WO2013016598A3 - Procédés pour réduire une lésion de reperfusion en utilisant un porteur de monoxyde de carbone à base d'hémoglobine - Google Patents
Procédés pour réduire une lésion de reperfusion en utilisant un porteur de monoxyde de carbone à base d'hémoglobine Download PDFInfo
- Publication number
- WO2013016598A3 WO2013016598A3 PCT/US2012/048450 US2012048450W WO2013016598A3 WO 2013016598 A3 WO2013016598 A3 WO 2013016598A3 US 2012048450 W US2012048450 W US 2012048450W WO 2013016598 A3 WO2013016598 A3 WO 2013016598A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carbon monoxide
- hemoglobin
- methods
- based carbon
- reperfusion injury
- Prior art date
Links
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 title abstract 3
- 229910002091 carbon monoxide Inorganic materials 0.000 title abstract 3
- 102000001554 Hemoglobins Human genes 0.000 title abstract 2
- 108010054147 Hemoglobins Proteins 0.000 title abstract 2
- 206010063837 Reperfusion injury Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000010410 reperfusion Effects 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne généralement des procédés pour réduire une lésion de reperfusion. Spécifiquement, la présente invention concerne l'administration d'un porteur de monoxyde de carbone à base d'hémoglobine à un sujet, avant ou après chirurgie, pour réduire une lésion résultant d'une reperfusion par administration de monoxyde de carbone et d'oxygène à un tissu ischémique.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161512335P | 2011-07-27 | 2011-07-27 | |
US61/512,335 | 2011-07-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013016598A2 WO2013016598A2 (fr) | 2013-01-31 |
WO2013016598A3 true WO2013016598A3 (fr) | 2013-03-21 |
Family
ID=47601767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/048450 WO2013016598A2 (fr) | 2011-07-27 | 2012-07-27 | Procédés pour réduire une lésion de reperfusion en utilisant un porteur de monoxyde de carbone à base d'hémoglobine |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2013016598A2 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018138360A1 (fr) | 2017-01-28 | 2018-08-02 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) | Substituts sanguins transportant de l'oxygène et leur utilisation en tant que véhicules d'administration |
CA3070172A1 (fr) | 2017-07-18 | 2019-01-24 | VirTech Bio, Inc. | Substituts sanguins comprenant de l'hemoglobine et procedes de fabrication |
CN114377155B (zh) * | 2022-01-14 | 2023-11-10 | 吴诗熳 | 一种造影剂、造影剂的制备方法及其应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3888249A (en) * | 1973-11-02 | 1975-06-10 | David L Spencer | Arterial infusion catheter |
US20060234915A1 (en) * | 2005-03-07 | 2006-10-19 | Sangart, Inc. | Compositions and methods for delivering carbon monoxide (CO) and nitric oxide (NO) to tissue using heme proteins as carriers |
US7625862B2 (en) * | 2002-01-11 | 2009-12-01 | Sangart, Inc. | Method for making a high oxygen affinity modified hemoglobin for oxygen transport |
US20120196270A1 (en) * | 2011-02-02 | 2012-08-02 | Sangart, Inc. | Methods for preserving an organ for transplantation using a hemoglobin-carbon monoxide complex |
-
2012
- 2012-07-27 WO PCT/US2012/048450 patent/WO2013016598A2/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3888249A (en) * | 1973-11-02 | 1975-06-10 | David L Spencer | Arterial infusion catheter |
US7625862B2 (en) * | 2002-01-11 | 2009-12-01 | Sangart, Inc. | Method for making a high oxygen affinity modified hemoglobin for oxygen transport |
US20060234915A1 (en) * | 2005-03-07 | 2006-10-19 | Sangart, Inc. | Compositions and methods for delivering carbon monoxide (CO) and nitric oxide (NO) to tissue using heme proteins as carriers |
US20090082257A1 (en) * | 2005-03-07 | 2009-03-26 | Sangart, Inc. | MalPEG-Hb conjugate- containing compositions for delivering carbon monoxide (CO) to cells |
US20120196270A1 (en) * | 2011-02-02 | 2012-08-02 | Sangart, Inc. | Methods for preserving an organ for transplantation using a hemoglobin-carbon monoxide complex |
Non-Patent Citations (2)
Title |
---|
BURMEISTER M ET AL.: "Effect of prophylactic or therapeutic application of bovine haemoglobin HBOC-200 on ischaemia-reperfusion injury following acute coronary ligature in rats.", BR J ANAESTH, vol. 95, 2005, pages 737 - 745 * |
CRETEUR ET AL.: "Potential Uses of Hemoglobin-based Oxygen Carriers in Critical Care Medicine", vol. 25, 2009, pages 311 - 324 * |
Also Published As
Publication number | Publication date |
---|---|
WO2013016598A2 (fr) | 2013-01-31 |
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