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WO2016039333A1 - Dispositif de piqûre - Google Patents

Dispositif de piqûre Download PDF

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Publication number
WO2016039333A1
WO2016039333A1 PCT/JP2015/075453 JP2015075453W WO2016039333A1 WO 2016039333 A1 WO2016039333 A1 WO 2016039333A1 JP 2015075453 W JP2015075453 W JP 2015075453W WO 2016039333 A1 WO2016039333 A1 WO 2016039333A1
Authority
WO
WIPO (PCT)
Prior art keywords
blade
puncture device
blade portion
base
view
Prior art date
Application number
PCT/JP2015/075453
Other languages
English (en)
Japanese (ja)
Inventor
重幸 山添
Original Assignee
株式会社かいわ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2015175878A external-priority patent/JP5967595B2/ja
Application filed by 株式会社かいわ filed Critical 株式会社かいわ
Priority to US15/509,486 priority Critical patent/US20170259053A1/en
Priority to EP15840118.2A priority patent/EP3192557B1/fr
Publication of WO2016039333A1 publication Critical patent/WO2016039333A1/fr
Priority to US16/210,457 priority patent/US20190105482A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Definitions

  • the present invention relates to a puncture device, and relates to a puncture device used for transdermally administering a drug.
  • a puncture device As a puncture device, there is disclosed a microneedle device that includes a plurality of fine needles that can puncture the skin and that can administer a drug non-invasively.
  • the microneedle device administers a drug transcutaneously by puncturing the stratum corneum, which is the outermost layer of the skin, with a fine needle.
  • Various sizes and shapes of microneedles have been proposed to promote percutaneous absorption of drugs (for example, Patent Document 1).
  • Patent Document 1 discloses a fine needle having a cone shape or a knife shape. It is disclosed that the fine needle can be formed of metal, ceramic, or plastic.
  • the tip of the fine needle disclosed in Patent Document 1 is thin, for example, when it is formed of plastic, the tip is deformed when pressed against the skin, and the skin is punctured to such an extent that a drug can be administered. There is a problem that can not be.
  • an object of the present invention is to provide a puncture device that can puncture the skin more reliably.
  • the puncture device comprises a base and a plurality of blades formed on the base, wherein the blades are flat and the tip is formed in a mountain shape. .
  • the blade portion is flat, it is less likely to be deformed than the needle shape, and the tip portion is formed in a mountain shape, so that it is easily pierced into the skin.
  • the blade portion can be cut in the skin by being moved in the longitudinal direction of the needle teeth while being pressed against the skin and applied with a force in one direction. Therefore, the puncture device can puncture the skin more reliably by including a plurality of blade portions that can cut the skin.
  • FIG. 2A is a front view
  • FIG. 2B is a top view
  • FIG. 2C is a side view.
  • FIG. 3A is a front view
  • FIG. 3B is a top view
  • FIG. 3C is a side view.
  • FIG. 4A is a front view
  • FIG. 4B is a top view
  • FIG. 4C is IVC sectional drawing of FIG.
  • FIG. 5A is a front view
  • FIG. 5B is a top view
  • FIG. 5C is VC sectional drawing of FIG.
  • FIG. 6A is a top view
  • FIG. 6B is a X arrow directional view
  • FIG. 6C is VIC sectional drawing of FIG.
  • FIG. 7A is a front view
  • FIG. 7B is a top view
  • FIG. 7C is a side view.
  • FIG. 8A is a front view
  • FIG. 8B is a top view
  • FIG. 8C is VIIIC sectional drawing of FIG.
  • FIG. 9A is a front view
  • FIG. 9B is a top view
  • FIG. 9C is a side view.
  • a puncture device 10 shown in FIG. 1 includes a base portion 12 and a puncture portion 14 and is formed of a synthetic resin, for example, a thermoplastic resin.
  • the base 12 shown in this figure is formed in a disk shape.
  • a puncture portion 14 is formed on one side surface of the base portion 12.
  • the puncture device 10 may be formed with a flow path 18 for guiding a drug.
  • the flow path 18 is configured by a hole penetrating in the thickness direction of the base portion 12.
  • the puncture unit 14 includes a plurality of blade portions 16A.
  • the puncture part 14 may form a metal film on the surface in order to improve mechanical strength.
  • the blade portion 16A is flat, and the front end portion 17 is formed in a mountain shape in a front view.
  • the blade portion 16A has a tip portion 17 that is gently curved in a front view, expands in the width direction toward the proximal end, and is formed in a mountain shape like a shark's teeth as a whole. ing.
  • the blade portion 16A has a substantially elliptical shape in plan view.
  • the blade portion 16A has a thick base end and a tapered shape from the base end toward the front end in a side view. 16 A of blade parts shown to this figure have a shape similar to the side surface of a clam in side view.
  • the blade portion 16A formed in this way is arranged on the base portion 12 with the direction of the distal end portion 17 aligned (the arrow direction in FIG. 2B) to form the puncture portion 14 (FIG. 1). .
  • the puncture device 10 can be produced by general injection molding.
  • the mold (not shown) is preferably formed by combining a plurality of molds in accordance with the shape of the puncture device 10.
  • the blade portion 16A can be formed by a die that is divided into two in the thickness direction. Then, after the molten thermoplastic resin is poured into the mold and held for a predetermined time, the puncture device 10 can be obtained by opening the mold.
  • the puncture device 10 configured as described above is attached to a device (not shown) in which the other side of the base 12 holds a medicine. Then, the puncture unit 14 is brought into contact with the skin and is slid in one direction, for example, left and right (in the direction of the arrow in FIG. 2B) while being pressed in the longitudinal direction. Then, the puncture unit 14 punctures the stratum corneum of the skin. Thereby, the medicine guided from the other surface of the base 12 to the one surface through the flow path 18 formed in the base 12 is transcutaneously administered through the cut of the skin cut by the puncture unit 14.
  • the blade portion 16A constituting the puncture portion 14 is flat, and the distal end portion 17 is formed in a mountain shape in front view. Easy to bite into.
  • the blade portion 16A can cut the skin by applying a force in one direction while being pressed against the skin. Therefore, the puncture device 10 can puncture the skin more reliably by including the puncture portion 14 including the plurality of blade portions 16A that can cut the skin.
  • the blade portion 16A has a thick base end in a side view and is formed in a tapered shape from the base end toward the front end, so that the front end is deformed when pressed against the skin. Can be suppressed.
  • the blade part according to the present embodiment is different from the first embodiment in that a drug penetrating part is formed.
  • the blade part according to the present embodiment will be described with reference to FIG. 3 with the same reference numerals as in FIG.
  • the blade portion 16B shown in FIG. 3 is flat, the front end portion 17 is formed in a mountain shape in a front view, and a widened portion 20 as a drug permeation portion is provided.
  • the widened portion 20 is configured by a ridge formed linearly from the proximal end of the blade portion 16B toward the distal end.
  • the widened portion 20 is formed on both surfaces of the blade portion 16B and substantially at the center in a front view.
  • the blade portion 16B is flat, and when the front end portion 17 is formed in a mountain shape in a front view, the same effect as in the first embodiment can be obtained. Furthermore, the blade portion 16B widens the cut formed in the skin by the widened portion 20 when the skin is cut. The drug penetrates into the skin through the cut surface widened by the blade portion 16B and the widened portion 20. This allows the drug to be administered more efficiently.
  • the drug penetrating part is not limited to the widened part 20 and may be constituted by a groove 22 as shown in FIG.
  • the groove 22 is configured by a groove 22 formed linearly from the base end of the blade portion 16C toward the tip end.
  • the grooves 22 are formed on both surfaces of the blade portion 16C and substantially at the center when viewed from the front.
  • a gap is formed by the groove 22 between the cut end and the blade portion 16C. The drug penetrates into the skin through the gap. This allows the drug to be administered more efficiently.
  • the blade portion 16C may form a flow path at the base portion at the base end of the groove 22.
  • the flow path is preferably formed by a hole penetrating the base in the thickness direction.
  • the blade part comprises the blade edge
  • the puncture portion of the puncture device is constituted by the plurality of bladed drug supply bodies. In such a puncture device, the blade portion is fixed to the base portion via the support portion.
  • the bladed medicine supply body having a blade portion as a blade edge will be described with reference to FIG.
  • This puncture device can be used by attaching it to a syringe or the like to supply a chemical solution like an injection.
  • the puncture device includes a through hole for supplying a chemical solution.
  • a support portion 38 ⁇ / b> A is integrally provided at the proximal end of the blade portion 36.
  • the bladed medicine supply body 30A cuts the skin with the blade part 36 constituting the blade edge to form a cut end.
  • the blade portion 36 has substantially the same configuration as the blade portion 16A of the first embodiment.
  • the blade part 36 is flat, and the front-end
  • the blade portion 36 has a substantially elliptical shape in plan view.
  • the blade portion 36 also has a point that the distal end portion 37 is gently curved and expands in the width direction toward the proximal end in a front view, and has a mountain shape like a shark tooth as a whole. It is almost the same as the part 16A.
  • the blade part 36 comprises the blade edge
  • the bladed medicine supply body 30A can be configured to have the same shape and size as the blade portion 16A as a whole in front view. As will be described later, since the support portion 38A is required to have a certain thickness, the thickness of the bladed drug supply body 30A is larger than that of the blade portion 16A.
  • the support portion 38A is interposed between a base portion (not shown) and the blade portion 36, and supports the blade portion 36. Furthermore, as will be described later, the support portion 38A supplies the medicine guided from the base portion to the blade portion 36 or the cut end.
  • the support portion 38A has an isosceles trapezoidal shape when viewed from the front. Since the support portion 38 ⁇ / b> A is integrally provided at the base end of the blade portion 36, the upper end of the support portion 38 ⁇ / b> A coincides with the base end of the blade portion 36. Since the through hole 32 is provided inside the support portion 38A, the support portion 38A is required to have a certain thickness. In the present embodiment, the support portion 38A has a bottom surface that is substantially circular in a plan view.
  • the through-hole 32 is formed inside the support portion 38A so that the medicine can be supplied to the blade portion 36 from the base flow path.
  • One end of the through hole 32 communicates with the flow path, and the other end of the through hole 32 reaches the blade portion 36. Accordingly, the medicine can be directly guided from the other side surface of the base to the blade portion 36 through the base flow path and the through hole 32 of the support portion 38A.
  • the cross-sectional shape in the lateral direction of the through hole 32 is not particularly limited, but is substantially circular in the present embodiment.
  • the shape of the support portion 38A is particularly limited as long as the blade portion 36 that is flat and has a mountain-shaped tip portion 37 is integrally provided at the upper end and the through-hole 32 for guiding the drug to the blade portion 36 can be formed inside. It can be configured in any shape.
  • a plurality of bladed drug supply bodies 30A provided with a support portion 38A provided integrally at the lower end of the blade portion 36 and having the blade portion 36 as a cutting edge constitute a puncture portion of the puncture device.
  • a puncture device including a plurality of bladed drug supply bodies 30A as a puncture unit can be manufactured by general injection molding as in the first embodiment.
  • the mold (not shown) is preferably formed by combining a plurality of molds so that the support part 38A and the blade part 36 integrated as described above can be formed.
  • the bladed drug supplier 30A includes a rod for forming the through-hole 32 inside the support portion 38A, and can be formed by a die that is divided into two in the thickness direction.
  • the puncture device of this embodiment can be obtained in the same manner as in the first embodiment except that a predetermined mold is used.
  • the blade portion 36 is flat and the tip portion 37 is formed in a mountain shape in a front view, so that the same effect as in the first embodiment can be obtained.
  • the through-hole 32 inside the support portion 38A in the bladed drug supply body 30A is provided in communication with a base channel not shown. Since the support portion 38A has the through-hole 32 communicated with the flow path, when the skin is cut by the blade portion 36, the drug enters the through-hole 32 of the support portion 38A from the other side surface of the base through the flow path. Led.
  • the medicine is supplied from the open end 34 of the through hole 32 to the blade portion 36 of the blade edge and permeates into the skin from the cut end. Thereby, since a chemical
  • the skin is cut by the blade portion 36, by inserting a puncture device, at least a part of the open end 34 of the through-hole 32 in the bladed drug supply body 30A is inserted into the cut end to administer the drug. it can.
  • the medicine guided from the other side surface of the base through the flow path is directly supplied from the open end 34 into the cut end. Therefore, the drug can be administered more efficiently.
  • the opening end 34 in the support portion 38A is not limited to one, and a plurality of opening ends may be provided.
  • the open ends 34 can be provided on both sides of the support portion 38B with the blade portion 36 interposed therebetween as shown in FIG.
  • the support portion 38 ⁇ / b> B is integrally provided at the base end of the blade portion 36.
  • An X arrow view of the bladed medicine supply body 30B provided with such a support portion 38B is as shown in FIG. 6B.
  • the Y arrow view of the bladed drug supplier 30A is the same as the front view of FIG. 5A.
  • the two open ends 34 in the bladed drug supply body 30B are open ends of a single through hole 32 as shown in the VIC cross-sectional view of FIG. 6C, but may be open ends of separate through holes.
  • the presence of the two open ends 34 increases the amount of the medicine supplied to the blade 36 through the through hole 32, so that the administration efficiency is further increased.
  • the present invention is not limited to the above-described embodiment, and can be appropriately changed within the scope of the gist of the present invention.
  • a substantially semicircular blade portion 16 ⁇ / b> D may be used in front view.
  • the blade portion 16D is flat, and the front end portion 17 is formed in a mountain shape in a front view, so that the same effect as in the first embodiment can be obtained.
  • the blade portion 16 ⁇ / b> E may have a saw tooth 24 at the tip portion 17.
  • the blade portion 16E can cut the skin more efficiently.
  • the blade portion 16F may include a plate-like base end portion 26 and a tip end portion 28 formed in a mountain shape.
  • the blade portion 16F has an oval shape in plan view.
  • the blade portion 16F is flat, and when the front end portion 28 is formed in a mountain shape in a front view, the same effect as in the first embodiment can be obtained.
  • the blade portion 16F can form the tip end portion 28 sharply. Therefore, the blade portion 16F can cut the skin more efficiently.
  • the blades 16D to 16F according to the modified example may be provided with the drug permeation unit described in the second embodiment. It is also possible to configure the bladed drug supply body by appropriately sizing the blade portions 16D to 16F according to the above modification and integrally providing the support portion shown in the third embodiment at the lower end thereof. Furthermore, it is good also as forming a puncture part combining various blade parts which concern on the said embodiment and modification.
  • the central blade portion may protrude in the distal direction from the peripheral blade portion.
  • the puncture portion having such a shape can be obtained by forming the center of the base portion so as to be convex toward the distal end direction of the blade portion. As a result, the puncture device can form a cut having substantially the same depth with respect to the skin in the entire puncture portion.
  • the puncture device is formed of a synthetic resin.
  • the present invention is not limited to this, and the puncture device is formed of a metal such as polylactic acid biodegradable resin, stainless steel, titanium, silver, and gold. Also good.
  • a metal film can be provided on the surface of the blade portion in order to increase the mechanical strength.
  • the puncture device is formed of metal, a laminated film of different metals may be used. In the metal laminated film, plating with higher strength is provided on the surface in order to further increase the mechanical strength.
  • Plating is effective for increasing the strength of a puncture device made of a metal such as stainless steel or a synthetic resin.
  • the plating should be selected from, for example, bright chrome, velor chrome, bright nickel, velor nickel, bright tin cobalt, velor's cobalt, bright gold, velor gold, trivalent chrome, bright noble, velor no broy, rhodium, and platinum plating. Can do.
  • the flow path is a hole formed in the thickness direction of the base
  • the present invention is not limited to this.
  • the channel in the first and second embodiments may be a groove formed on the side surface of the base.
  • the drug is guided from the other surface of the base to the one side surface through the channel formed in the base and is administered transcutaneously, and from the channel formed in the base.
  • the percutaneous from the cut end By being guided to the blade part through the through hole provided in the support part in the bladed drug supply body, or by directly supplying the cut end from the open end of the through hole provided in the support part, the percutaneous from the cut end.
  • the present invention is not limited to this.
  • the medicine may be applied to the blade part in advance, and may be transcutaneously administered through the cut at the same time as the skin is cut.
  • the base has a disk shape
  • the present invention is not limited to this and may be a triangular or quadrangular plate member.
  • the blade portion has been described with respect to the case where the tip portion is gently curved in the front view, but the present invention is not limited to this, and the tip portion may be sharp in the front view.
  • the blade portion 46 may have a substantially isosceles triangular shape in a side view.
  • the blade part 48 is good also as having the shape which connected the base end formed thickly and the taper-shaped front-end
  • the thickness of the support portions 38A and 38B of the bladed drug solution supply bodies 30A and 30B is not particularly limited as long as the through holes 32 can be formed inside.
  • the blade portion 36 may be provided not only at the distal end portion 37 of the bladed chemical solution supply bodies 30A and 30B but also over the entire outer edge of the bladed chemical solution supply bodies 30A and 30B.
  • the third embodiment can be combined with the second embodiment.
  • the grooves 22 as shown in FIG. 4 may be formed on both surfaces, and the through holes 32 may be provided so as to open inside the grooves 22.
  • channel 22 can be provided from the height of about 1/3 from the bottom of the base end of bladed chemicals supply body 30A, 30B.
  • the angle of the tip in side view can be about 15 °.
  • the groove 22 is not limited to a straight shape, and an angle of about 6 ° may be provided.
  • Puncture device 12 Base part 14 Puncture part 16A-16F, 36, 46, 48 Blade part 17, 28, 37 Tip part 18 Channel 20 Widening part (drug penetration part) 22 Groove (drug penetration part) 24 sawtooth 26 base end portion 38A, 38B support portion 30A, 30B bladed drug supply body 32 through hole 34 open end

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention comprend une partie de base (12) et de multiples parties de lame (16A) formées sur la partie de base (12), les parties de lame (16A) étant plates et les pointes étant en forme de chevron.
PCT/JP2015/075453 2014-09-08 2015-09-08 Dispositif de piqûre WO2016039333A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US15/509,486 US20170259053A1 (en) 2014-09-08 2015-09-08 Puncture device
EP15840118.2A EP3192557B1 (fr) 2014-09-08 2015-09-08 Dispositif de piqûre
US16/210,457 US20190105482A1 (en) 2014-09-08 2018-12-05 Puncture device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2014182572 2014-09-08
JP2014-182572 2014-09-08
JP2015-175878 2015-09-07
JP2015175878A JP5967595B2 (ja) 2014-09-08 2015-09-07 穿刺器具

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US15/509,486 A-371-Of-International US20170259053A1 (en) 2014-09-08 2015-09-08 Puncture device
US16/210,457 Division US20190105482A1 (en) 2014-09-08 2018-12-05 Puncture device

Publications (1)

Publication Number Publication Date
WO2016039333A1 true WO2016039333A1 (fr) 2016-03-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2015/075453 WO2016039333A1 (fr) 2014-09-08 2015-09-08 Dispositif de piqûre

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Country Link
WO (1) WO2016039333A1 (fr)

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457041A (en) * 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
JP2000512529A (ja) * 1996-06-18 2000-09-26 アルザ コーポレイション 薬剤の経皮放出又はサンプリングを高めるための装置
JP2003093521A (ja) * 2001-09-26 2003-04-02 Terumo Corp 薬剤投与具及び薬剤投与装置
JP2004516868A (ja) * 2000-10-16 2004-06-10 ザ プロクター アンド ギャンブル カンパニー 皮膚を介して組成物を皮膚に送達するための微細構造
JP2004526581A (ja) * 2001-03-14 2004-09-02 ザ プロクター アンド ギャンブル カンパニー ソフトリソグラフィ及びフォトリソグラフィを使用して微小針（ｍｉｃｒｏｎｅｅｄｌｅｓ）構造を製造する方法
JP2008528192A (ja) * 2005-01-31 2008-07-31 アルザ コーポレイション 低い変動性を有するコーティングマイクロプロジェクション、及びその生成法
JP2009502261A (ja) * 2005-07-25 2009-01-29 ナノテクノロジー ビクトリア ピーティーワイ リミテッド マイクロアレイデバイス
WO2009014805A2 (fr) * 2007-05-29 2009-01-29 University Of Utah Research Foundation Réseaux de micro-aiguilles à extrémités non planes et leurs procédés de fabrication
JP2009535122A (ja) * 2006-04-25 2009-10-01 アルザ コーポレイション 高薬物充填のための造形された微小突起をもつ微小突起アレイ適用
DE102008052702A1 (de) * 2008-10-22 2010-04-29 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Nadelanordnung, Spritzgussform und Verfahren zum Herstellen
JP2012532709A (ja) * 2009-07-15 2012-12-20 デバイオテック・ソシエテ・アノニム 多チャンネル・マイクロニードル
JP2013513408A (ja) * 2009-12-11 2013-04-22 キンバリー クラーク ワールドワイド インコーポレイテッド 経皮送達デバイス
JP2014519385A (ja) * 2011-06-10 2014-08-14 キンバリー クラーク ワールドワイド インコーポレイテッド マイクロニードルを含む経皮装置

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457041A (en) * 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
JP2000512529A (ja) * 1996-06-18 2000-09-26 アルザ コーポレイション 薬剤の経皮放出又はサンプリングを高めるための装置
JP2004516868A (ja) * 2000-10-16 2004-06-10 ザ プロクター アンド ギャンブル カンパニー 皮膚を介して組成物を皮膚に送達するための微細構造
JP2004526581A (ja) * 2001-03-14 2004-09-02 ザ プロクター アンド ギャンブル カンパニー ソフトリソグラフィ及びフォトリソグラフィを使用して微小針（ｍｉｃｒｏｎｅｅｄｌｅｓ）構造を製造する方法
JP2003093521A (ja) * 2001-09-26 2003-04-02 Terumo Corp 薬剤投与具及び薬剤投与装置
JP2008528192A (ja) * 2005-01-31 2008-07-31 アルザ コーポレイション 低い変動性を有するコーティングマイクロプロジェクション、及びその生成法
JP2009502261A (ja) * 2005-07-25 2009-01-29 ナノテクノロジー ビクトリア ピーティーワイ リミテッド マイクロアレイデバイス
JP2009535122A (ja) * 2006-04-25 2009-10-01 アルザ コーポレイション 高薬物充填のための造形された微小突起をもつ微小突起アレイ適用
WO2009014805A2 (fr) * 2007-05-29 2009-01-29 University Of Utah Research Foundation Réseaux de micro-aiguilles à extrémités non planes et leurs procédés de fabrication
DE102008052702A1 (de) * 2008-10-22 2010-04-29 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Nadelanordnung, Spritzgussform und Verfahren zum Herstellen
JP2012532709A (ja) * 2009-07-15 2012-12-20 デバイオテック・ソシエテ・アノニム 多チャンネル・マイクロニードル
JP2013513408A (ja) * 2009-12-11 2013-04-22 キンバリー クラーク ワールドワイド インコーポレイテッド 経皮送達デバイス
JP2014519385A (ja) * 2011-06-10 2014-08-14 キンバリー クラーク ワールドワイド インコーポレイテッド マイクロニードルを含む経皮装置

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