WO2013036210A1 - Medical face mask coated with mangosteen shell extracts - Google Patents
Medical face mask coated with mangosteen shell extracts Download PDFInfo
- Publication number
- WO2013036210A1 WO2013036210A1 PCT/TH2012/000041 TH2012000041W WO2013036210A1 WO 2013036210 A1 WO2013036210 A1 WO 2013036210A1 TH 2012000041 W TH2012000041 W TH 2012000041W WO 2013036210 A1 WO2013036210 A1 WO 2013036210A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mangosteen shell
- coated
- shell extracts
- medical
- face mask
- Prior art date
Links
- 235000017048 Garcinia mangostana Nutrition 0.000 title claims abstract description 17
- 240000006053 Garcinia mangostana Species 0.000 title claims abstract description 17
- 239000000284 extract Substances 0.000 title claims abstract description 17
- 239000000835 fiber Substances 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 244000052616 bacterial pathogen Species 0.000 abstract description 12
- 201000008827 tuberculosis Diseases 0.000 abstract description 9
- 201000010099 disease Diseases 0.000 abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 8
- 210000002345 respiratory system Anatomy 0.000 abstract description 8
- 239000002245 particle Substances 0.000 abstract description 7
- 238000003892 spreading Methods 0.000 abstract description 6
- 239000000428 dust Substances 0.000 abstract description 3
- 239000000969 carrier Substances 0.000 abstract description 2
- 241000894006 Bacteria Species 0.000 description 8
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 8
- 208000018569 Respiratory Tract disease Diseases 0.000 description 4
- YRKKJHJIWCRNCW-UHFFFAOYSA-N beta-Mangostin Chemical compound O1C2=CC(O)=C(OC)C(CC=C(C)C)=C2C(=O)C2=C1C=C(OC)C(CC=C(C)C)=C2O YRKKJHJIWCRNCW-UHFFFAOYSA-N 0.000 description 4
- VEZXFTKZUMARDU-UHFFFAOYSA-N gamma-mangostin Chemical compound OC1=C(O)C(CC=C(C)C)=C2C(=O)C3=C(O)C(CC=C(C)C)=C(O)C=C3OC2=C1 VEZXFTKZUMARDU-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000011787 zinc oxide Substances 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- GNRIZKKCNOBBMO-UHFFFAOYSA-N alpha-mangostin Chemical compound OC1=C(CC=C(C)C)C(O)=C2C(=O)C3=C(CC=C(C)C)C(OC)=C(O)C=C3OC2=C1 GNRIZKKCNOBBMO-UHFFFAOYSA-N 0.000 description 3
- 230000002365 anti-tubercular Effects 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 241000712461 unidentified influenza virus Species 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 2
- HVXHJNVYRXRHNX-UHFFFAOYSA-N Garcinone B Chemical compound O1C(C)(C)C=CC2=C(C(=O)C=3C(=CC(O)=C(C=3O)CC=C(C)C)O3)C3=CC(O)=C21 HVXHJNVYRXRHNX-UHFFFAOYSA-N 0.000 description 2
- 208000002979 Influenza in Birds Diseases 0.000 description 2
- QTDMGAWIBXJNRR-UHFFFAOYSA-N Mangostin Natural products CC(=CCc1c(O)cc2Oc3cc(C)c(O)c(CC=C(C)C)c3C(=O)c2c1O)C QTDMGAWIBXJNRR-UHFFFAOYSA-N 0.000 description 2
- 241000186359 Mycobacterium Species 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- ZVFQDLCERPGZMO-UHFFFAOYSA-N alpha-mangostin Natural products OC1=C(CC=C(C)C)C(O)=C2C(=O)C3=C(CC=C(C)C)C(OC)=C(O)C=C3CC2=C1 ZVFQDLCERPGZMO-UHFFFAOYSA-N 0.000 description 2
- 206010064097 avian influenza Diseases 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- ACRGTLGOYYTGNX-UHFFFAOYSA-N gamma-mangostin Natural products OC1=C(O)C=C2C(=O)C3=C(O)C(CC=C(C)C)=C(O)C=C3OC2=C1 ACRGTLGOYYTGNX-UHFFFAOYSA-N 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 238000009958 sewing Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- JNELGWHKGNBSMD-UHFFFAOYSA-N xanthone Chemical group C1=CC=C2C(=O)C3=CC=CC=C3OC2=C1 JNELGWHKGNBSMD-UHFFFAOYSA-N 0.000 description 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003097 anti-respiratory effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D13/00—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
- A41D13/05—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
- A41D13/11—Protective face masks, e.g. for surgical use, or for use in foul atmospheres
- A41D13/1192—Protective face masks, e.g. for surgical use, or for use in foul atmospheres with antimicrobial agent
Definitions
- This invention is related to medical mask, especially the medical mask coated with mangosteen shell extracts.
- Medical face mask coated with mangosteen shell extracts according to this invention, is capable of filtering-out air dust particles and killing bacteria.
- the middle layer of the mask is coated with mangosteen shell extracts that has anti-tuberculosis and anti-respiratory tract infection properties. After use, the mask can continually destroy germs that are trapped on it, thus, lowering the survival rate of carriers for infectious diseases.
- Respiratory tract diseases are caused by the infections of the respiratory tract, from nose, to air passage, and to the lungs.
- Disease-causing factors are often microbes, including viruses and bacteria.
- Virus-induced diseases may include common cold, influenza, avian influenza, and the new strain of influenza virus of 2009 or H1N1.
- Bacteria-induced diseases may include pneumonia and tuberculosis.
- the highly contagious diseases with great chance of spreading are influenza, avian influenza, and the new strain of influenza virus of 2009 or H1N1. If there were a spreading, there would be much loss to the country's economy and society.
- Tuberculosis is one of the diseases induced by Mycobacterium Tuberbulosis that can infected any organs in the body, but most importantly in the lungs, through inhalation of small phlegm particles with bacteria floating in the air into the lungs.
- Respiratory tract diseases and tuberculosis can spread and infect the patients in many ways, including:
- Germs that came from cough and sneeze in small particle forms can contaminate the air for a day or many days depending on the type of germ and surrounding environment.
- wearing a medical mask can filter-out and reduce the amount of phlegm particles that come out during one's cough or sneeze, which can sequentially reduce the spreading of germs from respiratory tract disease patients to others and the environment of up to 90%.
- the medical mask comprising of three layers whereby the first layer is the dust filter layer, the second layer is for germ filtration, and the third layer is coated with nano zinc oxide solution at 500-2000 ppm wherein the zinc oxide solution is derived from the mixtures of nano zinc oxide (size 20-40 nanometer) at 0.05-0.2 grams, cohesive (acrylic polymer 40%w/v) at 30 milliliters, and solvent (distilled water) at 970 milliliters.
- this invention has, thus, developed a medical mask that has the capacity to kill tuberculosis and other germs affecting the respiratory system by coating the medical mask with mangosteen shell extracts.
- the medical mask according to this invention is also affordable and is safe for human since it is a natural extract.
- mangosteen shell extracts Large chemical group that is derived from mangosteen shell extracts is the Xanthone group that comprises of alpha-mangostin (a-mangostin), beta-mangosteen ( ⁇ -mangostin), and gamma- mangostin ( ⁇ -mangostin) in largest quantities.
- the extracted chemicals from mangosteen had been studied to have therapeutic effects in many studies, but most importantly, their antituberculosis (Mycobacterium tuberbulosis) properties.
- Mycobacterium tuberbulosis antituberculosis
- Figure 1 is the medical face mask coated with mangosteen shell extracts that comprises of 3 layers: outer layer (1), middle layer (2), and inner layer (3).
- the outer layer (1) and inner layer (3) are made of polypropylene spunbond fiber.
- the middle layer (2) is made of melt blown filter that has been coated with mangosteen shell extract in ethanol solution or in other appropriate solution at the concentration of 1 to 50 per unit weight.
- the process of coating of mangosteen shell extracts on the middle layer (2) starts from feeding the middle layer (2) into the high-pressure spraying machine or by dipping process. Sequentially, the middle layer (2) will be heated, thereby, causing all of the solution to evaporate from the middle layer (2). In the final process, the middle layer will be rolled up for storage and will later be incorporated in the mask production process.
- the middle layer (2) after the mentioned coating process has the special capacity to kill bacteria and tuberculosis as shown by the testing result in Figure 2.
- the 3 mask layers will be placed on top of each other in sequence, following by sewing all 3 layers together using the automatic sewing machine or by hand to obtain the medical face mask coated with mangosteen shell extracts.
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
Abstract
This invention is related to the medical face mask coated with mangosteen shell extracts with special and distinguishable feature in that, apart of its capacity to filter-out dust particles, the middle layer which is coated with mangosteen shell extracts has the capacity to protect against tuberculosis and other germs affecting the respiratory system. Furthermore, after use, the medical mask specified in this invention can still kill any germs that are attached on it; thereby, reducing the risk of spreading of diseases through carriers.
Description
MEDICAL FACE MASK COATED WITH MANGOSTEEN SHELL EXTRACTS
TECHNICAL FIELD
This invention is related to medical mask, especially the medical mask coated with mangosteen shell extracts. Medical face mask coated with mangosteen shell extracts, according to this invention, is capable of filtering-out air dust particles and killing bacteria. The middle layer of the mask is coated with mangosteen shell extracts that has anti-tuberculosis and anti-respiratory tract infection properties. After use, the mask can continually destroy germs that are trapped on it, thus, lowering the survival rate of carriers for infectious diseases. BACKGROUND OF THE INVENTION
As today's world is moving towards globalization— with advancements in technologies, communications and transportation systems, economic development, free-trade, and growing tourism industry— it is becoming more critical that, if there were any spread of disease from human to human, there would also be a chance of spreading, in fact rapidly and in wide perimeter, from one region to another region or to another country. Herein, there are many types of infectious diseases that have severe impacts on public health and welfare of citizens, and one type is the respiratory tract diseases. From the most recent situation surrounding the new strain of influenza virus of 2009 or H1N1 that had spread throughout the world, causing newly infected cases and deaths to increase continually, with the prediction that this strain would become more fatal in the near future; therefore, it is important to become more conscious of the methods to protect oneself against the spreading of such diseases.
Respiratory tract diseases are caused by the infections of the respiratory tract, from nose, to air passage, and to the lungs. Disease-causing factors are often microbes, including viruses and bacteria.
Virus-induced diseases may include common cold, influenza, avian influenza, and the new strain of influenza virus of 2009 or H1N1. Bacteria-induced diseases may include pneumonia and tuberculosis. Herein, the highly contagious diseases with great chance of spreading are influenza, avian influenza, and the new strain of influenza virus of 2009 or H1N1. If there were a spreading, there would be much loss to the country's economy and society.
Tuberculosis is one of the diseases induced by Mycobacterium Tuberbulosis that can infected any organs in the body, but most importantly in the lungs, through inhalation of small phlegm particles with bacteria floating in the air into the lungs.
Respiratory tract diseases and tuberculosis can spread and infect the patients in many ways, including:
(1) Sneezes, coughs, or through breathing on each other. The germs will contaminate the small phlegm particles, nasal mucus, or saliva, and will infect anyone close by who inhale the particles.
(2) Through contact with patient's nasal mucus, saliva, or by being located nearby the patient.
(3) Through contact with patient's items or belongings, such as clothes, napkin, towel, glass, spoon, plate, bowl, toy, book, or other items that are contaminated with germs.
Germs that came from cough and sneeze in small particle forms can contaminate the air for a day or many days depending on the type of germ and surrounding environment. Herein, it has been examined that wearing a medical mask can filter-out and reduce the amount of phlegm particles that come out during one's cough or sneeze, which can sequentially reduce the spreading of germs from respiratory tract disease patients to others and the environment of up to 90%.
Presently, it is known that medical masks can protect oneself by disallowing bacteria from entering the respiratory system, but many of them do not have the capability to kill germs. Below are registered patents that are related to this invention.
Thai petty patent number 1928 granted on September 2, 2005 under the name "medical mask" has stated the medical mask that is made from a water resistant polypropylene spunbond fiber that forms at least 2 layers and has middle layer that is made from melt blown filter fiber with stretchable rubber attached to the side of the medical mask. Herein, the medical mask according to this petty patent can only protect against bacterial entrance into the respiratory system, but does not have the capacity to kill tuberculosis bacteria and other germs affecting the respiratory system.
Thai petty patent number 5016 granted on July 20, 2009 under the name "medical mask" has declared the medical mask comprising of three layers whereby the first layer is the dust filter layer, the second layer is for germ filtration, and the third layer is coated with nano zinc oxide solution at 500-2000 ppm wherein the zinc oxide solution is derived from the mixtures of nano zinc oxide (size 20-40 nanometer) at 0.05-0.2 grams, cohesive (acrylic polymer 40%w/v) at 30 milliliters, and solvent (distilled water) at 970 milliliters. Herein, even if the medical mask described in this petty patent has the capacity to kill tuberculosis and other germs affecting the respiratory tract, but the nano zinc oxide has a high cost and, if used in high quantity, can be harmful to the cells. Considering the problems as stated above, this invention has, thus, developed a medical mask that has the capacity to kill tuberculosis and other germs affecting the respiratory system by coating the medical mask with mangosteen shell extracts. Wherein, other than the capacity to effectively kill tuberculosis and other germs affecting the respiratory tract, the medical mask according to this invention is also affordable and is safe for human since it is a natural extract. Large chemical group that is derived from mangosteen shell extracts is the Xanthone group that comprises of alpha-mangostin (a-mangostin), beta-mangosteen (β-mangostin), and gamma- mangostin (γ-mangostin) in largest quantities. The extracted chemicals from mangosteen had been studied to have therapeutic effects in many studies, but most importantly, their antituberculosis (Mycobacterium tuberbulosis) properties. Herein, the research conducted by Associate Professor Dr. Sunit Suksamrarn, who is one of the inventors of this invention had discovered that alpha-mangostin, which is found in largest quantity in the Xanthone group, has the capacity to inhibit Mycobacterium tuberculosis with minimum inhibitory concentration (MIC) of 6.25 microgram/millilitre. Furthermore, beta-mangostin and garcinone B had been shown to produce to same results. BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 Medical mask according to this invention
Figure 2 Anti-tuberculosis effect of middle layer using disk diffusion method
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
Figure 1 is the medical face mask coated with mangosteen shell extracts that comprises of 3 layers: outer layer (1), middle layer (2), and inner layer (3). The outer layer (1) and inner layer (3) are made of polypropylene spunbond fiber. The middle layer (2) is made of melt blown filter that has been coated with mangosteen shell extract in ethanol solution or in other appropriate solution at the concentration of 1 to 50 per unit weight.
The process of coating of mangosteen shell extracts on the middle layer (2) starts from feeding the middle layer (2) into the high-pressure spraying machine or by dipping process. Sequentially, the middle layer (2) will be heated, thereby, causing all of the solution to evaporate from the middle layer (2). In the final process, the middle layer will be rolled up for storage and will later be incorporated in the mask production process. The middle layer (2) after the mentioned coating process has the special capacity to kill bacteria and tuberculosis as shown by the testing result in Figure 2. As shown in Figure 2, the filters which had been coated with mangosteen extracts at low concentration (5) and high concentration (6), when compared with common filter (4), it can be seen that filters (5) and (6) exhibited large clear zones, which indicated that bacteria could not grow in and around the filters, whereas the common filter (4) exhibited no such anti-bacterial property as no clear zone was present around it.
In the mask production process, the 3 mask layers will be placed on top of each other in sequence, following by sewing all 3 layers together using the automatic sewing machine or by hand to obtain the medical face mask coated with mangosteen shell extracts.
Claims
1. Medical face mask coated with mangosteen shell extracts comprising three filter layers: outer layer (1), middle layer (2), and inner layer (3) wherein the outer layer (1) and inner layer (3) are made of popypropylene spunbond fiber and the middle layer (2) is made of melt blown fiber, with the special feature being the middle layer (2) is coated with mangosteen shell extracts in ethanol solution at the concentrations of 1 to 50 per unit weight.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TH1103000929U TH8576C3 (en) | 2011-09-06 | A mask coated with an extract of mangosteen. | |
TH1103000929 | 2011-09-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2013036210A1 true WO2013036210A1 (en) | 2013-03-14 |
Family
ID=47832456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/TH2012/000041 WO2013036210A1 (en) | 2011-09-06 | 2012-09-04 | Medical face mask coated with mangosteen shell extracts |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2013036210A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104287222A (en) * | 2014-10-28 | 2015-01-21 | 无锡快邦医疗科技有限公司 | Medical mask |
CN105167250A (en) * | 2015-08-17 | 2015-12-23 | 广州阳普医疗科技股份有限公司 | Mask and preparation method thereof |
RU2632636C2 (en) * | 2016-03-30 | 2017-10-06 | Алла Ивановна Вдовенко | Medical antimicrobial mask, method for its manufacture and applications |
CN107936355A (en) * | 2017-11-27 | 2018-04-20 | 桂林市和鑫防水装饰材料有限公司 | Polyethylene polypropylene polymer membranes |
US11453849B1 (en) | 2021-11-03 | 2022-09-27 | Wing Hei Dennis Poon | Micro algae culturing device |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040208902A1 (en) * | 2003-04-18 | 2004-10-21 | Gupta Shyam K. | Controlled-release nano-diffusion delivery systems for cosmetic and pharmaceutical compositions |
CN101028070A (en) * | 2007-04-13 | 2007-09-05 | 桂林莱茵生物科技股份有限公司 | Mangosteen extract, its production and use |
WO2010023370A1 (en) * | 2008-08-26 | 2010-03-04 | Deltalyo Valmy | Multilayer composition for a breathing mask |
-
2012
- 2012-09-04 WO PCT/TH2012/000041 patent/WO2013036210A1/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040208902A1 (en) * | 2003-04-18 | 2004-10-21 | Gupta Shyam K. | Controlled-release nano-diffusion delivery systems for cosmetic and pharmaceutical compositions |
CN101028070A (en) * | 2007-04-13 | 2007-09-05 | 桂林莱茵生物科技股份有限公司 | Mangosteen extract, its production and use |
WO2010023370A1 (en) * | 2008-08-26 | 2010-03-04 | Deltalyo Valmy | Multilayer composition for a breathing mask |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104287222A (en) * | 2014-10-28 | 2015-01-21 | 无锡快邦医疗科技有限公司 | Medical mask |
CN105167250A (en) * | 2015-08-17 | 2015-12-23 | 广州阳普医疗科技股份有限公司 | Mask and preparation method thereof |
RU2632636C2 (en) * | 2016-03-30 | 2017-10-06 | Алла Ивановна Вдовенко | Medical antimicrobial mask, method for its manufacture and applications |
CN107936355A (en) * | 2017-11-27 | 2018-04-20 | 桂林市和鑫防水装饰材料有限公司 | Polyethylene polypropylene polymer membranes |
US11453849B1 (en) | 2021-11-03 | 2022-09-27 | Wing Hei Dennis Poon | Micro algae culturing device |
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