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WO2013166022A3 - Machine vision system for frozen aliquotter for biological samples - Google Patents

Machine vision system for frozen aliquotter for biological samples Download PDF

Info

Publication number
WO2013166022A3
WO2013166022A3 PCT/US2013/038880 US2013038880W WO2013166022A3 WO 2013166022 A3 WO2013166022 A3 WO 2013166022A3 US 2013038880 W US2013038880 W US 2013038880W WO 2013166022 A3 WO2013166022 A3 WO 2013166022A3
Authority
WO
WIPO (PCT)
Prior art keywords
frozen sample
frozen
machine vision
camera
vision system
Prior art date
Application number
PCT/US2013/038880
Other languages
French (fr)
Other versions
WO2013166022A2 (en
Inventor
Mohammadreza RAMEZANIFARD
Saeed Sokhanvar
Todd BASQUE
Peter L. FULLER
Matthew Sweetland
Original Assignee
Cryoxtract Instruments, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/489,234 external-priority patent/US20130286192A1/en
Priority claimed from US13/844,156 external-priority patent/US20140267713A1/en
Application filed by Cryoxtract Instruments, Llc filed Critical Cryoxtract Instruments, Llc
Priority to CN201380022571.9A priority Critical patent/CN104428678A/en
Priority to AU2013256489A priority patent/AU2013256489A1/en
Priority to BR112014026936A priority patent/BR112014026936A2/en
Priority to JP2015510387A priority patent/JP6108572B2/en
Priority to CA2870505A priority patent/CA2870505A1/en
Priority to EP13724056.0A priority patent/EP2845013A2/en
Publication of WO2013166022A2 publication Critical patent/WO2013166022A2/en
Publication of WO2013166022A3 publication Critical patent/WO2013166022A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N2035/00891—Displaying information to the operator
    • G01N2035/0091—GUI [graphical user interfaces]

Landscapes

  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Robotics (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Analysis (AREA)
  • Manipulator (AREA)

Abstract

A machine vision system for use with a system that takes frozen sample cores from samples that are in containers includes a camera. A processor is configured to receive image data from the camera and to determine locations where frozen sample cores have already been taken. A method of determining one or more locations where a frozen sample core have already been taken from frozen samples includes operating a robotic system to position one of the containers on a platform at a station for receiving the container while a frozen sample core is extracted from the frozen sample contained in the container. The camera is used to capture an image of the frozen sample. Contrast in the captured image is evaluated to identify one or more bore candidates. The processor uses the image to determine whether or not the bore candidates are real bores or artifacts.
PCT/US2013/038880 2012-04-30 2013-04-30 Machine vision system for frozen aliquotter for biological samples WO2013166022A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201380022571.9A CN104428678A (en) 2012-04-30 2013-04-30 Machine vision system for frozen aliquotter for biological samples
AU2013256489A AU2013256489A1 (en) 2012-04-30 2013-04-30 Machine vision system for frozen aliquotter for biological samples
BR112014026936A BR112014026936A2 (en) 2012-04-30 2013-04-30 machine vision system for use with a robotic system for taking a plurality of frozen sample cores from frozen samples that are contained in a respective container, and methods for calibrating a robotic system for taking a plurality of frozen cores. frozen sample from frozen samples that are contained in a respective container, taking a frozen sample core from a frozen sample that is contained in a container and determining one or more locations where frozen sample cores have already been taken from frozen samples
JP2015510387A JP6108572B2 (en) 2012-04-30 2013-04-30 Machine vision system for frozen aliquoters for biological samples
CA2870505A CA2870505A1 (en) 2012-04-30 2013-04-30 Machine vision system for frozen aliquotter for biological samples
EP13724056.0A EP2845013A2 (en) 2012-04-30 2013-04-30 Machine vision system for frozen aliquotter for biological samples

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261640662P 2012-04-30 2012-04-30
US61/640,662 2012-04-30
US13/489,234 2012-06-05
US13/489,234 US20130286192A1 (en) 2012-04-30 2012-06-05 Machine Vision System for Frozen Aliquotter for Biological Samples
US13/844,156 US20140267713A1 (en) 2013-03-15 2013-03-15 Machine Vision System for Frozen Aliquotter for Biological Samples
US13/844,156 2013-03-15

Publications (2)

Publication Number Publication Date
WO2013166022A2 WO2013166022A2 (en) 2013-11-07
WO2013166022A3 true WO2013166022A3 (en) 2014-03-13

Family

ID=49515022

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/038880 WO2013166022A2 (en) 2012-04-30 2013-04-30 Machine vision system for frozen aliquotter for biological samples

Country Status (7)

Country Link
EP (1) EP2845013A2 (en)
JP (1) JP6108572B2 (en)
CN (1) CN104428678A (en)
AU (1) AU2013256489A1 (en)
BR (1) BR112014026936A2 (en)
CA (1) CA2870505A1 (en)
WO (1) WO2013166022A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115223034A (en) * 2021-04-16 2022-10-21 中国科学院上海药物研究所 Method and device for automatic hole selection of cryo-electron microscope

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060015262A1 (en) * 2003-09-08 2006-01-19 Bioimagene, Inc., San Mateo, Ca Method and system for automated quantitation of tissue micro-array (TMA) digital image analysis
US20060199169A1 (en) * 2005-03-02 2006-09-07 Exb Technology, Inc. Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation
US20090019877A1 (en) * 2006-01-13 2009-01-22 Dale Larson Systems, Methods and Devices for Frozen Sample Distribution
US20100303337A1 (en) * 2009-05-29 2010-12-02 Aaron Wallack Methods and Apparatus for Practical 3D Vision System
US20110194749A1 (en) * 2010-02-09 2011-08-11 International Genomics Consortium System and method for laser dissection

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040085443A1 (en) * 2000-12-13 2004-05-06 Kallioniemi Olli P Method and system for processing regions of interest for objects comprising biological material
WO2006009733A2 (en) * 2004-06-18 2006-01-26 Covance, Inc. Frozen tissue microarray

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060015262A1 (en) * 2003-09-08 2006-01-19 Bioimagene, Inc., San Mateo, Ca Method and system for automated quantitation of tissue micro-array (TMA) digital image analysis
US20060199169A1 (en) * 2005-03-02 2006-09-07 Exb Technology, Inc. Tissue punch and tissue sample labeling methods and devices for microarray preparation, archiving and documentation
US20090019877A1 (en) * 2006-01-13 2009-01-22 Dale Larson Systems, Methods and Devices for Frozen Sample Distribution
US20100303337A1 (en) * 2009-05-29 2010-12-02 Aaron Wallack Methods and Apparatus for Practical 3D Vision System
US20110194749A1 (en) * 2010-02-09 2011-08-11 International Genomics Consortium System and method for laser dissection

Also Published As

Publication number Publication date
WO2013166022A2 (en) 2013-11-07
CN104428678A (en) 2015-03-18
EP2845013A2 (en) 2015-03-11
JP6108572B2 (en) 2017-04-05
JP2015516077A (en) 2015-06-04
AU2013256489A1 (en) 2014-10-30
BR112014026936A2 (en) 2017-06-27
CA2870505A1 (en) 2013-11-07

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