WO2016111661A1 - Technique de formulation de capsule pour le pyriproxyfène, un analogue d'hormone juvénile utilisé comme régulateur de croissance d'insectes - Google Patents
Technique de formulation de capsule pour le pyriproxyfène, un analogue d'hormone juvénile utilisé comme régulateur de croissance d'insectes Download PDFInfo
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- WO2016111661A1 WO2016111661A1 PCT/TR2016/000003 TR2016000003W WO2016111661A1 WO 2016111661 A1 WO2016111661 A1 WO 2016111661A1 TR 2016000003 W TR2016000003 W TR 2016000003W WO 2016111661 A1 WO2016111661 A1 WO 2016111661A1
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- Prior art keywords
- formulation according
- reactant
- weight
- pyriproxyfen
- formulation
- Prior art date
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- NHDHVHZZCFYRSB-UHFFFAOYSA-N pyriproxyfen Chemical compound C=1C=CC=NC=1OC(C)COC(C=C1)=CC=C1OC1=CC=CC=C1 NHDHVHZZCFYRSB-UHFFFAOYSA-N 0.000 title claims abstract description 49
- 239000005927 Pyriproxyfen Substances 0.000 title claims abstract description 47
- 238000000034 method Methods 0.000 title claims abstract description 25
- 241000238631 Hexapoda Species 0.000 title claims description 18
- 239000007963 capsule composition Substances 0.000 title description 4
- 239000003630 growth substance Substances 0.000 title description 3
- 239000002950 juvenile hormone derivative Substances 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims abstract description 105
- 238000009472 formulation Methods 0.000 claims abstract description 81
- 241000607479 Yersinia pestis Species 0.000 claims abstract description 28
- 230000009471 action Effects 0.000 claims abstract description 11
- 230000005180 public health Effects 0.000 claims abstract description 8
- 239000000376 reactant Substances 0.000 claims description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- 239000000839 emulsion Substances 0.000 claims description 17
- 239000003995 emulsifying agent Substances 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 15
- 239000002775 capsule Substances 0.000 claims description 13
- 239000007798 antifreeze agent Substances 0.000 claims description 11
- 241000196324 Embryophyta Species 0.000 claims description 10
- 239000002518 antifoaming agent Substances 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 239000003921 oil Substances 0.000 claims description 10
- 235000019198 oils Nutrition 0.000 claims description 10
- 239000002562 thickening agent Substances 0.000 claims description 10
- 229920002396 Polyurea Polymers 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 8
- 150000001412 amines Chemical class 0.000 claims description 8
- 230000000845 anti-microbial effect Effects 0.000 claims description 8
- 239000003755 preservative agent Substances 0.000 claims description 8
- 238000006116 polymerization reaction Methods 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
- 150000001298 alcohols Chemical class 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 239000003054 catalyst Substances 0.000 claims description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 6
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 claims description 6
- -1 ether sulfates Chemical class 0.000 claims description 6
- 230000036541 health Effects 0.000 claims description 6
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 claims description 6
- 230000002035 prolonged effect Effects 0.000 claims description 6
- 239000003981 vehicle Substances 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 5
- 239000013543 active substance Substances 0.000 claims description 5
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 claims description 5
- ZXHZWRZAWJVPIC-UHFFFAOYSA-N 1,2-diisocyanatonaphthalene Chemical compound C1=CC=CC2=C(N=C=O)C(N=C=O)=CC=C21 ZXHZWRZAWJVPIC-UHFFFAOYSA-N 0.000 claims description 4
- UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 claims description 4
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 4
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- 239000005057 Hexamethylene diisocyanate Substances 0.000 claims description 4
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 claims description 4
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- 239000008096 xylene Substances 0.000 claims description 4
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000003090 pesticide formulation Substances 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 230000000284 resting effect Effects 0.000 claims description 3
- VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 claims description 2
- QQGRFMIMXPWKPM-UHFFFAOYSA-N 2,3,4-tributylphenol Chemical compound CCCCC1=CC=C(O)C(CCCC)=C1CCCC QQGRFMIMXPWKPM-UHFFFAOYSA-N 0.000 claims description 2
- IEORSVTYLWZQJQ-UHFFFAOYSA-N 2-(2-nonylphenoxy)ethanol Chemical group CCCCCCCCCC1=CC=CC=C1OCCO IEORSVTYLWZQJQ-UHFFFAOYSA-N 0.000 claims description 2
- 244000215068 Acacia senegal Species 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 2
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 claims description 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 229920000084 Gum arabic Polymers 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- ZXICARZQVZHUKX-UHFFFAOYSA-N N=C=O.C=C1CCCCC1C1CCCCC1 Chemical compound N=C=O.C=C1CCCCC1C1CCCCC1 ZXICARZQVZHUKX-UHFFFAOYSA-N 0.000 claims description 2
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical group OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 150000004996 alkyl benzenes Chemical class 0.000 claims description 2
- 125000000129 anionic group Chemical group 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims description 2
- 229940043279 diisopropylamine Drugs 0.000 claims description 2
- IUNMPGNGSSIWFP-UHFFFAOYSA-N dimethylaminopropylamine Chemical compound CN(C)CCCN IUNMPGNGSSIWFP-UHFFFAOYSA-N 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 230000008014 freezing Effects 0.000 claims description 2
- 238000007710 freezing Methods 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- 150000002334 glycols Chemical class 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 229930195733 hydrocarbon Natural products 0.000 claims description 2
- 150000002430 hydrocarbons Chemical class 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 230000000977 initiatory effect Effects 0.000 claims description 2
- NIMLQBUJDJZYEJ-UHFFFAOYSA-N isophorone diisocyanate Chemical compound CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1 NIMLQBUJDJZYEJ-UHFFFAOYSA-N 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 150000004702 methyl esters Chemical class 0.000 claims description 2
- HAMGRBXTJNITHG-UHFFFAOYSA-N methyl isocyanate Chemical compound CN=C=O HAMGRBXTJNITHG-UHFFFAOYSA-N 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 229920000847 nonoxynol Polymers 0.000 claims description 2
- 150000002894 organic compounds Chemical class 0.000 claims description 2
- 150000003014 phosphoric acid esters Chemical class 0.000 claims description 2
- 238000006068 polycondensation reaction Methods 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 150000003141 primary amines Chemical class 0.000 claims description 2
- 150000003335 secondary amines Chemical class 0.000 claims description 2
- 238000006277 sulfonation reaction Methods 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 150000003505 terpenes Chemical class 0.000 claims description 2
- 235000007586 terpenes Nutrition 0.000 claims description 2
- 150000003512 tertiary amines Chemical group 0.000 claims description 2
- RKBCYCFRFCNLTO-UHFFFAOYSA-N triisopropylamine Chemical compound CC(C)N(C(C)C)C(C)C RKBCYCFRFCNLTO-UHFFFAOYSA-N 0.000 claims description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 235000013311 vegetables Nutrition 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 239000000575 pesticide Substances 0.000 description 14
- 239000004490 capsule suspension Substances 0.000 description 11
- 239000004562 water dispersible granule Substances 0.000 description 11
- 239000000843 powder Substances 0.000 description 7
- 239000008187 granular material Substances 0.000 description 6
- 239000004546 suspension concentrate Substances 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 241000255925 Diptera Species 0.000 description 4
- 241000257159 Musca domestica Species 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 230000009931 harmful effect Effects 0.000 description 3
- 230000000749 insecticidal effect Effects 0.000 description 3
- 239000004530 micro-emulsion Substances 0.000 description 3
- DWFZBUWUXWZWKD-UHFFFAOYSA-N pyridaben Chemical compound C1=CC(C(C)(C)C)=CC=C1CSC1=C(Cl)C(=O)N(C(C)(C)C)N=C1 DWFZBUWUXWZWKD-UHFFFAOYSA-N 0.000 description 3
- 239000004550 soluble concentrate Substances 0.000 description 3
- 239000005660 Abamectin Substances 0.000 description 2
- 238000012695 Interfacial polymerization Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000004491 dispersible concentrate Substances 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000012669 liquid formulation Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 239000004565 water dispersible tablet Substances 0.000 description 2
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- 241001674044 Blattodea Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000244206 Nematoda Species 0.000 description 1
- 241000819999 Nymphes Species 0.000 description 1
- 239000005663 Pyridaben Substances 0.000 description 1
- 229950008167 abamectin Drugs 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000459 effect on growth Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004495 emulsifiable concentrate Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000007944 soluble tablet Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 239000003799 water insoluble solvent Substances 0.000 description 1
- 239000004554 water soluble tablet Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
Definitions
- the invention relates to the manufacture of the capsule formulation of pyriproxyfen molecule for use in the plant protection, the control of mosquito/housefly larvae and the control of insect pests in the veterinary hygiene and to the use thereof for the mentioned purpose.
- prolonged action is obtained and the three (3) generations of the insect pests are taken under control with a single application.
- the invention relates to the action that lasts at least 2-3 times longer than the other previous formulations (EW, EC, WDG, G) owing to the novel capsulation formulation of pyriproxyfen, which is used against the agricultural pests (larvae and nymphs) and the larvae of mosquito and housefly.
- the capsules of pyriproxyfen according to the invention have been observed to be effective also on the insect pest eggs, in addition to the larvae and nymphs.
- the invention also relates to the use of the CS type in the control of the nymphs of flea and cockroach within the context of public health.
- the capsulation manufacturing technique and the superior efficacy obtained with this formula are also within the scope of the invention.
- the liquid formulations include Simple Solutions (Water Soluble Concentrates (SL), Solutions for Use in the Seed Dressing (LS), Liquid Formulations Dissolved in Oil (OL), Ultra Low Volume Liquids (UL), Dispersible Solutions (Emulsifiable Concentrates (EC), Dispersible Concentrates (DC), Emulsions (Emulsions (oil in water) (EW), Emulsions for Use in the Seed Dressing (ES), Micro-emulsions (ME), Suspensions (Aqueous Suspension Concentrates (SC), Suspension Concentrates Applied to Seeds (FS), Suspension Concentrates of Oil Origin (OD), Aqueous Suspo-emulsions (SE) and Dual Character Formulations.
- Simple Solutions Water Soluble Concentrates (SL), Solutions for Use in the Seed Dressing (LS), Liquid Formulations Dissolved in Oil (OL), Ultra Low Volume Liquids (UL), Dispersible Solutions (Emulsifiable Concentrates (EC), Dispersible Concentrates (DC), Emul
- Solid formulations are classified as Directly Used Solid Formulations (Powder preparations (DP), Powders for Dry Application to the Seeds (DS), Granules (GR), Directly Used Tablets (DT), Solid Formulations used after Dispersion in Water (Wettable Powders (WP), Dispersible Powders for Use in the Seed Dressing (WS), Water Dispersible Granules (WG), Water Dispersible Tablets (WT), Emulsifiable Granules (EG), Emulsifiable Powders (EP), Solid Formulations used after Dissolution in Water (Water-Soluble Powders (SP), Water Soluble Powders for use in the Seed Dressing (WS), Water Soluble Granules (SG) and Water Soluble Tablets (ST)).
- DP Directly Used Solid Formulations
- DP Powders for Dry Application to the Seeds
- GS Granules
- Directly Used Tablets Solid Formulations used after Dispersion in Water (WP), Dispersible Powders for Use in the Seed Dressing (WS), Water
- the pesticide manufacturers always search the ways for developing and formulating the pesticides in a way that is safer for the environment, humans and other non-targeted organisms, or they receive the support from the academic institutions in this regard.
- the increasing environmental consciousness and the research conducted about the harmful effects of the chemicals have accelerated these efforts even further.
- the harmful effects of the pesticides on the one hand and the health risks and economic losses caused by the insect pests on the other hand prompted the researches to seek a safer and more effective pesticide.
- the emulsion concentrate (EC) and oil in water emulsion (EW) formulations of pyriproxyfen are used for the protection of plants.
- the formulation types of Emulsion Concentrate (EC), Suspension Concentrate (SC), Granule (Gr) and Water Dispersible Granule (WDG) are used.
- EC Emulsion Concentrate
- SC Suspension Concentrate
- Gr Granule
- WDG Water Dispersible Granule
- SC, EC, WDG, Gr and EW formulation types lead to many undesirable results such as the irritation and the harmful effects of the auxiliary substances.
- Emulsion Concentrate EC
- Oil in Water Formulation Oil in Water Emulsion-EW
- Granule G
- Water Dispersible Granule WG, WDG
- Capsule Suspension CS
- pyriproxyfen pyriproxyfen
- invention no. CN 101379982 B entitled "Insecticidal composition containing pyriproxyfen and avermectin" relates to a composition belonging to the technical field of pesticides and comprising pyriproxyfen and abamectin and synergy.
- the invention no. CN 103385251 A entitled "Insecticidal composition comprising pyriproxyfen” is an insecticidal composition comprising pyriproxyfen.
- Said invention provides synergic effect against various pests that damage the agricultural products. By means of the composition, the pesticide dose is reduced, the pesticide dose on the plants is reduced and the environmental pollution is reduced.
- the object of the invention obtained based on the mentioned state of the art is to enable the formulation of pyriproxyfen molecule, which is used for the control of insect pests in the plant protection, public health (control of mosquito-housefly larvae) and the animal health, by means of the capsulation (CS, MC) technique being safer for the human and other non-targeted organisms, reducing/eliminating the problem of residue in the foods and the crops and providing prolonged action.
- Another object of the invention is to develop a novel formulation technique capable of controlling minimum 3 generations by means of a single application. This provides the possibility of both preventing the contamination of the environment and the products owing to the smaller amount of chemical used and of developing a control program with lower cost.
- Another object of the invention is to achieve the control of the new resistant nymphs, which will hatch after the application of the pesticide, before they reach the mature state, owing to the insect growth regulator (IGR) active agents.
- IGR insect growth regulator
- Another object of the invention is to prevent the labor losses by reducing the number of pesticide applications. Another object of the invention is to obtain a safer formulation with the water-based capsulation instead of the hazardous solvents and other auxiliary substances in the conventional formulations.
- Another object of the invention is to provide a solution for the inability to achieve uninterrupted control between the generations, which is a problem of the prior art. Owing to the long term control provided by the capsulation technique, the uninterrupted control of the insect pests becomes possible.
- Active agent is protected from the sun rays by the polymer shell.
- the pesticide composition is developed, which is described below with all the details and alternative embodiments.
- This composition is used for the control of pests in many fields, notably the agricultural pests.
- the invention provides a capsule formulation of pyriproxyfen molecule for use in the control of insect pests in the plant protection, public health and animal health, comprising pyriproxyfen, emulsifier mixture, solvent, antimicrobial preservative agent, anti-foam agent, anti-freeze agent, reactant 1 , reactant 2, reactant 3, thickener and vehicle, wherein said formulation is safer for the human and other non-targeted organisms, reduces/eliminates the problem of residue in the foods and the crops and provides prolonged action.
- the invention also provides a capsulation (CS, MC) method for said formulation comprising the process steps of mixing pyriproxyfen, solvent and capsule reactant 1 to prepare an emulsifiable pyriproxyfen solution, adding emulsifier mixture, antifreeze agent, antimicrobial preservative agent and anti-foam agent into the water to prepare the water phase of the emulsion, emulsifying the prepared pyriproxyfen solution in the water phase with the aid of a high-speed mixer, slowly adding the other reactants, i.e. reactant 2 and reactant 3, into the emulsion formed, resting the mixture in order to terminate the initiated polymerization reaction and then adjusting the viscosity with the aid of the thickener.
- CS, MC capsulation
- the invention relates to the use of pyriproxyfen with the capsule suspension (CS) formulation type for the control of the pests in the plant protection (pests mentioned in the following table) and the public health (control of the mosquito and housefly larvae).
- CS capsule suspension
- the technique for manufacturing the pesticide composition according to the invention is similar to the capsulation technique applications for the other pesticide molecules.
- the primary feature is the ability to obtain more effective result in the pest control, owing to the capsulation of the pyriproxyfen molecule.
- the capsulation form of pyriproxyfen was never tried in the plant protection, public health and animal health. Table.1. Agricultural Pests:
- the manufacturing technique for the formulation with given contents by percentage comprises the following process steps:
- the emulsifier mixture mentioned in the table may be a combination of more than one emulsifier or may comprise a single emulsifier. These emulsifiers may belong to ionic, anionic and nonionic group or may be a combination of these groups.
- the emulsifiers able to be used in the product include amine ethoxylates, EO/PO block polymers, ether sulfates, saturated alcohol alkoxylates, saturated alcohol ethoxylates, sorbitan ester ethoxylates, tributylphenol ethoxylates, phosphate esters, tristryl phenol ethoxylates, sulfonation products, polycondensation products, nonyl phenol ethoxylates, alkyl benzene sulfonates, castor oil ethoxylates, EO/PO alkoxylation products, saturated alcohol ethoxylates, olein sulfonates and sulfosuccinate groups, which may be used alone or in combinations according to different proportions.
- a 1/1 mixture of tristryl phenol ethoxylate and nonyl phenol ethoxylate groups is preferably used.
- the solvent mentioned in the table is the liquid medium, in which the normally solid active agent pyriproxyfen is dissolved. Since the invention is realized with the interfacial polymerization technique, it may be formulated using only the water- insoluble solvents.
- the hydrocarbons such as xylene, benzene, toluene, cyclohexane, solvesso 100, solvesso 150, solvesso 200 and exxsol series as well as the vegetable oils obtained from oily seeds, their ethyl and methyl esters and the terpenes of vegetable origin are encompassed by the invention.
- a combination of more than one solvent may also be used.
- the xylene solvent is preferably used.
- the anti-freeze agent mentioned in the table comprises the glycol derivatives that prevent the freezing at low temperatures as a known practice in the water-based pesticide formulations. These additives are ethylene glycol, monopropylene glycol, dipropylene glycol, diethylene glycol and glycerin. In the formulation, monopropylene glycol is preferably used.
- the reactant 1 mentioned in the table refers to the organic compounds that contain isocyanate functional group.
- the function of the reactant 1 in the formulation is to polymerize on the emulsion droplets-water interface and form a polyurea capsule wall with the aid of catalyst solution following the formation of emulsion by way of addition thereof into the prepared pyriproxyfen oil phase.
- These compounds may be methyl isocyanate, methylene diphenyl diisocyanate (MDI), hexamethylene diisocyanate (HDI), toluene diisocyanate (TDI), naphthalene diisocyanate (NDI), methylene bicyclohexyl isocyanate (HMDI) or isophorone diisocyanate (IPDI).
- MDI methylene diphenyl diisocyanate
- HDI hexamethylene diisocyanate
- TDI toluene diisocyanate
- NDI naphthalene diisocyanate
- HMDI methylene bicyclohexyl isocyanate
- IPDI isophorone diisocyanate
- Reactant 2 and reactant 3 mentioned in the table are amines that form a polyurea capsule shell by undergoing polymerization reaction with the reactant 1 , i.e. the isocyanate group.
- a premix of reactant 2 and reactant 3 is formed in water to prepare the catalyst solution.
- the prepared catalyst solution is slowly added on the pyriproxyfen oil phase emulsified in water, thereby initiating the reaction for the formation of the polyurea capsule shell.
- Amines used in the synthesis of the polyurea capsule shell may belong to the primary, secondary or tertiary amine groups.
- Said amines include ethylamine, ethylene diamine, diethylene triamine, triethylene tetraamine, dimethylamine, trimethylamine, diethylamine, diisopropylamine, dimethylaminopropylamine and triisopropylamine.
- the thickener mentioned in the table refers to the additives able to be used for adjusting the viscosity of the formulation after the polymerization reaction terminates. These include xanthan gum, guar gum, gum arabic, carboxymethyl cellulose, methyl cellulose, hydroxypropyl cellulose. In the formulation, xanthan gum is preferably used.
- the vehicle mentioned in the table is water and the anti-foam agent and the antimicrobial preservative agent are the products frequently used in the pesticide formulations.
- a silicone-based anti-foam agent is preferably used in the formulation.
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
La présente invention concerne l'action qui dure au moins 2 à 3 fois plus longtemps que les autres formulations précédentes (EW, EC) grâce à la nouvelle formulation d'encapsulation du pyriproxyfène, qui est utilisé contre les parasites agricoles. L'invention concerne également l'utilisation du type CS dans la lutte contre les larves et les nymphes de moustiques, de mouches domestiques, de blattes, dans le contexte de la santé publique. La technique de fabrication d'encapsulation et l'efficacité supérieure obtenue sont dans le cadre de l'invention.
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