WO2014070993A1 - Nouveau système de détection des embolies dans le cerveau utilisant un dispositif photoacoustique doppler transcrânien capable de mesurer la vascularisation et la perfusion - Google Patents
Nouveau système de détection des embolies dans le cerveau utilisant un dispositif photoacoustique doppler transcrânien capable de mesurer la vascularisation et la perfusion Download PDFInfo
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- WO2014070993A1 WO2014070993A1 PCT/US2013/067713 US2013067713W WO2014070993A1 WO 2014070993 A1 WO2014070993 A1 WO 2014070993A1 US 2013067713 W US2013067713 W US 2013067713W WO 2014070993 A1 WO2014070993 A1 WO 2014070993A1
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- WIPO (PCT)
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- array
- brain
- transducer elements
- vasculature
- ultrasound
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
- A61B5/0042—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/06—Measuring blood flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Clinical applications
- A61B8/0808—Clinical applications for diagnosis of the brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/42—Details of probe positioning or probe attachment to the patient
- A61B8/4209—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames
- A61B8/4227—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames characterised by straps, belts, cuffs or braces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/488—Diagnostic techniques involving Doppler signals
Definitions
- An ischemic stroke is the result of neuronal death due to lack of oxygen, a deficit that produces focal brain injury. This event is accompanied by tissue changes consistent with an infarction (tissue death caused by an obstruction to blood supply) that can be identified with neuroimaging of the brain. Strokes are usually accompanied by symptoms, but they also may occur without producing clinical findings and be considered clinically silent. Additionally, many current transcranial imaging devices are severely limited by the aberrations caused by the skull or intervening tissues. A strong need to address these matters exists.
- mini-strokes At the time of stroke, mini-strokes, suspected strokes, or TIAs, magnetic resonance (MRI) and computed tomography (CT) of the brain (intracranial) and neck are the most employed techniques/devices used to look for blood vessel abnormalities, including stenosis, as a basis for stroke.
- MRI magnetic resonance
- CT computed tomography
- Such thicknesses is recorded and put into an array in computer memory, or a file on disc, or other media that then describes skull thicknesses. This helps establish an absolute reference frame for all work and in addition, alerts the operator as to where the thinnest parts of the skull are for easier insonification.
- the device consists of a rigid base shell or helmet 133 that is either placed around the patient's 112 head or the head is placed into the base shell 133 while the base shell 133 is affixed to the supporting surface upon which the patient 112 is laying.
- the main material for the base shell (base shell number) is a plastic, metal, or other like material that can be produced by thermoforming, injection molding, casting or other like means.
- the base shell 133 creates the framework for the helmet.
- silicone for example, as disclosed in U.S. Letters Patent 8,449,565, may be used, said patent being incorporated expressly herein by this reference, as if the contents of the same were set forth herein in their entirety.
- the helmet apparatus holds an array of seven custom Doppler transducers in lateral symmetry of the head, of which the two Carotid ultrasound transducers 208 and two temporal bone window ultrasound transducers 204 are bilateral, and of which the two eye ultrasound transducers 202, two temporal bone window ultrasound transducers 204, and basilar artery and vertebral artery ultrasound transducer 206 are remotely controlled in X-Y translation across the surface of the skull, pressured against the patient's 112 head in the Z direction at an appropriate pressure, pitch, and yaw angle rotation to aim the Doppler beam. These movements are carried out by a set of motor actuators 250, specified schematically in the drawing as TCD/Actuator Motor modules 250.
- the two carotid artery transducers 208 do not contain this translational control.
- the two eye transducers 202 and two carotid transducers 208 may be located on a more flexible substrate of the modules they are attached to, in order to prevent harmful levels of pressure applied to the eyes and the carotid arteries. In another exemplary embodiment, the two eye transducers 202 and two carotid transducers 208 may also be attached with adhesive.
- the wiring for the motor modules 250 and the transducers 300 is routed through the helmet to the base of the shell, where the connection interface to the power supply and data output modem 400 is located.
- the separate helmet members have electronic connections in the snap interface to route power and data through the helmet's wiring.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Acoustics & Sound (AREA)
- Hematology (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
La présente invention concerne un casque commandé et surveillé depuis un centre de données distant qui permet un classement et un triage rapide d'individus ayant des troubles cérébraux de type accident vasculaire cérébral, basé sur de nouvelles utilisations et l'enregistrement de différents processus de signal. L'imagerie photo-acoustique Doppler transcrânienne (DTC) et d'autres modalités générant rapidement des données médicales résultantes sont décrites, pour la prise en charge de patients présentant un trouble cérébral aigu de façon plus rapide.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2890157A CA2890157A1 (fr) | 2012-10-31 | 2013-10-31 | Nouveau systeme de detection des embolies dans le cerveau utilisant un dispositif photoacoustique doppler transcranien capable de mesurer la vascularisation et la perfusion |
| US14/070,264 US20140194740A1 (en) | 2013-01-07 | 2013-11-01 | Emboli detection in the brain using a transcranial doppler photoacoustic device capable of vasculature and perfusion measurement |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261720992P | 2012-10-31 | 2012-10-31 | |
| US61/720,992 | 2012-10-31 | ||
| US201361749618P | 2013-01-07 | 2013-01-07 | |
| US61/749,618 | 2013-01-07 | ||
| US201361833802P | 2013-06-11 | 2013-06-11 | |
| US61/833,802 | 2013-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2014070993A1 true WO2014070993A1 (fr) | 2014-05-08 |
Family
ID=50628041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2013/067713 WO2014070993A1 (fr) | 2012-10-31 | 2013-10-31 | Nouveau système de détection des embolies dans le cerveau utilisant un dispositif photoacoustique doppler transcrânien capable de mesurer la vascularisation et la perfusion |
Country Status (2)
| Country | Link |
|---|---|
| CA (1) | CA2890157A1 (fr) |
| WO (1) | WO2014070993A1 (fr) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140194740A1 (en) * | 2013-01-07 | 2014-07-10 | Cerebrosonics, Llc | Emboli detection in the brain using a transcranial doppler photoacoustic device capable of vasculature and perfusion measurement |
| EP3146902A1 (fr) * | 2015-09-28 | 2017-03-29 | Michael Zhadkevich | Dispositif de détection, monitorage et préventions simultanés d'embolie cérébrale |
| US9808260B2 (en) | 2014-05-04 | 2017-11-07 | Zhadkevich Medical, Inc. | Noninvasive protection from emboli |
| US20180214124A1 (en) * | 2016-01-05 | 2018-08-02 | Neural Analytics, Inc. | Systems and methods for detecting neurological conditions |
| US10130374B2 (en) | 2012-05-11 | 2018-11-20 | Michael Zhadkevich | Anti-embolic device and method |
| EP3415097A4 (fr) * | 2016-02-08 | 2019-01-23 | FUJIFILM Corporation | Dispositif de génération d'image d'onde acoustique et procédé de génération d'image d'onde acoustique |
| US10258348B2 (en) | 2015-01-27 | 2019-04-16 | Michael Zhadkevich | Devices and techniques for vascular compression |
| US10534894B2 (en) | 2016-04-15 | 2020-01-14 | BR Invention Holding, LLC | Mobile medicine communication platform and methods and uses thereof |
| US10617388B2 (en) | 2016-01-05 | 2020-04-14 | Neural Analytics, Inc. | Integrated probe structure |
| CN111110193A (zh) * | 2019-12-27 | 2020-05-08 | 华南师范大学 | 基于光声流速测量评估管径狭窄分数的装置及方法 |
| US11090026B2 (en) | 2016-01-05 | 2021-08-17 | Novasignal Corp. | Systems and methods for determining clinical indications |
| US11116515B2 (en) | 2012-05-11 | 2021-09-14 | Michael Zhadkevich | Anti-embolic device and method |
| US11207054B2 (en) | 2015-06-19 | 2021-12-28 | Novasignal Corp. | Transcranial doppler probe |
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| WO2009101618A1 (fr) * | 2008-02-12 | 2009-08-20 | Newval-Tech Knowledge Services And Investments Ltd | Casque téléphonique sans fil pour réduire l'exposition à un rayonnement nocif sur la base d'une distance estimée par rapport à un dispositif sans fil |
| US20120083717A1 (en) * | 2010-10-05 | 2012-04-05 | Cerevast Therapeutics | Non-Invasive Transcranial Ultrasound Apparatus |
| US20120165676A1 (en) * | 2010-12-22 | 2012-06-28 | Philip Chidi Njemanze | Neuravionic System for Life Support in High Performance Avionics |
-
2013
- 2013-10-31 WO PCT/US2013/067713 patent/WO2014070993A1/fr active Application Filing
- 2013-10-31 CA CA2890157A patent/CA2890157A1/fr not_active Abandoned
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