WO2012138368A1 - Dispositifs, compositions et procédés utilisant des agonistes de récepteur ep4 et ep2 pour prévenir, réduire ou traiter une contracture capsulaire - Google Patents
Dispositifs, compositions et procédés utilisant des agonistes de récepteur ep4 et ep2 pour prévenir, réduire ou traiter une contracture capsulaire Download PDFInfo
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- WO2012138368A1 WO2012138368A1 PCT/US2011/045855 US2011045855W WO2012138368A1 WO 2012138368 A1 WO2012138368 A1 WO 2012138368A1 US 2011045855 W US2011045855 W US 2011045855W WO 2012138368 A1 WO2012138368 A1 WO 2012138368A1
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- receptor agonists
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- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 210000000062 pectoralis major Anatomy 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 238000000751 protein extraction Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000004759 spandex Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000003153 stable transfection Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/432—Inhibitors, antagonists
- A61L2300/436—Inhibitors, antagonists of receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/04—Materials or treatment for tissue regeneration for mammary reconstruction
Definitions
- the present invention relates to pharmaceutical compositions for preventing, reducing, or treating capsular contracture, the composition comprising a therapeutically effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof, Compound I or a pharmaceutically acceptable salt thereof, Compound II or a pharmaceutically acceptable salt thereof, or a combination thereof.
- the compound(s) may be present alone or in combination with one or more pharmaceutically acceptable excipients.
- Compound I treatment significantly reduced the width in the middle and bottom parts of scars, but displayed only a tendency to decrease scar width at the superficial region ( Figures 5 and 6 A and B). Grossly, Compound I treated animals had smaller and softer skin scar, and significantly slimmer appearances than vehicle-treated animals ( Figures 5 and 6 A and B).
- the structure effective to release the composition may be in the form of a mechanism, such as one or more osmotic pumps known in the medical device art and discussed in greater detail hereinafter.
- Other suitable structures effective to release a composition include coatings on the envelope, or any other suitable mechanism known in the art which will be capable of releasing the desired composition into the patient in conjunction with the implantation of the prosthesis.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des dispositifs, des compositions et des procédés utilisant des agonistes de récepteur EP4 et EP2 pour prévenir, réduire, ou traiter une contracture capsulaire survenant en réponse à l'implantation de prothèses mammaires.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11746361.2A EP2694120A1 (fr) | 2011-04-07 | 2011-07-29 | Dispositifs, compositions et procédés utilisant des agonistes de récepteur ep4 et ep2 pour prévenir, réduire ou traiter une contracture capsulaire |
| CA2832589A CA2832589A1 (fr) | 2011-04-07 | 2011-07-29 | Dispositifs, compositions et procedes utilisant des agonistes de recepteur ep4 et ep2 pour prevenir, reduire ou traiter une contracture capsulaire |
| AU2011364973A AU2011364973A1 (en) | 2011-04-07 | 2011-07-29 | Devices, compositions and methods utilizing EP4 and EP2 receptor agonists for preventing, reducing or treating capsular contracture |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161472878P | 2011-04-07 | 2011-04-07 | |
| US61/472,878 | 2011-04-07 | ||
| US201161474195P | 2011-04-11 | 2011-04-11 | |
| US61/474,195 | 2011-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2012138368A1 true WO2012138368A1 (fr) | 2012-10-11 |
Family
ID=46966706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2011/045855 WO2012138368A1 (fr) | 2011-04-07 | 2011-07-29 | Dispositifs, compositions et procédés utilisant des agonistes de récepteur ep4 et ep2 pour prévenir, réduire ou traiter une contracture capsulaire |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20120259413A1 (fr) |
| EP (1) | EP2694120A1 (fr) |
| AU (1) | AU2011364973A1 (fr) |
| CA (1) | CA2832589A1 (fr) |
| WO (1) | WO2012138368A1 (fr) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728396A (en) | 1996-02-02 | 1998-03-17 | Alza Corporation | Sustained delivery of leuprolide using an implantable system |
| US20020183722A1 (en) | 2001-04-19 | 2002-12-05 | Harper Derek J. | Implantable osmotic pump |
| US20030069205A1 (en) * | 1991-05-31 | 2003-04-10 | Gliatech Inc. | Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers |
| US20040235958A1 (en) | 2003-02-11 | 2004-11-25 | Allergan, Inc. | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| US20050164992A1 (en) | 2003-02-11 | 2005-07-28 | Allergan, Inc. | Treatment of inflammatory bowel disease |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITVR20010098A1 (it) * | 2001-09-11 | 2003-03-11 | Consorzio Per Gli Studi Uni | Procedimento per l'ottenimento di idrogeli di fibroina di seta. |
| EP1687041A2 (fr) * | 2003-11-20 | 2006-08-09 | Angiotech International AG | Implants pour tissus mous et agents anti-cicatrices |
| CA2585367A1 (fr) * | 2004-10-26 | 2006-05-04 | Allergan, Inc. | Methodes therapeutiques et d'administration d'agonistes de prostaglandine ep4 |
-
2011
- 2011-07-29 CA CA2832589A patent/CA2832589A1/fr not_active Abandoned
- 2011-07-29 EP EP11746361.2A patent/EP2694120A1/fr not_active Withdrawn
- 2011-07-29 WO PCT/US2011/045855 patent/WO2012138368A1/fr active Application Filing
- 2011-07-29 AU AU2011364973A patent/AU2011364973A1/en not_active Abandoned
- 2011-07-29 US US13/193,774 patent/US20120259413A1/en not_active Abandoned
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030069205A1 (en) * | 1991-05-31 | 2003-04-10 | Gliatech Inc. | Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers |
| US5728396A (en) | 1996-02-02 | 1998-03-17 | Alza Corporation | Sustained delivery of leuprolide using an implantable system |
| US20020183722A1 (en) | 2001-04-19 | 2002-12-05 | Harper Derek J. | Implantable osmotic pump |
| US20040235958A1 (en) | 2003-02-11 | 2004-11-25 | Allergan, Inc. | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| US6875787B2 (en) | 2003-02-11 | 2005-04-05 | Allergan, Inc. | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| US20050164992A1 (en) | 2003-02-11 | 2005-07-28 | Allergan, Inc. | Treatment of inflammatory bowel disease |
Non-Patent Citations (6)
| Title |
|---|
| HAMMOND, D.C.: "The Periareolar Approach to Breast Augmentation", CLIN PLASTIC SURG, vol. 36, 2009, pages 45 - 48 |
| HAYASHI K ET AL: "Effect of a prostaglandin EP4 receptor agonist on early fixation of hydroxyapatite/titanium composite- and titanium-coated rough-surfaced implants in ovariectomized rats", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH - PART A 20100301 JOHN WILEY AND SONS INC. USA LNKD- DOI:10.1002/JBM.A.32444, vol. 92, no. 3, 1 March 2010 (2010-03-01), pages 1202 - 1209, XP002663697, ISSN: 1549-3296 * |
| KOTHAPALLI, D., HAYASHI, N., GROTENDORST, G.R.: "Inhibition of TGF-beta-stimulated CTGF gene expression and anchorage-independent growth by CAMP identifies a CTGF-dependent restriction point in the cell cycle", FASEB J., vol. 12, no. 12, 1998, pages 1151 - 61, XP002354274 |
| MOREIRA, M. ET AL.: "The effect of liposome-delivered prednisolone on collagen density, myofibroblasts, and fibrous capsulae thickness around silicone breast implants in rats", WOUND REPAIR REGEN., vol. 18, no. 4, 2010, pages 417 |
| STRATTON RICHARD ET AL: "Role of prostaglandins in fibroblast activation and fibrosis.", JOURNAL OF CELL COMMUNICATION AND SIGNALING JUN 2010 LNKD- PUBMED:20531982, vol. 4, no. 2, June 2010 (2010-06-01), pages 75 - 77, XP002663698, ISSN: 1873-961X * |
| TAN, K.T. ET AL.: "Tumor necrosis factor-a expression is associated with increased severity of periprosthetic breast capsular contracture", EUR SURG RES., vol. 45, no. 3-4, 2010, pages 327 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011364973A1 (en) | 2013-11-07 |
| US20120259413A1 (en) | 2012-10-11 |
| EP2694120A1 (fr) | 2014-02-12 |
| CA2832589A1 (fr) | 2012-10-11 |
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