WO2015043030A1

WO2015043030A1 - Multi-detection position photoelectric detection device

Info

Publication number: WO2015043030A1
Application number: PCT/CN2013/085728
Authority: WO
Inventors: 张陆军; 朱建波; 曹宁; 周强; 徐新
Original assignee: 江苏英诺华医疗技术有限公司
Priority date: 2013-09-30
Filing date: 2013-10-22
Publication date: 2015-04-02
Also published as: CN203595662U

Abstract

A multi-detection position photoelectric detection device. The device comprises detection units and a light source (5), wherein each detection unit comprises a detector port (1), a transmission light inlet (2), a scattered light inlet (3) and a detection position (6); and the light source (5) is connected to one or more detection units through the transmission light inlet (2) or the scattered light inlet (3). The device also comprises one or more monochromators (4), wherein one end of each monochromator (4) is connected to the light source (5), and the other end thereof can be connected to one or more detection units. The bottom of each detection position (6) is sealed, and the top thereof has an opening; and the detector port (1), the transmission light inlet (2) and the scattered light inlet (3) are respectively mounted on the side surfaces of each detection position (6), wherein the transmission light inlet (2) and the detector port (1) are mounted in opposite positions, and the scattered light inlet (3) is mounted on another side surface. The device is a multi-detection position device which is formed by combining a plurality of same detection positions (6) together, each detection position is irradiated with a multi-angle and multi-wavelength light source. The device can enable an instrument using same to achieve the effects of faster detection, more detection manners and item types and better performance and sensitivity.

Description

Photodetection device with multiple detection bits

The utility model belongs to the field of clinical medical examination, and particularly relates to a photoelectric detecting device with multiple detection positions of biochemical, coagulation function and specific protein detecting function, wherein each detecting position of the device has a multi-angle, multi-wavelength light source and at least one Detector.

BACKGROUND OF THE INVENTION Biochemical analyzers and blood coagulation analyzers are two kinds of testing instruments commonly used in clinical laboratories. Due to different detection principles, different working processes, and different structures, the functions are different. Currently, general testing instruments perform biochemical or Coagulation function tests are performed on biochemical or hemagglutination analyzers, respectively. Specific protein detection is also a common analytical instrument for medical clinics. Although some test items (mainly some specific proteins such as immunoturbidimetry) can be performed on general biochemical analyzers, the quality of the test results is linear and far-reaching. It is better to use a specific protein instrument. Therefore, at present, all kinds of medical and scientific research institutions need to carry out these types of tests.

The biochemical analysis test is based on the principle of Rambobeel's law to detect the amount of light absorbed by a specific wavelength (corresponding to the absorption peak of the analyte) when the transmitted light of a specific wavelength passes through the sample to be tested. The content in the test sample is obtained by comparison with the known standard test result. Therefore, the detected optical signal is transmitted light of multiple wavelengths. When visible light is transmitted (irradiated) in a liquid, it will produce scattered light when it encounters particles or solid or semi-solid materials. The intensity of the scattered light is related to the size, quantity and wavelength of the object (particle) being irradiated, and also to the incident light. Strength, angle related. Hemagglutination analyzers and specific protein analyzers mainly use scattered light for detection. The coagulation function test can detect the determination and determination of various blood coagulation function indexes of plasma from the time when the blood coagulation function detecting reagent is added to the time when the liquid plasma is converted into the jelly gel and the change of the scattering occurs. The detection of specific proteins is mainly achieved by the change of scattered light or the change of transmitted light caused by the immune complex formed by the specific protein and the corresponding antibody or antigen, but the detection by scattered light is more sensitive and linear. Although the specific protein analyzer and the hemagglutination analyzer mainly use scattered light, the detection mode and the detection end point are different. For example, the coagulation function detection needs to accurately and accurately record the accurate contact time of the sample and the reagent, and The reagents are thoroughly mixed in the shortest time of contact with the sample to ensure accurate detection results. Therefore, the corresponding structures of the two instrument detection components are also different, and the wavelengths used in the various methods are also different, and the ratio of the sample to the reagent is also greatly different. Moreover, the current automated biochemical analyzers, blood coagulation analyzers, and specific protein analyzers are more difficult to combine multiple detection modes in one automated instrument due to high automation, large differences in detection methods, faster speed requirements, and more complex structures. Test. Utility model content

SUMMARY OF THE INVENTION It is an object of the present invention to provide a photodetecting device having a plurality of detection bits, each having a multi-angle, multi-wavelength source and at least one detector. It is suitable for multi-mode and multi-project inspection of fast automated optical analysis instruments, and the device is compact and easy to install. In this way, it is possible to perform functions such as biochemical detection, coagulation function detection and specific protein detection at any detection position on an automated instrument.

The technical solution for achieving the object of the present invention is:

A multi-detection position photodetecting device, the device comprising a detecting unit and a light source, wherein the detecting unit comprises a detector port, a transmitted light inlet, a scattered light inlet and a detection bit; the light source is connected through the transmitted light inlet and the scattered light inlet One or more detecting units, all of which are regularly and uniformly fixed into a unitary device by means of a fixed carrier, the detecting position is a bottom seal top opening, and a detector port and a transmitted light inlet are respectively arranged on the sides of each detecting position. And a diffused light inlet, wherein the transmitted light inlet is mounted in a relative position with the detector port, and the scattered light inlet is mounted on the other side.

A multi-detection photodetection device further comprising one or more monochromators, one end of which is connected to a light source, and the other end is connected to a transmitted light entrance and a scattered light entrance.

A multi-detection photoelectric detecting device, wherein the detecting position is a polygon detecting position of a bottom seal top opening, and one or more detector ports, one and one or more transmissions are respectively arranged on a peripheral side of the detecting position. a light inlet and one or more scattered light inlets, wherein the transmitted light inlet is mounted at a relative position with the detector port, the scattered light inlet is mounted on the other side, and the central axis of the scattered light inlet is 20° to 160° from the central axis of the detector port Angle.

One of the above preferred embodiments of the photoelectric detecting device: the detecting position is a square detecting position of the top opening of the bottom seal, and one detector port, one transmitted light inlet and two scattering are respectively arranged on the front, left, and right sides of the detecting position. The light inlet, wherein the transmitted light inlet and the detector port are mounted at opposite positions, and the scattered light inlet is mounted on the other two sides. Each detection bit is set to have a minimum angle of 5° to 85° formed by the line connecting any one of the sides to the center point of each detection bit.

Preferably, the photodetecting device has two detection schemes: the detection position is a square detection position of the top opening of the bottom seal, and one detector port, one transmitted light inlet and one scattering are respectively mounted on the front, left, and right sides of the detection position. The light inlet, wherein the transmitted light inlet and the detector port are mounted at opposite positions, and the scattered light inlet is mounted on either one of the other two sides. Each detection bit is set to have a minimum angle of 5° to 85° formed by the line connecting any one of the sides to the center point of each detection bit. A multi-detection position photoelectric detecting device, wherein the detecting position is a circular detecting position of a bottom seal top opening, Do not mount one or more detector ports, one or more transmitted light inlets, and one or more scattered light inlets on the surrounding side of the detection position, wherein the transmitted light inlet is mounted opposite to the detector port. Position, the scattered light inlet (3) is mounted on the other side, and the center axis of the scattered light inlet is at an angle of 20° to 160° to the central axis of the detector port.

One of the above preferred embodiments of the photodetecting device: the detecting position is a circular detecting position of the top opening of the bottom seal, and one detector port, one transmitted light inlet and four scattered light inlets are respectively arranged on the peripheral side of the detecting position. Wherein the transmitted light inlet and the detector port are mounted at opposite positions, the scattered light inlet is mounted on the other side, and the central axis of the scattered light inlet is at an angle of 45° to 145° with respect to the central axis of the detector port.

Preferably, the photodetecting device has two detection schemes: the detection position is a circular detection position of the bottom seal top opening, and two detector ports, two transmitted light entrances and two scattered light inlets are respectively arranged on the peripheral side of the detection position. Wherein the transmitted light inlet and the detector port are mounted at opposite positions, the scattered light inlet is mounted on the other side, and the central axis of the scattered light inlet is at an angle of 45° to 145° with respect to the central axis of the detector port.

A multi-detection photoelectric detecting device, the detecting unit further comprising a stirring device, the stirring device comprising a magnetic bar, a magnet and a motor, wherein the stirring device is installed at the bottom of the detecting position.

A multi-detection photodetection device, the detection unit further comprising a heating device mounted on an inner side of the side wall around the detection position, near the bottom position.

In the photodetection device of the above multiple detection bits, the center distance of each adjacent detection bit in the device is not more than 30 mm. Compared with the prior art, the utility model has the significant advantages that:

(1) The utility model has the advantages that the device has multiple detection positions, and the detection speed is fast, and each detection position has a scattering optical port and a transmission optical port at the same time, so that each detection bit can perform transmission light detection at the same time or separately. Scattered light detection, and therefore its detection performance is increased compared to currently common detection devices that are generally only scattered or only transmitted. Moreover, both the scattered light and the transmitted light of the device may be multi-wavelength, and the scattered light may be multi-angle. Therefore, the design device of the utility model not only can realize the rapid detection, but also has more detection modes and methods, and the sensitivity and the detection linear range are improved;

(2) The detection devices designed by the utility model can detect the same item at the same time, and can also detect different items at the same time, and the flexibility and efficiency thereof are greatly improved;

(3) The detection device designed by the utility model has an optimized design of the position of the detection position and the structure of the incident light entrance, so that the structure is not too large under the premise of satisfying a plurality of functions. When applied to automated instruments, the instrument is generally compact and intensive, facilitating instrument operation and saving space and materials.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a plan view of a square detection position of a photodetecting device of the present invention (1-detector port, 2-transmitted light entrance, 3- Scattered light entrance).

Fig. 2 is a square detection position of the photoelectric detecting device of the present invention, wherein a structure of the multi-wavelength converting device is arranged outside the transmitted light inlet. (4-monochromator, 5-light source).

3 is a top plan view of a circular detection position of the photodetecting device of the present invention.

4 is a top view of the circular detection position of the photoelectric detecting device of the present invention, and each detecting position is equipped with two detector ports. Fig. 5 is a schematic view of the bottom of the photoelectric detecting device of the present invention equipped with a stirring device and a heating device (7-detecting cup, 8-magnetic bar, 9-magnet, 10-motor, 11-heating device).

6 is a top view of the square detection position of the photodetecting device of the present invention, wherein each of the detection bits has a monochromator disposed on the transmitted light path to independently select different wavelengths for the respective detection bits.

detailed description

Embodiment 1 As shown in FIG. 1 and FIG. 2, a multi-detection photodetection device includes a detecting unit, a light source 5 and a monochromator 4, wherein the detecting unit includes a detector port 1 and a transmitted light port 2 , the scattered light inlet 3 and the detection bit 6; the light source 5 is connected to the monochromator 4, the monochromator 4 passes through the transmitted light inlet 2, and the four detecting units have two scattered light inlets 3, all of which are fixed in one In the device, the detection bit 6 is a square detection position of the bottom seal top opening, and one detector port 1, one transmitted light inlet 2 and two scattered light inlets 3 are respectively arranged on the front, rear, left and right sides of the detection position. Wherein the transmitted light entrance 2 and the detector port 1 are mounted at opposite positions, and the scattered light inlet 3 is mounted on the other two sides. Each detection bit is set to have a minimum angle of 5° to 85° formed by the line connecting any one of the sides to the center point of each detection bit.

As shown in FIG. 6, there may be four monochromators 4, and the light source 5 is connected to a monochromator that leads to each detection position by means of an optical fiber or other medium, and each monochromator communicates with the detection bit through the transmitted light entrance. Each of the monochromators can individually select transmitted light.

When using the detection position of the instrument for different wavelength biochemical and specific protein detection, the first detection position transmits light to select 340nm wavelength, the second detection position selects 405nm wavelength, and the third detection position selects 510nm wavelength for transmitted light detection, the fourth The detection site selects 670 nm scattered light for specific protein project detection. Each channel transmitted light monochromator is selected to provide the required transmitted light to each of the first, second and third channels, and the fourth channel monochromator is rotated to the closed position such that the detection bit has no transmitted light to enter, and in the detection position The 670 nm wavelength scattered light illuminates. In this way, each detection bit can perform different detections. Example 2 As shown in FIG. 3, a multi-detection position photodetecting device, the device comprises a detecting unit, a light source 5, a monochromator 4, a detector port 1, a transmitted light inlet 2, a scattered light inlet 3 and a detection bit 6; The light source 5 is connected to the monochromator 4, and the monochromator 4 is connected to the four detecting units through the transmitted light inlet 3. All the detecting units are fixed on one device, and the detecting bit 6 is a circular detecting position of the bottom sealed top opening. One detector port 1, one transmitted light inlet 2 and four scattered light inlets 3 are respectively arranged on the peripheral side of the detection position, wherein the transmitted light inlet 2 and the detector port 1 are mounted at opposite positions, and the scattered light entrance 3 Mounted on the other side, the center axis of the scattered light inlet is at an angle of 60° and 120° to the central axis of the detector port. When the instrument is used for coagulation and specific protein function detection, the first and second detection positions select 670 nm scattered light, and the third and fourth positions select 405 nm scattered light, at which time the respective wavelengths of the respective detection bits are turned on, and the transmitted light source is turned off. , each detection bit can perform scattered light detection according to the detected items.

When the device is used for transmission and scattering hybrid detection, the first and second detection bits select transmitted light, and the third and fourth bits selectively scatter light detection. At this time, the transmitted light source is turned on, and the wavelengths required for the first and second detection bits are provided by the rotation selection of the monochromator, and the scattered light sources required for the third and fourth positions are illuminated, and the transmitted light source is Scattered light detection is performed when the color picker is off. This also enables detection of multiple wavelengths and light sources with multiple detection bits. Example 3

As shown in FIG. 4, a multi-light source, multi-detection photoelectric detecting device, the device comprises a detecting unit, a light source 5 and a monochromator 4, wherein the detecting unit comprises a detector port 1, a transmitted light inlet 2, and a scattered light. The inlet 3 and the detection bit 6; the light source 5 is connected to the monochromator 4, the monochromator 4 is connected to the four detection units through the transmitted light inlet 3, all the detection units are fixed on one device, and the detection bit 6 is a bottom seal The circular detection positions of the top opening are respectively provided with two detector ports 1, two transmitted light inlets 2 and two scattered light inlets 3 on the peripheral side of the detection position, wherein the transmitted light inlet 2 and the detector port 1 are mounted on The relative position, the scattered light inlet 3 is mounted on the other side, and the central axis of the two detector ports is 120°. The central axis of the scattered light entrance is at an angle of 60° and 120° to the central axis of the detector port. When the instrument is used for simultaneous detection of dual-wavelength transmission and single-wavelength transmitted light, if the first and second detection bits are detected by dual wavelength, and the third and fourth detection bits are detected by single wavelength. Then, the two transmitted light in the first and second detection positions are lit, and the three or four detection bits only illuminate one transmitted light. In this way, each detection bit can be detected according to its own needs. Embodiment 4 As shown in FIG. 1, FIG. 2 and FIG. 6, a photoelectric detecting device with multiple detection positions, the device includes a detecting unit, a light source 5 and a monochromator 4, wherein the detecting unit includes a detector port 1, and a transmission unit Light entrance 2, scattered light entrance 3 and detection Bit 6. The light source 5 is connected to the monochromator 4, and the monochromator can be configured as a monochromatic device as shown in FIG. 6, but disposed in the optical path of each scattered light, so that the scattered light entrance connected to each monochromator can be selected. Wavelength optical signals. When different detection wavelengths of the device are required to be used for simultaneous detection of different wavelengths, the monochromator on the scattered light path of each detection bit can select different wavelengths of scattered light according to the detection requirements of each detection bit, so that each detection bit can be free. Perform different wavelengths of scattered light detection. Example 5

As shown in Fig. 5, a multi-detection photoelectric detecting device further comprises a stirring device equipped at the bottom of the detecting position, and the stirring system is composed of a magnetic rod 8, a magnet 9, and a motor 10 connected to the magnet. Before the detection or during the detection, the motor rotates to drive the magnet to rotate. When the magnet rotates, the magnetic rod in the detection cup can be driven by the magnetic force to stir the sample to be inspected in the detection cup. Example 6

As shown in FIG. 5, a multi-detection photodetection device further comprises a heating device at the bottom of the detection position, and the heating device is heated according to the instruction to ensure that the detection position maintains a proper and stable temperature.

Claims

Claim

A photodetecting device for multi-detection bits, characterized in that: the device comprises a detecting unit and a light source (5), wherein the detecting unit comprises a detector port (1), a transmitted light inlet (2), and a scattered light entrance ( 3) and detecting bit (6); the light source (5) is connected to one or more detecting units through the transmitted light inlet (2) and the scattered light inlet (3), and all detecting units are regularly fixed to one by a fixed carrier The whole device, the detection bit (6) is a bottom seal top opening, and a detector port (1), a transmitted light inlet [2) and a scattered light inlet (3) are respectively arranged on the side of each detection position, wherein the transmitted light is transmitted The inlet (2) is mounted in the opposite position to the detector port (1) and the diffused light inlet (3) is mounted on the other side.

2. Photodetection device according to claim 1, characterized in that the device further comprises one or more monochromators (4), one end of which is connected to the light source (5), the other end Connect the transmitted light inlet (2) and the scattered light inlet (3).

The photodetection device according to claim 1, wherein the detection bit (6) is a polygon detection bit of a bottom seal top opening, and one or more detections are respectively arranged on a peripheral side of the detection bit. Port (1), one and more transmitted light inlets (2) and one or more scattered light inlets (3), wherein the transmitted light inlet (2) and the detector port (1) are mounted at opposite positions The scattered light inlet (3) is mounted on the other side, and the center axis of the scattered light inlet is at an angle of 20° - 160° to the central axis of the detector port.

The photoelectric detecting device according to claim 3, wherein: the detecting bit (6) is a square detecting position of the top opening of the bottom seal, and one detector is mounted on the front, left, and right sides of the detecting position, respectively. a port (1), a transmitted light inlet (2) and two scattered light inlets (3), wherein the transmitted light inlet (2) is mounted at a relative position with the detector port (1), and the scattered light inlet (3) is mounted at On the other two sides, each detection bit is set to a minimum angle of 5° -85° formed by the line connecting any one of the sides to the center point of each detection bit.

The photodetection device according to claim 1, wherein the detection bit (6) is a circular detection position of the bottom seal top opening, and one or more are respectively mounted on the peripheral side of the detection position. Detector port (1), 1 and more transmitted light inlets (2) and 1 and more scattered light inlets (3), wherein the transmitted light inlet (2) and the detector port

(1) Installed in the opposite position, the diffused light inlet (3) is mounted on the other side, and the center axis of the scattered light inlet is at an angle of 20° - 160° to the axis of the detector port.

The photodetecting device according to claim 5, wherein: the detecting bit (6) is a circular detecting position of the bottom sealing top opening, and one detector port is respectively arranged on the peripheral side of the detecting position ( 1), 1 transmitted light inlet (2) and 4 scattered light inlets (3), wherein the transmitted light inlet (2) and the detector port (1) are mounted at opposite positions, the scattered light entrance

(3) Mounted on the other side, the center axis of the scattered light inlet is at an angle of 45° to 145° to the central axis of the detector port.

The photodetecting device according to claim 5, wherein: the detecting bit (6) is a circular detecting position of the bottom sealing top opening, and two detector ports are respectively arranged on the peripheral side of the detecting position ( 1), 2 transmitted light inlets (2) and 2 scattered light inlets (3), wherein the transmitted light inlet (2) and the detector port (1) are mounted at opposite positions, the scattered light entrance

The photodetecting device according to any one of claims 1 to 7, characterized in that the detecting unit further comprises a stirring device comprising a magnetic bar (8), a magnet (9) and a motor (10). The stirring device is mounted at the bottom of the detection position (6).

The photodetecting device according to any one of claims 1 to 8, characterized in that the detecting unit further comprises a heating device (12), the heating device (11) being mounted inside the side wall of the detecting position (6), Close to the bottom position.

The photodetecting device according to any one of claims 1 to 9, characterized in that: the center distance of each adjacent detection bit in the device is not more than 30 mm.