI> [retrieved on 20160322] *
JOSE I. ALMEDIA ET AL: "First human use of cyanoacrylate adhesive for treatment of saphenous vein incompetence - Journal of Vascular Surgery: Venous and Lymphatic Disorders", TWENTY -F OURTH ANNUAL MEETING OF THE AMERICAN VENOUS FORUM, ORLANDO, 11 February 2012 (2012-02-11), pages 1 - 2, XP055263380, Retrieved from the Internet <URL:http://www.jvsvenous.org/article/S2213-333X(12)00030-3/abstract> [retrieved on 20160406], DOI: http://dx.doi.org/10.1016/j.jv sv.2012.09.010 *
ROBERT J. ROSEN ET AL: "Interventional Radiology on Embolization: The Use of Cyanoacrylate Adhesives in the Management of Congenital Vascular Malformations", SEMINAR INTERVENTIONAL RADIOLOGY 2004 MARCH, 31 March 2004 (2004-03-31), pages 1 - 9, XP055263366, Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036205/> [retrieved on 20160406], DOI: 10.1055/s-2004-831406 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019086815A1 (fr) 2017-11-06 2019-05-09 Safran Pièce composite à circuit électronique d'instrumentation intégré et son procédé de fabrication
WO2019186465A1 (fr) 2018-03-29 2019-10-03 Primequal Sa Embout et dispositif d'application et d'etalement d'un produit de type liquide, gel ou pate
US12127738B2 (en) 2018-03-29 2024-10-29 Primequal Sa Tip and device for applying and spreading a liquid, gel or paste product
CN110680416A (zh) * 2019-10-25 2020-01-14 苏州特普新智能科技有限公司 一种下肢静脉曲张封闭机构及封闭方法
CN110680416B (zh) * 2019-10-25 2024-05-10 天琴特普新医疗科技(苏州)有限公司 一种下肢静脉曲张封闭机构及封闭方法
CN112294492A (zh) * 2020-10-30 2021-02-02 北京福爱乐科技发展有限公司 一种基于医用胶的疝外科补片的固定方法

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