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WO2016169798A1 - Utilisation de l'hibifoline contre le vieillissement de la peau - Google Patents

Utilisation de l'hibifoline contre le vieillissement de la peau Download PDF

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Publication number
WO2016169798A1
WO2016169798A1 PCT/EP2016/057888 EP2016057888W WO2016169798A1 WO 2016169798 A1 WO2016169798 A1 WO 2016169798A1 EP 2016057888 W EP2016057888 W EP 2016057888W WO 2016169798 A1 WO2016169798 A1 WO 2016169798A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
cosmetic
hibifolin
aging
weight
Prior art date
Application number
PCT/EP2016/057888
Other languages
German (de)
English (en)
Inventor
Marc Winnefeld
Sabine HAGEMANN
Jörn SÖHLE
Elke GRÖNNIGER
Torsten Schläger
Katrin Schmidt
Ute Breitenbach
Original Assignee
Beiersdorf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf Ag filed Critical Beiersdorf Ag
Publication of WO2016169798A1 publication Critical patent/WO2016169798A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • the present invention relates to cosmetic or dermatological preparations containing active ingredients for the care and protection of the skin, in particular the skin aged or aging by intrinsic and / or extrinsic factors and the use of such active ingredients and combinations of such active ingredients in the field of cosmetic and dermatological skin care ,
  • Cosmetic skincare is primarily understood as strengthening or restoring the skin's natural function as a barrier against environmental influences (e.g., dirt, chemicals, microorganisms) and against the loss of endogenous substances (e.g., water, natural fats, electrolytes).
  • environmental influences e.g., dirt, chemicals, microorganisms
  • endogenous substances e.g., water, natural fats, electrolytes
  • the aim of skin care is also to compensate for the daily loss of fat and water loss of the skin. This is especially important when the natural regeneration capacity is insufficient.
  • skin care products to protect against environmental influences, especially from the sun and wind, and delay the aging of the skin.
  • Exogenous factors such as UV light and chemical noxae, can be cumulatively effective and, for example, accelerate or supplement endogenous aging processes.
  • the following structural and functional disorders in the skin occur, in particular due to exogenous factors, which go beyond the extent and quality of the damage associated with chronological aging: d) Visible vascular dilations (telangiectasias, cuperosis);
  • the present invention relates in particular to products for the care of naturally aged skin, as well as for the treatment of the consequential damages of photoageing, in particular of the phenomena listed under a) to g).
  • Products for the care of aged skin are known per se. They contain e.g. Retinoids (vitamin A acid and / or derivatives thereof) or vitamin A and / or its derivatives. Their effect on the structural damage, however, is limited in scope. In addition, there are significant difficulties in product development in stabilizing the active ingredients sufficiently against oxidative degradation. In addition, the use of vitamin A acid-containing products often causes severe erythematous skin irritation. Retinoids can therefore only be used in low concentrations.
  • the present invention relates to cosmetic preparations with effective protection against harmful oxidation processes in the skin, but also for the protection of cosmetic preparations themselves or for the protection of the components of cosmetic preparations from harmful oxidation processes.
  • the present invention further relates to antioxidants, preferably those which are used in skin-care cosmetic or dermatological preparations.
  • the invention also relates to cosmetic and dermatological preparations containing such antioxidants.
  • the present invention relates to cosmetic and dermatological preparations for the prophylaxis and treatment of cosmetic or dermatological skin changes, such as skin aging, in particular the skin aging caused by oxidative processes.
  • the present invention relates to combinations of active substances and preparations which serve for the prophylaxis and treatment of photosensitive skin, in particular photodermatoses.
  • UVC range rays with a wavelength less than 290 nm
  • UVB range rays in the range between 290 nm and 320 nm, the so-called UVB range, cause erythema simple sunburn or even more or less severe burns.
  • UVA range it is important to have available filter substances, since its rays can cause reactions in photosensitive skin. It has been proven that UVA radiation leads to damage to the elastic and collagenous fibers of the connective tissue, causing the skin to age prematurely, and that it is the cause of numerous phototoxic and photoallergic reactions. The damaging influence of UVB radiation can be amplified by UVA radiation.
  • UV radiation can also lead to photochemical reactions, in which case the photochemical reaction products intervene in the skin metabolism.
  • such photochemical reaction products are free-radical compounds, for example hydroxy radicals.
  • Undefined Radical Photo Due to their high reactivity, products that develop in the skin itself may show uncontrolled sequelae.
  • singlet oxygen a non-radical excited state of the oxygen molecule, can also occur on UV irradiation, as can short-lived epoxides and many others.
  • Singlet oxygen for example, is distinguished from the normally present triplet oxygen (radical ground state) by increased reactivity.
  • there are also excited, reactive (radical) triplet states of the oxygen molecule are also excited.
  • UV radiation counts as ionizing radiation.
  • ionic species may also be formed upon UV exposure, which in turn may oxidatively interfere with the biochemical processes.
  • Mainly antioxidants are used as protective substances against spoilage of preparations containing them. Nevertheless, it is known that undesirable oxidation processes can also occur in human and animal skin. Such processes play an essential role in skin aging.
  • antioxidants and / or radical scavengers may additionally be incorporated into cosmetic or dermatological formulations.
  • antioxidants and radical scavengers are known.
  • vitamin E a substance with known antioxidant activity in sunscreen formulations, but the effect achieved remains far below the hoped-for effect.
  • the object of the present invention was therefore to find ways that avoid the disadvantages of the prior art.
  • the effect of repairing the damage associated with endogenous, chronological and exogenous skin aging and the prophylaxis should be permanent, sustainable and without the risk of side effects. To remedy these evils was the object of the present invention.
  • cosmetic or dermatological preparations containing hibifolin or the use of hibifolin in cosmetic or dermatological preparations for the treatment and prophylaxis of the symptoms of intrinsic and / or extrinsic skin aging and for the treatment and prophylaxis of the harmful effects of ultraviolet radiation on the skin remedies the disadvantages of the prior art.
  • the active ingredient according to the invention or cosmetic or topical dermatological preparations with an effective content of the active ingredient according to the invention also serves in a surprising manner
  • hibifolin or cosmetic or topical dermatological preparations with an effective content of hibifolin for the cosmetic or dermatological treatment or prophylaxis of undesirable skin conditions.
  • the preparations contain 0.0001 to 5 wt .-%, in particular 0.001 to 1 wt .-%, very particularly 0.005 to 0, 15 wt .-% hibifolin, based on the total weight the preparation.
  • topical preparations in particular cosmetic or dermatological preparations.
  • Cosmetic or dermatological preparations according to the invention preferably contain from 0.001 to 10% by weight, particularly preferably 0.01 to 1% by weight, of hibifolin, based on the total composition of the preparations.
  • Emulsions are advantageous dosage forms for the purposes of the present invention, for example in the form of a cream, a lotion, a cosmetic milk are advantageous and included
  • fats, oils, waxes and / or other fatty substances, and water and one or more emulsifiers, such as are commonly used for such a type of formulation are advantageous and included
  • emulsifiers such as are commonly used for such a type of formulation.
  • Medicinal topical compositions according to the present invention usually contain one or more drugs in effective concentration.
  • drugs for the sake of simplicity, reference is made to the clear distinction between cosmetic and medical use and corresponding products to the statutory provisions of the Federal Republic of Germany (for example, Cosmetics Regulation, Food and Medicines Act).
  • the cosmetic or dermatological preparation in the sense of the present invention is a solution or emulsion or dispersion, it is possible to use as solvent:
  • Oils such as triglycerides of capric or caprylic acid, but preferably castor oil; Fats, waxes and other natural and synthetic fats, preferably esters of fatty acids with lower C-number alcohols, e.g. with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low C number or with fatty acids;
  • Alcohols, diols or polyols of low C number, and their ethers preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products ,
  • mixtures of the abovementioned solvents are used.
  • alcoholic solvents water can be another ingredient.
  • the oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions in the context of the present invention is advantageously selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids having a chain length of 3 to 30 carbon atoms and saturated and / or or unsaturated, branched and / or unbranched alcohols having a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of 3 to 30 carbon atoms.
  • ester oils can then advantageously be selected from the group consisting of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2 Hexyldecyl stearate, 2-octyl dodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate and synthetic, semi-synthetic and natural mixtures of such esters, for example jojoba oil.
  • the oil phase can be advantageously selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and the fatty acid triglycerides, in particular the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 8 to 24, in particular 12 to 18 carbon atoms.
  • the fatty acid triglycerides can be advantageously selected from the group of synthetic, semi-synthetic and natural oils, e.g. Olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil, and the like.
  • Alcohols, diols or polyols of low C number, and their ethers preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products , furthermore low C-number alcohols, eg Ethanol, isopropanol, 1, 2-propanediol, glycerol and in particular one or more thickening agents, which or which can be advantageously selected from the group of silica, aluminum silicates, polysaccharides or their derivatives, e.g.
  • Hyaluronic acid, xanthan gum, hydroxypropylmethylcellulose particularly advantageous from the group of polyacrylates, preferably a polyacrylate from the group of so-called Carbopols, for example Carbopols types 980, 981, 1382, 2984, 5984, each individually or in combination.
  • Carbopols for example Carbopols types 980, 981, 1382, 2984, 5984, each individually or in combination.
  • Gels used according to the invention usually contain alcohols of low carbon number, for example ethanol, isopropanol, 1, 2-propanediol, glycerol and water or an above-mentioned oil in the presence of a thickener, which in oily-alcoholic gels preferably silica or an aluminum silicate, in aqueous alcoholic or alcoholic gels preferably a polyacrylate.
  • alcohols of low carbon number for example ethanol, isopropanol, 1, 2-propanediol, glycerol and water or an above-mentioned oil in the presence of a thickener, which in oily-alcoholic gels preferably silica or an aluminum silicate, in aqueous alcoholic or alcoholic gels preferably a polyacrylate.
  • Fixed pins contain e.g. natural or synthetic waxes, fatty alcohols or fatty acid esters.
  • liquid oils eg paraffin oils, castor oil, isopropyl myristate
  • semi-solid constituents eg petrolatum, lanolin
  • solid constituents eg beeswax, ceresin and microcrystalline Waxes or ozokerite
  • high-melting waxes eg carnauba wax, candelilla wax
  • Suitable propellants for sprayable from aerosol containers cosmetic and / or dermatological preparations in the context of the present invention the usual known volatile, liquefied propellants, such as hydrocarbons (propane, butane, isobutane) are suitable, which can be used alone or in mixture with each other. Also, compressed air is advantageous to use.
  • hydrocarbons propane, butane, isobutane

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne des préparations cosmétiques ou dermatologiques ayant une certaine teneur en hibifoline.
PCT/EP2016/057888 2015-04-22 2016-04-11 Utilisation de l'hibifoline contre le vieillissement de la peau WO2016169798A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102015207267.3 2015-04-22
DE102015207267.3A DE102015207267A1 (de) 2015-04-22 2015-04-22 Verwendung von Hibifolin gegen Hautalterung

Publications (1)

Publication Number Publication Date
WO2016169798A1 true WO2016169798A1 (fr) 2016-10-27

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PCT/EP2016/057888 WO2016169798A1 (fr) 2015-04-22 2016-04-11 Utilisation de l'hibifoline contre le vieillissement de la peau

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DE (1) DE102015207267A1 (fr)
WO (1) WO2016169798A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107619422A (zh) * 2017-10-27 2018-01-23 北京理工大学 一种制备高纯度棉皮素‑8‑o‑葡萄糖醛酸苷的方法

Citations (3)

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US4144325A (en) 1976-11-10 1979-03-13 Voyt Walter F Method of and composition for preventing sunburn while affording tanning
US4248861A (en) 1979-02-21 1981-02-03 Schutt Steven R Skin treatment methods
US20070065396A1 (en) * 2005-09-21 2007-03-22 Tracie Martyn International, Llc Topical macqui berry formulation

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US20050090553A1 (en) * 1992-06-30 2005-04-28 Shapiro Howard K. Compositions and method for treatment of chronic inflammatory diseases
US20030125264A1 (en) * 2001-12-29 2003-07-03 Kimberly-Clark Worldwide, Inc. Methods For Treating Wounds
US7776915B2 (en) * 2005-03-24 2010-08-17 Tracie Martyn International, Llc Topical formulations and methods of use

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US4144325A (en) 1976-11-10 1979-03-13 Voyt Walter F Method of and composition for preventing sunburn while affording tanning
US4248861A (en) 1979-02-21 1981-02-03 Schutt Steven R Skin treatment methods
US20070065396A1 (en) * 2005-09-21 2007-03-22 Tracie Martyn International, Llc Topical macqui berry formulation

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PANDURANGAN N ET AL: "Synthesis and antioxygenic activities of seabuckthorn flavone-3-ols and analogs", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 21, no. 18, 14 July 2011 (2011-07-14), pages 5328 - 5330, XP029121389, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2011.07.008 *
SANZ M J ET AL: "INFLUENCE OF A SERIES OF NATURAL FLAVONOIDS ON FREE RADICAL GENERATING SYSTEMS AND OXIDATIVE STRESS", XENOBIOTICA, TAYLOR AND FRANCIS, LONDON, GB, vol. 24, no. 7, 1 January 1994 (1994-01-01), pages 689 - 699, XP008020190, ISSN: 0049-8254 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107619422A (zh) * 2017-10-27 2018-01-23 北京理工大学 一种制备高纯度棉皮素‑8‑o‑葡萄糖醛酸苷的方法

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