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WO2017066887A1 - Dispositif d'administration d'un principe actif et procédé d'utilisation de ce dispositif - Google Patents

Dispositif d'administration d'un principe actif et procédé d'utilisation de ce dispositif Download PDF

Info

Publication number
WO2017066887A1
WO2017066887A1 PCT/CH2016/000131 CH2016000131W WO2017066887A1 WO 2017066887 A1 WO2017066887 A1 WO 2017066887A1 CH 2016000131 W CH2016000131 W CH 2016000131W WO 2017066887 A1 WO2017066887 A1 WO 2017066887A1
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
piston rod
plug
carpule
housing
Prior art date
Application number
PCT/CH2016/000131
Other languages
German (de)
English (en)
Inventor
Susanne Schenker
Urisna STREIT
Original Assignee
Tecpharma Licensing Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecpharma Licensing Ag filed Critical Tecpharma Licensing Ag
Publication of WO2017066887A1 publication Critical patent/WO2017066887A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3148—Means for causing or aiding aspiration or plunger retraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/2451—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing preventing delivery before mixing is completed, e.g. by locking mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet

Definitions

  • Such a device serves to ensure that a liquid-unstable solid active substance can be mixed with a dissolving liquid only shortly before administration and is thus storable.
  • Such devices for example from WO2008 / 122132 A1 and WO2008 / 122360 A2, are known from the prior art.
  • a Schnapparm or latching arm may be provided on the Mehrcrokarpulenhalter which can abut against a stop surface or recess or latching groove on the housing in order to limit a relative axial movement between the Mehrhunt- carpule holder and the housing.
  • the stop contact between the Schnapparm or latching arm and the stop surface or recess or latching groove may be formed as a radial stop contact
  • the Schnapparm or latching arm may be arranged on the circumference of the multi-chamber carpule holder.
  • the snap arm or latch arm may extend along a circumferential direction and be radially biased radially, in particular elastically.
  • the housing may have the snap arm or latching arm and the multi-chamber carpule holder the stop surface or recess or Rastriile.
  • the housing may have the snap arm or latching arm and the multi-chamber carpule holder the stop surface or recess or Rastriile.
  • several Schnapparme, latching arms, stop surfaces, recesses or Rastrilien can be provided in each case.
  • Figure 1e is a longitudinal sectional view of the first embodiment of the administering device in an aspiration stop position
  • FIG. 1e shows a longitudinal sectional view of the first embodiment of the administering device in an aspiration stop position.
  • the administering device comprises a first latching device (not shown) which is designed so that after completion of the blending operation an axial displacement of a distal end of the second plug (5) relative to the wall (7) of the multi-chamber carpule (3) via a distal end of the bypass (6) is blocked in the proximal direction. This position defines the aspiration stop position.
  • the first latching device can, for example, by a latching arm (not shown) on the piston rod
  • the latching may preferably generate an audible signal which may indicate the achievement of a corresponding position.
  • the latching arm is designed in such a way that, due to its prestressing and shaping, it blocks, for example as a pawl or hook, rewinding or reversing of the multichamber carput holder (1) relative to the housing (10) by a stop on the latching groove or recess It is therefore only possible to move the multi-chamber coil holder (1) further in the proximal direction It is basically possible to arrange the first detent groove over the length of the housing (10) in such a way that after each revolution of the multi-chamber coiled rod holder (1) From the delivery position, the multi-chamber carpule holder (1) is further locked in the proximal direction until, for example, it locks in a further latching groove with the latching arm, whereby the termination of mixing and / or priming and / or emptying the multi-chamber carpule (3) can be displayed Alternatively or in addition to the audible indication,

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif d'administration d'un principe actif comprenant : une carpule multichambre (3) qui présente une dérivation (6) ménagée dans une paroi (7) de la carpule multichambre (3), et qui comprend au moins une première chambre (8) contenant un principe actif solide et une seconde chambre (9) contenant un liquide de dissolution destiné au principe actif, la seconde chambre (9) étant délimitée par un premier bouchon (4) agencé distalement dans la carpule multichambre (3) et par un second bouchon (5) agencé proximalement dans la carpule multichambre (3) ; un dispositif mélangeur comprenant une tige de piston (2), qui permet de mélanger le principe actif et le liquide de dissolution, dans une position initiale du processus de mélange, le second bouchon (5) étant accouplé à la tige de piston (2) de manière à pouvoir se déplacer en va-et-vient ; un support de carpule (1 ) pour recevoir la carpule multichambre (3) ; et un premier dispositif d'encliquetage qui est situé sur le dispositif d'administration de manière à bloquer, par l'intermédiaire d'une extrémité distale de la dérivation (6), un déplacement axial d'une extrémité distale du second bouchon (5) par rapport à la paroi (7) de la carpule multichambre (3) dans la direction proximale, après l'achèvement du processus de mélange.
PCT/CH2016/000131 2015-10-19 2016-10-04 Dispositif d'administration d'un principe actif et procédé d'utilisation de ce dispositif WO2017066887A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH01510/15A CH711657A2 (de) 2015-10-19 2015-10-19 Vorrichtung zur Verabreichung eines Wirkstoffs und Verfahren zur Bedienung dieser Vorrichtung.
CH01510/15 2015-10-19

Publications (1)

Publication Number Publication Date
WO2017066887A1 true WO2017066887A1 (fr) 2017-04-27

Family

ID=57137770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH2016/000131 WO2017066887A1 (fr) 2015-10-19 2016-10-04 Dispositif d'administration d'un principe actif et procédé d'utilisation de ce dispositif

Country Status (2)

Country Link
CH (1) CH711657A2 (fr)
WO (1) WO2017066887A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230001091A1 (en) * 2019-12-11 2023-01-05 Sanofi Injection device
CN117462795B (zh) * 2023-12-26 2024-03-08 四川省医学科学院·四川省人民医院 一种胰岛素笔

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5080649A (en) * 1990-02-07 1992-01-14 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Dual-compartment hypodermic syringe
DE19912322A1 (de) * 1999-03-19 2000-09-28 Vetter & Co Apotheker Spritze für medizinische Zwecke
EP0721358B1 (fr) 1993-09-27 2002-05-08 Novo Nordisk A/S Systeme de circulation pour la perfusion regulee d'un liquide
US20030036724A1 (en) * 2001-08-18 2003-02-20 Vetter Udo J. Mixing hypodermic syringe
WO2007020240A1 (fr) * 2005-08-13 2007-02-22 Boehringer Ingelheim International Gmbh Recipient a deux chambres pour la lyophilisation, et procede de remplissage et d'utilisation dudit recipient
WO2008122360A2 (fr) 2007-04-05 2008-10-16 Tecpharma Licensing Ag Dispositif d'administration d'une principe actif fluide depuis une ampoule multicavité
WO2008122132A1 (fr) 2007-04-05 2008-10-16 Tecpharma Licensing Ag Dispositif d'administration à élément d'entraînement fonctionnel
WO2013048877A1 (fr) 2011-09-30 2013-04-04 Becton Dickinson France S.A.S. Seringue avec tige de piston à partie souple
CH705991A2 (de) * 2012-11-29 2013-06-14 Tecpharma Licensing Ag Mehrkammer-Karpule, insbesondere eine 2-Kammer-Karpule für ein Injektionsgerät.
WO2013149032A1 (fr) 2012-03-29 2013-10-03 Biogen Idec Ma Inc. Dispositif d'administration et ses composants

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5080649A (en) * 1990-02-07 1992-01-14 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Dual-compartment hypodermic syringe
EP0721358B1 (fr) 1993-09-27 2002-05-08 Novo Nordisk A/S Systeme de circulation pour la perfusion regulee d'un liquide
DE19912322A1 (de) * 1999-03-19 2000-09-28 Vetter & Co Apotheker Spritze für medizinische Zwecke
US20030036724A1 (en) * 2001-08-18 2003-02-20 Vetter Udo J. Mixing hypodermic syringe
WO2007020240A1 (fr) * 2005-08-13 2007-02-22 Boehringer Ingelheim International Gmbh Recipient a deux chambres pour la lyophilisation, et procede de remplissage et d'utilisation dudit recipient
WO2008122360A2 (fr) 2007-04-05 2008-10-16 Tecpharma Licensing Ag Dispositif d'administration d'une principe actif fluide depuis une ampoule multicavité
WO2008122132A1 (fr) 2007-04-05 2008-10-16 Tecpharma Licensing Ag Dispositif d'administration à élément d'entraînement fonctionnel
WO2013048877A1 (fr) 2011-09-30 2013-04-04 Becton Dickinson France S.A.S. Seringue avec tige de piston à partie souple
WO2013149032A1 (fr) 2012-03-29 2013-10-03 Biogen Idec Ma Inc. Dispositif d'administration et ses composants
CH705991A2 (de) * 2012-11-29 2013-06-14 Tecpharma Licensing Ag Mehrkammer-Karpule, insbesondere eine 2-Kammer-Karpule für ein Injektionsgerät.

Also Published As

Publication number Publication date
CH711657A2 (de) 2017-04-28

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