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WO2013044078A3 - Composites de polymères à teneur élevée en minéraux, élastomères et dégradables - Google Patents

Composites de polymères à teneur élevée en minéraux, élastomères et dégradables Download PDF

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Publication number
WO2013044078A3
WO2013044078A3 PCT/US2012/056641 US2012056641W WO2013044078A3 WO 2013044078 A3 WO2013044078 A3 WO 2013044078A3 US 2012056641 W US2012056641 W US 2012056641W WO 2013044078 A3 WO2013044078 A3 WO 2013044078A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxyapatite
elastomeric
mineral content
polymer composites
degradable high
Prior art date
Application number
PCT/US2012/056641
Other languages
English (en)
Other versions
WO2013044078A2 (fr
Inventor
Jie Song
Artem KUTIKOV
Original Assignee
University Of Massachusetts Medical School
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Massachusetts Medical School filed Critical University Of Massachusetts Medical School
Priority to EP12834037.9A priority Critical patent/EP2768896A4/fr
Priority to CA2849891A priority patent/CA2849891A1/fr
Publication of WO2013044078A2 publication Critical patent/WO2013044078A2/fr
Publication of WO2013044078A3 publication Critical patent/WO2013044078A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/32—Phosphorus-containing compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F1/00—General methods for the manufacture of artificial filaments or the like
    • D01F1/02—Addition of substances to the spinning solution or to the melt
    • D01F1/10—Other agents for modifying properties
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/78—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products
    • D01F6/84—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products from copolyesters
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/78—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products
    • D01F6/86—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products from polyetheresters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/16—Materials with shape-memory or superelastic properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/32—Phosphorus-containing compounds
    • C08K2003/321—Phosphates
    • C08K2003/325—Calcium, strontium or barium phosphate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K2201/00—Specific properties of additives
    • C08K2201/018—Additives for biodegradable polymeric composition

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Textile Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

L'invention propose de nouvelles compositions d'hydroxyapatite et de copolymères à blocs, des procédés de leur préparation et des utilisations de ceux-ci, les copolymères ayant des blocs hydrophobes dégradables et des blocs hydrophiles dégradables pour réaliser une interface stable avec l'hydroxyapatite, conduisant à des suspensions polymère-hydroxyapatite stables. La super-hydrophilicité, l'intégrité mécanique renforcée et l'intégrité structurale conservée du composite HA-PELA dans un environnement aqueux représentent des avantages majeurs par rapport aux composites HA-PLA pour des applications d'ingénierie de tissu squelettique.
PCT/US2012/056641 2011-09-23 2012-09-21 Composites de polymères à teneur élevée en minéraux, élastomères et dégradables WO2013044078A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP12834037.9A EP2768896A4 (fr) 2011-09-23 2012-09-21 Composites de polymères à teneur élevée en minéraux, élastomères et dégradables
CA2849891A CA2849891A1 (fr) 2011-09-23 2012-09-21 Composites de polymeres a teneur elevee en mineraux, elastomeres et degradables

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161538223P 2011-09-23 2011-09-23
US61/538,223 2011-09-23

Publications (2)

Publication Number Publication Date
WO2013044078A2 WO2013044078A2 (fr) 2013-03-28
WO2013044078A3 true WO2013044078A3 (fr) 2015-05-07

Family

ID=47915102

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/056641 WO2013044078A2 (fr) 2011-09-23 2012-09-21 Composites de polymères à teneur élevée en minéraux, élastomères et dégradables

Country Status (3)

Country Link
EP (1) EP2768896A4 (fr)
CA (1) CA2849891A1 (fr)
WO (1) WO2013044078A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2914056A1 (fr) * 2013-05-31 2014-12-24 University Of Massachusetts Medical School Echafaudages composites, mineraux, polymeres, degradables et elastomeres
WO2016181402A1 (fr) 2015-05-14 2016-11-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Traitement de polymères thermodurcis à mémoire de forme pour obtenir des formes 3d complexes
CN108250677B (zh) * 2016-12-29 2022-10-14 中国科学院深圳先进技术研究院 一种包含填料粒子三维网络的聚合物基复合材料及其制备方法
CN109646715A (zh) * 2019-01-25 2019-04-19 上海交通大学医学院附属第九人民医院 电纺3d打印制备含细胞因子微球的多层软骨复合体

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
MOLAMMA P. PRABHAKARAN ET AL.: "Electrospun nanostructured scaffolds for bone tissue engineering.", ACTA BIOMATERIALIA, vol. 5, 2009, pages 2884 - 2893, XP026625141 *
NAOTO SAITO ET AL.: "New synthetic biodegradable polymers as BMP carriers for bone tissue engineering.", BIOMATERIALS, vol. 24, 2003, pages 2287 - 2293, XP004420019 *
See also references of EP2768896A4 *
SEOK-JUNG HONG ET AL.: "Robotic dispensing of composite scaffolds and in vitro responses of bone marrow stromal cells.", J MATER STI: MATER MED, vol. 20, 2009, pages 1955 - 1962, XP019730959 *
TAKASHI KAITO ET AL.: "Potentiation of the activity of bone morphogenetic protein-2 in bone regeneration by a PLA-PEG/hydroxyapatite composite.", BIOMATERIALS, vol. 26, 2005, pages 73 - 79, XP027768340 *

Also Published As

Publication number Publication date
WO2013044078A2 (fr) 2013-03-28
EP2768896A2 (fr) 2014-08-27
EP2768896A4 (fr) 2016-06-22
CA2849891A1 (fr) 2013-03-28

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