+

WO2013043504A1 - Distribution pulsée d'oxygène pour des applications médicales - Google Patents

Distribution pulsée d'oxygène pour des applications médicales Download PDF

Info

Publication number
WO2013043504A1
WO2013043504A1 PCT/US2012/055514 US2012055514W WO2013043504A1 WO 2013043504 A1 WO2013043504 A1 WO 2013043504A1 US 2012055514 W US2012055514 W US 2012055514W WO 2013043504 A1 WO2013043504 A1 WO 2013043504A1
Authority
WO
WIPO (PCT)
Prior art keywords
oxygen
sensor
patient
cannula
fluid delivery
Prior art date
Application number
PCT/US2012/055514
Other languages
English (en)
Inventor
Joel B. METELITS
Original Assignee
Metelits Joel B
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metelits Joel B filed Critical Metelits Joel B
Publication of WO2013043504A1 publication Critical patent/WO2013043504A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/06—Respiratory or anaesthetic masks
    • A61M16/0666—Nasal cannulas or tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes operated by electrical means
    • A61M16/022—Control means therefor
    • A61M16/024—Control means therefor including calculation means, e.g. using a processor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/06—Respiratory or anaesthetic masks
    • A61M16/0666—Nasal cannulas or tubing
    • A61M16/0672—Nasal cannula assemblies for oxygen therapy
    • A61M16/0677—Gas-saving devices therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
    • A61M16/101—Preparation of respiratory gases or vapours with O2 features or with parameter measurement using an oxygen concentrator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0208—Oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3561—Range local, e.g. within room or hospital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
    • A61M2205/3592—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using telemetric means, e.g. radio or optical transmission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards

Definitions

  • the invention relates to devices and methods for effectively and efficiently delivering oxygen to hypoxic patients.
  • LTOT long term oxygen therapy
  • the continuous inhalation of oxygen, typically 2-3 liters per minute (1pm) from a nasal cannula increases the concentration of oxygen that the patient is breathing. It is estimated that for each 1 1pm (liter per minute) of supplemental nasal oxygen flow, the patient can increase their blood oxygen concentration rises by 3-4%. The increase in blood oxygen concentration compensates for the poor function of the patient's lungs in absorbing oxygen.
  • oxygen is prescribed at a fixed flow rate which is based on a 20 minute titration test in the doctor's office, or on an overnight oximetry measurement which indicates more than 5 minutes of less than or equal to 88% saturation or 5 minutes or more or less than 5 min of oxygen saturation less than 90% in certain clinical conditions.
  • the patient's blood oxygen saturation is measured by either using an invasive blood gas analyzer or a non-invasive device such as a pulse oximeter.
  • a blood saturation Sp0 2
  • patients may be sitting or laying down at rest, or be asked to walk about the physician's office, walk on a treadmill, or perform some other strenuous task. They may also be asked to have their blood oxygen content measured during the night while they sleep in their own home (nocturnal oximetry). Based on their testing modalities, if the above stated criteria are met, a fixed flow of oxygen is prescribed. The patient may be advised to increase the flow rate of oxygen during exertion, for example, while climbing stairs, while sleeping or if they feel short of breath. The test which qualified them for oxygen therapy is then repeated while on oxygen therapy to confirm that the problem has been corrected.
  • Patients may be prescribed supplemental oxygen 24 hours per day, during exertion, or just during sleep— depending on their needs. If a patient needs to breathe oxygen even while resting, they often will need a stationary oxygen- generating unit, known as a concentrating unit, which can be set up to produce up to 10 1pm depending on patients' needs. If patients require oxygen while ambulating, they typically will carry small high-pressure oxygen cylinders or small refillable liquid oxygen dewars. Small portable oxygen generators also have been introduced into the market, but they are often unable to deliver more than 3-4 1pm. They must have a power supply (battery or plug in to AC current) and carry the drawbacks of more weight than portable cylinders, and shorter battery life.
  • a power supply battery or plug in to AC current
  • LTOT long term oxygen therapy
  • conserving oxygen devices In addition to frequently failing at their mission, conserving oxygen devices often give the patient and medical providers a false sense of security. Patients who travel with oxygen conservation devices are particularly vulnerable to issues of increased costs, battery capacity, and at times reliance on less than ideal pulse triggering technology. A large nostriled individual will not trigger a standard conserving regulator without some training—which eliminates functional use during sleep when training has no impact. A person walking across a parking lot may need to stop walking and focus on nasal breathing to trigger most currently available devises.
  • the present invention provides an oxygen delivery system comprising a dual sensing device separately triggered through the mouth and through the nose of a patient, to whichever orifice is “requesting” the oxygen thereby efficiently delivering the oxygen where the inflow of air can most effectively get to the lung alveoli and efficiently supplement the patent's needed oxygenation.
  • an oxygen mask with continuous flow could do the same thing, but with much more “discomfort” and with a lot of wasted supplemental oxygen as there are no available conserving mask triggered oxygenators.
  • an apparatus separately sensing nasal air flow and oral air flow-each sensor connected to a conservation oxygen regulator regular which will efficiently deliver a supplemental pulse of oxygen through the pathway that initiated the air flow and hence triggered the sensor.
  • oral and nasal pathways use separated solenoid oxygen conserving regulators and in another embodiment the oral and nasal pathways share one oxygen conserving regulator.
  • the oxygen conserver controller includes a pressure valve assembly adapted to open upon detection of pressure reduction on patient inhalation, and close until the patient takes another breath.
  • the system includes an electronic remote sensor and trigger mechanism for controlling the oxygen conserver controller.
  • FIG. 1 is a block diagram of a system for fluid delivery in accordance with a first embodiment of the present invention
  • FIGs. 2 A and 2B are schematics each illustrating actuation of a pressure valve assembly in accordance with the first embodiment of the present invention
  • FIG. 3 A - 3C are schematics illustrating a Diaphragm Effect in accordance with the first embodiment of the present invention.
  • FIGs. 4 - 6 are schematics of various embodiments of oronasal cannulae in accordance with the first embodiment of the present invention
  • FIGs. 7A - 7C are a series of graphs illustrating airflow in a patient in accordance with the present invention.
  • FIG. 7D is a graph illustrating oxygen flow from a fluid delivery system in accordance with the present invention.
  • FIG. 8 A is a graph illustrating a tidal volume of a patient with COPD
  • FIG. 8B is a graph illustrating time/volume oxygen delivery to a patient in accordance with the present invention.
  • FIG. 9A is a schematic of the second embodiment of the present invention
  • FIG. 9B is an enlarged perspective view of a nasal flow sensor element of the Fig. 9 embodiment
  • FIG. 9C is an enlarged perspective view of an oral flow sensor element of the Fig. 9 embodiment.
  • FIG. 9D is an exploded view of a valve assembly in accordance with a second embodiment of the present invention.
  • FIG. 10 is a block diagram of a trigger mechanism in accordance with the second embodiment of the present invention.
  • FIG. 11 is a block diagram of a remote sensor in accordance with the second embodiment of the present invention.
  • FIG. 12 is a graph illustrating oxygen flow from a fluid delivery system in accordance with a second embodiment of the present invention.
  • the fluid delivery system of the present invention provides oxygen, to a patient in intermittent, periodic, or pulsated time intervals.
  • the fluid delivery system includes a pressure valve assembly that opens as a result of change in pressure caused by a patient's inhalation, and closes after inhalation. Consequently, the flow of supplementary oxygen is turned on and off in response to the patient's respiratory cycle. As a result, supplementary oxygen is conserved because the supplementary oxygen is not provided when the patient is not breathing in.
  • Inhalation is the movement of air from the external environment, through the airways, and into the lungs.
  • the chest expands and the diaphragm contracts downwardly or caudally, resulting in expansion of the intrapleural space and a negative pressure within the chest cavity.
  • This negative pressure results in airflow from either the nose or the mouth into the pharynx (throat) and trachea, eventually entering the lungs.
  • the fluid delivery system 100 of the present invention comprises a fluid source 102 and a fluid regulator 104 coupled to the fluid source 102.
  • fluid sources 102 include: an oxygen generation apparatus, a stationary oxygen reservoir within a hospital setting, or a portable canister of pressurized oxygen, a liquid oxygen dewar, or a pressurized oxygen reservoir.
  • the fluid delivery system 100 further includes a power source 1 12, such as a battery or utility power.
  • the fluid regulator 104 discontinues oxygen flow at a predetermined pressure at the outlet end 108.
  • the fluid regulator 104 includes a dual pressure gauge that measures inlet pressure at the source 102 (e.g., oxygen left in the fluid source 102), and outlet pressure at the outlet end 108.
  • the fluid regulator 104 triggers a pressure valve assembly open at patient inhalation and/or triggers the pressure valve assembly closed at patient exhalation.
  • inhalation is used
  • FIG. 2 A illustrates a pressure valve assembly 120 in an open configuration wherein oxygen from source 102 is provided to patient 106 via an oronasal cannula shown generally at 130
  • FIG. 2B illustrates a pressure valve assembly 120 in a closed configuration wherein oxygen from source 102 is not provided to patient 106.
  • Fluid regulator 104 detects this pressure reduction at outlet end 108 and triggers pressure valve assembly 120 to the open configuration of FIG. 2 A.
  • the pressure in the cannula increases. Fluid regulator 104 detects this pressure increase at outlet end 108 and triggers pressure valve assembly 120 to the closed configuration of FIG. 2B.
  • the negative pressure upon inhalation may be caused, in part, by the Bernouli Effect.
  • the streamline of air e.g., from either the nose or the mouth
  • a drop in pressure occurs due to the increased velocity of the passage of air across the rim of the proximal end of the cannula.
  • This drop in pressure triggers the pressure valve assembly 120 to open.
  • the opening of the proximal end is configured to be substantially orthogonal to the streamline of air during respiration.
  • the negative pressure upon inhalation may be caused, in part, by the Diaphragm Effect.
  • the active process of breathing requires the contraction of skeletal muscles within the chest cavity, including the external intercoastal muscles (located between the ribs) and the diaphragm (a flat muscle located between the thoracic & abdominal cavities).
  • Fluid regulator 104 detects this pressure increase at outlet end 108 and triggers pressure valve assembly 120 to the closed
  • FIG. 3 A represents the diaphragm at rest during the end of passive exhalation.
  • the intrapleural pressure is illustrated to be about -5mm Hg. Because the alveolar pressure is zero and the atmospheric pressure is zero, there is no gradient between the nasopharynx and the lungs. Therefore, there is no net movement of air.
  • FIG. 3B represents diaphragmatic contraction during inspiration. The intrapleural pressure is more negative (e.g., -7 mm Hg verus -5mm llg) and the alveolar pressure is about - 5 mm llg, for example. Because the atmospheric pressure is zero, a pressure gradient exists such that there is a net movement of air into the lungs.
  • FIG. 3C represents diaphragmatic relaxation during exhalation. Both the intrapleural pressure and the alveolar pressure are positive. Because the atmospheric pressure is zero, a pressure gradient exists such that there is a net movement of air out of the lungs.
  • FIGs. 4 - 6 illustrate a plurality of embodiments of oronasal cannula 130.
  • FIG. 4A shows a front elevation view of nose 222 and mouth 518 of patient 106 in the XY plane of a Cartesian coordinate system 526.
  • FIG. 4B is a right side elevation view of same.
  • An oronasal cannula 500 has three sections: a nasal section 502; a tubing section 504; and an oral section 506.
  • the nasal section 502 includes at least one nasal cannula, here depicted as nasal cannulae 512 and 514.
  • the tubing section 504 includes tubing of the cannula supplies oxygen from source 102 via the fluid regulator 104.
  • the mouth section 506 includes at least one oral cannula 508 that extends proximal to the mouth 51 8 of the patient.
  • the length of each of the nasal cannula 502 and the oral cannula section 506 is adjustable so that it can accommodate the anatomy of the patient.
  • the oral cannula 508 has detachable components that fit together via a connection section 510.
  • Connection section 510 preferably comprises an adjustable length sleeve.
  • the oronasal cannula of the present invention can comprise a connection section of 510 of fixed length, in which case a plurality of oronasal cannulae of different lengths may be supplied.
  • Other forms of extendable or detachable tubing for the oral and/or nasal cannulae are also contemplated.
  • the proximal ends of the nasal cannulae 512 and 514 are formed to include openings 513 and 515, respectively. Those skilled in the art will appreciate, that air moves into, and out of, nose 222 along the Z axis.
  • openings 513 and 515 are disposed within the X/Y plane. In such case, in certain embodiments, air moving into, and out of nose 222 passes across openings 513 and 51 5. In these embodiments, the rim of opening 513 and the rim of opening 515 are each substantially orthogonal to the flow of air during nasal respiration. In certain embodiments, proximal ends of the nasal cannulae 512 and 514 extend into the patient's nostrils. In these embodiments, proximal ends of the nasal cannulae 512 and 514 are coaxial with the flow of air during nasal respiration.
  • the plane of the rim of the openings 513 and 515 are rotated at an angle in the -Z direction within the coordinate system 526.
  • movement of air into the nose during inspiration will cause induce a negative pressure in cannula 130.
  • movement of air outwardly from the nose during exhalation will primarily push against the back of the nasal cannula 512 and 514, and will not induce a negative pressure in cannula 130. Consequently, the orientation of nasal cannula 514 promotes triggering of the pressure valve assembly to open during inhalation while not triggering the pressure valve assembly to open during exhalation.
  • the proximal end of the oral cannula 508 has an opening 516 formed therein.
  • the plane of the opening at the proximal end of the oral cannula 508 is non-parallel to the movement of air 514 of air during oral respiration.
  • orientations of the opening of the proximal end of the nasal and/or oral cannulae relative to the streamlines 228 and 524, respectively, are also contemplated.
  • the orientation of the opening of the proximal end of the nasal and/or oral cannula relative to the respective streamline is selected from the group consisting of: rotating the plane of the rim between 0-90 degrees about one or more of the X-axis, Y-axis, and Z-axis of the coordinate system 526.
  • FIGs. 5 and 6 each depict other embodiments of oronasal cannulae in accordance with the present invention.
  • the oronasal cannula includes two nasal cannulae 602 and 604 that each are oriented toward the center of the nose and two oral cannulae 606 and 608 that are each oriented toward the center of the mouth.
  • FIG. 5 also depicts a mouth guard 610 that caps the mouth to reduces release of supplementary oxygen into the ambient environment.
  • FIG. 6 depicts an oronasal cannula with two nasal cannulae each with openings that face directly into the patient's streamline of air and two oral cannulae 704 and 706 that each have a bent orientation.
  • supplementary oxygen is delivered during predetermined phases within the respiratory cycle.
  • FIGs. 7A-7D graphs depict the inspiration phase 802 and the expiration phase 804 of the respiratory cycle.
  • FIG. 7A illustrates intra-alveolar pressure
  • FIG. 7B illustrates intrapleural pressure
  • FIG. 7C illustrates the volume of air movement during the respiratory cycle.
  • FIG. 7D illustrates the amount of supplementary oxygen delivered 806 by conventional means.
  • conventional means 806 delivers supplementary oxygen in a continuous fashion, independent of the phases of the respiratory cycle.
  • supplementary oxygen is delivered in an intermittent or pulsated fashion when using the fluid delivery system 100 of FIG. 1.
  • supplementary oxygen is delivered during the inspiration phase 802 of the respiratory cycle but not delivered during the expiration phase 804 of the respiratory cycle.
  • the supplementary oxygen is delivered during predetermined sub-phases within the respiratory cycle that will provide the most amount of gas exchange.
  • Tidal volume is the volume of air displaced during respiration, which is about 500 ml or 7 ml/kg bodyweight. Only a portion, however, of the tidal volume is involved in gas exchange in the lungs.
  • Dead space is air that is inhaled but not involved in alveoli gas exchange.
  • Anatomical dead space is the gas that is inhaled that does not come into contact with the alveloli, such as the air that remains in the trachea.
  • Alveolar dead space is gas that is in the alveoli that does not interact with blood flow in adjacent pulmonary capillaries.
  • the first gas to arrive at the alveoli is the 1 0 mL of oxygen poor gas already occupying the dead space in the airways. This is followed by the first 300 mL of inspired gas. The final 150 mL of inspired gas will fill the dead space at the end of inspiration but not reach the alveoli. Ideally, oxygen is delivered prior to this last 150 mL of inspiration.
  • a graph 900 depicts tidal volume of a patient with COPD.
  • the fluid regulator 104 can be constructed to trigger open the pressure valve assembly at time 0 seconds, element 906 of FIG. 8 A, and to trigger shut the pressure valve assembly at time 0.5 seconds, element 908, for example.
  • a volume of supplementary oxygen is delivered (area under curve 910-FIG. 8b) to the patient during the initial sub-phase of inspiration.
  • Other pulsed oxygen delivery during sub- phases within the respiratory cycle are also contemplated.
  • the oxygen conserver controller 1000 is triggered on and off by a remote sensor 1002 and trigger mechanism 1004.
  • remote sensor 1002 which may be formed integrally with the oronasal cannula, or located upstream thereof, senses the onset of patient inhalation, and transmits the information to a remote trigger mechanism which in turn turns the conserving regulator 1000 on and off. Any sensor or combination of sensors that can be used to measure or identify the difference in properties between and inhalation and exhalation maneuver that can be used to synchronize and turn the conserving regulator on and off.
  • Other sensors such as acoustic sensors that detect the sound of inhalation and exhalation flow such as described in U.S. Published Application No. 2005/0183725 or in U.S. Patent No. 6,152,130 advantageously may be employed.
  • Yet another possible sensor comprises an electro -mechanical sensor having a moveable vane capable of being displaced when air flow is generated by patient inhalation, for example, following the teachings of U.S. Patent 5,655,523.
  • the remote sensor and trigger mechanism may be hard wired, e.g. by incorporating wires into the tubing, connecting the sensor and trigger mechanism and the oxygen supply, but preferably is designed to communicate wirelessly, for example, using Bluetooth short-wave length radio transmission technology.
  • the oronasal canula is a modification of Fig. 5 where the size is modified to be less obtrusive but still demonstrates the essential feature of separate channels for access, trigger, and delivery to the nasal passages and or the oral passage way.
  • the separate nasal 1002 and oral 1004 passages in Fig. 9 A have separate nasal and oral flow measurement sensor 1006, 1008, respectively which communicate with trigger amplification mechanism 1010 which will "amplify" the weakest impulse of breath either through the nose or mouth, and retrofit the currently available conserving regulators or ultimately be included in future conserving regulators.
  • a main criteria for the sensor is to sense even the weakest of respiratory efforts and rapidly ⁇ well within the current standard of 0.5 second of inspiration trigger the release of pulsed oxygen. Since the currently available sensors for conserving units can, in ideal circumstances provide a six to one efficiency ratio, the improved ability to sense oral inspiration can make this dual sensing mechanism available to mouth breathers when sleeping and mouth breathing when walking and unable to oxygenate adequately with the current conserving units. This dual passage effectiveness of oxygen treatment may improve enough to allow hypoxic patients currently limited by 3 liters per min when sleeping to avoid hypoxia with currently available ambulatory oxygen treatment and currently available nocturnal oxygenators small enough for travel.
  • Reference numbers 1006 and 1008 represent sensors designed to measure infinitesimal flow in the nose 1006 (one path) and the mouth 1008 (a second path) and through microprocessors (1012), both battery powered (1016), which will communicate with the trigger mechanism (1004)
  • a Bluetooth communicator which would turn on an LED when the battery weakens enough to risk failure to sense efforts of breathing or delivery of oxygen.
  • the remote sensor system includes sensors 1006 and 1008 as described above communicating with a microprocessor 1012.
  • An LED 1014 preferably is included to signal that the sensor is on and that the battery 1016 has sufficient charge.
  • the microprocessor 1012 receives signals from sensor 1010, and transmits the signals via a Bluetooth transmitter 1018 to trigger mechanism 1020.
  • the trigger mechanism 1020 includes a Bluetooth receiver 1022 which communicates with microprocessor 1024 for sending signals to a solenoid valve mechanism 1026.
  • Trigger mechanism 1020 includes a battery 1028 and an LED 1030 for signaling when the trigger mechanism is activated and that the battery has sufficient charge.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La présente invention concerne un système de distribution de fluide qui fournit un fluide, tel que de l'oxygène supplémentaire, à un patient à des intervalles de temps périodiques. Le système de distribution de fluide comprend un ensemble valve de pression qui s'ouvre en réponse à un changement de débit provoqué par une inhalation du patient et qui se ferme après l'inhalation.
PCT/US2012/055514 2011-09-20 2012-09-14 Distribution pulsée d'oxygène pour des applications médicales WO2013043504A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161536973P 2011-09-20 2011-09-20
US61/536,973 2011-09-20

Publications (1)

Publication Number Publication Date
WO2013043504A1 true WO2013043504A1 (fr) 2013-03-28

Family

ID=47914777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/055514 WO2013043504A1 (fr) 2011-09-20 2012-09-14 Distribution pulsée d'oxygène pour des applications médicales

Country Status (1)

Country Link
WO (1) WO2013043504A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015034942A1 (fr) * 2013-09-04 2015-03-12 Metelits Joel B Distribution d'oxygène pulsée déclenchée par un écoulement pour applications médicales
CN111065430A (zh) * 2017-08-22 2020-04-24 皇家飞利浦有限公司 呼吸面罩及面罩控制方法
US11247008B1 (en) 2020-08-05 2022-02-15 Effortless Oxygen, Llc Flow triggered gas delivery
US11318276B2 (en) 2020-08-05 2022-05-03 Effortless Oxygen, Llc Flow triggered gas delivery
US11420007B2 (en) 2020-08-05 2022-08-23 Effortless Oxygen, Llc Flow triggered gas delivery

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5694923A (en) * 1996-08-30 1997-12-09 Respironics, Inc. Pressure control in a blower-based ventilator
US20040035422A1 (en) * 1999-07-02 2004-02-26 Respironics, Inc. Pressure support system and method and a pressure control valve for use in such a system and method
US20050033247A1 (en) * 2003-08-06 2005-02-10 Thompson Paul S. Nasal cannula assembly
US20070215156A1 (en) * 2004-04-15 2007-09-20 Resmed Limited Snoring Treatment Apparatus and Methods of Managing Snorers
US20080236584A1 (en) * 2005-04-01 2008-10-02 Ric Investments, Llc Gas Conserving Device

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5694923A (en) * 1996-08-30 1997-12-09 Respironics, Inc. Pressure control in a blower-based ventilator
US20040035422A1 (en) * 1999-07-02 2004-02-26 Respironics, Inc. Pressure support system and method and a pressure control valve for use in such a system and method
US20050033247A1 (en) * 2003-08-06 2005-02-10 Thompson Paul S. Nasal cannula assembly
US20070215156A1 (en) * 2004-04-15 2007-09-20 Resmed Limited Snoring Treatment Apparatus and Methods of Managing Snorers
US20080236584A1 (en) * 2005-04-01 2008-10-02 Ric Investments, Llc Gas Conserving Device

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014315301B2 (en) * 2013-09-04 2017-09-28 Joel B. Metelits Flow triggered pulsed oxygen delivery for medical applications
CN111467618A (zh) * 2013-09-04 2020-07-31 轻松氧气有限责任公司 用于医学应用的流体触发脉冲氧气输送
EP3041587A1 (fr) * 2013-09-04 2016-07-13 Joel B. Metelits Distribution d'oxygène pulsée déclenchée par un écoulement pour applications médicales
JP2016536081A (ja) * 2013-09-04 2016-11-24 メテリッツ，ジョエル，ビー． 医療用途のための流れで起動するパルス化された酸素供給
EP3041587A4 (fr) * 2013-09-04 2017-05-10 Joel B. Metelits Distribution d'oxygène pulsée déclenchée par un écoulement pour applications médicales
US9707366B2 (en) 2013-09-04 2017-07-18 Joel B. Metelits Flow triggered pulsed oxygen delivery for medical applications
CN105579102A (zh) * 2013-09-04 2016-05-11 乔尔·B·梅特丽茨 用于医学应用的流体触发脉冲氧气输送
RU2668067C9 (ru) * 2013-09-04 2019-06-14 Джоэл Б. МЕТЕЛИЦ Доставка кислорода, инициируемая потоком в импульсном режиме, для медицинских применений
WO2015034942A1 (fr) * 2013-09-04 2015-03-12 Metelits Joel B Distribution d'oxygène pulsée déclenchée par un écoulement pour applications médicales
RU2668067C2 (ru) * 2013-09-04 2018-09-25 Джоэл Б. МЕТЕЛИЦ Доставка кислорода, инициируемая потоком в импульсном режиме, для медицинских устройств
CN111065430A (zh) * 2017-08-22 2020-04-24 皇家飞利浦有限公司 呼吸面罩及面罩控制方法
CN111065430B (zh) * 2017-08-22 2023-03-07 皇家飞利浦有限公司 呼吸面罩及面罩控制方法
US11247008B1 (en) 2020-08-05 2022-02-15 Effortless Oxygen, Llc Flow triggered gas delivery
US11318276B2 (en) 2020-08-05 2022-05-03 Effortless Oxygen, Llc Flow triggered gas delivery
US11420007B2 (en) 2020-08-05 2022-08-23 Effortless Oxygen, Llc Flow triggered gas delivery

Similar Documents

Publication Publication Date Title
CN102762250B (zh) 用于包括具有夹带端口和/或压力特征的非密封通气界面的无创通气的方法、系统和装置
US9707366B2 (en) Flow triggered pulsed oxygen delivery for medical applications
JP5891226B2 (ja) Ｌｏｘを使用して換気補助を提供する方法、システム及び装置
US9295795B2 (en) System for providing flow-targeted ventilation synchronized to a patients breathing cycle
US10926051B2 (en) Respiratory interface
EP2414019A1 (fr) Procédés, systèmes et dispositifs de ventilation ouverte non invasive à l'aide d'ajutages de fourniture de gaz à l'air libre
WO2013043504A1 (fr) Distribution pulsée d'oxygène pour des applications médicales
JP2024116302A (ja) 流れで起動するガス供給
US11247008B1 (en) Flow triggered gas delivery
US20220040444A1 (en) Flow Triggered Gas Delivery
US12251515B2 (en) Respiratory interface
US20220040426A1 (en) Flow Triggered Gas Delivery

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12833152

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12833152

Country of ref document: EP

Kind code of ref document: A1

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载