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WO2013004361A3 - Composite zirconia-calcium phosphate ceramic for dental implants - Google Patents

Composite zirconia-calcium phosphate ceramic for dental implants Download PDF

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Publication number
WO2013004361A3
WO2013004361A3 PCT/EP2012/002721 EP2012002721W WO2013004361A3 WO 2013004361 A3 WO2013004361 A3 WO 2013004361A3 EP 2012002721 W EP2012002721 W EP 2012002721W WO 2013004361 A3 WO2013004361 A3 WO 2013004361A3
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WO
WIPO (PCT)
Prior art keywords
calcium phosphate
grains
zirconia
dental implants
nanocomposite
Prior art date
Application number
PCT/EP2012/002721
Other languages
French (fr)
Other versions
WO2013004361A2 (en
Inventor
Daniel Grüner
Jenny FÄLDT
Erik Adolfsson
Zhijan Shen
Original Assignee
Nobel Biocare Services Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobel Biocare Services Ag filed Critical Nobel Biocare Services Ag
Publication of WO2013004361A2 publication Critical patent/WO2013004361A2/en
Publication of WO2013004361A3 publication Critical patent/WO2013004361A3/en

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    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/447—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on phosphates, e.g. hydroxyapatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/10—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on aluminium oxide
    • C04B35/111—Fine ceramics
    • C04B35/117—Composites
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
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    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/48—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on zirconium or hafnium oxides, zirconates, zircon or hafnates
    • C04B35/486—Fine ceramics
    • C04B35/488—Composites
    • C—CHEMISTRY; METALLURGY
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    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/64—Burning or sintering processes
    • C04B35/645—Pressure sintering
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    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3205—Alkaline earth oxides or oxide forming salts thereof, e.g. beryllium oxide
    • C04B2235/3208—Calcium oxide or oxide-forming salts thereof, e.g. lime
    • C04B2235/3212—Calcium phosphates, e.g. hydroxyapatite
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    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3217—Aluminum oxide or oxide forming salts thereof, e.g. bauxite, alpha-alumina
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    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3224—Rare earth oxide or oxide forming salts thereof, e.g. scandium oxide
    • C04B2235/3225—Yttrium oxide or oxide-forming salts thereof
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    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3231—Refractory metal oxides, their mixed metal oxides, or oxide-forming salts thereof
    • C04B2235/3244—Zirconium oxides, zirconates, hafnium oxides, hafnates, or oxide-forming salts thereof
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    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3231—Refractory metal oxides, their mixed metal oxides, or oxide-forming salts thereof
    • C04B2235/3244—Zirconium oxides, zirconates, hafnium oxides, hafnates, or oxide-forming salts thereof
    • C04B2235/3246—Stabilised zirconias, e.g. YSZ or cerium stabilised zirconia
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    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/50—Constituents or additives of the starting mixture chosen for their shape or used because of their shape or their physical appearance
    • C04B2235/54—Particle size related information
    • C04B2235/5418—Particle size related information expressed by the size of the particles or aggregates thereof
    • C04B2235/5445—Particle size related information expressed by the size of the particles or aggregates thereof submicron sized, i.e. from 0,1 to 1 micron
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    • C04B2235/65—Aspects relating to heat treatments of ceramic bodies such as green ceramics or pre-sintered ceramics, e.g. burning, sintering or melting processes
    • C04B2235/656—Aspects relating to heat treatments of ceramic bodies such as green ceramics or pre-sintered ceramics, e.g. burning, sintering or melting processes characterised by specific heating conditions during heat treatment
    • C04B2235/6562—Heating rate
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    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/65—Aspects relating to heat treatments of ceramic bodies such as green ceramics or pre-sintered ceramics, e.g. burning, sintering or melting processes
    • C04B2235/66—Specific sintering techniques, e.g. centrifugal sintering
    • C04B2235/666—Applying a current during sintering, e.g. plasma sintering [SPS], electrical resistance heating or pulse electric current sintering [PECS]
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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Composite Materials (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)

Abstract

A bioactive ceramic nanocomposite is described as follows. The composite material comprises a ceramic nanocomposite including a plurality of first grains which include calcium phosphate. The average grain size is one micron or less. The calcium phosphate is present in the nanocomposite material in the range of 10% by weight to 70% by weight based on the total weight of the nanocomposite material. A plurality of second grains is rapid sintered to the calcium phosphate-containing grains by using a dynamic sintering technique, such as spark plasma sintering (SPS). The second type of grains may be selected from the group consisting of zirconia and alumina and also have an average grain size of one micron or less. Preferably the zirconia contains 2-10 wt% yttria.
PCT/EP2012/002721 2011-07-06 2012-06-28 Composite ceramic for dental implants WO2013004361A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1111549.0A GB201111549D0 (en) 2011-07-06 2011-07-06 Composite ceramic for dental implants
GBGB1111549.0 2011-07-06

Publications (2)

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WO2013004361A2 WO2013004361A2 (en) 2013-01-10
WO2013004361A3 true WO2013004361A3 (en) 2013-08-29

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PCT/EP2012/002721 WO2013004361A2 (en) 2011-07-06 2012-06-28 Composite ceramic for dental implants

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WO (1) WO2013004361A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2640853C2 (en) * 2012-08-20 2018-01-12 Керамтек Гмбх Composite material based on zirconium oxide
EP2956427B1 (en) 2013-02-13 2019-04-10 CeramTec GmbH Zirconium oxide-based multi-phase materials
WO2015168332A2 (en) 2014-04-30 2015-11-05 Osseodyne Surgical Solutions, Llc Osseointegrative surgical implant
CN104496459B (en) * 2014-12-02 2016-12-07 佛山铭乾科技有限公司 A kind of Nano-grained Hydroxyapatite Ceramics and preparation method thereof
CN112142454B (en) * 2020-09-29 2021-08-17 成都贝施美生物科技有限公司 Porcelain powder with self-repairing function
CN114751740B (en) * 2022-04-28 2023-03-28 中国科学院上海硅酸盐研究所 Large-size high-transparency yttrium-stabilized zirconia ceramic and preparation method thereof
ES2982386B2 (en) * 2023-03-15 2025-04-23 Univ Sevilla Alumina activation procedure

Citations (1)

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Publication number Priority date Publication date Assignee Title
US6013591A (en) * 1997-01-16 2000-01-11 Massachusetts Institute Of Technology Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production

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US5032552A (en) 1988-07-04 1991-07-16 Tdk Corporation Biomedical material
US5232878A (en) 1989-06-30 1993-08-03 Hoya Corporation Process for producing inorganic biomaterial

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US6013591A (en) * 1997-01-16 2000-01-11 Massachusetts Institute Of Technology Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production

Non-Patent Citations (5)

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Title
ERIK ADOLFSSON ET AL: "Phase analysis and thermal stability of hot isostatically pressed zirconia-hydroxyapatite composites", vol. 83, no. 11, 1 November 2000 (2000-11-01), pages 2798 - 2802, XP008159032, ISSN: 0002-7820, Retrieved from the Internet <URL:http://www3.interscience.wiley.com/cgi-bin/issn?DESCRIPTOR=PRINTISSN&VALUE=0002-7820> [retrieved on 20041220], DOI: 10.1111/J.1151-2916.2000.TB01634.X *
GAO ET AL.: "Fabrication of HAp-Zr02 (3Y) nano-composite by SPS", BIOMATERIALS, vol. 24, 2003, pages 937 - 940, XP004399586 *
GUO ET AL.: "Laminated and functionally graded hydroxyapatite/yttria stabilized tetragonal zirconia composites fabricated by spark plasma sintering", BIOMATERIALS, vol. 24, 2003, pages 667 - 675, XP004393192 *
MIAO X ET AL: "Spark plasma sintered hydroxyapatite-yttria stabilized zirconia composites", CERAMICS INTERNATIONAL, ELSEVIER, AMSTERDAM, NL, vol. 30, no. 7, 1 January 2004 (2004-01-01), pages 1793 - 1796, XP004534341, ISSN: 0272-8842, DOI: 10.1016/J.CERAMINT.2003.12.117 *
SHUFENG LI ET AL: "Fabrication of hydroxyapatite- incorporated ZrO2-20 wt% Al2O3 by spark plasma sintering and characterization", JOURNAL OF COMPOSITE MATERIALS, SAGE PUBLICATIONS, USA, vol. 43, no. 14, 1 July 2009 (2009-07-01), pages 1503 - 1517, XP008159039, ISSN: 0021-9983, [retrieved on 20090603] *

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GB201111549D0 (en) 2011-08-24
WO2013004361A2 (en) 2013-01-10

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