WO2017066887A1 - Dispositif d'administration d'un principe actif et procédé d'utilisation de ce dispositif - Google Patents
Dispositif d'administration d'un principe actif et procédé d'utilisation de ce dispositif Download PDFInfo
- Publication number
- WO2017066887A1 WO2017066887A1 PCT/CH2016/000131 CH2016000131W WO2017066887A1 WO 2017066887 A1 WO2017066887 A1 WO 2017066887A1 CH 2016000131 W CH2016000131 W CH 2016000131W WO 2017066887 A1 WO2017066887 A1 WO 2017066887A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chamber
- piston rod
- plug
- carpule
- housing
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title claims abstract description 38
- 238000000034 method Methods 0.000 title claims abstract description 27
- 238000002156 mixing Methods 0.000 claims abstract description 54
- 239000007787 solid Substances 0.000 claims abstract description 13
- 238000006073 displacement reaction Methods 0.000 claims abstract description 7
- 239000002904 solvent Substances 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 23
- 230000037452 priming Effects 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 8
- 230000013011 mating Effects 0.000 claims description 2
- 230000000903 blocking effect Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 7
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 7
- 239000003114 blood coagulation factor Substances 0.000 description 7
- 238000001802 infusion Methods 0.000 description 7
- 208000009292 Hemophilia A Diseases 0.000 description 5
- 210000003462 vein Anatomy 0.000 description 5
- 208000031220 Hemophilia Diseases 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 102100022641 Coagulation factor IX Human genes 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 102100026735 Coagulation factor VIII Human genes 0.000 description 1
- 108010076282 Factor IX Proteins 0.000 description 1
- 108010054218 Factor VIII Proteins 0.000 description 1
- 102000001690 Factor VIII Human genes 0.000 description 1
- 201000003542 Factor VIII deficiency Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000028782 Hereditary disease Diseases 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 208000024556 Mendelian disease Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940105774 coagulation factor ix Drugs 0.000 description 1
- 229940105778 coagulation factor viii Drugs 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 208000009429 hemophilia B Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3148—Means for causing or aiding aspiration or plunger retraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
- A61M2005/2451—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing preventing delivery before mixing is completed, e.g. by locking mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2485—Ampoule holder connected to rest of syringe
- A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
Definitions
- Such a device serves to ensure that a liquid-unstable solid active substance can be mixed with a dissolving liquid only shortly before administration and is thus storable.
- Such devices for example from WO2008 / 122132 A1 and WO2008 / 122360 A2, are known from the prior art.
- a Schnapparm or latching arm may be provided on the Mehrcrokarpulenhalter which can abut against a stop surface or recess or latching groove on the housing in order to limit a relative axial movement between the Mehrhunt- carpule holder and the housing.
- the stop contact between the Schnapparm or latching arm and the stop surface or recess or latching groove may be formed as a radial stop contact
- the Schnapparm or latching arm may be arranged on the circumference of the multi-chamber carpule holder.
- the snap arm or latch arm may extend along a circumferential direction and be radially biased radially, in particular elastically.
- the housing may have the snap arm or latching arm and the multi-chamber carpule holder the stop surface or recess or Rastriile.
- the housing may have the snap arm or latching arm and the multi-chamber carpule holder the stop surface or recess or Rastriile.
- several Schnapparme, latching arms, stop surfaces, recesses or Rastrilien can be provided in each case.
- Figure 1e is a longitudinal sectional view of the first embodiment of the administering device in an aspiration stop position
- FIG. 1e shows a longitudinal sectional view of the first embodiment of the administering device in an aspiration stop position.
- the administering device comprises a first latching device (not shown) which is designed so that after completion of the blending operation an axial displacement of a distal end of the second plug (5) relative to the wall (7) of the multi-chamber carpule (3) via a distal end of the bypass (6) is blocked in the proximal direction. This position defines the aspiration stop position.
- the first latching device can, for example, by a latching arm (not shown) on the piston rod
- the latching may preferably generate an audible signal which may indicate the achievement of a corresponding position.
- the latching arm is designed in such a way that, due to its prestressing and shaping, it blocks, for example as a pawl or hook, rewinding or reversing of the multichamber carput holder (1) relative to the housing (10) by a stop on the latching groove or recess It is therefore only possible to move the multi-chamber coil holder (1) further in the proximal direction It is basically possible to arrange the first detent groove over the length of the housing (10) in such a way that after each revolution of the multi-chamber coiled rod holder (1) From the delivery position, the multi-chamber carpule holder (1) is further locked in the proximal direction until, for example, it locks in a further latching groove with the latching arm, whereby the termination of mixing and / or priming and / or emptying the multi-chamber carpule (3) can be displayed Alternatively or in addition to the audible indication,
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
L'invention concerne un dispositif d'administration d'un principe actif comprenant : une carpule multichambre (3) qui présente une dérivation (6) ménagée dans une paroi (7) de la carpule multichambre (3), et qui comprend au moins une première chambre (8) contenant un principe actif solide et une seconde chambre (9) contenant un liquide de dissolution destiné au principe actif, la seconde chambre (9) étant délimitée par un premier bouchon (4) agencé distalement dans la carpule multichambre (3) et par un second bouchon (5) agencé proximalement dans la carpule multichambre (3) ; un dispositif mélangeur comprenant une tige de piston (2), qui permet de mélanger le principe actif et le liquide de dissolution, dans une position initiale du processus de mélange, le second bouchon (5) étant accouplé à la tige de piston (2) de manière à pouvoir se déplacer en va-et-vient ; un support de carpule (1 ) pour recevoir la carpule multichambre (3) ; et un premier dispositif d'encliquetage qui est situé sur le dispositif d'administration de manière à bloquer, par l'intermédiaire d'une extrémité distale de la dérivation (6), un déplacement axial d'une extrémité distale du second bouchon (5) par rapport à la paroi (7) de la carpule multichambre (3) dans la direction proximale, après l'achèvement du processus de mélange.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH01510/15 | 2015-10-19 | ||
| CH01510/15A CH711657A2 (de) | 2015-10-19 | 2015-10-19 | Vorrichtung zur Verabreichung eines Wirkstoffs und Verfahren zur Bedienung dieser Vorrichtung. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2017066887A1 true WO2017066887A1 (fr) | 2017-04-27 |
Family
ID=57137770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CH2016/000131 WO2017066887A1 (fr) | 2015-10-19 | 2016-10-04 | Dispositif d'administration d'un principe actif et procédé d'utilisation de ce dispositif |
Country Status (2)
| Country | Link |
|---|---|
| CH (1) | CH711657A2 (fr) |
| WO (1) | WO2017066887A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023505560A (ja) * | 2019-12-11 | 2023-02-09 | サノフイ | 注射デバイス |
| CN117462795B (zh) * | 2023-12-26 | 2024-03-08 | 四川省医学科学院·四川省人民医院 | 一种胰岛素笔 |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5080649A (en) * | 1990-02-07 | 1992-01-14 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Dual-compartment hypodermic syringe |
| DE19912322A1 (de) * | 1999-03-19 | 2000-09-28 | Vetter & Co Apotheker | Spritze für medizinische Zwecke |
| EP0721358B1 (fr) | 1993-09-27 | 2002-05-08 | Novo Nordisk A/S | Systeme de circulation pour la perfusion regulee d'un liquide |
| US20030036724A1 (en) * | 2001-08-18 | 2003-02-20 | Vetter Udo J. | Mixing hypodermic syringe |
| WO2007020240A1 (fr) * | 2005-08-13 | 2007-02-22 | Boehringer Ingelheim International Gmbh | Recipient a deux chambres pour la lyophilisation, et procede de remplissage et d'utilisation dudit recipient |
| WO2008122132A1 (fr) | 2007-04-05 | 2008-10-16 | Tecpharma Licensing Ag | Dispositif d'administration à élément d'entraînement fonctionnel |
| WO2008122360A2 (fr) | 2007-04-05 | 2008-10-16 | Tecpharma Licensing Ag | Dispositif d'administration d'une principe actif fluide depuis une ampoule multicavité |
| WO2013048877A1 (fr) | 2011-09-30 | 2013-04-04 | Becton Dickinson France S.A.S. | Seringue avec tige de piston à partie souple |
| CH705991A2 (de) * | 2012-11-29 | 2013-06-14 | Tecpharma Licensing Ag | Mehrkammer-Karpule, insbesondere eine 2-Kammer-Karpule für ein Injektionsgerät. |
| WO2013149032A1 (fr) | 2012-03-29 | 2013-10-03 | Biogen Idec Ma Inc. | Dispositif d'administration et ses composants |
-
2015
- 2015-10-19 CH CH01510/15A patent/CH711657A2/de not_active Application Discontinuation
-
2016
- 2016-10-04 WO PCT/CH2016/000131 patent/WO2017066887A1/fr active Application Filing
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5080649A (en) * | 1990-02-07 | 1992-01-14 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Dual-compartment hypodermic syringe |
| EP0721358B1 (fr) | 1993-09-27 | 2002-05-08 | Novo Nordisk A/S | Systeme de circulation pour la perfusion regulee d'un liquide |
| DE19912322A1 (de) * | 1999-03-19 | 2000-09-28 | Vetter & Co Apotheker | Spritze für medizinische Zwecke |
| US20030036724A1 (en) * | 2001-08-18 | 2003-02-20 | Vetter Udo J. | Mixing hypodermic syringe |
| WO2007020240A1 (fr) * | 2005-08-13 | 2007-02-22 | Boehringer Ingelheim International Gmbh | Recipient a deux chambres pour la lyophilisation, et procede de remplissage et d'utilisation dudit recipient |
| WO2008122132A1 (fr) | 2007-04-05 | 2008-10-16 | Tecpharma Licensing Ag | Dispositif d'administration à élément d'entraînement fonctionnel |
| WO2008122360A2 (fr) | 2007-04-05 | 2008-10-16 | Tecpharma Licensing Ag | Dispositif d'administration d'une principe actif fluide depuis une ampoule multicavité |
| WO2013048877A1 (fr) | 2011-09-30 | 2013-04-04 | Becton Dickinson France S.A.S. | Seringue avec tige de piston à partie souple |
| WO2013149032A1 (fr) | 2012-03-29 | 2013-10-03 | Biogen Idec Ma Inc. | Dispositif d'administration et ses composants |
| CH705991A2 (de) * | 2012-11-29 | 2013-06-14 | Tecpharma Licensing Ag | Mehrkammer-Karpule, insbesondere eine 2-Kammer-Karpule für ein Injektionsgerät. |
Also Published As
| Publication number | Publication date |
|---|---|
| CH711657A2 (de) | 2017-04-28 |
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