WO2016014864A8 - Hydroxy-(r),(r)-2,2'-bismethylnaltrexones and uses thereof - Google Patents
Hydroxy-(r),(r)-2,2'-bismethylnaltrexones and uses thereof Download PDFInfo
- Publication number
- WO2016014864A8 WO2016014864A8 PCT/US2015/041848 US2015041848W WO2016014864A8 WO 2016014864 A8 WO2016014864 A8 WO 2016014864A8 US 2015041848 W US2015041848 W US 2015041848W WO 2016014864 A8 WO2016014864 A8 WO 2016014864A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydroxy
- bismethylnaltrexones
- synthesis
- methods
- well
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present application relates to compounds of Formula (I): wherein R1 and X are as defined herein, as well as methods for synthesis and use thereof. The present application also relates to 10'-hydroxy-(R),(R)-2,2'-bismethylnaltrexone, as well as methods for synthesis and use thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462027852P | 2014-07-23 | 2014-07-23 | |
| US62/027,852 | 2014-07-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2016014864A1 WO2016014864A1 (en) | 2016-01-28 |
| WO2016014864A8 true WO2016014864A8 (en) | 2016-03-24 |
Family
ID=55163804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2015/041848 WO2016014864A1 (en) | 2014-07-23 | 2015-07-23 | Hydroxy-(r)-2,2'-bismethylnal trexones and uses thereof |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2016014864A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10807995B2 (en) | 2018-07-13 | 2020-10-20 | Alkermes Pharma Ireland Limited | Thienothiophene compounds for long-acting injectable compositions and related methods |
| WO2020012248A1 (en) | 2018-07-13 | 2020-01-16 | Alkermes Pharma Ireland Limited | Novel naphthylenyl compounds for long-acting injectable compositions and related methods |
| WO2020094634A1 (en) | 2018-11-05 | 2020-05-14 | Alkermes Pharma Ireland Limited | Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008233129B2 (en) * | 2007-03-29 | 2014-03-20 | Progenics Pharmaceuticals, Inc. | Peripheral opioid receptor antagonists and uses thereof |
| WO2009099411A1 (en) * | 2008-02-06 | 2009-08-13 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
-
2015
- 2015-07-23 WO PCT/US2015/041848 patent/WO2016014864A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016014864A1 (en) | 2016-01-28 |
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