WO2016030060A1

WO2016030060A1 - Anti body odor preparations which are low in electrolytes

Info

Publication number: WO2016030060A1
Application number: PCT/EP2015/065181
Authority: WO
Inventors: Thomas Döring; Gertraud Teckenbrock
Original assignee: Henkel Ag & Co. Kgaa
Priority date: 2014-08-29
Filing date: 2015-07-03
Publication date: 2016-03-03
Also published as: DE102014217316A1

Abstract

The present invention relates to aqueous-ethanolic cosmetic deodorants which are filled into and stored in metal containers, i.e. in particular containers having metal inner surfaces or elements that are in contact with the deodorant, without appreciable corrosion taking place.

Description

"Low-electrolyte preparations against body odor"

The present application relates to aqueous-ethanolic cosmetic deodorants used in metallic containers, i. in particular containers with metallic inner surface or elements that are in contact with the deodorant, filled and stored without significant corrosion occurs.

Washing, cleansing and caring for one's own body is a fundamental human need, and modern industry is constantly trying to meet these needs of man in a variety of ways. Especially important for daily hygiene is the permanent elimination or at least reduction of body odor. Numerous specific deodorant or antiperspirant personal care products are known in the art which have been developed for use in body regions having a high density of sweat glands, especially in the underarm area. These are formulated in a wide variety of dosage forms, for example as powder, in stick form, as aerosol spray, pump spray, liquid and gel roll on application, cream, gel and as a soaked flexible substrate (towels).

Cosmetic compositions, especially deodorants and antiperspirants, usually contain at least one oil or one fatty substance and in any case always a fragrance component or a perfume.

Ethanol is a preferred solvent in deodorants as it provides a cool and fresh-to-dry sensation to the skin when applied to the skin. The preferred form of application here are aerosols. To improve the compatibility of deodorant compositions with metal packaging, particularly when using tinplate valve plates, high purity 99.5 to 100% ethanol (200 proof) ethanol is often used. On the other hand, using water-based ethanol of 95 to 99.5% (190 proof) may cause corrosion. However, high-purity ethanol is not always commercially available and, compared to water-containing ethanol, more expensive to produce and therefore also more expensive.

As expected, the risk of corrosion is significantly increased in the presence of electrolytes. Active substances to prevent body odor are often electrolytes, e.g. Cocamidopropyl PG-Dimonium Chloride Phosphate, Silver Lactate, Zinc Ricinoleate, Aluminum Sulfate, Polyamino Biguanide Stearate etc.

By using nonionic agents to prevent body odor, such as phenoxyethanol, triethyl citrate or 1, 2-alkanediols, while the electrolyte concentration can be kept lower, but corrosion problems are still common. It has now surprisingly been found according to this invention that ethanol-containing preparations with water contents of z. B. 1 to 5 wt .-% and over more than 24h lasting effect against body odor without risk of corrosion in metal aerosol containers can be stored if the electrical conductivity of the preparation is less than 50 μβ / ϋΐη and at least two different alcohols or polyols with 8 or more carbon atoms are contained as deodorant agents in a total concentration of at least 0.5 wt .-%.

The present application thus provides:

1. A deodorant cosmetic agent in a container which has at least one metallic surface area in contact with the cosmetic agent during storage or dosage of the cosmetic agent and / or at least one metallic component in contact with the cosmetic agent, the cosmetic agent containing :

0.1 to 5.0% by weight of water,

- ethanol

0.1 to 5.0% by weight of at least two different nonionic saturated aliphatic alcohol compounds having 8 or more carbon atoms as deodorant active ingredients, the weight percentages in each case referring to the total weight of the composition according to the invention, without to consider existing propellants, and

wherein the cosmetic agent has an electrical conductivity of 50 μβ / ϋΐη or less.

2. Cosmetic composition according to item 1, wherein the container is a metal aerosol spray container.

3. A cosmetic composition according to item 1 or 2, wherein the aliphatic alcohol compounds are selected from the group consisting of a saturated aliphatic compound having one or more 1,2-alkanediol group (s) and a monohydric alcohol.

4. Cosmetic agent according to one of the preceding points, wherein the compound having one or more 1, 2-alkanediol group (s) a linear or branched 1, 2-alkanediol having 8 to 12 carbon atoms, a linear or branched 1, 2-alkane diol ethers 8 to 30 carbon atoms and / or a linear or branched 1, 2-alkanediol ester having 8 to 30 carbon atoms. 5. Cosmetic agent according to one of the preceding points, wherein the 1, 2-alkanediol is 1, 2-octanediol and / or 1, 2-decanediol.

6. Cosmetic agent according to one of the preceding points, wherein the 1, 2-alkanediol ether is an a- monoalkyl glycerol ether having a branched or linear saturated or unsaturated C 8 -C 22 alkyl radical, preferably α - (2-ethylhexyl) glycerol ether.

7. Cosmetic composition according to one of the preceding points, wherein the 1, 2-alkanediol ester is a carboxylic acid ester of mono-, di- and / or triglycerol, preferably glycerol monocaprylate (INCI: glyceryl caprylates), glycerol dicaprylates (INCI: polyglyceryl 2-caprylates) and / or glycerol tricaprylates (INCI: polyglyceryl 3-caprylates).

A cosmetic composition according to any preceding item, wherein the monohydric alcohol is a linear or branched alcohol having 8 to 30 carbon atoms and a terminal OH group which preferably has an alicyclic ring.

9. Cosmetic composition according to item 8, wherein the monohydric alcohol is 2-methyl-5-cyclohexylpentanol.

10. Cosmetic composition according to one of the preceding claims, wherein the agent further comprises one or more of the following compounds: phenoxyethanol, one or more tropolones, triethyl citrate.

1 1. Cosmetic composition according to one of the preceding claims, wherein the agent contains as deodorant active ingredient 1, 2-octanediol and further 1, 2-hexanediol.

12. A cosmetic composition according to any one of the preceding claims, wherein the agent contains 0.5 to 5.0 wt .-% water and 0.5 to 5.0 wt .-% of at least two aliphatic alcohol compounds having 8 or more carbon atoms.

13. Use of a cosmetic agent which 0, 1 to 5.0 wt .-% water, ethanol and 0.1 to 5.0 wt .-% of at least two different nonionic saturated aliphatic alcohol compounds having 8 or more carbon atoms as deodorant agents contains, and which has an electrical conductivity of 50 μβ / ϋΐη or less, as the content of a container such that at least one metallic surface area and / or at least one metallic component of the container is in contact with the cosmetic agent during storage or dosage of the cosmetic product , 14. A method for non-therapeutic, cosmetic deodorant treatment of the body, wherein the deodorant described in any one of items 1 to 12 from the container on the skin, in particular the skin of the armpits, is applied.

15. A process for the preparation of a deodorant cosmetic agent in the form of an aerosol, which comprises using a cosmetic agent which contains 0, 1 to 5.0% by weight of water, ethanol and 0, 1 to 5.0% by weight. containing at least two different nonionic saturated aliphatic alcohol compounds having 8 or more carbon atoms as deodorant agents, and having an electrical conductivity of 50 μβ / ϋΐη or less, optionally together with a blowing agent, fills in an aerosol spray container, which at least one metallic surface area and / or at least one metallic component which is in contact with the cometic agent upon storage or dosage of the cosmetic composition.

With regard to preferred embodiments of the method according to the invention and the use according to the invention, what has been said about the agents according to the invention applies mutatis mutandis.

Basically, all containers are suitable according to the invention as a container, which have a surface at risk of corrosion of a corrosion-prone component, that is, for example, a surface or a component made of aluminum or tinplate.

Inventive agents are preferably packaged for use as aerosol, that is, they are packaged in a pressure vessel, from which they can be sprayed by means of a propellant. The packaging in other dosage forms, such as in a deodorant scooter with metallic inner surface, but is also included according to the invention. In a preferred embodiment, the agents according to the invention are in liquid or viscous, flowable form. The application is preferably carried out with spray devices. These spraying devices contain in a container a filling of the liquid, viscous-flowable or suspensionsformigen deodorant according to the invention. The filling is usually under the pressure of a propellant (compressed gas cans, aerosols, aerosols). The containers have a removal device, preferably in the form of valves, which allow the removal of the contents as fog, smoke, foam, powder, paste or liquid jet. As a container for the sprayers are mainly cylindrical vessels made of metal (aluminum, tinplate, volume preferably a maximum of 1000 ml) in question. Even containers made of protected or non-shattering glass or plastic (volume preferably up to 220 ml) or splintering glass or plastic (volume preferably up to 150 ml), which have a component or a surface made of metal, which / may be subject to corrosion coming in question. Creamy, gelatinous, pastose and liquid agents may be packaged, for example, in pump, spray or squeeze dispensers, in particular also in multi-chamber pumping, multi-chamber spray or multi-chamber Quetschspendern. The packaging for the compositions according to the invention may be opaque, but also transparent or translucent.

For the purposes of the invention, the term liquid also includes any solid dispersions in liquids. Compositions according to the invention may also be present as pastes, ointments, lotions or creams. Solid funds can be present as a loose powder, pressed powder or as a pen.

In the case of liquid or low to medium-viscosity agents, the application can also be carried out with a roller applicator, as described e.g. is known from the field of deodorant scooters. Such scooters have a ball mounted in a ball bed which can be moved by movement over a surface. The ball absorbs some of the agent to be distributed and conveys this to the surface to be treated.

The agents according to the invention, preferably liquid agents, may also be multiphase, the phases may e.g. horizontally, so one above the other, or vertically, so next to each other, be arranged. It may also be a disperse system in which e.g. the solid constituents are distributed inhomogeneously in the liquid matrix, so that such a dispersed system should be shaken before use.

It should be noted at this point that the statement wt .-%, unless stated otherwise, in each case refers to the total weight of the agent according to the invention, without taking into account any existing propellant.

The terms "agent according to the invention" and "composition according to the invention" are used synonymously in the present application.

For the purposes of the present application, "normal conditions" are a temperature of 20 ° C. and a pressure of 1013.25 mbar. Melting point data likewise relate to a pressure of 1013.25 mbar.

The compositions according to the invention comprise as cosmetically acceptable carriers 0, 1 to 5.0% by weight of water, preferably 0.5 to 5.0% by weight of water, and ethanol. In embodiments, the cosmetically acceptable carrier is from 0.1 to 5.0% by weight of water and ethanol. Accordingly, according to the invention there is the great advantage that ethanol which is commercially available as a cosmetically acceptable carrier and having a water content of from 0.5 to 5.0% by weight can preferably be used. Agents preferred according to the invention, such as ethanol-based deodorant sprays, preferably contain from 1.0 to 4.5% by weight, also preferably from 1.5 to 4.0% by weight, more preferably from 2.5 to 4.0% by weight. % free, that is, not molecularly bound, water, with the quantities given refer to the weight of the composition, without taking into account any existing propellant. The content of water of crystallization, water of hydration or similar molecularly bound water, which is contained in the constituents used, does not constitute free water in the sense of the present application.

According to preferred embodiments of the invention, the cosmetic agent contains as a cosmetically acceptable carrier 96% ethanol in an amount of 60 to 97 wt.%, More preferably 70 to 95 wt .-%, further preferably 80 to 90 wt .-%, wherein the wt .-% - refer to the total weight of the composition, without taking into account any existing propellant.

According to the invention, however, it is also included that the cosmetically acceptable carrier may comprise further components, for example a cosmetic oil which is liquid under standard conditions and which is not a fragrance and is not an essential oil, and talcum and mixtures thereof. Under normal conditions liquid cosmetic oils are immiscible with water. As far as in the present application of a cosmetic oil is mentioned, this is always a cosmetic oil that is not a fragrance and no essential oil, is liquid under normal conditions and immiscible with water.

Compositions according to the invention are present as deodorants and contain as nonionic deodorant active ingredient at least two saturated aliphatic alcohol compounds having 8 or more carbon atoms in a total amount of 0.1-5.0% by weight, preferably 0.2-3.0% by weight. %, more preferably 0.3-2.0% by weight, also preferably 0.5-1.5% by weight, and most preferably 0.7-1.0% by weight, wherein the weight percentages % Information on the total weight of the composition, without taking into account any existing propellant.

According to the invention, ethanol does not count as a deodorant active ingredient, but, if present, only as a constituent of the carrier.

It is essential to the present invention that deodorant actives contain at least two different nonionic saturated aliphatic alcohol compounds having 8 or more carbon atoms in a proportion of 0.1 to 5.0% by weight. The alcohols may be monohydric alcohols or polyols.

The aliphatic alcohol compounds according to the invention are selected in particular from the group consisting of saturated aliphatic compounds with one or more 1, 2-alkanediol group (s) and monohydric alcohols.

The compound having one or more 1,2-alkanediol group (s) is preferably a linear or branched 1,2-alkanediol having 8 to 12 carbon atoms, a linear or branched 1, 2 Alkandiolether having 8 to 30 carbon atoms and / or a linear or branched 1, 2-alkanediol ester having 8 to 30 carbon atoms.

The 1,2-alkanediol is preferably a linear 1, 2-alkanediol having 8 to 12 carbon atoms, which is described by the formula HO-CH 2 -CH (OH) - (CH 2) n -CH ₃ , in which n is the numbers 5, 6, 7, 8 or 9, as well as mixtures of these 1, 2-alkanediols. 1, 2-alkanediols having 8 to 12 C atoms which are particularly preferred according to the invention are selected from 1,2-octanediol, 1,2-decanediol and mixtures thereof.

In a preferred embodiment of the invention, in addition to the 1,2-alkanediol having the formula HO-CH 2 -CH (OH) - (CH 2) n -CH ₃ , in which n is the number 5, 6, 7, 8 or 9 is one or more further alkanediols having 5 to 7 carbon atoms, in particular 1, 2-pentanediol and / or 1, 2-hexanediol.

For example, mixtures of 1, 2-hexanediol and 1, 2-octanediol, preferably in a weight ratio of 5: 1 to 1: 5, preferably in a weight ratio of about 1: 1 in the cosmetic composition. Such mixtures are commercially available, for example, under the name Symdiol® 68 (Symrise).

Preferred agents according to the invention comprise the at least one 1,2-alkanediol having 8 to 12 C atoms, which is described by the formula HO-CH 2 -CH (OH) - (CH 2) n -CH 3, in which n represents the numbers 5, 6, 7, 8 or 9, in a total amount of 0, 1-3 wt .-%, more preferably 0.2 to 1 wt .-%, particularly preferably 0.2 to 0.5 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.

According to the invention, the 1,2-alkanediol ether is preferably an α-monoalkyl glycerol ether having a branched or linear saturated or unsaturated C 8 -C 22 -alkyl radical. A preferred such 1, 2-alkanediol ether is α- (2-ethylhexyl) glycerol ether, commercially available as Sensiva® SC 50 (ex Schülke & Mayr). The 1,2-alkanediol ether is preferably contained in an amount of 0.2 to 1.0% by weight in the cosmetic composition, more preferably 0.3 to 0.5% by weight.

The linear or branched 1,2-alkanediol ester as deodorant active ingredient is preferably a carboxylic acid ester of mono-, di- or triglycerol. Examples of these are glycerol monolaurate, diglycerol monocaprate, triglycerol acrylate, diglyceryl acrylate and glycerol acrylate, of which triglyceryl acrylate (eg Tego® Cosmo P813, Evonik), diglycerol acrylate (eg Dermosoft® GMCY, Dr. Straetmans) and glycerol acrylate (eg Dermosoft® DGMC, Dr. Straetmans) are preferred , The 1,2-alkanediol ester is preferably present in an amount of 0.05 to 1.0% by weight in the cosmetic composition, furthermore preferably 0.1 to 0.5% by weight, and also preferably 0.2 to 0 , 3% by weight. The monohydric alcohol as the deodorant active is preferably a linear or branched alcohol having 8 to 30 carbon atoms, more preferably 8 to 12 carbon atoms, having a terminal OH group. Furthermore, the monohydric alcohol preferably has an alicyclic ring. A preferred example of such a deodorant active ingredient is 2-methyl-5-cyclohexylpentanol, commercially available, for example, as SymDeo® B125 (Symrise).

The monohydric alcohol is preferably contained in an amount of 0.1 to 1.0% by weight in the cosmetic composition, further preferably 0.2 to 0.8% by weight, also preferably 0.3 to 0.7% by weight .-%.

Another essential feature of the present invention is that the electrical conductivity of the cosmetic composition is 50 μβ / ϋΐη or less. The use of the above-mentioned nonionic deodorant active ingredients, in addition to avoiding other ionic components, contribute to a low electrical conductivity. However, maintaining the value of the electric conductivity of 50 μβ / ϋΐη or less alone is not enough to sufficiently reduce corrosion. It has been surprisingly found in the present invention, however, that this value or lower values of electrical conductivity in combination with the use of said nonionic deodorant agents in a concentration of at least 0.5 wt .-% of the occurrence of corrosion in containers with metallic surfaces and / or components that are in contact with the composition reliably and permanently prevented.

The value of the electrical conductivity was determined in the present invention using the Condhmometer 856 from Metrohm. The measuring cell with 5 rings (c = 1, 0 cm ^"1 ) from Metrohm was used as the sensor and the measurements were carried out at 23 ° C.

The electrical conductivity of the cosmetic composition is according to the invention 0 to 50 μβ / ϋΐη, preferably 20 to 45 μβ / ϋΐη, more preferably 30 to 40 μβ / αη.

In addition to the genannnten constituents of the cosmetic composition further ingredients may be included, in particular further deodorant agents.

In a preferred embodiment, the agents according to the invention comprise as further deodorizing agent at least one aromatic alcohol of structure (AA-1), R ⁵ R ³ R ¹

(- O -) - ( ^- C -) - (c) - (- C -) - OH

m ^{0 p}

R ⁶ R ⁴ R ²

_R 7-1 1

(AA-1)

in which

the radicals R to R ⁶ independently of one another represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, which may be linear or branched and substituted by OH groups or alkoxy groups having 1 to 5 carbon atoms, or an alkenyl group having 2 to 10 carbon atoms, which may be linear or branched and substituted with OH groups or alkoxy groups having 1 to 5 carbon atoms,

the radicals R ⁷ to R independently of one another are a hydrogen atom, a halogen atom, in particular a chlorine atom, or an alkyl group having 1 to 10 carbon atoms, which may be linear or branched and substituted by OH groups or alkoxy groups having 1 to 5 carbon atoms, in particular with a methoxy group,

m = 0 or 1, n, o, p = are independently integers from 0 to 10, with at least one of the values n, o, p Φ 0.

Particularly preferred products according to the invention contain at least one alcohol AA-1, as described above, which is selected from phenoxyethanol, anisalcohol, 2-methyl-5-phenylpentan-1-ol, 1, 1-dimethyl-3-phenylpropane 1-ol, benzyl alcohol, 2-phenylethan-1-ol, 3-phenylpropan-1-ol, 4-phenylbutan-1-ol, 5-phenylpentan-1-ol, 2-benzylheptan-1-ol, 2, 2-Dimethyl-3-phenyl-propan-1-ol, 2,2-dimethyl-3- (3'-methyl-phenyl) -propan-1-ol, 2-ethyl-3-phenylpropan-1-ol, 2-ethyl -3- (3'-methylphenyl) -propan-1-ol, 3- (3'-chlorophenyl) -2-ethyl-propan-1-ol, 3- (2'-chlorophenyl) -2-ethyl-propan-1-ol, 3- (4'-Chlorophenyl) -2-ethyl-propan-1-ol, 3- (3 ', 4'-dichlorophenyl) -2-ethyl-propan-1-ol, 2-ethyl-3- (2'-methyl-phenyl) - propan-1-ol, 2-ethyl-3- (4'-methylphenyl) -propan-1-ol, 3- (3 ', 4'-dimethylphenyl) -2-ethyl-propan-1-ol, 2-ethyl -3- (4'-methoxyphenyl) -propan-1-ol, 3- (3 ', 4'-dimethoxyphenyl) -2-ethyl-propan-1-ol, 2-allyl-3-phenyl-propan-1-ol and 2- n-Pentyl-3-phenylpropan-1-ol and mixtures thereof. Highly preferred is phenoxyethanol, as well as mixtures of 2-benzylheptan-1-ol and phenoxyethanol. Further particularly preferred compositions according to the invention comprise at least one alcohol AA-1, as described above, in a total amount of 0.05-10% by weight, preferably 0.1-1.5% by weight, more preferably 0.2-2% by weight .-%, most preferably 0.3 to 1, 5 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.

According to the invention, the cosmetic composition may furthermore comprise as further deodorant active ingredient at least one compound from the group of tropolones (I)

include, where the radicals R1 to R5 in formula (I) independently selected from - H, _-CH3, -CH2CH3, - (CH ₂₎ ₂ CH _3, -CH (CH ₃₎ 2, -OH, -OR 6 (with R6 = _-CH3, -CH2CH3, - (CH ₂₎ ₂ CH _3, - CH (CH ₃₎ _2), -COOR 7 (where R 7 = -CH _3, -CH ₂ CH _3, - (CH ₂₎ ₂ CH ₃ , -CH (CH ₃ ) ₂ ), -NO ₂ , -NH ₂ , -F, -Cl, -Br, -I.

Very particularly preferred tropolones are the alpha-tropolone and the three isomeric thujaplicins. Preferred uses according to the invention are characterized in that the or the 1,2-alkanediol (s) together with at least one compound from the group

- tropolone (R1 = R2 = R3 = R4 = R5 = H in formula (I))

- alpha-thujaplicin (R1 = - (CH (CH ₃₎ _2, R2 = R3 = R4 = R5 = H in the formula (I))

- beta-thujaplicin (R ₂ = - (CH (CH ₃ ) ₂ , R ₁ = R ₃ = R ₄ = R 5 = H in formula (I))

- gamma-thujaplicin (R3 = - (CH (CH ₃₎ _2, R1 = R2 = R4 = R5 = H are used in formula (I)).

The cosmetic composition particularly preferably contains tropolone (2-hydroxy-2,4,6-cycloheptatrienone), preferably in an amount of 0.001-0.1% by weight, based on the weight of the composition, without taking into account any propellant present ,

Further preferred agents according to the invention are characterized by a content of the deodorant active ingredient triethyl citrate. Triethyl citrate is a known deodorant active which acts as an enzyme inhibitor for esterases and lipases and thus contributes to the broad spectrum effect of agents according to the invention. Preferred agents according to the invention contain from 0.5 to 15% by weight, preferably from 3 to 8% by weight, most preferably from 4 to 7% by weight, based in each case on the weight of the composition, without taking into account any blowing agent present.

According to the invention, the cosmetic composition may further contain, as an antibacterial deodorant active ingredient, tea tree oil which is commercially available as Melalleuca Alternifolia Leaf Oil, for example as Melafresh® T96 from Southern Cross Botanicals. The amount thereof is preferably 0.01 to 0.5 wt .-%, more preferably 0.05 to 0.2 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.

Apocrine sweat is a complex mixture that includes sebum and other fats as well as steroids. Steroids themselves are not water soluble. In order to be carried away with the body fluids, they are usually present as sulfate or as glucuronide. On the Skin is the cleavage of these steroid esters in the volatile free steroids by hydrolytic enzymes of the skin bacteria, especially the coryneform bacteria. In principle all bacterial exoesterases are capable of this, but especially the enzymes arylsulfatase and beta-glucuronidase. Compounds which inhibit arylsulfatase or beta-glucuronidase therefore represent preferred deodorant active ingredients according to the invention.

The development of short- and medium-chain fatty acids, which contribute significantly to body odor, begins with the cleavage of skin lipids to branched long-chain fatty acids. Cleavage of the skin lipids, predominantly as glycerol esters, is essentially by Propionibacterium, Corynebacterium A and Staphylococcus species (AG James et al., Generation and Turnover of Volatile Fatty Acids by Axillary Bacteria, 22 ^nd IFSCC Congress, Edinburgh, 2002, Poster 108). AG James et al. further disclose that from the long-chain branched fatty acids by the hydrolytic enzymes of a particular Corynebacterium, the AG James et al. as Corynebacterium A, both short - chain C2 - Cs fatty acids and medium chain C6 - Ci2 fatty acids are formed, which are mainly responsible for the axillary body odor. In principle, all bacterial exoesterases are capable of this lipid cleavage, but especially the enzyme lipase. Compounds which inhibit lipase are therefore also preferred deodorant agents according to the invention.

Another class of compounds which also results from the bacterial decomposition of the sweat constituents and which contributes to body odor are saturated and unsaturated aldehydes, especially those with a chain length of C6-C12, in particular hexanal, heptanal, octenal and nonenal. These are formed by beta-cleavage from the hydroperoxides, which are formed by the action of the 5-lipoxygenase on unsaturated fatty acids. Compounds which inhibit the enzyme 5-lipoxygenase are therefore also preferred deodorant agents according to the invention.

Furthermore, it is known that highly foul-smelling components of human body odor and halitosis are, in particular, volatile sulfur compounds released by enzymatic reaction (so-called "volatile sulfur compounds" (VSC).) Sulfur-containing compounds come as water-soluble amino acid conjugates with sweat on the human skin They are released by enzymatic reactions from skin bacteria (especially staphylococci and corynebacteria), an enzyme that plays a key role in the release of VSCs, cystathionine beta-lyase, which cleaves VSCs from the amino acids and thus is an important cause in the development of body odor compounds which inhibit the enzyme cystathionine beta-lyase, therefore, also according to the invention are preferred deodorant agents.

Further preferred agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme arylsulfatase. According to the invention preferred Deodorant active ingredients which act as arylsulfatase inhibitors are those disclosed in US 5643559, US 5676937, WO2001 / 099376 A2, EP1430879 A1 and DE 10216368 A1. Further particularly preferred agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme arylsulfatase, in a total amount of 0.001-10 wt.%, Preferably 0.01-5 wt.%, Particularly preferably 0, 1 - 2.5 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.

Further preferred agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme beta-glucuronidase. Deodorant active ingredients which are active according to the invention and act as a beta-glucuronidase inhibitor are those disclosed in WO2003 / 039505 A2. Further particularly preferred agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme beta-glucuronidase, in a total amount of 0.001-10% by weight, preferably 0.01-5% by weight, more preferably 0, 1 - 2.5 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.

Further preferred agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme lipase. According to preferred deodorant active ingredients which act as lipase inhibitor are selected from those disclosed in EP 1428520 A2, further selected from the aminomethylenemalonic acid derivatives according to DE 3018132 A1, the ethylene oxide-propylene oxide copolymers according to GB 2335596 A1 and the salts of Phytic acid according to EP 650 720 A1. Further particularly preferred agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme lipase, in a total amount of 0.001-10 wt.%, Preferably 0.01-5 wt.%, Particularly preferably 0, 1 - 2.5 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.

Further particularly preferred agents according to the invention are characterized by a content of at least one compound which is an inhibitor of 5-lipoxygenase. Deodorant active ingredients which are preferred according to the invention and act as 5-lipoxygenase inhibitors are disclosed in EP 1428519 A2. Further particularly preferred agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme 5-lipoxygenase, in a total amount of 0.001-10% by weight, preferably 0.01-5% by weight, more preferably 0.1 - 2.5 wt .-%, each based on the weight of the composition, without taking into account any existing propellant.

Further particularly preferred agents according to the invention are characterized by a content of at least one compound that is an inhibitor of the enzyme cystathionine beta-lyase. Deodorant active ingredients which are preferred according to the invention and act as inhibitors of cystathionine beta-lyase are selected from those disclosed in EP 495918 B1, WO 2006/079934, DE 10201000046 A1, WO2010 / 031657 A1 and WO2010 / 046291 A1. Further particularly preferred agents according to the invention are characterized by a content of at least one compound which is an inhibitor of the enzyme cystathionine beta-lyase, in a total amount of 0.001-10% by weight, preferably 0.01-5% by weight, particularly preferably 0.1-2.5% by weight, based in each case on the weight of the composition, of any propellant which may be present.

Further inventively preferred deodorant active ingredients are odor absorbers, deodorizing ion exchangers, antimicrobial agents, prebiotic components and enzyme inhibitors or, more preferably, combinations of said active ingredients.

Silicates serve as odor absorbers, which at the same time advantageously support the rheological properties of the composition according to the invention. Among the silicates particularly preferred according to the invention are, in particular, phyllosilicates and, among these, in particular montmorillonite, kaolinite, mit, beidellite, nontronite, saponite, hectorite, bentonite, smectite and talcum. Other preferred odor absorbers are, for example, zeolites, Zinkricinoleat, cyclodextrins, certain metal oxides, such as. As alumina, and chlorophyll. They are preferably in a total amount of 0.1 to 10 wt .-%, more preferably 0.5 to 7 wt .-% and most preferably 1-5 wt .-%, each based on the total composition without propellant, included.

According to the invention, germ-inhibiting or antimicrobial active ingredients are understood as meaning those active substances which reduce the number of skin germs participating in the formation of the odor or inhibit their growth. These organisms include, among others, various species from the group of staphylococci, the group of Corynebacteria, anaerococci and micrococci.

As germ-inhibiting or antimicrobial agents according to the invention are particularly preferred organohalogen compounds and halides and a number of plant extracts and. These include u. a. Triclosan, chlorhexidine and 3,4,4'-trichlorocarbanilide, bromochlorophene, dichlorophen, chlorothymol, chloroxylenol, hexachlorophene, dichloro-m-xylenol. Furthermore, phenol, terpene alcohols such. As farnesol and chlorophyllin copper complexes preferred deodorant agents.

Preferred deodorant compositions according to the invention contain as further constituent at least one deodorant active ingredient which is selected from aromatic alcohols of structure AA-1 with the abovementioned substituents, preferably phenoxyethanol, 1,2-alkanediols having 5 to 7 carbon atoms, tropolone, triethyl citrate and Mixtures thereof.

Antioxidant substances can counteract the oxidative decomposition of the welding components and in this way inhibit odor development. Preferred antioxidants are imidazole and Imidazole derivatives (eg, urocanic acid), peptides, such as. B. D, L-carnosine, D-carnosine, L-carnosine and their derivatives (eg., Anserin), carotenoids, carotenes (eg, α-carotene, ß-carotene, lycopene) and their derivatives, lipoic acid and their derivatives (eg dihydrolipoic acid), aurothioglucose, propylthiouracil and other thio compounds (eg thioglycerol, thiosorbitol, thioglycolic acid, thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl , Propyl, amyl, butyl, lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids , Nucleotides, nucleosides and salts) as well as sulfoximine compounds (eg buthionine sulfoximines, homocysteine sulfoximine, buthionine sulfones, penta-, hexa-, heptathionine sulfoximine) in very low tolerated dosages (eg pmol / kg to μΐηοΙ / kg), furthermore Metal chelators (eg, α-hydroxy fatty acids, EDTA, EGTA, lactofe rrin), humic acids, bile acids, bile extracts, catechins, bilirubin, biliverdin and their derivatives, unsaturated fatty acids and their derivatives (eg. Gamma-linolenic acid, linoleic acid, arachidonic acid, oleic acid), folic acid and its derivatives, hydroquinone and its derivatives (eg arbutin), ubiquinone and ubiquinol and their derivatives, vitamin C and its derivatives (eg ascorbyl palmitate, stearate, dipalmitate, acetate, magnesium ascorbyl phosphates, sodium and magnesium ascorbate, disodium ascorbyl phosphate and sulfate, potassium ascorbyl tocopheryl phosphate, chitosan ascorbate), isoascorbic acid and its derivatives, tocopherols and their derivatives (for example tocopheryl acetate, linoleate, oleate and succinate, tocophereth-5, tocophereth-10, tocophereth-12, tocophereth-18, tocophereth-50, tocopherolan), vitamin A and derivatives (e.g., vitamin A palmitate), the benzylic resin coniferyl benzoate, rutin, rutinic acid, and their derivatives, disodiumtrininyldisulphate, cinnamic acid and its derivatives, kojic acid, chitosan glycolate and salicylate, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiacetic acid, nordihydroguiaretic acid, trihydroxybutyrophenone, urine and their derivatives, mannose and their derivatives, selenium and selenium derivatives (eg. Selenium methionine), stilbenes and stilbene derivatives (eg, stilbene oxide, trans-stilbene oxide). According to the invention, suitable derivatives (salts, esters, sugars, nucleotides, nucleosides, peptides and lipids) and mixtures of these active substances mentioned or anhydrous extra-kte plants which contain these antioxidants can be used.

Preferred lipophilic, oil-soluble antioxidants from this group are tocopherol and its derivatives, in particular tocopheryl acetate (vinylamine acetate), and carotenoids, as well as butylhydroxytoluene and butylhydroxyanisole.

Preferred compositions according to the invention which are in the form of an emulsion or suspension preferably also contain at least one liquid under normal conditions, which is not a fragrance and is not an essential oil.

The cosmetic oil is liquid under normal conditions. Essential oils according to the invention are understood to mean mixtures of volatile components which are prepared by steam distillation from vegetable raw materials, such as. B. citrus oils. Particularly preferred deodorant or antiperspirant compositions according to the invention also contain at least one perfume. The definition of a fragrance in the sense of the present application is in accordance with the expert definition as it can be found in the RÖMPP Chemie Lexikon, as of December 2007. Thereafter, a fragrance is a chemical compound with odor and / or taste that excites the hair cell receptors of the olfactory system (adequate stimulus). The necessary physical and chemical properties are a low molecular weight of at most 300 g / mol, a high vapor pressure, minimal water and high lipid solubility and weak polarity and the presence of at least one osmophoric group in the molecule. To delineate volatile, low molecular weight substances, which are usually and also for the purposes of the present application not as a fragrance, but primarily as a solvent and used, such as ethanol, propanol, isopropanol and acetone, of fragrances according to the invention, fragrances according to the invention have a molecular weight from 74 to 300 g / mol, contain at least one osmophoric group in the molecule and have an odor and / or taste, that is, they excite the hair cell receptors of the olfactory system.

As perfumes, perfumes, perfume oils or perfume oil ingredients can be used. Perfume oils or fragrances can according to the invention individual fragrance compounds, eg. As the synthetic products of the ester type, ethers, aldehydes, ketones, alcohols and hydrocarbons. Fragrance compounds of the ester type are known e.g. Benzyl acetate, phenoxyethyl isobutyrate, p-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinylacetate (DMBCA), phenylethylacetate, benzylacetate, ethylmethylphenylglycinate, allylcyclohexylpropionate, styrallylpropionate, benzylsalicylate, cyclohexylsalicylate, floramate, melusate and jasmecyclate. The ethers include, for example, benzyl ethyl ether and ambroxane, to the aldehydes e.g. the linear alkanals of 8 - 18 C atoms, citral, citronellal, citronellyloxy-acetaldehyde, cyclamen aldehyde, lilial and bourgeonal, to the ketones e.g. the ionones, alpha-lsomethylionone and methylcedryl ketone, the alcohols anethole, citronellol, eugenol, geraniol, linalool, phenylethyl alcohol and terpineol, the hydrocarbons mainly include the terpenes such as limonene and pinene. Preferably, however, mixtures of different fragrances are used, which together produce an attractive fragrance.

Particularly preferred deodorant or antiperspirant compositions according to the invention contain at least one perfume in a total amount of 0.00001 to 10 wt .-%, preferably 0.5 to 7 wt .-%, most preferably 1-6 wt .-%, each based on the total weight of the agent, without taking into account any existing propellant. Table overview

The composition of some preferred cosmetic agents can be found in the following tables (figures in% by weight based on the total weight of the cosmetic composition, if not stated otherwise, without taking into account any possibly used propellant).

0.2 to 1, 0 wt .-% in the cosmetic composition, further preferably 0.3 to 0.5 wt .-%.

Formula 1 1 b Formula 12b Formula 13b Formula 14b Formula

15b

Water 0.1 to 5.0 0.5 to 5.0 1, 0 to 4.5 1, 5 to 4.0 2.5 to 4.0

1, 2-octanediol 0.05 to 3.0 0.1 to 2.0 0.15 to 0.2 to 0.7 0.2 to 0.5

1, 0

Ethylhexylglycerol 0.05 to 2.0, 1 to 1.5, 0.2 to 1.0, 0.3 to 0.7 0.3 to 0.5

Triethyl citrate 0.5 to 15.0 1, 0 to 10.0 2.0 to 8.0 3.0 to 8.0 4.0 to 7.0

Mise add 100 add 100 add 100 add 100 add 100 Formula 11c Formula 12c Formula 13c Formula 14c Formula

15c

Water 0.1 to 5.0 0.5 to 5.0 1.0 to 4.5 1.5 to 4.0 2.5 to 4.0

1,2-alkanediol ester with 8 0.05 to 1.0 0.1 to 1.0 0.1 to 0.5 0.2 to 0.4 0.2 to 0.3 to 30 carbon atoms

1,2-Alkandiolether with 8 0.05 to 2.0 0.1 to 1.5 0.2 to 1.0 0.3 to 0.7 0.3 to 0.5 to 30 carbon atoms

Triethyl citrate 0.5 to 15.0 1.0 to 10.0 2.0 to 8.0 3.0 to 8.0 4.0 to 7.0

Mise add 100 add 100 add 100 add 100 add 100

Formula 11h Formula 12h Formula 13h Formula 14h Formula

15h

Water 0.1 to 5.0 0.5 to 5.0 1.0 to 4.5 1.5 to 4.0 2.5 to 4.0

1,2-octanediol 0.05 to 3.0 0.1 to 2.0 0.15 to 0.2 to 0.7 0.2 to 0.5

1.0

Ethylhexylglycerol 0.05 to 2.0 0.1 to 1.5 0.2 to 1.0 0.3 to 0.7 0.3 to 0.5

Triglyceryl acrylate, 0.05 to 1.0 0.1 to 1.0 0.1 to 0.5 0.2 to 0.4 0.2 to 0.3 diglyceryl acrylate

and / or glycerol acrylate

Triethyl citrate 0.5 to 15.0 1.0 to 10.0 2.0 to 8.0 3.0 to 8.0 4.0 to 7.0

Mise add 100 add 100 add 100 add 100 add 100

Formula 21b Formula 22b Formula 23b Formula 24b Formula

25b

Water 0.1 to 5.0 0.5 to 5.0 1.0 to 4.5 1.5 to 4.0 2.5 to 4.0

1,2-octanediol 0.05 to 3.0 0.1 to 2.0 0.15 to 0.2 to 0.7 0.2 to 0.5

1.0

Ethylhexylglycerol 0.05 to 2.0 0.1 to 1.5 0.2 to 1.0 0.3 to 0.7 0.3 to 0.5

Triethyl citrate 0.5 to 15.0 1.0 to 10.0 2.0 to 8.0 3.0 to 8.0 4.0 to 7.0

Phenoxyethanol 0.05 to 10.0 0.1 to 5.0 0.2 to 3.0 0.3 to 2.0 0.5 to 1.5

Mise add 100 add 100 add 100 add 100 add 100 Formula 21c Formula 22c Formula 23c Formula 24c Formula

25c

Water 0.1 to 5.0 0.5 to 5.0 1.0 to 4.5 1.5 to 4.0 2.5 to 4.0

Triethyl citrate 0.5 to 15.0 1.0 to 10.0 2.0 to 8.0 3.0 to 8.0 4.0 to 7.0

Phenoxyethanol 0.05 to 10.0 0.1 to 5.0 0.2 to 3.0 0.3 to 2.0 0.5 to 1.5

Mise add 100 add 100 add 100 add 100 add 100

Formula 21f Formula 22f Formula 23f Formula 24f Formula 25f

Water 0.1 to 5.0 0.5 to 5.0 1.0 to 4.5 1.5 to 4.0 2.5 to 4.0

2-methyl-5- 0.05 to 1.0 0.1 to 1.0 0.2 to 0.8 0.3 to 0.7 0.4 to 0.6 cyclohexylpentanol

Ethylhexylglycerol 0.05 to 2.0 0.1 to 1.5 0.2 to 1.0 0.3 to 0.7 0.3 to 0.5

Triethyl citrate 0.5 to 15.0 1.0 to 10.0 2.0 to 8.0 3.0 to 8.0 4.0 to 7.0

Phenoxyethanol 0.05 to 10.0 0.1 to 5.0 0.2 to 3.0 0.3 to 2.0 0.5 to 1.5

Mise add 100 add 100 add 100 add 100 add 100

Mise add 100 add 100 add 100 add 100 add 100

Mise add 100 add 100 add 100 add 100 add 100

Mise add 100 add 100 add 100 add 100 add 100

Mise add 100 add 100 add 100 add 100 add 100

According to the invention, "Mise" is to be understood as meaning ethanol as a cosmetic carrier, and possibly further customary constituents of deodorants.

EXEMPLARY EMBODIMENTS

The following formulation examples are intended to illustrate the subject matter of the invention without limiting it thereto.

The cosmetic compositions described below in the table were prepared. The compositions 1 to 6 were in this case in a weight ratio of 1: 3 with the propellant propane / butane (15/85) in epoxy-coated aluminum cans (varnish: PPG7940) filled with valve plate made of tinplate.

Sprayable deodorants (in% by weight)

Results:

All formulations 1 to 6 had an electrical conductivity of <50 μ8 / ηη. Conductivity did not increase over several weeks. Corrosion of the metallic surface / components of the container was not observed.

Claims

1. Deodorant cosmetic agent in a container which has at least one metallic surface area in contact with the cosmetic agent during storage or dosage of the cosmetic agent and / or at least one metallic component in contact with the cosmetic agent, wherein the cosmetic agent contains:

0.1 to 5.0% by weight of water,

- ethanol

2. A cosmetic composition according to claim 1, wherein the container is a metal aerosol spray container.

A cosmetic composition according to claim 1 or 2, wherein the aliphatic alcohol compounds are selected from the group consisting of a saturated aliphatic compound having one or more 1,2-alkanediol group (s) and a monohydric alcohol.

4. A cosmetic composition according to any one of the preceding claims, wherein the compound having one or more 1, 2-alkanediol group (s) a linear or branched 1, 2-alkanediol having 8 to 12 carbon atoms, a linear or branched 1, 2-alkane diol ethers 8 to 30 carbon atoms and / or a linear or branched 1, 2-alkanediol ester having 8 to 30 carbon atoms.

5. Cosmetic composition according to one of the preceding claims, wherein the 1, 2-alkane diol 1, 2-octanediol and / or 1, 2-decanediol.

6. A cosmetic composition according to any one of the preceding claims, wherein the 1, 2-alkane diol is an a-monoalkyl glycerol ether having a branched or linear saturated or unsaturated C8-C22 alkyl radical, preferably α - (2-ethylhexyl) glycerol ether.

7. Cosmetic composition according to one of the preceding claims, wherein the 1, 2-alkanediol ester is a carboxylic acid ester of mono-, di- and / or triglycerol, preferably glycerol monocaprylates, glycerol dicaprylates and / or glycerol tricaprylates.

8. Cosmetic composition according to one of the preceding claims, wherein the monohydric alcohol is a linear or branched alcohol having 8 to 30 carbon atoms and a terminal OH Group which preferably has an alicyclic ring.

A cosmetic composition according to claim 8, wherein the monohydric alcohol is 2-methyl-5-cyclohexylpentanol.

1 1. Use of a cosmetic composition comprising 0, 1 to 5.0 wt .-% water, ethanol and 0.1 to 5.0 wt .-% of at least two different nonionic saturated aliphatic alcohol compounds having 8 or more carbon atoms as deodorant Containing active ingredients, and which has an electrical conductivity of 50 μβ / ϋΐη or less, as contents of a container such that upon storage or dosage of the cosmetic at least one metallic surface area and / or at least one metallic component of the container with the cosmetic in contact stands.