+

WO2016002363A1 - Dispositif de mesure - Google Patents

Dispositif de mesure Download PDF

Info

Publication number
WO2016002363A1
WO2016002363A1 PCT/JP2015/064072 JP2015064072W WO2016002363A1 WO 2016002363 A1 WO2016002363 A1 WO 2016002363A1 JP 2015064072 W JP2015064072 W JP 2015064072W WO 2016002363 A1 WO2016002363 A1 WO 2016002363A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
housing
wavelength
translucent member
opening
Prior art date
Application number
PCT/JP2015/064072
Other languages
English (en)
Japanese (ja)
Inventor
西村　望
勉 篠崎
敏晶 深井
右一 佐藤
悠平 福島
Original Assignee
日本電気株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日本電気株式会社 filed Critical 日本電気株式会社
Priority to JP2016531180A priority Critical patent/JPWO2016002363A1/ja
Publication of WO2016002363A1 publication Critical patent/WO2016002363A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light

Definitions

  • the present invention relates to a measuring apparatus that detects specific components using light.
  • Patent Document 1 discloses an apparatus for measuring a blood sugar level in blood.
  • a light source, a light receiving element, and a waveguide are provided on the upper surface of the base portion. Then, a part of the waveguide is exposed on the lower surface of the base part, the light generated by the light source is irradiated from the part, and the reflected light is received and guided to the light receiving element.
  • Patent Document 2 describes that light is irradiated in an oblique direction with respect to the surface of the skin, and a plurality of light receiving portions are arranged obliquely and spaced apart.
  • the technique described in Patent Document 2 is intended to measure glucose contained in skin and blood.
  • Patent Document 3 it is described that light is irradiated in an oblique direction with respect to the surface of the skin, and the light receiving portion is disposed obliquely.
  • a patch is applied to the skin. Then, for example, the amount of glucose in the dermis layer is measured by pressing a measuring device against this patch.
  • the light-shielding plate is arrange
  • An object of the present invention is to control the depth of a measurement site with high accuracy and to prevent light from a light source from entering a light receiving element without passing through a measurement target such as skin.
  • a housing An opening provided in a part of the housing; A translucent member that is located within the opening and constitutes part of the housing, and transmits light of a first wavelength; A light emitting means that is disposed inside the housing and emits light including a first wavelength obliquely to the light transmitting member with respect to an outer surface of the light transmitting member; A light detecting means disposed inside the housing, facing the light transmissive member, and detecting light of the first wavelength; A partition member disposed inside the housing, located between the light emitting means and the light detecting means, and a part of the partition member in contact with the housing; A measuring device is provided.
  • the depth of the measurement site can be controlled with high accuracy, and the light from the light source can be prevented from entering the light receiving element without passing through the measurement target such as the skin.
  • each component of the measuring apparatus 10 is not a hardware unit configuration but a functional unit block.
  • the control unit 150 and the calculation unit 160 are arbitrary CPUs, memories, programs loaded in the memory, storage media such as a hard disk for storing the programs, and network and network interface interfaces. Realized by a combination of There are various modifications of the implementation method and apparatus.
  • FIG. 1 is a diagram illustrating a configuration of a measurement apparatus 10 according to the first embodiment.
  • the measuring apparatus 10 includes a housing 100, a translucent member 110, a light emitting unit 120, a partition member 130, and a light detecting unit 140.
  • the housing 100 is provided with an opening 102.
  • the translucent member 110 is located in the opening 102 and transmits light of the first wavelength.
  • the light emitting unit 120 and the light detection unit 140 are disposed inside the housing 100.
  • the light emitting unit 120 irradiates (emits) light including the first wavelength toward the translucent member 110 and radiates the light obliquely with respect to the outer surface of the translucent member 110.
  • the light detection unit 140 is disposed toward the translucent member 110 and detects light having the first wavelength.
  • the optical axis of the light detection unit 140 passes through the translucent member 110 and detects the intensity of the first wavelength light.
  • the optical axis of the light detection unit 140 is defined as a line that passes through the center of the light receiving surface of the light detection unit 140 and is perpendicular to the light receiving surface of the light detection unit 140, for example.
  • the partition member 130 is disposed inside the housing 100 and is located between the light emitting unit 120 and the light detection unit 140. A part of the partition member 130 is in contact with the housing 100. Details will be described below.
  • the measuring device 10 is a device that measures a sugar content (for example, glucose) contained in an interstitial fluid of living skin, for example, dermal tissue.
  • the first wavelength is in the near infrared region (for example, 1200 nm or more and 3000 nm or less).
  • the measuring apparatus 10 is used in the state which pressed the translucent member 110 on skin.
  • the housing 100 is formed using, for example, resin or metal.
  • An opening 102 is provided on one surface of the housing 100.
  • the housing 100 may be composed of a plurality of parts.
  • the opening 102 is blocked by the translucent member 110.
  • a part of the housing 100 is constituted by the translucent member 110.
  • the translucent member 110 is a plate-like member made of, for example, glass or resin, and transmits light having the first wavelength.
  • the translucent member 110 is not deformed when pressed against the measurement site.
  • the translucent member 110 also has a function of extending the wrinkles at the measurement site.
  • the translucent member 110 may be a flat plate or may be slightly curved.
  • the housing 100 may be configured by a plurality of members.
  • the light emitting unit 120 has a light emitting element such as an LED or a laser diode as a light source. This light source preferably emits light of the first wavelength stronger than light of other wavelengths.
  • the optical axis of the light emitting unit 120 is disposed obliquely with respect to the outer surface of the translucent member 110. For this reason, when the translucent member 110 of the housing
  • the light detection unit 140 has a photoelectric conversion element such as a photodiode. This photoelectric conversion element preferably has higher sensitivity to light of the first wavelength than sensitivity of light of other wavelengths.
  • the light receiving surface of the light detection unit 140 is disposed obliquely with respect to the outer surface of the translucent member 110.
  • the optical axis of the light detection unit 140 is disposed obliquely with respect to the outer surface of the translucent member 110, and intersects the optical axis of the light emitting unit 120 outside the translucent member 110.
  • the distance d between the intersection ⁇ of the two optical axes and the outer surface of the translucent member 110 is 2 mm or less, preferably 1.5 mm or less.
  • interval d is 0.5 mm or more.
  • the angle ⁇ formed by the two optical axes is, for example, 60 ° or more and 120 ° or less.
  • the angle formed by the optical axis of the light emitting unit 120 with respect to the outer surface of the light transmissive member 110 and the angle formed by the optical axis of the light detecting unit 140 with respect to the outer surface of the light transmissive member 110 are preferably equal to each other.
  • the partition member 130 is disposed in the measuring apparatus 10 and is located between the light emitting unit 120 and the light detecting unit 140. A part of the partition member 130 is in contact with the housing 100, specifically, the translucent member 110. The portion of the translucent member 110 that is in contact with the partition member 130 is a portion of the translucent member 110 that intersects the optical axis of the light emitting unit 120 and a portion of the translucent member 110 that intersects the optical axis of the light detecting unit 140. Located between. Moreover, the partition member 130 is configured not to transmit light having the first wavelength. For this reason, it can suppress that the light which the light emission part 120 light-emitted enters into the light detection part 140, without passing through the exterior of the housing
  • the shape of the partition member 130 is a triangular prism.
  • One of the sides of the triangular prism is in contact with the translucent member 110.
  • one of the two surfaces constituting the side is directed in the direction along the optical axis of the light emitting unit 120, and the other surface is directed in the direction along the optical axis of the light detection unit 140. ing.
  • these surfaces may or may not be parallel to the optical axis.
  • the remaining one of the side surfaces of the partition member 130 is supported by another member (not shown).
  • Other members for example, a holding member that holds the light emitting unit 120 and the light detecting unit 140
  • the partition member 130 may be integrally formed.
  • the side of the partition member 130 that is in contact with the translucent member 110 may be chamfered.
  • the translucent member 110 is pressed against the skin of the living body.
  • the light emitting unit 120 emits light.
  • the light emitted from the light emitting unit 120 enters at least the dermis tissue of the skin and is scattered by the cell wall or the like.
  • the light detection unit 140 detects a part of the scattered light.
  • a part of this light is absorbed by a specific component in the skin, for example, sugar such as glucose contained in the interstitial fluid. . Therefore, the concentration of a specific component in the skin can be calculated based on the light intensity detected by the light detection unit 140.
  • the epidermis contains glucose, but this glucose concentration is difficult to follow the glucose concentration in the blood.
  • the subcutaneous tissue is mainly composed of adipose tissue, the glucose concentration is low. For this reason, the light from the light emitting unit 120 needs to be scattered at an appropriate depth after entering the skin.
  • the intersection ⁇ between the optical axis of the light emitting unit 120 and the optical axis of the light detecting unit 140 is always from the surface of the skin. Located at depth d. d is 2 mm or less, preferably 1.5 mm or less. For this reason, the light detected by the light detection unit 140 includes many components scattered at an appropriate depth in the skin. Therefore, when the concentration of a specific component in the skin is calculated based on the light intensity detected by the light detection unit 140, the reliability of the calculation result is improved.
  • a partition member 130 is located between the light emitting unit 120 and the light detecting unit 140.
  • a part of the partition member 130 is in contact with the housing 100 (for example, the translucent member 110). For this reason, it can suppress that the light which the light emission part 120 light-emitted enters into the light detection part 140, without passing through the exterior of the housing
  • FIG. Therefore, when the concentration of a specific component in the skin is calculated based on the light intensity detected by the light detection unit 140, the reliability of the calculation result is further improved.
  • FIG. 2 is a diagram illustrating a configuration of the measurement apparatus 10 according to the second embodiment.
  • the measurement apparatus 10 according to the present embodiment has the same configuration as the measurement apparatus 10 according to the first embodiment except for the following points.
  • the housing 100 has a first opening 102 a and a second opening 102 b as the opening 102.
  • a first translucent member 112 is fitted in the first opening 102a
  • a second translucent member 114 is fitted in the second opening 102b.
  • the optical axis of the light emitting unit 120 extends to the outside of the housing 100 via the first light transmissive member 112, and the optical axis of the light detecting unit 140 is external to the housing 100 via the second light transmissive member 114. It extends to.
  • the partition member 130 is in contact with a portion of the housing 100 located between the first opening 102a and the second opening 102b.
  • the light emitting unit 120 has a light source 122 and a lens 124.
  • the light source 122 has the light emitting element shown in the first embodiment.
  • the lens 124 condenses the light from the light source 122.
  • a condensing point of light from the light source 122 by the lens 124 is located outside the translucent member 110.
  • the distance of this condensing point and the outer surface of the translucent member 110 is 2 mm or less, Preferably it is 1.5 mm or less, and Preferably it is 0.5 mm or more.
  • this condensing point may overlap with the optical axis of the light detection unit 140. However, when the distance between the above-described condensing point and the outer surface of the translucent member 110 is greater than 2 mm, the optical axis of the light detection unit 140 does not overlap the above-described condensing point.
  • the measuring apparatus 10 includes a control unit 150, a calculation unit 160, a display unit 170, and an input unit 180.
  • the input unit 180 is operated by the user of the measuring apparatus 10.
  • the input unit 180 is, for example, a push type or contact type switch, and is located on the outer surface of the housing 100.
  • the control unit 150 causes the light emitting unit 120 to emit light when input is made to the input unit 180.
  • the calculation unit 160 calculates the amount or concentration of the specific component in the detection target, for example, the amount or concentration of sugar (for example, glucose) contained in the interstitial fluid of the skin, according to the detection result of the light detection unit 140. Then, the calculation unit 160 causes the display unit 170 to display the calculated result. Since the display unit 170 is located on the outer surface of the housing 100, the user of the measurement apparatus 10 can recognize the measurement result obtained by the measurement apparatus 10 by viewing the display unit 170.
  • sugar for example, glucose
  • the translucent member 110 is divided into two parts, a first translucent member 112 and a second translucent member 114, and the partition member 130 is provided between the first translucent member 112 and the second translucent member 114 in the housing 100. It is made to contact the part located in. For this reason, it can also suppress that the light from the light emission part 120 injects into the light detection part 140 by making the translucent member 110 into a light guide path.
  • the distance between the condensing point of the light from the light source 122 by the lens 124 and the outer surface of the translucent member 110 is 2 mm or less, preferably 1.5 mm or less. For this reason, the intensity
  • partition member 130 may be formed integrally with the housing 100.
  • FIG. 3 is a diagram illustrating a configuration of the measurement apparatus 10 according to the third embodiment.
  • the measuring apparatus 10 according to the present embodiment has the same configuration as the measuring apparatus 10 according to the first embodiment or the second embodiment except that the wavelength filter 190 is provided.
  • FIG. 3 shows a case similar to that of the second embodiment.
  • the wavelength filter 190 is disposed in front of the light detection unit 140, transmits light of the first wavelength, and cuts light of other wavelengths. Thereby, light other than the first wavelength is cut from the light incident on the light detection unit 140.
  • the wavelength filter 190 may be arranged in front of the light emitting unit 120 instead of in front of the light detecting unit 140.
  • the wavelength filter 190 may be disposed in front of the light detection unit 140 and in front of the wavelength filter 190, respectively.
  • the same effects as those in the first or second embodiment can be obtained.
  • the measurement accuracy by the measurement apparatus 10 is further improved.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne un dispositif de mesure (10) qui est pourvu d'un boîtier (100), d'un élément de transmission de lumière (110), d'une section d'émission de lumière (120), d'un élément de séparation (130) et d'une section de détection optique (140). Le boîtier (100) est pourvu d'une ouverture (102). L'élément de transmission de lumière (110) est positionné dans l'ouverture (102) et transmet la lumière ayant une première longueur d'onde. La section d'émission de lumière (120) et la section de détection optique (140) sont disposées dans le boîtier (100). La section d'émission de lumière (120) émet une lumière, comprenant la lumière ayant la première longueur d'onde, vers l'élément de transmission de lumière (110), ladite section d'émission de lumière émettant la lumière en diagonale par rapport à une surface extérieure de l'élément de transmission de lumière (110). La section de détection de lumière (140) est disposée dans la direction dans laquelle son axe optique passe à travers l'élément de transmission de lumière (110) et mesure l'intensité de la lumière ayant la première longueur d'onde. L'élément de séparation (130) est disposé dans le boîtier (100), ledit élément de séparation étant positionné entre la section d'émission de lumière (120) et la section de détection optique (140). Une partie de l'élément de séparation (130) est en contact avec le boîtier (100).
PCT/JP2015/064072 2014-07-03 2015-05-15 Dispositif de mesure WO2016002363A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2016531180A JPWO2016002363A1 (ja) 2014-07-03 2015-05-15 測定装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014-138027 2014-07-03
JP2014138027 2014-07-03

Publications (1)

Publication Number Publication Date
WO2016002363A1 true WO2016002363A1 (fr) 2016-01-07

Family

ID=55018918

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2015/064072 WO2016002363A1 (fr) 2014-07-03 2015-05-15 Dispositif de mesure

Country Status (2)

Country Link
JP (1) JPWO2016002363A1 (fr)
WO (1) WO2016002363A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008154873A (ja) * 2006-12-25 2008-07-10 Sanyo Electric Co Ltd 光学測定装置
WO2014054488A1 (fr) * 2012-10-01 2014-04-10 国立大学法人香川大学 Dispositif de mesure de caractéristique spectrale

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008154873A (ja) * 2006-12-25 2008-07-10 Sanyo Electric Co Ltd 光学測定装置
WO2014054488A1 (fr) * 2012-10-01 2014-04-10 国立大学法人香川大学 Dispositif de mesure de caractéristique spectrale

Also Published As

Publication number Publication date
JPWO2016002363A1 (ja) 2017-04-27

Similar Documents

Publication Publication Date Title
US10799128B2 (en) Optical vital signs sensor
JP5031894B2 (ja) 自発光型センサ装置
EP1924196A2 (fr) Dispositif de caractérisation optique de la peau
JP6630738B2 (ja) 生体機能検知用センサー
US10088363B2 (en) Biometric sensor and biometric analysis system including the same
US9329124B2 (en) Scattered light measurement apparatus
CN109199401A (zh) 检测装置及生物体信息测量装置
JP2009106373A (ja) 生体表層組織用センシング装置
WO2016002356A1 (fr) Dispositif de mesure
WO2016002363A1 (fr) Dispositif de mesure
JP5332713B2 (ja) 光センサーおよび計測システム
WO2016092885A1 (fr) Sonde de mesure et système de mesure optique d'organisme vivant
WO2007056971A3 (fr) Dispositif de determination de variables physiologiques
JP6705593B2 (ja) 測定装置
US20150327773A1 (en) Probe
US11331011B2 (en) System for the transcutaneous determining of blood alcohol concentration
US20240315612A1 (en) Measuring device
JP7009429B2 (ja) 血中酸素飽和度測定装置
JP7411349B2 (ja) グルコース測定装置およびグルコース測定方法
JP6946707B2 (ja) 検出装置および生体情報測定装置
US20200163601A1 (en) Optoelectronic sensor
JP2016174766A (ja) 非接触生体情報センサ
WO2015019392A1 (fr) Détecteur d'informations et dispositif de mesure d'informations, et procédé de détection d'informations
JP2017018483A (ja) 医療用プローブ
JP5060268B2 (ja) 生体計測装置および校正治具

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15815613

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2016531180

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15815613

Country of ref document: EP

Kind code of ref document: A1

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载